Yoshida Kiyotsugu 吉田清嗣

… Alternative Names

YOSHIDA Kiyotsugu 吉田清嗣

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Researcher Number	70345312
External Links
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2024: 東京慈恵会医科大学, 医学部, 教授 2007 – 2011: Tokyo Medical and Dental University, 難治疾患研究所, 准教授 2005 – 2006: 東京医科歯科大学, 難治疾患研究所, 助教授 2003 – 2004: 東京医科歯科大学, 難治疾患研究所, 助手
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Biological Sciences / Medium-sized Section 50:Oncology and related fields / Tumor biology / Basic Section 50010:Tumor biology-related / Tumor diagnostics / Tumor diagnosis / Tumor biology / Biological Sciences / Functional biochemistry … More Except Principal Investigator … More Basic Section 53010:Gastroenterology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 55020:Digestive surgery-related / Pathological medical chemistry / Gastroenterology Less
Keywords	Principal Investigator プロテオミクス / 癌 / アポトーシス / DNA損傷 / がん細胞 / キナーゼ / リン酸化 / 幹細胞 / ストレス / 腫瘍マーカー … More / プロテオーム / リン酸化酵素 / 細胞周期 / Lyn / PKCδ / c-Abl / 細胞外小胞分泌 / 一次繊毛 / 非対称分裂 / 癌幹細胞 / 細胞分裂 / がん幹細胞 / 転移 / 上皮間葉転換 / プロテーム / 質量分析 / 分子標的 / ユビキチン化 / DNA傷害 / がん治療 / レドックス制御 / 酸化ストレス / リナーゼ … More Except Principal Investigator 肝癌 / 大腸癌 / 転移 / 癌幹細胞 / がん幹細胞 / リンパ節転移 / DYRK2 / 遠隔転移 / PKCδ / 幹細胞 / 型破り分泌蛋白質 / バイオマーカー / 型破り分泌蛋白 / 早期診断 / 分化 / 脂質 / リン酸化酵素 / 脂質代謝 / 癌 / 肝発生 / 肝幹細胞 Less

Functional analysis of PKC delta in distant metastasis of colorectal cancer
- Principal Investigator
  
  大熊誠尚
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jikei University School of Medicine
一次繊毛と細胞外小胞分泌を特性とするがん幹細胞の新規概念創出とその生物学的意義Principal Investigator
- Principal Investigator
  
  吉田清嗣
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Jikei University School of Medicine
リン酸化酵素DYRK2を介する大腸癌リンパ節転移の機序解明と革新的治療法開発
- Principal Investigator
  
  衛藤謙
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Jikei University School of Medicine
肝癌特異的な細胞外分泌蛋白を用いた新規早期診断法確立とその実用化に向けた検証研究
- Principal Investigator
  
  及川恒一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Jikei University School of Medicine
Elucidation for molecular mechanism of carcinogenesis driven by cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  Yoshida Kiyotsugu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Jikei University School of Medicine
Gene therapy development in liver cancer
- Principal Investigator
  
  Oikawa Tsunekazu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Jikei University School of Medicine
Elucidation for molecular mechanism of cancer stem cells by the live-imaging technologyPrincipal Investigator
- Principal Investigator
  
  Yoshida Kiyotsugu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Jikei University School of Medicine
Molecular mechanism of tumor progression by the regulation of glucose and lipid metabolism
- Principal Investigator
  
  Yogosawa Satomi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Jikei University School of Medicine
Molecular mechanism of tumor metastasis driven by cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  Yoshida Kiyotsugu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Jikei University School of Medicine
The role of DYRK2 in primary liver cancers
- Principal Investigator
  
  Oikawa Tsunekazu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine
Molecular mechanisms of cancer stem cells for neoplastic cellular transformationPrincipal Investigator
- Principal Investigator
  
  YOSHIDA KIYOTSUGU
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Jikei University School of Medicine
Comprehensive identification of tumor-targeting molecules based on the quantitative proteome analysisPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Kiyotsugu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor diagnostics
- Research Institution
  Jikei University School of Medicine
プライミングリン酸化反応の制御機構とその破綻による病態解明Principal Investigator
- Principal Investigator
  
  吉田清嗣
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Jikei University School of Medicine
  Tokyo Medical and Dental University
Elucidation for molecular mechanisms of neoplastic cell transformationPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Kiyotsugu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Jikei University School of Medicine
  Tokyo Medical and Dental University
Comprehensive identification of novel tumor markers by targeted shotgun proteomicsPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Kiyotsugu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor diagnosis
- Research Institution
  Jikei University School of Medicine
  Tokyo Medical and Dental University
がん抑制遺伝子p53による細胞死誘導機構の解明とがん治療への応用Principal Investigator
- Principal Investigator
  
  吉田清嗣
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Elucidation for crosstalk of the nuclear-cytoplasic signalling in the apoptotic response to oxidative stressPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Kiyotsugu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical and Dental University
バイオイメージングによるアダプター結合阻害を標的としたアポトーシス誘導分子の探索Principal Investigator
- Principal Investigator
  
  吉田清嗣
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Medical and Dental University
ストレス応答性アポトーシス制御因子の網羅的探索と機能解析Principal Investigator
- Principal Investigator
  
  吉田清嗣
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical and Dental University
DNA損傷誘発性がん細胞死の抑制因子探索とその制御機構Principal Investigator
- Principal Investigator
  
  吉田清嗣
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
機能プロテオミクス解析によるDNA損傷誘発性がん細胞死の制御機構の解明Principal Investigator
- Principal Investigator
  
  吉田清嗣
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
DNA損傷におけるがん細胞のアポトーシス誘導制御と機能解析Principal Investigator
- Principal Investigator
  
  吉田清嗣
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical and Dental University

[Book] Functional role for the c-Abl tyrosine kinase signalling in the DNA damage response. In: Kimura S and Shimizu S (eds), DNA repair: New Research.2012
- Author(s)
  Yoshida K.
- Publisher
  Nova Science Publishers, Inc
- Data Source
  KAKENHI-PROJECT-23650612
[Book] Functional role for the c-Abl tyrosine kinase signalling in the DNA damage response. In : Kimura S and Shimizu S (eds), DNA repair : New Research2012
- Author(s)
  Yoshida K
- Publisher
  Nova Science Publishers, Inc
- Data Source
  KAKENHI-PROJECT-23300347
[Book] Tumor Suppressors.(Molecular function of the p53 tumor suppressor in the apoptotic response to DNA damage.)(Nguyen SD (ed))2011
- Author(s)
  Yoshida K.
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-20390091
[Book] Molecular function of the p53 tumor suppressor in the apoptotic response to DNA damage. in Chapter 12 of Tumor Suppressors.2011
- Author(s)
  Yoshida K
- Publisher
  Nova Science Publishers, Inc
- Data Source
  KAKENHI-PROJECT-23650612
[Book] Role for PKCδ on apoptosis in the DNA damage response. In : Clark C. Chen (ed), Selected T opics in DNA Repair2011
- Author(s)
  Yoshida K
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-23300347
[Book] Role for PKCδon apoptosis in the DNA damage response. In: Clark C. Chen (ed)2011
- Author(s)
  Yoshida K
- Publisher
  Selected Topics in DNA Repair.InTech
- Data Source
  KAKENHI-PROJECT-23650612
[Book] Protein Kinase C in Cancer Signaling and Therapy.(PKC, p53, and DNA damage.)(Mrcelo KG (ed))2010
- Author(s)
  Yoshida K.
- Publisher
  Springer Science & Business Media.
- Data Source
  KAKENHI-PROJECT-20390091
[Book] Molecular Mechanisms of Cockayne Syndrome.(Cell signalling, cell cycle defect and apoptosis in Cockayne syndrome.)(Ahmad SI (ed))2009
- Author(s)
  Yoshida K.
- Publisher
  Landes Biosciences Publication.
- Data Source
  KAKENHI-PROJECT-20390091
[Book] Progress in DNA Damage Research.(Functional roles for pro-apoptotic kinases on nuclear targeting and induction of apoptosis in response to DNA damage.)(Miura S and Nakano S (eds))2008
- Author(s)
  Yoshida K.
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-20390091
[Book] Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage. Advances in Molecular Oncology. in 'Advances in Experimental Medicine and Biology' Vol. 6042007
- Author(s)
  Yoshida K
- Total Pages
  274
- Publisher
  Springer Science & Business Media
- Data Source
  KAKENHI-PROJECT-17689015
[Book] Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage. Advances in Molecular Oncology. in ‘Advances in Experimental Medicine and Biology' Vol.6042007
- Author(s)
  Yoshida K
- Total Pages
  274
- Publisher
  Springer Science & Business Media
- Data Source
  KAKENHI-PROJECT-19657038
[Journal Article] Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma2024
- Author(s)
  Harada Eriko、Yoshida Saishu、Imaizumi Yuta、Kawamura Akira、Ohtsuka Takashi、Yoshida Kiyotsugu
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1868 Issue: 6 Pages: 130600-130600
- DOI
  10.1016/j.bbagen.2024.130600
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18244, KAKENHI-PROJECT-21K06192
[Journal Article] Protein kinase C delta enhances the diagnostic performance of hepatocellular carcinoma.2024
- Author(s)
  Nakagawa C, Oikawa T , Yamada K, Tsubota A, Saeki C, Katagiri K, Tago N, Kamioka H, Ueda K, Haruki K, Furukawa K, Nakano M, Torisu Y, Ikegami T, Yoshida K, Saruta M
- Journal Title
  
  Biomarkers
  
  Volume: 29 Issue: 2 Pages: 55-67
- DOI
  10.1080/1354750x.2024.2312990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08063, KAKENHI-PROJECT-22K08587, KAKENHI-PROJECT-21K08718
[Journal Article] Protein Kinase C Delta Is a Novel Biomarker for Hepatocellular Carcinoma.2023
- Author(s)
  Oikawa T, Yamada K, Tsubota A, Saeki C, Tago N, Nakagawa C, Ueda K, Kamioka H, Taniai T, Haruki K, Nakano M, Torisu Y, Ikegami T, Yoshida K, and Saruta M.
- Journal Title
  
  Gastro Hep Advances
  
  Volume: 2 Issue: 1 Pages: 83-95
- DOI
  10.1016/j.gastha.2022.07.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08063, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621
[Journal Article] Extracellular PKCδ signals to epidermal growth factor receptor for tumor proliferation in liver cancer cells2022
- Author(s)
  Yamada Kohji、Kizawa Ryusuke、Yoshida Ayano、Koizumi Rei、Motohashi Saya、Shimoyama Yuya、Hannya Yoshito、Yoshida Saishu、Oikawa Tsunekazu、Shimoda Masayuki、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 7 Pages: 2378-2385
- DOI
  10.1111/cas.15386
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-23K24116
[Journal Article] DYRK2 maintains genome stability via neddylation of cullins in response to DNA damage2022
- Author(s)
  Kawamura Akira、Yoshida Saishu、Aoki Katsuhiko、Shimoyama Yuya、Yamada Kohji、Yoshida Kiyotsugu
- Journal Title
  
  Journal of Cell Science
  
  Volume: 135 Issue: 11
- DOI
  10.1242/jcs.259514
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06192, KAKENHI-PROJECT-20H03519
[Journal Article] Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B<sup>+</sup>vesicle pathway in liver cancer2022
- Author(s)
  Yamada Kohji、Motohashi Saya、Oikawa Tsunekazu、Tago Naoko、Koizumi Rei、Ono Masaya、Tachibana Toshiaki、Yoshida Ayano、Yoshida Saishu、Shimoda Masayuki、Oka Masahiro、Yoneda Yoshihiro、Yoshida Kiyotsugu
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 36
- DOI
  10.1073/pnas.2202730119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06192, KAKENHI-PROJECT-22K08063, KAKENHI-PROJECT-20H03444, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621, KAKENHI-PROJECT-23K24116
[Journal Article] Enforced dual‐specificity tyrosine‐regulated kinase 2 expression by adenovirus‐mediated gene transfer inhibits tumor growth and metastasis of colorectal cancer2022
- Author(s)
  Imaizumi Yuta、Yoshida Saishu、Kanegae Yumi、Eto Ken、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 3 Pages: 960-970
- DOI
  10.1111/cas.15247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K08195, KAKENHI-PROJECT-21K06192
[Journal Article] Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer2022
- Author(s)
  Yamada Kohji、Yoshida Kiyotsugu
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 28 Issue: 2 Pages: 188-198
- DOI
  10.3748/wjg.v28.i2.188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621
[Journal Article] Carbonic anhydrase 13 suppresses bone metastasis in breast cancer2021
- Author(s)
  Yogosawa Satomi、Nakayama Jun、Nishi Mayuko、Ryo Akihide、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Treatment and Research Communications
  
  Volume: 27 Pages: 100332-100332
- DOI
  10.1016/j.ctarc.2021.100332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-17K08672, KAKENHI-PROJECT-18K09000, KAKENHI-PROJECT-18K19484
[Journal Article] Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient2021
- Author(s)
  Yogosawa Satomi、Ohkido Makiko、Horii Takuro、Okazaki Yasumasa、Nakayama Jun、Yoshida Saishu、Toyokuni Shinya、Hatada Izuho、Morimoto Mitsuru、Yoshida Kiyotsugu
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1204-1204
- DOI
  10.1038/s42003-021-02734-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-21K06968
[Journal Article] Unconventional Secretion of PKCδ Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer2020
- Author(s)
  Yamada Kohji、Oikawa Tsunekazu、Kizawa Ryusuke、Motohashi Saya、Yoshida Saishu、Kumamoto Tomotaka、Saeki Chisato、Nakagawa Chika、Shimoyama Yuya、Aoki Katsuhiko、Tachibana Toshiaki、Saruta Masayuki、Ono Masaya、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 2 Pages: 414-425
- DOI
  10.1158/0008-5472.can-20-2009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07621, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-19K16781, KAKENHI-PROJECT-19K08429
[Journal Article] Impairment of DYRK2 by DNMT1?mediated transcription augments carcinogenesis in human colorectal cancer2020
- Author(s)
  Kumamoto Tomotaka、Yamada Kohji、Yoshida Saishu、Aoki Katsuhiko、Hirooka Shinichi、Eto Ken、Yanaga Katsuhiko、Yoshida Kiyotsugu
- Journal Title
  
  International Journal of Oncology
  
  Volume: 56 Pages: 1529-1539
- DOI
  10.3892/ijo.2020.5020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19484, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-19K16781, KAKENHI-PROJECT-17H03584, KAKENHI-PROJECT-20H03519
[Journal Article] Mechanical insights into the regulation of programmed cell death by p53 via mitochondria.2019
- Author(s)
  Kohji Yamada, Kiyotsugu Yoshida
- Journal Title
  
  Biochim Biophys Acta Mol Cell Res
  
  Volume: 1866 Issue: 5 Pages: 839-848
- DOI
  10.1016/j.bbamcr.2019.02.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18434, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-17H03584
[Journal Article] Multiple functions of DYRK2 in cancer and tissue development2019
- Author(s)
  Yoshida Saishu、Yoshida Kiyotsugu
- Journal Title
  
  FEBS Letters
  
  Volume: 593 Issue: 21 Pages: 2953-2965
- DOI
  10.1002/1873-3468.13601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19484, KAKENHI-PROJECT-19K16781, KAKENHI-PROJECT-17H03584
[Journal Article] Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer.2019
- Author(s)
  Yokoyama-Mashima S, Yogosawa S, Kanegae Y, Hirooka S, Yoshida S, Horiuchi T, Ohashi T, Yanaga K, Saruta M, Oikawa T, Yoshida K.
- Journal Title
  
  Cancer Lett
  
  Volume: 451 Pages: 100-109
- DOI
  10.1016/j.canlet.2019.02.046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09378, KAKENHI-PROJECT-16K18818, KAKENHI-PROJECT-19K08429, KAKENHI-PROJECT-17H03584
[Journal Article] Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis2018
- Author(s)
  Yogosawa Satomi、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 11 Pages: 3376-3382
- DOI
  10.1111/cas.13792
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08672, KAKENHI-PROJECT-17H03584
[Journal Article] Downregulation of dual-specificity tyrosine-regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin-dependent kinase 14 expression in breast cancer2018
- Author(s)
  Imawari Yoshimi、Mimoto Rei、Hirooka Shinichi、Morikawa Toshiaki、Takeyama Hiroshi、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 2 Pages: 363-372
- DOI
  10.1111/cas.13459
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03584, KAKENHI-PROJECT-18K16267
[Journal Article] 癌幹細胞の概念2017
- Author(s)
  三本麗、吉田清嗣
- Journal Title
  
  日本臨床
  
  Volume: 75増刊号3 Pages: 102-106
- Data Source
  KAKENHI-PROJECT-17H03584
[Journal Article] Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis2017
- Author(s)
  Kagami Yuya、Ono Masaya、Yoshida Kiyotsugu
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 5583-5583
- DOI
  10.1038/s41598-017-05986-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03584
[Journal Article] Impairment of DYRK2 augments stem-like traits by promoting KLF4 expression in breast cancer.2017
- Author(s)
  Mimoto R, Imawari Y, Hirooka S, Takeyama H, Yoshida K.
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 13 Pages: 1862-1872
- DOI
  10.1038/onc.2016.349
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290041
[Journal Article] A Novel Near-infrared Fluorescent Protein, iRFP720, Facilitates Transcriptional Profiling of Prostate Cancer Bone Metastasis in Mice.2017
- Author(s)
  Honda M, Yogosawa S, Kamada M, Kamata Y, Kimura T, Koike Y, Harada T, Takahashi H, Egawa S, Yoshida K.
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Pages: 3009-3013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03584
[Journal Article] Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer2017
- Author(s)
  Ito Daisuke、Yogosawa Satomi、Mimoto Rei、Hirooka Shinichi、Horiuchi Takashi、Eto Ken、Yanaga Katsuhiko、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 8 Pages: 1565-1573
- DOI
  10.1111/cas.13280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03584
[Journal Article] Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR.2017
- Author(s)
  Mimoto R, Nihira NT, Hirooka S, Takeyama H, Yoshida K.
- Journal Title
  
  Cancer Letters
  
  Volume: 384 Pages: 27-38
- DOI
  10.1016/j.canlet.2016.10.015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290041
[Journal Article] Downregulation of CD24 suppresses bone metastasis of lung cancer2017
- Author(s)
  Okabe Hinako、Aoki Katsuhiko、Yogosawa Satomi、Saito Mitsuru、Marumo Keishi、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 1 Pages: 112-120
- DOI
  10.1111/cas.13435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03584
[Journal Article] Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage.2016
- Author(s)
  Dashzeveg N, Yogosawa S, Yoshida K.
- Journal Title
  
  Cancer Letters
  
  Volume: 374 Issue: 1 Pages: 167-174
- DOI
  10.1016/j.canlet.2016.02.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290041
[Journal Article] Crosstalk between tumor suppressors p53 and PKC: Execution of the intrinsic apoptotic pathways.2016
- Author(s)
  Dashzeveg N, Yoshida K.
- Journal Title
  
  Cancer Letters
  
  Volume: 377 Issue: 2 Pages: 158-163
- DOI
  10.1016/j.canlet.2016.04.032
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290041
[Journal Article] Cell death decision by p53 via control of the mitochondrial membrane.2015
- Author(s)
  Dashzeveg N, Yoshida K.
- Journal Title
  
  Cancer Letters
  
  Volume: 367 Issue: 2 Pages: 108-112
- DOI
  10.1016/j.canlet.2015.07.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290041
[Journal Article] Engagement of DYRK2 in proper control for cell division.2015
- Author(s)
  Nihira NT, Yoshida K.
- Journal Title
  
  Cell Cycle
  
  Volume: 14 Issue: 6 Pages: 802-7
- DOI
  10.1080/15384101.2015.1007751
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25640080, KAKENHI-PROJECT-26290041, KAKENHI-PROJECT-26830083
[Journal Article] DYRK2 regulates epithelial-mesenchymal-transition and chemosensitivity through Snail degradation in ovarian serous adenocarcinoma.2015
- Author(s)
  Yamaguchi N, Mimoto R, Yanaihara N, Imawari Y, Hirooka S, Okamoto A, Yoshida K.
- Journal Title
  
  Tumor Biology
  
  Volume: 36 Issue: 8 Pages: 5913-5923
- DOI
  10.1007/s13277-015-3264-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290041
[Journal Article] Proteasome inhibitor-resistant cells cause EMT-induction via suppression of E-cadherin by miR-200 and ZEB1.2015
- Author(s)
  Asakura T, Yamaguchi N, Ohkawa K, Yoshida K.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 46 Issue: 5 Pages: 2251-2260
- DOI
  10.3892/ijo.2015.2916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290041
[Journal Article] Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage.2014
- Author(s)
  Dashzeveg N, Taira N, Lu ZG, Kimura J, Yoshida K.
- Journal Title
  
  Cell Death Dis
  
  Volume: 5 Issue: 5 Pages: e1221-e1221
- DOI
  10.1038/cddis.2014.176
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25640080, KAKENHI-PROJECT-26290041
[Journal Article] Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage2014
- Author(s)
  Taira N, Yamaguchi T, Kimura J, Lu Z-G, Fukuda S, Higashiyama S, Ono M, Yoshida K
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 111 Issue: 2 Pages: 717-722
- DOI
  10.1073/pnas.1313675111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300347, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24590382, KAKENHI-PUBLICLY-25112712, KAKENHI-PROJECT-25640080, KAKENHI-PROJECT-26290041, KAKENHI-PROJECT-26670143
[Journal Article] Mps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis.2014
- Author(s)
  Kagami Y, Nihira K, Wada S, Ono M, Honda M, Yoshida K.
- Journal Title
  
  J Cell Biol
  
  Volume: 205 Issue: 6 Pages: 781-90
- DOI
  10.1083/jcb.201308172
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25640080, KAKENHI-PROJECT-26290041
[Journal Article] Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage.2014
- Author(s)
  Nakazawa K, Dashzeveg N, Yoshida K.
- Journal Title
  
  FEBS J
  
  Volume: 281 Issue: 13 Pages: 2937-44
- DOI
  10.1111/febs.12831
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25640080, KAKENHI-PROJECT-26290041
[Journal Article] DYRK2 controls epithelial-mesenchymal transition in breast cancer by degrading Snail2013
- Author(s)
  Mimoto R, Taira N, Takahashi H, Yamaguchi T, Okabe M, Uchida K, Miki Y, Yoshida K
- Journal Title
  
  Cancer Lett
  
  Volume: 339 Issue: 2 Pages: 214-225
- DOI
  10.1016/j.canlet.2013.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300347, KAKENHI-PROJECT-24300328, KAKENHI-PUBLICLY-25134709, KAKENHI-PROJECT-25640080
[Journal Article] 抗腫瘍性キナーゼによる細胞周期制御とがんの進展2012
- Author(s)
  平直江、吉田清嗣
- Journal Title
  
  実験医学
  
  Volume: 30 Pages: 1786-1789
- Data Source
  KAKENHI-PROJECT-23650612
[Journal Article] Post-translational modifications of p53 tumor suppressor: determinants of its functional targets.2012
- Author(s)
  Taira N, Yoshida K
- Journal Title
  
  Histol. Histopathol.
  
  Volume: 27 Pages: 437-443
- Data Source
  KAKENHI-PROJECT-23650612
[Journal Article] PDCD6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage.2012
- Author(s)
  Suzuki K, Dashzeveg N, Lu Z-G, Taira N, Miki Y, Yoshida K
- Journal Title
  
  Cancer Sci.
  
  Volume: 103 Pages: 1788-1894
- Data Source
  KAKENHI-PROJECT-23650612
[Journal Article] DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells2012
- Author(s)
  Taira N., et al
- Journal Title
  
  The Journal of Clinical Investigation
  
  Volume: 122 Issue: 3 Pages: 859-872
- DOI
  10.1172/jci60818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00542, KAKENHI-PROJECT-23300347, KAKENHI-PROJECT-23650592, KAKENHI-PROJECT-23650612, KAKENHI-PUBLICLY-23117515, KAKENHI-PUBLICLY-23134503
[Journal Article] DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.2012
- Author(s)
  Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y, Yoshida K.
- Journal Title
  
  J Clin. Invest
  
  Volume: 122 Pages: 859-872
- Data Source
  KAKENHI-PROJECT-23650612
[Journal Article] Identification of Evi-1 as a novel effector of PKCδin the apoptotic response to DNA damage.2011
- Author(s)
  Hew HC, Liu H, Lu-Z-G, Kimura J, Miki Y, Yoshida K
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1803 Pages: 285-294
- Data Source
  KAKENHI-PROJECT-23650612
[Journal Article] Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage.2011
- Author(s)
  Kimura J, Kudoh T, Miki Y, Yoshida K.
- Journal Title
  
  Int.J.Cancer 128
  
  Pages: 1524-1531
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] PKCδregulates Mdm2 independently of p53 in the apoptotic response to DNA damage.2011
- Author(s)
  Hew HC, Liu H, Miki Y, Yoshida K
- Journal Title
  
  Mol. Carcinog.
  
  Volume: 50 Pages: 719-731
- Data Source
  KAKENHI-PROJECT-23650612
[Journal Article] 『アポトーシス誘導におけるPKC』「Surgery Frontier」18:62-65 (2011) 8, Kimura J, Kudoh T, Miki Y, Yoshida K. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage.2011
- Author(s)
  吉田清嗣
- Journal Title
  
  Int. J. Cancer
  
  Volume: 128 Pages: 1524-1531
- Data Source
  KAKENHI-PROJECT-23650612
[Journal Article] Pim1 controls NF-_κB signalling by stabilizing RelA/p65.2010
- Author(s)
  Nihira K, Ando Y, Yamaguchi T, Kagami Y, Miki Y, Yoshida K.
- Journal Title
  
  Cell Death Differ. 17
  
  Pages: 689-698
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage.2010
- Author(s)
  Kudoh T, Kimura J, Lu Z-G, Miki Y, Yoshida K.
- Journal Title
  
  Exp.Cell Res. 316
  
  Pages: 2849-2858
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] The cell death machinery governed by the p53 tumor suppressor in response to DNA damage.2010
- Author(s)
  Yoshida K, et al.
- Journal Title
  
  Cancer Science
  
  Volume: 101 Pages: 831-835
- NAID
  10026590305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage.2010
- Author(s)
  Yamaguchi T, Miki Y, Yoshida K.
- Journal Title
  
  Apoptosis 15
  
  Pages: 927-935
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] The cell death machinery governed by the p53 tumor suppressor in response to DNA damage.2010
- Author(s)
  Yoshida K, Miki Y.
- Journal Title
  
  Cancer Sci. 101
  
  Pages: 831-835
- NAID
  10026590305
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.2010
- Author(s)
  Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K.
- Journal Title
  
  J.Biol.Chem. 285
  
  Pages: 4909-4919
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] DNA damage signalling recruits RREB-1 to the p53 tumor suppressor promoter.2009
- Author(s)
  Liu H, Hew HC, Lu Z-G, Yamaguchi T, Miki Y, Yoshida K.
- Journal Title
  
  Biochem.J. 422
  
  Pages: 543-551
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] Protein kinase Cδ activates RelA/p65 and nuclear factor-κB signaling in response to tumor necrosis factor-α.2009
- Author(s)
  Lu Z-G, Liu H, Yamaguchi T, Miki Y, Yoshida K.
- Journal Title
  
  Cancer Res. 69
  
  Pages: 5927-5935
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] Nuclear trafficking of pro-apoptotic kinases in response to DNA damage.2008
- Author(s)
  Yoshida K.
- Journal Title
  
  Trends.Mol.Med. 14
  
  Pages: 305-313
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress.2008
- Author(s)
  Nihira K, Taira N, Miki Y, Yoshida K.
- Journal Title
  
  Oncogene 27
  
  Pages: 7285-7295
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] BRCA1-mediated ubiquitination inhibits topoisomerase IIα activity in response to oxidative stress.2008
- Author(s)
  Shinagawa H, Miki Y, Yoshida K.
- Journal Title
  
  Antioxid.Redox.Signal. 10
  
  Pages: 939-950
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress.2008
- Author(s)
  Kimura J, Nguyen ST, Liu H, Taira N, Miki Y, Yoshida K.
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 5250-5259
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] A novel BRCA2-interacting protein BJ-HCC-20A is involved in promotion of cell growth and in DNA repair in response to DNA damage.2008
- Author(s)
  Tomiyoshi G, Takenaka K, Yoshida K, Miki Y.
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 747-754
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] Role for DYRK family kinases on regulation of apoptosis.2008
- Author(s)
  Yoshida K.
- Journal Title
  
  Biochem.Pharmacol. 14
  
  Pages: 305-313
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] PKCdelta signaling : mechanisms of DNA damage response and apoptosis.2007
- Author(s)
  Yoshida, K.
- Journal Title
  
  Cellular Signalling 19
  
  Pages: 892-901
- Data Source
  KAKENHI-PROJECT-17689015
[Journal Article] Protein kinase C delta activates topoisomerase Halpha to induce apoptotic cell death in response to DNA damage.2006
- Author(s)
  Yoshida, K., et al.
- Journal Title
  
  Molecular and Cellular Biology 26
  
  Pages: 3414-3431
- Data Source
  KAKENHI-PROJECT-17689015
[Journal Article] Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage.2006
- Author(s)
  Yoshida, K., et al.
- Journal Title
  
  Molecular and Cellular Biology (in press)
- Data Source
  KAKENHI-PROJECT-17689015
[Journal Article] Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.2006
- Author(s)
  Yoshida, K., et al.
- Journal Title
  
  Journal of Biological Chemistry 281
  
  Pages: 5734-5740
- Data Source
  KAKENHI-PROJECT-17689015
[Journal Article] JNK phosphorylation of 14-3-3 regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.2005
- Author(s)
  Yoshida, K., et al.
- Journal Title
  
  Nature Cell Biology 7・3
  
  Pages: 278-285
- Data Source
  KAKENHI-PROJECT-15790163
[Journal Article] Death by the Abl Tyrosine Kinase : Mechanisms for Nuclear Shuttling of c-Abl in Response to DNA Damage.2005
- Author(s)
  Yoshida, K., et al.
- Journal Title
  
  Cell Cycle 4
  
  Pages: 777-779
- Data Source
  KAKENHI-PROJECT-17689015
[Journal Article] JNK phosphorylation of 14-3-3 regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.2005
- Author(s)
  Yoshida, K., et al.
- Journal Title
  
  Nature Cell Biology 7・3
  
  Pages: 278-285
- Data Source
  KAKENHI-PROJECT-16022222
[Journal Article] JNK phosphorylation of 14-3-3 regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.2005
- Author(s)
  Yoshida, K., et al.
- Journal Title
  
  Nature Cell Biology 7
  
  Pages: 278-285
- Data Source
  KAKENHI-PROJECT-17689015
[Journal Article] DNA損傷におけるAblチロシンキナーゼの核移行とアポトーシス誘導制御2005
- Author(s)
  吉田清嗣, et al.
- Journal Title
  
  実験医学 23
  
  Pages: 1916-1919
- Data Source
  KAKENHI-PROJECT-17689015
[Journal Article] Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage.2004
- Author(s)
  Yoshida, K., et al.
- Journal Title
  
  Cancer Sci. 95
  
  Pages: 866-887
- NAID
  10014197645
- Data Source
  KAKENHI-PROJECT-15790163
[Journal Article] 病気はどこまでゲノムで決められているか『癌』2004
- Author(s)
  吉田清嗣, 三木義男
- Journal Title
  
  MolecularMedicine 41・増刊
  
  Pages: 250-257
- Data Source
  KAKENHI-PROJECT-16022222
[Journal Article] 病気はどこまでゲノムで決められているか『癌』2004
- Author(s)
  吉田清嗣, 三木義男
- Journal Title
  
  MolecularMedicine 41・増刊
  
  Pages: 250-257
- Data Source
  KAKENHI-PROJECT-15790163
[Journal Article] Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage.2004
- Author(s)
  Yoshida, K., et al.
- Journal Title
  
  Cancer Sci. 95
  
  Pages: 866-887
- NAID
  10014197645
- Data Source
  KAKENHI-PROJECT-16022222
[Journal Article] 転写因子と癌II : BRCAと発癌2004
- Author(s)
  吉田清嗣, 三木義男
- Journal Title
  
  臨床検査 48
  
  Pages: 701-709
- Data Source
  KAKENHI-PROJECT-16022222
[Journal Article] SNPsと有害事象情報2004
- Author(s)
  吉田清嗣, 三木義男
- Journal Title
  
  現代医療 36
  
  Pages: 1347-1352
- Data Source
  KAKENHI-PROJECT-16022222
[Journal Article] SNPsと有害事象情報2004
- Author(s)
  吉田清嗣, 三木義男
- Journal Title
  
  現代医療 36
  
  Pages: 1347-1352
- Data Source
  KAKENHI-PROJECT-15790163
[Journal Article] 転写因子と癌II : BRCAと発癌2004
- Author(s)
  吉田清嗣, 三木義男
- Journal Title
  
  臨床検査 48
  
  Pages: 701-709
- Data Source
  KAKENHI-PROJECT-15790163
[Journal Article] PKCδ regulates Mdm2 independently of p53 in the apoptotic response to DNA damage.
- Author(s)
  Hew HC, Liu H, Miki Y, Yoshida K.
- Journal Title
  
  Mol.Carcinog. in press
- Data Source
  KAKENHI-PROJECT-20390091
[Journal Article] Identification of Evi-1 as a novel effector of PKCδ in the apoptotic response to DNA damage.
- Author(s)
  Hew HC, Liu H, Lu-Z-G, Kimura J, Miki Y, Yoshida K.
- Journal Title
  
  Biochim.Biophys.Acta in press.
- Data Source
  KAKENHI-PROJECT-20390091
[Presentation] 下垂体の発生における一次繊毛制御因子DYRK2の機能解析2023
- Author(s)
  吉田彩舟、河村明良、恒岡洋右、塚田岳大、中倉敬、Pattama Wiriyasermkul、山田幸司、永森収志、吉田清嗣
- Organizer
  第47回比較内分泌学会大会
- Data Source
  KAKENHI-PROJECT-23K18244
[Presentation] 一次繊毛制御因子DYRK2を介した下垂体の発生制御2023
- Author(s)
  吉田彩舟、河村明良、恒岡洋右、塚田岳大、中倉敬、Pattama Wiriyasermkul、山田幸司、永森収志、吉田清嗣
- Organizer
  第37回下垂体研究会学術集会
- Data Source
  KAKENHI-PROJECT-23K18244
[Presentation] がんで見られる型破り分泌と機構解明2022
- Author(s)
  小泉麗、山田幸司、吉田清嗣
- Organizer
  第95回生化学会大会
- Data Source
  KAKENHI-PROJECT-20H03519
[Presentation] Extracellular PKCd associates with EGF receptor for liver cancer proliferation2022
- Author(s)
  吉田彩乃、山田幸司、及川恒一、小泉麗、吉田清嗣
- Organizer
  第81回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-20H03519
[Presentation] Carbonic anhydrase 13 suppresses bone metastasis of breast cancer cells.2020
- Author(s)
  Satomi Yogosawa, Jun Nakayama, Mayuko Nishi, Akihide Ryo, Kiyotsugu Yoshida
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K19484
[Presentation] Carbonic anhydrase 13 suppresses bone metastasis of breast cancer cells.2020
- Author(s)
  Yogosawa S, Nakayama J, Nishi M, Ryo A, Yoshida K.
- Organizer
  第７９回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08672
[Presentation] DYRK2欠損マウスは先天性奇形症候群の疾患モデルとなる2020
- Author(s)
  與五沢里美、吉田清嗣
- Organizer
  2019年度先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-17K08672
[Presentation] Carbonic anhydrase 13 suppresses bone metastasis of breast cancer cells.2020
- Author(s)
  Satomi Yogosawa, Jun Nakayama, Mayuko Nishi, Akihide Ryo, Kiyotsugu Yoshida
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03519
[Presentation] DYRK2欠損マウスは肺低形成により呼吸不全となり、出生直後致死となる2019
- Author(s)
  與五沢里美、吉田清嗣
- Organizer
  平成30年度先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-17K08672
[Presentation] 肝がんにおけるDYRK2の強制発現はアポトーシスの誘導を介して抗腫瘍効果を発揮する2019
- Author(s)
  横山志保、與五沢里美、吉田彩舟、吉田清嗣
- Organizer
  第７８回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03584
[Presentation] DYRK2のメチル化を標的とした大腸癌治療の可能性2019
- Author(s)
  隈本智卓、山田幸司、青木勝彦、吉田清嗣、矢永勝彦
- Organizer
  第７４回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-17H03584
[Presentation] 乳癌細胞株においてDYRK2はCDK14を介して腫瘍増殖を制御する2018
- Author(s)
  井廻良美、三本麗、山口乃里子、武山浩、吉田清嗣
- Organizer
  第７７回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03584
[Presentation] 肝癌におけるDYRK2の関与2018
- Author(s)
  間嶋志保、及川恒一、與五沢里美、吉田清嗣、猿田雅之
- Organizer
  第25回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-16K09378
[Presentation] DYRK2のプロモーター領域のメチル化は人の結腸直腸癌の進行を制御する2018
- Author(s)
  隈本智卓、山田幸司、青木勝彦、矢永勝彦、吉田清嗣
- Organizer
  第７７回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03584
[Presentation] RNF8とDYRK2の相互作用はDNA二本鎖切断部位へのDNA修復因子のリクルートを制御する2017
- Author(s)
  山本武徳、仁平直江、與五沢里美、青木勝彦、吉田清嗣
- Organizer
  第７５回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03584
[Presentation] Tumor suppressive function of DYRK2.2017
- Author(s)
  Yoshida K.
- Organizer
  DYRK1A, related kinases and human disease.
- Place of Presentation
  Saint Malo, France
- Year and Date
  2017-03-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290041
[Presentation] DYRK2 contributes to the generation of breast cancer stem cells through KLF4.2016
- Author(s)
  Imawari Y, Mimoto RK, Yamaguchi N, Yoshida K.
- Organizer
  10th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association.
- Place of Presentation
  Maui, HI
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290041
[Presentation] DYRK2 phosphorylation of c-Jun/c-Myc controls tumor progression by monitoring G1/S transition.2013
- Author(s)
  Yoshida K
- Organizer
  1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling.
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] DYRK2 phosphorylation of c-Jun/c-Myc controls tumor progression by monitoring G1/S transition.2013
- Author(s)
  Kiyotsugu Yoshida
- Organizer
  1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
- Place of Presentation
  Tokyo, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] Identification of a novel mechanism for apoptosis and microRNA metabolism in response to genotoxic stress2013
- Author(s)
  Taira N, Kimura J, Lu Z-G, Yamaguchi T, Yoshida K
- Organizer
  9th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
- Place of Presentation
  Maui, Hawaii
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] The comprehensive study for the target genes of the Serine 46 phosphorylation of the p53.2013
- Author(s)
  Dashzeveg N, Taira N, Miki Y, Yoshida K
- Organizer
  9th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
- Place of Presentation
  Maui, Hawaii
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] DYRK2 phosphorylation of c-Jun/c-Myc controls tumor progression by monitoring G1/S transition.2013
- Author(s)
  Kiyotsugu Yoshida
- Organizer
  1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
- Place of Presentation
  Tokyo, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23300347
[Presentation] DYRK2 phosphorylation of c-Jun/c-Myc controls tumor progression by monitoring G1/S transition.2013
- Author(s)
  Kiyotsugu Yoshida
- Organizer
  1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2013-02-01
- Invited
- Data Source
  KAKENHI-PUBLICLY-23117515
[Presentation] DYRK2-mediated phosphorylation of c-Jun and c-Myc is requisite for proper control of the G1/S transition2012
- Author(s)
  Taira N, Mimoto R, Miki Y, Yoshida K
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  Chicago, IL
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] Role for DYRK2 in cell cycle control and tumor progression.2012
- Author(s)
  Kiyotsugu Yoshida
- Organizer
  MMC2012
- Place of Presentation
  Bangkok, Thailand
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] Role for DYRK2 in cell cycle control and tumor progression.2012
- Author(s)
  Kiyotsugu Yoshida
- Organizer
  MMC2012
- Place of Presentation
  Bangkok, Thailand
- Data Source
  KAKENHI-PROJECT-23300347
[Presentation] DYRK2 regulates cancer invasiveness via Snail/E-cadherin pathway2012
- Author(s)
  Mimoto R, Taira N, Miki Y, Yoshida K
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  Chicago, IL
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] 細胞死誘導と細胞周期制御による発癌抑制の分子機構2012
- Author(s)
  吉田清嗣
- Organizer
  第3次対がん10か年総合戦略・文科省がん支援活動合同公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-01-31
- Data Source
  KAKENHI-PUBLICLY-23117515
[Presentation] DYRK2 regulates breast cancer invasion via Snail/E-cadherin pathway2012
- Author(s)
  Mimoto R, Imawari Y, Kamio M, Kato K, Nogi H, Toriumi Y, Takeyama H, Yoshida K,Uchida K
- Organizer
  The 2012 CTRC-AACR San Antonio Breast Cancer Symposium
- Place of Presentation
  San Antonio, TX
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] 細胞死誘導と細胞周期制御による発癌抑制の分子機構2012
- Author(s)
  吉田清嗣
- Organizer
  第3次対がん10か年総合戦略・文科省がん支援活動合同公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-01-31
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] 細胞死誘導と細胞周期制御による発癌抑制の分子機構2012
- Author(s)
  吉田清嗣
- Organizer
  第3次対がん10か年総合戦略・文科省がん支援活動合同公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-01-31
- Data Source
  KAKENHI-PROJECT-23300347
[Presentation] 細胞死誘導と細胞周期制御による発癌抑制の分子機構2012
- Author(s)
  吉田清嗣
- Organizer
  第3次対がん10か年総合戦略・文科省がん支援活動合同公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-01-31
- Data Source
  KAKENHI-PROJECT-23300347
[Presentation] Role for DYRK2 in cell cycle control and tumor progression.2012
- Author(s)
  Kiyotsugu Yoshida
- Organizer
  MMC2012
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2012-12-19
- Data Source
  KAKENHI-PUBLICLY-23117515
[Presentation] Role for DYRK2 in cell cycle control and tumor progression2012
- Author(s)
  Yoshida K
- Organizer
  Siriaj Medical Journal 64: Suppl. 2, Nov-Dec. 61. (2012) MMC2012.
- Place of Presentation
  Bangkok, Thailand
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] Discovery of the pro-apoptotic genes induced by tumor suppressor p532012
- Author(s)
  Dashzeveg N, Taira N, Miki Y, Yoshida K
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  Chicago, IL
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] アポトーシス誘導の制御機構2011
- Author(s)
  吉田清嗣
- Organizer
  第26回生体・生理工学シンポジウム/「バイオシグナルの統合と治療応用に関する研究会」第21回研究会
- Place of Presentation
  草津、滋賀
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] Amphiregulin, a novel target of p53, modulates microRNA metabolism in the nucleus.2011
- Author(s)
  Taira N, Kimura J, Lu Z-G, Yamaguchi T, Higashiyama S, Ono M, Miki Y, Yoshida K
- Organizer
  'Signal Transduction within the Nucleus', Gordon Research Conference.
- Place of Presentation
  Ventura, CA
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] PKCδcontrols Evi-1 to transactivate PLZF in the apoptotic response to DNA damage2011
- Author(s)
  Hew HC, Liu H, Lu-Z-G, Kimura J, Miki Y, Yoshida K
- Organizer
  'Signal Transduction within the Nucleus', Gordon Research Conference.
- Place of Presentation
  Ventura, CA
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] リン酸化依存性アポトーシス誘導における転写指向性と分子機構BMB2010(ワークショップ;「p53ワールド」2010
- Author(s)
  吉田清嗣
- Organizer
  その多彩な生理作用～複雑なシグナルネットワークから疾患病態生理まで～p53
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-20390091
[Presentation] Role for DYRK2 on induction of apoptosis in response to DNA damage2009
- Author(s)
  吉田清嗣
- Organizer
  The Joint Symposium of the 4th International Symposium of Institutes Network and Osaka University Global COE (Frontier Biomedical Science Underlying Organelle Network Biology) Symposium
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-20390091
[Presentation] PKCdelta activates RelA/p65 and NF-kappaB signalling to prevent TNFalpha-induced apoptosis.2009
- Author(s)
  Lu Z-G, Liu H, Yamaguchi T, Miki Y, Yoshida K
- Organizer
  17th ECDO Euroconference on Apoptosis
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-20390091
[Presentation] DNA傷害性アポトーシス誘導におけるp53のリン酸化とその意義2009
- Author(s)
  吉田清嗣
- Organizer
  第32回日本分子生物学会年会(ワークショップ;p53研究のニューパラダイム)
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20390091
[Presentation] A genome-wide RNAi screen identifies TAF1 as an apoptosis modulator that implies a potential therapeutic target. Annals Oncol.20 (Suppl.3) : iii36, 2009.2009
- Author(s)
  吉田清嗣
- Organizer
  7th International Symposium on Targeted Anticancer Therapies 2009
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-20390091
[Presentation] A novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage.2008
- Author(s)
  Tomiyoshi G, Nakanishi A, Takenaka K, Yoshida K, Miki Y.
- Organizer
  Second JCA-AACR Special Joint Conference
- Place of Presentation
  Hyogo, Japan
- Data Source
  KAKENHI-PROJECT-20390091
[Presentation] A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress.2008
- Author(s)
  Kimura J, Nguyen ST, Liu H, Taira N, Miki Y, Yoshida K
- Organizer
  Second JCA-AACR Special Joint Conference
- Place of Presentation
  Hyogo, Japan
- Data Source
  KAKENHI-PROJECT-20390091
[Presentation] DNA傷害におけるシグナル伝達機構とアポトーシス誘導2008
- Author(s)
  吉田清嗣
- Organizer
  第12回Molecular Cardiovascular Conference
- Place of Presentation
  北海道
- Year and Date
  2008-09-07
- Data Source
  KAKENHI-PROJECT-20390091
[Presentation] DYRK2 induces apoptosis via p53 phosphorylation at Ser46 in response to DNA damage.2008
- Author(s)
  吉田清嗣
- Organizer
  Apoptosis World 2008
- Place of Presentation
  Luxembourg, Luxembourg
- Data Source
  KAKENHI-PROJECT-20390091
[Presentation] DNA傷害における細胞内シグナル伝達機構とアポトーシス誘導メカニズム2007
- Author(s)
  吉田清嗣
- Organizer
  BMB2007
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-17689015
[Presentation] DNA傷害における細胞内シグナル伝達機構とアポトーシス誘導メカニズム2007
- Author(s)
  吉田清嗣
- Organizer
  BMB2007
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19657038
[Presentation] 細胞死誘導と細胞周期制御による発癌抑制の分子機構
- Author(s)
  吉田清嗣
- Organizer
  第３次対がん１０か年総合戦略・文科省がん支援活動　合同公開シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23650612
[Presentation] The phosphorylation of p53 at ser46 is essential to induce cell death through palmedlphin in response to DNA damage.
- Author(s)
  Dashzeveg N, Yoshida K.
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, PA
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-25640080
[Presentation] The phosphorylation of p53 at ser46 is essential to induce cell death through palmedlphin in response to DNA damage.
- Author(s)
  Dashzeveg N, Yoshida K.
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, PA
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-26290041
[]

1. Oikawa Tsunekazu (20514491)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. Yogosawa Satomi (60392437)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 大熊誠尚 (30366207)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 衛藤謙 (00287210)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 小菅誠 (60372968)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 坪田昭人 (90322643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 吉田彩舟 (40772744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. 武田泰裕 (40817136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Mashima Shiho

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 立花利公

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 山田幸司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yoshida Kiyotsugu 吉田 清嗣

YOSHIDA Kiyotsugu 吉田 清嗣

Research Projects

Research Products

Co-Researchers

Functional analysis of PKC delta in distant metastasis of colorectal cancer

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一次繊毛と細胞外小胞分泌を特性とするがん幹細胞の新規概念創出とその生物学的意義Principal Investigator

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リン酸化酵素DYRK2を介する大腸癌リンパ節転移の機序解明と革新的治療法開発

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肝癌特異的な細胞外分泌蛋白を用いた新規早期診断法確立とその実用化に向けた検証研究

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Elucidation for molecular mechanism of carcinogenesis driven by cancer stem cellsPrincipal Investigator

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Gene therapy development in liver cancer

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Elucidation for molecular mechanism of cancer stem cells by the live-imaging technologyPrincipal Investigator

Principal Investigator

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Molecular mechanism of tumor progression by the regulation of glucose and lipid metabolism

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Molecular mechanism of tumor metastasis driven by cancer stem cellsPrincipal Investigator

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The role of DYRK2 in primary liver cancers

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Molecular mechanisms of cancer stem cells for neoplastic cellular transformationPrincipal Investigator

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Comprehensive identification of tumor-targeting molecules based on the quantitative proteome analysisPrincipal Investigator

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プライミングリン酸化反応の制御機構とその破綻による病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Yoshida Kiyotsugu 吉田清嗣

YOSHIDA Kiyotsugu 吉田清嗣