MAKISHIMA Makoto 槇島誠

… Alternative Names

槇島誠マキシママコト

愼島誠マキシママコト

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Researcher Number	70346146
Other IDs
Affiliation (Current)	2025: 日本大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 日本大学, 医学部, 教授 2004 – 2019: 日本大学, 医学部, 教授 2003: 大阪大学, 生命機能研究科, 助教授
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Biological Sciences / Basic Section 49010:Pathological biochemistry-related / General medical chemistry Except Principal Investigator Pathological medical chemistry / Biological Sciences / General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator ビタミンD受容体 / 胆汁酸 / リトコール酸 / 炎症 / LXR / 肝障害 / NKT細胞 / 代謝 / コレステロール / 核内レセプター … More / VDR / ビタミンD誘導体 / サイトカイン / 肝臓 / クッパ－細胞 / NK細胞 / マクロファージ / インターロイキン6 / 胆汁鬱滞 / 脂質 / 遺伝子 / 核内受容体 / β-カテニン / 転写因子 / 大腸がん / 免疫細胞 / 急性肝炎 / 生理活性 / シグナル伝達 / 栄養学 / 免疫学 / 大腸炎 / ケノデオキシコール酸 / 肝炎 / 貪食能 / 活性酸素種 / Kupffer細胞 / cholestasis / transcription / metabolism / plant sterol / bile acid / nuclear receptor / エルゴステロール / ABCトランスポーター / PXR / FXR / RXR / 胆汁うっ滞 / 転写 / 植物ステロール / 自然免疫 / クッパ-細胞 / 急性肝障害 / ビリルビン / ノックアウトマウス / 転写調節 / 強心ステロイド / CYP1 / ビタミン / 脂質代謝 / 時計遺伝子 / 重力 / ビタミンD / コファクター / CYP1A1 / ダイオキシン受容体 / モーダルシフト / セルセンサー / 発現制御 / 蛋白質 / オキシステロール / 遺伝子発現 … More Except Principal Investigator 核内受容体 / 肥満 / RhoA / 転写因子 / ビタミンD / 腸内細菌 / 胆汁酸 / Nitrie Oxide(NO) / endoplasmic reticulum (ER) stress / Hypoxia / Catalase / Reactive Oxygen Species(ROS) / adiponectin promoter / adiponectin / 転写共役因子 / LRH-1 / アディポサイトカイン / エネルギー消費 / ミトコンドリア / PTEN / PPARγ / Rhoキナーゼ / 脂肪細胞 / ピオグリタゾン / 一酸化窒素 / 小胞体ストレス / 低酸素 / カタラーゼ / 酸化ストレス / アディポネクチンプロモーター / アディポネクチン / 厚朴 / 天然物 / LXR / honokiol / 漢方方剤 / RXR / レチノイド / 動脈硬化 / メタボリックシンドローム / 天然物化学 / 生薬学 / 東洋医学 / PYY / VDR / ペプチドホルモン / 組織特異的 / 膵臓 / ビタミンD受容体 / 標的遺伝子 / 膵臓学 / 分子病態学 / 環境 / 支援 / 分子メカニズム / 生存 / 細胞 / センサー / 遺伝子改変 / 分子 / 機器管理 / 研究支援 / モーダルシフト / 2光子顕微鏡 / 細胞感覚 / 遺伝子改変動物 / 2光子励起顕微鏡 / セルソーター / セルセンサー / 支援活動 Less

The role of vitamin D receptor of hepatic immune cells in the pathogenesis of nonviral liver diseasePrincipal Investigator
- Principal Investigator
  
  槇島誠
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Nihon University
Regulation of intestinal and hepatic immunity by vitamin D receptor signalingPrincipal Investigator
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
The relationship between vitamin D signaling and bile acid metabolism in obesity mice.
- Principal Investigator
  
  ISHIZAWA Michiyasu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
Regulation of intestinal and hepatic immunity and metabolism by vitamin D receptorPrincipal Investigator
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
Clarify the meaning of Magnolia obovata in Kampo medicine on nuclear receptor activation.
- Principal Investigator
  
  KOTANI Hitoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Keio University
  Aichi Gakuin University
Regulation of inflammation and metabolism by vitamin Dreceptor in hepatic immune cellsPrincipal Investigator
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
Molecular mechanism of regulation of expression and identificati on of novel target gene of vitamin D in the pancreas
- Principal Investigator
  
  CHOI Mihwa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
Dynamic regulation of metabolite-sensing nuclear receptorsPrincipal Investigator
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nihon University
Cell sensor and its model shift
- Principal Investigator
  
  NABEKURA Junichi
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
大腸がん発症機構における脂質応答性核内レセプターの機能解析Principal Investigator
- Principal Investigator
  
  槇島誠
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nihon University
大腸がん発症機構における脂質応答性核内レセプターの機能解析Principal Investigator
- Principal Investigator
  
  槇島誠
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Regulation of the expression of adipocytokines and a novel therapeutic strategy for a metabolic syndrome
- Principal Investigator
  
  KOMURO Ryutaro, 下村伊一郎
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Regulation of bile acid metabolism by nuclear receptorsPrincipal Investigator
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nihon University
  Osaka University

[Book] 核内レセプターによるコレステロール胆汁酸代謝調節 - 食習慣を監視する分子メカニズム2005
- Author(s)
  槇島誠
- Publisher
  日本消化器病学会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Book] Nuclear receptors sense bile acid metabolism : a hormonal action of bile acids. In : Morikawa K., and Tate, S. (eds) Functional and structural biology on the lipo-network
- Author(s)
  Makoto Makishima
- Publisher
  Research Signpost (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Concanavalin A-induced acute hepatitis is attenuated in vitamin D receptor knockout mice with decreased immune cell function2019
- Author(s)
  Naoki Umeda,　Kaori Endo-Umeda, Hiroyuki Nakashima, Shigeaki Kato, Shuhji Seki, and Makoto Makishima
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 106 Issue: 4 Pages: 791-801
- DOI
  10.1002/jlb.3hi0219-048r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08632
[Journal Article] Lithocholic acid is a vitamin D receptor ligand that acts preferentially in the ileum2018
- Author(s)
  Michiyasu Ishizawa, Daisuke Akagi, and Makoto Makishima
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 7 Pages: 1975-1975
- DOI
  10.3390/ijms19071975
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08632, KAKENHI-PROJECT-16K19062
[Journal Article] Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα)2018
- Author(s)
  Yurina Miyashita, Nobutaka Numoto, Sundaram Arulmozhiraja, Shogo Nakano, Naoya Matsuo, Kanade Shimizu, Osamu Shibahara, Michiko Fujiwara, Hiroki Kakuta, Sohei Ito, Teikichi Ikura, Nobutoshi Ito, Hiroaki Tokiwa
- Journal Title
  
  FEBS Letters
  
  Volume: 593(2) Issue: 15 Pages: 242-250
- DOI
  10.1021/acs.jmedchem.8b00427
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0010, KAKENHI-PROJECT-16K08632
[Journal Article] Control of inflammatory bowel disease and colorectal cancer by synthetic vitamin D receptor ligands2016
- Author(s)
  Ichiro Takada, Makoto makishima
- Journal Title
  
  Current Medicinal Chemistry
  
  Volume: 23 Issue: 9 Pages: 868-875
- DOI
  10.2174/0929867323666161202145509
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08632
[Journal Article] Therapeutic application of vitamin D receptor ligands: an updated patent review2015
- Author(s)
  Ichiro Takada, and Makoto Makishima
- Journal Title
  
  Expert Opinion on Therapeutic Patents
  
  Volume: 25 Issue: 12 Pages: 1373-1383
- DOI
  10.1517/13543776.2015.1093113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460394
[Journal Article] Synthesis, Biological Activities and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds2015
- Author(s)
  Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C. M. Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mourino, Hiroaki Tokiwa, Makoto Makishima, and Sachiko Yamada
- Journal Title
  
  J.Med.Chem.
  
  Volume: 58 (24) Issue: 24 Pages: 9510-9521
- DOI
  10.1021/acs.jmedchem.5b00792
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460157, KAKENHI-PROJECT-25460394
[Journal Article] Combination of Triple Bond and Adamantane Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D Receptor2014
- Author(s)
  Takeru Kudo, Michiyasu, Ishizawa, Kazuki Maekawa, Makoto Nakabayashi, Yusuke Watarai, Hikaru Uchida, Hiroaki Tokiwa, Teikichi Ikura, Nobutoshi Ito, Makoto Makishima, Sachiko Yamada,
- Journal Title
  
  J. Med. Chem.
  
  Volume: 57(10) Issue: 10 Pages: 4073-4087
- DOI
  10.1021/jm401989c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460157, KAKENHI-PROJECT-25460394
[Journal Article] Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null mice.2012
- Author(s)
  Ishizawa M, Ogura M, Kato S, and Makishima M.
- Journal Title
  
  PLoS ONE
  
  Volume: 7(12) Issue: 12 Pages: e51664-e51664
- DOI
  10.1371/journal.pone.0051664
- NAID
  110009807289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590294
[Journal Article] Vitamin D receptor activation induces peptide YY transcription in pancreatic islets.2012
- Author(s)
  Choi M, Ozeki J, Hashizume M, Kato S, Ishihara H, Makishima M
- Journal Title
  
  Endocrinology
  
  Volume: 153 (11) Issue: 11 Pages: 5188-5199
- DOI
  10.1210/en.2012-1396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590295
[Journal Article] Vitamin D Receptor Activation Induces Peptide YY Transcription in Pancreatic Islets2012
- Author(s)
  Choi Mihwa, Ozeki Jun, Hashizume Masami, Kato Shigeaki, Ishihara Hisamitsu, Makishima Makoto
- Journal Title
  
  Endocrinology
  
  Volume: Vol.153、No.11 Pages: 5188-5199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590295
[Journal Article] Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice.2011
- Author(s)
  Ozeki J, Uno S, Ogura M, Choi M, Maeda T, Sakurai K, Matsuo S, Amano S, Nebert DW, Makishima M.
- Journal Title
  
  Toxicology 280
  
  Pages: 10-17
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] 胆汁酸代謝とビタミンD受容体2011
- Author(s)
  槇島誠
- Journal Title
  
  ビタミン
  
  Volume: 85 Pages: 47-56
- NAID
  110008460669
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Hypergravity modulates vitamin D receptor target gene mRNA expression in mice.2009
- Author(s)
  Ishizawa M, Iwasaki K, Kato S, Makishima M.
- Journal Title
  
  Am J Physiol Endocrinol Metab 297
- NAID
  110008686091
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Vitamin D3 modulates the expression of bile acid regulatory genes and represses inflammation in bile duct-ligated mice.2009
- Author(s)
  Ogura M, Nishida S, Ishizawa M, Sakurai K, Shimizu M, Matsuo S, Amano S, Uno S, Makishima M.
- Journal Title
  
  J Pharmacol Exp Ther 328
  
  Pages: 564-570
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells.2009
- Author(s)
  Amano Y, Cho Y, Matsunawa M, Komiyama K, Makishima M.
- Journal Title
  
  J Steroid Biochem Mol Biol 114
  
  Pages: 144-151
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Modulation of bile acid metabolism by 1alpha-hydroxyvitamin D3 administration in mice.2009
- Author(s)
  Nishida S, Ozeki J, Makishima M.
- Journal Title
  
  Drug Metab Disp 37
  
  Pages: 2037-2044
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Suppression of beta-catenin signaling by liver X receptor ligands.2009
- Author(s)
  Uno S, Endo K, Jeong Y, Kawana K, Miyachi H, Hashimoto Y, Makishima M.
- Journal Title
  
  Biochem Pharmacol 77
  
  Pages: 186-195
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] The basic helix-loop-helix proteins DEC1 and DEC2 function as corepressors of retinoid X receptors.2009
- Author(s)
  Cho Y, Noshiro M, Choi M, Morita M, Kawamoto T, Fujimoto K, Kato Y, Makishima M.
- Journal Title
  
  Mol Pharmacol 76
  
  Pages: 1360-1369
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Suppression of beta-catenin signaling by liver X receptor ligands.2009
- Author(s)
  Uno S, Endo K, Jeong Y, Kawana K, Miyachi H, Hashimoto Y, Makishima M
- Journal Title
  
  Biochem Pharmacol 77
  
  Pages: 186-195
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells.2009
- Author(s)
  Amano Y, Cho Y, Matsunawa M, Komiyama K, Makishima M
- Journal Title
  
  J Steroid Biochem Mol Biol 114
  
  Pages: 144-151
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.2009
- Author(s)
  Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M.
- Journal Title
  
  Toxicol Sci 10
  
  Pages: 50-58
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene.2008
- Author(s)
  Endo K, Uno S, Seki T, Ariga T, Kusumi Y, Mitsumata M, Yamada S, Makishima M.
- Journal Title
  
  Toxicol Appl Pharmacol 230
  
  Pages: 135-143
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.2008
- Author(s)
  Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M.
- Journal Title
  
  J Lipid Res 49
  
  Pages: 763-772
- NAID
  110007575062
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.2008
- Author(s)
  Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M
- Journal Title
  
  J Lipid Res 49
  
  Pages: 763-772
- NAID
  110007575062
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators.2007
- Author(s)
  Inaba Y, Yamamoto K, Yoshimoto N, Matsunawa M, Uno S, Yamada S, Makishima M
- Journal Title
  
  Mol Pharmacol 71
  
  Pages: 1298-1311
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators.2007
- Author(s)
  Inaba Y, Yamamoto K, Yoshimoto N, Matsunawa M, Uno S, Yamada S, Makishima M.
- Journal Title
  
  Mol Pharmacol 71
  
  Pages: 1298-1311
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Regulation of cholesterol and bile acid metabolism by nuclear receptors2005
- Author(s)
  Makishima, M.
- Journal Title
  
  Journal of Pharmacological Science 97
  
  Pages: 177-183
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Enhancement of ligand-dependent vitamin D receptor transzctivaton by the cardiotonic steroid bufalin2005
- Author(s)
  Nakano, H., Matsunawa, M., Yasui, A., Adachi, R., Kawana, K., Shimonura, I., Makishima, M.
- Journal Title
  
  Biochemical Pharmacology 70
  
  Pages: 1479-1486
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative2005
- Author(s)
  Adachi, R., Honma, Y., Masuno, H., Kawana, K., Shimonura, I., Yamada, S., Makishima, M.
- Journal Title
  
  Journal of Lipid Research 46
  
  Pages: 46-57
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Targeting the vitamin D receptor : advances in drug discovery2005
- Author(s)
  Makishima, M., Yamada, S.
- Journal Title
  
  Expert Opinion on Therapeutic Patents 15
  
  Pages: 1133-1145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Regulation of xenobiotic metabolism by xenobiotic receptors and cytochrome P450 enzymes2005
- Author(s)
  Uno, S., Makishima, M.
- Journal Title
  
  Nihon University School of Medicine 47
  
  Pages: 69-79
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Selective allosteric ligand activation of the retinoid X receptor heterodimaers of NGF-B and Nurr12005
- Author(s)
  Morita, K., Kawana, K., Sodeyama, M., Shimomura, I., Kagechika, H., Makishima, M.
- Journal Title
  
  Biochemical Pharmacology 71
  
  Pages: 98-107
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Targeting the vitamin D receptor : advances in drug discovery2005
- Author(s)
  Makoto Makishima
- Journal Title
  
  Expert Opinion on Therapeutic Patents 15・9
  
  Pages: 1133-1145
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Regulation of cholesterol and bile acid metabolism by nuclear receptors2005
- Author(s)
  Makoto Makishima
- Journal Title
  
  Journal of Pharmacological Sciences 97・2
  
  Pages: 177-183
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals2004
- Author(s)
  Adachi, R., Shulman, A.I., Yamamoto, K., Shimomura, I., Yamada, S., Mangelsdorf, D.J., Makishima, M.
- Journal Title
  
  Molecular Endocrinology 18
  
  Pages: 23-52
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Induction of intetinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist2003
- Author(s)
  Kaneko, E., Matsuda, M., Yamada, Y., Tachibana, Y., Shimonura, I., Makishima, M.
- Journal Title
  
  Journal of Biological Chemistry 278
  
  Pages: 36091-36098
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] Regulation of cholesterol and bile acid metabolism by nuclear receptors
- Author(s)
  Makoto Makishima
- Journal Title
  
  Journal of Pharmacological Sciences (In press)
- Data Source
  KAKENHI-PROJECT-16021228
[Journal Article] Regulation of cholesterol and bile acid metabolism by nuclear receptors
- Author(s)
  Makoto Makishima
- Journal Title
  
  Journal of Pharmacological Sciences (In press)
- Data Source
  KAKENHI-PROJECT-15390091
[Journal Article] The aryl hydrocarbon receptor activator benzo [a] pyrene enhances vitamin D3 catabolism in macrophages.
- Author(s)
  Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M
- Journal Title
  
  Toxicol Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] パーシャルアゴニスト活性を持つ新規ビタミンD受容体モジュレーター2011
- Inventor(s)
  槇島誠、山田幸子、常盤広明、工藤健
- Industrial Property Rights Holder
  学校法人日本大学、学校法人立教学院
- Industrial Property Number
  2011-045022
- Filing Date
  2011-03-02
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] パーシャルアゴニスト活性を持つ新規ビタミンD受容体モジュレーター2011
- Inventor(s)
  槇島誠
- Industrial Property Rights Holder
  日本大学
- Filing Date
  2011-03-02
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] 作用選択的ビタミンD受容体作用剤2009
- Inventor(s)
  槇島誠
- Industrial Property Rights Holder
  日本大学
- Filing Date
  2009-11-25
- Overseas
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] 作用選択的ビタミンD受容体作用剤2009
- Inventor(s)
  槇島誠
- Industrial Property Rights Holder
  日本大学
- Filing Date
  2009-12-01
- Overseas
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] 作用選択的ビタミンD 受容体作用剤2008
- Inventor(s)
  槇島誠、石澤通康、松縄学、山田幸子
- Industrial Property Rights Holder
  学校法人日本大学
- Filing Date
  2008-01-07
- Overseas
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] 特許2008
- Inventor(s)
  愼島誠、他
- Industrial Property Rights Holder
  日本大学
- Filing Date
  2008-01-07
- Overseas
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] 特許2007
- Inventor(s)
  愼島誠、他
- Industrial Property Rights Holder
  日本大学
- Industrial Property Number
  2007-147866
- Filing Date
  2007-06-04
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] 作用選択的ビタミンD受容体作用剤2007
- Inventor(s)
  槇島誠、石澤通康、松縄学、山田幸子
- Industrial Property Rights Holder
  学校法人日本大学
- Industrial Property Number
  2007-147866
- Filing Date
  2007-06-04
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] 肝臓免疫細胞におけるVDR依存性の機能発現の解析2023
- Author(s)
  槇島誠、梅田香織、山口凉香、山岸賢司
- Organizer
  第377回脂溶性ビタミン総合研究委員会
- Data Source
  KAKENHI-PROJECT-22K06919
[Presentation] アダマンチル基及びアルキル基導入型新規ビタミンD誘導体のユニークな生物活性2019
- Author(s)
  石澤通康、前川和樹、常盤広明、風間智彦、松本太郎、槇島誠、山田幸子
- Organizer
  日本レチノイド研究会第30回記念学術集会
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] 新規ビタミンD誘導体の細胞選択的活性及び治療効果の検討2019
- Author(s)
  石澤通康、前川和樹、常盤広明、風間智彦、松本太郎、槇島誠、山田幸子
- Organizer
  第560回日本大学医学会例会
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] ビタミンD受容体リガンドによる腸管部位選択的標的遺伝子調節2019
- Author(s)
  石澤通康、槇島誠
- Organizer
  日本ビタミン学会第71回大会
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] アダマンチル基及びアルキル基を付加した新規ビタミンD誘導体の細胞選択的活性2019
- Author(s)
  石澤通康、前川和樹、常盤広明、Antonio Mourino、風間智彦、松本太郎、槇島誠、山田幸子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] アダマンチル基及びアルキル基導入型新規ビタミンD誘導体の生物活性と骨芽細胞分化能の解析2019
- Author(s)
  石澤通康、前川和樹、常盤広明、Antonio Mourino、風間智彦、松本太郎、槇島誠、山田幸子
- Organizer
  第5回Neo Vitamin D Workshop学術集会
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] 25位アダマンチルビタミンD誘導体の構造と活性2018
- Author(s)
  石澤通康、Rocio Otero、沼本修孝、伊倉貞吉、伊藤暢聡、常盤広明、Antonio Mourino、槇島誠、山田幸子
- Organizer
  第4回Neo Vitamin D Workshop学術集会
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] 肝臓の炎症・免疫におけるビタミンD受容体の役割（コンカナバリンA誘導性肝炎モデル）2018
- Author(s)
  梅田直、梅田（遠藤）香織、中島弘幸、加藤茂明、関修司、槇島誠
- Organizer
  第361回脂溶性ビタミン総合研究委員会
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] コンカナバリンA誘導性急性肝炎マウスにおける核内受容体VDRの役割2018
- Author(s)
  梅田（遠藤）香織、梅田直、中島弘幸、加藤茂明、関修司、槇島誠
- Organizer
  日本レチノイド研究会第29回学術集会
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] 核内受容体による肝臓免疫と脂質代謝調節2018
- Author(s)
  槇島誠
- Organizer
  第32回肝類洞壁細胞研究会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] Con-A誘導性急性肝炎モデルマウスにおけるVDRの肝免疫調節作用2017
- Author(s)
  梅田（遠藤）香織, 梅田直, 中島弘幸, 関修司, 槇島誠
- Organizer
  第3回Neo Vitamin D Workshop学術集会
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] ビタミンD受容体の糞中胆汁酸代謝への関与2017
- Author(s)
  石澤通康, 槇島誠
- Organizer
  日本レチノイド研究会第28回学術集会
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] Con-A誘導性急性肝炎モデルマウスにおけるビタミンD受容体による肝免疫調節作用2016
- Author(s)
  梅田直, 梅田（遠藤）香織, 中島弘幸, 関修司, 槇島誠
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K08632
[Presentation] 共役三重結合とアダマンチル基を導入したビタミンD誘導体の生物活性及びユニークな受容体結合様式2015
- Author(s)
  石澤通康、渡會友祐、伊倉貞吉、Flavia C. M. Zacconi、Antonio Mourino、常盤広明、伊藤暢聡、山田幸子、槇島誠
- Organizer
  第1回Neo Vitamin D Workshop学術集会
- Place of Presentation
  大津プリンスホテル（滋賀県大津市）
- Year and Date
  2015-08-28
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] ビタミンDと消化管2015
- Author(s)
  槇島誠、石澤通康、西田滋
- Organizer
  第1回Neo Vitamin D Workshop学術集会
- Place of Presentation
  大津プリンスホテル（滋賀県大津市）
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] 細胞選択的及び遺伝子選択的活性を有するビタミンD誘導体の生物活性評価2014
- Author(s)
  石澤通康、高野真史、橘髙敦史、坂根里枝、須原義智、山田幸子、槇島誠
- Organizer
  第344回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京農業大学（東京都世田谷区）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] 共役diyneとアダマンチル基を側鎖に有する19-ノルビタミンD誘導体の立体選択的合成と生物活性評価2013
- Author(s)
  渡會友祐、前川和樹、石澤通康、宇野茂之、Antonio Mourino、槇島誠、常盤広明、山田幸子
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  アステールプラザ（広島県）
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] 新規VDRパーシャルアゴニストの立体選択的合成、X線結晶構造解析、および生物活性2013
- Author(s)
  前川和樹、工藤健、渡會友祐、石澤通康、内田光、中林誠、伊藤暢聡、常盤広明、槇島誠、山田幸子
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  アステールプラザ（広島県）
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] ビタミンDによる胆汁酸代謝調節.2012
- Author(s)
  槇島誠.
- Organizer
  第10回日本機能性食品医用学会総会
- Place of Presentation
  東京慈恵会医科大学(東京都)
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] Identification of PYY as vitamin D target gene in the pancreas2012
- Author(s)
  Choi Mihwa, Ozeki Jun, Kato Shigeaki, Ishihara Hisamitsu, Makishima Makoto
- Organizer
  Keystone Symposia: NuclearReceptors Matrix: Reloaded
- Place of Presentation
  British Columbia
- Data Source
  KAKENHI-PROJECT-22590295
[Presentation] Molecular and physiological basis of ligand-selective vitamin D receptor function2012
- Author(s)
  Makishima, M.
- Organizer
  The 5th International Symposium for Future Technology Creating Better Human Health and Society "Signal Transduction in Cancer and Infectious Diseases - Prevention, Diagnosis and Therapy-"
- Place of Presentation
  岡山大学(岡山)
- Year and Date
  2012-03-15
- Invited
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] 胆汁鬱滞モデルマウスにおけるビタミンD受容体の機能解析2012
- Author(s)
  石澤通康、小倉道一、加藤茂明、槇島誠
- Organizer
  日本ビタミン学会第64回大会
- Place of Presentation
  長良国際会議場(岐阜県)
- Year and Date
  2012-06-23
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] ヒト単球系細胞株におけるビタミンDによる生体異物代謝修飾2012
- Author(s)
  槇島誠、他
- Organizer
  第335回脂溶性ビタミン総合研究委員会
- Place of Presentation
  神戸学院大学(神戸)
- Year and Date
  2012-07-27
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] Zinc finger転写因子である核内受容体による代謝調節2012
- Author(s)
  槇島　誠
- Organizer
  第23回日本微量元素学会学術集会
- Place of Presentation
  砂防会館（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] 代謝調節性核内受容体におけるリガンド選択的作用発現.2012
- Author(s)
  槇島誠
- Organizer
  第17回分生研シンポジウム.アカデミア創薬?分子標的と化合物の力?
- Place of Presentation
  東京大学弥生講堂(東京都)
- Year and Date
  2012-10-29
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] Zincfinger転写因子である核内受容体による代謝調節2012
- Author(s)
  槇島誠
- Organizer
  第23回日本微量元素学会学術集会
- Place of Presentation
  砂防会館(東京都)
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] リトコール酸による腸管部位選択的なビタミンD受容体標的遺伝子転写誘導.2012
- Author(s)
  石澤通康、宇野茂之、槇島誠.
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡(福岡県)
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] ビタミンDによる胆汁酸代謝調節2012
- Author(s)
  槇島　誠
- Organizer
  第10回日本機能性食品医用学会総会
- Place of Presentation
  東京慈恵会医科大学（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] リトコール酸は腸管部位選択的にビタミンD受容体標的遺伝子の転写を誘導する.2012
- Author(s)
  石澤通康、宇野茂之、槇島誠
- Organizer
  第34回胆汁酸研究会
- Place of Presentation
  サンプラーザシーズンズ(愛知県)
- Year and Date
  2012-12-01
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] 漢方方剤繁用生薬由来レチノイン酸受容体アゴニストの探索と有用性の解析2011
- Author(s)
  田邉宏樹、小谷仁司、安井友浩、野口教好、槇島　誠、井上　誠
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-23790754
[Presentation] ビタミンD受容体欠損マウスにおける胆汁鬱滞モデルの解析2011
- Author(s)
  石澤通康、小倉道一、槇島誠、加藤茂明.
- Organizer
  第333回脂溶性ビタミン総合研究委員会
- Place of Presentation
  兵衛向陽閣(兵庫県)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] 漢方方剤繁用生薬由来レチノイン酸受容体アゴニストの探索と有用性の解析2011
- Author(s)
  田邉宏樹小谷仁司安井友浩野口教好槇島誠井上誠
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山
- Year and Date
  2011-08-27
- Data Source
  KAKENHI-PROJECT-23790754
[Presentation] 胆汁鬱滞モデルマウスにおけるビタミンD受容体の役割2011
- Author(s)
  石澤通康、小倉道一、槇島誠
- Organizer
  第33回胆汁酸研究会
- Place of Presentation
  大阪ガーデンパレス(大阪府)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] 活性型ビタミンD3及びリトコール酸によるリガンド選択的なビタミンD受容体標的遺伝子の発現誘導2010
- Author(s)
  槇島誠
- Organizer
  第329回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] 核内受容体による代謝制御と臓器連関2010
- Author(s)
  槇島誠
- Organizer
  第115回日本解剖学会総会・全国学術集会
- Place of Presentation
  盛岡
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] ビタミンD受容体蛋白質複合体のリガンド選択的ダイナミック相互作用2010
- Author(s)
  槇島誠
- Organizer
  第327回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] リガンドの代謝を介するビタミンD受容体シグナル系とダイオキシン受容体シグナル系のクロストーク2009
- Author(s)
  槇島誠
- Organizer
  第2回博多シンポジウム「内・外環境と生物応答」
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] Targeting of the vitamin D receptor, a nuclear receptor acting as an endocrine receptor and a metabolic sensor2008
- Author(s)
  Makishima M
- Organizer
  Chem-Bio informatics Society 2008 International Symposium on Pathway/Network to Disease and Drug Discovery Specially Focused on Nuclear Receptors and Metabolic Syndrome
- Place of Presentation
  東京
- Year and Date
  2008-10-22
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] Targeting of the vitamin D receptor, a nuclear receptor acting as an endocrine receptor and a metabolic sensor2008
- Author(s)
  Makishima, M.
- Organizer
  Chem-Bio Informatics Society 2008 International Symposium on Pathway/Network to Disease and Drug Discovery Specially Focused on Nuclear Receptors and Metabolic Syndrome
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] 胆汁酸センサーとして機能する核内受容体2007
- Author(s)
  槇島誠
- Organizer
  第29回胆汁酸研究会
- Place of Presentation
  つくば
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] 胆汁酸応答性核内レセプターによる生体機能調節2007
- Author(s)
  槇島誠
- Organizer
  第13回Hindgut Club Japanシンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] ビタミンD受容体欠損マウスにおける胆汁酸代謝
- Author(s)
  西田滋、石澤通康、槇島誠
- Organizer
  第35回胆汁酸研究会
- Place of Presentation
  北海道医療大学札幌サテライトキャンパス（北海道）
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] 代謝調節性核内受容体におけるリガンド選択的作用発現
- Author(s)
  槇島　誠
- Organizer
  第17回分生研シンポジウム
- Place of Presentation
  東京大学弥生講堂（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-22590294
[Presentation] VDRパーシャルアゴニスト活性を示す新規ビタミンD誘導体の合成・生物活性
- Author(s)
  渡會友祐、前川和樹、石澤通康、内田光、Flavia Zacconi、宇野茂之、常盤広明、Antonio Mourino、槇島誠、山田幸子
- Organizer
  日本レチノイド研究会第24回学術集会
- Place of Presentation
  星薬科大学百年記念館（東京都）
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] AF2構造修飾型の新規VDR選択的モジュレーターの合成と生物活性
- Author(s)
  石澤通康、渡會友祐、前川和樹、工藤健、内田光、伊藤暢聡、常盤広明、山田幸子、槇島誠
- Organizer
  第8回日本大学先端バイオフォーラム
- Place of Presentation
  日本大学会館（東京都）
- Data Source
  KAKENHI-PROJECT-25460394
[Presentation] ビタミンD受容体パーシャルアゴニストの開発と組織選択的機能発現の可能性
- Author(s)
  石澤通康、前川和樹、工藤健、中林誠、内田光、伊藤暢聡、常盤広明、山田幸子、槇島誠
- Organizer
  第524回日大医学会例会
- Place of Presentation
  日本大学医学部（東京都）
- Data Source
  KAKENHI-PROJECT-25460394

1. ISHIZAWA Michiyasu (30646542)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
2. ENDO Kaori (10445744)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. NISHIDA Shigeru (90211458)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. YAMADA Sachiko (10014078)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
5. CHOI Mihwa (30571012)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. TOMINAGA Makoto (90260041)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OKADA Yasunobu (10025661)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KOIZUMI Shuuichi (10280752)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SEKI Shuji (80531392)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. UNO Shigeyuki (90307851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
11. CHO Yoshitake (70468742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. NABEKURA Junichi (50237583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TOMITA Koichi (80314285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SAKURAI Kenichi (20366602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ISHIHARA Hisamitsu (60361086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. KOTANI Hitoshi (10594640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. INOUE Makoto (50191888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. NAGATSU Akito (70244572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TANABE Hiroki (10415606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. KOMURO Ryutaro (40403183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MAEDA Kazuhisa (60397750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HONDA Akira (10468639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 下村伊一郎 (60346145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KAWANA Katsuyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. AMANO Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
26. OGURA Michitaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. OGEKI Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. UMEDA Naoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 常盤広明

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
30. 中野祥吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MAKISHIMA Makoto 槇島 誠

槇島 誠 マキシマ マコト

愼島 誠 マキシマ マコト

Research Projects

Research Products

Co-Researchers

The role of vitamin D receptor of hepatic immune cells in the pathogenesis of nonviral liver diseasePrincipal Investigator

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Regulation of intestinal and hepatic immunity by vitamin D receptor signalingPrincipal Investigator

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The relationship between vitamin D signaling and bile acid metabolism in obesity mice.

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Regulation of intestinal and hepatic immunity and metabolism by vitamin D receptorPrincipal Investigator

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Clarify the meaning of Magnolia obovata in Kampo medicine on nuclear receptor activation.

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Regulation of inflammation and metabolism by vitamin Dreceptor in hepatic immune cellsPrincipal Investigator

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Molecular mechanism of regulation of expression and identificati on of novel target gene of vitamin D in the pancreas

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Dynamic regulation of metabolite-sensing nuclear receptorsPrincipal Investigator

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Cell sensor and its model shift

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大腸がん発症機構における脂質応答性核内レセプターの機能解析Principal Investigator

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大腸がん発症機構における脂質応答性核内レセプターの機能解析Principal Investigator

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Regulation of the expression of adipocytokines and a novel therapeutic strategy for a metabolic syndrome

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Regulation of bile acid metabolism by nuclear receptorsPrincipal Investigator

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MAKISHIMA Makoto 槇島誠

槇島誠マキシママコト

愼島誠マキシママコト