TAKABAYASHI Shuji 高林秀次

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Takabayashi Shuji 高林秀次

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Researcher Number	70372521
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Affiliation (Current)	2025: 浜松医科大学, 光医学総合研究所, 准教授
Affiliation (based on the past Project Information) *help	2025: 浜松医科大学, 光医学総合研究所, 准教授 2020 – 2024: 浜松医科大学, 光尖端医学教育研究センター, 准教授 2023: 浜松医科大学, 光医学総合研究所, 准教授 2016 – 2019: 浜松医科大学, 光尖端医学教育研究センター, 助教 2010: Hamamatsu University School of Medicine, 医学部附属動物実験施設, 助教 … More 2009 – 2010: Hamamatsu University School of Medicine, 動物実験施設, 助教 2007: Hamamatsu University School of Medicine, Experimental Animals Institute, Assistant Professor 2005 – 2006: 浜松医科大学, 動物実験施設, 助手 2004: 国立大学法人浜松医科大学, 動物実験施設, 助手 Less
Review Section/Research Field	Principal Investigator Laboratory animal science / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 42010:Animal production science-related / Laboratory animal science Except Principal Investigator Basic Section 42040:Laboratory animal science-related / Basic Section 48030:Pharmacology-related / Basic Section 57070:Developmental dentistry-related / Basic Section 55060:Emergency medicine-related / Basic Section 56040:Obstetrics and gynecology-related / Laboratory animal science
Keywords	Principal Investigator マウス / Chmpファミリー / ESCRT / Chmp2a / i-GONAD / iGONAD / 卵割 / Cnmpファミリー / Chmp4b / Chmp … More / Chmp4 / Chmp3 / Chmp2 / ESCRT-III / 筋萎縮側索硬化症 / CRISPR/CAS9 / ALS / 筋委縮性側索硬化症 / Chmp2b / ゲノム編集 / Chmp2B / Chmp2A / 筋萎縮性側索硬化症 / 遺伝子多型 / 主要組織適合遺伝子複合体(MHC) / DRB1*03 / Caja-G / MHC / Callithrix jacchus / 主要組織適合抗原遺伝子複合体 / 主要組織適合複合体(MHC) / コモンマーモセット / hobbit(hobt) / ICRマウス / 第12番染色体 / 甲状腺ペルオキシダーゼ / 矮小マウス / 甲状腺ペルオキシダーゼ(TPO) / ICR / 疾患モデルマウス / 甲状腺機能低下症 … More Except Principal Investigator ゲノム編集 / 性ホルモン / 骨格筋 / 敗血症 / 性差 / Microsatellite DNA marker / Callithrix jacchus / 血中代謝物 / HPP / モデルマウス / ALP / 低ホスファターゼ症 / リソース / 神経疾患 / ライソゾーム病 / カニクイザル / 心不全 / 敗血症性多臓器不全 / イオンチャネル / 炎症 / 性染色体 / 心筋 / 不整脈 / ICU-AW / 筋萎縮 / アデノ随伴ウイルスベクター / i-GONAD法 / モルモット / 遺伝子改変動物 / リバースジェネティクス / 冬眠動物 / 冬眠 / 生殖工学 / CRISPR/Cas9 / シリアンハムスター / Chromosomemap / Karvotvpe / Chromosome / SNP (single nucleotide polvmorphism) / MHC class II gene / Common marmoset / Simple sequence repeat / ドラフトシークエンス / Glucose phosphate isomerase / Transferrin / PCR-RFLP / ミトコンドリアDNA多型 / 高等霊長類 / 実験動物 / Microsatellite marker / DQA1遣伝子 / 染色体地図 / 核型 / 染色体 / SNP / MHC class II遺伝子 / コモンマーモセット Less

Identification of Sex-Specific Regulatory Factors in Sepsis
- Principal Investigator
  
  坂本多穂
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  International University of Health and Welfare
ESCRT-IIIを神経組織特異的に破壊するコンディショナルノックアウトの機能解析Principal Investigator
- Principal Investigator
  
  高林秀次
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Hamamatsu University School of Medicine
不妊治療の革新的な疾患モデルとなる遺伝子改変モルモットの作製
- Principal Investigator
  
  青島拓也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Hamamatsu University School of Medicine
カニクイザルにおける神経セロイドリポフスチン症モデルのリソース開発
- Principal Investigator
  
  下澤律浩
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
新規生体内ゲノム編集法による低ホスファターゼ症モデルマウス作製とその応用
- Principal Investigator
  
  齊藤陽子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Asahi University
Analysis of genetically modified mice to elucidate the function of the ESCRT complex during the cleavage stage.Principal Investigator
- Principal Investigator
  
  Takabayashi Shuji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Hamamatsu University School of Medicine
Sex differences based development of anti-sepsis drug
- Principal Investigator
  
  坂本多穂
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  University of Shizuoka
Integrating genetics and hibernation
- Principal Investigator
  
  KABASHIMA Katsuya
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kyoto University
  Hamamatsu University School of Medicine
Analysis of Amyotrophic lateral sclerosis using Chmp2A / B mutant micePrincipal Investigator
- Principal Investigator
  
  Takabayashi Shuji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Hamamatsu University School of Medicine
Estimate of the number of MHC haplotypes of a common marmosetPrincipal Investigator
- Principal Investigator
  
  TAKABAYASHI Shuji
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Hamamatsu University School of Medicine
Studies on development of genome markers and application to colonies in the common marmoset
- Principal Investigator
  
  KATOH Hideki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Hamamatsu University School of Medicine
甲状腺機能低下症を示す新規の劣性自然突然変異マウスの遺伝学的解析Principal Investigator
- Principal Investigator
  
  高林秀次
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Hamamatsu University School of Medicine

All 2023 2022 2021 2019 2018 2010 2009 2006 2005

All Journal Article Presentation

[Journal Article] Successful i-GONAD in Mice at Early Zygote Stage through In Vivo Electroporation Three Min after Intraoviductal Instillation of CRISPR-Ribonucleoprotein2022
- Author(s)
  Shuji Takabayashi, Kenta Iijima, Masumi Tsujimura, Takuya Aoshima, Hisayoshi Takagi, Kazushi Aoto and Masahiro Sato
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 23(18) Issue: 18 Pages: 10678-10678
- DOI
  10.3390/ijms231810678
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05890, KAKENHI-PROJECT-20K07243
[Journal Article] i-GONAD (improved genome-editing via oviductal nucleic acids delivery), a convenient in vivo tool to produce genome-edited rats2018
- Author(s)
  Takabayashi Shuji、Aoshima Takuya、Kabashima Katsuya、Aoto Kazushi、Ohtsuka Masato、Sato Masahiro
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 12059-12059
- DOI
  10.1038/s41598-018-30137-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08513, KAKENHI-PROJECT-18K06028, KAKENHI-PROJECT-18K11128
[Journal Article] i-GONAD: a robust method for in situ germline genome engineering using CRISPR nucleases2018
- Author(s)
  Ohtsuka Masato、Sato Masahiro、Miura Hiromi、Takabayashi Shuji、Matsuyama Makoto、Koyano Takayuki、Arifin Naomi、Nakamura Shingo、Wada Kenta、Gurumurthy Channabasavaiah B.
- Journal Title
  
  Genome Biology
  
  Volume: 19 Issue: 1 Pages: 1-15
- DOI
  10.1186/s13059-018-1400-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15063, KAKENHI-PROJECT-16H05049, KAKENHI-PROJECT-15K14371, KAKENHI-PROJECT-16K18821, KAKENHI-PROJECT-16K07087
[Journal Article] Development of microsatellite DNA markers and their chromosome assignment in the common marmoset.2009
- Author(s)
  Katoh H, Takabayashi S, Itoh T
- Journal Title
  
  Am J Primatol. 71
  
  Pages: 912-918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700446
[Journal Article] Chromosomal mapping of host resistance loci to Trichinella spiralis nematode infection in rats.2006
- Author(s)
  Suzuki T, Ishih A, Kino H, Muregi FW, Takabayashi S, Nishikawa T, Takagi H, Terada M.
- Journal Title
  
  Immunogenetics. 58(1)
  
  Pages: 26-30
- Data Source
  KAKENHI-PROJECT-16700347
[Journal Article] A mutant mouse with severe anemia and skin abnormalities controlled by a new allele of the flaky skin (fsn) locus.2005
- Author(s)
  Takabayashi S, Katoh H.
- Journal Title
  
  Exp Anim. 54(4)
  
  Pages: 339-347
- Data Source
  KAKENHI-PROJECT-16700347
[Journal Article] Microsatellite genotyping for genetic quality testing using sperm cells in the mouse.2005
- Author(s)
  Katoh H, Yoshino S, Inui Y, Honda S. Takabayashi S.
- Journal Title
  
  Exp Anim. 54(4)
  
  Pages: 373-376
- Data Source
  KAKENHI-PROJECT-16700347
[Presentation] 神経セロイドリポフスチン症２型カニクイザルに由来したiPS細胞株の樹立2023
- Author(s)
  下澤律浩、棟居佳子、飯島健太、高林秀次、八神健一、石井一弘、玉岡晃
- Organizer
  第70回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-23K05613
[Presentation] <i>i</i>-GONAD法の開始時間を変える方法2021
- Author(s)
  高林　秀次、飯島　健太、辻村　真澄、青島　拓也
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K05890
[Presentation] CRISPR-Cas9システムを用いた、老化促進モデルマウス（SAMP8）を遺伝的背景とするゲノム編集個体の作出2019
- Author(s)
  椛嶋克哉、高林秀次、青島拓也、刑部光利、北川雅敏
- Organizer
  第34回老化促進モデルマウス（SAM）学会学術大会
- Data Source
  KAKENHI-PROJECT-18K06028
[Presentation] 新規ゲノム編集技術i-GONAD法を用いた遺伝子改変ラットの作製2018
- Author(s)
  青島拓也、椛嶋克哉、佐藤正宏、大塚正人、高林秀次
- Organizer
  第65回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-18K06028
[Presentation] i-GONAD法を用いた遺伝子改変マウスにおける系統差2018
- Author(s)
  高林　秀次、青島　拓也、椛嶋　克哉、佐藤　正宏、大塚　正人
- Organizer
  第65回　日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-16K07087
[Presentation] i-GONAD法を用いた遺伝子改変マウスにおける系統差2018
- Author(s)
  高林秀次、青島拓也、椛嶋克哉、佐藤正宏、大塚正人
- Organizer
  第65回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-18K06028
[Presentation] コモンマーモセットMHCクラスIIの遺伝子型多型2010
- Author(s)
  高林秀次、田中一雄、加藤秀樹
- Organizer
  第19回日本組織適合性学会
- Place of Presentation
  東京大学(東京都)
- Year and Date
  2010-09-18
- Data Source
  KAKENHI-PROJECT-21700446
[Presentation] コモンマーモセットMHCクラスIIの遺伝子型多型2010
- Author(s)
  高林秀次、田中一雄、加藤秀樹
- Organizer
  第19回日本組織適合性学会大会
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-21700446
[Presentation] コモンマーモセットMHCクラスI遺伝子(Caja-G)の遺伝的多様性2010
- Author(s)
  河野あづみ、椎名隆、亀谷美恵、高林秀次、加藤秀樹、猪子英俊
- Organizer
  第19回日本組織適合性学会大会
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-21700446
[Presentation] コモンマーモセットMHCクラスI遺伝子(Caja-G)の遺伝的多様性2010
- Author(s)
  河野あつみ、椎名隆、亀谷美恵、高林秀次、加藤秀樹、猪子英俊
- Organizer
  第19回日本組織適合性学会
- Place of Presentation
  東京大学(東京都)
- Year and Date
  2010-09-18
- Data Source
  KAKENHI-PROJECT-21700446
[Presentation] コモンマーモセットMHC領域のゲノム構造2010
- Author(s)
  河野あづみ、亀谷美恵、高林秀次、加藤秀樹、猪子英俊、椎名隆
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-21700446
[Presentation] MHC遺伝子多型を用いた系統育成の試み2009
- Author(s)
  高林秀次
- Organizer
  第一回マーセット会議
- Place of Presentation
  順天堂大学
- Year and Date
  2009-03-02
- Data Source
  KAKENHI-PROJECT-21700446
[Presentation] コモンマーモセットにおけるミトコンドリアDNA D-loop領域のRFLP2006
- Author(s)
  高林秀次
- Organizer
  第53回日本実験動物学会総会
- Place of Presentation
  神戸
- Year and Date
  2006-05-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300134
[Presentation] RFLPs of the D-loop of mitochondrial chromosome in the common marmoset2006
- Author(s)
  Takabayashi, S
- Organizer
  53rd Annual Meeting of the Japanese Association for Laboratory Animal Science
- Place of Presentation
  Kobe
- Year and Date
  2006-05-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300134
[Presentation] コモンマーモセットのマイクロサテライトマーカーの開発2005
- Author(s)
  高林秀次
- Organizer
  第52回日本実験動物学会総会
- Place of Presentation
  東京
- Year and Date
  2005-12-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300134
[Presentation] Development of microsatellite DNA markers in the common marmoset2005
- Author(s)
  Takabayashi, S
- Organizer
  52nd Annual Meeting of the Japanese Association for Laboratory Animal Science
- Place of Presentation
  Tokyo
- Year and Date
  2005-05-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300134

1. 坂本多穂 (80433150)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 黒川洵子 (40396982)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 松田直之 (50332466)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 青戸一司 (60360476)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. KATOH Hideki (30142053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NISHIKAWA Tetsu (50260584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TANIOKA Yoshikuni (10072406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUEMIZU Hiroshi (40332209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KABASHIMA Katsuya (30615422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 青島拓也 (80815283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 飯島健太 (20565626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 永森收志 (90467572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 下澤律浩 (50300786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 揚山直英 (50399458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 齊藤陽子 (30404487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 齊藤一誠 (90404540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 佐藤正宏 (30287099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 野口洋文 (50378733)

# of Collaborated Projects: 1 results

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19. 水野初 (30457288)

# of Collaborated Projects: 1 results

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20. NAKAMURA Shingo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKABAYASHI Shuji 高林 秀次

Takabayashi Shuji 高林 秀次

Research Projects

Research Products

Co-Researchers

Identification of Sex-Specific Regulatory Factors in Sepsis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ESCRT-IIIを神経組織特異的に破壊するコンディショナルノックアウトの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

不妊治療の革新的な疾患モデルとなる遺伝子改変モルモットの作製

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

カニクイザルにおける神経セロイドリポフスチン症モデルのリソース開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規生体内ゲノム編集法による低ホスファターゼ症モデルマウス作製とその応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of genetically modified mice to elucidate the function of the ESCRT complex during the cleavage stage.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Sex differences based development of anti-sepsis drug

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrating genetics and hibernation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Amyotrophic lateral sclerosis using Chmp2A / B mutant micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Estimate of the number of MHC haplotypes of a common marmosetPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on development of genome markers and application to colonies in the common marmoset

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

甲状腺機能低下症を示す新規の劣性自然突然変異マウスの遺伝学的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Successful i-GONAD in Mice at Early Zygote Stage through In Vivo Electroporation Three Min after Intraoviductal Instillation of CRISPR-Ribonucleoprotein2022

Author(s)

Journal Title

TAKABAYASHI Shuji 高林秀次

Takabayashi Shuji 高林秀次

[Presentation] CRISPR-Cas9システムを用いた、老化促進モデルマウス（SAMP8）を遺伝的背景とするゲノム編集個体の作出2019