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OKADA Tetsuya  岡田 徹也

ORCIDConnect your ORCID iD *help
Researcher Number 70378529
Other IDs
Affiliation (based on the past Project Information) *help 2023: 京都大学, 理学研究科, 助教
2016 – 2020: 京都大学, 理学研究科, 助教
2015 – 2016: 京都大学, 大学院理学研究科, 助教
2012 – 2015: 京都大学, 理学(系)研究科(研究院), 助教
2011: 京都大学, 医学研究科, 助教 … More
2010: 京都大学, 理学研究科, 助教
2007 – 2010: Kyoto University, 大学院・理学研究科, 助教
2006: 京都大学, 大学院理学研究科, 助手
2005: 京都大学, 大学院・理学研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Cell biology / Basic Section 43030:Functional biochemistry-related / Functional biochemistry
Except Principal Investigator
Cell biology / Risk sciences of radiation/Chemicals
Keywords
Principal Investigator
小胞体 / 小胞体ストレス / 糖鎖 / 小胞体関連分解 / マンノシダーゼ / タンパク質分解 / 小胞輸送 / タンパク分解 / マンノース / 転写誘導 … More / DT40 / ATF6 / ストレス応答 / プロテオリシス / 酸化還元 … More
Except Principal Investigator
エスコートタンパク質 / 膜結合性転写因子 / 小胞輸送 / 小胞体ストレス / 細部内情報伝達 / 進化 / エスコート / ゴルジ体 / 小胞体関連分解 / 分子シャペロン / 転写因子 / 小胞体 / タンパク質品質管理 / DT40細胞 / データマイニング / 情報学 / はいスループットスクリーニング / 小核試験 / レギュラトリーサイエンス / ハイスループットスクリーニング / 小核実験 / 変異原 / 発がん物質 / 遺伝毒物学 / 化審法 / 有害化学物質 Less
  • Research Projects

    (8 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (14 People)
  •  小胞体関連分解による細胞内代謝制御の包括的解析Principal Investigator

    • Principal Investigator
      岡田 徹也
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      Kyoto University
  •  Regulation of ER-localized mannosidase EDEM2 via the intermolecular disulfide bondPrincipal Investigator

    • Principal Investigator
      Okada Tetsuya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      Kyoto University
  •  Substrate recognition mechanism of the endoplasmic reticulum-localized mannosidase EDEMPrincipal Investigator

    • Principal Investigator
      Okada Tetsuya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Kyoto University
  •  Elucidation of regulation mechanism of the endoplasmic reticulum membrane-bound transcription factor ATF6 and its role in the evolution of vertebrates

    • Principal Investigator
      Mori Kazutoshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cell biology
    • Research Institution
      Kyoto University
  •  Establishment of high-throughput screening of toxic chemical compounds.

    • Principal Investigator
      Takeda Shunichi
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Kyoto University
  •  The activation mechanism of a membrane-bound transcription factor ATF6 in response to Endoplasmic Reticulum StressPrincipal Investigator

    • Principal Investigator
      OKADA Tetsuya
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cell biology
    • Research Institution
      Kyoto University
  •  Mechanism for the specific activation of a membrane-bound transcription factor ATF6 by Endoplasmic Reticulum StressPrincipal Investigator

    • Principal Investigator
      OKADA Tetsuya
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cell biology
    • Research Institution
      Kyoto University
  •  小胞体膜結合性転写因子ATF6の活性化に関与する小胞輸送の分子機構解析Principal Investigator

    • Principal Investigator
      岡田 徹也
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cell biology
    • Research Institution
      Kyoto University

All 2020 2018 2017 2016 2015 2014 2013 2012 2011 2010 2008 2007

All Journal Article Presentation

  • [Journal Article] EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD2020

    • Author(s)
      George Ginto、Ninagawa Satoshi、Yagi Hirokazu、Saito Taiki、Ishikawa Tokiro、Sakuma Tetsushi、Yamamoto Takashi、Imami Koshi、Ishihama Yasushi、Kato Koichi、Okada Tetsuya、Mori Kazutoshi
    • Journal Title

      eLife

      Volume: 9

    • DOI

      10.7554/elife.53455

    • NAID

      120006817590

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06110, KAKENHI-PROJECT-19K06658, KAKENHI-PROJECT-19K16111, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-18K06216, KAKENHI-PLANNED-17H06414
  • [Journal Article] 特集 細胞高次機能をつかさどるオルガネラコミュニケーション Ⅰ.小胞体 小胞体に存在する複数のオルガネラ・ゾーン2018

    • Author(s)
      森 和俊、岡田 徹也
    • Journal Title

      生体の科学

      Volume: 69 Issue: 6 Pages: 527-531

    • DOI

      10.11477/mf.2425200913

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2018-12-15
    • Data Source
      KAKENHI-PROJECT-18K06110
  • [Journal Article] SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation2017

    • Author(s)
      Takehiro Sugimoto, Satoshi Ninagawa, Shimpei Yamano, Tokiro Ishikawa, Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori
    • Journal Title

      Cell Struct. Funct.

      Volume: 42 Issue: 2 Pages: 81-94

    • DOI

      10.1247/csf.17007

    • NAID

      130005708193

    • ISSN
      0386-7196, 1347-3700
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15116, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-15K06996, KAKENHI-PROJECT-16K18538
  • [Journal Article] Mannose trimming mechanism in endoplasmic reticulum-associated degradation of glycoproteins2016

    • Author(s)
      岡田徹也、蜷川暁、森和俊
    • Journal Title

      生化学

      Volume: 88 Issue: 2 Pages: 257-260

    • DOI

      10.14952/SEIKAGAKU.2016.880257

    • NAID

      40020843457

    • ISSN
      0037-1017
    • Year and Date
      2016-04-25
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06996
  • [Journal Article] Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway.2015

    • Author(s)
      Ninagawa S, Okada T, Sumitomo Y, Horimoto S, Sugimoto T, Ishikawa T, Takeda S, Yamamoto T, Suzuki T, Kamiya Y, Kato K, Mori K.
    • Journal Title

      The Journal of Cellular Biology

      Volume: 211 Issue: 4 Pages: 775-784

    • DOI

      10.1083/jcb.201504109

    • NAID

      120005672576

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06996, KAKENHI-PROJECT-15K18529, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PUBLICLY-26110725, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-26840065, KAKENHI-PROJECT-26291040
  • [Journal Article] EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.2014

    • Author(s)
      Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S, Ishikawa T, Takeda S, Sakuma T, Yamamoto T, Mori K
    • Journal Title

      J Cell Biol.

      Volume: 206 Issue: 3 Pages: 347-356

    • DOI

      10.1083/jcb.201404075

    • NAID

      120005468381

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-24249002, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26840065
  • [Journal Article] Genetics of rheumatoid arthritis contributes to biology and drug discovery.2014

    • Author(s)
      Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, (省略), GARNET consortium, (以下省略).
    • Journal Title

      Nature

      Volume: 506 Issue: 7488 Pages: 376-381

    • DOI

      10.1038/nature12873

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22133008, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390360, KAKENHI-PROJECT-24592285, KAKENHI-PROJECT-25293225, KAKENHI-PROJECT-26460649, KAKENHI-PROJECT-221S0001
  • [Journal Article] The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein.2013

    • Author(s)
      Horimoto S, Ninagawa S, Okada T, Koba H, Sugimoto T, Kamiya Y, Kato K, Takeda S, Mori K
    • Journal Title

      J Biol Chem.

      Volume: 288 Issue: 44 Pages: 31517-31527

    • DOI

      10.1074/jbc.m113.476010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-24249002, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008
  • [Journal Article] The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination.2013

    • Author(s)
      Saito Y, Takeda J, Okada M, Kobayashi J, Kato A, Hirota K, Taoka M, Matsumoto T, Komatsu K, Isobe T.
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 2022-2022

    • DOI

      10.1038/srep02022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23241021, KAKENHI-PUBLICLY-24114509, KAKENHI-PUBLICLY-25112513, KAKENHI-PROJECT-25281021, KAKENHI-PROJECT-25550025, KAKENHI-PROJECT-25550026
  • [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012

    • Author(s)
      岡田随象
    • Journal Title

      PLoS Genetics

      Volume: (掲載確定) Issue: 1 Pages: 1002455-1002455

    • DOI

      10.1371/journal.pgen.1002455

    • NAID

      120005906866

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J00226, KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-20689029, KAKENHI-PROJECT-21390299, KAKENHI-PROJECT-21591258, KAKENHI-PROJECT-21591277, KAKENHI-PLANNED-22021023, KAKENHI-PLANNED-22116010, KAKENHI-PROJECT-22591074, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23590379, KAKENHI-PROJECT-23689051, KAKENHI-PROJECT-24591436
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: (in press) Issue: 5 Pages: 511-6

    • DOI

      10.1038/ng.2231

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-20689029, KAKENHI-PROJECT-21591264, KAKENHI-PLANNED-22133008, KAKENHI-PROJECT-22710191, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23689051, KAKENHI-PROJECT-24390360, KAKENHI-PROJECT-24591679, KAKENHI-PROJECT-24592285, KAKENHI-PROJECT-24659274, KAKENHI-PROJECT-221S0002, KAKENHI-PLANNED-22116010, KAKENHI-ORGANIZER-22133001
  • [Journal Article] SEL1L Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Luminal Proteins but not Transmembrane Proteins in Chicken DT40 Cell Line2011

    • Author(s)
      S. Ninagawa, T. Okada, S. Takeda and K. Mori
    • Journal Title

      Cell Struct. Funct.

      Volume: 36 Issue: 2 Pages: 187-195

    • DOI

      10.1247/csf.11018

    • NAID

      130004137570

    • ISSN
      0386-7196, 1347-3700
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19058009, KAKENHI-PROJECT-23221005
  • [Journal Article] Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus2011

    • Author(s)
      Yoshimi Sato, Satomi Nadanaka, Tetsuya Okada, Katsuya Okawa, Kazutoshi Mori
    • Journal Title

      Cell Structure and Function 36

      Pages: 35-47

    • NAID

      40019163862

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770205
  • [Journal Article] ATF6 is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum2008

    • Author(s)
      Yusuke adachi, Keisuke Yamamoto, Tetsuya Okada, Hiderou Yoshida, Akihiko Harada, Kazutoshi Mori
    • Journal Title

      Cell Structure and Function 133

      Pages: 75-89

    • NAID

      40016794073

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19770170
  • [Journal Article] Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress2007

    • Author(s)
      Satomi Nadanaka, Tetsuya Okada, Hiderou Yoshida, Kazutoshi Mori
    • Journal Title

      Molecular and Cellular Biology Vol.27・No.3

      Pages: 1027-1043

    • Data Source
      KAKENHI-PROJECT-17770158
  • [Presentation] A Role of a Thioredoxin Protein on EDEM2 Mannosidase Activity2018

    • Author(s)
      Ginto George, Satoshi Ninagawa, Tokiro Ishikawa, Tetsuya Okada, Kazutoshi Mori
    • Organizer
      The 91st Annual Meeting of the Japanese Biochemical Society
    • Data Source
      KAKENHI-PROJECT-18K06110
  • [Presentation] Analysis of the unfolded protein resuponse using chicken DT40 cell line2010

    • Author(s)
      Tetauya Okada
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-21770205
  • [Presentation] Analysis of mechanism of ATF6 activation in response to ER stress2010

    • Author(s)
      Yoshimi Sato, Satomi Nadanaka, Tetsuya Okada, Kazutoshi Mori
    • Organizer
      FASEB Summer Research Conference
    • Place of Presentation
      Saxtns River, Vermont Academy
    • Year and Date
      2010-07-28
    • Data Source
      KAKENHI-PROJECT-21770205
  • [Presentation] The unfolded protein response in chicken DT40 cells : A novel tool for comprehensive genetic analysis mammalian-type unfolded protein response2010

    • Author(s)
      Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori
    • Organizer
      FASEB Summer Research Conference
    • Place of Presentation
      Saxtns River, Vermont Academy
    • Year and Date
      2010-07-28
    • Data Source
      KAKENHI-PROJECT-21770205
  • [Presentation] Analysis of the unfolded protein response using chicken DT40 cell line2010

    • Author(s)
      Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-21770205
  • [Presentation] The unfolded protein response in chicken DT40 cells : A novel tool fox comprehensive genetic analysis mammalian-type unfolded protein response2010

    • Author(s)
      Tetsuya Okada
    • Organizer
      FASEB Summer Research Conference
    • Place of Presentation
      Saxtona River, Vermont Aademy(アメリカ)
    • Year and Date
      2010-07-28
    • Data Source
      KAKENHI-PROJECT-21770205
  • 1.  Takeda Shunichi (60188191)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 2.  SHIMIZU Hiroyasu (60340551)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  HIROTA Kouji (00342840)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  YAMADA Ryo (50301106)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  SASANUMA Hiroyuki (00531691)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  TAKAHASHI Ryosuke (90216771)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Mori Kazutoshi (70182194)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  ISHIKAWA Tokiro (70632545)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  YAMAMOTO Takashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KATO Koichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  NINAGAWA Satoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  岡田 随象
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 13.  石井 直人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  山本 一彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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