AOKI Manabu 青木学

… Alternative Names

青木学アオキマナブ

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Researcher Number	70389542
Other IDs
Affiliation (Current)	2025: 熊本保健科学大学, 保健科学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 熊本保健科学大学, 保健科学部, 教授 2012 – 2014: 熊本保健科学大学, 保健科学部, 講師 2009 – 2010: Kumamoto Health Science University, 保健科学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine / Applied pharmacology Except Principal Investigator Basic Section 54030:Infectious disease medicine-related
Keywords	Principal Investigator プロテアーゼ阻害剤 / 薬剤耐性 / HIV-1 / HIV / インテグラーゼ阻害剤 Except Principal Investigator 薬剤耐性 / メインプロテアーゼ(Mpro)阻害剤 / SARS-CoV-2 / インテグラーゼ阻害剤 / HIV-1

ハロゲン修飾を介したブースター不要抗COVID-19治療薬のデザイン・合成と臨床開発
- Principal Investigator
  
  満屋裕明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Center for Global Health and Medicine
HIVプロテアーゼ(PR)阻害剤によるHIVPR/Integrase 2重阻害メカニズムの解明Principal Investigator
- Principal Investigator
  
  青木学
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto Health Science University
Study of mechanism of HIV resistance to integrase strand transfer inhibitors (INSTI) aiming at development of INSTI-resistance-repellant therapeutics
- Principal Investigator
  
  MITSUYA Hiroaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Center for Global Health and Medicine
Elucidation of TPV's protease dimerization inhibition (PDI) mechanism and development of potent compounds possessing PDI activityPrincipal Investigator
- Principal Investigator
  
  AOKI Manabu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto Health Science University
Role of HIV Gag mutations in acquisition of resistance to protease inhibitors.Principal Investigator
- Principal Investigator
  
  青木学
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto Health Science University

All 2023 2022 2014 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants2023
- Author(s)
  Aoki M, Aoki-Ogata H, Bulut H, Hayashi H, Takamune N, Kishimoto N, Tanaka H, Higashi-Kuwata N, Hattori S, Das D, Rao KV, Iwama K, Davis DA, Hasegawa K, Murayama K, Yarchoan R, Ghosh AK, Pau AK, Machida S, Misumi S, and Hiroaki Mitsuya H.
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 28 Pages: 1-15
- DOI
  10.1126/sciadv.adg2955
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07918, KAKENHI-PROJECT-23K07956
[Journal Article] Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.2014
- Author(s)
  Hayashi H, Takamune N, Nirasawa T, Aoki M, Morishita Y, Das D, Koh Y, Ghosh AK, Misumi S, Mitsuya H.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A.
  
  Volume: 111 Issue: 33 Pages: 12234-9
- DOI
  10.1073/pnas.1400027111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590161, KAKENHI-PROJECT-24791031, KAKENHI-PROJECT-26293239
[Journal Article] Conserved hydrogen-bonding network of P2 bis-tetrahydrofuran containing HIV-1 protease inhibitors (PI) with protease active site amino acid-backbone aid in their activity against PI-resistant HIV.2014
- Author(s)
  Yedidi RS, Garimella H, Aoki M, Aoki H, Desai DV, Chang SB, Davis DA, Fyvie WS, Kaufman JD, Smith DW, Das D, Wingfield PT, Maeda K, Ghosh AK and Mitsuya H.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 58 Issue: 7 Pages: 3679-88
- DOI
  10.1128/aac.00107-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791031, KAKENHI-PROJECT-26293239
[Journal Article] P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety.2013
- Author(s)
  Yedidi RS, Maeda K, Fyvie WS, Steffey M, Davis DA, Palmer I, Aoki M, Kaufman JD, Stahl SJ, Garimella H, Das D, Wingfield PT, Ghosh AK, Mitsuya H.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 57 Issue: 10 Pages: 4920-4927
- DOI
  10.1128/aac.00868-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791031
[Journal Article] Delayed emergence of HIV-1 variants resistant to 4’-ethynyl-2-fluoro-2’-deoxyadenosine: comparative sequential passage study with lamivudine, tenofovir, emtricitabine and BMS-9860012013
- Author(s)
  Kenji Maeda, Darshan V Desai, Manabu Aoki, Hirotomo Nakata, Eiichi N Kodama, Hiroaki Mitsuya
- Journal Title
  
  Antiviral Therapy
  
  Volume: 19 Issue: 2 Pages: 179-189
- DOI
  10.3851/imp2697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390254, KAKENHI-PROJECT-24791031, KAKENHI-PROJECT-25670255, KAKENHI-PROJECT-26461510
[Journal Article] GRL-0519, a Novel Oxatricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro, Antimicrob2013
- Author(s)
  Amano M, Tojo Y, Gomez PMS, Campbell JR, Das D, Aoki M, Xu CX, Rao KV, Ghosh AK, and Mitsuya H
- Journal Title
  
  Agents Chemother
  
  Volume: 57 Issue: 5 Pages: 2036-2046
- DOI
  10.1128/aac.02189-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-23791140, KAKENHI-PROJECT-24659484, KAKENHI-PROJECT-24791031
[Journal Article] Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV- 12012
- Author(s)
  Manabu Aoki, Matthew L. Danish, Hiromi Aoki- Ogata, Masayuki Amano, Kazuhiko Ide, Debananda Das, Yasuhiro Koh, and Hiroaki Mitsuya
- Journal Title
  
  Journal of Virology
  
  Volume: 86 Issue: 24 Pages: 13384-13396
- DOI
  10.1128/jvi.07234-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-23791140, KAKENHI-PROJECT-24659484, KAKENHI-PROJECT-24791031
[Journal Article] Novel HIV-1 protease inhibitors (PIs)containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants.2011
- Author(s)
  Ide K, Aoki M, Amano M, Koh Y, Yedidi RS, Das D, Leschenko S, Chapsal B, Ghosh AK, Mitsuya H.
- Journal Title
  
  Antimicrob. Agents Chemother. 55
  
  Pages: 1717-1727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790527
[Journal Article] Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro.2010
- Author(s)
  Tojo Y, Koh Y, Amano M, Aoki M, Das D, Kulkarni S, Anderson DD, Ghosh AK, Mitsuya H.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: Vol.54 Pages: 3460-3470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790527
[Journal Article] Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors.2010
- Author(s)
  Ghosh AK, Xu CX, Rao KV, Baldridge A, Agniswamy J, Wang YF, Weber IT, Aoki M, Miguel SG, Amano M, Mitsuya H.
- Journal Title
  
  ChemMedChem. 8
  
  Pages: 1850-1854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790527
[Journal Article] Novel Protease Inhibitors(PIs)Containing Macrocyclic Components and 3(R),3a(S),6a(R)-bis-Tetrahydrofuranylurethane(bis-THF) That Are Potent Against Multi-PI-Resistant HIV-1 Variants In Vitro.2010
- Author(s)
  Tojo Y, Koh Y, Amano M, Aoki M, Das D, Ghosh AK, Mitsuya H.
- Journal Title
  
  Antimicrob. Agents Chemother. 54
  
  Pages: 3460-3470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790527
[Journal Article] Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors.2010
- Author(s)
  Ghosh AK, Xu CX, Rao KV, Baldridge A, Agniswamy J, Wang YF, Weber IT, Aoki M, Miguel SG, Amano M, Mitsuya H.
- Journal Title
  
  ChemMedChem
  
  Volume: Vol.8 Pages: 1850-1854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790527
[Journal Article] Non-cleavage site Gag mutations in amprenavir-resistant HIV-1 Predispose HIV-1 to rapid acquisition of amprenaive resistance but delays development of resistance to other protease inhibitors.2009
- Author(s)
  Aoki M, Venzon DJ, Koh Y, Aoki-Ogata H, Miyakawa T, Yoshimura K, Maeda K, Mitsuya H.
- Journal Title
  
  J.Virol. 83
  
  Pages: 3059-3068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790527
[Journal Article] Non-cleavage site Gag mutations in amprenavir-resistant HIV-1 predispose HIV-1 to rapid acquisition of amprenavir resistance but delays development of resistance to other protease inhibitors2009
- Author(s)
  Manabu Aoki
- Journal Title
  
  Journal of Virology Vol.83
  
  Pages: 3059-3068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] HIV-1の核移行を阻害するHIV-1プロテアーゼ阻害剤の開発2023
- Author(s)
  青木学, 青木宏美, Haydar Bulut, 林宏典, 長谷川和也, 高宗暢暁, 岸本直樹, 田中大貴, Arun K. Ghosh, 町田晋一, 三隅将吾, 満屋裕明
- Organizer
  第31回日本抗ウイルス療法学会
- Data Source
  KAKENHI-PROJECT-23K07956
[Presentation] GRL-142 Binds to and Impairs HIV-1-Integrase-Nuclear Localization Signal and Exerts Potent Activity against INSTI-Resistant HIV-12023
- Author(s)
  Manabu Aoki, Hiromi Aoki-Ogata, Haydar Bulut, Hironori Hayashi, Arun K. Ghosh, Alice K. Pau, and Hiroaki Mitsuya
- Organizer
  24th Kumamoto AIDS Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07956
[Presentation] GRL142 Binds to and Impairs HIV-1-Integrase-Nuclear Localizing Signal and Exerts Potent Activity against INSTI-Resistant HIV-12022
- Author(s)
  Manabu Aoki1, Hiromi Aoki-Ogata, Haydar Bulut1, Hironori Hayashi, Arun K. Ghosh, Alice K. Pau, and Hiroaki Mitsuya
- Organizer
  HIV DART 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03727
[Presentation] 新規プロテアーゼ阻害剤GRL-142は、インテグラーゼのNLSに結合、HIV-1DNAの核移行を阻害し、インテグラーゼ阻害剤耐性HIV-1変異体を強力に阻害する2022
- Author(s)
  青木学, 青木宏美, Haydar Bulut, 林宏典, 長谷川和也, Arun K Ghosh, Alice K. Pau, 満屋裕明
- Organizer
  第36回日本エイズ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-20H03727
[Presentation] HIV-1プロテアーゼ阻害剤GRL-142は、インテグラーゼのNLSに結合、HIV-1DNAの核移行を阻害し、インテグラーゼ阻害剤耐性HIV-1変異体を強力に阻害する2022
- Author(s)
  青木学, 青木宏美, Haydar Bulut, 林宏典, 長谷川和也, Arun K Ghosh, Alice K. Pau, 満屋裕明
- Organizer
  第30回日本抗ウイルス療法学会
- Data Source
  KAKENHI-PROJECT-20H03727
[Presentation] Tipranavir (TPV)-resistant HIV-1 lacks both protease enzymatic inhibition and dimerization inhibition activity.2011
- Author(s)
  M.Aoki, K.Ide, M.L.Danish, Y.Koh, H.Mitsuya.
- Organizer
  18th Conference on Retroviruses and Opportunistic Infections.
- Place of Presentation
  Boston, MA, USA.
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] Tipranaivr (TPV)-resistant HIV-1 lacks both protease enzvmatic inhibition and dimerization inhibition activity.2011
- Author(s)
  M.Aoki, K.Ide, M.L.Danish, Y.Koh, H.Mitsuya.
- Organizer
  18th Conference on retroviruses and opportunistic infections
- Place of Presentation
  Hynes convention center (Boston, MA, US)
- Year and Date
  2011-03-02
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] Novel HIV-1 protease inhibitors () containing bis-tetrahydrofuran (bis-THF) and a novel polycyclic ligand.2010
- Author(s)
  K.Ide, M.Aoki, Y.Koh, M.Amano, D.D.Anderson, B.Chapsal, A.K.Ghosh, H.Mitsuya.
- Organizer
  XVIII International AIDS Conference.
- Place of Presentation
  Vienna, Austria.
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] Early phase dynamics of HIV-1 infection in hPBM-transplanted NOD/SCID/Jak3-/-mice using infectious HIV-1 carrying fluorescent protein mCherry.2010
- Author(s)
  N.Higash-Kuwata, H.Aoki-Ogata, S.Hattori, T.Nakamura, M.Aoki, S.Okada, H.Mitsuya.
- Organizer
  XVIII International AIDS Conference.
- Place of Presentation
  Vienna, Austria.
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] Tipranavir 耐性HIVはプロテアーゼ二量体化阻止能と酵素活性阻止能の双方を喪失している2010
- Author(s)
  青木学、井手一彦、M.L.Danish、満屋裕明
- Organizer
  第20回抗ウイルス療法研究会学術集会
- Place of Presentation
  熊本県
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] The Binary Protease Inhibitor, Darunavir, Has a High Genetic Barrier to the Emergence of Resistant HIV-1 Variants.2010
- Author(s)
  Yasuhiro Koh, M Aoki, M Amano, H Ogata-Aoki, S Leschenko-Yashchuk, A Ghosh, H Mitsuya.
- Organizer
  17th Conference on Retroviruses and Opportunistic Infections.
- Place of Presentation
  San Francisco, CA, USA.
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] Tipranavir 耐性HIV はプロテアーゼ二量体化阻止能と酵素活性阻止能の双方を喪失している2010
- Author(s)
  青木学、井手一彦、M.L.Danish、満屋裕明
- Organizer
  第24回日本エイズ学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] Tipranavir耐性HIVはtipranavirのプロテアーゼ二量体化阻止能と酵素活性阻止能の双方に抵抗する2010
- Author(s)
  青木学、井手一彦、M.L.Danish、満屋裕明
- Organizer
  第24回日本エイズ学会学術集会・総会
- Place of Presentation
  グランドプリンスホテル高輪(東京都)
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] The binary mechanism of HIV-1 resistance to tipranaivr(TPV) : Loss of inhibition of pretease catalytic activity and protease dimerization2009
- Author(s)
  青木学
- Organizer
  49th Interscience conference on antimicrobial agents and chemotherapy
- Place of Presentation
  The moscone center(San Francisco, CA, US)
- Year and Date
  2009-09-13
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] 複数のプロテアーゼ阻害剤耐性臨床分離株を用いて誘導したtipranavir 耐性HIV 変異体の解析2009
- Author(s)
  青木学、こう康博、天野将之、東條靖、満屋裕明
- Organizer
  第23回日本エイズ学会学術集会
- Place of Presentation
  愛知県
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] 複数のプロテアーゼ阻害剤耐性臨床HIV分離株を用いて誘導した tipranavir 高度耐性変異株の解析2009
- Author(s)
  青木学
- Organizer
  第23回日本エイズ学会学術集会・総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-21790527
[Presentation] The binary mechanism of HIV-1 resistance to tipranavie (TPV) : Loss of inhibition of protease catalytic activity and protease dimerization.2009
- Author(s)
  M.Aoki, Y.Koh, K.Ide, M.L.Danish, H.Aoki-Ogata, H.Mitsuya.
- Organizer
  49th Interscience conference on antimicrobial agents and chemotherapy.
- Place of Presentation
  San Francisco, CA, USA.
- Data Source
  KAKENHI-PROJECT-21790527

1. MITSUYA Hiroaki (20136724)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 児玉栄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. GHOSH Arun K.

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 高宗暢暁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 林宏典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AOKI Manabu 青木 学

青木 学 アオキ マナブ

Research Projects

Research Products

Co-Researchers

ハロゲン修飾を介したブースター不要抗COVID-19治療薬のデザイン・合成と臨床開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

HIVプロテアーゼ(PR)阻害剤によるHIVPR/Integrase 2重阻害メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of mechanism of HIV resistance to integrase strand transfer inhibitors (INSTI) aiming at development of INSTI-resistance-repellant therapeutics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of TPV's protease dimerization inhibition (PDI) mechanism and development of potent compounds possessing PDI activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of HIV Gag mutations in acquisition of resistance to protease inhibitors.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conserved hydrogen-bonding network of P2 bis-tetrahydrofuran containing HIV-1 protease inhibitors (PI) with protease active site amino acid-backbone aid in their activity against PI-resistant HIV.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Delayed emergence of HIV-1 variants resistant to 4’-ethynyl-2-fluoro-2’-deoxyadenosine: comparative sequential passage study with lamivudine, tenofovir, emtricitabine and BMS-9860012013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GRL-0519, a Novel Oxatricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro, Antimicrob2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV- 12012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel HIV-1 protease inhibitors (PIs)containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants.2011

Author(s)

Journal Title

Data Source

[Journal Article] Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro.2010

Author(s)

Journal Title

Data Source

[Journal Article] Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors.2010

Author(s)

AOKI Manabu 青木学

青木学アオキマナブ