KUBO Tadahiko 久保忠彦

Researcher Number	70397959
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2021: 広島大学, 医系科学研究科(医), 准教授 2017 – 2018: 広島大学, 医歯薬保健学研究科(医), 准教授 2016: 広島大学, 医歯薬保健学研究院(医), 准教授 2015: 広島大学, 大学院医歯薬保健学研究院(医), 准教授 2014: 広島大学, 病院, 講師 … More 2013 – 2014: 広島大学, 大学病院, 講師 2012: 広島大学, 病院(医), 講師 2008 – 2011: 広島大学, 病院, 講師 2007: Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor 2006: 広島大学, 大学院医歯薬学総合研究科, 助手 2005: Hiroshima University, Graduate School of Biomedical Sciences, Assistant, 大学院・医歯薬学総合研究科, 助手 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery Except Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator 腫瘍溶解性ウイルス / 骨肉腫 / 癌 / microRNA / マイクロＲＮＡ / 悪性腫瘍 / 腫瘍溶解ウイルス / マイクロRNA / Isolated limb perfusion / oncolytic virus … More / vesicular stomatitis virus / Sarcoma / リポソーム / ウイルス治療 / 近赤外線蛍光蛋白 / 蛍光イメージング / ビスフォスフォネート / 転移性骨腫瘍 … More Except Principal Investigator 骨肉腫 / PET / エクソソーム / 癌 / ホーミング / MSC / homing / homing機能 / デリバリーシステム / MSC由来エクソソーム / Liposome / cancer / リポソーム / Ewing's sarcoma / Chondrosarcoma / Osteosarcoma / Bisphosphonate / 腫瘍細胞浸潤抑制 / 細胞周期 / アポトーシス / ビスフォスフォネート / テロメア / テロメラーゼ阻害剤 / 転移 / microRNA / 磁性体リポソーム / 骨再生 / 細胞増殖因子 / 人工骨 / 多血小板血漿 / 磁性体リボソーム / 遺伝子 Less

Development of a novel delivery system and osteosarcoma therapy using down-regulated MSC-derived exosomes
- Principal Investigator
  
  Furuta Taisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
Multimodal therapy by microRNA-encoding oncolytic virusPrincipal Investigator
- Principal Investigator
  
  Kubo Tadahiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Fluorescent tumor cell detection by tumor-specific virus VSV for precise osteosarcoma resectionPrincipal Investigator
- Principal Investigator
  
  KUBO Tadahiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Novel Medical therapy using Telomerase Inhibitor TMPyP4 for Osteosarcoma
- Principal Investigator
  
  FUJIMORI Jun
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Exosome-formed miRNA for the treatment of osteosarcoma
- Principal Investigator
  
  SHIMOSE Shoji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Magnetic targeting therapy with new bisphosphonates for the treatment of bone metastasisPrincipal Investigator
- Principal Investigator
  
  KUBO Tadahiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Target therapy in bone and soft tissue sarcomas using magnetic liposomal telomerase inhibitor under an external magnetic force
- Principal Investigator
  
  MATSUO Toshihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Targeted delivery of magnetic Iiposome encapsulated platelet rich plasma for bone formation in a rat bone-defect model
- Principal Investigator
  
  SHIMOSE Shouji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Isolated limb perfusion for vesicular stomatitis virus delivery in sarcoma-bearing ratsPrincipal Investigator
- Principal Investigator
  
  KUBO Tadahiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Anticancer therapy with liposomes combined with fluorodeoxyglucose (FDG) using as a tumor detection agent in position emission tomography (PET)
- Principal Investigator
  
  SHIMOSE Shoji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells
- Principal Investigator
  
  SHIMOSE Shouji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  HIROSHIMA UNIVERSITY

All 2019 2016 2014 2012 2011 2010 2009 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Novel Near-Infrared Fluorescence-Guided Surgery With Vesicular Stomatitis Virus for Complete Surgical Resection of Osteosarcomas in Mice.2019
- Author(s)
  Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Nakanishi M, Ochi M, Adachi N.
- Journal Title
  
  J Orthop Res.
  
  Volume: Epub ahead of print] Issue: 5 Pages: 1192-1201
- DOI
  10.1002/jor.24277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10970
[Journal Article] Percent slope analysis of dynamic magnetic resonance imaging for assessment of chemotherapy response of osteosarcoma or Ewing sarcoma2016
- Author(s)
  Kubo T, Furuta T, Johan MP, Ochi M, Adachi N
- Journal Title
  
  Skeletal Radiology
  
  Volume: 45 Issue: 9 Pages: 1235-1242
- DOI
  10.1007/s00256-016-2410-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462267
[Journal Article] Prognostic significance of (18)F-FDG PET at diagnosis in patients with soft tissue sarcoma and bone sarcoma2016
- Author(s)
  Kubo T, Furuta T, Johan MP, Ochi M
- Journal Title
  
  European Journal of Cancer
  
  Volume: 58 Pages: 104-111
- DOI
  10.1016/j.ejca.2016.02.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462267
[Journal Article] Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration2014
- Author(s)
  Shinbo K, Miyaki S, Ishitobi H, Kato Y, Kubo T, Shimose S, Ochi M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 445 Issue: 2 Pages: 381-387
- DOI
  10.1016/j.bbrc.2014.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592235, KAKENHI-PROJECT-24689057, KAKENHI-PROJECT-25253089
[Journal Article] Minodronate for the treatment of osteoporosis.2010
- Author(s)
  Kubo Tadahiko
- Journal Title
  
  Drugs Today
  
  Volume: 46(1) Pages: 33-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591916
[Journal Article] Minodronate for the treatment of osteoporosis2010
- Author(s)
  Kubo T, Shimose S, Matsuo T, FujimoriJ, Ochi M.
- Journal Title
  
  Drugs Today(Barc)
  
  Volume: 46(1) Pages: 33-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591916
[Journal Article] Lipophilic bisphosphonates as dualfarnesyl/ geranylgeranyl diphosphate synthase inhibitors : an X-ray and NMRinvestigation2009
- Author(s)
  Zhang Y, Cao R, Yin F, Hudock MP, GuoRT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, LeonA, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, KuboT, Ochi M, Mukkamala D, Oldfield E.
- Journal Title
  
  J Am Chem Soc
  
  Volume: 131(14) Pages: 5153-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591916
[Journal Article] 殺腫瘍ウイルスvesicular stomatitis virusの悪性骨腫瘍細胞に対する選択的抗腫瘍効果2007
- Author(s)
  久保忠彦
- Journal Title
  
  日本整形外科学会雑誌 81
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591633
[Journal Article] Antitumor effects of vesicular stomatitis virus for malignant bone Tumors2007
- Author(s)
  T., Kubo, S., Shimose, T., Matsuo, M., Ochi
- Journal Title
  
  The Journal of theJapanese Orthopaedic Association 81
  
  Pages: 911-911
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591633
[Journal Article] Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells2006
- Author(s)
  Tadahiko Kubo
- Journal Title
  
  Journal of Orthopaedic research (in press)
- NAID
  120000875882
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591491
[Journal Article] 悪性骨腫瘍に対する新規ビスフォスフォネートminodronateのブロードスペクトラムな抗腫瘍効果2005
- Author(s)
  久保忠彦
- Journal Title
  
  日本整形外科学会雑誌 79・8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591491
[Journal Article] 骨肉腫、軟骨肉腫に対する第三世代bisphosphonateの腫瘍増殖、腫瘍浸潤抑制効果2005
- Author(s)
  久保忠彦
- Journal Title
  
  日本整形外科学会雑誌 79・6
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591491
[Journal Article] 骨肉腫に対する第三世代ビスフォスフォネート、活性型ビタミンD3の分化誘導、抗腫瘍効果2004
- Author(s)
  久保忠彦
- Journal Title
  
  日本整形外科学会雑誌 78・8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591491
[Journal Article] Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells
- Author(s)
  Kubo T
- Journal Title
  
  Journal of Orthopaedic Research (in press)
- NAID
  120000875882
- Data Source
  KAKENHI-PROJECT-16591491
[Journal Article] Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines.
- Author(s)
  Fujimori J, Matsuo T, Shimose S, Kubo T, Ishikawa M, Yasunaga Y, Ochi M.
- Journal Title
  
  Journal of Orthopaedic Research. in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591757
[Journal Article] Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells
- Author(s)
  Kubo T
- Journal Title
  
  Journal of Orthopaedic Research (in press)
- NAID
  120000875882
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591491
[Presentation] Tumor-suppressor microRNA導入遺伝子組み換え腫瘍溶解性ウイルスの開発2019
- Author(s)
  作田智彦、久保忠彦、古田太輔、安達伸生
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K10970
[Presentation] Novel Near-Infrared Fluorescence-Guided Surgery With Vesicular Stomatitis Virus for Complete Surgical Resection of Osteosarcomas in Mice.2019
- Author(s)
  Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Nakanishi M, Ochi M, Adachi N.
- Organizer
  19th Ground Round of Musculoskeletal Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10970
[Presentation] Novel near-infrared fluorescence-guided surgery with vesicular stomatitis virus for complete surgical resection of osteosarcomas in mice2019
- Author(s)
  Tomohiko Sakuda, Tadahiko Kubo, Muhammad Petrus Johan, Taisuke Furuta, Mitsuo Ochi, Nobuo Adachi
- Organizer
  19th Grand Round Musculoskeletal Oncology (Indonesia)
- Data Source
  KAKENHI-PROJECT-17K10970
[Presentation] Comprehensive approach of fluorescence-guided resection combined with systemic virotherapy by VSV2019
- Author(s)
  作田智彦、久保忠彦、古田太輔、Muhammad Petrus Johan、安達伸生
- Organizer
  第52回日本整形外科骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-17K10970
[Presentation] Prognostic significance of Positron Emission Tomography in patients with sarcoma2016
- Author(s)
  久保忠彦、古田太輔、越智光夫、下瀬省二、藤森淳
- Organizer
  第89回日本整形外科学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26462267
[Presentation] Cancer immunotherapy with novel bisphosphonates for bone metastasis2012
- Author(s)
  Tadahiko Kubo
- Organizer
  2012 ANNUAL MEETING OF AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
- Place of Presentation
  Moscone Center, San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-21591916
[Presentation] Cancer immunotherapy with novel bisphosphonates for bone metastasis2012
- Author(s)
  Tadahiko Kubo, Shoji Shimose, Toshihiro Matsuo, Jun Fujimori, and Mitsuo Ochi
- Organizer
  2012 annual meeting of american academy of orthopaedic surgeons
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-21591916
[Presentation] Inhibition of Cell Growth by G-quadruplex-interactive Agent in Osteosarcoma Cells2011
- Author(s)
  藤森淳, 松尾俊宏, 下瀬省二, 久保忠彦, 越智光夫
- Organizer
  Orthopaedic Research Society 2011 Annual Meeting
- Place of Presentation
  米国Long beach
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] 転移性骨腫瘍に対する新規ビスフォスフォネートの開発2011
- Author(s)
  久保忠彦
- Organizer
  第44回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  京都国際会議場(京都府)
- Data Source
  KAKENHI-PROJECT-21591916
[Presentation] 転移性骨腫瘍に対する新規ビスフォスフォネートの開発2011
- Author(s)
  久保忠彦、下瀬省二、藤森淳、越智光夫
- Organizer
  第44回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  京都府
- Data Source
  KAKENHI-PROJECT-21591916
[Presentation] Inhibition of cell growth by G-quadruplex-interactive agent in osteosarcoma cells.2011
- Author(s)
  Fujimori J, Matsuo T, Shimose S, Kubo T, Ochi M
- Organizer
  Orthopaedic Research Society 2011 Annual Meeting
- Place of Presentation
  Long Beach, USA.
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] 骨・軟部腫瘍のテロメア・テロメラーゼ2010
- Author(s)
  松尾俊宏, 下瀬省二, 久保忠彦, 藤森淳, 越智光夫
- Organizer
  第49回鹿児島整形外科懇話会
- Place of Presentation
  鹿児島市
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines.2010
- Author(s)
  Fujimori J, Matsuo T, Shimose S, Kubo T, Yasunaga Y, Ochi M
- Organizer
  Orthopaedic Research Society 2010 Annual Meeting
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] テロメラーゼ阻害剤による骨肉腫細胞への抗腫瘍効果2009
- Author(s)
  藤森淳, 下瀬省二, 久保忠彦, 松尾俊宏, 安永裕司, 越智光夫
- Organizer
  第24回日本整形外科学会基礎学術集会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-20591757
[Presentation] 殺腫瘍ウイルスVSVの悪性骨腫瘍細胞に対する選択的抗腫瘍効果2007
- Author(s)
  久保忠彦
- Organizer
  第22回日本整形外科学会基礎学術集会
- Place of Presentation
  浜松市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591633
[Presentation] Antitumor effects of vesicular stomatitis virus for malignant bone Tumors2007
- Author(s)
  T., Kubo, S., Shimose, T., Matsuo, M., Ochi
- Organizer
  The Journal of the Japanese Orthopaedic Association
- Place of Presentation
  Hamamatsu
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591633

1. SHIMOSE Shouji (30304439)

# of Collaborated Projects: 9 results

# of Collaborated Products: 13 results
2. OCHI Mitsuo (70177244)

# of Collaborated Projects: 8 results

# of Collaborated Products: 16 results
3. MATSUO Toshihiro (90397977)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. SAKAGUCHI Takemasa (70196070)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. MIYAKI Shigeru (10392490)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. FUJIMORI Jun (70632256)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. YASUNAGA Yuji (40253075)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Furuta Taisuke (30781645)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
9. 安達伸生 (30294383)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
10. HIYAMA Eiso (00218744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SAKAI Akira (70284221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUBO Tadahiko 久保 忠彦

Research Projects

Research Products

Co-Researchers

Development of a novel delivery system and osteosarcoma therapy using down-regulated MSC-derived exosomes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multimodal therapy by microRNA-encoding oncolytic virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Fluorescent tumor cell detection by tumor-specific virus VSV for precise osteosarcoma resectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel Medical therapy using Telomerase Inhibitor TMPyP4 for Osteosarcoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exosome-formed miRNA for the treatment of osteosarcoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Magnetic targeting therapy with new bisphosphonates for the treatment of bone metastasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Target therapy in bone and soft tissue sarcomas using magnetic liposomal telomerase inhibitor under an external magnetic force

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeted delivery of magnetic Iiposome encapsulated platelet rich plasma for bone formation in a rat bone-defect model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolated limb perfusion for vesicular stomatitis virus delivery in sarcoma-bearing ratsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anticancer therapy with liposomes combined with fluorodeoxyglucose (FDG) using as a tumor detection agent in position emission tomography (PET)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Novel Near-Infrared Fluorescence-Guided Surgery With Vesicular Stomatitis Virus for Complete Surgical Resection of Osteosarcomas in Mice.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Percent slope analysis of dynamic magnetic resonance imaging for assessment of chemotherapy response of osteosarcoma or Ewing sarcoma2016

Author(s)

Journal Title

DOI

Data Source

KUBO Tadahiko 久保忠彦