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TAKAHASHI Manabu  高橋 学

ORCIDConnect your ORCID iD *help
Researcher Number 70406122
Other IDs
Affiliation (based on the past Project Information) *help 2021 – 2022: 自治医科大学, 医学部, 客員研究員
2015 – 2020: 自治医科大学, 医学部, 講師
2013 – 2014: 自治医科大学, 医学部, 助教
2007: Jichi Medical Univetsity, Department of Medicine, Post Graduated Student
Review Section/Research Field
Principal Investigator
Basic Section 54040:Metabolism and endocrinology-related / Experimental pathology
Except Principal Investigator
Metabolomics / Biological Sciences
Keywords
Principal Investigator
マクロファージ / 肥満 / コレステロールエステル加水分解酵素 / NCEH1 / 糖尿病 / 遺伝子 / 細胞・組織 / 酵素 / 脂質 / 線維化 / 炎症 / リポ蛋白リパーゼ … More
Except Principal Investigator
… More マウス / コレステロール / 肝臓 / 脂肪酸 / リパーゼ / liver dysfunction / knockout / mouse / albumin / liver / squalene synthase / HMG-CoA reductase / cholesterol / 細胞増殖 / ミエリン / 血管平滑筋細胞 / スクアレン合成酵素 / HMG-CoA還元酵素 / 肝障害 / ノックアウト / アルブミン / スクワレン合成酵素 / IMG-CoA還元酵素 / エステル / アポトーシス / 小胞体 / 加水分解 / 酵素 / オキシステロール / 小胞体ストレス / トランスジェニック / マクロファージ / 泡沫細胞 / 動脈硬化 / 脂質代謝 / リポ蛋白リパーゼ / インスリン抵抗性 / 遺伝子発現 / ヒト / 肥満 / トリグリセリド / 脂肪細胞 Less
  • Research Projects

    (6 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (13 People)
  •  The role of NCEH1 in obesityPrincipal Investigator

    • Principal Investigator
      Takahashi Manabu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Jichi Medical University
  •  Myeloid lipoprotein lipase determines obesity-induced adipose tissue fibrosisPrincipal Investigator

    • Principal Investigator
      Takahashi Manabu
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Jichi Medical University
  •  Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages

    • Principal Investigator
      ISHIBASHI SHUN
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicity

    • Principal Investigator
      YAGYU Hiroaki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  脂肪細胞内lipolysisの分子機構

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Jichi Medical University
  •  Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in mice

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University

All 2022 2019 2017 2015 2014 2013 2007 Other

All Journal Article Presentation Other

  • [Journal Article] Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice2022

    • Author(s)
      Takahashi M, Yamamuro D, Wakabayashi T, Takei A, Takei S, Nagashima S, Okazaki H, Ebihara K, Yagyu H, Takayanagi Y, Onaka T, Goldberg IJ, Ishibashi S.
    • Journal Title

      J Biol Chem

      Volume: 298 Issue: 9 Pages: 102322-102322

    • DOI

      10.1016/j.jbc.2022.102322

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-20K08870, KAKENHI-PROJECT-23K21443, KAKENHI-PROJECT-19H03712
  • [Journal Article] AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.2022

    • Author(s)
      Shibuya K, Ebihara K, Ebihara C, Sawayama N, Isoda M, Yamamuro D, Takahashi M, Nagashima S, Ishibashi S
    • Journal Title

      J Biol Chem

      Volume: 298 Issue: 6 Pages: 101936-101936

    • DOI

      10.1016/j.jbc.2022.101936

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-20K08870, KAKENHI-PROJECT-19H03712
  • [Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015

    • Author(s)
      Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 56 Issue: 5 Pages: 998-1005

    • DOI

      10.1194/jlr.m057406

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
  • [Journal Article] Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.2015

    • Author(s)
      Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 466(3) Issue: 3 Pages: 536-540

    • DOI

      10.1016/j.bbrc.2015.09.065

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15344, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03093, KAKENHI-PROJECT-13J00607, KAKENHI-PROJECT-26560391, KAKENHI-PROJECT-26560392, KAKENHI-PROJECT-25293213, KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-15H03092
  • [Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014

    • Author(s)
      Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 55 Issue: 10 Pages: 2033-2040

    • DOI

      10.1194/jlr.m047787

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
  • [Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014

    • Author(s)
      Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 55 Issue: 10 Pages: 2082-2092

    • DOI

      10.1194/jlr.m050864

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
  • [Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013

    • Author(s)
      Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 54(4) Issue: 4 Pages: 1124-34

    • DOI

      10.1194/jlr.m035568

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339, KAKENHI-PROJECT-25293213
  • [Journal Article] Sterol regulatory element-binding protein(SREBP) -1-independent regulation of lipogenic gene expression in adipocytes2007

    • Author(s)
      Sekiya, M., Yahagi, N., Matsuzaka, T., Takeuchi, Y., Nakagawa, Y., Takahashi, H., Okazaki, H., Iizuka Y, Ohashi, K., Gotoda, T., Ishibashi, S., Nagai, R., Yamazaki, T., Kadowaki, T., Yamada, N., Osuga, JI., Shimano, H
    • Journal Title

      J Lipid Res 48(7)

      Pages: 1581-1591

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Presentation] 細胞外トリグリセリド分解と肥満・脂肪組織線維化2019

    • Author(s)
      高橋 学、石橋俊
    • Organizer
      第40回日本肥満学会・学術集会
    • Data Source
      KAKENHI-PROJECT-16K21318
  • [Presentation] 肥満脂肪組織慢性炎症誘導におけるマクロファージ由来リポ蛋白リパーゼの意義2017

    • Author(s)
      高橋 学, 野牛 宏晃, 永島 秀一, 若林 徹治, 山室 大介, 山崎 久隆, 武井 祥子, 武井 暁一, 海老原 健, 石橋 俊
    • Organizer
      第49回日本動脈硬化学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-16K21318
  • []

  • 1.  NAGASHIMA Syuichi (30406136)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 2.  ISHIBASHI Shun (90212919)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 3.  WANG Xiao li (10458325)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  TAZOE Fumiko (20406127)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  YAGYU Hiroaki (60348018)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  加藤 秀樹 (20406094)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  OKAZAKI Hiroaki (80610211)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  YAMAMURO DAISUKE (20739255)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  坂井 謙斗 (30646352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  大須賀 淳一 (10334400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 11.  板橋 直樹 (00316522)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  中川 嘉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  島野 仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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