TAKAHASHI Manabu 高橋学

Researcher Number	70406122
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2022: 自治医科大学, 医学部, 客員研究員 2015 – 2020: 自治医科大学, 医学部, 講師 2013 – 2014: 自治医科大学, 医学部, 助教 2007: Jichi Medical Univetsity, Department of Medicine, Post Graduated Student
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Experimental pathology Except Principal Investigator Metabolomics / Biological Sciences
Keywords	Principal Investigator マクロファージ / 肥満 / コレステロールエステル加水分解酵素 / NCEH1 / 糖尿病 / 遺伝子 / 細胞・組織 / 酵素 / 脂質 / 線維化 / 炎症 / リポ蛋白リパーゼ … More Except Principal Investigator … More マウス / コレステロール / 肝臓 / 脂肪酸 / リパーゼ / liver dysfunction / knockout / mouse / albumin / liver / squalene synthase / HMG-CoA reductase / cholesterol / 細胞増殖 / ミエリン / 血管平滑筋細胞 / スクアレン合成酵素 / HMG-CoA還元酵素 / 肝障害 / ノックアウト / アルブミン / スクワレン合成酵素 / IMG-CoA還元酵素 / エステル / アポトーシス / 小胞体 / 加水分解 / 酵素 / オキシステロール / 小胞体ストレス / トランスジェニック / マクロファージ / 泡沫細胞 / 動脈硬化 / 脂質代謝 / リポ蛋白リパーゼ / インスリン抵抗性 / 遺伝子発現 / ヒト / 肥満 / トリグリセリド / 脂肪細胞 Less

The role of NCEH1 in obesityPrincipal Investigator
- Principal Investigator
  
  Takahashi Manabu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Jichi Medical University
Myeloid lipoprotein lipase determines obesity-induced adipose tissue fibrosisPrincipal Investigator
- Principal Investigator
  
  Takahashi Manabu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Jichi Medical University
Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages
- Principal Investigator
  
  ISHIBASHI SHUN
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicity
- Principal Investigator
  
  YAGYU Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
脂肪細胞内lipolysisの分子機構
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in mice
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University

All 2022 2019 2017 2015 2014 2013 2007 Other

All Journal Article Presentation Other

[Journal Article] Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice2022
- Author(s)
  Takahashi M, Yamamuro D, Wakabayashi T, Takei A, Takei S, Nagashima S, Okazaki H, Ebihara K, Yagyu H, Takayanagi Y, Onaka T, Goldberg IJ, Ishibashi S.
- Journal Title
  
  J Biol Chem
  
  Volume: 298 Issue: 9 Pages: 102322-102322
- DOI
  10.1016/j.jbc.2022.102322
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-20K08870, KAKENHI-PROJECT-23K21443, KAKENHI-PROJECT-19H03712
[Journal Article] AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.2022
- Author(s)
  Shibuya K, Ebihara K, Ebihara C, Sawayama N, Isoda M, Yamamuro D, Takahashi M, Nagashima S, Ishibashi S
- Journal Title
  
  J Biol Chem
  
  Volume: 298 Issue: 6 Pages: 101936-101936
- DOI
  10.1016/j.jbc.2022.101936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-20K08870, KAKENHI-PROJECT-19H03712
[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015
- Author(s)
  Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 56 Issue: 5 Pages: 998-1005
- DOI
  10.1194/jlr.m057406
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.2015
- Author(s)
  Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 466(3) Issue: 3 Pages: 536-540
- DOI
  10.1016/j.bbrc.2015.09.065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15344, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03093, KAKENHI-PROJECT-13J00607, KAKENHI-PROJECT-26560391, KAKENHI-PROJECT-26560392, KAKENHI-PROJECT-25293213, KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-15H03092
[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014
- Author(s)
  Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2033-2040
- DOI
  10.1194/jlr.m047787
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533
[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014
- Author(s)
  Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 55 Issue: 10 Pages: 2082-2092
- DOI
  10.1194/jlr.m050864
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293213, KAKENHI-PROJECT-26870533, KAKENHI-PROJECT-26253009
[Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013
- Author(s)
  Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 54(4) Issue: 4 Pages: 1124-34
- DOI
  10.1194/jlr.m035568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339, KAKENHI-PROJECT-25293213
[Journal Article] Sterol regulatory element-binding protein(SREBP) -1-independent regulation of lipogenic gene expression in adipocytes2007
- Author(s)
  Sekiya, M., Yahagi, N., Matsuzaka, T., Takeuchi, Y., Nakagawa, Y., Takahashi, H., Okazaki, H., Iizuka Y, Ohashi, K., Gotoda, T., Ishibashi, S., Nagai, R., Yamazaki, T., Kadowaki, T., Yamada, N., Osuga, JI., Shimano, H
- Journal Title
  
  J Lipid Res 48(7)
  
  Pages: 1581-1591
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] 細胞外トリグリセリド分解と肥満・脂肪組織線維化2019
- Author(s)
  高橋　学、石橋俊
- Organizer
  第40回日本肥満学会・学術集会
- Data Source
  KAKENHI-PROJECT-16K21318
[Presentation] 肥満脂肪組織慢性炎症誘導におけるマクロファージ由来リポ蛋白リパーゼの意義2017
- Author(s)
  高橋　学, 野牛宏晃, 永島秀一, 若林徹治, 山室大介, 山崎久隆, 武井祥子, 武井暁一, 海老原健, 石橋俊
- Organizer
  第49回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K21318
[]

1. NAGASHIMA Syuichi (30406136)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. ISHIBASHI Shun (90212919)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. WANG Xiao li (10458325)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAZOE Fumiko (20406127)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAGYU Hiroaki (60348018)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 加藤秀樹 (20406094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OKAZAKI Hiroaki (80610211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAMAMURO DAISUKE (20739255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 坂井謙斗 (30646352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 大須賀淳一 (10334400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. 板橋直樹 (00316522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中川嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 島野仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI Manabu 高橋 学

Research Projects

Research Products

Co-Researchers

The role of NCEH1 in obesityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Myeloid lipoprotein lipase determines obesity-induced adipose tissue fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel therapy for atherosclerosis based on alleviation of lipotoxicity of macrophages

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脂肪細胞内lipolysisの分子機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sterol regulatory element-binding protein(SREBP) -1-independent regulation of lipogenic gene expression in adipocytes2007

Author(s)

Journal Title

Description

Data Source

TAKAHASHI Manabu 高橋学