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Matsumoto Takumi  松本 卓巳

ORCIDConnect your ORCID iD *help
Researcher Number 70436468
Other IDs
Affiliation (Current) 2025: 東京大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help 2019 – 2024: 東京大学, 医学部附属病院, 講師
2018: 東京大学, 医学部附属病院, 助教
2016 – 2018: 東京大学, 医学部附属病院, 特任准教授
2017: 東京大学, 医学部附属病院, その他
Review Section/Research Field
Principal Investigator
Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Except Principal Investigator
Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Keywords
Principal Investigator
変形性関節症 / 自然リンパ球 / 炎症性関節疾患 / 骨粗鬆症 / マクロファージ / Hhex / エピジェネティック制御 / ヒストン修飾 / エピジェネティクス / エピジェネティック修飾 … More / 破骨細胞 / 動物モデル / 軟骨 / 足関節軟骨 / 膝関節軟骨 / 軟骨代謝 / 膝関節 / 足関節 … More
Except Principal Investigator
関節リウマチ / 変形性関節症 / シングルセル解析 / マクロファージ分化 / 異物排除と寛容 / マウス腹腔内異物投与モデル / 破骨細胞 / カルシウム振動 / 異物反応 / 異物巨細胞 / 靭帯骨化 / 骨化様式 / Wntシグナル / メカニカルストレス / 間葉系幹細胞 / 靱帯骨化 / 靱帯 / 骨密度 / CTを用いた有限要素解析 / 骨強度 / 有限要素解析 / 骨粗鬆症 Less
  • Research Projects

    (7 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (17 People)
  •  関節滑膜の3型自然リンパ球による変形性関節症の制御機構の解明Principal Investigator

    • Principal Investigator
      松本 卓巳
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  Elucidation of the mechanism of arthritis and establishment of therapeutic strategy by tissue-specific phenotyping

    • Principal Investigator
      小俣 康徳
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  Transcription factor Hhex regulates bone homeostasis by negatively regulating osteoclast differentiationPrincipal Investigator

    • Principal Investigator
      Matsumoto Takumi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  Differentiation mechanism of foreign body giant cells

    • Principal Investigator
      Matsubara Takehiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      The University of Tokyo
  •  靭帯骨化に関わる細胞集団とシグナル連関の解明

    • Principal Investigator
      佐藤 雄亮
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      The University of Tokyo
  •  Investigation of cartilage homeostasis and molecular biology by comparison of ankle and knee jointPrincipal Investigator

    • Principal Investigator
      Matsumoto Takumi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      The University of Tokyo
  •  Support tools for evaluating osteoporosis therapeutic effects with rheumatoid arthritis patients

    • Principal Investigator
      Tanaka Sakae
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Orthopaedic surgery
    • Research Institution
      The University of Tokyo

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

  • [Journal Article] Changes in knee joint destruction patterns among patients with rheumatoid arthritis undergoing total knee arthroplasty in recent decades2023

    • Author(s)
      Takeda Ryutaro、Matsumoto Takumi、Omata Yasunori、Inui Hiroshi、Taketomi Shuji、Nagase Yuichi、Nishikawa Takuji、Oka Hiroyuki、Tanaka Sakae
    • Journal Title

      Clinical Rheumatology

      Volume: 42 Issue: 9 Pages: 2341-2352

    • DOI

      10.1007/s10067-023-06620-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Associated correction of forefoot alignment with hindfoot fusion for pes planovalgus deformity2023

    • Author(s)
      Matsumoto Takumi、Takeda Ryutaro、Uchio Akihiro、Mizuhara Hiroyasu、Omata Yasunori、Juji Takuo、Tanaka Sakae
    • Journal Title

      Foot and Ankle Surgery

      Volume: 29 Issue: 3 Pages: 280-287

    • DOI

      10.1016/j.fas.2023.02.012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] The discrepancy between radiographically-assessed and self-recognized hallux valgus in a large population-based cohort2022

    • Author(s)
      Matsumoto Takumi、Higuchi Junya、Maenohara Yuji、Chang Song Ho、Iidaka Toshiko、Horii Chiaki、Oka Hiroyuki、Muraki Shigeyuki、Hashizume Hiroshi、Yamada Hiroshi、Yoshida Munehito、Nakamura Kozo、Tanaka Sakae、Yoshimura Noriko
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 23 Issue: 1 Pages: 31-31

    • DOI

      10.1186/s12891-021-04978-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09306, KAKENHI-PROJECT-21K09316, KAKENHI-PROJECT-21K19631, KAKENHI-PROJECT-19H03895, KAKENHI-PROJECT-19K19454
  • [Journal Article] Transcription Factor Hematopoietically Expressed Homeobox Protein (Hhex) Negatively Regulates Osteoclast Differentiation by Controlling Cyclin‐Dependent Kinase Inhibitors2022

    • Author(s)
      Watanabe Hisato、Okada Hiroyuki、Hirose Jun、Omata Yasunori、Matsumoto Takumi、Matsumoto Morio、Nakamura Masaya、Saito Taku、Miyamoto Takeshi、Tanaka Sakae
    • Journal Title

      JBMR Plus

      Volume: 6 Issue: 4

    • DOI

      10.1002/jbm4.10608

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08246, KAKENHI-PROJECT-20K22973, KAKENHI-PROJECT-21K16703, KAKENHI-PROJECT-21K09316, KAKENHI-PROJECT-21H03057
  • [Journal Article] Clinical Outcomes After First Metatarsophalangeal Joint Arthrodesis by Flat Cut Joint Preparation With Individual Adjustment for Sagittal Alignment2022

    • Author(s)
      Matsumoto Takumi、Takeda Ryutaro、Kasai Taro、Chang Song Ho、Izawa Naohiro、Hirose Jun、Takuo Juji、Tanaka Sakae
    • Journal Title

      The Journal of Foot and Ankle Surgery

      Volume: 61 Issue: 1 Pages: 60-66

    • DOI

      10.1053/j.jfas.2020.10.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Outcomes of Scarf and Akin Osteotomy with Intra-Articular Stepwise Lateral Soft Tissue Release for Correcting Hallux Valgus Deformity in Rheumatoid Arthritis2021

    • Author(s)
      Matsumoto Takumi、Maenohara Yuji、Chang Song Ho、Ono Kumiko、Omata Yasunori、Hirose Jun、Tanaka Sakae
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 20 Pages: 10667-10667

    • DOI

      10.3390/ijerph182010667

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Comparison between suture and staple fixations as internal fixation techniques for Akin osteotomy2021

    • Author(s)
      Matsumoto Takumi、Takeda Ryutaro、Maenohara Yuji、Chang Song Ho、Omata Yasunori、Takuo Juji、Tanaka Sakae
    • Journal Title

      Foot and Ankle Surgery

      Volume: - Issue: 1 Pages: 100-106

    • DOI

      10.1016/j.fas.2021.02.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23599, KAKENHI-PROJECT-21K09316
  • [Journal Article] 人工足関節全置換術と足関節固定術はどのように使い分けるべきか?2021

    • Author(s)
      松本卓巳
    • Journal Title

      LOCO CURE

      Volume: - Pages: 45-47

    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Systemic inflammatory responses after orthopedic surgery in patients with rheumatoid arthritis treated with tofacitinib2021

    • Author(s)
      Uchio Akihiro、Matsumoto Takumi、Maenohara Yuji、Omata Yasunori、Takahashi Hiroshi、Iwasawa Mitsuyasu、Juji Takuo、Nakamura Ichiro、Tanaka Sakae
    • Journal Title

      Clinical Rheumatology

      Volume: 40 Issue: 12 Pages: 5077-5083

    • DOI

      10.1007/s10067-021-05914-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Treatment with an active vitamin D analogue blocks hypothalamic dysfunction-induced bone loss in mice2021

    • Author(s)
      Ito E, Sato Y, Kobayashi T, Nakamura S, Kaneko Y, Soma T, Matsumoto T, Kimura A, Miyamoto K, Matsumoto H, Matsumoto M, Nakamura M, Sato K, Miyamoto T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 542 Pages: 48-53

    • DOI

      10.1016/j.bbrc.2021.01.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09580, KAKENHI-PROJECT-20K09461, KAKENHI-PROJECT-18H02930, KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-19K09655, KAKENHI-PROJECT-21K21096
  • [Journal Article] Juvenile Dysplasia Epiphysealis Hemimelica with Multiple Ankle Free Body2021

    • Author(s)
      Sato Shinsuke、Chang Song Ho、Kasai Taro、Maenohara Yuji、Yamazawa Sho、Tanaka Sakae、Matsumoto Takumi
    • Journal Title

      Case Reports in Orthopedics

      Volume: 2021 Pages: 1-8

    • DOI

      10.1155/2021/5579684

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Symptomatic Medial Bone Excrescence in the Distal Phalanx of the Hallux after the First Metatarsophalangeal Joint Arthrodesis: A Case Report and Radiographic Reviews2021

    • Author(s)
      Maenohara Yuji、Takeda Ryutaro、Chang Song Ho、Omata Yasunori、Tanaka Sakae、Matsumoto Takumi
    • Journal Title

      Case Reports in Orthopedics

      Volume: 2021 Pages: 1-6

    • DOI

      10.1155/2021/6035784

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Effect of gait protocols and postoperative shoes on off-loading of forefoot in preoperative patients for forefoot disorders2021

    • Author(s)
      Kasai Taro、Tsuji Marina、Takeda Ryutaro、Chang Song Ho、Anzai Emi、Nakajima Kanako、Tanaka Sakae、Ohta Yuji、Matsumoto Takumi
    • Journal Title

      Modern Rheumatology

      Volume: - Issue: 6 Pages: 1186-1192

    • DOI

      10.1093/mr/roab093

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09316, KAKENHI-PROJECT-18K18363
  • [Journal Article] Surgical Treatment of Pathological Tibial Shaft Fracture in Adult Patient With Gnathodiaphyseal Dysplasia2021

    • Author(s)
      Takeda Ryutaro、Yasui Tetsuro、Kasai Taro、Matsumoto Takumi、Matsubara Takehiro、Tanaka Sakae
    • Journal Title

      JBJS Case Connector

      Volume: 11 Issue: 2

    • DOI

      10.2106/jbjs.cc.21.00005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-21K09316
  • [Journal Article] A ‘Giving way’ captured during walking by gyroscopes and plantar force sensors2021

    • Author(s)
      Takeda Ryutaro、Nakajima Kanako、Anzai Emi、Tanaka Sakae、Ohta Yuji、Matsumoto Takumi
    • Journal Title

      Journal of Biomechanics

      Volume: 129 Pages: 110754-110754

    • DOI

      10.1016/j.jbiomech.2021.110754

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09316, KAKENHI-PROJECT-18K18363
  • [Journal Article] 足関節・足部の骨折2021

    • Author(s)
      松本卓巳
    • Journal Title

      今日の治療指針 2021年度

      Volume: - Pages: 1162-1162

    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Journal Article] Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw2020

    • Author(s)
      Soma T, Iwasaki R, Sato Y, Kobayashi T, Nakamura S, Kaneko Y, Ito E, Okada H, Watanabe H, Miyamoto K, Matsumoto M, Nakamura M, Asoda S, Kawana H, Nakagawa T, Miyamoto T
    • Journal Title

      J Bone Miner Metab

      Volume: - Issue: 3 Pages: 372-384

    • DOI

      10.1007/s00774-020-01174-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09580, KAKENHI-PROJECT-19K10365, KAKENHI-PROJECT-20K09461, KAKENHI-PROJECT-18H02930, KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-19K09655
  • [Journal Article] Lubricin Contributes to Homeostasis of Articular Cartilage by Modulating Differentiation of Superficial Zone Cells2020

    • Author(s)
      Maenohara Yuji、Chijimatsu Ryota、Tachibana Naohiro、Uehara Kosuke、Xuan Fengjun、Mori Daisuke、Murahashi Yasutaka、Nakamoto Hideki、Oichi Takeshi、Chang Song Ho、Matsumoto Takumi、Omata Yasunori、Yano Fumiko、Tanaka Sakae、Saito Taku
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 36 Issue: 4 Pages: 792-802

    • DOI

      10.1002/jbmr.4226

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-20K09451, KAKENHI-PROJECT-20K09452, KAKENHI-PROJECT-20K18053, KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-18K09055, KAKENHI-PROJECT-19K22677, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-20K09428, KAKENHI-PROJECT-21K16690, KAKENHI-PROJECT-20K09405, KAKENHI-PROJECT-18K09019
  • [Journal Article] CTLA4-Ig directly inhibits osteoclastogenesis by interfering with intracellular calcium oscillations in bone marrow macrophages.2019

    • Author(s)
      Okada H, Kajiya H, Omata Y, Matsumoto T, Sato Y, Kobayashi T, Nakamura S, Kaneko Y, Nakamura S, Koyama T, Sudo S, Shin M, Okamoto F, Watanabe H, Tachibana N, Hirose J, Saito T, Takai T, Matsumoto M, Nakamura M, Okabe K, Miyamoto T, Tanaka S.
    • Journal Title

      J Bone Miner Res

      Volume: 34 Issue: 9 Pages: 1744-1752

    • DOI

      10.1002/jbmr.3754

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-19K09580, KAKENHI-PROJECT-19K10301, KAKENHI-PROJECT-18H02930, KAKENHI-PROJECT-19H03822
  • [Presentation] 大規模住民コホートスタディからみた関節リウマチ関連バイオマーカー陽性者の中期6年の予後調査2023

    • Author(s)
      真壁 健太、松本 卓巳
    • Organizer
      第67回日本リウマチ学会総会・学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] 関節リウマチの中後足部変形に対する治療戦略2021

    • Author(s)
      松本卓巳
    • Organizer
      第9回文京整形外科合同カンファレンス
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] 一般住民における外反母趾の自覚率とその影響因子:大規模住民コホートROAD studyより2021

    • Author(s)
      松本卓巳、武田龍太郎、内尾明博、樋口淳也、前之原悠司、笠井太郎、張成虎、田中栄
    • Organizer
      第46回日本足の外科学会・学術集会
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] 半拘束型人工肘関節Discoveryの使用成績2021

    • Author(s)
      小俣康徳、松本卓巳、田中栄
    • Organizer
      第50回日本リウマチの外科学会
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] 変形性膝関節症様の特徴をもつ関節リウマチ・膝関節症患者の増加~AIによる検証~2021

    • Author(s)
      武田龍太郎、松本卓巳、前之原悠司、小俣康徳、永瀬雄一、西川卓治、田中栄
    • Organizer
      第50回日本リウマチの外科学会
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] KOACADシステムをも用いた生物学的製剤治療の有無による関節リウマチの膝関節単純X線画像的特徴についての検討2021

    • Author(s)
      小俣康徳、岡敬之、小泉泰彦、門野夕峰、大橋暁、安井哲郎、大野久美子、廣瀬旬、松本卓巳、田中栄
    • Organizer
      第65回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] 外側進入型人工足関節を用いた足関節固定から人工足関節へのconversionの小経験2021

    • Author(s)
      松本卓巳、内尾明博、前之原悠司、足達信哉、高橋寛、十字琢夫、田中栄
    • Organizer
      第46回日本足の外科学会・学術集会
    • Data Source
      KAKENHI-PROJECT-21K09316
  • [Presentation] CTLA4-Ig (Abatacept) Directly Inhibited Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations via Fc receptor gamma2020

    • Author(s)
      岡田寛之、鍛治屋浩、小俣康徳、松本卓巳、首藤俊一、進正史、岡本富士雄、廣瀬旬、岡部幸司、宮本健史、田中栄
    • Organizer
      第97回日本生理学会
    • Data Source
      KAKENHI-PROJECT-18K09017
  • [Presentation] CTLA4-Ig directly inhibited osteoclastogenesis by interfering with intracellular calcium oscillations in bone marrow macrophages2019

    • Author(s)
      Hiroyuki Okada, Hiroshi Kajiya, Yasunori Omata, Takumi Matsumoto, Shunichi Sudo, Masashi Shin, Fujio Okamoto, Jun Hirose, Koji Okabe, Takeshi Miyamoto, Sakae Tanaka
    • Organizer
      ASBMR 2019 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09017
  • [Presentation] CTLA4-Igによる破骨細胞形成直接抑制メカニズム2018

    • Author(s)
      岡田寛之、鍛冶屋浩、松本卓巳、廣瀬旬、岡部幸司、宮本健史、田中栄
    • Organizer
      20th Asia Pacific League of Associations for Rheumatology Congress、第4回日本骨免疫学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09017
  • [Presentation] Fine tuning of calcium oscillations by ITAM receptors regulates RANKL-induced osteoclast differentiation.2018

    • Author(s)
      岡田寛之、鍛冶屋浩、松本卓巳、廣瀬旬、岡部幸司、宮本健史、田中栄
    • Organizer
      ASBMR 2018 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09017
  • 1.  小俣 康徳 (40570734)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 2.  Tanaka Sakae (50282661)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 3.  岡田 慶太 (50759173)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 4.  Matsubara Takehiro (40361498)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  齋藤 琢 (30456107)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  廣瀬 旬 (00456112)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  佐藤 雄亮 (40794772)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  矢野 文子 (80529040)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  宮本 健史 (70383768)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 10.  石倉 久年 (80772904)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  土屋 遥香 (50868560)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ONO KUMIKO
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  OKA Hiroyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  橋爪 洋
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  佐藤 結子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 16.  田中 伸弥
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  森 大典
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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