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Otsuka Kouki  大塚 弘毅

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OHTSUKA Kouki  大塚 弘毅

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Researcher Number 70439165
Affiliation (Current) 2025: 杏林大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2023: 杏林大学, 医学部, 講師
2017 – 2023: 杏林大学, 医学部, 学内講師
2011 – 2016: 杏林大学, 医学部, 助教
2014: 杏林大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Respiratory surgery / Basic Section 55010:General surgery and pediatric surgery-related
Except Principal Investigator
Laboratory medicine / Basic Section 52010:General internal medicine-related / Pediatrics
Keywords
Principal Investigator
重複癌 / ゲノム編集 / メダカ / 発がん実験 / in vivo発がん実験 / Germline変異 / germline変異 / 発がんリスク / 次世代シーケンス / 生殖細胞系遺伝子変異(Germline変異) … More / がんゲノム医療 / 家族性がん / 重複がん / 毛細血管拡張性運動失調症 / ゲノム不安定性疾患 / メダカ発がん実験 / RAD50 I505fs germline変異 / 遺伝性腫瘍 / 家族性癌 / 予防 / ataxia-telangiectasia / RAD50 / ゲノム不安定性 / メダカ実験 / NGSパネル / がん関連遺伝子 / 多発癌 / 肺癌 / 家族性肺がん / 付加変異 / TP53 R248W / EGFR L858R / EGFR V843I / 遺伝性肺癌 / 家族性肺癌 / 先制医療 / 早期発見早期治療 / 予後予測 / TP53変異 / EGFR germline変異 / 肺がん / 分子シミュレーション / プロテオミクス / 遺伝子変異導入細胞 / 遺伝子改変マウス / 全ゲノムシーケンス / 遺伝性肺癌症候群 / EGFR V843I germline変異 … More
Except Principal Investigator
全ゲノム解析 / 非結核性抗酸菌 / プレアナリティカル / 皮膚消毒 / 神経損傷 / 標準採血法 / 検体保存 / 採血 / 採血法 / 測定値への影響 / マッサージ / 温罨法 / 血管怒張 / 静脈採血 / 分子動態モデリング / 分子動力学モデル / チロシンキナーゼ阻害薬 / 動的立体構造解析 / 動的分子シミュレーション / 肺癌 / チロシンキナーゼ阻害剤 / EGFR / 質量分析 / 先天異常 / JAK2 / DGKK / 先天性骨髄増殖性腫瘍 / スプライシング / GATA1 / 骨髄増殖性腫瘍 / スプライシング異常 / JAK2 / 同定不能菌 / 非定型抗酸菌 / Mycobacterium kyorinense / rpoB / 薬剤耐性 / mycobacterium celatum / mycobacterium kyorinense / 新菌種 / 感受性 / 遺伝子 / 抗酸菌 / 微生物 Less
  • Research Projects

    (8 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (12 People)
  •  Accumulation of comprehensive evidences to promote standardization of phlebotomy

    • Principal Investigator
      大西 宏明
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Kyorin University
  •  発がんリスクと考えられるGermline遺伝子変異によるin vivo発がん実験Principal Investigator

    • Principal Investigator
      大塚 弘毅
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Kyorin University
  •  fundamental research for the development of germline mutation diagnosis enabling preemptive medicine for lung cancerPrincipal Investigator

    • Principal Investigator
      Ohtsuka Kouki
    • Project Period (FY)
      2017 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      Kyorin University
  •  Construction of dynamic prediction model of EGFR tyrosine kinase inhibitors efficacy for mutated EGFR based on protein three-dimensional structure analysis

    • Principal Investigator
      Ohnishi Hiroaki
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyorin University
  •  Development of novel classification of mycobacteria by whole genome analysis and mass spectrometry

    • Principal Investigator
      Matsushima Satsuki
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyorin University
  •  Clinical and molecular biological study of hereditary lung cancer caused by EGFR germline mutationPrincipal Investigator

    • Principal Investigator
      Ohtsuka Kouki
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      Kyorin University
  •  Identification of novel non-tuberculous mycobacterium and analysis of the mechanism underlying its resistance to antibiotics

    • Principal Investigator
      MATSUSHIMA Satsuki
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyorin University
  •  Genetic analysis of a new syndrome with aberrant JAK2 splicing

    • Principal Investigator
      OHNISHI Hiroaki
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kyorin University

All 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model2023

    • Author(s)
      Chisada Shinichi、Ohtsuka Kouki、Fujiwara Masachika、Yoshida Masao、Matsushima Satsuki、Watanabe Takashi、Karita Kanae、Ohnishi Hiroaki
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 4 Pages: e0282277-e0282277

    • DOI

      10.1371/journal.pone.0282277

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08992, KAKENHI-PROJECT-23K09656, KAKENHI-PROJECT-23K09697
  • [Journal Article] Next-Generation Sequencing for Non-Ampullary Duodenal Carcinoma Suggesting the Existence of an Adenoma-Carcinoma Sequence2021

    • Author(s)
      Yoshida T, Kojima Y, Shimada R, Tanabe H, Tabei K, Yanagida O, Nikaido T, Ohtsuka K, Ohnishi H, Abe N, Hisamatsu T, Takahashi S
    • Journal Title

      Case Rep Gastroenterol

      Volume: 15 Issue: 1 Pages: 62-69

    • DOI

      10.1159/000510919

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08992
  • [Journal Article] Subtyping and EGFR mutation testing from blocks of cytological materials, based on liquid-based cytology for lung cancer at bronchoscopic examinations2020

    • Author(s)
      Ryota Tanaka, Kouki Ohtsuka
    • Journal Title

      Diagn Cytopathol

      Volume: 48(6) Issue: 6 Pages: 516-523

    • DOI

      10.1002/dc.24397

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08992
  • [Journal Article] Use of a plasma test for verifying epidermal growth factor receptor gene2020

    • Author(s)
      Ogura W, Ohtsuka K
    • Journal Title

      Respir Med Case Rep

      Volume: ? Pages: 101007-101007

    • DOI

      10.1016/j.rmcr.2020.101007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10799
  • [Journal Article] STK11 p.F354L Germline Mutation in a Case of Multiple Gastrointestinal Tumors2020

    • Author(s)
      Yohei Kojima, Kouki Ohtsuka
    • Journal Title

      Case Rep Gastroenterol

      Volume: 14(3) Issue: 3 Pages: 547-553

    • DOI

      10.1159/000508929

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08992
  • [Journal Article] Predisposition to lung adenocarcinoma in a family harboring the germline EGFR V843I mutation.2019

    • Author(s)
      Ohtsuka K, Ohnishi H, Fujiwara M, Morii T, Matsushima S, Ogura W, Yamasaki S, Kishino T, Tanaka R, Watanabe T
    • Journal Title

      JCO Precision Oncology

      Volume: - Issue: 3 Pages: 1-4

    • DOI

      10.1200/po.19.00104

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K01439, KAKENHI-PROJECT-17K10799
  • [Journal Article] APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.2018

    • Author(s)
      Kojima Y, Ohtsuka K, Ohnishi H, Abe N, Furuse J, Watanabe T, Sugiyama M.
    • Journal Title

      Surg

      Volume: 48(8) Issue: 8 Pages: 765-772

    • DOI

      10.1007/s00595-018-1649-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10799
  • [Journal Article] Whole-Genome Sequence of Mycobacterium kyorinense2014

    • Author(s)
      Ohtsuka K, Ohnishi H, Nozaki E, Matsushima S, et al.
    • Journal Title

      Genome Announcements

      Volume: 2 Issue: 5

    • DOI

      10.1128/genomea.01062-14

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590688, KAKENHI-PROJECT-24390106, KAKENHI-PROJECT-26460686
  • [Journal Article] Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense2014

    • Author(s)
      Hiroaki Ohnishi, Enrico Tortoli, Jesus Pais Ramos, Yuko Kazumi, Shota Yonetani, Satsuki Matsushima, Kouki Ohtsuka and Takashi Watanabe
    • Journal Title

      Annals of Microbiology

      Volume: 未定 Issue: 4 Pages: 1879-1882

    • DOI

      10.1007/s13213-014-0860-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590688
  • [Journal Article] Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense2014

    • Author(s)
      Ohnishi H, Tortoli E, Ramos JP, Kazumi Y, Yonetani S, Matsushima S, Ohtsuka K, Watanabe T
    • Journal Title

      Annals of Microbiology

      Volume: 64 Pages: 1879-1882

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590688
  • [Journal Article] First isolation of Mycobacterium kyorinense from clinical specimens in Brazil2012

    • Author(s)
      Campos CE , Caldas PC, Ohnishi H, Watanabe T, Ohtsuka K, Matsushima S, Ferreira NV, da Silva MV, Redner P, de Carvalho LD, Medeiros RF, Abbud Filho JA , Montes FC, Galvao TC, Ramos JP
    • Journal Title

      Jounal of Clinical Microbiology

      Volume: 50 Issue: 7 Pages: 2477-2478

    • DOI

      10.1128/jcm.00023-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590688
  • [Presentation] 採血時静脈怒張手技が血液検査へ与える影響についての研究2023

    • Author(s)
      坂井 範子, 山崎 聡子, 米山 里香, 関口 久美子, 宮城 博幸, 大塚 弘毅, 安戸 裕貴, 大西 宏明
    • Organizer
      第70回日本臨床検査医学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07860
  • [Presentation] rad50変異メダカにおける紫外線(UVA)曝露による短命化メカニズムの解明2023

    • Author(s)
      大塚弘毅、苣田慎一、 藤原正親、松島早月、菊地茉莉 、小倉航、山﨑聡子、安戸裕貴、岸野智則、吉田正雄、苅田香苗、渡邊卓、大西宏明
    • Organizer
      日本臨床検査医学会総会
    • Data Source
      KAKENHI-PROJECT-20K08992
  • [Presentation] Rad50変異を有する毛細血管拡張性運動失調症(A-T)モデルメダカの作製(2):腫瘍原性の解析2022

    • Author(s)
      大塚弘毅
    • Organizer
      第69回日本臨床検査医学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K08992
  • [Presentation] Germline RAD50 I505fs loss-of-function variant detected in a gastrointestinal double primary cancer case with a family history of cancer2022

    • Author(s)
      Kouki Ohtsuka
    • Organizer
      The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine(ASCPaLM
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08992
  • [Presentation] RAD50機能喪失変異による発癌性を検証するメダカ発癌実験2021

    • Author(s)
      大塚弘毅
    • Organizer
      日本臨床検査医学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K08992
  • [Presentation] RAD50 Germline Variantを有する家族性癌、消化管重複癌の一例2020

    • Author(s)
      大塚弘毅
    • Organizer
      日本臨床検査医学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K08992
  • [Presentation] RAD50 Germline Variantを有する家族性癌、消化管重複癌の一例2020

    • Author(s)
      大塚弘毅
    • Organizer
      日本臨床検査医学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10799
  • [Presentation] 野生型マウスにおける自然発生がんの検討2019

    • Author(s)
      大塚弘毅
    • Organizer
      日本臨床検査医学会総会
    • Data Source
      KAKENHI-PROJECT-17K10799
  • [Presentation] Whole genome sequencing of family members with the germline EGFR V843I mutation predisposed to lung adenocarcinoma.2017

    • Author(s)
      Kouki Ohtsuka, Satoko Yamasaki, Satsuki Matsushima, Tomonori Kishino, Hiroaki Ohnishi, Takashi Watanabe
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08652
  • [Presentation] 非小細胞肺癌症例における全ゲノム増幅を用いたEGFR遺伝子変異検査の有用性の検討2017

    • Author(s)
      小倉航、大塚弘毅、藤原正親、田中良太、横山琢磨、高木靖志、大西宏明、渡邊卓
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K08652
  • [Presentation] Mycobacterium Kyorinense infection; Clinical, biological and genetic feature.2017

    • Author(s)
      Hiroaki Ohnishi, Kouki Ohtsuka, Yuko Kazumi, Takemasa Takii, Satoshi Mitarai, Satsuki Matsushima, Shota Yoneyama, Satoshi Otani, Takashi Yoshiyama, Yasuhiro Kato, Yata Hayashi, Junishi Machiya, Kaneyuki Kida, Jun Sugihara, Satoko Yamasaki, Tomonori Kishino, Hajime Goto, Takashi Watanabe
    • Organizer
      The 29th World congress of world association of societies of pathology and laboratory medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460686
  • [Presentation] Whole genome sequencing of family members with the germline EGFR V843i mutation predisposed to lung adenocarcinoma2017

    • Author(s)
      Kouki Ohtsuka
    • Organizer
      WASPaLM 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10799
  • [Presentation] Genetic Mechanism underlying drug resistance in Mycobacterium kyorinense and Mycobacterium celatum2016

    • Author(s)
      Hiroaki Ohnishi, Kouki Ohtsuka, Satsuki Matsushima, Eriko Nozaki, Shota Yonetani, Satoko Yamasaki, Tomonori Kishino, Takashi Watanabe
    • Organizer
      The 32nd World Congress of Biomedical Laboratory Science
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2016-08-31
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460686
  • [Presentation] EGFR V843I germline 変異をもつ遺伝性肺癌症例におけるWhole Genome Sequencing解析2016

    • Author(s)
      大塚弘毅
    • Organizer
      日本臨床検査医学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2016-09-01
    • Data Source
      KAKENHI-PROJECT-26462133
  • [Presentation] Mycobacterium kyorinenseおよびその近縁種の遺伝子解析2013

    • Author(s)
      大西宏明、松島早月、大塚弘毅、米谷正太、荒木光二、岸野智則、渡邊卓
    • Organizer
      日本臨床検査医学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23590688
  • [Presentation] JAK2 SPLICING MUTATION IN SIBLINGS PRESENTING WITH MYELOPROLIFERATIVE NEOPLASMS, CARDIOMYOPATHY AND HYPOGONADISM2011

    • Author(s)
      Hiroaki Ohnishi, Ken-ichirou Hosoi, Hiroshi Yoshino, Yuki Gemma, Kouki Ohtsuka, Satsuki Matsushima, Fumio Bessho, Takashi Watanabe, Fujino Takashi
    • Organizer
      43th Congress of the International Society of Paediatric Oncology
    • Place of Presentation
      Auckland, New Zealand
    • Data Source
      KAKENHI-PROJECT-23591550
  • [Presentation] 遺伝性骨髄増殖性腫瘍の家族例における網羅的遺伝子解析

    • Author(s)
      大西 宏明, 滝田 順子, 松島 早月, 大塚 弘毅, 岸野 智則, 細井 健一郎, 大倉 康夫, 小川 誠司, 渡邊 卓
    • Organizer
      日本臨床検査医学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-22 – 2014-11-25
    • Data Source
      KAKENHI-PROJECT-23591550
  • 1.  OHNISHI Hiroaki (80291326)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 16 results
  • 2.  WATANABE Takashi (00191768)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 13 results
  • 3.  MATSUSHIMA Satsuki (80231596)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 9 results
  • 4.  藤原 正親 (20407026)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  横山 琢磨 (50439197)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  広川 貴次 (20357867)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  中村 浩之 (30274434)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  田中 良太 (40415063)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  苣田 慎一 (90639791)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  山崎 聡子 (90782863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MORI Hideaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  岸野 智則
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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