Otsuka Kouki 大塚弘毅

… Alternative Names

OHTSUKA Kouki 大塚弘毅

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Researcher Number	70439165
Affiliation (Current)	2025: 杏林大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2023: 杏林大学, 医学部, 講師 2017 – 2023: 杏林大学, 医学部, 学内講師 2011 – 2016: 杏林大学, 医学部, 助教 2014: 杏林大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Respiratory surgery / Basic Section 55010:General surgery and pediatric surgery-related Except Principal Investigator Laboratory medicine / Basic Section 52010:General internal medicine-related / Pediatrics
Keywords	Principal Investigator 重複癌 / ゲノム編集 / メダカ / 発がん実験 / in vivo発がん実験 / Germline変異 / germline変異 / 発がんリスク / 次世代シーケンス / 生殖細胞系遺伝子変異（Germline変異） … More / がんゲノム医療 / 家族性がん / 重複がん / 毛細血管拡張性運動失調症 / ゲノム不安定性疾患 / メダカ発がん実験 / RAD50 I505fs germline変異 / 遺伝性腫瘍 / 家族性癌 / 予防 / ataxia-telangiectasia / RAD50 / ゲノム不安定性 / メダカ実験 / NGSパネル / がん関連遺伝子 / 多発癌 / 肺癌 / 家族性肺がん / 付加変異 / TP53 R248W / EGFR L858R / EGFR V843I / 遺伝性肺癌 / 家族性肺癌 / 先制医療 / 早期発見早期治療 / 予後予測 / TP53変異 / EGFR germline変異 / 肺がん / 分子シミュレーション / プロテオミクス / 遺伝子変異導入細胞 / 遺伝子改変マウス / 全ゲノムシーケンス / 遺伝性肺癌症候群 / EGFR V843I germline変異 … More Except Principal Investigator 全ゲノム解析 / 非結核性抗酸菌 / プレアナリティカル / 皮膚消毒 / 神経損傷 / 標準採血法 / 検体保存 / 採血 / 採血法 / 測定値への影響 / マッサージ / 温罨法 / 血管怒張 / 静脈採血 / 分子動態モデリング / 分子動力学モデル / チロシンキナーゼ阻害薬 / 動的立体構造解析 / 動的分子シミュレーション / 肺癌 / チロシンキナーゼ阻害剤 / EGFR / 質量分析 / 先天異常 / ＪＡＫ２ / DGKK / 先天性骨髄増殖性腫瘍 / スプライシング / GATA1 / 骨髄増殖性腫瘍 / スプライシング異常 / JAK2 / 同定不能菌 / 非定型抗酸菌 / Mycobacterium kyorinense / rpoB / 薬剤耐性 / mycobacterium celatum / mycobacterium kyorinense / 新菌種 / 感受性 / 遺伝子 / 抗酸菌 / 微生物 Less

Accumulation of comprehensive evidences to promote standardization of phlebotomy
- Principal Investigator
  
  大西宏明
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kyorin University
発がんリスクと考えられるGermline遺伝子変異によるin vivo発がん実験Principal Investigator
- Principal Investigator
  
  大塚弘毅
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyorin University
fundamental research for the development of germline mutation diagnosis enabling preemptive medicine for lung cancerPrincipal Investigator
- Principal Investigator
  
  Ohtsuka Kouki
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyorin University
Construction of dynamic prediction model of EGFR tyrosine kinase inhibitors efficacy for mutated EGFR based on protein three-dimensional structure analysis
- Principal Investigator
  
  Ohnishi Hiroaki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyorin University
Development of novel classification of mycobacteria by whole genome analysis and mass spectrometry
- Principal Investigator
  
  Matsushima Satsuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyorin University
Clinical and molecular biological study of hereditary lung cancer caused by EGFR germline mutationPrincipal Investigator
- Principal Investigator
  
  Ohtsuka Kouki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyorin University
Identification of novel non-tuberculous mycobacterium and analysis of the mechanism underlying its resistance to antibiotics
- Principal Investigator
  
  MATSUSHIMA Satsuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyorin University
Genetic analysis of a new syndrome with aberrant JAK2 splicing
- Principal Investigator
  
  OHNISHI Hiroaki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyorin University

All 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model2023
- Author(s)
  Chisada Shinichi、Ohtsuka Kouki、Fujiwara Masachika、Yoshida Masao、Matsushima Satsuki、Watanabe Takashi、Karita Kanae、Ohnishi Hiroaki
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 4 Pages: e0282277-e0282277
- DOI
  10.1371/journal.pone.0282277
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08992, KAKENHI-PROJECT-23K09656, KAKENHI-PROJECT-23K09697
[Journal Article] Next-Generation Sequencing for Non-Ampullary Duodenal Carcinoma Suggesting the Existence of an Adenoma-Carcinoma Sequence2021
- Author(s)
  Yoshida T, Kojima Y, Shimada R, Tanabe H, Tabei K, Yanagida O, Nikaido T, Ohtsuka K, Ohnishi H, Abe N, Hisamatsu T, Takahashi S
- Journal Title
  
  Case Rep Gastroenterol
  
  Volume: 15 Issue: 1 Pages: 62-69
- DOI
  10.1159/000510919
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08992
[Journal Article] Subtyping and EGFR mutation testing from blocks of cytological materials, based on liquid-based cytology for lung cancer at bronchoscopic examinations2020
- Author(s)
  Ryota Tanaka, Kouki Ohtsuka
- Journal Title
  
  Diagn Cytopathol
  
  Volume: 48(6) Issue: 6 Pages: 516-523
- DOI
  10.1002/dc.24397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08992
[Journal Article] Use of a plasma test for verifying epidermal growth factor receptor gene2020
- Author(s)
  Ogura W, Ohtsuka K
- Journal Title
  
  Respir Med Case Rep
  
  Volume: ? Pages: 101007-101007
- DOI
  10.1016/j.rmcr.2020.101007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10799
[Journal Article] STK11 p.F354L Germline Mutation in a Case of Multiple Gastrointestinal Tumors2020
- Author(s)
  Yohei Kojima, Kouki Ohtsuka
- Journal Title
  
  Case Rep Gastroenterol
  
  Volume: 14(3) Issue: 3 Pages: 547-553
- DOI
  10.1159/000508929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08992
[Journal Article] Predisposition to lung adenocarcinoma in a family harboring the germline EGFR V843I mutation.2019
- Author(s)
  Ohtsuka K, Ohnishi H, Fujiwara M, Morii T, Matsushima S, Ogura W, Yamasaki S, Kishino T, Tanaka R, Watanabe T
- Journal Title
  
  JCO Precision Oncology
  
  Volume: - Issue: 3 Pages: 1-4
- DOI
  10.1200/po.19.00104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01439, KAKENHI-PROJECT-17K10799
[Journal Article] APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.2018
- Author(s)
  Kojima Y, Ohtsuka K, Ohnishi H, Abe N, Furuse J, Watanabe T, Sugiyama M.
- Journal Title
  
  Surg
  
  Volume: 48(8) Issue: 8 Pages: 765-772
- DOI
  10.1007/s00595-018-1649-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10799
[Journal Article] Whole-Genome Sequence of Mycobacterium kyorinense2014
- Author(s)
  Ohtsuka K, Ohnishi H, Nozaki E, Matsushima S, et al.
- Journal Title
  
  Genome Announcements
  
  Volume: 2 Issue: 5
- DOI
  10.1128/genomea.01062-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590688, KAKENHI-PROJECT-24390106, KAKENHI-PROJECT-26460686
[Journal Article] Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense2014
- Author(s)
  Hiroaki Ohnishi, Enrico Tortoli, Jesus Pais Ramos, Yuko Kazumi, Shota Yonetani, Satsuki Matsushima, Kouki Ohtsuka and Takashi Watanabe
- Journal Title
  
  Ａｎｎａｌｓ　ｏｆ　Ｍｉｃｒｏｂｉｏｌｏｇｙ
  
  Volume: 未定 Issue: 4 Pages: 1879-1882
- DOI
  10.1007/s13213-014-0860-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590688
[Journal Article] Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense2014
- Author(s)
  Ohnishi H, Tortoli E, Ramos JP, Kazumi Y, Yonetani S, Matsushima S, Ohtsuka K, Watanabe T
- Journal Title
  
  Annals of Microbiology
  
  Volume: 64 Pages: 1879-1882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590688
[Journal Article] First isolation of Mycobacterium kyorinense from clinical specimens in Brazil2012
- Author(s)
  Campos CE , Caldas PC, Ohnishi H, Watanabe T, Ohtsuka K, Matsushima S, Ferreira NV, da Silva MV, Redner P, de Carvalho LD, Medeiros RF, Abbud Filho JA , Montes FC, Galvao TC, Ramos JP
- Journal Title
  
  Jounal of Clinical Microbiology
  
  Volume: 50 Issue: 7 Pages: 2477-2478
- DOI
  10.1128/jcm.00023-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590688
[Presentation] 採血時静脈怒張手技が血液検査へ与える影響についての研究2023
- Author(s)
  坂井範子, 山崎聡子, 米山里香, 関口久美子, 宮城博幸, 大塚弘毅, 安戸裕貴, 大西宏明
- Organizer
  第70回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07860
[Presentation] rad50変異メダカにおける紫外線（UVA）曝露による短命化メカニズムの解明2023
- Author(s)
  大塚弘毅、苣田慎一、藤原正親、松島早月、菊地茉莉、小倉航、山﨑聡子、安戸裕貴、岸野智則、吉田正雄、苅田香苗、渡邊卓、大西宏明
- Organizer
  日本臨床検査医学会総会
- Data Source
  KAKENHI-PROJECT-20K08992
[Presentation] Rad50変異を有する毛細血管拡張性運動失調症(A-T)モデルメダカの作製（２）：腫瘍原性の解析2022
- Author(s)
  大塚弘毅
- Organizer
  第69回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08992
[Presentation] Germline RAD50 I505fs loss-of-function variant detected in a gastrointestinal double primary cancer case with a family history of cancer2022
- Author(s)
  Kouki Ohtsuka
- Organizer
  The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine（ASCPaLM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08992
[Presentation] RAD50機能喪失変異による発癌性を検証するメダカ発癌実験2021
- Author(s)
  大塚弘毅
- Organizer
  日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08992
[Presentation] RAD50 Germline Variantを有する家族性癌、消化管重複癌の一例2020
- Author(s)
  大塚弘毅
- Organizer
  日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08992
[Presentation] RAD50 Germline Variantを有する家族性癌、消化管重複癌の一例2020
- Author(s)
  大塚弘毅
- Organizer
  日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10799
[Presentation] 野生型マウスにおける自然発生がんの検討2019
- Author(s)
  大塚弘毅
- Organizer
  日本臨床検査医学会総会
- Data Source
  KAKENHI-PROJECT-17K10799
[Presentation] Whole genome sequencing of family members with the germline EGFR V843I mutation predisposed to lung adenocarcinoma.2017
- Author(s)
  Kouki Ohtsuka, Satoko Yamasaki, Satsuki Matsushima, Tomonori Kishino, Hiroaki Ohnishi, Takashi Watanabe
- Organizer
  The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08652
[Presentation] 非小細胞肺癌症例における全ゲノム増幅を用いたEGFR遺伝子変異検査の有用性の検討2017
- Author(s)
  小倉航、大塚弘毅、藤原正親、田中良太、横山琢磨、高木靖志、大西宏明、渡邊卓
- Organizer
  第64回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08652
[Presentation] Mycobacterium Kyorinense infection; Clinical, biological and genetic feature.2017
- Author(s)
  Hiroaki Ohnishi, Kouki Ohtsuka, Yuko Kazumi, Takemasa Takii, Satoshi Mitarai, Satsuki Matsushima, Shota Yoneyama, Satoshi Otani, Takashi Yoshiyama, Yasuhiro Kato, Yata Hayashi, Junishi Machiya, Kaneyuki Kida, Jun Sugihara, Satoko Yamasaki, Tomonori Kishino, Hajime Goto, Takashi Watanabe
- Organizer
  The 29th World congress of world association of societies of pathology and laboratory medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460686
[Presentation] Whole genome sequencing of family members with the germline EGFR V843i mutation predisposed to lung adenocarcinoma2017
- Author(s)
  Kouki Ohtsuka
- Organizer
  WASPaLM　2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10799
[Presentation] Genetic Mechanism underlying drug resistance in Mycobacterium kyorinense and Mycobacterium celatum2016
- Author(s)
  Hiroaki Ohnishi, Kouki Ohtsuka, Satsuki Matsushima, Eriko Nozaki, Shota Yonetani, Satoko Yamasaki, Tomonori Kishino, Takashi Watanabe
- Organizer
  The 32nd World Congress of Biomedical Laboratory Science
- Place of Presentation
  Kobe, Japan
- Year and Date
  2016-08-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460686
[Presentation] EGFR V843I germline 変異をもつ遺伝性肺癌症例におけるWhole Genome Sequencing解析2016
- Author(s)
  大塚弘毅
- Organizer
  日本臨床検査医学会総会
- Place of Presentation
  神戸
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-26462133
[Presentation] Mycobacterium kyorinenseおよびその近縁種の遺伝子解析2013
- Author(s)
  大西宏明、松島早月、大塚弘毅、米谷正太、荒木光二、岸野智則、渡邊卓
- Organizer
  日本臨床検査医学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590688
[Presentation] JAK2 SPLICING MUTATION IN SIBLINGS PRESENTING WITH MYELOPROLIFERATIVE NEOPLASMS, CARDIOMYOPATHY AND HYPOGONADISM2011
- Author(s)
  Hiroaki Ohnishi, Ken-ichirou Hosoi, Hiroshi Yoshino, Yuki Gemma, Kouki Ohtsuka, Satsuki Matsushima, Fumio Bessho, Takashi Watanabe,　Fujino Takashi
- Organizer
  43th Congress of the International Society of Paediatric Oncology
- Place of Presentation
  Auckland, New Zealand
- Data Source
  KAKENHI-PROJECT-23591550
[Presentation] 遺伝性骨髄増殖性腫瘍の家族例における網羅的遺伝子解析
- Author(s)
  大西宏明, 滝田順子, 松島早月, 大塚弘毅, 岸野智則, 細井健一郎, 大倉康夫, 小川誠司, 渡邊卓
- Organizer
  日本臨床検査医学会
- Place of Presentation
  福岡
- Year and Date
  2014-11-22 – 2014-11-25
- Data Source
  KAKENHI-PROJECT-23591550

1. OHNISHI Hiroaki (80291326)

# of Collaborated Projects: 8 results

# of Collaborated Products: 16 results
2. WATANABE Takashi (00191768)

# of Collaborated Projects: 8 results

# of Collaborated Products: 13 results
3. MATSUSHIMA Satsuki (80231596)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
4. 藤原正親 (20407026)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 横山琢磨 (50439197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 広川貴次 (20357867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中村浩之 (30274434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田中良太 (40415063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 苣田慎一 (90639791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 山崎聡子 (90782863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MORI Hideaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 岸野智則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Otsuka Kouki 大塚 弘毅

OHTSUKA Kouki 大塚 弘毅

Research Projects

Research Products

Co-Researchers

Accumulation of comprehensive evidences to promote standardization of phlebotomy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

発がんリスクと考えられるGermline遺伝子変異によるin vivo発がん実験Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

fundamental research for the development of germline mutation diagnosis enabling preemptive medicine for lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Construction of dynamic prediction model of EGFR tyrosine kinase inhibitors efficacy for mutated EGFR based on protein three-dimensional structure analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel classification of mycobacteria by whole genome analysis and mass spectrometry

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical and molecular biological study of hereditary lung cancer caused by EGFR germline mutationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of novel non-tuberculous mycobacterium and analysis of the mechanism underlying its resistance to antibiotics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic analysis of a new syndrome with aberrant JAK2 splicing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Next-Generation Sequencing for Non-Ampullary Duodenal Carcinoma Suggesting the Existence of an Adenoma-Carcinoma Sequence2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Subtyping and EGFR mutation testing from blocks of cytological materials, based on liquid-based cytology for lung cancer at bronchoscopic examinations2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Use of a plasma test for verifying epidermal growth factor receptor gene2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] STK11 p.F354L Germline Mutation in a Case of Multiple Gastrointestinal Tumors2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predisposition to lung adenocarcinoma in a family harboring the germline EGFR V843I mutation.2019

Author(s)

Otsuka Kouki 大塚弘毅

OHTSUKA Kouki 大塚弘毅