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Ogawa Tomohiro  小川 智弘

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OGAWA Tomohiro  小川 智弘

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Researcher Number 70448752
Affiliation (Current) 2025: 近畿大学, 工学部, 准教授
Affiliation (based on the past Project Information) *help 2014 – 2015: 近畿大学, 工学部, 講師
2011: 大阪市立大学, 大学院・医学研究科, 博士研究員
2011: 近畿大学, 工学部, 助教
2010: 大阪市立大学, 大学院・医学研究科, ポスドク研究員
2009 – 2010: 大阪市立大学, 大学院・医学研究科, 研究員
Review Section/Research Field
Principal Investigator
General anatomy (including histology/embryology) / Gastroenterology
Except Principal Investigator
Carcinogenesis / Gastroenterology
Keywords
Principal Investigator
コラーゲン / 肝臓 / 星細胞 / 線維化 / オステオポンチン / インテグリン / マイクロRNA
Except Principal Investigator
ビタミンA / 線維芽細胞 / サイトグロビン … More / 間質細胞 / 自然発症 / 乳癌 / ジエチルニトロサミン / サイトグロイン / ジェチルニトロサミン / 動物モデル / 肝癌 / 肝硬変 Less
  • Research Projects

    (4 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (7 People)
  •  Study on the molecular mechanisms of fibrogenesis by myofibroblasts which accumulate around fibersPrincipal Investigator

    • Principal Investigator
      OGAWA Tomohiro
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General anatomy (including histology/embryology)
    • Research Institution
      Kinki University
  •  Involvement of cytoglobin-expressing mesenchymal cells in cancer development

    • Principal Investigator
      KAWADA Norifumi
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Carcinogenesis
    • Research Institution
      Osaka City University
  •  Development of liver fibrosis therapy targeting hepatic stellate cells by microRNAPrincipal Investigator

    • Principal Investigator
      OGAWA Tomohiro
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kinki University
      Osaka City University
  •  Analyses of the development of liver cancer and cirrhosis by using cytoglobin-deficient mice

    • Principal Investigator
      KAWADA Norifumi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka City University

All 2015 2012 2011 2010

All Journal Article Presentation Patent

  • [Journal Article] MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis.2012

    • Author(s)
      Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N.
    • Journal Title

      Gut

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-21390232
  • [Journal Article] MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis2012

    • Author(s)
      Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N
    • Journal Title

      Gut

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-22650224
  • [Journal Article] MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis2012

    • Author(s)
      小川智弘
    • Journal Title

      Gut

      Volume: (掲載確定) Issue: 11 Pages: 1600-1609

    • DOI

      10.1136/gutjnl-2011-300717

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Journal Article] microRNA-221/222 up-regulation indicates the activation of stellate cells and the progression of liver fibrosis2012

    • Author(s)
      Ogawa T, Enomoto M, Fujii H他4名
    • Journal Title

      Gut

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Journal Article] Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation2011

    • Author(s)
      Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N.
    • Journal Title

      J Cell Physiol

      Volume: 226 Pages: 2535-42

    • Data Source
      KAKENHI-PROJECT-21390232
  • [Journal Article] Down-regulation of cyclin E1 expression by microrna-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation2011

    • Author(s)
      Sekiya Y, Ogawa T, Iizuka M他3名
    • Journal Title

      J Cell Physiol

      Volume: 226(10) Pages: 2535-2542

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Journal Article] Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice. Thuy le TT2011

    • Author(s)
      Morita T, Yoshida K, Wakasa K, Iizuka M, Ogawa T, Mori M, Sekiya Y, Momen S, Motoyama H, Ikeda K, Yoshizato K, Kawada N.
    • Journal Title

      Am J Pathol

      Volume: 179 Pages: 1050-60

    • Data Source
      KAKENHI-PROJECT-22650224
  • [Journal Article] Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice. Thuy le TT2011

    • Author(s)
      Morita T, Yoshida K, Wakasa K, Iizuka M, Ogawa T, Mori M, Sekiya Y, Momen S, Motoyama H, Ikeda K, Yoshizato K, Kawada N.
    • Journal Title

      Am J Pathol

      Volume: 179 Pages: 1050-60

    • Data Source
      KAKENHI-PROJECT-21390232
  • [Journal Article] Suppression of hepatic stellate cell activation by microRNA-29b2011

    • Author(s)
      Sekiya Y, Ogawa T, Yoshizato K他2名
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 412(1) Pages: 74-79

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Journal Article] Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation2011

    • Author(s)
      Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N.
    • Journal Title

      J Cell Physiol

      Volume: 226 Pages: 2535-42

    • Data Source
      KAKENHI-PROJECT-22650224
  • [Journal Article] Suppression of type I collagen production by microRNA-29b in cultured human stellate cells.2010

    • Author(s)
      Ogawa T, Iizuka M, et al.
    • Journal Title

      Biochem Biophys Res Commun. 391

      Pages: 316-321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390232
  • [Journal Article] A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbits.2010

    • Author(s)
      Ogawa T, Fujii H, et al.
    • Journal Title

      Am J Pathol.

      Volume: 177 Pages: 153-165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650224
  • [Journal Article] A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbits2010

    • Author(s)
      Ogawa T, Fujii H, Yoshizato K, Kawada N.
    • Journal Title

      Am J Pathol

      Volume: 177 Pages: 153-65

    • Data Source
      KAKENHI-PROJECT-22650224
  • [Journal Article] Down-regulation of cyclin El expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation.2010

    • Author(s)
      Sekiya Y, Ogawa T, et al.
    • Journal Title

      J Cell Physiol.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650224
  • [Journal Article] A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbits.2010

    • Author(s)
      Ogawa T, Fujii H, et al.
    • Journal Title

      Am J Pathol.

      Volume: 177 Pages: 153-165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390232
  • [Journal Article] Suppression of type I collagen production by microRNA-29b in cultured human stellate cells2010

    • Author(s)
      Ogawa T, Iizuka M, Sekiya Y他3名
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 391(1) Pages: 316-321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Journal Article] Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation.2010

    • Author(s)
      Sekiya Y, Ogawa T, et al.
    • Journal Title

      J Cell Physiol.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390232
  • [Journal Article] A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbits2010

    • Author(s)
      Ogawa T, Fujii H, Yoshizato K, Kawada N
    • Journal Title

      Am J Pathol

      Volume: 177 Pages: 153-65

    • Data Source
      KAKENHI-PROJECT-21390232
  • [Journal Article] Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet.2010

    • Author(s)
      Mu YP, Ogawa T, Kawada N.
    • Journal Title

      Lab Invest. 90

      Pages: 245-256

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390232
  • [Patent] 肝線維症の存在及び/又は肝線維症の重症度の判定方法、判定マーカー、判定用キット、肝線維症の治療の効果予測方法、効果予測マーカー、並びに効果予測用キット2010

    • Inventor(s)
      河田則文、榎本大、小川智弘
    • Industrial Property Rights Holder
      公立大学法人大阪市立大学
    • Industrial Property Number
      2010-281254
    • Filing Date
      2010-12-17
    • Data Source
      KAKENHI-PROJECT-22650224
  • [Patent] 肝線維症の存在及び/又は肝線維症の重症度の判定方法、判定マーカー、判定用キット、肝線維症の治療の効果予測方法、効果予測マーカー、並びに効果予測用キット2010

    • Inventor(s)
      河田則文、榎本大、小川智弘
    • Industrial Property Rights Holder
      公立大学法人大阪市立大学
    • Industrial Property Number
      2010-281254
    • Filing Date
      2010-12-17
    • Data Source
      KAKENHI-PROJECT-21390232
  • [Patent] 肝線維症の存在及び/又は肝線維症の重症度の判定方法、判定マーカー、判定用キット、肝線維症の治療の効果予測方法、効果予測マーカー、並びに効果予測用キット2010

    • Inventor(s)
      河田則文、榎本大、小川智弘
    • Industrial Property Rights Holder
      大阪市立大学
    • Industrial Property Number
      2010-281254
    • Filing Date
      2010-12-17
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] Propolis components suppresses activated hepatic stellate cell invasion by inhibition of MMP-2 and MMP-9 expression and its activation2015

    • Author(s)
      小川智弘
    • Organizer
      第18回国際類洞壁細胞シンポジウム
    • Place of Presentation
      アメリカ(パシフィックグローブ)
    • Year and Date
      2015-11-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860140
  • [Presentation] マイクロRNAの肝線維化診断マーカーとしての有用性とその機能2012

    • Author(s)
      小川智弘
    • Organizer
      Kansai Liver Club 2012
    • Place of Presentation
      太閤園(大阪)
    • Year and Date
      2012-03-03
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] マイクロRNAの肝線維化診断マーカーとしての有用性とその機能2012

    • Author(s)
      小川智弘、榎本大、藤井英樹, 他3名
    • Organizer
      Kansai Liver Club2012
    • Place of Presentation
      太閤園(大阪)
    • Year and Date
      2012-03-03
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] 慢性肝疾患における肝線維化バイオマーカーとしてのマイクロRNAの有用性2011

    • Author(s)
      榎本大、小川智弘、河田則文
    • Organizer
      第39回日本肝臓学会西部会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2011-12-09
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] 肝線維化と星細胞活性化に関与するマイクロRNAの解析2011

    • Author(s)
      飯塚昌司、小川智弘、関谷由美子, 他4名
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Year and Date
      2011-10-20
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] 肝線維化と星細胞活性化に関与するマイクロRNAの解析2011

    • Author(s)
      飯塚昌司、榎本大、吉里勝利、小川智弘, 他2名
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス(東京)
    • Year and Date
      2011-06-24
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] C型慢性肝炎患者における肝線維化診断マーカーとしてのマイクロRNAの有用性2011

    • Author(s)
      小川智弘
    • Organizer
      第97回日本消化器病学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-05-13
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] 慢性肝疾患における肝線維化バイオマーカーとしてのマイクロRNAの有用性2011

    • Author(s)
      飯塚昌司、小川智弘、榎本大, 他3名
    • Organizer
      第23回肝類洞壁細胞研究会学術集会
    • Place of Presentation
      東京ガーデンパレス(東京)
    • Year and Date
      2011-12-17
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] miR-195の肝星細胞増殖における役割についての検討2011

    • Author(s)
      関谷由美子、小川智弘、飯塚昌司, 他3名
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA(東京)
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] Indication of the Activation of Stellate Cells and the Progression of Liver Fibrosis by MicroRNA-2222011

    • Author(s)
      榎本大、小川智弘、飯塚昌司, 他5名
    • Organizer
      62nd Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Center(アメリカ)
    • Year and Date
      2011-11-06
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] 慢性肝疾患における肝線維化バイオマーカーとしてのmiR-222の有用性2011

    • Author(s)
      飯塚昌司、榎本大、小川智弘, 他6名
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Year and Date
      2011-10-20
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] C型慢性肝炎患者における肝線維化診断マーカーとしてのマイクロRNAの有用性2011

    • Author(s)
      小川智弘、榎本大、河田則文
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-05-13
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] Type I interferon inhibits hepatic stellate cell proliferation via downregulation of cyclin E1 by microRNA-1952010

    • Author(s)
      関谷由美子、小川智弘、飯塚昌司, 他3名
    • Organizer
      15th International Symposium on Cells of the Hepatic Sinusoid
    • Place of Presentation
      Hilton Hotel Pasadena(アメリカ)
    • Year and Date
      2010-08-31
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] 星細胞活性化に関与するマイクロRNAについての検討2010

    • Author(s)
      関谷由美子、小川智弘、飯塚昌司, 他3名
    • Organizer
      第6回広島肝臓プロジェクト研究センターシンポジウム
    • Place of Presentation
      ホテルグランヴィア広島(広島)
    • Year and Date
      2010-06-04
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] マイクロRNAによる肝星細胞のI型コラーゲン発現制御2010

    • Author(s)
      飯塚昌司、小川智弘、関谷由美子, 他3名
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形国際ホテル(山形)
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] MICRORNA-29B SUPPRESSES TYPE I COLLAGEN AND SP1 EXPRESSION IN INTERFERON-TREATED STELLATE CELLS2010

    • Author(s)
      小川智弘、飯塚昌司、関谷由美子, 他3名
    • Organizer
      45th annual meeting of the European Association for the Study of the Liver
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2010-04-17
    • Data Source
      KAKENHI-PROJECT-22790666
  • [Presentation] I型インターフェロンのマイクロRNA発現調節を介した肝星細胞増殖抑制作用2010

    • Author(s)
      関谷由美子、小川智弘、飯塚昌司, 他3名
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形国際ホテル(山形)
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22790666
  • 1.  KAWADA Norifumi (30271191)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 2.  MORITA Takashi (70150349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  TAMORI Akihiro (30291595)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  ENOMOTO Masaru (20423874)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  LE Thuy (10572175)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MOTOYAMA Hiroyuki (00573601)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  志賀 亮子 (50382221)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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