KAWADA Norifumi 河田則文

… Alternative Names

Researcher Number	30271191
Other IDs
External Links
Affiliation (Current)	2022: 大阪公立大学, 大学院医学研究科, 教授
Affiliation (based on the past Project Information) *help	2022: 大阪公立大学, 大学院医学研究科, 教授 2015 – 2021: 大阪市立大学, 大学院医学研究科, 教授 2011 – 2014: 大阪市立大学, 医学(系)研究科(研究院), 教授 2013: 大阪市立大学, 医学研究院, 教授 2009 – 2011: Osaka City University, 大学院・医学研究科, 教授 … More
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology / Basic Section 53010:Gastroenterology-related / Carcinogenesis / Biological Sciences Except Principal Investigator General surgery / Gastroenterology / Digestive surgery / Basic Section 53010:Gastroenterology-related / Digestive surgery … More
Keywords	Principal Investigator 星細胞 / サイトグロビン / 肝線維化 / 肝硬変 / 線維芽細胞 / 肝癌 / 動物モデル / 肝星細胞 / liver fibrosis / コラーゲン … More Except Principal Investigator 肝線維化 / 星細胞 / ROCK / 肝星細胞 / 肝不全 / NAC / 肝障害 / 肝微小循環 / 生体顕微鏡 / Rho kinase阻害剤 / 虚血再潅流障害 / hepatic microcirculation / Rho kinase inhibitor / 肝細胞 / 細胞外マトリックス / チオレドキシン / コラーゲン / マイクロRNA / Liver failure / Liver fibrosis / hepatic stellate cell / 抗酸化剤 / PDGFレセプター / カテプシン / 肝硬変 / 供培養 / 酸化ストレス / 術後肝障害 / 肝再生 / B型肝炎 / 細胞培養 / Hepatic Stellate Cell / 類洞 / エンドトキシン / Intravital microscopyu / Y-27632 / enndotoxin / ROCK阻害剤 / N-アセチルシステイン / 肝繊維化 / thioredoxin / ischemia / reperfusion injury / intravital microscopy / N-acetylcisteine / liver failure / DDR2 / Src / Shc / MMP-2 / collagen / liver fibrosis / Cre / loxP / synemin / vimentin / 胆管癌 / 印刷所労働者 / 遺伝子 / 線維化 / N-acetyl-cysteine / 増殖因子 / 細胞増殖 / DNA合成 / 細胞間相互作用 / トランスジェニックマウス / 低分子RNA / Cre-loP / C型慢性肝炎 / インターフェロン / リバビリン / 脂肪性肝炎 / 細胞死 / cytokeratin 18 fragment / 脂肪肝の脆弱性 / 組織修復 / B型慢性肝炎 / マクロファージ / 肝脂肪化 / MSR-A / MSr-A / 脂肪肝炎 / IV型コラーゲン / 共培養 / Liver Failure / liver Regeneration / Hepatocyte / Hepatic Extracellular Matrix / Type IV Collagen / Cell Culture / Liver Fibrosis / Anti-oxidant / PDGF receptor / Catepsin / Liver cirrhosis / 類洞壁細胞 / 肝切除 / 急性肝不全 / 肝腺維化 / stellate cells / 肝癌 / 急性期肝障害 / 慢性肝炎 / 肝細胞癌 / chemoprevention / Hepatic stellate cells / アデノウイルスベクター / 臓器線維症 / TGF-beta / BMP-7 / Id2 / Id3 / Stellate cells / adenoviral vector / サイトグロビン / ヘムタンパク質 / トランスジェニックガエル / 無脳症 / 神経管閉鎖不全 / 分子発生学 / 体外受精 / 頭部形成遺伝子 / cytoglobin / heme-protein / transgenic forg / anencephaly / neural tube disclosure / molecular embryogenesis / in vitro fertilization / head organizer genes / 中間系フィラメント / Intermediate filament / liver fibrois / hepatic stellate cells / hepatocellular carcinoma / 有機溶剤 / 癌抑制遺伝子 / mRNA / microRNA / SKI / p21 / 若年 / 遺伝子発現 / 印刷所 / 胆管細胞癌 / 若年胆管細胞癌 / 印刷会社 / 代謝酵素 / 遺伝子発現異常 / micro RNA / C型肝炎 / SVR / バイオマーカー / 内科 / 肝炎 / HCC SNP / 大阪市 / 癌遺伝子 / 創薬 / 非アルコール性脂肪肝炎 / DIF-1 / Cytoglobin / Promoter / Demethylation / liver tumor / pancreatic tumor / 免疫チェックポイント分子 Less

肝細胞のがん化における細胞間相互作用を介した星細胞の役割Principal Investigator
- Principal Investigator
  
  河田則文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Metropolitan University
Cytoglobin (CYGB)-overexpression and targeted demethylation of CYGB promoter impair liver and pancreatic tumor growth
- Principal Investigator
  
  HOANG HAI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka City University
B型肝炎の治療抵抗性および病態進展における免疫チェックポイント分子の関与
- Principal Investigator
  
  榎本大
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka City University
Basic study for developing NASH therapeutic drugs by using a small molecule derived from the cellular slime mold serving as a lead compound
- Principal Investigator
  
  石川智久
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Shizuoka
地元大阪の印刷所労働者胆管がん組織を使ったがん遺伝子の探索：創薬基盤の構築
- Principal Investigator
  
  川村悦史
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Osaka City University
活性化星細胞はサイトグロビンを介して肝細胞のがん化に直接的に関与するか？Principal Investigator
- Principal Investigator
  
  河田則文
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka City University
Development of anti-fibrotic therapy for liver disease by establishing technologies that regulate cytoglobin expression in hepatic stellate cellsPrincipal Investigator
- Principal Investigator
  
  KAWADA NORIFUMI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
MicroRNA as a biomarker for prediction of HCC development after achieving an SVR
- Principal Investigator
  
  Enomoto Masaru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
Genetic risk verification of juvenile-onset cholangiocarcinoma
- Principal Investigator
  
  Kawamura Etsushi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Osaka City University
Study on miRNA expression and single nucleotide polymorphisms in hepatocellular carcinoma after HCV eradication
- Principal Investigator
  
  HOANG HAI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
Involvement of Cytoglobin expressed in hepatic stellate cells in the development of cancer derived from inflamed liver.Principal Investigator
- Principal Investigator
  
  KAWADA NORIFUMI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
MicroRNA as a liver fibrosis marker in chronic hepatitis B
- Principal Investigator
  
  Enomoto Masaru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
Mechanism of formation of hepatic steatosis in Non-alcoholic fatty liver disease (NAFLD)
- Principal Investigator
  
  Hideki Fujii
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
癌微小環境形成におけるサイトグロビン陽性あるいは陰性筋線維芽細胞の役割Principal Investigator
- Principal Investigator
  
  河田則文
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
The ability of tisuue repair and regeneration in steatohepatitic liver
- Principal Investigator
  
  KAMOHARA Yukio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
Involvement of cytoglobin-expressing mesenchymal cells in cancer developmentPrincipal Investigator
- Principal Investigator
  
  KAWADA Norifumi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Carcinogenesis
- Research Institution
  Osaka City University
Analyses of the development of liver cancer and cirrhosis by using cytoglobin-deficient micePrincipal Investigator
- Principal Investigator
  
  KAWADA Norifumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
Intrahepatic microRNA expression and response to peginterferon-α and ribavirin therapy in patients with chronic hepatitis C
- Principal Investigator
  
  ENOMOTO Masaru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
変性赤血球による非アルコール性脂肪性肝炎病態の修飾Principal Investigator
- Principal Investigator
  
  河田則文
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
ShRNAライブラリーを用いた肝線維化,癌化関連因子の網羅的解析と治療への応用
- Principal Investigator
  
  IKEDA Kazuo
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka City University
The role of intermediateted filament proteins in hepatic stellate cells in the development of liver fibrosis and hepatocellular carcinoma
- Principal Investigator
  
  UYAMA Naoki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Hyogo College of Medicine
Molecular Mechanism for Anencephaly
- Principal Investigator
  
  OBARA Masanobu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  HIROSHIMA UNIVERSITY
Improvement of perioperative and postoperative management after hepatic resection for HCC by the regulation of hepatic stellate cells.
- Principal Investigator
  
  HATANO Etsuro, 嶌原康行
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Targeted and regulable expression of transgenes in hepatic stellate cells using an adenoviral Cre-loxP system
- Principal Investigator
  
  IKEDA Kazuo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Osaka City University
Functional analysis of cytoglobin that is expressed and induced in liver cirrhosisPrincipal Investigator
- Principal Investigator
  
  KAWADA Norifumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
ストレス応答蛋白チオレドキシンによる新しい術後肝障害防止対策
- Principal Investigator
  
  嶌原康行
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Development of perioperative management for hepatic resection based on the stellate cell function
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
The signal pthway and the role of the discoidin domain receptor 2 (DDR2) which is stimulated by type I collagen
- Principal Investigator
  
  IKEDA Kazuo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Osaka City University
Functional analysis of stap, a novel gene expressed in hepatic stellate cells and fibrotic liver tissue and its significance in clinicopathophysiologyPrincipal Investigator
- Principal Investigator
  
  KAWADA Norifumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
肝細胞・肝星細胞の供培養による細胞増殖相互作用
- Principal Investigator
  
  嶌原康行
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Regulation of hepatic micro circulation by hepatic stellate cell-Application of NAC to liver failure
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
N-acetylcysteineによる星細胞活性化の制御
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Strategy for Liver Failure by Regulating Hepatic Microcirculation through Hepatic Stellate Cell Activatity
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Aspect of Strategy for Liver Failure by Regelating Hepatic Stellate Cell Activation
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Pathophysiological Analysis of Prion Protein Expression in the LiverPrincipal Investigator
- Principal Investigator
  
  KAWADA Norifumi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
New Strategy for Liver Failure by Regulating Hepatic Extracellular Matrix
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
肝星細胞活性化の分子解析とそれを利用した肝線維化抑制法の開発Principal Investigator
- Principal Investigator
  
  河田則文
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University
肝類洞細胞に発現する特異蛋白のcDNAクローニングとその機能解析Principal Investigator
- Principal Investigator
  
  河田則文
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka City University

[Book] Liver Pathophysiology: Therapies and Antioxidants2017
- Author(s)
  Le Thi Thanh Thuy, Tuong Thi Van Thuy, Hoang Hai, and Norifumi Kawada
- Total Pages
  914
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26860522
[Book] 肝臓の線維化研究の進展2010
- Author(s)
  河田則文
- Total Pages
  7
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22650224
[Book] 肝臓の線維化研究の進展2010
- Author(s)
  河田則文
- Total Pages
  7
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] 肝星細胞の活性化の仕組み　サイトグロビンの作用から見えてくる新しい視点2019
- Author(s)
  松原三佐子, 河田則文, 吉里勝利
- Journal Title
  
  細胞
  
  Volume: 51 Pages: 530-534
- Data Source
  KAKENHI-PROJECT-19H03641
[Journal Article] Obesity and hiatal hernia may be non-allergic risk factors for esophageal eosinophilia in Japanese adults.2019
- Author(s)
  Tanaka F, Fukumoto S, Morisaki T, Otani K, Hosomi S, Nagami Y, Kamata N, Taira K, Nakano A, Kimura T, Yamagami H, Tanigawa T, Morikawa H, Watanabe T, Kawada N, Hirata K, Fujiwara Y.
- Journal Title
  
  Esophagus
  
  Volume: 16 Pages: 309-315
- DOI
  10.1007/s10388-019-00662-3
- NAID
  120006876362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07917, KAKENHI-PROJECT-19H03641
[Journal Article] 肝機能障害を契機に診断されたサルコイドーシス5例の検討2019
- Author(s)
  焦光裕、榎本大、小谷晃平、小田桐直志、吉田香奈子、元山宏行、小塚立蔵、藤井英樹、萩原淳司、打田佐和子、森川浩安、村上善基、田守昭博、河田則文
- Journal Title
  
  肝臓
  
  Volume: 60 Pages: 405-413
- NAID
  130007741895
- Data Source
  KAKENHI-PROJECT-19H03641
[Journal Article] HOMA-IR: An independent predictor of advanced liver fibrosis in nondiabetic non-alcoholic fatty liver disease2019
- Author(s)
  Fujii H, Yoneda M, et al.
- Journal Title
  
  J Gastroenterol Hepatol. 2019 Aug;34(8):1390-1395.
  
  Volume: in press Pages: 1390-1395
- DOI
  10.1111/jgh.14595
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07637, KAKENHI-PROJECT-17K15866, KAKENHI-PROJECT-17K09437, KAKENHI-PROJECT-19H03641, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09434
[Journal Article] Hepatitis C virus recurrence in two patients who achieved sustained viral response with interferon-free direct-acting antiviral therapy: reinfection or relapse?2019
- Author(s)
  Yukawa Y, Tamori A, Iio E, Ogawa S, Yoshida K, Uchida-Kobayashi S, Enomoto M, Tanaka Y, Kawada N.
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: 12 Pages: 598-602
- DOI
  10.1007/s12328-019-01001-w
- NAID
  120006866793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03641
[Journal Article] C型肝炎　HCV排除は肝がんを抑制するのか　外来でのフォローはどうするか2019
- Author(s)
  榎本大(大阪市立大学大学院医学研究科肝胆膵病態内科学), 伊倉義弘, 田守昭博, 河田則文
- Journal Title
  
  内科
  
  Volume: 123 Pages: 1081-1085
- Data Source
  KAKENHI-PROJECT-19H03641
[Journal Article] Interstitial pneumonia suspected during regorafenib administration and exacerbated by subsequent therapy with lenvatinib for unresectable hepatocellular carcinoma.2019
- Author(s)
  Kotani K, Enomoto M, Okada M, Yoshida K, Motoyama H, Fiji H, Hagihara A, Uchida-Kobayashi S, Mordkawa H, Murakami Y, Tamori A, Kanada N.
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: - Pages: 355-360
- DOI
  10.1007/s12328-019-00983-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16472, KAKENHI-PROJECT-17K09467, KAKENHI-PROJECT-19H03641
[Journal Article] Intention-to-treat assessment of glecaprevir + pibrentasvir combination therapy for patients with chronic hepatitis C in the real world.2019
- Author(s)
  Tamori A, Inoue K, Kagawa T, Takaguchi K, Nouso K, Iwasaki Y, Minami M, Hai H, Enomoto M, Kawada N.
- Journal Title
  
  Hepatol Res
  
  Volume: 49 Pages: 1365-1373
- DOI
  10.1111/hepr.13410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03641
[Journal Article] Association between Functional Dyspepsia and Gastric Depressive Erosions in Japanese Subjects.2019
- Author(s)
  Tanaka F, Tominaga K, Fujikawa Y, Morisaki T, Otani K, Hosomi S, Nagami Y, Kamata N, Taira K, Nakano A, Kimura T, Yamagami H, Tanigawa T, Morikawa H, Fukumoto S, Watanabe T, Kawada N, Hirata K, Fujiwara Y.
- Journal Title
  
  Intern Med
  
  Volume: 58 Pages: 321-328
- NAID
  130007588506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03641
[Journal Article] Last crusade against HCV: Direct-acting antiviral treatment for marginalized populations.2019
- Author(s)
  Fujii H, Enomoto M, Murakami Y, Hagihara A, Kawada N, Saito S.
- Journal Title
  
  J Viral Hepat
  
  Volume: 26 Pages: 1501-1501
- DOI
  10.1111/jvh.13190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03641
[Journal Article] Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells.2019
- Author(s)
  Odagiri Naoshi、Matsubara Tsutomu、Higuchi Moe, Takada Sayuri, Urushima Hayato, Sato-Matsubara Misako, Teranishi Yuga, Yoshizato Katsutoshi, Kawada Norifumi, Ikeda Kazuo.
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 455(1-2) Pages: 7-19
- DOI
  10.1007/s11010-018-3466-x
- NAID
  120006847891
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18012, KAKENHI-PROJECT-16H05290, KAKENHI-PROJECT-16K08472, KAKENHI-PROJECT-16K19362, KAKENHI-PROJECT-18K07952
[Journal Article] Role of the Gut-Liver Axis in Liver Inflammation, Fibrosis, and Cancer: A Special Focus on the Gut Microbiota Relationship.2019
- Author(s)
  Ohtani N, Kawada N.
- Journal Title
  
  Hepatol Commun
  
  Volume: 3 Pages: 456-470
- DOI
  10.1002/hep4.1331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03641
[Journal Article] Switching to tenofovir disoproxil fumarate vs continuing treatment in patients with chronic hepatitis B who maintain long-term virological response to entecavir therapy: A randomized trial.2019
- Author(s)
  Iida-Ueno A, Enomoto M, Kozuka R, Tamori A, Kawada N.
- Journal Title
  
  J Med Virol
  
  Volume: 91 Pages: 1295-1300
- DOI
  10.1002/jmv.25442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03641
[Journal Article] The presence of multiple NS 5A RAS s is associated with the outcome of sofosbuvir and ledipasvir therapy in NS 5A inhibitor‐na?ve patients with chronic HCV genotype 1b infection in a real‐world cohort2018
- Author(s)
  Kozuka R, Hai H, Motoyama H, Hagihara A, Fujii H, Uchida-Kobayashi S, Mordkawa H, Enomoto M, Murakami Y, Kanada N, Tamori A
- Journal Title
  
  Journal of Viral Hepatitis
  
  Volume: - Pages: 535-542
- DOI
  10.1111/jvh.12850
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09019, KAKENHI-PROJECT-17K09467, KAKENHI-PROJECT-16K09369
[Journal Article] Stagnation of histopathological improvement is a predictor of hepatocellular carcinoma development after hepatitis C Virus eradication2018
- Author(s)
  Motoyama H, Tamori A, Kubo S, Uchida-Kobayashi S, Takemura S, Tanaka S, Ohfuji S, Teranishi Y, Kozuka R, Kawamura E, Hagihara A, Morikawa H, Enomoto M, Murakami Y, Kawada N.
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Pages: 0194163-0194163
- DOI
  10.1371/journal.pone.0194163
- NAID
  120006411697
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04124, KAKENHI-PROJECT-15K09019, KAKENHI-PROJECT-15K10194, KAKENHI-PROJECT-17K09467, KAKENHI-PROJECT-18K08654, KAKENHI-PROJECT-16H05290, KAKENHI-PROJECT-16K09369
[Journal Article] Successful direct-acting antiviral treatment of three patients with genotype 2/1 recombinant hepatitis C virus2018
- Author(s)
  Okada Masako、Hai Hoang、Tamori Akihiro、Uchida-Kobayashi Sawako、Enomoto Masaru、Kumada Hiromitsu、Kawada Norifumi
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 印刷中
- DOI
  10.1007/s12328-018-0922-9
- NAID
  120006866794
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369
[Journal Article] Short-term histological evaluations after achieving a sustained virological response to direct-acting antiviral treatment for chronic hepatitis C2018
- Author(s)
  Enomoto Masaru、Ikura Yoshihiro、Tamori Akihiro、Kozuka Ritsuzo、Motoyama Hiroyuki、Kawamura Etsushi、Hagihara Atsushi、Fujii Hideki、Uchida-Kobayashi Sawako、Morikawa Hiroyasu、Murakami Yoshiki、Kawada Norifumi
- Journal Title
  
  United European Gastroenterol J
  
  Volume: 6 Pages: 1391-1400
- DOI
  10.1177/2050640618791053
- NAID
  120006533846
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09467, KAKENHI-PROJECT-15K08649, KAKENHI-PROJECT-16K09369
[Journal Article] Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice2018
- Author(s)
  Thi Thanh Hai N, Thuy LTT, Shiota A, Kadono C, Daikoku A, Hoang DV, Dat NQ, Sato-Matsubara M, Yoshizato K, Kawada N.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 17860-17860
- DOI
  10.1038/s41598-018-36215-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05290, KAKENHI-PROJECT-16K19363
[Journal Article] Remission of Psoriasis After Treatment of Chronic Hepatitis C Virus Infection With Direct-Acting Antivirals2018
- Author(s)
  Enomoto Masaru、Tateishi Chiharu、Tsuruta Daisuke、Tamori Akihiro、Kawada Norifumi
- Journal Title
  
  Annals of Internal Medicine
  
  Volume: 168 Pages: 678-678
- DOI
  10.7326/l17-0613
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369
[Journal Article] Low incidence of hepatitis B virus reactivation and subsequent hepatitis in patients with chronic hepatitis C receiving direct-acting antiviral therapy.2018
- Author(s)
  Tamori A.、Abiru S.、Enomoto H.、Kioka K.、Korenaga M.、Tani J.、Enomoto M.、Sugiyama M.、Masaki T.、Kawada N.、Yatsuhashi H.、Nishiguchi S.、Mizokami M.
- Journal Title
  
  J Viral Hepat. 2
  
  Volume: - Pages: 608-611
- DOI
  10.1111/jvh.12840
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369, KAKENHI-PROJECT-16K09388
[Journal Article] Correlation between polymorphism in the inosine triphosphatase and the reductions in hemoglobin concentration and ribavirin dose during sofosbuvir and ribavirin therapy.2017
- Author(s)
  Kozuka R, Hai H, Teranishi Y, Motoyama H, Kawamura E, Hagihara A, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawada N, Tamori A.
- Journal Title
  
  JGastroenterol Hepatol.
  
  Volume: 32 Pages: 1495-1502
- NAID
  120006510936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05290
[Journal Article] Detection of HCV RNA in Sustained Virologic Response to?Direct-Acting Antiviral Agents: Occult or Science Fiction?2017
- Author(s)
  Enomoto Masaru、Murakami Yoshiki、Kawada Norifumi
- Journal Title
  
  Gastroenterology
  
  Volume: 153 Pages: 327-328
- DOI
  10.1053/j.gastro.2017.03.075
- Data Source
  KAKENHI-PROJECT-16K09369
[Journal Article] Long-Term Follow-Up of Resistance-Associated Substitutions in Hepatitis C Virus in Patients in Which Direct Acting Antiviral-Based Therapy Failed2017
- Author(s)
  Yoshida Kanako、Hai Hoang、Tamori Akihiro、Teranishi Yuga、Kozuka Ritsuzo、Motoyama Hiroyuki、Kawamura Etsushi、Hagihara Atsushi、Uchida-Kobayashi Sawako、Morikawa Hiroyasu、Enomoto Masaru、Murakami Yoshiki、Kawada Norifumi
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 18 Pages: 962-962
- DOI
  10.3390/ijms18050962
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369, KAKENHI-PROJECT-17K09467, KAKENHI-PROJECT-15K09019
[Journal Article] "Long-Term Follow-Up of Resistance-Associated Substitutions in Hepatitis C Virus in Patients in Which Direct Acting Antiviral-Based Therapy Failed.2017
- Author(s)
  Yoshida K, Hai H, Tamori A, Teranishi Y, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawada N.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05290
[Journal Article] Interstitial fluid flow-induced growth potential and hyaluronan synthesis of fibroblasts in a fibroblast-populated stretched collagen gel culture.2017
- Author(s)
  Saito N, Adachi H, Tanaka H, Nakata S, Kawada N, Oofusa K, Yoshizato K.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1861 Pages: 2261-2273
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05290
[Journal Article] Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice.2017
- Author(s)
  Van Thuy TT, Thuy LT, Yoshizato K, Kawada N.
- Journal Title
  
  Sci Rep.
  
  Volume: 3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05290
[Journal Article] Polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with chronic hepatitis C-related hepatocellular carcinoma.2017
- Author(s)
  Hai Hoang、Tamori Akihiro、Thuy Le Thi Thanh、Yoshida Kanako、Hagihara Atsushi、Kawamura Etsushi、Uchida-Kobayashi Sawako、Morikawa Hiroyasu、Enomoto Masaru、Murakami Yoshiki、Kawada Norifumi
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 11912-11912
- DOI
  10.1038/s41598-017-10363-5
- NAID
  120006346630
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369, KAKENHI-PROJECT-17K09467, KAKENHI-PROJECT-16K19363, KAKENHI-PROJECT-15K09019
[Journal Article] ITPA polymorphism correlates with the reductions in hemoglobin concentration and ribavirin dose during sofosbuvir and ribavirin therapy.2017
- Author(s)
  Tamori A, Yoshida K, Kurai O, Kioka K, Hai H, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawada N
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 46 Pages: 1311-1320
- DOI
  10.1111/jgh.13743
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860522, KAKENHI-PROJECT-15K09019, KAKENHI-PROJECT-16K09369, KAKENHI-PROJECT-17K09467
[Journal Article] Detection of HCV RNA in Sustained Virologic Response to Direct-Acting Antiviral Agents: Occult or Science Fiction?2017
- Author(s)
  Enomoto M, Murakami Y, Kawada N.
- Journal Title
  
  Gastroenterology
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369
[Journal Article] The impact of hepatitis C virus outside the liver: Evidence from Asia.2017
- Author(s)
  Younossi ZM, Tanaka A, Eguchi Y, Lim YS, Yu ML, Kawada N, Dan YY, Brooks-Rooney C, Negro F, Mondelli MU.
- Journal Title
  
  Liver Int.
  
  Volume: 37 Pages: 159-172
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05290
[Journal Article] Outcomes for Cirrhotic Patients with Hepatitis C Virus 1b Treated with Asunaprevir and Daclatasvir Combination2017
- Author(s)
  Tamori Akihiro、Hai Hoang、Uchida-Kobayashi Sawako、Enomoto Masaru、Kozuka Ritsuzo、Motoyama Hiroyuki、Kawamura Etsushi、Hagihara Atsushi、Teranishi Yuga、Yoshida Kanako、Morikawa Hiroyasu、Murakami Yoshiki、Kawada Norifumi
- Journal Title
  
  Ann Hepatol.
  
  Volume: 16 Pages: 734-741
- DOI
  10.5604/01.3001.0010.2732
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369, KAKENHI-PROJECT-17K09467, KAKENHI-PROJECT-15K09019
[Journal Article] 3.Absence of cytoglobin promotes multiple organ abnormalities in aged mice2016
- Author(s)
  Thuy le TT
- Journal Title
  
  Scientific Reports
  
  Volume: - Pages: 1-15
- DOI
  10.1038/srep24990
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05290, KAKENHI-PROJECT-26860522, KAKENHI-PROJECT-16K19363
[Journal Article] Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.2016
- Author(s)
  Thuｙ　Le　ＴT, Nguen Thi Thanh Hai, Hoang Hai, Norifumi Kawada.
- Journal Title
  
  Histol Histopathol.
  
  Volume: 31 Pages: 257-267
- Data Source
  KAKENHI-PROJECT-26860522
[Journal Article] Putting "sticky notes" on the electronic medical record to promote intra-hospital referral of hepatitis B and C virus-positive patients to hepatology specialists: an exploratory study.2016
- Author(s)
  Fujii H, Yamaguchi S, Kurai O, Miyano M, Ueda W, Oba H, Aoki T, Enomoto M, Kawada N, Okawa K.
- Journal Title
  
  BMC Infect Dis.
  
  Volume: 16 Pages: 410-410
- DOI
  10.1186/s12879-016-1765-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369
[Journal Article] Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with hepatitis C virus genotype 1b.2016
- Author(s)
  Tamori A, Yoshida K, Kurai O, Kioka K, Hai H, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawara N.
- Journal Title
  
  Hepatol Res.
  
  Volume: 46 Pages: 1311-1320
- DOI
  10.1111/hepr.12689
- NAID
  120006534926
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09019, KAKENHI-PROJECT-16K09369
[Journal Article] Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases.2016
- Author(s)
  Thuy Le TT, Hai NT, Hai H, Kawada N.
- Journal Title
  
  Histol Histopathol.
  
  Volume: 31 Pages: 257-267
- Data Source
  KAKENHI-PROJECT-25293177
[Journal Article] Recent Advances in Antiviral Therapy for Chronic Hepatitis C.2016
- Author(s)
  Tamori A, Enomoto M, Kawada N.
- Journal Title
  
  Mediators Inflamm.
  
  Volume: 2016 Pages: 1-11
- DOI
  10.1155/2016/6841628
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09019, KAKENHI-PROJECT-16K09369
[Journal Article] Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism2015
- Author(s)
  Yuga Teranishi, Tsutomu Matsubara, Kristopher W Krausz, Thi T T Le, Frank J Gonzalez, Katsutoshi Yoshizato,Kazuo Ikeda and Norifumi Kawada
- Journal Title
  
  Laboratory Investigation
  
  Volume: 00 Pages: 1-10
- Data Source
  KAKENHI-PROJECT-25293177
[Journal Article] Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts.2015
- Author(s)
  Kawada N.
- Journal Title
  
  Front Physiol.
  
  Volume: 6 Pages: 329-329
- DOI
  10.3389/fphys.2015.00329
- Data Source
  KAKENHI-PROJECT-25293177
[Journal Article] Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway.2015
- Author(s)
  Thuy le TT, Matsumoto Y, Thuy TT, Hai H, Suoh M, Urahara Y, Motoyama H, Fujii H, Tamori A, Kubo S, Takemura S, Morita T, Yoshizato K, Kawada N
- Journal Title
  
  Am J Pathol.
  
  Volume: 185 Pages: 1045-1060
- DOI
  10.1016/j.ajpath.2014.12.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10194, KAKENHI-PROJECT-25293177
[Journal Article] Long-Term Outcome of Sequential Therapy with Lamivudine Followed by Interferon-β in Nucleoside-Naive, Hepatitis B e-Antigen-Positive Patients with Chronic Hepatitis B Virus Genotype C Infection2015
- Author(s)
  Enomoto M, Nishiguchi S, Tamori A, Kozuka R, Hayashi T, Kohmoto MT, Jomura H, Morikawa H, Murakami Y, Shiomi S, Kawada N
- Journal Title
  
  J Interferon Cytokine Res
  
  Volume: 35 Pages: 613-620
- DOI
  10.1089/jir.2014.0234
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461006
[Journal Article] Effects on anemia of drug adjustment in patients with chronic hepatitis C during teleaprevir-combined therapy.2015
- Author(s)
  Tamori A, Kioka K, Sakaguchi H, Enommoto M, Hai H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Iwai S, Morikawa H, Murakami Y, Kawadaki Y, Tsuruta D, Kawada N.
- Journal Title
  
  Ann Hepatol.
  
  Volume: 14 Pages: 28-35
- Data Source
  KAKENHI-PROJECT-26860522
[Journal Article] Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.2015
- Author(s)
  Thuy Le TT, Matsumoto Y, Thuy TT, Hai H, Suoh M, Urahara Y, Motoyama H, Fujii,Tamori A, Kubo S, Takemura S, Morita T, Yoshizato K, Kawada N.
- Journal Title
  
  Am J Pathol.
  
  Volume: 185 Pages: 1045-1060
- Data Source
  KAKENHI-PROJECT-26860522
[Journal Article] Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway2015
- Author(s)
  Thuy le TT, Matsumoto Y, Thuy TT, Hai H, Suoh M, Urahara Y, Motoyama H, Fujii H, Tamori A, Kubo S, Takemura S, Morita T, Yoshizato K, Kawada N.
- Journal Title
  
  Am J Pathol.
  
  Volume: 185 Pages: 1045-1060
- Data Source
  KAKENHI-PROJECT-25293177
[Journal Article] Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B2014
- Author(s)
  Enomoto M, Morikawa H, Tamori A, Kawada N
- Journal Title
  
  World J Gastroenterol
  
  Volume: 20 Pages: 12031-12038
- DOI
  10.3748/wjg.v20.i34.12031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461006
[Journal Article] Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver.2014
- Author(s)
  Motoyama H, Komiya T, Thuy le TT, Tamori A, Enomoto M, Morikawa H, Iwai S,Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Murakami Y, Yoshizato K,Kawada N.
- Journal Title
  
  Lab Invest.
  
  Volume: 94 Pages: 192-207
- Data Source
  KAKENHI-PROJECT-25293177
[Journal Article] Entecavir and interferon-α sequential therapy in Japanese patients with hepatitis B e antigen-positive chronic hepatitis B2013
- Author(s)
  Enomoto M, Nishiguchi S, Tamori A, Kobayashi S, Sakaguchi H, Shiomi S, Kim SR, Enomoto H, Saito M, Imanishi H, Kawada N.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 48 Pages: 397-404
- DOI
  10.1007/s00535-012-0645-5
- NAID
  10031169214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590985, KAKENHI-PROJECT-25461006
[Journal Article] Combination therapy with a nucleos(t)ide analogue and interferon for chronic hepatitis B : simultaneous or sequential2013
- Author(s)
  Enomoto M, Tamori A, Nishiguchi S, Kawada N.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 48 Pages: 999-1005
- DOI
  10.1007/s00535-012-0742-5
- NAID
  10031201970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590985, KAKENHI-PROJECT-25461006
[Journal Article] Inflammation and fibrogenesis in steatohepatitis2012
- Author(s)
  Fujii H, Kawada N.
- Journal Title
  
  J Gastroenterol
  
  Volume: 47 Pages: 215-25
- NAID
  10030559576
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] Antifibrotic role of macrophage migration inhibitory factor : discovery of an unexpected function. Thuy le TT2012
- Author(s)
  Kawada N.
- Journal Title
  
  Hepatology
  
  Volume: 55 Pages: 1295-7
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] N-Acetylglucosaminyltransferase V regulates TGF-βresponse in hepatic stellate cells and the progression of steatohepatitis2012
- Author(s)
  Kamada Y, Mori K, Matsumoto H, Kiso S, Yoshida Y, Shinzaki S, Hiramatsu N, Ishii M, Moriwaki K, Kawada N, Takehara T, Miyoshi E.
- Journal Title
  
  Glycobiology
  
  Volume: 22 Pages: 778-87
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway2012
- Author(s)
  Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N, Fujimoto J.
- Journal Title
  
  Lab Invest
  
  Volume: 92 Pages: 57-71
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Antifibrotic role of macrophage migration inhibitory factor : discovery of an unexpected function. Thuy le TT2012
- Author(s)
  Kawada N.
- Journal Title
  
  Hepatology
  
  Volume: 55 Pages: 1295-7
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Inflammation and fibrogenesis in steatohepatitis2012
- Author(s)
  Fujii H, Kawada N.
- Journal Title
  
  J Gastroenterol
  
  Volume: 47 Pages: 215-25
- NAID
  10030559576
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis2012
- Author(s)
  Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N
- Journal Title
  
  Gut
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] N-Acetylglucosaminyltransferase V regulates TGF-βresponse in hepatic stellate cells and the progression of steatohepatitis2012
- Author(s)
  Kamada Y, Mori K, Matsumoto H, Kiso S, Yoshida Y, Shinzaki S, Hiramatsu N, Ishii M, Moriwaki K, Kawada N, Takehara T, Miyoshi E.
- Journal Title
  
  Glycobiology
  
  Volume: 22 Pages: 778-87
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Response-guided therapy for patients with chronic hepatitis who have high viral loads of hepatitis C virus genotype 22012
- Author(s)
  Yamaguchi Y, Tamori A, Tanaka Y, Iwai S, Kobayashi S, Fujii H, Morikawa H, Hagihara A, Enomoto M, Kawada N
- Journal Title
  
  Hepatol Res
  
  Volume: (印刷中)
- DOI
  10.1111/j.1872-034x.2011.00956.x
- NAID
  10031144269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590856
[Journal Article] Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway2012
- Author(s)
  Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N, Fujimoto J.
- Journal Title
  
  Lab Invest
  
  Volume: 92 Pages: 57-71
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis.2012
- Author(s)
  Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N.
- Journal Title
  
  Gut
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Mosapride Citrate on Gastric Emptying in Interferon-Induced Gastroparesis2012
- Author(s)
  Kawamura E, Enomoto M, Kotani K, Hagihara A, Fujii H, Kobayashi S, Iwai S, Morikawa H, Kawabe J, Tominaga K, Tamori A, Shiomi S, Kawada N
- Journal Title
  
  Dig Dis Sci
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590856
[Journal Article] MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis2012
- Author(s)
  Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N
- Journal Title
  
  Gut
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590856
[Journal Article] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions2011
- Author(s)
  Nishi H, Inagi R, Kawada N, Yoshizato K, Mimura I, Fujita T, Nangaku M.
- Journal Title
  
  Am J Pathol
  
  Volume: 178 Pages: 128-39
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions2011
- Author(s)
  Nishi H, Inagi R, Kawada N, Yoshizato K, Mimura I, Fujita T, Nangaku M.
- Journal Title
  
  Am J Pathol
  
  Volume: 178 Pages: 128-39
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] Evolution of hepatic fibrosis research2011
- Author(s)
  Kawada N.
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 199-208
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation2011
- Author(s)
  Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N.
- Journal Title
  
  J Cell Physiol
  
  Volume: 226 Pages: 2535-42
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] Favorable factors for re-treatment with pegylated interferon α2a plus ribavirin in patients with high viral loads of genotype 1 hepatitis C virus2011
- Author(s)
  Tamori A, Kioka K, Kurai O, Sakaguchi H, Enomoto M, Fujii H, Kobayashi S, Iwai S, Morikawa H, Yamaguchi S, Kawasaki Y, Oka H, Tanaka Y, Kawada N
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 1169-77
- NAID
  10031144195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590856
[Journal Article] Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice. Thuy le TT2011
- Author(s)
  Morita T, Yoshida K, Wakasa K, Iizuka M, Ogawa T, Mori M, Sekiya Y, Momen S, Motoyama H, Ikeda K, Yoshizato K, Kawada N.
- Journal Title
  
  Am J Pathol
  
  Volume: 179 Pages: 1050-60
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Cytoglobin expression of rectal subepithelial myofibroblasts : significant alterations of cytoglobin+stromal cells in long-standing ulcerative colitis2011
- Author(s)
  Okayasu I, Mikami T, Yoshida T, Hana K, Yokozawa M, Sada M, Fujiwara M, Kawada N.
- Journal Title
  
  Histol Histopathol
  
  Volume: 26 Pages: 679-88
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] Evolution of hepatic fibrosis research2011
- Author(s)
  Kawada N.
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 199-208
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Cytoglobin expression of rectal subepithelial myofibroblasts : significant alterations of cytoglobin+stromal cells in long-standing ulcerative colitis2011
- Author(s)
  Okayasu I, Mikami T, Yoshida T, Hana K, Yokozawa M, Sada M, Fujiwara M, Kawada N.
- Journal Title
  
  Histol Histopathol
  
  Volume: 26 Pages: 679-88
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice. Thuy le TT2011
- Author(s)
  Morita T, Yoshida K, Wakasa K, Iizuka M, Ogawa T, Mori M, Sekiya Y, Momen S, Motoyama H, Ikeda K, Yoshizato K, Kawada N.
- Journal Title
  
  Am J Pathol
  
  Volume: 179 Pages: 1050-60
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] Could trastuzumab suppress hepatitis C virus in a patient with chronic hepatitis and breast cancer?2011
- Author(s)
  Tamori A, Kawajiri H, Takashima T, Motoyama H, Morikawa H, Enomoto M, Hirakawa K, Kawada N
- Journal Title
  
  Am J Gastroenterol
  
  Volume: 106 Pages: 1865-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590856
[Journal Article] High prevalence of hepatitis C virus infection in Airin district, Osaka, Japan : A hospital-based study of 1162 patients2011
- Author(s)
  Yamaguchi Y, Enomoto M, Fujii H, Tamori A, Sakaguchi H, Tanigawa T, Watanabe K, Fujiwara Y, Arakawa T, Harihara S, Monna T, Kawada N
- Journal Title
  
  Repatol Res
  
  Volume: 41 Pages: 731-7
- DOI
  10.1111/j.1872-034x.2011.00834.x
- NAID
  10031144145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590856
[Journal Article] Real-time tissue elastography as a tool for the noninvasive assessment of liver stiffness in patients with chronic hepatitis C2011
- Author(s)
  Morikawa H, Fukuda K, Kobayashi S, Fujii H, Iwai S, Enomoto M, Tamori A, Sakaguchi H, Kawada N
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 350-8
- NAID
  10029027887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590856
[Journal Article] Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation2011
- Author(s)
  Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N.
- Journal Title
  
  J Cell Physiol
  
  Volume: 226 Pages: 2535-42
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Inhibition of pancreatic stellate cell activation by halofuginone prevents pancreatic xenograft tumor development2010
- Author(s)
  Spector I, Honig H, Kawada N, Nagler A, Genin O, Pines M.
- Journal Title
  
  Pancreas
  
  Volume: 39 Pages: 1008-15
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbits2010
- Author(s)
  Ogawa T, Fujii H, Yoshizato K, Kawada N.
- Journal Title
  
  Am J Pathol
  
  Volume: 177 Pages: 153-65
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] Inhibition of pancreatic stellate cell activation by halofuginone prevents pancreatic xenograft tumor development2010
- Author(s)
  Spector I, Honig H, Kawada N, Nagler A, Genin O, Pines M.
- Journal Title
  
  Pancreas
  
  Volume: 39 Pages: 1008-15
- Data Source
  KAKENHI-PROJECT-22650224
[Journal Article] A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbits2010
- Author(s)
  Ogawa T, Fujii H, Yoshizato K, Kawada N
- Journal Title
  
  Am J Pathol
  
  Volume: 177 Pages: 153-65
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet.2010
- Author(s)
  Mu YP, Ogawa T, Kawada N.
- Journal Title
  
  Lab Invest. 90
  
  Pages: 245-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390232
[Journal Article] Emerging antiviral drugs for hepatitis C virus2009
- Author(s)
  Enomoto M, Tamori A, Kawada N
- Journal Title
  
  Rev Recent Clin Trials
  
  Volume: 4 Pages: 179-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590856
[Journal Article] Emerging antiviral drugs for hepatitis C virus2009
- Author(s)
  Enomoto M, Tamori A, Kawada N
- Journal Title
  
  Rev Recent Clin Trials 4
  
  Pages: 179-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590856
[Journal Article] Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis.2007
- Author(s)
  Kinoshita K, Iimuro Y, Fujimoto J, Inagaki Y, Namikawa K, Kiyama H, Nakajima Y, Otogawa K, Kawada N, Friedman SL, Ikeda K.
- Journal Title
  
  Gut 56(3)
  
  Pages: 396-404
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591513
[Journal Article] Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats.2007
- Author(s)
  Kinoshita K, Iimuro Y, Otogawa K, Saika S, Inagaki Y, Nakajima Y, Kawada N, Fujimoto J, Friedman SL, Ikeda K.
- Journal Title
  
  Gut 56(5)
  
  Pages: 706-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591513
[Journal Article] Human hepatic stellate cells are resistant to apoptosis : implications for human fibrogenic liver disease.2006
- Author(s)
  Kawada N.
- Journal Title
  
  Gut. 55(8)
  
  Pages: 1073-1074
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390376
[Journal Article] BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2.2006
- Author(s)
  Izumi N, Mizuguchi S, Inagaki Y, Saika S, Kawada N, Nakajima Y, Inoue K, Suehiro S, Friedman SL, Ikeda K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol. 290(1)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590618
[Journal Article] BMP-7 opposes TGF-betal-mediated collagen induction in mouse pulmonary myofibroblasts through Id2.2006
- Author(s)
  Izumi N, Mizuguchi S, Inagaki Y, Saika S, Kawada N, Nakajima Y, Inoue K, Suehiro S, Friedman SL, Ikeda K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol. 290(1)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390376
[Journal Article] Rho kinases regulate endothelial invasion and migration during valvuloseptal endocardial cushion tissue formation.2006
- Author(s)
  Sakabe M, Ikeda K, Nakatani K, Kawada N, Imanaka-Yoshida K, Yoshida T, Yamagishi T, Nakajima Y.
- Journal Title
  
  Dev Dyn. 235(1)
  
  Pages: 94-104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390376
[Journal Article] Cancer serum proteomics in gastroenterology.2006
- Author(s)
  Kawada N
- Journal Title
  
  Gastroenterology 130
  
  Pages: 1917-1919
- Data Source
  KAKENHI-PROJECT-18659214
[Journal Article] Human hepatic stellate cells are resistant to apoptosis : implications for human fibrogenic liver disease.2006
- Author(s)
  Kawada N
- Journal Title
  
  Gut 55
  
  Pages: 1073-1074
- Data Source
  KAKENHI-PROJECT-18659214
[Journal Article] Human hepatic stellate cells are resistant to apoptosis : implications for human fibrogenic liver disease2006
- Author(s)
  Kawada N
- Journal Title
  
  Gut 55(8)
  
  Pages: 1073-1074
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390376
[Journal Article] Analysis of proteins dominantly expressed in hepatic stellate cells of activated phenotype.2005
- Author(s)
  Kawada N.
- Journal Title
  
  Methods Mol Med. 117
  
  Pages: 371-379
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590618
[Journal Article] Analysis of proteins dominantly expressed in hepatic stellate cells of activated phenotype.2005
- Author(s)
  Kawada N
- Journal Title
  
  Methods Mol Med. 117
  
  Pages: 371-379
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590618
[Journal Article] Effect of S-adenosyl-L-methionine on the activation, proliferation and contraction of hepatic stellate cells.2005
- Author(s)
  Matsui H, Kawada N
- Journal Title
  
  Eur J Pharmacol. 509
  
  Pages: 31-36
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590618
[Journal Article] Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice.2005
- Author(s)
  Okuyama H, Nakamura H, Shimahara Y, Uyama N, Kwon YW, Kawada N, Yamaoka Y, Yodoi J.
- Journal Title
  
  J Hepatol. 42(1)
  
  Pages: 117-123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390376
[Journal Article] Effect of S-adenosyl-L-methionine on the activation, proliferation and contraction of hepatic stellate cells.2005
- Author(s)
  Matsui H, Kawada N.
- Journal Title
  
  Eur J Pharmacol. 509(1)
  
  Pages: 31-36
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590618
[Journal Article] Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.2005
- Author(s)
  Inagaki Y, Kushida M, Higashi K, Itoh J, Higashiyama R, Hong YY, Kawada N, Namikawa K, Kiyama H, Bou-Gharios G, Watanabe T, Okazaki I, Ikeda K.
- Journal Title
  
  Gastroenterology. 129(1)
  
  Pages: 259-268
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590618
[Journal Article] Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin.2005
- Author(s)
  Sawai H, Makino M, Mizutani Y, Ohta T, Sugimoto H, Uno T, Kawada N, Yoshizato K, Kitagawa T, Shirro Y
- Journal Title
  
  Biochemistry. 44(40)
  
  Pages: 13257-13265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590618
[Journal Article] Effect of S-adenosyl-L-methionine on the activation, proliferation and contraction of hepatic stellate cells.2005
- Author(s)
  Matsui H, Kawada N.
- Journal Title
  
  Eur J Pharmacol. 509
  
  Pages: 31-36
- Data Source
  KAKENHI-PROJECT-16590618
[Journal Article] Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice.2005
- Author(s)
  Okuyama H, Nakamura H, Shimahara Y, Uyama N, Kwon YW, Kawada N, Yamaoka Y, Yodoi J.
- Journal Title
  
  J Hepatol. 42(1)
  
  Pages: 117-123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590618
[Journal Article] Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice.2003
- Author(s)
  H.Okuyama, H.Nakamura, Y.Shimahara, S.Araya, N.Kawada, Y.Yamaoka, J.Yodoi
- Journal Title
  
  Hepatology 37
  
  Pages: 1015-1025
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Journal Article] Regulation of Cultured Rat Hepatocyte Proliferation by Stellate Cells.2002
- Author(s)
  Uyama-N., Shimahara-Y., Kawada-N., Seki-S., Okuyama-H., Iimuro-Y., Yamaoka-Y.
- Journal Title
  
  Journal of Hepatology 36
  
  Pages: 590-599
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13557100
[Journal Article] The hepatic stellate cell in the post-genomic era.2002
- Author(s)
  H.Okuyama, Y.Shimahara, N.Kawada
- Journal Title
  
  Histology and Histopathology 17
  
  Pages: 487-495
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Journal Article] Regulation of Cultured Rat Hepatocyte Proliferation by Stellate Cells.2002
- Author(s)
  N.Uyama, Y.Shimahara, N.Kawada, S.Seki, H.Okuyama, Y.Iimuro Y.Yamaoka
- Journal Title
  
  J Hepatol 36
  
  Pages: 590-599
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Journal Article] Characterization of a stellate cell activation-associated protein (S TAP) with peroxidase activity found in rat hepatic stellate cells.2001
- Author(s)
  Kawada, -N., Kristensen, -D.-B., Asahina, -K., Nakatani, -K., Minamiyama, -Y., Seki, -S., Yoshizato,-K.
- Journal Title
  
  J-Biol-Chem. 276(27)
  
  Pages: 25318-25323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13557100
[Journal Article] Regulation of cell growth by redox-mediated extracellular proteolysis of platelet-derived growth factor receptor beta.2001
- Author(s)
  Okuyama, -H., Shimahara, -Y., Kawada, -N., Seki, -S., Kristensen, -D.-B., Yoshizato, -K., Uyama, -N., Yamaoka,-Y.
- Journal Title
  
  J-Biol-Chem. 276(30)
  
  Pages: 28274-28280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13557100
[Journal Article] N-acetyl cysteine inhibits PDGF-dependent proliferation of primary cultured o rat hepatic stellate cells through degradation of PDGF receptor and attenuates progress of liver fibrosis in rat models.2001
- Author(s)
  Okuyama-H., Kawada-N., Shim ahara-Y., Uyama-N., Yamaoka-Y.
- Journal Title
  
  Cells of Hepatic Sinusoid 8
  
  Pages: 284-276
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13557100
[Journal Article] The interaction between hepatocytes and stellate cells on individual cell proliferation and differentiation2001
- Author(s)
  Uyama-N., Kawada-N., Ikuyama-H., Iimuro-Y., Kaneda-K., Shimahara-Y., Yamaoka-Y.
- Journal Title
  
  Cells of Hepatic Sinusoid 8
  
  Pages: 51-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13557100
[Patent] 抗線維化剤2017
- Inventor(s)
  河田則文、池田一雄、松原勤、松原三佐子
- Industrial Property Rights Holder
  河田則文、池田一雄、松原勤、松原三佐子
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-16H05290
[Patent] 肝線維症の存在及び/又は肝線維症の重症度の判定方法、判定マーカー、判定用キット、肝線維症の治療の効果予測方法、効果予測マーカー、並びに効果予測用キット2010
- Inventor(s)
  河田則文、榎本大、小川智弘
- Industrial Property Rights Holder
  公立大学法人大阪市立大学
- Industrial Property Number
  2010-281254
- Filing Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-22650224
[Patent] サイトグロビン遺伝子ノックアウト非ヒト癌モデル動物2010
- Inventor(s)
  河田則文
- Industrial Property Rights Holder
  河田則文
- Filing Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-21390232
[Patent] サイトグロビン遺伝子ノックアウト非ヒト癌モデル動物2010
- Inventor(s)
  河田則文
- Industrial Property Rights Holder
  河田則文
- Industrial Property Number
  2010-052244
- Filing Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-21390232
[Patent] 肝線維症の存在及び/又は肝線維症の重症度の判定方法、判定マーカー、判定用キット、肝線維症の治療の効果予測方法、効果予測マーカー、並びに効果予測用キット2010
- Inventor(s)
  河田則文、榎本大、小川智弘
- Industrial Property Rights Holder
  公立大学法人大阪市立大学
- Industrial Property Number
  2010-281254
- Filing Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-21590856
[Patent] サイトグロビン遺伝子ノックアウト非ヒト癌モデル動物2010
- Inventor(s)
  河田則文
- Industrial Property Rights Holder
  河田則文
- Filing Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-22650224
[Patent] 肝線維症の存在及び/又は肝線維症の重症度の判定方法、判定マーカー、判定用キット、肝線維症の治療の効果予測方法、効果予測マーカー、並びに効果予測用キット2010
- Inventor(s)
  河田則文、榎本大、小川智弘
- Industrial Property Rights Holder
  公立大学法人大阪市立大学
- Industrial Property Number
  2010-281254
- Filing Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-21390232
[Patent] サイトグロビン遺伝子ノックアウト非ヒト癌モデル動物2010
- Inventor(s)
  河田則文
- Industrial Property Rights Holder
  河田則文
- Filing Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-21390232
[Presentation] Renal Shear Wave Velocity Measurement can Predict the Response to Tolvaptan Treatment for Hepatic Ascites2019
- Author(s)
  Hiroyuki Motoyama, Koji Rinka, Ayane Kasamatsu, Hiroko Ikenaga, Maito Suoh, Naoshi Odagiri, Kanako Yoshida, Kohei Kotani, Atsushi Hagihara, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Selective overexpression of Cytoglobin in stellate cells attenuates their activation and fibrosis development in mice2019
- Author(s)
  Ninh Quoc Dat,河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] 成因不明の肝疾患に対するTransient elastographyの使用経験2019
- Author(s)
  藤井英樹,森川浩安, 河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Noninvasive Assessment of Portal Hemodynamics Using Per-Rectal Portal Scintigraphy: A Comparison with Hepatic Venous Pressure Gradient2019
- Author(s)
  Kohei Kotani, Sawako Uchida-Kobayashi, Naoshi Odagiri, Kanako Yoshida, Hiroyuki Motoyama, Atsushi Hagihara, Hideki Fujii, Masaru Enomoto1, Shinichi Hamamoto, Atsushi Jogo, Akira Yamamoto, Shigeaki Higashiyama, Joji Kawabe, Akihiro Tamori, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] 保険診療下におけるパンジェノ型抗HCV治療の効果と安全性―他施設共同研究・第2報―2019
- Author(s)
  田守昭博,榎本大,河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Identification of Gut Bacteria Involved in Hepatic Encephalopathy by the Analysis of Rifaximin Administrated Patients2019
- Author(s)
  Yoshimi Yukawa, Naoko Ohtani, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] 肝表面直下の血流評価による門脈圧亢進症診断2019
- Author(s)
  打田佐和子,菊川佳菜子, 河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] リファキシミンの使用経験と腸内細菌叢に与える影響2019
- Author(s)
  湯川芳美,大谷直子,河田則文
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] TGF-βとサイトグロビンの拮抗作用はヒトNASHにおける星細胞活性化と肝線維化に影響する2019
- Author(s)
  翁良徳、松原三佐子、藤井英樹、河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Histological Evaluations after Achieving a Sustained Virologic Response to DirectActing Antiviral Treatment for Chronic Hepatitis C in a Short Term2019
- Author(s)
  Masaru Enomoto, Yutaka Yasui, Misako Sato-Matsubara, Yoshihiro Ikura, Akihiro Tamori, Ritsuzo Kozuka, Etsushi Kawamura, Atsushi Hagihara, Hideki Fujii1, Sawako Uchida-Kobayashi, Yoshiki Murakami, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] 切除不能肝細胞癌に対する 1 次から 3 次治療の全身化学療法としてのレンバチニブ治療2019
- Author(s)
  周防舞仁, 萩原淳司, 笠松彩音, 岡田雅子, 小田桐直志, 吉田香奈子, 小谷晃平, 元山宏行, 藤井英樹, 打田佐和子, 榎本大, 森川浩安, 村上善基, 田守昭博, 新川寛二, 田中肖吾, 竹村茂一, 久保正二, 河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Prospective Multicenter study of Glecaprevir plus Pibrentasvir combination therapy for patients with chronic hepatitis C2019
- Author(s)
  Tamori A, Iwasa M, Inoue K, Kagawa T, Takaguchi K, Minami M, Iwasaki Y, Nouso K, Hai H, Enomoto M, Kawada N.
- Organizer
  54th European Association for the study of the liver diseases (Vienna)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Wisteria Floribunda Agglutinin Positive MAC-2-Binding Protein Predicts Esophagogastric Varices in Cirrhotic Patients with Chronic Hepatitis C Virus Infection Treated with IFN-Free Direct-Acting Antiviral Agent2019
- Author(s)
  Sawako Uchida-Kobayashi, Kanako Kikukawa, Akihiro Tamori, Naoshi Odagiri, Kanako Yoshida, Kohei Kotani, Hiroyuki Motoyama, Atsushi Hagihara, Hideki Fujii, Masaru Enomoto, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] TGF-β1 transcriptionally repressed cytoglobin expression and enhanced H2O2-induced oxidative DNA damage in activated HSCs.2019
- Author(s)
  Misako Sato-Matsubara, Yoshinori Okina, Tsutomu Matsubara, Atsuko Daikoku1, Krista Rombouts, Le Thi Thanh Thuy, Hideki Fujii1, Kazuo Ikeda, Katsutoshi Yoshizato, Massimo Pinzani, and Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Standardized uptake valueを用いたアシアロシンチグラフィによる新たな肝予備能評価2019
- Author(s)
  小谷晃平,打田佐和子, 小田桐直志, 吉田香奈子, 元山宏行, 藤井英樹, 萩原淳司, 森川浩安, 榎本大, 田守昭博, 河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Recombinant Human Cytoglobin Protects Mice from Chemical Induced Liver Fibrosis2019
- Author(s)
  Ninh Quoc Dat, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Dinh Viet Hoang, Katsutoshi Yoshizato, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Does liver cirrhosis regress? Consideration based on DAA therapy to type C advanced chronic liver disease in Japan2019
- Author(s)
  Kawada N.
- Organizer
  CHESS Forum 2019 for Portal Hypertension
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Cytoglobin suppresses liver fibrosis and cancer in mice by regulating oxidative stress2019
- Author(s)
  Le Thi Thanh Thuy, Ninh Quoc Dat, Hoang Hai, Dinh Viet Hoang, Katsutoshi Yoishizato and Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Cytoglobin suppresses liver fibrosis and cancer in mice by regulating oxidative stress2019
- Author(s)
  Thi Le,河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] DAA治療過去4年間からみた治療不成功因子の検討2019
- Author(s)
  吉田香奈子,田守昭博,河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] 肝炎ウイルス制御下における組織学的な脂肪沈着の程度と関連因子の検討2019
- Author(s)
  岡田雅子,小谷晃平, 田守昭博, 笠松彩音, 周防舞仁, 小田桐直志, 吉田香奈子, 元山宏行, 藤井英樹, 打田佐和子, 榎本大, 村上善基, 河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Putative Role of ERK1/2 Signaling of Senescent Human Hepatic Stellate Cells in Hepatocellular Carcinoma derived from Liver Cirrhosis.2019
- Author(s)
  Naoshi Odagiri, Tsutomu Matsubara, Kazuo Ikeda, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Downregulation of Cytoglobin by TGF-β Leads to Hydroxyl Radical-induced Oxidative DNA Damage in Human HSCs.2019
- Author(s)
  Yoshinori Okina, Misako Sato-Matsubara, Tsutomu Matsubara, Atsuko Daikoku, Hideki Fujii, Kazuo Ikeda, Katsutoshi Yoshizato, Massimo Pinzani, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Role of cytoglibin, the fourth globin in mammals, in liver diseases.2019
- Author(s)
  Le Thi Thanh Thuy, Hoang Hai, and Norifumi Kawada
- Organizer
  VJST2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Deletion Mutations in HCV NS5A Persist and Resist to Subsequent Treatment2019
- Author(s)
  Hai H, Tamori A, Thuy LTT, Yoshida K, Uchida-Kobayashi S, Enomoto M, Kozuka R, Motoyama H, Murakami Y, Kawada N.
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] HCV genotype2型に対するDAA治療の効果と安全性に関する薬剤レジメンの比較2019
- Author(s)
  和田響子, 田守昭博, 小谷晃平, 吉田香奈子, 元山宏行, 藤井英樹, 石津弘隆, 萩原淳司, 打田佐和子, 森川浩安, 榎本大, 村上善基, 河田則文
- Organizer
  第55回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Direct-Acting Antiviral Treatment can Prolong Disease-free Survival after Curative Treatment of HCV-related, Primary Hepatocellular Carcinoma in Patient with Advanced Fibrosis2019
- Author(s)
  Hiroko Ikenaga, SawakoUchida-Kobayashi, Naoshi Odagiri, Kanako Yoshida, Kohei Kotani, Hiroyuki Motoyama, Atsushi Hagihara, Hideki Fuji, Masaru Enomoto, Akihiro Tamori, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Profiling of Circulating Immune Checkpoint Proteins in Advanced HCC Patients2019
- Author(s)
  Minh Phuong Dong, Masaru Enomoto, Thi Thanh Thuy Le, Hai Hoang, Atsushi Hagihara, Sawako Uchida-Kobayashi, Akihiro Tamori, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Identification of gut bacteria involved in hepatic encephalopathy from the analysis of patients administered rifaximin2019
- Author(s)
  Yoshimi Yukawa Muto, Tomonori Kamiya, Shinji Fukuda, Norifumi Kawada , Naoko Ohtani
- Organizer
  Cold Spring Harbor Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Establishment of Orthotopic Hepatocellular Carcinoma on the Background of Fibrosis by Intrahepatic and Intrasplenic Tumor Inoculation in Mice.2019
- Author(s)
  Hoang Huu Truong1, Misako Sato-Matsubar, Thuy Thi Thanh Le, Tsutomu Matsubara, Hai Hoang, Atsuko Daikoku, Yoshinori Okina, Hoang Viet Dinh, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Identification of Lawsone as an Anti-fibrotic Agent based on High-Throughput Screening System with Human COL1A2 Promoter Activity.2019
- Author(s)
  Misako Sato-Matsubara, Tsutomu Matsubara, Atsuko Daikoku, Kazuo Ikeda, Katsutoshi Yoshizato, Norifumi Kawada
- Organizer
  JSH international Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03641
[Presentation] Establishing efficient systems to promote intra-hospital referrals of hepatitis virus carriers to hepatology specialists2018
- Author(s)
  M Enomoto, S Uchida, N Kawada
- Organizer
  JDDW2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369
[Presentation] 肝細胞と肝星細胞の共培養による肝星細胞の活性化制御2018
- Author(s)
  松原三佐子、松原勤、宇留島隼人、大黒敦子、森浦芳枝、門野千穂、池田一雄、河田則文、吉里勝利
- Organizer
  第25回　肝細胞研究会
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] Protective role of hepatic stellate cell-specific overexpression of cytoglobin against liver fibrosis in in vitro and in vivo2018
- Author(s)
  Nguyen Thi Thanh Hai, Le Thi Thanh Thuy, 河田則文
- Organizer
  第54回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] 抗線維化治療法の開発を目指したCytoglobin発現制御機構の解明2018
- Author(s)
  翁良徳, 松原三佐子, 河田則文
- Organizer
  第54回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] “Normal” ALT by central laboratory criteria but >30 U/L for males and >19 U/L for females is predictive of residual inflammation in liver biopsies after sustained virologic response to direct-acting antivirals for chronic hepatitis C2018
- Author(s)
  Masaru Enomoto, Yoshihiro Ikura, Akihiro Tamori, Ritsuzo Kozuka, Hiroyuki Motoyama, Etsushi Kawamura, Atsushi Hagihara, Hideki Fujii, Sawako Uchida-Kobayashi, Hiroyasu Morikawa, Yoshiki Murakami, Norifumi Kawada
- Organizer
  69th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369
[Presentation] DAAs治療非著効後のHCVウイルスから見た再治療戦略2018
- Author(s)
  田守昭博、Hoang Hai、河田則文
- Organizer
  第104回　日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] Neither MICA nor TLL1 polymorphisms associated with hepatocellular carcinoma after HCV eradication by IFN-free therapies2018
- Author(s)
  Hoang Hai, 田守昭博, 河田則文
- Organizer
  第54回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] 肝星細胞におけるTGF-β1/Smadシグナルを介したCytoglobin発見制御機構2017
- Author(s)
  松原三佐子、翁良徳、松原勤、大黒敦子、池田一雄、吉里勝利、河田則文
- Organizer
  第31回肝類洞壁細胞研究会学術集会
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] 肝星細胞を標的とした細胞表面抗原の樹立2017
- Author(s)
  吹田安佐詠, 松原三佐子, 松原勤, 池田一雄, 河田則文
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] C型慢性肝疾患に対するDAA治療前後の肝病理組織所見の変化について2017
- Author(s)
  榎本大、伊倉義弘、元山宏行、小塚立蔵、萩原淳司、藤井英樹、打田佐和子、森川浩安、村上善基、田守昭博、河田則文
- Organizer
  第24回日本門脈圧亢進症学会総会
- Data Source
  KAKENHI-PROJECT-16K09369
[Presentation] DAA治療による肝線維化改善効果：非侵襲的評価、病理学的検討を含めて2017
- Author(s)
  榎本大、村上善基、河田則文
- Organizer
  第21回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-16K09369
[Presentation] C型慢性肝疾患に対するDAA治療前後の短期的肝線維化改善効果について2017
- Author(s)
  榎本大、田守昭博、河田則文
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09369
[Presentation] グロビンファミリーの第4のタンパク質であるcytoglobinは胆汁鬱滞誘発性肝障害に対して一酸化窒素調節を介して保護作用を発揮する(Cytoglobin, the fourth member of globin family, protects cholestasis induced liver injury throughout regulation of Nitric oxide)(英語)2017
- Author(s)
  Le Thi Thanh Thuy, 河田則文
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] Changes in clinical and histological parameters predictive of liver fibrosis and/or HCC development after direct-acting antiviral treatment for chronic hepatitis C2017
- Author(s)
  M Enomoto, A Tamori, R Kozuka, H Motoyama, A Hagihara, H Fujii, S Uchida-Kobayashi, H Morikawa, Y Murakami, N Kawada
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) Single Topic Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369
[Presentation] Regulation of liver carcinogenesis by high fat diet,bile acid,and antibiotics in Cygb knockout mice2017
- Author(s)
  Le Thi Thanh Thuy、Toung Thi Van Thuy、Hoang Hai、吉里勝利、河田則文
- Organizer
  第31回肝類洞壁細胞研究会学術集会
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] 肝星細胞を標的とした抗線維化治療薬の開発2017
- Author(s)
  松原三佐子, 翁良徳, 河田則文
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] ヒト肝星細胞におけるTGF-β1/Smadシグナルを介したCytoglobin発現制御機構2017
- Author(s)
  翁良徳,松原三佐子,河田則文
- Organizer
  第21回日本肝臓学会大会(JDDW2017)
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] Short-term histological evaluations after achieving a sustained virological response to direct-acting antiviral treatment for chronic hepatitis C2017
- Author(s)
  Masaru Enomoto, Akihiro Tamori, Ritsuzo Kozuka, Hiroyuki Motoyama, Atsushi Hagihara, Hideki Fujii, Sawako Uchida-Kobayashi, Hiroyasu Morikawa, Yoshiki Murakami, Yoshihiro Ikura, Norifumi Kawada
- Organizer
  68th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369
[Presentation] FGF2はCytoglobinとαSMA遺伝子発現を制御し肝星細胞の脱活性化を促進する2016
- Author(s)
  松原三佐子, 大黒敦子, 松原勤, 池田一雄, 吉里勝利, 河田則文
- Organizer
  第23回肝細胞研究会
- Place of Presentation
  大阪大学中之島センター
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-16H05290
[Presentation] C型慢性肝疾患に対するIFNフリーDAA治療前後の門脈圧に関連する検査値の変化について2016
- Author(s)
  榎本大、田守昭博、寺西優雅、元山宏行、小塚立蔵、川村悦史、萩原淳司、打田佐和子、森川浩安、村上善基、河田則文
- Organizer
  第23回日本門脈圧亢進症学会総会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市)
- Year and Date
  2016-09-09
- Invited
- Data Source
  KAKENHI-PROJECT-16K09369
[Presentation] Sequential therapy with short-term entecavir followed by interferon in chronic hepatitis B patients2016
- Author(s)
  M.Enomoto, A.Tamori, R.Kozuka, S.Uchida-Kobayashi, S.Fukunisi, Y.Tsuda, K.Higuchi, M.Saito, H.Enomoto, S.Nishiguchi, N.Kawada
- Organizer
  25th Conference of the Asian Pacific Associaton for the Study of the Liver (APASL)
- Place of Presentation
  Grand Prince Hotel New Takanawa, Minato-ku, Tokyo, Japan
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461006
[Presentation] Changes in NS3/4A and NS5A resistance-associated variants of hepatitis C virus after treatment failure with direct-acting antiviral(s)2016
- Author(s)
  Hai H, Yoshida K, Tamori A, Enomoto M, Morikawa H, Kozuka R, Teranishi Y, Motoyama H, Kawamura E, Hagihara A, Murakami Y, Thuy LTT, Kawada N
- Organizer
  AASLD 2016 Annual Meeting
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2016-11-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860522
[Presentation] Promotion of intra-hospital referral of hepatitis B and C virus carriers to hepatology specialists by electronic medical record-based alert system: a case study at a university hospital2016
- Author(s)
  M. Enomoto, S. Uchida-Kobayashi, H. Fujii, A. Iida-Ueno, H. Motoyama, R. Kozuka, A. Hagihara, E. Kawamura, H. Morikawa, Y. Murakami, A. Tamori, N. Kawada
- Organizer
  24th United European Gastroenterology Week (UEGW)
- Place of Presentation
  ウイーン（オーストリア）
- Year and Date
  2016-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09369
[Presentation] 当院および関連施設におけるC型肝炎ウイルス感染者の拾い上げに向けた取り組み2016
- Author(s)
  榎本大、森川浩安、河田則文
- Organizer
  第41回日本肝臓学会東部会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-12-08
- Data Source
  KAKENHI-PROJECT-16K09369
[Presentation] エンテカビル効果不良のHBeAg陽性B型慢性肝疾患に対するHBワクチン併用の試み　無作為比較試験2015
- Author(s)
  榎本大, 木岡清英, 田守昭博, 寺西優雅, 小塚立蔵, 元山宏行, 川村悦史, 萩原淳司, 打田佐和子, 森川浩安, 村上善基, 河田則文
- Organizer
  第41回日本肝臓学会西部会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25461006
[Presentation] エンテカビル効果不良の難治性B型慢性肝疾患の特徴とその対策2015
- Author(s)
  榎本大, 田守昭博, 河田則文
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本ほか(熊本県熊本市)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25461006
[Presentation] B型慢性肝炎に対する短期エンテカビル先行投与後/PEG-IFN sequential療法の有効性2015
- Author(s)
  榎本大, 田守昭博, 小塚立蔵, 打田佐和子, 福西新弥, 津田泰宏, 樋口和秀, 齋藤正紀, 榎本平之, 西口修平, 河田則文
- Organizer
  第19回日本肝臓学会大会
- Place of Presentation
  グランドプリンスホテル新高輪ほか（東京都港区）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25461006
[Presentation] Evolution of hepatic fibrosis reserch2015
- Author(s)
  Kawada N
- Organizer
  Asian　Pacific　Association　for　the　Study　of　the　Liver
- Place of Presentation
  Istanbul (Turkey)
- Year and Date
  2015-03-13
- Invited
- Data Source
  KAKENHI-PROJECT-25293177
[Presentation] Loss of Cytoglobin Exacerbates Liver Fibrosis and Cancer Development in Steatohepatitis by Activating the Oxidative Stress Pathway2015
- Author(s)
  Le, Thuy T、Matsumoto, Yoshinari、Tuong Thi Van Thuy、Hoang Hai、Yoshizato, Katsutoshi、Kawada, Norifumi
- Organizer
  American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco(U S A)
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293177
[Presentation] MICA SNP, but not DEPDC5, PNPLA3 and HCP5 SNPs, is associated with chronic hepatitis C-related hepatocellular carcinoma2015
- Author(s)
  Hoang Hai, Akihiro Tamori, Kanako Yoshida, Atsushi Hagihara, Etsushi Kawamura, Sawako K. Uchida, Hiroyasu Morikawa, Masaru Enomoto, Yoshiki Murakami, Thuy T. Le, Norifumi Kawada.
- Organizer
  AASLD Annual Meeting.
- Place of Presentation
  サンフランシスコ(アメリカ合衆国)
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860522
[Presentation] 慢性肝疾患における肝線維化バイオマーカーとしてのmiR-222の有用性2013
- Author(s)
  河田則文, 小川智弘, 榎本大, 藤井英樹, 村上善基, 吉里勝利, 池田一雄
- Organizer
  第50回日本臨床分子医学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-25461006
[Presentation] 前向き登録例の長期経過からみたHBV再活性化対策の現状2013
- Author(s)
  田守昭博, 榎本大, 河田則文
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京（グランドプリンスホテル新高輪）
- Data Source
  KAKENHI-PROJECT-25461006
[Presentation] B型慢性肝炎に対するPEG-IFNの早期抗ウイルス効果:Sequential療法も含めて2013
- Author(s)
  榎本大, 田守昭博, 河田則文
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京（グランドプリンスホテル新高輪）
- Data Source
  KAKENHI-PROJECT-25461006
[Presentation] Cytoglobin as a novel tumor suppressor in the liver2011
- Author(s)
  Kawada N
- Organizer
  Le TT. AASLD
- Place of Presentation
  サンフランシスコ、USA
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21390232
[Presentation] Indication of the Activation of Stellate Cells and the Progression of Liver Fibrosis by MicroRNA-2222011
- Author(s)
  Enomoto M, Ogawa T, Iizuka M, Fujii H, Tamori A, Yoshizato K, Ikeda K, Kawada N
- Organizer
  62^<nd> Annual Meeting of the American Association for the Study of Liver Diseases(AASLD)
- Place of Presentation
  San Francisco, CA
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] Indication of the Activation of Stellate Cells and the Progression of Liver Fibrosis by MicroRNA-2222011
- Author(s)
  Enomoto M, Ogawa T, Iizuka M, Fujii H, Tamori A, Yoshizato K, Ikeda K, Kawada N
- Organizer
  62^<nd> Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
- Place of Presentation
  San Francisco, CA
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] Cytoglobin as a novel tumor suppressor in the liver2011
- Author(s)
  Kawada N
- Organizer
  Le TT. AASLD
- Place of Presentation
  サンフランシスコ、USA
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-22650224
[Presentation] 肝線維化と星細胞活性化に関与するマイクロRNAの解析2011
- Author(s)
  飯塚昌司、小川智弘、関谷由美子、榎本大、吉里勝利、池田一雄、河田則文
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] 慢性肝疾患における肝線維化診断マーカーとしてのmiR-222の有用性2011
- Author(s)
  飯塚昌司、榎本大、小川智弘、藤井英樹、小林佐和子、岩井秀司、森川浩安、田守昭博、河田則文
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] 慢性肝疾患における肝線維化バイオマーカーとしてのマイクロRNAの有用性2011
- Author(s)
  榎本大、小川智弘、河田則文
- Organizer
  第39回日本肝臓学会西部会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] C型慢性肝炎患者における肝線維化診断マーカーとしてのマイクロRNAの有用性2011
- Author(s)
  小川智弘、榎本大、河田則文
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] リバビリン投与量と貧血程度からみたペグインターフェロン・リバビリン療法の抗ウイルス効果予測2010
- Author(s)
  田守昭博、黒岡浩子、藤井英樹、小林佐和子、岩井秀司、森川浩安、榎本大、坂口浩樹、木岡清英、倉井修、岡博子、河田則文
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形市双葉町・山形テルサ
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] Update of cytoglobin, the newest member of globin that was discovered from the stellate cell2010
- Author(s)
  Kawada N
- Organizer
  International Society of Hepatic Sinusoidal Research
- Place of Presentation
  Pasadena, CA, USA(招待講演)
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-22650224
[Presentation] セロタイプ2型に対するペグインターフェロン・リバビリン療法の治療期間とSVR率2010
- Author(s)
  山口康徳、田守昭博、藤井英樹、小林佐和子、岩井秀司、森川浩安、榎本大、坂口浩樹、木岡清英、倉井修、岡博子、河田則文
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形市双葉町・山形テルサ
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] Update of cytoglobin, the newest member of globin that was discovered from the stellate cell2010
- Author(s)
  Kawada N
- Organizer
  International Society of Hepatic Sinusoidal Research
- Place of Presentation
  Pasadena, CA, USA(招待講演)
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-21390232
[Presentation] Changes in sequences of core region, ISDR and IRRDR of the HCV genome during interferon alpha and ribavirin therapy2010
- Author(s)
  Kozuka R, Enomoto M, Hagihara A, Fujii H, Kobayashi S, Iwai S, Morikawa H, Tamori A, Kawada N
- Organizer
  7th APASL Single Topic Conference
- Place of Presentation
  千葉市美浜区・幕張メッセ
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] ペグインターフェロン・リバビリン療法におけるリバビリン血中濃度と治療期間延長効果の検討2009
- Author(s)
  黒岡浩子、田守昭博、小林佐和子、岩井秀司、森川浩安、榎本大、倉井修、木岡清英、坂口浩樹、岡博子、羽生大記、塩見進、河田則文
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] Pathogenetic Mechanisms of Liver Damage and Fibrosis2009
- Author(s)
  Kawada N
- Organizer
  UEGW2009
- Place of Presentation
  コペンハーゲンデンマーク
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-21390232
[Presentation] 難治性C型肝炎例に対するペグインターフェロン(Peg-IFN)・リバビリン再治療による抗ウイルス効果2009
- Author(s)
  田守昭博、小林佐和子、岩井秀司、森川浩安、榎本大、坂口浩樹、木岡清英、岡博子、河田則文
- Organizer
  第95回日本消化器病学会総会
- Place of Presentation
  札幌
- Year and Date
  2009-05-07
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] Genotype 1bのC型慢性肝炎に対するPEG-IFN-α/リバビリン投与期間の個別化について:リアルタイムPCRによるresponse-guided therapyの再評価2009
- Author(s)
  中屋美香、榎本大、林健博、遠山まどか、藤井英樹、小林佐和子、岩井秀司、森川浩安、田守昭博、坂口浩樹、羽生大記、塩見進、河田則文
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590856
[Presentation] HBeAg陽性B型慢性肝炎に対する核酸アナログ/IFN sequential治療後の長期経過：特にHBsAg、HBcrAgの変化について
- Author(s)
  榎本大、西口修平、河田則文
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京国際フォーラム(東京都千代田区)
- Year and Date
  2014-04-23 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25461006
[Presentation] B型慢性肝炎に対するエンテカビル/IFN sequential療法：特にPEG-IFNと従来型IFNの比較について
- Author(s)
  榎本　大、齋藤正紀、榎本平之、西口修平、津田泰宏、樋口和秀、打田佐和子、森川浩安、村上善基、田守昭博、河田則文
- Organizer
  第18回日本肝臓学会大会
- Place of Presentation
  神戸国際展示場他（神戸市中央区）
- Year and Date
  2014-10-23 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-25461006
[Presentation] Long-term outcome of sequential therapy with lamivudine followed by interferon in nucleoside-naïve, hepatitis B e antigen-positive patients with chronic hepatitis B virus genotype C infection
- Author(s)
  M. Enomoto, S. Nishiguchi, A. Tamori, S. Uchida-Kobayashi, S. Iwai, H. Morikawa, Y. Murakami, H. Jomura, S. Shiomi, N. Kawada
- Organizer
  49th Annual Meeting of the European Association for the Study of the Liver
- Place of Presentation
  London (England)
- Year and Date
  2014-04-09 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-25461006

1. SHIMAHARA Yasuyuki (30196498)

# of Collaborated Projects: 9 results

# of Collaborated Products: 7 results
2. IKEDA Kazuo (80275247)

# of Collaborated Projects: 9 results

# of Collaborated Products: 5 results
3. LE Thuy (10572175)

# of Collaborated Projects: 7 results

# of Collaborated Products: 19 results
4. YAMAOKA Yoshio (90089102)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
5. TAMORI Akihiro (30291595)

# of Collaborated Projects: 7 results

# of Collaborated Products: 51 results
6. ENOMOTO Masaru (20423874)

# of Collaborated Projects: 6 results

# of Collaborated Products: 62 results
7. YAMAMOTO Maritaka (30253298)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
8. IIMURO Yuji (30252018)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
9. MURAKAMI YOSHIKI (00397556)

# of Collaborated Projects: 5 results

# of Collaborated Products: 22 results
10. NAKAMURA Hajime (70303914)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
11. YOSHIZATO Katsutoshi (20095516)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
12. TERAJIMA Hiroaki (40314215)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. HATANO Etsuro (80359801)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. HOANG HAI (60623246)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
15. 松原三佐子 (00635120)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
16. Hideki Fujii (20382070)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
17. OGAWA Tomohiro (70448752)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
18. MOTOYAMA Hiroyuki (00573601)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
19. UYAMA Naoki (70402873)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
20. OBARA Masanobu (60132479)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. Kawamura Etsushi (60419710)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. 竹村茂一 (00322363)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
23. 松原勤 (20628698)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
24. MORITA Takashi (70150349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. KAMOHARA Yukio (50325643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. YAMAMOTO Yuzo (70281730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KANEDA Kenji (30161186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. SEKI Shuichi (50145778)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. NAKATANI Kazuki (60295699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. KASHIWAGI Akihiko (50106796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. HARA Tetsuaki (30198890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. FUJIMOTO Jiro (90199373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
33. 志賀亮子 (50382221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 藤岡ひかる (00264226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 石橋大海 (80127969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 戸次鎮宗 (50601431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 久保正二 (80221224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
38. 石川智久 (10201914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 山口桃生 (30804819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 濱島義隆 (40333900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. IWAISAKO keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. TANAKA shogo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. KINOSHITA masahiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. ITO tokuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. DAIKOKU atsuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. ODAGIRI naoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. TAKADA sayuri

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. HIGUCHI moe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. FUJIWARA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. OHFUJI Satoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. YONEDA Masato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. ABE Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. KORENAGA Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 松原三佐子(佐藤三佐子)

# of Collaborated Projects: 0 results

# of Collaborated Products: 15 results
55. 西本尚樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 茶山一彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 中島淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 今城健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 小谷晃平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWADA Norifumi 河田 則文

KAWADA Norihumi 河田 則文

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肝細胞のがん化における細胞間相互作用を介した星細胞の役割Principal Investigator

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活性化星細胞はサイトグロビンを介して肝細胞のがん化に直接的に関与するか？Principal Investigator

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Development of anti-fibrotic therapy for liver disease by establishing technologies that regulate cytoglobin expression in hepatic stellate cellsPrincipal Investigator

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Involvement of Cytoglobin expressed in hepatic stellate cells in the development of cancer derived from inflamed liver.Principal Investigator

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癌微小環境形成におけるサイトグロビン陽性あるいは陰性筋線維芽細胞の役割Principal Investigator

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KAWADA Norifumi 河田則文

KAWADA Norihumi 河田則文