Terajima Hiroaki 寺嶋宏明

… Alternative Names

Researcher Number	40314215
External Links
Affiliation (Current)	2019: 公益財団法人田附興風会, 医学研究所第1研究部, 研究主幹
Affiliation (based on the past Project Information) *help	2013 – 2018: 公益財団法人田附興風会, 医学研究所第1研究部, 研究主幹 2001 – 2003: Kyoto University, Medicine, Lecturer, 医学研究科, 講師 2000 – 2003: 京都大学, 医学研究科, 助手 2002: 京都大学, 医学研究科, 助教授
Review Section/Research Field	Principal Investigator General surgery / Basic Section 55010:General surgery and pediatric surgery-related / Digestive surgery Except Principal Investigator General surgery / Digestive surgery
Keywords	Principal Investigator 肝虚血再灌流障害 / TLR-4 / 肝虚血再還流障害 / galectin-9 / 肝臓 / Tim-3 / 食事制限 / TIM-3 / FOXO1 / HMGB-1 … More Except Principal Investigator ROCK / 肝微小循環 / 生体顕微鏡 / Rho kinase inhibitor / hepatic microcirculation / hepatic stellate cell / 肝不全 / Rho kinase阻害剤 / 虚血再潅流障害 / 星細胞 / NKH477 / Trichostatin A / Y-27632 / enndotoxin / Liver failure / 類洞 / Liver fibrosis / hDAF / PEG10 / エンドトキシン / 肝線維化 / CHAP31 / ischemia / Intravital microscopyu / SIAH1 / 肝障害 / 人工肝臓 / 遺伝子導入ブタ / LOH / PDTC / DAF / FR901228 / reperfusion injury / 肝切除 / 体外灌流 / Heat shock protein / 肝虚血再潅流障害 / liver assist device / 補体抑制蛋白 / 遺伝子発現 / Kupffer cell / ischemia-reperfusion injury / hepatic sinusoidal cells / HSP / ミルリノン / CD8^+asialo GM1^+ T細胞 / PDEIII inhibitor / 肝細胞癌 / TapMan PCR / 抗原提示 / レトロウィルス / 同種皮膚移植 / Xenoperfusion / 分子シャペロン / 異種免疫反応 / extracorperal live perfusion / 抗asialo GM1抗体 / transgenic pig / N-アセチルシステイン / Stress response / intravital microscopy / Hepatocellular carcinoma / Liver protection / 遺伝子導入 / IgY / Gene transduction / 肝阻血再灌流障害 / HDAC / protein kinase A / baboon / 補体 / HO-1 / PDEIII阻害剤 / 肝硬変 / 異種反応性自然抗体 / Lymph node metastasis / cirrhosis / 溶血 / Defense system / 異種灌流 / Histone deacetylase / 肝虚血再灌流障害 / hepatic sinusoidal blood flow / リンパ節転移 / N-acetylcisteine / 肝繊維化 / 肝保護 / liver failure / リンパ球表面抗原 / 虚血再灌流障害 / adenylate cyclase stimulator / Olprinone / Gene expression / オルプリノン / 異種肝臓 / ヒヒ / ストレス応答 / 肝類洞血流 / Complement / 生体防御 / チオレドキシン / Gastric cancer / Liver / alyマウス / Kupffer細胞 / cAMP / 肝臓 / 二次的リンパ組織 / 再発 / Alloreactive antibody / マイクロアレイ / PDE-III inhibitor / 細胞内シグナル伝達 / PDE / Rucurrence / Transgenic pig / xenogeneic liver / 肝腺維化 / 二次リンパ組織 / PREV / フローサイトメトリー / 肝類洞壁細胞 / ROCK阻害剤 / thioredoxin / 急性肝不全 / 体外異種肝灌流 / ブタ内因性レトロウイルス / 肝癌細胞 / hepatectomy / ブタ / cvclic AMP / 胃癌 / レトロウイルス / 肝微小環境 / Milrinone / 類洞壁細胞 / TaqMan PCR / cDNA microarray / molecular chaperon / 体外肝灌流 / TrichostatinA Less

食事制限による肝虚血再還流障害の制御機構の解明Principal InvestigatorOngoing
- Principal Investigator
  
  寺嶋宏明
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The Tazuke Kofukai
トロンボモジュリンによる肝虚血再灌流障害の抑制効果の解明Principal InvestigatorOngoing
- Principal Investigator
  
  寺嶋宏明
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The Tazuke Kofukai
The elucidation of novel T cell function in innate immunity-dominated liver tissue damage.Principal Investigator
- Principal Investigator
  
  TERAJIMA Hiroaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  The Tazuke Kofukai
Development of perioperative management for hepatic resection based on the stellate cell function
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Research of the intracellular transmission mechanism of the information concerning stress response
- Principal Investigator
  
  YAMAMOTO Yuzo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Akita University
  Kyoto University
Resarch on trial to suppress surgical in cirrhotic liver by modulating activation of hepatic sinusoidal cells.
- Principal Investigator
  
  HASEGAWA Suguru, 山岡義生
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
抗原堤示の場としての二次的リンパ組織の意義の解明と免疫寛容誘導への基礎的検討
- Principal Investigator
  
  IWAO Ikai
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
The research to establish the orader-made therapy system for hepatocellular carcinoma patients by use of genome-wide microarray database
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Regulation of hepatic micro circulation by hepatic stellate cell-Application of NAC to liver failure
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
The research for the amplification of stress response by modification of the nucleosomal conformation
- Principal Investigator
  
  YAMAMOTO Yuzo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Strategy for Liver Failure by Regulating Hepatic Microcirculation through Hepatic Stellate Cell Activatity
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
The investigation of the mechanism of xenogeneic immunoreaction and its control…Examination from the organ specificity of the liver in xenotrnaplantation…
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Infectious and immunological evaluation of xenogeneic extracorporeal liver perfusion and preclinical study
- Principal Investigator
  
  YAMAOKA Yoshiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY

All 2017 2015 2003 2002

All Journal Article Presentation

[Journal Article] Thrombomodulin Attenuates Inflammatory Damage Due to Liver Ischemia and Reperfusion Injury in Mice in Toll-Like Receptor 4-Dependent Manner2017
- Author(s)
  K. Kadono, Y. Uchida, H. Hirao, T. Miyauchi, T. Watanabe, T. Iida, S. Ueda, A. Kanazawa, A. Mori, H. Okajima, H. Terajima, S. Uemoto
- Journal Title
  
  American Journal of Transplantation
  
  Volume: 17 Pages: 69-80
- DOI
  10.1111/ajt.13991
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24111009, KAKENHI-PROJECT-15K10041
[Journal Article] The protective function of galectin-9 in liver ischemia and reperfusion injury in mice2015
- Author(s)
  Hirofumi Hirao, Yoichiro Uchida, Kentaro Kadono, Hirokazu Tanaka, Toshiro Niki, Akira Yamauchi, Koichiro Hata, Takeshi Watanabe, Hiroaki Terajima, Shinji Uemoto
- Journal Title
  
  Liver transplantation
  
  Volume: 21 Pages: 968-981
- DOI
  10.1002/lt.24159
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10177, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-25670590, KAKENHI-PLANNED-24111009
[Journal Article] Reduction of hepatic ischemia/reperfusion-induced injury by a specifi ROCK/Rho kinase inhibitor Y-27632.2003
- Author(s)
  F.Ikeda, H.Terajima, Y.Shimahara, T.Kondo, Y.Yamaoka
- Journal Title
  
  J Surg Res 109(2)
  
  Pages: 155-160
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Journal Article] Significance of serum type IV collagen level of hepatectomized patients with chronic liver damage.2002
- Author(s)
  Y.Shimahara, N.Yamamoto, N.Uyama, H.Okuyama, H.Momoi, T.Kamikawa, H.Terajima, Y.Iimuro, Y.Yamamoto, I.Ikai, F.Kushihata, H.Kiyochi, N.Kobayashi, Y.Yamaoka
- Journal Title
  
  World J Surg 26(4)
  
  Pages: 451-456
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Presentation] トロンボモジュリンによる肝虚血再灌流障害の改善とその作用機序の解明2017
- Author(s)
  門野賢太郎、内田洋一朗、平尾浩史、宮内智之、堀口雅史、上田修吾、金澤旭宣、寺嶋宏明、岡島英明、上本伸二
- Organizer
  第117回日本外科学会総会
- Data Source
  KAKENHI-PROJECT-15K10041
[Presentation] 肝虚血再灌流障害と自然免疫の新しいメカニズムの解明―T cell Macrophage Cross-Talk―2015
- Author(s)
  内田洋一朗、平尾　浩史、門野　賢太郎、田中　宏和、吉冨　摩美、飯田　拓、上田　修吾、金澤　旭宣、上本　伸二、寺嶋　宏明
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-25670590
[Presentation] 当科における胆道癌に対する肝膵同時切除の治療成績の検討2015
- Author(s)
  内田洋一朗、寺嶋宏明、松原弘侑、後藤徹、岩村宣亜、飯田拓
- Organizer
  第27回肝胆膵外科学会
- Place of Presentation
  ホテルグランパシフィック LE DAIBA （東京都港区）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-15K10041

1. YAMAOKA Yoshiro (90089102)

# of Collaborated Projects: 10 results

# of Collaborated Products: 2 results
2. IWAO Ikai (60263084)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. YAMAMOTO Yuzou (70281730)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. YAMAMOTO Naritaka (30253298)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
5. KAWADA Norihumi (30271191)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. UCHIDA Yoichiro (30597745)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
7. SHIMAHARA Yasuyuki (30196498)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
8. 山内清明 (00291427)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 岡島英明 (20308604)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. SATOH Segi (00303834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAKAMURA Hajime (70303914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MIYAZAWA Hideaki (10323148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SATO Tsutomu (90235367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HASEGAWA Suguru (10362500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HATANO Etsurou (80359801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 飯室勇二 (30252018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 渡邊武 (40028684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. YAMAMOTO Koshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NISHIKAWA Yoshiki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 仁木敏朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Terajima Hiroaki 寺嶋 宏明

TERAJIMA Hiroaki 寺嶋 宏明

寺島 宏明 テラシマ ヒロアキ

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食事制限による肝虚血再還流障害の制御機構の解明Principal InvestigatorOngoing

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トロンボモジュリンによる肝虚血再灌流障害の抑制効果の解明Principal InvestigatorOngoing

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The elucidation of novel T cell function in innate immunity-dominated liver tissue damage.Principal Investigator

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[Journal Article] Thrombomodulin Attenuates Inflammatory Damage Due to Liver Ischemia and Reperfusion Injury in Mice in Toll-Like Receptor 4-Dependent Manner2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The protective function of galectin-9 in liver ischemia and reperfusion injury in mice2015

Terajima Hiroaki 寺嶋宏明

TERAJIMA Hiroaki 寺嶋宏明

寺島宏明テラシマヒロアキ