YAMAOKA Yoshio 山岡義生

Researcher Number	90089102
External Links
Affiliation (based on the past Project Information) *help	2003: 財団法人田附興風会, 医学研究所・北野病院, 院長 1995 – 2003: Professor, Kyoto University, 医学研究科, 教授 2002: 京都大学, 医学研究所, 教授 2000: 京都大学, 医科学研究科, 教授 1999: 京都大学, 大学院・医学研究科, 教授 … More
Review Section/Research Field	Principal Investigator Digestive surgery / General surgery Except Principal Investigator Digestive surgery / General surgery
Keywords	Principal Investigator 血中ケトン体比 / 肝移植 / 肝切除術 / 肝硬変 / Veno-Venous Bypass / 肝切除 / 拒絶反応 / 拡大肝切除 / 障害肝 / Heat shock protein … More Except Principal Investigator 肝移植 / 肝切除 / 血中ケトン体比 / 肝不全 / 星細胞 / 肝硬変 / 肝細胞 / ROCK / 肝ミトコンドリア / 生体肝移植 / 拒絶反応 / 虚血再潅流障害 / 肝線維化 / 肝再生 / 遺伝子導入 / 肝微小循環 / 人工肝臓 / 肝臓 / UW液 / 肝エネルギ-代謝 / 近赤外光分析 / 肝切除術 / 脳死 / 動脈血中ケトン体比 / 肝臓外科 / Liver / Liver transplantation / Tacrolimus / 肝癌 / NAC / 肝幹細胞 / 肝前駆細胞 / トランスジェニックマウス / 細胞外マトリックス / Liver Transplantation / Redox理論 / サイトカイン / Kupffer細胞 / 分子シャペロン / Liver failure / Liver fibrosis / 生体顕微鏡 / Rho kinase阻害剤 / hepatic stellate cell / hepatic microcirculation / Rho kinase inhibitor / 肝虚血再灌流障害 / ischemia / 人工肝 / 肝保存 / 肝移植術 / 肝機能 / 生体部分肝移植 / 急性拒絶反応 / 虚血耐性 / 低酸素 / 遺伝子治療 / 肝細胞癌 / 抗酸化剤 / PDGFレセプター / カテプシン / 蛍光励起セルソーター / 内胚葉 / アルブミン / 供培養 / 骨髄細胞 / エネルギーチャージ / AKBR / 生体ドナー / 免疫寛容 / HLA / living donor / Carbon-13 / Redox theory / Arterial ketone body ratio / liver regeneration / クレアチンキナーゼ / hepatectomy / 接着分子 / gene transfer / 虚血再灌流 / 体外灌流 / 補体 / 異種免疫反応 / Kupffer cell / Complement / 機能評価 / バイオリアクター / ブタ肝細胞培養 / Bioartificial liver / Functional evaluation / Bioreactor / N-アセチルシステイン / cirrhosis / 遺伝子導入ブタ / Transgenic pig / 細胞培養 / 共培養 / Hepatic Stellate Cell / Matrix metalloproteinase / ILK / Liver cirrhosis / ischemia-reperfusion injury / 熱ショック蛋白 / アポトーシス / hDAF / 類洞 / エンドトキシン / 肝障害 / Intravital microscopyu / Y-27632 / enndotoxin / 分化誘導 / AP-1 / NF-kB / 虚血再灌流障害 / Trichostatin A / FR901228 / CHAP31 / 間葉系細胞 / reperfusion injury / NKH477 / PDTC / エネルギ-代謝 / 移植肝 / viability / Redox state / pyridine nucleotides / fluorometry / spectro photometry / 肝潅流 / ヘモグロビン飽和度測定 / 潅流保存 / レドックス / 免疫能 / MTTassay / リンパ球SP(spontaxeous proliferation) / EBウィルス感染症 / 可溶性CD23 / H-MRI / 肝臓保存 / バイアビリティー / β_2-アドレナリンレセプター / レセプター最大結合能 / FK506結合タンパク / 移植外科 / 光ファイバー / Immunosuppression / LRLT / Tacrolimus' / 高齢者 / ドナー肝 / 熱、ショックタンパク / サイパ-サーミア / 耐性獲得 / 温熱療法 / 上皮増殖因子受容体 / 腫瘍増殖因子-α受容体 / アンチセンス / サイクリン / FKBP12 / FK506 / inorganic pyrophosphatase / ピロリン酸 / calcineurin / cis-trans peptidyl-prolyl isomerase / 蛋白精製 / N-acetyl-cysteine / reporter gene / 増殖因子 / 細胞増殖 / DNA合成 / 細胞間相互作用 / HVJ-liposome / kupffer cell / TGH-beta / 多能性幹細胞 / green fluorescent protein / 分化 / 血小板 / エネルギー代謝 / DIC / 多臓器不全 / 肝硬変症 / エネルギー代償 / アセト酢酸 / 3ヒドロキシ酪酸 / ケトン体比 / 膜電位 / Primary Nonfunction Liver / 肝グラフトのViability / 血中ケトン体比(AKBR) / Initial Non-Functioning Liver / Viability of The Liver Graft / Arterial Ketone Body Ratio / 脳死ドナ- / 生物活性 / ex situ / 甲状腺ホルモン / 代謝管理 / Redox Theory / Donor Liver Viability / Living Relared Partial Liver Transplantation / Hepatic Surgery / 組織適合性 / ウイルス感染症 / 免疫抑制剤 / immunosuppressant / Histocompatibility / Hla / 生体分光 / インドシアニングリーン / 色素クリアランス / Near infrared spectroscopy / Tissue spectroscopy / indocyanine green / 肝臓移植 / 生体NMR / 非侵襲的診断法 / ^<13>C NMR / ブドウ糖代謝 / 不全肝 / Liver mitochondria / Brain death / In vivo NMR / Non-invaside measurement / 自己肝温存 / 門脈 / 犬 / 肝容積 / ヒト / 移植肝サイズマッチング / 自己肝温存同所性部分肝移植 / 肝組織酸素化 / 門脈血流量 / 生体肝移植分肝機能 / living related liver transplanttation / auxiliary partial orthotopic liver transplantation / portal vein / canine model / liver degeneration / liver volume / clinical / リンパ球β2-アドレナリンジセプター / レセプター結合能 / EGFレセプター / 情報伝達 / 低酸素-再酸素化 / 無酸素・再酸化障害 / 上皮細胞増殖因子 / lymphicyte beta2-adrenoreceptor / receptor binding capacity / hepatic resection / hypexia / EGF receptor / sigual transduction / acute rejtction / 肝 / creatine kinase / transgenic mouse / liver / regeneration / 免疫抑制療法 / リンパ球混合試験 / タクロリムス / living related liver transplantation / immunosuppression / tolerance / mixed lymphocyte reaction / cytokines / 組織クロスマッチ / 組織抗原 / 免疫組織化学 / HLA抗原 / 白血球接着 / 急性拒絶 / ABO不適合 / 抗ドナー抗体 / Living donor liver transplantation / Tissue crossmatch / Tissue antigen / Immunohistochemistry / Rejection / Human leukocyte antigen / 肝エネルギー代謝 / 近赤外光スペクトロスコピー / 肝組織内SO2 / ICAM-1 / アデノウイルスベクター / ミオグロビン / 術後肝不全 / エンドトキシン肝障害 / liver surgery / hepatic energy metabolism / near-infrared tissue spectroscopy / ストレス蛋白 / 耐性 / クッシング現象 / stress protein / Brain-Death / Hepatic Microcirculation / Ischemia-Reperfusion / Tolerance / Cushing Phenomenon / Adhesion Molecule / 異種移植 / 塩化ガドリニウム / 補体制御因子 / 異種肝灌流 / 可溶性1型補体受容体 / Artificial liver / Extracorporeal perfusion / Xenotransplantation / Gadolinium chloride / ヒト肝細胞 / ブタ肝細胞 / ハイブリッド型人工肝臓 / ヒト肝細胞培養 / Human hepatocyte / Porcine hepatrocyte / 肝内リンパ球 / 細胞内グルタチオン / Nアセチルシステイン / チオアセタシド / N-アセチルシステイン / 細胞内グルタチン / IL-12 / グルタチオン / liver-associated lymphocyte / hepatocelluar carcinoma / intracellular glutathionl / N-acetyl cystein / thioacetamide / 肝細胞機能 / IV型コラーゲン / Liver Failure / liver Regeneration / Hepatocyte / Hepatic Extracellular Matrix / Type IV Collagen / Cell Culture / Liver Fibrosis / 肝細胞増殖 / 細胞外マトリックス(ECM) / チオアセトアミド(TAA) / インテグリン / Matrix metalloprotease / Matrix metalloprotease(MMP) / adenovirus vector / BrdU labeling index / 肝細胞増殖因子(HGF) / 肝細胞増殖開始機構 / Hepatocyte proliferation / Extracellular matrix / Thioacetamide / Integrin / geranylgeranylacetone / heat shock protein / molecular chaperone / preconditioning / ischemic tolerance / Chaperone inducer / pharmacological modulation / Geranylgeranylacetone / プレコンデショニング / シャペロン誘導剤 / 薬理学的修飾 / GGA誘導体 / 増殖性胆管炎 / アポプトーシス / 肝機能評価 / hepatic failure / proliferative cholangitis / apoptosis / 異種灌流 / 補体抑制蛋白 / 溶血 / 異種反応性自然抗体 / フローサイトメトリー / リンパ球表面抗原 / Xenoperfusion / Anti-oxidant / PDGF receptor / Catepsin / 類洞壁細胞 / ES細胞 / 肝細胞増殖因子 / 内胚葉レポーティングES細胞 / Cre / loxP / HGF / Embryonic Stem Cells / Hepatic Progenitor Cells / Endoderm / Transgenic Mice / Hepatocyte Growth Factor / Bone Marrow Cells / プレコンディショニング / NK-kB / 肝虚血耐性 / 肝虚血 / 再灌流障害 / シグナル伝達 / 熱ショック前処置 / 炎症反応 / NF-κB / Preconditioning / molecular Chaperone / Ischemic tolerance of the liver / Liver ischemia / Reperfusion injury / signal pathway / 消火器癌 / ケモカイン / 浸潤、転移 / 腫瘍間質 / 消化器癌 / gastrointestinal cancer / chemokine / invasion, metastasis / connective tissue surrounding the tumor / ずり応力 / Rac1 / 虚血再灌潅流 / アデノウイルス / shear stress / partial hepatectomy / Racl / reperfusion / ストレス応答 / HDAC / 遺伝子発現 / HSP / TrichostatinA / Stress response / Histone deacetylase / Gene transduction / Gene expression / Heat shock protein / ヒト肝組織 / 組織再構築 / 非実質細胞 / ヒト小型肝細胞 / 1型コラーゲンシート / 類肝組織構築 / コラーゲンタイプIシート / hepatic stem cell / human liver / tissue reconstruction / hepatic progenitor cell / non-parenchymal cell / mesenchymal cell / チオレドキシン / ROCK阻害剤 / 肝繊維化 / 急性肝不全 / 肝腺維化 / thioredoxin / intravital microscopy / N-acetylcisteine / liver failure / ヒト肝幹細胞 / 肝幹細胞特異的表面抗原 / サブクローニング / human hepatic stem / progenitor cells / mesenchymal cells / specific surface marker genes / differentiation / subcloning / ミルリノン / オルプリノン / PDEIII阻害剤 / 肝保護 / 生体防御 / PDE / 肝阻血再灌流障害 / cAMP / HO-1 / cvclic AMP / protein kinase A / PDEIII inhibitor / 細胞内シグナル伝達 / 肝虚血再潅流障害 / adenylate cyclase stimulator / 肝微小環境 / Milrinone / Olprinone / PDE-III inhibitor / Liver protection / Defense system / 肝類洞壁細胞 / 肝類洞血流 / hepatic sinusoidal cells / hepatic sinusoidal blood flow / molecular chaperon / 肝広範切除 / 代謝的濃厚治療 / チトクロムa / Blood detone body ratio / Massive hepatectomy / Metabolic intensive care / Redox 理論 / 術中侵襲スコア / 根治的広範肝切除 / Redox State / score / Bio-Pump / Hepatic surgical score score / Radical extended hepatectomy / 部分肝移植 / 移植肝バイアビリテイー / レドツクス / 肝バイアビリティ- / 同所性部分肝移植 / 肝バイアビリティ / liver transplantation / partial liver transprantation / arterial ketone body ratio / liver graft viability / redox state Less

"体性"多能性幹細胞の分離・精製
- Principal Investigator
  
  中辻憲夫, 廣瀬哲朗
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Isolation and characterization of human hepatic stem/progenitor cells and reconstruction of liver tissue
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Development of perioperative management for hepatic resection based on the stellate cell function
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Establishment of a isolation and maturation system for human adult hepatic stem cells
- Principal Investigator
  
  NAKATSUJI Norio, 廣瀬哲朗
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Research of the intracellular transmission mechanism of the information concerning stress response
- Principal Investigator
  
  YAMAMOTO Yuzo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Akita University
  Kyoto University
Resarch on trial to suppress surgical in cirrhotic liver by modulating activation of hepatic sinusoidal cells.Principal Investigator
- Principal Investigator
  
  HASEGAWA Suguru, 山岡義生
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
肝細胞・肝星細胞の供培養による細胞増殖相互作用
- Principal Investigator
  
  嶌原康行
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
肝線維化疾患におけるKupffer cell選択的遺伝子治療の試み
- Principal Investigator
  
  YAMAMOTO Maritaka
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
The research to establish the orader-made therapy system for hepatocellular carcinoma patients by use of genome-wide microarray databasePrincipal Investigator
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Regulation of hepatic micro circulation by hepatic stellate cell-Application of NAC to liver failure
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
The research for the amplification of stress response by modification of the nucleosomal conformation
- Principal Investigator
  
  YAMAMOTO Yuzo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
N-acetylcysteineによる星細胞活性化の制御
- Principal Investigator
  
  嶌原康行
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
肝臓分化マーカー遺伝子の転写調節を利用した、新しい未分化肝前駆細胞分離法の確立
- Principal Investigator
  
  HIROSE Tetsuro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Strategy for Liver Failure by Regulating Hepatic Microcirculation through Hepatic Stellate Cell Activatity
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Establishment of the method for hepatocytes differentiation from embryonic stem cells in vitro
- Principal Investigator
  
  HIROSE Tetsuro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Intracellular signal pathway and ischemic tolerance of the liver in the presence of molecular - Toward the next generation of liver preconditioning
- Principal Investigator
  
  YAMAMOTO Yuzo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
A basic research for profiles of chemokines which expressed at the connective tissue surrounding gastrointestinal cancer
- Principal Investigator
  
  SATOH Seiji, 粟根雅章
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine
Role of "shear stress" in initiation of liver regeneration
- Principal Investigator
  
  IIMURO Yuji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  HYOGO COLLEGE OF MEDICINE
  Kyoto University
Activation of regeneration capacity of the cirrhotic livers based on the molecular and genetic biologyPrincipal Investigator
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
The investigation of the mechanism of xenogeneic immunoreaction and its control…Examination from the organ specificity of the liver in xenotrnaplantation…
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Aspect of Strategy for Liver Failure by Regelating Hepatic Stellate Cell Activation
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
リンパ管増生因子・増生因子レセプターから見た消化器癌リンパ節転移機構の解明Principal Investigator
- Principal Investigator
  
  山岡義生
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
上皮増殖因子受容体のアンチセンスを用いた肝癌の治療
- Principal Investigator
  
  稲本俊
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
肝再生機序及び肝硬変における未知35kDa蛋白質の重要性-その構造解析と作用の解明-
- Principal Investigator
  
  森本泰介
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Development of bioartificial liver using transgenic pig
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Infectious and immunological evaluation of xenogeneic extracorporeal liver perfusion and preclinical studyPrincipal Investigator
- Principal Investigator
  
  YAMAOKA Yoshiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
New Strategy for Liver Failure by Regulating Hepatic Extracellular Matrix
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Acceleration of liver regeneration by gene transfer with matrix metalloproteinase (MMP)-1
- Principal Investigator
  
  IIMURO Yuji, 森本泰介
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Research for artificial modulation of the stress response and active interference into the biological protective mechanism
- Principal Investigator
  
  YAMAMOTO Yuzo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
The relationship between hepatic failure following hepatectomy and induction of apoptosis and its therapeutic approach
- Principal Investigator
  
  YAMAMOTO Naritaka
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Availability of interlrulkin 12 for gene therapy of hepatomaPrincipal Investigator
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Induction of stress protein in the liver upon brain death -changes in sinusoidal microcirculation of the liver and the tolerance acquisition to the ischemia/reperfusion injury
- Principal Investigator
  
  YAMAMOTO Yuzo
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Moduration of the molecular chaperone activity to increase the safety of extended liver surgery in the damaged liver patients -- challenge by the induction of stress response and heat shock gene transfection --Principal Investigator
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Regulation of xenograft rejection for the clinical utilization of porcine livers - Inhibiton of complement cascade and Kupffer cell activation
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Development of bioartificial liver using human hepatocytes
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Immune therapy for hepatoma by redox regulation of liver associated lymphocytes
- Principal Investigator
  
  YAMAUCHI Akira
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
肝移植後のタクロリムスによる免疫抑制効果判定法確立に関する研究
- Principal Investigator
  
  SAKAI Yoshiharu, OZAKI Nobuhiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
高齢臓器提供者からの肝移植および高齢肝の再若年化の可能性
- Principal Investigator
  
  坂井義治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
ヒト肝ハイパーサーミアによる熱ショック蛋白誘導に関する研究-虚血再灌流障害に対する耐性獲得の試み
- Principal Investigator
  
  尾崎信弘
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Comparative study of immunological tolerance in the liver transplantation from cadaver and living donorPrincipal Investigator
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Research for Immunosuppressive Therapy Adjusted to Interindvidual and Chronological Variations of Graft Antigenicity in Living Donor Liver Transplantation.
- Principal Investigator
  
  TANAKA Koichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Relationship among hepatic microcirculation, metabolism and bioactive substances : Elucidation of postoperative heptaci failure
- Principal Investigator
  
  YAMAMOTO Masayuki
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
生体内留置型近赤外生体分光測定用光ファイバーの開発-肝臓外科・移植外科への応用
- Principal Investigator
  
  田中明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Non-touch isolation hepatectomy and extra-corporeal anticancer therapy for liver tumors-Feedback of surgical technique in living-related partial liver transplantation to liver surgery-Principal Investigator
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Development of the artificial liver assist device with normothermic xenoperfusion system of the whole liverPrincipal Investigator
- Principal Investigator
  
  YAMAOKA Yosio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Immunological assessment of peripheral lymphocytes of patientsafter living related liver transplantation
- Principal Investigator
  
  TANAKA Koichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Comperative study in the viability of the liver graft harvested from cadaver and living donor, evaluated by assessment of tissue oxygenation in sinusoid and oxidation of hepatocytePrincipal Investigator
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Noninvasive evaluation of the liver in brain dead donors to prevent primary non-functioning liver in transplantation : an application of ^<13>C in vivo NMR spectroscopy.
- Principal Investigator
  
  OZAWA Kazue
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
生体肝移植における移植肝容積量と自己肝温存同所性生体部分肝移植の開発に関する研究
- Principal Investigator
  
  TANAKA Koichi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Experimental Research for Regeneration of damaged Liver
- Principal Investigator
  
  UEMOTO Shinji, 本田和男
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
トランスジェニックマウスを用いた肝臓切除におけるエネルギー代謝の研究-遺伝子治療の肝臓外科への導入
- Principal Investigator
  
  TANAKA Akira
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
肝臓外科において手術侵襲を軽減する手術手技の開発Principal Investigator
- Principal Investigator
  
  山岡義生
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
多臓器不全発症機序の研究:細胞膜レセプター結合能からみた情報伝達機構障害の解析
- Principal Investigator
  
  森敬一郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Developmet of Clye cleavano with near-infrared tissue spectroscopy
- Principal Investigator
  
  TANAKA Akira
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
生体部分肝移植の確立-Redox理論の発展とその応用
- Principal Investigator
  
  小澤和恵
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
肝移植における肝臓と免疫の相互作用についての基礎的及び臨床的解析
- Principal Investigator
  
  INAMOTO Takashi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
ポータブル血中ケトン体測定器の試作Principal Investigator
- Principal Investigator
  
  山岡義生
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
H-NMRによるドナー肝バイアビリティーの無侵襲的評価とその生化学的研究
- Principal Investigator
  
  田中明
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Perioperative management in clinical liver traus plantationPrincipal Investigator
- Principal Investigator
  
  YAMAOKA Yoshio, 小澤和恵
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University Faculty of Medicine, The Secoud Department of Surgery
近赤外吸収スペクトラムを利用した肝組織中ヘモグロビン飽和度測定装置の開発
- Principal Investigator
  
  小澤和恵
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
人工肝補助装置を用いた脳死肝,屍体肝viability向上に対する研究
- Principal Investigator
  
  嶌原康行
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Postoperative management and immunological study in living related liver trausplantation
- Principal Investigator
  
  TANAKA Koichi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Surgical Treatment for Hepatic Malignancy, In Situ and Ex SituPrincipal Investigator
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
UW液を用いた人工肝の効率改善に関する研究
- Principal Investigator
  
  島原康行
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Evaluation of liver graft viability in human liver transplantation.
- Principal Investigator
  
  OZAWA Kazue
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University
Use of Redox theory in the perioperative metabolic support and the treatment in liver surgery and transplant.
- Principal Investigator
  
  OZAWA Kazue
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
遠心型ポンプを用いた人工肝の効率改善に関する研究
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
生着率の向上を目的とした移植肝viabilityの非侵襲的判定装置の開発
- Principal Investigator
  
  小澤和恵
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Hepatic Resection Using in-situ Cold Perfusion Under Total Vascular ExclusionPrincipal Investigator
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
肝不全の診断と治療のためのRedox全自動連続分析装置の試作研究
- Principal Investigator
  
  小澤和恵
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Quantification of operative stress for radical extended hepatectomy
- Principal Investigator
  
  OZAWA Kazue
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Assessment of graft viability after liver transplantation
- Principal Investigator
  
  TANAKA Koichi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
血小板エネルギーチャージの全身代謝機能評価における意義
- Principal Investigator
  
  森敬一郎
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
外科手術後の多臓器不全における代謝異常と細胞障害の分析Principal Investigator
- Principal Investigator
  
  山岡義生
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
簡便性と安全性の向上を目的とした生物学的肝補助装置の改良Principal Investigator
- Principal Investigator
  
  山岡義生
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
肝不全の診断と治療のための血中ケトン体比高感度連続自動分析装置の試作研究
- Principal Investigator
  
  小澤和恵
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Retional management of patients with hepatic malignancies for redical massive hepatectomy - with special reference to metabolic internsive care besed on "Redox theory".
- Principal Investigator
  
  OZAWA Kazue
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University

All 2003 2002 2001

All Journal Article

[Journal Article] Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice.2003
- Author(s)
  H.Okuyama, H.Nakamura, Y.Shimahara, S.Araya, N.Kawada, Y.Yamaoka, J.Yodoi
- Journal Title
  
  Hepatology 37
  
  Pages: 1015-1025
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Journal Article] Reduction of hepatic ischemia/reperfusion-induced injury by a specifi ROCK/Rho kinase inhibitor Y-27632.2003
- Author(s)
  F.Ikeda, H.Terajima, Y.Shimahara, T.Kondo, Y.Yamaoka
- Journal Title
  
  J Surg Res 109(2)
  
  Pages: 155-160
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Journal Article] Regulation of Cultured Rat Hepatocyte Proliferation by Stellate Cells.2002
- Author(s)
  Uyama-N., Shimahara-Y., Kawada-N., Seki-S., Okuyama-H., Iimuro-Y., Yamaoka-Y.
- Journal Title
  
  Journal of Hepatology 36
  
  Pages: 590-599
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13557100
[Journal Article] Significance of serum type IV collagen level of hepatectomized patients with chronic liver damage.2002
- Author(s)
  Y.Shimahara, N.Yamamoto, N.Uyama, H.Okuyama, H.Momoi, T.Kamikawa, H.Terajima, Y.Iimuro, Y.Yamamoto, I.Ikai, F.Kushihata, H.Kiyochi, N.Kobayashi, Y.Yamaoka
- Journal Title
  
  World J Surg 26(4)
  
  Pages: 451-456
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Journal Article] Regulation of Cultured Rat Hepatocyte Proliferation by Stellate Cells.2002
- Author(s)
  N.Uyama, Y.Shimahara, N.Kawada, S.Seki, H.Okuyama, Y.Iimuro Y.Yamaoka
- Journal Title
  
  J Hepatol 36
  
  Pages: 590-599
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Journal Article] N-acetyl cysteine inhibits PDGF-dependent proliferation of primary cultured o rat hepatic stellate cells through degradation of PDGF receptor and attenuates progress of liver fibrosis in rat models.2001
- Author(s)
  Okuyama-H., Kawada-N., Shim ahara-Y., Uyama-N., Yamaoka-Y.
- Journal Title
  
  Cells of Hepatic Sinusoid 8
  
  Pages: 284-276
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13557100
[Journal Article] The interaction between hepatocytes and stellate cells on individual cell proliferation and differentiation2001
- Author(s)
  Uyama-N., Kawada-N., Ikuyama-H., Iimuro-Y., Kaneda-K., Shimahara-Y., Yamaoka-Y.
- Journal Title
  
  Cells of Hepatic Sinusoid 8
  
  Pages: 51-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13557100
[Journal Article] Regulation of cell growth by redox-mediated extracellular proteolysis of platelet-derived growth factor receptor beta.2001
- Author(s)
  Okuyama, -H., Shimahara, -Y., Kawada, -N., Seki, -S., Kristensen, -D.-B., Yoshizato, -K., Uyama, -N., Yamaoka,-Y.
- Journal Title
  
  J-Biol-Chem. 276(30)
  
  Pages: 28274-28280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13557100

1. SHIMAHARA Yasuyuki (30196498)

# of Collaborated Projects: 26 results

# of Collaborated Products: 7 results
2. YAMAMOTO Yuzo (70281730)

# of Collaborated Projects: 18 results

# of Collaborated Products: 0 results
3. OZAWA Kazue (00026858)

# of Collaborated Projects: 18 results

# of Collaborated Products: 0 results
4. IKAI Iwao (60263084)

# of Collaborated Projects: 17 results

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5. TANAKA Kouichi (20115877)

# of Collaborated Projects: 16 results

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6. MORI Keiichiro (80159186)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
7. TANAKA Akira (00240820)

# of Collaborated Projects: 12 results

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8. INAMOTO Takashi (10135577)

# of Collaborated Projects: 12 results

# of Collaborated Products: 0 results
9. OZAKI Nobuhiro (50211818)

# of Collaborated Projects: 12 results

# of Collaborated Products: 0 results
10. YAMAMOTO Maritaka (30253298)

# of Collaborated Projects: 11 results

# of Collaborated Products: 1 results
11. MORIMOTO Taisuke (60135910)

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# of Collaborated Products: 0 results
12. IIMURO Yuji (30252018)

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# of Collaborated Products: 0 results
13. TERAJIMA Hiroaki (40314215)

# of Collaborated Projects: 9 results

# of Collaborated Products: 2 results
14. KAWADA Norihumi (30271191)

# of Collaborated Projects: 7 results

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15. HONDA Kazuo (00209321)

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16. SAKAI Yoshiharu (60273455)

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17. YAMAUCHI Akira (00291427)

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18. NAKATSUJI Norio (80237312)

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19. INOMATA Yukihiro (50193628)

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20. UEMOTO Shinji (40252449)

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21. HIROSE Tetsuro (00314279)

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22. SATOH Seiji (00303834)

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23. ピッケルマイヤールドル

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24. KAMIYAMA Yasuo (90127069)

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25. IWATA Hiroo (30160120)

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# of Collaborated Products: 0 results
26. TAKABAYASHI Arimichi (00226911)

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# of Collaborated Products: 0 results
27. YAMAMOTO Masayuki (30158307)

# of Collaborated Projects: 2 results

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28. FUKUMOTO Manabu (60156809)

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29. 粟根雅章 (80303832)

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30. HIRAO Konomu

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31. MORI Naoki

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# of Collaborated Products: 0 results
32. 宇野静夫

# of Collaborated Projects: 2 results

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33. ルドルフピッケルマイヤ

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34. YAMABE Hirohiko (00135592)

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# of Collaborated Products: 0 results
35. MORIKAWA Shigehiro (60220042)

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36. INUBUSHI Toshiro (20213142)

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37. KODAMA Masashi (50079836)

# of Collaborated Projects: 1 results

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38. SAWASAKI Yoshio (90092410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. YODOI Junji (80108993)

# of Collaborated Projects: 1 results

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40. KANAI Michiyuki (00322652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. FUJIMOTO Jiro (90199373)

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# of Collaborated Products: 0 results
42. MITAKA Toshihiro (50231618)

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# of Collaborated Products: 0 results
43. UESUGI Takehiko (20362494)

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44. NAKAMURA Hajime (70303914)

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# of Collaborated Products: 1 results
45. MIYAZAWA Hideaki (10323148)

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46. SATO Tsutomu (90235367)

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47. HASEGAWA Suguru (10362500)

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48. HATANO Etsurou (80359801)

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49. UKIKUSA Minoru (60168672)

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50. 折井豊 (60028149)

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52. 湊長博 (40137716)

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53. 阿曽沼克弘 (40202626)

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54. OKA Koichi

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55. TAKENAKA Yoshinori

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56. HAMMER Claus

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57. MESSMER Konard

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58. YAMAMOTO Koshi

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59. NISHIKAWA Yoshiki

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60. OKETANI Kiyoshi

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61. 長村俊彦

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62. 北岸恵子

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63. 鍛利幸

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64. 柳父宣治

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65. 澤村義巳

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66. 森正昭

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67. 田村康一

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68. 青木吉平

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69. PICHLMAYR Rudolf

# of Collaborated Projects: 1 results

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70. RUDOY Pichlmayr

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71. ウオニカイトクルト

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72. WONIGEIT Kurt

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73. PICHLMAYR Rudorf

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74. PICHLMAYR Ru

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75. WONIGEIT Kur

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76. ブルームエダ T.

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77. BLOOM Eda T

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78. MESSMER Konr

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79. BLOOM Eda T.

# of Collaborated Projects: 1 results

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80. PLATT Jeffre

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMAOKA Yoshio 山岡 義生

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Resarch on trial to suppress surgical in cirrhotic liver by modulating activation of hepatic sinusoidal cells.Principal Investigator

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The research to establish the orader-made therapy system for hepatocellular carcinoma patients by use of genome-wide microarray databasePrincipal Investigator

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YAMAOKA Yoshio 山岡義生