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USHIJIMA Kentaro  牛島 健太郎

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… Alternative Names

牛島 健太郎  ウシジマ ケンタロウ

USHIJIMA Kentarou  牛島 健太郎

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Researcher Number 70448843
Other IDs
Affiliation (Current) 2025: 山陽小野田市立山口東京理科大学, 薬学部, 教授
2025: 自治医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help 2019 – 2023: 山陽小野田市立山口東京理科大学, 薬学部, 教授
2013 – 2019: 自治医科大学, 医学部, 講師
2011: 自治医科大学, 医学部, 講師
2010: 自治医科大学, 医学部, 助教
2007 – 2008: Jichi Medical University, 医学部, 助教
Review Section/Research Field
Principal Investigator
Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Basic Section 48030:Pharmacology-related / General physiology
Except Principal Investigator
Applied pharmacology / Medium-sized Section 48:Biomedical structure and function and related fields / Basic Section 47060:Clinical pharmacy-related / Respiratory organ internal medicine
Keywords
Principal Investigator
時計遺伝子 / 生体リズム / 糖尿病 / うつ病 / 薬物有害反応 / 体内時計 / 細胞外小胞 / マイクロRNA / BMAL1 / バイオマーカー … More / microRNA / 変形性膝関節症 / 組織得意性 / がん細胞 / 組織特異性 / Bmal1 / 治療抵抗性 / 膵臓がん / 概日リズム / エネルギー代謝 / 臓器連関 / 前駆脂肪細胞 / 脂肪細胞分化 / インスリン感受性 / 薬物友愛反応 / 精神障害 / 培養細胞 / 視交叉上核 / 転写活性 / 遺伝子発現 / 外的ストレス / 高カロリー食 / 遺伝子発現リズム … More
Except Principal Investigator
糖尿病 / 体内時計 / 時間治療 / 生活習慣病 / 時計遺伝子 / 概日リズム / iPS細胞 / パーキンソン病 / 時間薬理学 / 経鼻投与 / αシヌクレイン / ヒトiPS細胞 / 脳ペリサイト / 血液脳関門 / 高齢者 / トランスポーター / 薬物動態 / 肥満 / 間質性肺疾患 / 間質性肺炎 / 2型糖尿病 / 血糖降下薬 / 肺傷害 / Temsirolimus / mTOR阻害薬 / 臨床薬理学 / 暁現象 / 糖新生 Less
  • Research Projects

    (12 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (11 People)
  •  Chronotherapeutic strategy for Parkinson's disease by intranasal administration of human iPS-derived brain pericytes

    • Principal Investigator
      道具 伸也
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 48:Biomedical structure and function and related fields
    • Research Institution
      Fukuoka University
  •  Elucidation of the mechanism of chondrocyte deterioration and osteoarthritis caused by disturbance of biological clock systemPrincipal Investigator

    • Principal Investigator
      牛島 健太郎
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tokyo University of Science, Yamaguchi
  •  Prediction of drug disposition into brain in elders using clusters of daily variation in gene expression

    • Principal Investigator
      藤村 昭夫
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Jichi Medical University
  •  Development of a method to overcome treatment-resistant cancers by applying organ-specific regulation of gene expression by the biological clockPrincipal Investigator

    • Principal Investigator
      Ushijima Kentaro
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Tokyo University of Science, Yamaguchi
  •  Mechanism of peripheral clock abnormalities caused by disturbance of central-peripheral tissue linkagePrincipal Investigator

    • Principal Investigator
      Ushijima Kentaro
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research)
    • Research Field
      Medical pharmacy
    • Research Institution
      Jichi Medical University
  •  Evaluation of a mechanism of lifestyle-related diseases focusing on the initiate-regulation of adipocyte differentiation by the clock systemPrincipal Investigator

    • Principal Investigator
      Ushijima Kentaro
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tokyo University of Science, Yamaguchi
      Jichi Medical University
  •  Treatment of mTOR inhibtor-induced lung disease

    • Principal Investigator
      Satoshi Washino
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Jichi Medical University
  •  Elucidation of pathophysiology and treatment strategies of peripheral clock disruption

    • Principal Investigator
      ANDO Hitoshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Kanazawa University
  •  Development for new targets of anti-depressants using biological clock-systemPrincipal Investigator

    • Principal Investigator
      Ushijima Kentaro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Jichi Medical University
  •  Development of pharmacological therapy targeting peripheral circadian clocks for treatment of type 2 diabetes

    • Principal Investigator
      ANDO Hitoshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Jichi Medical University
  •  Evaluation of a predict system of drug-induced depression by applying the circadian clock systemPrincipal Investigator

    • Principal Investigator
      USHIJIMA Kentarou
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Jichi Medical University
  •  Elucidation of the mechanism of insulin resistance based on clock genesPrincipal Investigator

    • Principal Investigator
      USHIJIMA Kentarou
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      General physiology
    • Research Institution
      Jichi Medical University

All 2023 2022 2021 2020 2019 2018 2017 2016 2013 2012 2011 2010

All Journal Article Presentation Book

  • [Book] 時間治療学-投薬のタイミングと効果-2013

    • Author(s)
      藤村昭夫、藤秀人、安藤仁、牛島健太郎
    • Total Pages
      177
    • Publisher
      日本医事新報社
    • Data Source
      KAKENHI-PROJECT-25460221
  • [Journal Article] Understanding the role of chronopharmacology for drug optimization: what do we know?2023

    • Author(s)
      Fujimura Akio、Ushijima Kentaro
    • Journal Title

      Expert Review of Clinical Pharmacology

      Volume: 16 Issue: 7 Pages: 655-668

    • DOI

      10.1080/17512433.2023.2233438

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06729, KAKENHI-PROJECT-23K06259
  • [Journal Article] Influence of renal ischemia-reperfusion injury on renal neutrophil gelatinase-associated lipocalin receptor (24p3R) in rats.2019

    • Author(s)
      Arakawa Y, Ushijima K, Tsuchiya H, Morishige JI, Mii A, Ando H, Tsuruoka SI, Fujimura A.
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 46 Issue: 12 Pages: 1166-1173

    • DOI

      10.1111/1440-1681.13129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K18954
  • [Journal Article] Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensitivity via adipocyte differentiation in ob/ob mice.2019

    • Author(s)
      1.Suzuki C, Ushijima K#, Ando H, Kitamura H, Horiguchi M, Akita T, Yamashita C, Fujimura A.
    • Journal Title

      Chronobiology International

      Volume: 印刷中 Issue: 7 Pages: 955-968

    • DOI

      10.1080/07420528.2019.1602841

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K18954, KAKENHI-PROJECT-18K14961, KAKENHI-PROJECT-17KK0198
  • [Journal Article] Effect of a dosing-time on quetiapine-induced acute hyperglycemia in mice.2017

    • Author(s)
      Kapse S, Ando H, Fujiwara Y, Suzuki C, Ushijima K, Kitamura H, Hosohata K, Kotani K, Shimba S, Fujimura A.
    • Journal Title

      J Pharmacol Sci

      Volume: 133 Issue: 3 Pages: 139-145

    • DOI

      10.1016/j.jphs.2017.02.008

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460631, KAKENHI-PROJECT-15K08594
  • [Journal Article] Daily Fasting Blood Glucose Rhythm in Male Mice: A Role of the Circadian Clock in the Liver.2016

    • Author(s)
      Ando H, Ushijima K, Shimba S, Fujimura A.
    • Journal Title

      Endocrinology

      Volume: 157 Issue: 2 Pages: 463-9

    • DOI

      10.1210/en.2015-1376

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08594
  • [Journal Article] Indirect effects of glucagon-like peptide-1 receptor agonist exendin-4 on the peripheral circadian clocks in mice.2013

    • Author(s)
      Ando H, Ushijima K, Fujimura A.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e81119-e81119

    • DOI

      10.1371/journal.pone.0081119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590666
  • [Journal Article] Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain2012

    • Author(s)
      Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo S
    • Journal Title

      Mol Pharmacol

      Volume: (in press) Issue: 2 Pages: 264-270

    • DOI

      10.1124/mol.112.079079

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790166
  • [Journal Article] Influence of time-restricted feeding schedule on daily rhythm of abcb1a gene expression and its function in rat intestine.2010

    • Author(s)
      Hayashi Y, Ushijima K, et al.
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 335 Pages: 418-423

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790166
  • [Journal Article] Influence of time-restricted feeding schedule on daily rhythm of abcb1a gene expression and its function in rat intestine2010

    • Author(s)
      Hayashi Y, Ushijima K, Ando H, Yanagihara H, Ishikawa E, Tsuruoka S, Sugimoto K, Fujimura A
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 335(2) Issue: 2 Pages: 418-23

    • DOI

      10.1124/jpet.110.170837

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790166
  • [Presentation] 時計遺伝子BMAL1に着目した変形性関節症の疾患バイオマーカー探索2023

    • Author(s)
      和田由喜世、鶴留優也、堀口道子、牛島健太郎
    • Organizer
      第40回日本薬学会九州山口支部大会
    • Data Source
      KAKENHI-PROJECT-23K06259
  • [Presentation] 不適切な食事タイミングが引き起こす肝臓内脂質蓄積に、マイクロRNA発現異常が関与する2022

    • Author(s)
      牛島健太郎、鶴留優也、和田由喜世、堀口道子、藤村昭夫
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-19K07327
  • [Presentation] 不適切な食事タイミングが引き起こす肝臓脂質異常症の解析2021

    • Author(s)
      鶴留優也、堀口道子、藤村昭夫、牛島健太郎
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-19K07327
  • [Presentation] 研究は孤独にあらず。医学部・附属病院での研究生活で得たもの2020

    • Author(s)
      牛島 健太郎
    • Organizer
      第14回次世代を担う若手医療薬科学シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07327
  • [Presentation] ファーマコメトリクスの展開と臨床薬理学研究者2020

    • Author(s)
      牛島健太郎、大柿景子、大友慎也
    • Organizer
      第41回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07327
  • [Presentation] 脂肪細胞分化における時計遺伝子Dbpの関与2018

    • Author(s)
      鈴木智理、牛島健太郎、安藤仁、北村広子、秋田智后、今井靖、山下親正、藤村昭夫
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K18954
  • [Presentation] 体内時計システムを活用した臨床薬理学研究ならびに毒性学研究2017

    • Author(s)
      牛島健太郎、安藤仁、藤村昭夫
    • Organizer
      第44回 日本毒性学会学術年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K18954
  • [Presentation] 生体リズム研究の医療応用と3Rの促進に向けた取り組み2016

    • Author(s)
      牛島健太郎、安藤仁、藤村昭夫
    • Organizer
      第29回日本動物実験代替法学会
    • Place of Presentation
      九州大学百年記念講堂(福岡市)
    • Year and Date
      2016-11-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K18954
  • [Presentation] 「生物時計を基盤にした基礎・臨床橋渡し研究 (TR, rTR)」 体内時計と高血圧2013

    • Author(s)
      牛島健太郎、安藤仁、藤村昭夫
    • Organizer
      第20回日本時間生物学会学術大会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-25460221
  • [Presentation] 体内時計におよぼすExcendin-4の影響2013

    • Author(s)
      安藤 仁、牛島健太郎、藤村昭夫
    • Organizer
      日本糖尿病学会
    • Place of Presentation
      熊本ホテルキャッスル(熊本市)
    • Data Source
      KAKENHI-PROJECT-24590666
  • [Presentation] 体内時計におよぼすエキセナチドの影響2012

    • Author(s)
      安藤 仁、牛島健太郎、藤村昭夫
    • Organizer
      日本時間生物学会
    • Place of Presentation
      北海道大学学術交流会館(札幌市)
    • Data Source
      KAKENHI-PROJECT-24590666
  • [Presentation] Activating transcription factor-4によるマウスセロトニントランスポーター発現リズムの制御2012

    • Author(s)
      牛島健太郎
    • Organizer
      薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-22790166
  • [Presentation] 生体リズムと薬物の中枢神経系副作用2011

    • Author(s)
      牛島健太郎
    • Organizer
      第18回日本時間生物学会学術大会
    • Place of Presentation
      名古屋大学(名古屋)
    • Year and Date
      2011-11-25
    • Data Source
      KAKENHI-PROJECT-22790166
  • [Presentation] 体内時計システムを利用した薬物誘発性精神疾患予測法の構築2010

    • Author(s)
      牛島健太郎
    • Organizer
      第31回日本臨床薬理学会年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2010-12-03
    • Data Source
      KAKENHI-PROJECT-22790166
  • 1.  ANDO Hitoshi (50382875)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 2.  TAKAMURA Toshinari (00324111)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  Satoshi Washino (50406162)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  藤村 昭夫 (90156901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  今井 靖 (20359631)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  土屋 裕義 (80508755)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  道具 伸也 (60399186)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  田中 泰圭 (50714466)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  高田 芙友子 (70412575)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  岩尾 卓朗 (30846374)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  細畑 圭子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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