USHIJIMA Kentaro 牛島健太郎

… Alternative Names

牛島健太郎ウシジマケンタロウ

USHIJIMA Kentarou 牛島健太郎

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Researcher Number	70448843
Other IDs
Affiliation (Current)	2025: 山陽小野田市立山口東京理科大学, 薬学部, 教授 2025: 自治医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2019 – 2023: 山陽小野田市立山口東京理科大学, 薬学部, 教授 2013 – 2019: 自治医科大学, 医学部, 講師 2011: 自治医科大学, 医学部, 講師 2010: 自治医科大学, 医学部, 助教 2007 – 2008: Jichi Medical University, 医学部, 助教
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Basic Section 48030:Pharmacology-related / General physiology Except Principal Investigator Applied pharmacology / Medium-sized Section 48:Biomedical structure and function and related fields / Basic Section 47060:Clinical pharmacy-related / Respiratory organ internal medicine
Keywords	Principal Investigator 時計遺伝子 / 生体リズム / 糖尿病 / うつ病 / 薬物有害反応 / 体内時計 / 細胞外小胞 / マイクロRNA / BMAL1 / バイオマーカー … More / microRNA / 変形性膝関節症 / 組織得意性 / がん細胞 / 組織特異性 / Bmal1 / 治療抵抗性 / 膵臓がん / 概日リズム / エネルギー代謝 / 臓器連関 / 前駆脂肪細胞 / 脂肪細胞分化 / インスリン感受性 / 薬物友愛反応 / 精神障害 / 培養細胞 / 視交叉上核 / 転写活性 / 遺伝子発現 / 外的ストレス / 高カロリー食 / 遺伝子発現リズム … More Except Principal Investigator 糖尿病 / 体内時計 / 時間治療 / 生活習慣病 / 時計遺伝子 / 概日リズム / iPS細胞 / パーキンソン病 / 時間薬理学 / 経鼻投与 / αシヌクレイン / ヒトiPS細胞 / 脳ペリサイト / 血液脳関門 / 高齢者 / トランスポーター / 薬物動態 / 肥満 / 間質性肺疾患 / 間質性肺炎 / 2型糖尿病 / 血糖降下薬 / 肺傷害 / Temsirolimus / mTOR阻害薬 / 臨床薬理学 / 暁現象 / 糖新生 Less

Chronotherapeutic strategy for Parkinson's disease by intranasal administration of human iPS-derived brain pericytes
- Principal Investigator
  
  道具伸也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Fukuoka University
Elucidation of the mechanism of chondrocyte deterioration and osteoarthritis caused by disturbance of biological clock systemPrincipal Investigator
- Principal Investigator
  
  牛島健太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Prediction of drug disposition into brain in elders using clusters of daily variation in gene expression
- Principal Investigator
  
  藤村昭夫
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Jichi Medical University
Development of a method to overcome treatment-resistant cancers by applying organ-specific regulation of gene expression by the biological clockPrincipal Investigator
- Principal Investigator
  
  Ushijima Kentaro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Mechanism of peripheral clock abnormalities caused by disturbance of central-peripheral tissue linkagePrincipal Investigator
- Principal Investigator
  
  Ushijima Kentaro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Medical pharmacy
- Research Institution
  Jichi Medical University
Evaluation of a mechanism of lifestyle-related diseases focusing on the initiate-regulation of adipocyte differentiation by the clock systemPrincipal Investigator
- Principal Investigator
  
  Ushijima Kentaro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Science, Yamaguchi
  Jichi Medical University
Treatment of mTOR inhibtor-induced lung disease
- Principal Investigator
  
  Satoshi Washino
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jichi Medical University
Elucidation of pathophysiology and treatment strategies of peripheral clock disruption
- Principal Investigator
  
  ANDO Hitoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kanazawa University
Development for new targets of anti-depressants using biological clock-systemPrincipal Investigator
- Principal Investigator
  
  Ushijima Kentaro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Jichi Medical University
Development of pharmacological therapy targeting peripheral circadian clocks for treatment of type 2 diabetes
- Principal Investigator
  
  ANDO Hitoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Jichi Medical University
Evaluation of a predict system of drug-induced depression by applying the circadian clock systemPrincipal Investigator
- Principal Investigator
  
  USHIJIMA Kentarou
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Jichi Medical University
Elucidation of the mechanism of insulin resistance based on clock genesPrincipal Investigator
- Principal Investigator
  
  USHIJIMA Kentarou
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University

All 2023 2022 2021 2020 2019 2018 2017 2016 2013 2012 2011 2010

All Journal Article Presentation Book

[Book] 時間治療学－投薬のタイミングと効果－2013
- Author(s)
  藤村昭夫、藤秀人、安藤仁、牛島健太郎
- Total Pages
  177
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-25460221
[Journal Article] Understanding the role of chronopharmacology for drug optimization: what do we know?2023
- Author(s)
  Fujimura Akio、Ushijima Kentaro
- Journal Title
  
  Expert Review of Clinical Pharmacology
  
  Volume: 16 Issue: 7 Pages: 655-668
- DOI
  10.1080/17512433.2023.2233438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06729, KAKENHI-PROJECT-23K06259
[Journal Article] Influence of renal ischemia-reperfusion injury on renal neutrophil gelatinase-associated lipocalin receptor (24p3R) in rats.2019
- Author(s)
  Arakawa Y, Ushijima K, Tsuchiya H, Morishige JI, Mii A, Ando H, Tsuruoka SI, Fujimura A.
- Journal Title
  
  Clin Exp Pharmacol Physiol
  
  Volume: 46 Issue: 12 Pages: 1166-1173
- DOI
  10.1111/1440-1681.13129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18954
[Journal Article] Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensitivity via adipocyte differentiation in ob/ob mice.2019
- Author(s)
  1.Suzuki C, Ushijima K#, Ando H, Kitamura H, Horiguchi M, Akita T, Yamashita C, Fujimura A.
- Journal Title
  
  Chronobiology International
  
  Volume: 印刷中 Issue: 7 Pages: 955-968
- DOI
  10.1080/07420528.2019.1602841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18954, KAKENHI-PROJECT-18K14961, KAKENHI-PROJECT-17KK0198
[Journal Article] Effect of a dosing-time on quetiapine-induced acute hyperglycemia in mice.2017
- Author(s)
  Kapse S, Ando H, Fujiwara Y, Suzuki C, Ushijima K, Kitamura H, Hosohata K, Kotani K, Shimba S, Fujimura A.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 133 Issue: 3 Pages: 139-145
- DOI
  10.1016/j.jphs.2017.02.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460631, KAKENHI-PROJECT-15K08594
[Journal Article] Daily Fasting Blood Glucose Rhythm in Male Mice: A Role of the Circadian Clock in the Liver.2016
- Author(s)
  Ando H, Ushijima K, Shimba S, Fujimura A.
- Journal Title
  
  Endocrinology
  
  Volume: 157 Issue: 2 Pages: 463-9
- DOI
  10.1210/en.2015-1376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08594
[Journal Article] Indirect effects of glucagon-like peptide-1 receptor agonist exendin-4 on the peripheral circadian clocks in mice.2013
- Author(s)
  Ando H, Ushijima K, Fujimura A.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: e81119-e81119
- DOI
  10.1371/journal.pone.0081119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590666
[Journal Article] Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain2012
- Author(s)
  Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo S
- Journal Title
  
  Mol Pharmacol
  
  Volume: (in press) Issue: 2 Pages: 264-270
- DOI
  10.1124/mol.112.079079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790166
[Journal Article] Influence of time-restricted feeding schedule on daily rhythm of abcb1a gene expression and its function in rat intestine.2010
- Author(s)
  Hayashi Y, Ushijima K, et al.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 335 Pages: 418-423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790166
[Journal Article] Influence of time-restricted feeding schedule on daily rhythm of abcb1a gene expression and its function in rat intestine2010
- Author(s)
  Hayashi Y, Ushijima K, Ando H, Yanagihara H, Ishikawa E, Tsuruoka S, Sugimoto K, Fujimura A
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 335(2) Issue: 2 Pages: 418-23
- DOI
  10.1124/jpet.110.170837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790166
[Presentation] 時計遺伝子BMAL1に着目した変形性関節症の疾患バイオマーカー探索2023
- Author(s)
  和田由喜世、鶴留優也、堀口道子、牛島健太郎
- Organizer
  第40回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-23K06259
[Presentation] 不適切な食事タイミングが引き起こす肝臓内脂質蓄積に、マイクロRNA発現異常が関与する2022
- Author(s)
  牛島健太郎、鶴留優也、和田由喜世、堀口道子、藤村昭夫
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07327
[Presentation] 不適切な食事タイミングが引き起こす肝臓脂質異常症の解析2021
- Author(s)
  鶴留優也、堀口道子、藤村昭夫、牛島健太郎
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07327
[Presentation] 研究は孤独にあらず。医学部・附属病院での研究生活で得たもの2020
- Author(s)
  牛島　健太郎
- Organizer
  第14回次世代を担う若手医療薬科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K07327
[Presentation] ファーマコメトリクスの展開と臨床薬理学研究者2020
- Author(s)
  牛島健太郎、大柿景子、大友慎也
- Organizer
  第41回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07327
[Presentation] 脂肪細胞分化における時計遺伝子Dbpの関与2018
- Author(s)
  鈴木智理、牛島健太郎、安藤仁、北村広子、秋田智后、今井靖、山下親正、藤村昭夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K18954
[Presentation] 体内時計システムを活用した臨床薬理学研究ならびに毒性学研究2017
- Author(s)
  牛島健太郎、安藤仁、藤村昭夫
- Organizer
  第44回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K18954
[Presentation] 生体リズム研究の医療応用と3Rの促進に向けた取り組み2016
- Author(s)
  牛島健太郎、安藤仁、藤村昭夫
- Organizer
  第29回日本動物実験代替法学会
- Place of Presentation
  九州大学百年記念講堂（福岡市）
- Year and Date
  2016-11-16
- Invited
- Data Source
  KAKENHI-PROJECT-16K18954
[Presentation] 「生物時計を基盤にした基礎・臨床橋渡し研究 (TR, rTR)」　体内時計と高血圧2013
- Author(s)
  牛島健太郎、安藤仁、藤村昭夫
- Organizer
  第20回日本時間生物学会学術大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25460221
[Presentation] 体内時計におよぼすExcendin-4の影響2013
- Author(s)
  安藤　仁、牛島健太郎、藤村昭夫
- Organizer
  日本糖尿病学会
- Place of Presentation
  熊本ホテルキャッスル（熊本市）
- Data Source
  KAKENHI-PROJECT-24590666
[Presentation] 体内時計におよぼすエキセナチドの影響2012
- Author(s)
  安藤　仁、牛島健太郎、藤村昭夫
- Organizer
  日本時間生物学会
- Place of Presentation
  北海道大学学術交流会館（札幌市）
- Data Source
  KAKENHI-PROJECT-24590666
[Presentation] Activating transcription factor-4によるマウスセロトニントランスポーター発現リズムの制御2012
- Author(s)
  牛島健太郎
- Organizer
  薬学会第132年会
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22790166
[Presentation] 生体リズムと薬物の中枢神経系副作用2011
- Author(s)
  牛島健太郎
- Organizer
  第18回日本時間生物学会学術大会
- Place of Presentation
  名古屋大学(名古屋)
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-22790166
[Presentation] 体内時計システムを利用した薬物誘発性精神疾患予測法の構築2010
- Author(s)
  牛島健太郎
- Organizer
  第31回日本臨床薬理学会年会
- Place of Presentation
  京都国際会議場(京都)
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-22790166

1. ANDO Hitoshi (50382875)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. TAKAMURA Toshinari (00324111)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Satoshi Washino (50406162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 藤村昭夫 (90156901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 今井靖 (20359631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 土屋裕義 (80508755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 道具伸也 (60399186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田中泰圭 (50714466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 高田芙友子 (70412575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 岩尾卓朗 (30846374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 細畑圭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

USHIJIMA Kentaro 牛島 健太郎

牛島 健太郎 ウシジマ ケンタロウ

USHIJIMA Kentarou 牛島 健太郎

Research Projects

Research Products

Co-Researchers

Chronotherapeutic strategy for Parkinson's disease by intranasal administration of human iPS-derived brain pericytes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of chondrocyte deterioration and osteoarthritis caused by disturbance of biological clock systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prediction of drug disposition into brain in elders using clusters of daily variation in gene expression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a method to overcome treatment-resistant cancers by applying organ-specific regulation of gene expression by the biological clockPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of peripheral clock abnormalities caused by disturbance of central-peripheral tissue linkagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of a mechanism of lifestyle-related diseases focusing on the initiate-regulation of adipocyte differentiation by the clock systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Treatment of mTOR inhibtor-induced lung disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of pathophysiology and treatment strategies of peripheral clock disruption

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development for new targets of anti-depressants using biological clock-systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of pharmacological therapy targeting peripheral circadian clocks for treatment of type 2 diabetes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of a predict system of drug-induced depression by applying the circadian clock systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of insulin resistance based on clock genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 時間治療学－投薬のタイミングと効果－2013

Author(s)

USHIJIMA Kentaro 牛島健太郎

牛島健太郎ウシジマケンタロウ

USHIJIMA Kentarou 牛島健太郎