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aiba yoshihiro  相葉 佳洋

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AIBA Yoshihiro  相葉 佳洋

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Researcher Number 70450955
Affiliation (Current) 2025: 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 臨床研究センター, 研究員
Affiliation (based on the past Project Information) *help 2014 – 2023: 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 臨床研究センター, 研究員
2013: 独立行政法人国立病院機構(長崎医療センター臨床研究センター), その他部局等, 研究員
2013: 独立行政法人国立病院機構長崎医療センター臨床研究センター, 流動研究員
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related
Except Principal Investigator
Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords
Principal Investigator
原発性胆汁性胆管炎 / ゲノムワイド関連解析 / 疾患感受性遺伝子 / トランスクリプトーム解析 / カテプシン / GWAS / 原発性胆汁性肝硬変 / PRKCB / 肝臓学 / 肝不全 … More / 疾患関連遺伝子 / 重症化機構 / CTSZ / 肝臓 … More
Except Principal Investigator
疾患感受性遺伝子 / 治療標的 / 臨床ゲノム解析 / 疾患関連遺伝子 / ネガティブフィードバック機構 / IFNG / PTPN2 / 統合解析 / トランスクリプトーム / ゲノムワイド関連解析 / 原発性胆汁性胆管炎 / 疾患発症パスウェイ / 予後予測マーカー / 全ゲノム関連解析 / 肝臓学 / GWAS / 原発性胆汁性肝硬変 Less
  • Research Projects

    (7 results)
  • Research Products

    (100 results)
  • Co-Researchers

    (12 People)
  •  原発性胆汁性胆管炎の新たな病態解明と治療標的の同定を目指した臨床ゲノム解析

    • Principal Investigator
      中村 稔
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
  •  Analysis of POU2AF1 and its related molecules in the portal tract of primary biliary cholangitisPrincipal Investigator

    • Principal Investigator
      相葉 佳洋
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
  •  Analysis of PRKCB in primary biliary cholangitis based on integration analysis dataPrincipal Investigator

    • Principal Investigator
      AIBA YOSHIHIRO
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
  •  The role of cathepsin Z for liver failure-type progression in primary biliary cholangitisPrincipal Investigator

    • Principal Investigator
      AIBA YOSHIHIRO
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
  •  Analysis of molecular mechanisms involved in progression to jaundice and liver failure in primary biliary cholangitisPrincipal Investigator

    • Principal Investigator
      AIBA YOSHIHIRO
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
  •  Role of new disease-susceptibility gene in the development and pathogenesis of PBCPrincipal Investigator

    • Principal Investigator
      AIBA YOSHIHIRO
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
  •  Genome-wide associationstudy to detect disease-associated genes in Japanese patients with primary biliary cirrhosis

    • Principal Investigator
      NAKAMURA Minoru
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Department of Clinical Research, National Hospital Organization Nagasaki Medical Center

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book Other

  • [Book] 核膜康複合体タンパク質Gp210生体の科学細胞核-構造と機能2010

    • Author(s)
      中村稔、相葉佳洋
    • Publisher
      (財)金原一郎記念医学医療振興財団
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Journal Article] rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases2023

    • Author(s)
      Hitomi Yuki、Ueno Kazuko、Aiba Yoshihiro、Nishida Nao、Kawai Yosuke、Kawashima Minae、Khor Seik-Soon、Takada Sanami、Iwabuchi Chisato、Nagasaki Masao、Tokunaga Katsushi、Nakamura Minoru
    • Journal Title

      Human Genetics

      Volume: 143 Issue: 1 Pages: 19-33

    • DOI

      10.1007/s00439-023-02617-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K08065, KAKENHI-PROJECT-23K07366, KAKENHI-PROJECT-23K07471
  • [Journal Article] Novel HLA allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population2023

    • Author(s)
      Khor Seik-Soon、Ueno Kazuko、Nishida Nao、Kawashima Minae、Kawai Yosuke、Aiba Yoshihiro、Hitomi Yuki、Nagasaki Masao、Nakamura Minoru、Tokunaga Katsushi
    • Journal Title

      Frontiers in Immunology

      Volume: 14 Pages: 1151502-1151502

    • DOI

      10.3389/fimmu.2023.1151502

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08065, KAKENHI-PROJECT-23K07366, KAKENHI-PROJECT-23K07471
  • [Journal Article] rs9459874 and rs1012656 in CCR6/FGFR1OP confer susceptibility to primary biliary cholangitis2022

    • Author(s)
      Hitomi Yuki、Aiba Yoshihiro、Ueno Kazuko、Nishida Nao、Kawai Yosuke、Kawashima Minae、Yasunami Michio、Gervais Olivier、Ito Masahiro、Cordell Heather J.、Mells George F.、Nagasaki Masao、Tokunaga Katsushi、Tsuiji Makoto、Nakamura Minoru
    • Journal Title

      Journal of Autoimmunity

      Volume: 126 Pages: 102775-102775

    • DOI

      10.1016/j.jaut.2021.102775

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07334, KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-19K08413, KAKENHI-PROJECT-20K08370
  • [Journal Article] Regional heritability mapping identifies several novel loci (STAT4, 3 ULK4, and KCNH5) for primary biliary cholangitis in the Japanese 4 population2021

    • Author(s)
      Olivier Gervais, Kazuko Ueno, Yosuke Kawai, Yuki Hitomi, Yoshihiro Aiba, Mayumi Ueta, Minoru Nakamura, Katsushi Tokunaga & Masao Nagasaki
    • Journal Title

      European Journal of Human Genetics

      Volume: - Issue: 8 Pages: 1282-1291

    • DOI

      10.1038/s41431-021-00854-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08370, KAKENHI-PROJECT-19K08413
  • [Journal Article] Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome2020

    • Author(s)
      Jia Xiaoyuan、Yamamura Tomohiko、et al.
    • Journal Title

      Kidney International

      Volume: 98 Issue: 5 Pages: 1308-1322

    • DOI

      10.1016/j.kint.2020.05.029

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07799, KAKENHI-PROJECT-19K08726, KAKENHI-PROJECT-20K08370, KAKENHI-PROJECT-20K16892, KAKENHI-PROJECT-18KK0244, KAKENHI-PROJECT-20H03698
  • [Journal Article] Association of soluble T cell immunoglobulin domain and mucin-3 (sTIM-3) and mac-2 binding protein glycosylation isomer (M2BPGi) in patients with autoimmune hepatitis2020

    • Author(s)
      Kiyoshi Migita ,Minoru Nakamura,Yoshihiro Aiba,Hideko Kozuru,Seigo Abiru,Atsumasa Komori,Yuya Fujita,Junpei Temmoku,Tomoyuki Asano,Shuzo Sato,Makiko Furuya,Atsushi Naganuma,Kaname Yoshizawa,Masaaki Shimada,Keisuke Ario,Tomohiko Mannami,Hiroshi Kohno,Toshihiko Kaneyoshi,Takuya Komura,Hiromasa Ohira,Hiroshi Yatsuhashi
    • Journal Title

      PLoS One

      Volume: - Issue: 12 Pages: e0238540-e0238540

    • DOI

      10.1371/journal.pone.0238540

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Journal Article] NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional Variants.2018

    • Author(s)
      Hitomi Y, Nakatani K, Kojima K, Nishida N, Kawai Y, Kawashima M, Aiba Y, Nagasaki M, Nakamura M, Tokunaga K.
    • Journal Title

      Cell Mol Gastroenterol Hepatol

      Volume: 7 Issue: 3 Pages: 515-532

    • DOI

      10.1016/j.jcmgh.2018.11.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15924, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-17H04169, KAKENHI-PROJECT-17H04168, KAKENHI-PROJECT-17K09449
  • [Journal Article] Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis2018

    • Author(s)
      Aiba Yoshihiro、Harada Kenichi、Ito Masahiro、Suematsu Takashi、Aishima Shinichi、Hitomi Yuki、Nishida Nao、Kawashima Minae、Takatsuki Mitsuhisa、Eguchi Susumu、Shimoda Shinji、Nakamura Hitomi、Komori Atsumasa、Abiru Seigo、Nagaoka Shinya、Migita Kiyoshi、Yatsuhashi Hiroshi、Tokunaga Katsushi、Nakamura Minoru
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 11808-11808

    • DOI

      10.1038/s41598-018-30146-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09449, KAKENHI-PROJECT-17K15924, KAKENHI-PROJECT-17H04169
  • [Journal Article] Disease susceptibility genes shared by primary biliary cirrhosis and Crohn’s disease in the Japanese population2015

    • Author(s)
      Yoshihiro Aiba, Keiko Yamazaki, Nao Nishida, Minae Kawashima, Yuki Hitomi, Hitomi Nakamura, Atsumasa Komori, Yuta Fuyuno, Atsushi Takahashi, Takaaki Kawaguchi, Masakazu Takazoe, Yasuo Suzuki, Satoshi Motoya Toshiyuki Matsui Motohiro Esaki, Takayuki Matsumoto, Michiaki Kubo, Katsushi Tokunaga, Minoru Nakamura
    • Journal Title

      Journal of Human Genetics

      Volume: 印刷中 Issue: 9 Pages: 525-531

    • DOI

      10.1038/jhg.2015.59

    • NAID

      40020589506

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25860576, KAKENHI-PROJECT-15K06908, KAKENHI-PROJECT-15K19314, KAKENHI-PROJECT-15K19357, KAKENHI-PROJECT-26293180, KAKENHI-PROJECT-26293181
  • [Journal Article] Human primary biliary cirrhosis-susceptible allele of rs4979462 enhances TNFSF15 expression by binding NF-1.2015

    • Author(s)
      Hitomi Y, Kawashima M, Aiba Y, Nishida N, Matsuhashi M, Okazaki H, Nakamura M, Tokunaga K
    • Journal Title

      Human Genetics

      Volume: 印刷中 Issue: 7 Pages: 737-747

    • DOI

      10.1007/s00439-015-1556-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860576, KAKENHI-PROJECT-15K06908, KAKENHI-PROJECT-15K19314, KAKENHI-PROJECT-15K19357, KAKENHI-PROJECT-26293181
  • [Journal Article] Genetic polymorphisms of OCT-1 confer susceptibility to severe progression of primary biliary cirrhosis in Japanese patients.2014

    • Author(s)
      Ohishi Y, Nakamuta M, Ishikawa N, Saitoh O, Nakamura H, Aiba Y, Komori A, Migita K, Yatsuhashi H, Fukushima N, Kohjima M, Yoshimoto T, Fukuizumi K, Ishibashi M, Nishino T, Shirabe K, Taketomi A, Maehara Y, Ishibashi H, Nakamura M; PBC Study Group of NHOSLJ.
    • Journal Title

      J Gastroenterol.

      Volume: 49 Issue: 2 Pages: 332-342

    • DOI

      10.1007/s00535-013-0795-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591006, KAKENHI-PROJECT-26293181
  • [Journal Article] PBC Study Group of NHOSLJ, Nakamura M. Genetic polymorphisms of OCT-1 confer susceptibility to severe progression of primary biliary cirrhosis in Japanese patients2013

    • Author(s)
      Ohishi Y, Nakamuta M, Ishikawa N, Saitoh O, Nakamura H, Aiba Y, Komori K, Migita K, Yatsuhashi H, Fukushima N, Kohjima M, Yoshimoto T, Fukuizumi K, Ishibashi M, Nishino T, Shirabe K, Taketomi A, Maehara Y, Ishibashi H
    • Journal Title

      J Gastroenterol

      Volume: (Epub ahead of print)

    • Data Source
      KAKENHI-PROJECT-23591006
  • [Journal Article] Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis.2013

    • Author(s)
      Aiba Y, Harada K, Komori A, Ito M, Shimoda S, Nakamura H, Nagaoka S, Abiru S, Migita K, Ishibashi H, Nakanuma Y, Nishida N, Kawashima M, Tokunaga K, Yatsuhashi H, Nakamura M.
    • Journal Title

      Liver Int.

      Volume: 34 Issue: 5 Pages: 679-688

    • DOI

      10.1111/liv.12296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590393, KAKENHI-PROJECT-23591006, KAKENHI-PROJECT-25860576, KAKENHI-PROJECT-26293181, KAKENHI-PROJECT-26461012
  • [Journal Article] 特集:自己免疫性肝胆膵疾患の病態解明の進歩. 原発性胆汁性肝硬変患者におけるTL1AとDcR3の臨床学的意義2013

    • Author(s)
      相葉 佳洋, 小森 敦正, 長岡 進矢, 阿比留 正剛, 右田 清志, 伊東 正博, 石橋 大海, 八橋 弘, 中村 稔
    • Journal Title

      消化器と免疫

      Volume: 49 Pages: 15-17

    • Data Source
      KAKENHI-PROJECT-23591006
  • [Journal Article] 原発性胆汁性肝硬変(PBC)の疾患感受性遺伝子による病態の解明.2013

    • Author(s)
      中村 稔、西田奈央、川嶋実苗、相葉佳洋、小森敦正、八橋 弘、徳永勝士. 国立病院機構肝ネットワークPBC研究班、 厚生労働省難治性疾患克服研究事業・難治性の肝胆膵疾患に関する調査研究班.
    • Journal Title

      第20回浜名湖シンポジウム記録集 ゲノム情報の臨床応用

      Volume: なし Pages: 74-78

    • Data Source
      KAKENHI-PROJECT-23591006
  • [Journal Article] The Role of TL1A and DR3 in autoimmune and inflammatory diseases2013

    • Author(s)
      Aiba Y and Nakamura M
    • Journal Title

      Mediators of Inflammation

      Volume: (258164)

    • NAID

      120006986697

    • Data Source
      KAKENHI-PROJECT-23591006
  • [Journal Article] The role of TL1A and DR3 in autoimmune and inflammatory diseases.2013

    • Author(s)
      Aiba Y , Nakamura M.
    • Journal Title

      Mediators of Inflammation

      Volume: 未 Pages: 258164-258164

    • DOI

      10.1155/2013/258164

    • NAID

      120006986697

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591006, KAKENHI-PROJECT-25860576
  • [Journal Article] Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population.2012

    • Author(s)
      Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, et al
    • Journal Title

      Am J Hum Genet.

      Volume: Oct 5; 91(4): Pages: 721-728

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Journal Article] Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population2012

    • Author(s)
      Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka S, Kikuchi K, Ebinuma H, Yamashiki N, Tamura S, Sugawara Y, Mori A, Yagi S, Shirabe K, Taketomi A, Arai K, Monoe K, Ichikawa T, Taniai M, Miyake Y, Kumagi T, Abe M, Yoshizawa K, Joshita S, Shimoda S, Honda K, Takahashi H, Hirano K, Takeyama Y, Harada K, Migita K, Ito M, Yatsuhashi H, Fukushima N, Ota H, Komatsu T, Saoshiro T, Ishida J, Kouno H, Kouno H, Yagura M, Kobayashi M, Muro T, Masaki N, Hirata K, Watanabe Y, Nakamura Y, Shimada M, Hirashima N, Komeda T, Sugi K, Koga M, Ario K, Takesaki E, Maehara Y, Uemoto S, Kokudo N, Tsubouchi H, Mizokami M, Nakanuma Y, Tokunaga K, Ishibashi H
    • Journal Title

      Am J Hum Genet

      Volume: 91(4) Pages: 721-728

    • Data Source
      KAKENHI-PROJECT-23591006
  • [Journal Article] Serum amyloid A (SAA) induces pentraxin 3(PTX3) production in rheumatoid synoviocytes2012

    • Author(s)
      Satomura K, Torigoshi T, Koga T, Maeda Y, Izumi Y, Jiuchi Y, Miyashita T, Yamasaki S, Kawakami A, Aiba Y, Nakamura M, Komori A, Sato J, Ishibashi H, Motokawa S, Migita K
    • Journal Title

      Mod Rheumatol

      Volume: (Epub ahead of print)

    • NAID

      10031167663

    • Data Source
      KAKENHI-PROJECT-23591006
  • [Journal Article] A polymorphism in the integrin alfa V subunit gene affects the progression of primary biliary cirrhosis in Japanese patients.2011

    • Author(s)
      Inamine T, Nakamura M, Kawauchi A, Shirakawa Y, Hashiguchi H, Aiba Y, Taketomi A, Shirabe K, Nakamuta M, Hayashi S, Saoshiro T, Komori A, Yatsuhashi H, Kondo S, Omagari K, etal
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 676-686

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Journal Article] Genetic polymorphisms of CTLA4 and SLC4A2 are differently associated with the pathogenesis of primary biliary cirrhosis in Japanese patients.2011

    • Author(s)
      Aiba Y, Nakamura M, Joshita S, Inamime T, Komori A, Yoshizawa K, Umemura T, Horie H, Migita K, Yatsuhashi H, Nakamuta M, Fukushima N, Saoshiro T, Hayashi S, Kouno et al
    • Journal Title

      J Gastroenterol 2011

      Volume: 46 Pages: 1203-1212

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] 国際メタ GWAS によって同定された原発性胆汁性胆管炎(PBC)感受性遺伝子領域 CD28 に由来する発症機序の解明.2023

    • Author(s)
      人見祐基, 相葉佳洋 中村 稔相葉佳洋, 西田奈央, 中村 稔.
    • Organizer
      第59回日本肝臓学会総会.
    • Data Source
      KAKENHI-PROJECT-23K07471
  • [Presentation] パネルディスカッション2; 自己免疫性肝胆疾患診療の未来予想図(現状と課題),  原発性胆汁性胆管炎の新たな病態解明と治療標的の同定を目指した臨床ゲノム解析.2023

    • Author(s)
      中村 稔、植野和子、相葉佳洋
    • Organizer
      第59回日本肝臓学会総会.  奈良 2023.6.16
    • Data Source
      KAKENHI-PROJECT-23K07366
  • [Presentation] Novel HLA allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population.2023

    • Author(s)
      Knor SS, 植野和子, 西田奈央, 川嶋実苗, 河合洋介, 相葉佳洋, 人見祐基, 長﨑正朗, 中村稔, 徳永勝士
    • Organizer
      第6回関東HLA研究会
    • Data Source
      KAKENHI-PROJECT-23K07471
  • [Presentation] 原発性胆汁性胆管炎の新たな病態解明と治療標的の同定を目指した臨床ゲノム解析2023

    • Author(s)
      中村 稔, 植野和子, 相葉佳洋.
    • Organizer
      第59回日本肝臓学会総会.
    • Data Source
      KAKENHI-PROJECT-23K07471
  • [Presentation] 自己免疫疾患感受性遺伝子に起因する発症機序の解明におけるCRISPR/Cas9の活用2023

    • Author(s)
      人見祐基, 植野和子, 相葉佳洋, 西田奈央, 川嶋実苗, Khor SS, 長崎正朗, 徳永勝士, 中村稔
    • Organizer
      日本ゲノム編集学会
    • Data Source
      KAKENHI-PROJECT-23K07471
  • [Presentation] 抗原提示補助シグナル分子の遺伝的バリアントに起因する自己免疫疾患感受性の分子機序の解明2023

    • Author(s)
      人見祐基, 植野和子, 相葉佳洋, 西田奈央, 河合洋介, 川嶋実苗, Knor SS, 長﨑正朗, 徳永勝士, 中村稔
    • Organizer
      第31回日本組織適合性学会
    • Data Source
      KAKENHI-PROJECT-23K07471
  • [Presentation] ワークショップ2; 肝胆膵免疫疾患の最新の知見,  原発性胆汁性胆管炎のトランスクリプトームデータを用いた治療標的遺伝子の探索2023

    • Author(s)
      相葉佳洋、植野和子, 中村 稔
    • Organizer
      第60回日本消化器免疫学会総会. 東京 2023.10.6
    • Data Source
      KAKENHI-PROJECT-23K07366
  • [Presentation] 原発性胆汁性胆管炎のゲノムワイド関連解析による病態の解明2023

    • Author(s)
      相葉佳洋, 植野和子, 人見祐基, 小森敦正, 中村 稔.
    • Organizer
      第121回日本消化器病学会九州支部例会.
    • Data Source
      KAKENHI-PROJECT-23K07471
  • [Presentation] Identification of a gene expression regulatory variant in autoimmune diseasessusceptibility locus CD582023

    • Author(s)
      Yuki Hitomi, Kazuko Ueno, Yoshihiro Aiba, Nao Nishida, Yosuke Kawai, Minae Kawashima , Seik-Soon Khor, Sanami Takada, Chisato Iwabuchi, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
    • Organizer
      Human Genetics Asia 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07471
  • [Presentation] 原発性胆汁性胆管炎のトランスクリプトームデータを用いた治療標的遺伝子の探索2023

    • Author(s)
      相葉佳洋, 植野和子, 人見祐基, 伊東正博, 小森敦正, 中村 稔.
    • Organizer
      第60回日本消化器免疫学会総会.
    • Data Source
      KAKENHI-PROJECT-23K07471
  • [Presentation] 国際メタ GWAS によって同定された原発性胆汁性胆管炎(PBC)感受性遺伝子領域 CCR6/FGFR1OP に由来する発症機序の解明2022

    • Author(s)
      人見祐基, 相葉佳洋, 中村 稔
    • Organizer
      第58回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] PBC-GWAS の国際メタ解析とトランスクリプトームの統合解析による新規治療標的の同定2022

    • Author(s)
      植野和子, 中村 稔, 相葉佳洋
    • Organizer
      第58回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] 様々な免疫形質と関連するCD28領域におけるスプライシング制御バリアントの同定 Identification of splicing regulatory variants in multiple immunological traits-susceptibility locus CD28"2022

    • Author(s)
      人見祐基, 相葉 佳洋, 植野 和子, 西田 奈央, 河合 洋介, 川嶋 実苗, 築地 信, 岩渕 千里, 高田 紗奈美, 三宅 紀子, 長崎 正朗, 徳永 勝士, 中村 稔
    • Organizer
      日本人類遺伝学会第67回大会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] 原発性胆汁性胆管炎の肝組織におけるPOU2AF1とその関連遺伝子の解析2022

    • Author(s)
      相葉佳洋, 伊東正博, 植野和子, 人見祐基, 小森敦正, 阿比留正剛, 長岡進矢, 八橋 弘, 長崎正朗, 徳永勝士, 中村 稔
    • Organizer
      第50回日本臨床免疫学会総会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] 原発性胆汁性胆管炎の疾患感受性遺伝子 POU2AF1 が制御する遺伝子の検討2022

    • Author(s)
      相葉佳洋, 植野和子, 人見祐基, 西田奈央, 小森敦正, 阿比留正剛, 長岡進矢, 八橋 弘, 中村 稔
    • Organizer
      第58回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] Transcriptome and GWAS identified IL4, IL5, and GATA2 as critical upstream regulators in blood and IFNG in liver for eosinophilia in primary biliary cholangitis2022

    • Author(s)
      植野和子, 人見祐基, 相葉佳洋, Gervais Olivier, 河合洋介, Khor Seik Soon, 川嶋実苗, 西田奈央, 小島要, 長崎正朗, 徳永勝士, 中村稔
    • Organizer
      2022 American Society of Human Genetics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] Identification of seven primary functional variants in primary biliary cholangitis susceptibility loci in the Japanese population2021

    • Author(s)
      Yuki Hitomi, Yoshihiro Aiba, Yosuke Kawai, Kaname Kojima, Kazuko Ueno, Nao Nishida, Minae Kawashima, Olivier Gervais, Seik-Soon Khor, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, Makoto Tsuiji
    • Organizer
      ASHI2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] 肝組織アレイデータに基づいた日本人原発性胆汁性胆管炎の疾患感受性遺伝子 POU2AF1 とその関連遺伝子の解析.2021

    • Author(s)
      相葉佳洋、植野和子、人見祐基、小森敦正、橋元悟、戸次鎮宗、阿比留正剛、長岡進矢、八橋弘、中村稔
    • Organizer
      第58回日本消化器免疫学会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] Identification of the primary functional variants in primary biliary cholangitis susceptibility gene CCR6/FGFR1OP2021

    • Author(s)
      Yuki Hitomi, Yoshihiro Aiba, Makoto Tsuiji,Minoru Nakamura
    • Organizer
      第50回日本免疫学会総会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] Transcriptome and GWAS identified rs2238678 as a critical SNP for eosinophilia in primary biliary cholangitis2021

    • Author(s)
      Kazuko Ueno,Yosuke Kawai,Yuki Hitomi,Yoshihiro Aiba,Mayumi Ueta,Minoru Nakamura,Katsushi Tokunaga,Masao Nagasaki
    • Organizer
      ASHG2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] 原発性胆汁性胆管炎(PBC)感受性遺伝子CCR6/FGFR1OPにおけるprimary functional variantsの同定2021

    • Author(s)
      人見祐基、相葉佳洋、西田奈央、河合洋介、川嶋実苗、安波道朗、Olivier Gervais、長﨑正朗、徳永勝士、築地信、中村稔
    • Organizer
      第66回人類遺伝学会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] rs1944919 on human chromosome 11q23.1 and its effector genes COLCA1 and COLCA2 confer susceptibility to primary biliary cholangitis2021

    • Author(s)
      Yuki Hitomi, Yoshihiro Aiba, Yosuke Kawai, Kaname Kojima, Kazuko Ueno, Nao Nishida, Minae Kawashima, Olivier Gervais, Seik-Soon Khor, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, Makoto Tsuiji
    • Organizer
      2021 American Society for Histocompatibility and Immunogenetics Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] COLCA1 and COLCA2, the effector genes driven by rs1944919 in primary biliary cholangitis (PBC) susceptibility locus chromosome 11q23.1 in the Japanese population2021

    • Author(s)
      Yuki Hitomi, Yoshihiro Aiba, Yosuke Kawai, Kaname Kojima, Kazuko Ueno, Nao Nishida, Minae Kawashima, Olivier Gervais, Seik-Soon Khor, Masao Nagasaki, Katsushi Tokunaga, Makoto Tsuiji, Minoru Nakamura
    • Organizer
      APASL STC 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] Applying the regional heritability mapping method to primary biliary cholangitis in the Japanese population2021

    • Author(s)
      Olivier Gervais, Yoshihiro Aiba, Kazuko Ueno, Yosuke Kawai, Nao Nishida, Minae Kawashima, Olivier Gervais, Masao Nagasaki, Katsushi Tokunaga, Makoto Tsuiji, Minoru Nakamura
    • Organizer
      ASHG2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] 原発性胆汁性胆管炎における疾患感受性遺伝子 POU2AF1 とその関連遺伝子の解析.2021

    • Author(s)
      相葉佳洋、植野和子、 人見祐基、 西田奈央、 下田慎治、 小森敦正、 橋元 悟、戸次鎮宗、 阿比留正剛、 長岡進、八橋 弘、 中村 稔.
    • Organizer
      第57回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] 原発性胆汁性胆管炎に関与する遺伝子の共発現ネットワーク解析2020

    • Author(s)
      相葉佳洋, 植野和子, 人見祐基, 小森敦正, 橋元 悟, 戸次鎮宗, 阿比留正剛, 長岡進矢, 八橋 弘, 中村 稔.
    • Organizer
      第56回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] 原発性胆汁性胆管炎(PBC)感受性遺伝子領域Chromosome 11q23.1におけるeffector遺伝子COLCA1およびCOLCA2の同定 COLCA1/COLCA2, the effector genes in primary biliary cholangitis susceptibility locus chromosome 11q23.12020

    • Author(s)
      人見祐基, 相葉佳洋, 河合洋介, 児島要, 植野和子, 西田奈央, 川嶋実苗, Olivier Gervais, Seik-Soon Khor,長﨑正朗, 徳永勝士, 中村稔, 築地信
    • Organizer
      第65回日本人類遺伝学会
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] The analysis of POU2AF1 and its related molecules in the pathogenesis of primary biliary cholangitis by using GWAS and transcriptome datasets2020

    • Author(s)
      Yoshihiro Aiba, Kazuko Ueno, Yuki Hitomi, Olivier Gervais, Yosuke Kawai, Minae Kawashima, Nao Nishida, Kaname Kojima, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
    • Organizer
      第70回アメリカ人類遺伝学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] Integrated GWAS and mRNA microarray analysis identified IFNG and CD40L as the central upstream regulators in primary biliary cholangitis2020

    • Author(s)
      Kazuko Ueno, Yoshihiro Aiba, Yuki Hitomi, Shinji Shimoda, Hitomi Nakamura, Olivier Gervai, Yosuke Kawai, Seik-Soon Khor, Minae Nao Nishida, Kaname Kojima, Kawashima, Nao Nishida,Atsumasa Komori, Hiroshi Yatsuhashi, Atsushi Tanaka, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, and PBC-GWAS consortium in Japan
    • Organizer
      ヨーロッパ肝臓学会総会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08370
  • [Presentation] 発性胆汁性胆管炎に関与する遺伝子の共発現ネットワーク解析.2020

    • Author(s)
      相葉佳洋、植野和子、人見祐基、小森敦正、橋元悟、戸次鎮宗、阿比留正剛、長岡進矢、黒木保、八橋弘、中村稔
    • Organizer
      第56回日本肝臓学会総会.
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] Integrated analysis of GWAS and mRNA expression array identified IFNG and CD40L as the most significant upstream-regulators in primary biliary cholangitis.2019

    • Author(s)
      Ueno K, Aiba Y, Hitomi Y, Shimoda S, O Gervais, Kawai Y, Kawashima M, Nishida N, Kojima K, Nagasaki M, Tokunaga K, Nakamura M.
    • Organizer
      The 69th Annual Meeting of The American Society of Human Genetics (ASHG 2019).
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] 原発性胆汁性胆管炎(PBC)感受性遺伝子領域に起因する発症機序の解明におけるゲノム編集技術の応用.2019

    • Author(s)
      人見祐基, 河合洋介, 植野和子, 西田奈央, 川嶋実苗, 相葉佳洋, Olivier Gervais, Seik-Soon Khor, 築地 信, 長崎正朗, 中村 稔, 徳永勝士.
    • Organizer
      日本人類遺伝学会第64回大会.
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] Integrated analysis of GWAS and mRNA expression array identified IFNG and CD40L as the most significant upstream-regulators in primary biliary cholangitis.2019

    • Author(s)
      Ueno K, Aiba Y, Hitomi Y, Shimoda S, O Gervais, Kawai Y, Kawashima M, Nishida N, Kojima K, Nagasaki M, Tokunaga K, Nakamura M.
    • Organizer
      The 69th Annual Meeting of The American Society of Human Genetics.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] 原発性胆汁性胆管炎の肝組織網羅的遺伝子発現データを用いた疾患感受性遺伝子ならびに疾患関連pathwayの解析.2019

    • Author(s)
      相葉佳洋、西田奈央, 人見祐基, 小森敦正, 八橋 弘, 中村 稔.
    • Organizer
      第55回日本肝臓学会総会.
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] Integrated analysis of GWAS and mRNA microarray identified IFNG and CD40L as the central upstream-regulators in primary biliary cholangitis2019

    • Author(s)
      Ueno K, Aiba Y, Hitomi Y, Shimoda S, O Gervais, Kawai Y, Kawashima M, Nishida N, Kojima K, Nagasaki M, Tokunaga K, Nakamura M and PBC-GWAS Consortium in Japan.
    • Organizer
      The International Liver Congress 2019 (ILC2019).
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] POGLUT1, The Effector Gene Driven by rs2293370 in Primary Biliary Cholangitis (PBC) Susceptibility Locus Chromosome 3q13.33 in The Japanese Population.2019

    • Author(s)
      Hitomi Y, Ueno K, Kawai Y, Nishida N, Kojima K, Kawashima M, Aiba Y, Shimoda S, Tanaka A, Nagasaki M, Tokunaga K, Nakamura M, PBC-GWAS Consortium in Japan.
    • Organizer
      APASL STC Tokyo 2019.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] Pathway-Analysis Using Datasets of GWAS and mRNA Expression Array Identified IFNG as the Most Significant Upstream-Regulator in Primary Biliary Cholangitis.2019

    • Author(s)
      Ueno K, Aiba Y, Hitomi Y, Shimoda S, Tanaka A, Olivier Gervais, Kawai Y, Kawashima M, Nishida N, Kojima K, Nagasaki M, Tokunaga K, Nakamura M, PBC-GWAS consortium in Japan.
    • Organizer
      APASL STC Tokyo 2019.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] Role of PRKCB in the development of primary biliary cholangitis2019

    • Author(s)
      Aiba Y, Hitomi Y, Ueno K, Nakamura M.
    • Organizer
      The 48th Annual Meeting of the Japanese Society of Immunology
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] The role of PRKCB in the development of primary biliary cholangitis2019

    • Author(s)
      Aiba Y, Ueno K, Hitomi Y, Kawashima M, Nishida N, Kawai Y, Komori A, Yatsuhashi H, Nagasaki M, Tokunaga K, Nakamura M and PBC-GWAS consortium in Japan
    • Organizer
      AASLD THE LIVER MEETING 2019.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] Integrated analysis of GWAS and mRNA microarray revealed IFN-g as the most significant signature in the disease-pathways of primary biliary cholangitis in the Japanese population2018

    • Author(s)
      Yoshihiro Aiba, Kazuko Ueno, Shinji Shimoda, Yuki Hitomi, Minae Kawashima, Nao Nishida, Yosuke Kawai, Atsumasa Komori, Hiroshi Yatsuhashi, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, PBC-GWAS consortium in Japan et al.
    • Organizer
      AASLD 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] Cathepsin Z variants are associated with progression to end-stage hepatic failure in Japanese patients with primary biliary cholangitis2017

    • Author(s)
      Nao Nishida, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Hitomi Nakamura, Noriyo Yamashiki, Tomohiro Tanaka, Sumito Tamura, Akira Mori, Shintaro Yagi, Yuji Soejima, Ken Shirabe, Atsushi Tanaka, Kenichi Harada, Shinji Shimoda Atsumasa Komori, Katsushi Tokunaga, Minoru Nakamura et al.
    • Organizer
      ヨーロッパ肝臓学会総会
    • Place of Presentation
      アムステルダム
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19357
  • [Presentation] 原発性胆汁性胆管炎の重症化にカテプシンの果たす役割の検討2017

    • Author(s)
      相葉佳洋, 原田憲一, 相島慎一, 伊東正博, 人見祐基, 西田奈央, 小森敦正, 八橋 弘, 中村 稔
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] 日本人原発性胆汁性胆管炎における黄疸型進行関連遺伝子の同定と発現・機能解析2017

    • Author(s)
      相葉佳洋, 西田奈央, 人見祐基, 川嶋実苗, 徳永勝士, 中村 稔
    • Organizer
      第45回日本臨床免疫学会総会.
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] Increased expression and altered localization of cathepsin Z is associated with progression to jaundice-stage in primary biliary cholangitis2017

    • Author(s)
      Aiba Y, Harada K, Ito M, Aishima S, Hitomi Y, Nishida N, Kawashima M, Uemoto S, Kokudo N, Takatsuki M, Eguchi S, Shimoda S, Nakamura H, Komori A, Abiru S, Nagaoka S, Yatsuhashi H, Tokunaga K, Nakamura M
    • Organizer
      AASLD The Liver Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] Increased expression and altered localization of cathepsin Z is associated with progression to end-stage hepatic failure in primary biliary cholangitis2017

    • Author(s)
      Yoshihiro Aiba, Kenichi Harada, Masahiro Ito, Shinichi Aishima, Atsumasa Komori, Hiroshi Yatsuhashi, Minoru Nakamura and Headquarters of PBC Research in the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ)
    • Organizer
      EASL 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09449
  • [Presentation] 日本人原発性胆汁性肝硬変における黄疸・肝不全型進行関連遺伝子の同定2016

    • Author(s)
      相葉佳洋、西田奈央、中村稔
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ幕張
    • Data Source
      KAKENHI-PROJECT-15K19357
  • [Presentation] 原発性胆汁性肝硬変におけるTL1Aの役割2015

    • Author(s)
      相葉佳洋、小森敦正、中村 稔
    • Organizer
      第41回日本肝臓学会西部会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-15K19357
  • [Presentation] 日本人原発性胆汁性肝硬変の新規疾患感受性遺伝子PRKCB, ETS1 の同定2015

    • Author(s)
      相葉佳洋、川嶋美苗、 西田奈央、 人見祐基、小森敦正、 茶山一彰、安波道郎、徳永勝士、 中村 稔
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本ホテル日航
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-15K19357
  • [Presentation] Shared Disease-Susceptibility genes between primary biliary cirrhosis and Crohn's disease in the Japanese population2015

    • Author(s)
      Yoshihiro Aiba, Keiko Yamazaki,Nao Nishida, Minae Kawashima, Yuki Hitomi, Atsumasa Komori, Michiaki Kubo, Katsushi Tokunaga, Minoru Nakamura
    • Organizer
      ヨーロッパ肝臓学会総会
    • Place of Presentation
      ウィーン
    • Year and Date
      2015-04-22
    • Data Source
      KAKENHI-PROJECT-15K19357
  • [Presentation] 日本人原発性胆汁性肝硬変患者におけるTLIAの役割2013

    • Author(s)
      相葉佳洋, 原田憲一, 小森敦正, 伊東正博, 阿比留正剛, 長岡進矢, 石橋大海, 中沼安二, 八橋弘, 中村稔
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-06
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] WHO MAY HAVE TREATMENT BENEFITS WITH FIBRATES IN PRIMARY BILIARY CIRRHOSIS : A SINGLE CENTER RETROSPECTIVE OBSERVATIONAL COHORT ANALYSIS2013

    • Author(s)
      A. Komori, M. Nakamura, Y. Aiba, Y. Kugiyama-Yasunaga, S. Bekki, R. Sasaki, S. Hashimoto, M. Ootani, S.-K. Bae, A. Saeki, S. Nagaoka, S. Abiru, K. Yamasaki, H. Ishibashi, H. Yatsuhashi
    • Organizer
      48th annual meeting of the European Association for the Study of the Liver
    • Place of Presentation
      Amsterdam, The Netherlands
    • Year and Date
      2013-04-26
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] Systemic and local expression of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis.2013

    • Author(s)
      Yoshihiro Aiba, Kenichi Harada, Atsumasa Komori, Masahiro Ito, Shinji Shimoda, Shinya Nagaoka, Seigo Abiru, Kiyoshi Migita, Hiromi Ishibashi, Yasuni Nakanuma, Nao Nishida, Minae Kawashima, Katsushi Tokunaga, Hiroshi Yatsuhashi, Minoru Nakamura.
    • Organizer
      AASLD THE LIVER MEETING 2013
    • Place of Presentation
      Washington, DC, USA
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] 原発性胆汁性肝硬変の肝局所におけるTL1A産生機構の解明2013

    • Author(s)
      相葉佳洋、原田憲一、小森敦正、阿比留正剛、長岡進矢、右田清志、伊東正博、中沼安二、八橋 弘、中村 稔
    • Organizer
      第50回日本消化器免疫学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] ヒト胆管上皮細胞におけるTL1A産生機構の解析2013

    • Author(s)
      相葉佳洋、小森敦正、伊東正博、右田清志、八橋 弘、中村 稔
    • Organizer
      第41回日本臨床免疫学会
    • Place of Presentation
      下関
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] 日本人原発性胆汁性肝硬変におけるTL1Aの役割2013

    • Author(s)
      相葉佳洋、原田憲一、小森敦正、阿比留正剛、長岡進矢、右田清志、石橋大海、中沼安二、八橋 弘、中村 稔
    • Organizer
      第49回日本肝蔵学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] ヒト胆管上皮細胞における TL1A 産生機構の解析2013

    • Author(s)
      相葉佳洋、小森敦正, 伊東正博, 右田清志, 八橋 弘, 中村 稔.
    • Organizer
      第41回日本臨床免疫学会総会
    • Place of Presentation
      海峡メッセ下関
    • Data Source
      KAKENHI-PROJECT-25860576
  • [Presentation] The mechanism of TL1A production in human biliary epithelial cells.2013

    • Author(s)
      Yoshihiro Aiba, Atsumasa Komori, Masahiro Ito, Kiyoshi Migita, Hiroshi Yatsuhashi, Minoru Nakamura.
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張、千葉
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] 日本人原発性胆汁性肝硬変の病態形成に関与するHLA-A,-B,-DP,-DR遺伝子多型とCTLA-4, SLC4A2, IL12A, IRF5遺伝子多型の検討2012

    • Author(s)
      相葉佳洋, 安波道郎, 小森敦正, 右田清志, 八橋弘, 中牟田誠, 福嶋伸良, 太田肇, 石田仁也, 平田啓一, 渡部幸夫, 小松達司, 矢倉道泰, 高野弘嗣, 室豊吉, 島田昌明, 米田俊貴, 山下晴弘, 竹崎英一, 古賀満明, 小林正和, 杉和洋, 正木尚彦, 古澤要, 蒔田富士雄, 高木均, 西村英夫, 石橋大海, 中村稔
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] 日本人原発性胆汁性肝硬変の病態形成に関与するHLA-A,-B,-DP,-DR 遺伝子多型とCTLA-4, SLC4A2, IL12A, IRF5 遺伝子多型の検討2012

    • Author(s)
      相葉 佳洋, 安波道郎, 小森敦正, 右田清志, 八橋 弘, et al
    • Organizer
      第48回 日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] 日本人原発性胆汁性肝硬変におけるIL12A,IL12RB2,IRF5,染色体17q12-21領域の遺伝子多型の解析2011

    • Author(s)
      相葉佳洋、小森敦正、右田清志、八橋 弘、石橋大海、中村 稔
    • Organizer
      第48回日本消化器免疫学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] 日本人原発性胆汁性肝硬変における免疫関連分子の遺伝子多型の解析2011

    • Author(s)
      相葉佳洋,稲嶺達夫,城下智,小森敦正,右田清志,八橋弘,中牟田誠,福嶋伸良,竿代丈夫,林茂樹,渡部幸夫,矢倉道泰,高野弘嗣,室豊吉,太田肇,島田昌明,米田俊貴,山下晴弘,竹崎英一,古賀満明,小松達司,小林正和,杉和洋,高橋正彦,正木尚彦,吉澤要,塚元和弘,石橋大海,中村稔
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] 日本人原発性胆汁性肝硬変におけるCTLA4,IL12A,IL12RB2,IRF5,染色体17q12-21領域の遺伝子多型の解析2011

    • Author(s)
      相葉佳洋、城下 智、吉澤 要、梅村武司、小森敦正、右田清志、八橋 弘、石橋大海、中村 稔
    • Organizer
      第39回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] 日本人原発性胆汁性肝硬変のOCT-1遺伝子の多型解析2011

    • Author(s)
      大石裕樹、石川奈緒子、石橋 誠、福嶋伸良、中牟田誠、相葉佳洋、小森敦正、石橋大海、中村 稔
    • Organizer
      第20回西日本臨床胆汁酸研究会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23591006
  • [Presentation] 原発性胆汁性肝硬変の肝局所におけるTL1A産生機構の解明

    • Author(s)
      相葉佳洋、原田憲一, 小森敦正, 阿比留正剛, 長岡進矢, 右田清志, 伊東正博, 中沼安二, 八橋 弘, 中村 稔.
    • Organizer
      第50回日本消化器免疫学会総会
    • Place of Presentation
      ホテルグランドヒル市ヶ谷
    • Data Source
      KAKENHI-PROJECT-25860576
  • [Presentation] 日本人の原発性胆汁性肝硬変とクローン病における疾患感受性遺伝子の共通性と異質性

    • Author(s)
      相葉佳洋、山﨑慶子、川嶋実苗、西田奈央、小森敦正, 4, 久保充明、徳永勝士、中村稔
    • Organizer
      第59回日本人類遺伝学会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2015-11-19 – 2015-11-22
    • Data Source
      KAKENHI-PROJECT-25860576
  • [Presentation] Systemic and local expression of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis

    • Author(s)
      Yoshihiro Aiba, Kenichi Harada, Atsumasa Komori, Masahiro Ito, Shinji Shimoda, Shinya Nagaoka, Seigo Abiru, Kiyoshi Migita, Hiromi Ishibashi, Yasuni Nakanuma, Nao Nishida, Minae Kawashima, Katsushi Tokunaga, Hiroshi Yatsuhashi, Minoru Nakamura
    • Organizer
      The American Association for the Study of Liver Diseases (AASLD) the Liver Meeting Washington
    • Place of Presentation
      Washington Convention Center
    • Data Source
      KAKENHI-PROJECT-25860576
  • [Presentation] 日本人原発性胆汁性肝硬変とクローン病に共通する疾患感受性遺伝子の検討

    • Author(s)
      相葉佳洋、山﨑慶子、川嶋実苗、西田奈央、小森敦正, 久保充明、徳永勝士、中村稔
    • Organizer
      第51回日本消化器免疫学会
    • Place of Presentation
      京都大学医学部 芝蘭会館(京都府、京都市
    • Year and Date
      2014-07-10 – 2014-07-11
    • Data Source
      KAKENHI-PROJECT-25860576
  • [Presentation] SHARED DISEASE-SUSCEPTIBILITY GENES BETWEEN PRIMARY BILIARY CIRRHOSIS AND CROHN’S DISEASE IN THE JAPANESE POPULATION

    • Author(s)
      Yoshihiro Aiba, Keiko Yamazaki, Nao Nishida, Minae Kawashima, Yuki Hitomi, Atsumasa Komori, Michiaki Kubo, Katsushi Tokunaga, Minoru Nakamura
    • Organizer
      The 50th International Liver Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-04-22 – 2015-04-26
    • Data Source
      KAKENHI-PROJECT-25860576
  • [Presentation] 日本人原発性胆汁性肝硬変患者におけるTLIAの役割

    • Author(s)
      相葉佳洋、原田憲一, 小森敦正, 伊東正博, 阿比留正剛, 長岡進矢, 石橋大海, 中沼安二, 八橋 弘, 中村 稔.
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル
    • Data Source
      KAKENHI-PROJECT-25860576
  • [Presentation] The mechanism of TL1A production in human biliary epithelial cells

    • Author(s)
      Yoshihiro Aiba, Komori A, Ito M, Migita K, Yatsuhashi H, Nakamura M.
    • Organizer
      Annual Meeting of The Japanese Society for Immunology, 2013
    • Place of Presentation
      幕張メッセ
    • Data Source
      KAKENHI-PROJECT-25860576
  • [Presentation] Identification of primary biliary cirrhosis - susceptible variant in human TNFSF15 locus and its functional analysis

    • Author(s)
      Yuki Hitomi, Minae Kawashima, Yoshihiro Aiba, Nao Nishida, Minoru Nakamura, Katsushi Tokunaga
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府、京都市
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-25860576
  • []

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  • 1.  NAKAMURA Minoru (40217906)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 71 results
  • 2.  伊東 正博 (30184691)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 23 results
  • 3.  ISHIBASHI Hiromi (80127969)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 14 results
  • 4.  MIGITA Kiyoshi (60264214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 16 results
  • 5.  KOMORI Atsumasa (50234901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 21 results
  • 6.  高槻 光寿 (80380939)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  植野 和子 (00794512)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  人見 祐基 (10525819)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  西田 奈央 (50456109)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  長崎 正朗 (90396862)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  築地 信
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  原田 憲一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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