NAKADA TSUTOMU 中田勉

… Alternative Names

NAKADA Tsutomu 中田勉

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Researcher Number	70452141
Other IDs
Affiliation (Current)	2025: 信州大学, 学術研究院総合人間科学系, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 信州大学, 学術研究院総合人間科学系, 准教授 2014 – 2017: 信州大学, 学術研究院医学系, 講師 2012 – 2013: 信州大学, 医学部, 講師 2007 – 2011: Shinshu University, 医学部, 助教 2008: 信州大, 医学部, 助教
Review Section/Research Field	Principal Investigator General physiology / Basic Section 48020:Physiology-related Except Principal Investigator General pharmacology / Basic Section 48020:Physiology-related / Basic Section 55050:Anesthesiology-related / Orthopaedic surgery
Keywords	Principal Investigator L型カルシウムチャネル / ジャンクトフィリン / リアノジン受容体 / 興奮収縮連関 / 結合膜構造 / 骨格筋 / 心筋 / T管 / カルシウムチャネル / 循環器 … More / ジャンクトフィリン2 / カルシウム / 心不全 / Ｌ型カルシウムチャネル / カプロン / 循環器・高血圧 / 生理学 … More Except Principal Investigator L型カルシウムチャネル / 発達生理学 / 細胞内情報伝達機構 / AT１受容体 / アンジオテンシンII / 発達薬理学 / バイアス信号 / G蛋白質 / 心筋細胞 / I型アンジオテンシンII受容体 / レニン・アンジオテンシン系 / ナトリウムチャネル / 局所麻酔薬 / 痛み / L型Ca2+チャネル / 筋委縮 / 除神経 / 骨格筋 / 加齢 / サルコペニア / SK&F96365 / 早期後脱分極 / 心室性不整脈 / TRPCチャネル / 心不全 / 血液 / 心血管 / 不活性化 / Ca_v1.2 / アロステリックモデル / Timothy症候群 / 膜電位依存性不活性化 / ジヒドロピリジン / Ca_V<1. 2> L型カルシウムチャネル Less

Analyses of the molecular mechanism underlying and the functional significance of developmental changes in intracellular signal transduction systems coupled to cardiac AT1 receptors.
- Principal Investigator
  
  山田充彦
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Shinshu University
組織特異的ノックアウト手法を用いた骨格筋ジャンクトフィリンのサブタイプ別機能解析Principal Investigator
- Principal Investigator
  
  中田勉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Shinshu University
Role of junctophilin degradation in the formation of heart failurePrincipal Investigator
- Principal Investigator
  
  Nakada Tsutomu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Shinshu University
Development of novel Nav1.7 antagonist by using molecular pharmacological methods
- Principal Investigator
  
  Ishida Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Shinshu University
Role of junctophilins on excitation-contraction coupling of skeletal musclesPrincipal Investigator
- Principal Investigator
  
  Nakada Tsutomu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University
Changes in expression of L-type calcium channel subunits in skeletal muscle with aging.
- Principal Investigator
  
  KATO Hiroyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Localization and function of L-type calcium channels in skeletal muscle is regulated by junctophilins.Principal Investigator
- Principal Investigator
  
  NAKADA Tsutomu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University
Junctional membrane-targeting mechanism of cardiac L-type calcium channelPrincipal Investigator
- Principal Investigator
  
  NAKADA Tsutomu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University
Quantitative analysis of the open-state affinity of L-type calcium channel blockers and modeling of their inhibitory actions
- Principal Investigator
  
  YAMADA Mitsuhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Shinshu University
Roles of TRPC channel activation in the induction of ventricular tachycardias
- Principal Investigator
  
  HIROSE Masamichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Iwate Medical University
  Shinshu University
Analysis of molecules related to structure and function of T-tubule in cardiac myocytesPrincipal Investigator
- Principal Investigator
  
  NAKADA Tsutomu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University
心室筋細胞のT管形成・維持におけるアンフィフィジン2の役割Principal Investigator
- Principal Investigator
  
  中田勉
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University

[Journal Article] Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin2023
- Author(s)
  Tanaka Yuki、Kadota Shin、Zhao Jian、Kobayashi Hideki、Okano Satomi、Izumi Masaki、Honda Yusuke、Ichimura Hajime、Shiba Naoko、Uemura Takeshi、Wada Yuko、Chuma Shinichiro、Nakada Tsutomu、Tohyama Shugo、Fukuda Keiichi、Yamada Mitsuhiko、Seto Tatsuichiro、Kuwahara Koichiro、Shiba Yuji
- Journal Title
  
  Stem Cell Research and Therapy
  
  Volume: 14 Issue: 1 Pages: 240-240
- DOI
  10.1186/s13287-023-03468-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06828, KAKENHI-PROJECT-23K06332, KAKENHI-PROJECT-23K07328, KAKENHI-PROJECT-21K08100, KAKENHI-PROJECT-22K19521, KAKENHI-PROJECT-23K21433
[Journal Article] NRSF- GNAO1 Pathway Contributes to the Regulation of Cardiac Ca 2+ Homeostasis2022
- Author(s)
  Inazumi Hideaki、Kuwahara Koichiro、Nakagawa Yasuaki、et al.
- Journal Title
  
  Circulation Research
  
  Volume: 130 Issue: 2 Pages: 234-248
- DOI
  10.1161/circresaha.121.318898
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07297, KAKENHI-PROJECT-19K08580, KAKENHI-PROJECT-19K16497, KAKENHI-PROJECT-20H03673, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07116, KAKENHI-PROJECT-19K07299, KAKENHI-PROJECT-21K08126, KAKENHI-PROJECT-20K17077, KAKENHI-PROJECT-22K08099
[Journal Article] A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery2022
- Author(s)
  Murayama Takashi、Kurebayashi Nagomi、Numaga-Tomita Takuro、Kobayashi Takuya、Okazaki Satoru、Yamashiro Kyosuke、Nakada Tsutomu、Mori Shuichi、Ishida Ryosuke、Kagechika Hiroyuki、Yamada Mitsuhiko、Sakurai Takashi
- Journal Title
  
  Journal of General Physiology
  
  Volume: 154 Issue: 12
- DOI
  10.1085/jgp.202213230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-22K06828, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K24067
[Journal Article] Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart2022
- Author(s)
  Kawagishi Hiroyuki、Nakada Tsutomu、Numaga-Tomita Takuro、Larran~aga Maite、Guo Ang、Song Long-Sheng、Yamada Mitsuhiko
- Journal Title
  
  American Journal of Physiology-Heart and Circulatory Physiology
  
  Volume: 323 Issue: 1 Pages: H103-H120
- DOI
  10.1152/ajpheart.00698.2021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06780, KAKENHI-PROJECT-19K07299
[Journal Article] Regulation of localization and function of L-type calcium channels by junctophilins2022
- Author(s)
  Nakada Tsutomu、Yamada Mitsuhiko
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 157 Issue: 1 Pages: 4-8
- DOI
  10.1254/fpj.21064
- NAID
  130008138778
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07299
[Journal Article] beta-Arrestin-Biased AT1 Agonist, TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect without Increasing Heart Rate2020
- Author(s)
  Kashihara T, Kawagishi H, Nakada T, Numaga-Tomita T, Kadota S, Wolf EE, Du CK, Shiba Y, Morimoto S, Yamada M.
- Journal Title
  
  Journal of the American College of Cardiology
  
  Volume: 5 Issue: 11 Pages: 1057-1057
- DOI
  10.1016/j.jacbts.2020.08.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07116, KAKENHI-PROJECT-19K07299, KAKENHI-PROJECT-18K06870, KAKENHI-PROJECT-19K16488
[Journal Article] Increase in phospholamban content in mouse skeletal muscle after denervation2018
- Author(s)
  Masatoshi Komatsu, Tsutomu Nakada, Hiroyuki Kawagishi, Hiroyuki Kato, Mitsuhiko Yamada.
- Journal Title
  
  Journal of Muscle Research and Cell Motility
  
  Volume: 39 Issue: 5-6 Pages: 163-173
- DOI
  10.1007/s10974-019-09504-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08491
[Journal Article] Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction2018
- Author(s)
  Nakada Tsutomu、Kashihara Toshihide、Komatsu Masatoshi、Kojima Katsuhiko、Takeshita Toshikazu、Yamada Mitsuhiko
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 17 Pages: 4507-4512
- DOI
  10.1073/pnas.1716649115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08491, KAKENHI-PROJECT-18K06870
[Journal Article] Molecular mechanism of junctional membrane-targeting of cardiac and skeletal muscle L-type calcium channels2014
- Author(s)
  中田　勉，山田　充彦
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 144 Issue: 5 Pages: 217-221
- DOI
  10.1254/fpj.144.217
- NAID
  130004704235
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-24590271
[Journal Article] Two mechanistically distinct effects of dihydro pyridine nifedipine on Ca^V〈1. 2〉L-type Ca^<2+> channels revealed by Timothy syndrome mutation2012
- Author(s)
  Sheng, X., Nakada, T., Kobayashi, M., Kashihara, T., Shibazaki, T., Horiuchi-Hirose, M., Gomi, S., Hirose, M., Aoyama, T., Yamada, M
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca^<2+> channel activity through phosphatases in heart failure2012
- Author(s)
  Kashihara, T., Nakada, T., Shimojo, H., Horiuchi-Hirose, M., Gomi, S., Shibazaki, T., Sheng, X., Hirose, M., Hongo, M., and Yamada, M
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol
  
  Volume: 302 Issue: 8 Pages: 1645-1654
- DOI
  10.1152/ajpheart.00589.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275, KAKENHI-PROJECT-22790206
[Journal Article] Diacylglycerol kinaseζinhibits ventricular tachyarrhythmias in a mou-se model of heart failure : Roles of canonical transient receptor potential(TRPC) channels2011
- Author(s)
  Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubotac I, Mende U, Yamada M.
- Journal Title
  
  Circ J
  
  Volume: 75 Pages: 2333-2342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590276
[Journal Article] Decrease in the density of t-tubular L-type Ca^<2+> channel currents in failing ventricular my cytes2011
- Author(s)
  Horiuchi-Hirose, M., Kashihara, T., Nakada, T., Kurebayashi, N., Shimojo, H., Shibazaki, T., Sheng, X., Yano, S., Hirose, M., Hongo, M., Sakurai, T., Moriizumi, T., Ueda, H., and Yamada, M
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol
  
  Volume: 300(3) Issue: 3 Pages: 978-988
- DOI
  10.1152/ajpheart.00508.2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] – Roles of Canonical Transient Receptor Potential (TRPC) Channels –2011
- Author(s)
  Hirose, M., Takeishi, Y., Niizeki, T., Nakada, T., Shimojo, H., Kashihara, T., Horiuchi-Hirose, M., Kubota, I., Mende, U., Yamada, M
- Journal Title
  
  Circ J
  
  Volume: 75 Issue: 10 Pages: 2333-2342
- DOI
  10.1253/circj.CJ-10-1213
- NAID
  10029459214
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275, KAKENHI-PROJECT-22790206
[Journal Article] Decrease in the density of t-tubular L-type Ca^<2+> channel currents in failing ventricular myocytes2011
- Author(s)
  Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol.
  
  Volume: 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790206
[Journal Article] Nicorandil ameliorates impulseconduction disturbances during ischemia in isolated arterially perfused canine atria2011
- Author(s)
  Hirose, M., Yano, S., Nakada, T., Horiuchi-irose, M., Tsujino, N., Yamada, M
- Journal Title
  
  Int. J. Cardiol
  
  Volume: 146 Issue: 1 Pages: 37-43
- DOI
  10.1016/j.ijcard.2009.06.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Diacylglycerol KinaseζInhibits Ventricular Tachyarrhythmias in a Mouse Model of Heart Failure2011
- Author(s)
  Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M.
- Journal Title
  
  Circ. J
  
  Volume: 75 Pages: 2333-2342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790206
[Journal Article] Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure : Roles of canonical transient receptor potential (TRPC) channels2011
- Author(s)
  Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubotac I, Mende U, Yamada M
- Journal Title
  
  Circulation Journal
  
  Volume: 75 Pages: 2333-2342
- NAID
  10029459214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590276
[Journal Article] Thrombin activates Ca^<2+>-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells2011
- Author(s)
  Tsujino, N, Nakada, T., Tsubouchi, K., Kobayashi, M., Kawai, Y., Yano, S., Matsunaga, T., Hirose, M., Ohmori, S., Ohhashi, T., Yamada, M
- Journal Title
  
  Shinshu Med. J
  
  Volume: 59 Pages: 13-26
- NAID
  130004810183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Selectiveα1A-adrenoceptor stimulation induces Mueller's smooth muscle contraction in an isolated canine upper eyelid preparation.2010
- Author(s)
  Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M
- Journal Title
  
  Curr. Eye Res. 35
  
  Pages: 363-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] Rhesus glycoprotein p2 (Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney.2010
- Author(s)
  Nakada T, Westhoff CM, Yamaguchi Y, Hyodo S, Li X, Muro T, Kato A, Nakamura N, Hirose S
- Journal Title
  
  J. Biol. Chem. 285
  
  Pages: 2653-2664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] 心不全誘発モデルマウスに対するニコランジル慢性投与の効果2010
- Author(s)
  弘瀬雅教、堀内美和、中田勉、柏原俊英、矢野志春、柴崎利英、生暁娜、山田充彦
- Journal Title
  
  Ther Res
  
  Volume: 31 Pages: 288-290
- Data Source
  KAKENHI-PROJECT-21590276
[Journal Article] Selectiveα_〈1A〉-adrenoceptor stimulation induces Mueller' s smooth muscle contraction in an isolated canine upper eyelid preparation2010
- Author(s)
  Yano, S., Hirose, M., Nakada, T., Nakayama, J., Matsuo, K., Yamada, M
- Journal Title
  
  Curr. Eye Res
  
  Volume: 35 Issue: 5 Pages: 363-369
- DOI
  10.3109/02713680903518858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Identification of renal transporters involved in sulfate excretion in marine teleost fish.2009
- Author(s)
  Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF
- Journal Title
  
  Am. J. Physiol. Regul. Integr. Comp. Physiol. 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] Diacylglycerol kinase ζ inhibits G α q-induced atrial remodeling in transgenic mice2009
- Author(s)
  Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.
- Journal Title
  
  Heart rhythm 6
  
  Pages: 78-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] Diaclglycerol seζinhibits G_〈αq〉-induced atrial remodeling in transgenic mice2009
- Author(s)
  Hirose, M., Takeishi, Y., Niizeki, T., Shimojo, H., Nakada, T., Kubota, I., Nakayama J., Mende, U., Yamada, M
- Journal Title
  
  Heart Rhythm
  
  Volume: 6 Pages: 78-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Diacylglycerol kinaseζinhibits Gαq-induced atrial remodeling in transgenic mice.2009
- Author(s)
  Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M
- Journal Title
  
  Heart rhythm 6
  
  Pages: 78-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] Contribution of L-type Ca^<2+> channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes2008
- Author(s)
  Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M.
- Journal Title
  
  J. Membr. Biol 222
  
  Pages: 151-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] Mechanisms of preventive effect of nicorandil on ischemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular.2008
- Author(s)
  Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M
- Journal Title
  
  Basic Clin. Pharmacol 102
  
  Pages: 504-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish.2008
- Author(s)
  Kurita Y, Nakada T, Kato A, Doi H, Mistry AC, Chang MH, Romero MF, Hirose S
- Journal Title
  
  Am. J. Physiol. Regul. Integr. Comp. Physiol. 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] Mechanisms of preventive effect of nicorandil on ischemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular2008
- Author(s)
  Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M.
- Journal Title
  
  Basic Clin. Pharmacol 102
  
  Pages: 504-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
- Author(s)
  Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M
- Journal Title
  
  Int. J. Cardiol. (In press)
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
- Author(s)
  Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M.
- Journal Title
  
  Int.J.Cardiol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Journal Article] Selective α1A-Adrenoceptor Stimulation Induces Mueller's Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation.
- Author(s)
  Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M
- Journal Title
  
  Curr.Eye Res (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790174
[Presentation] アンジオテンシンIIの新生児・乳児期特異的心臓作用の発見から小児心不全治療薬へ2024
- Author(s)
  川岸裕幸、中嶌岳郎、Risa Ramadhiani、中田勉、冨田拓郎、諫田泰成、江本憲昭、山田充彦
- Organizer
  第33回日本循環薬理学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06332
[Presentation] 横紋筋のジャンクトフィリンによるカルシウムチャネル調節機構2021
- Author(s)
  中田勉、川岸裕幸、冨田拓郎、山田充彦
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K07299
[Presentation] ジャンクトフィリンによるL型カルシウムチャネル調節機構2021
- Author(s)
  中田勉、川岸裕幸、冨田拓郎、山田充彦
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07299
[Presentation] 除神経モデルマウスの骨格筋におけるホスホランバンの発現量の増加2020
- Author(s)
  中田勉、小松雅俊、山田充彦
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K07299
[Presentation] 除神経モデルマウスの骨格筋におけるホスホランバンの発現量の増加2019
- Author(s)
  中田勉、小松雅俊、山田充彦
- Organizer
  第66回中部日本生理学会
- Data Source
  KAKENHI-PROJECT-19K07299
[Presentation] Interaction of junctophilins and the CaV1.1 is essential for the skeletal muscle contraction2019
- Author(s)
  Tsutomu Nakada
- Organizer
  The 9th Federation of the Asian and Oceanian Physiological Societies Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08491
[Presentation] Interaction of junctophilins and the C-terminus of CaV1.1 subunits regulates localization and function of L-type calcium channels in skeletal muscle.2017
- Author(s)
  Tsutomu Nakada, Masatoshi Komatsu, Toshihide Kashihara, Mitsuhiko Yamada
- Organizer
  Biophysical Society 61st Annual Meeting
- Place of Presentation
  New Orleans, USA
- Year and Date
  2017-02-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08491
[Presentation] Interaction of junctophilins and the C-terminus of CaV1.1 subunits regulates localization and function of L-type calcium channels in skeletal muscle.2017
- Author(s)
  Tsutomu Nakada
- Organizer
  20th International Symposium on Calcium Binding Proteins and Calcium Function In Health and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08491
[Presentation] 除神経骨格筋におけるL型カルシウムチャネルβサブユニットの発現増加2016
- Author(s)
  小松雅俊, 中田勉, 山本竜星, 柏原俊英, 山田充彦
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-25670641
[Presentation] ジャンクトフィリンはCaV1.1サブユニットのC末端と結合し，骨格筋L型カルシウムチャネルの局在を制御する2014
- Author(s)
  中田勉，Bernhard E Flucher，柏原俊英，小松雅俊，山田充彦
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] 横紋筋L型カルシウムチャネルの結合膜局在化機構2014
- Author(s)
  中田勉，Bernhard E Flucher，柏原俊英，小松雅俊，山田充彦
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] Junctophilin knockdown alters the localization and function of L-type calcium channels and ryanodine receptors in C2C12 myotubes.2013
- Author(s)
  Tsutomu Nakada, Bernhard Flucher, Toshihide Kashihara, Gomi Simmon, Mitsuhiko Yamada
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] Effect of junctophilin knockdown on the localization and function of L-type calcium channels and ryanodine receptors in skeletal myotubes.2013
- Author(s)
  Tsutomu Nakada, Bernhard Flucher, Toshihide Kashihara, Gomi Simmon, Mitsuhiko Yamada
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] L型カルシウムチャネルの結合膜局在化におけるジャンクトフィリンの役割2012
- Author(s)
  中田勉
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590275
[Presentation] L型カルシウムチャネルとリアノジン受容体の結合膜局在化におけるジャンクトフィリンの役割2012
- Author(s)
  中田勉, Bernhard E.Flucher, 柏原俊英, 生暁娜, 柴崎利英, 五味志文, 山田充彦
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-22790206
[Presentation] L型カルシウムチャネルとリアノジン受容体の結合膜局在化におけるジャンクトフィリンの役割2012
- Author(s)
  中田勉
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-21590275
[Presentation] Proximal C-terminus of α1C subunits is necessary for junctional membrane-targeting of cardiac L-type calcium channel2011
- Author(s)
  Nakada, T.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-21590275
[Presentation] Nicorandil inhibits Gaq-induced chronic heart failure in transgenic mice2011
- Author(s)
  Hirose M, Takeishi Y, Shimojo H, Kashihara T, Nakada T, Mende U, Hongo M, and Yamada M
- Organizer
  American Heart Association BCVS 2011
- Place of Presentation
  アメリカ(ニューオリンズ)
- Data Source
  KAKENHI-PROJECT-21590276
[Presentation] 心筋L型カルシウムチャネルの結合膜局在化モチーフの探索2011
- Author(s)
  中田勉, Bernhard E Flucher,生暁梛,柏原俊英,柴崎利英,山田充彦
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-16
- Data Source
  KAKENHI-PROJECT-22790206
[Presentation] 心筋L型カルシウムチャネルの結合膜局在化モチーフの探索2011
- Author(s)
  中田勉, 他
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜(誌上開催)
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-21590275
[Presentation] Proximal C-terminus of alC subunits is necessary for junctional membrane-targeting of cardiac L-type calcium channels2011
- Author(s)
  Tsutomu Nakada, Bernhard E.Flucher, Toshihide Kashihara, Xiaona Sheng, Toshihide Shibazaki, Miwa Horiuchi-Hirose, Masamichi Hirose, Mitsuhiko Yamada
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22790206
[Presentation] Olmesartan inhibits atrial remodeling in a mouse model of chronic heart failure2011
- Author(s)
  弘瀬雅教, 竹石恭知, 下条久志, 柏原俊英, 中田勉, 中山貢一, 山田充彦
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590276
[Presentation] Nicorandil inhibits G alpha q-induced chronic heart failure in transgenic mice2011
- Author(s)
  弘瀬雅教, 竹石恭知, 柏原俊英, 中田勉, 山田充彦
- Organizer
  第75回日本循環器学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590276
[Presentation] GLT細胞を用いた心筋L型Ca^<2+>チャネルのクラスタリング機構の解析2010
- Author(s)
  中田勉, Bernhard E Flucher, 生暁娜, 柏原俊英, 柴崎利英, 山田充彦
- Organizer
  第123回日本薬理学会関東部会
- Place of Presentation
  栃木
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-22790206
[Presentation] 不完全心室筋細胞のT管のL型Ca2+チャネル電流密度の減少に百日咳毒素感受性G蛋白質(Gi/o)が果たす役割2010
- Author(s)
  柏原俊英, 呉林なごみ, 堀内美和, 中田勉, 生暁娜, 弘瀬雅教, 山田充彦
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790174
[Presentation] GLT細胞を用いた心筋L型Ca^<2+>チャネルのクラスタリング機構の解析2010
- Author(s)
  中田勉, 他
- Organizer
  第123回日本薬理学会関東部会
- Place of Presentation
  栃木
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-21590275
[Presentation] ニフェジピンは超遅延性膜電位依存性不活性化を安定化してL型Ca2+チャネルを抑制する2010
- Author(s)
  生暁娜, 中田勉, 柏原俊英, 弘瀬雅教, 青山俊文, 山田充彦
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790174
[Presentation] Olmesartan inhibits G proteinαq-induced atrial remodeling in transgenic mice2010
- Author(s)
  Hirose M, Takeishi Y, Shimojo H, Kashihara T, Nakada T, Mende U, Hongo M, and Yamada M
- Organizer
  83th American Heart Association Scientific Sessions 2010
- Place of Presentation
  アメリカ(シカゴ)
- Data Source
  KAKENHI-PROJECT-21590276
[Presentation] イソプロテレノール誘発性心肥大によるT管L型カルシウム電流密度の変化2009
- Author(s)
  堀内美和, 植田秀穂, 中田勉, 弘瀬雅教, 山田充彦
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790174
[Presentation] Nicorandil Inhibits Ventricular Remodeling and Arrhythmias in a Mouse Model of Chronic Heart Failure2009
- Author(s)
  Hirose M, Takeishi Y, Shimojo H, Nishio A, Nakada T, Kubota I, Mende U, Hongo M, Matsumoto K, and Yamada M
- Organizer
  82th American Heart Association Scientific Sessions
- Place of Presentation
  アメリカ(オーランド)
- Data Source
  KAKENHI-PROJECT-21590276
[Presentation] DGKζは, 活性型Gプロテインαq強発現マウスの心房細動発生を抑制する2009
- Author(s)
  弘瀬雅教, 竹石恭知, 新関武史, 久保田功, 中田勉, 山田充彦
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790174
[Presentation] Activation of TRPC channels participates in the induction of ventricular arrhythmias in a mouse model of congestive heart failure2009
- Author(s)
  Hirose M, Takeishi Y, Niizeki T, Horiuchi-Hirose M, Nakada T, Kubota M, Ulrike M, Yamada M
- Organizer
  Heart Failure 2009 and The Annual Congress of ISHR European section
- Place of Presentation
  フランス(ニース)
- Data Source
  KAKENHI-PROJECT-21590276
[Presentation] CaV1.1 のジャンクトフィリン結合ドメインへの点変異導入は、骨格筋 L 型カルシウムチャネルの結合膜構造への集積を阻害する
- Author(s)
  中田　勉
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-24590271

1. YAMADA Mitsuhiko (10263237)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. HIROSE Masamichi (40273081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. TAKEISHI Yasuchika (40272067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. KASHIHARA Toshihide (20552334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. SUZUKI Suechika (10082174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KATO Hiroyuki (40204490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. UCHIYAMA Shigeharu (10242679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HIGUCHI Keiichi (20173156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Ishida Takashi (60531952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 清澤研吉 (50624772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 木村忠史 (60344214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 国広なごみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 石田良典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 川岸裕幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 冨田拓郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKADA TSUTOMU 中田 勉

NAKADA Tsutomu 中田 勉

Research Projects

Research Products

Co-Researchers

Analyses of the molecular mechanism underlying and the functional significance of developmental changes in intracellular signal transduction systems coupled to cardiac AT1 receptors.

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組織特異的ノックアウト手法を用いた骨格筋ジャンクトフィリンのサブタイプ別機能解析Principal Investigator

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Role of junctophilin degradation in the formation of heart failurePrincipal Investigator

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Development of novel Nav1.7 antagonist by using molecular pharmacological methods

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Role of junctophilins on excitation-contraction coupling of skeletal musclesPrincipal Investigator

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Changes in expression of L-type calcium channel subunits in skeletal muscle with aging.

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Localization and function of L-type calcium channels in skeletal muscle is regulated by junctophilins.Principal Investigator

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Junctional membrane-targeting mechanism of cardiac L-type calcium channelPrincipal Investigator

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Quantitative analysis of the open-state affinity of L-type calcium channel blockers and modeling of their inhibitory actions

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Roles of TRPC channel activation in the induction of ventricular tachycardias

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Analysis of molecules related to structure and function of T-tubule in cardiac myocytesPrincipal Investigator

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心室筋細胞のT管形成・維持におけるアンフィフィジン2の役割Principal Investigator

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[Journal Article] Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin2023

Author(s)

Journal Title

NAKADA TSUTOMU 中田勉

NAKADA Tsutomu 中田勉

[Journal Article] – Roles of Canonical Transient Receptor Potential (TRPC) Channels –2011