Haga Hiroaki 芳賀弘明

Researcher Number	70466613
Other IDs	https://orcid.org/0000-0001-9355-1837
Affiliation (Current)	2025: 山形大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 山形大学, 医学部, 准教授 2022 – 2023: 山形大学, 医学部, 准教授 2021: 山形大学, 医学部, 講師 2016 – 2018: 山形大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator Extracellular Vesicles / 間葉系幹細胞 / 細胞外小胞 / 急性肝不全 / 再生医学 / Extracellular vesicles / 肝幹細胞 Except Principal Investigator 慢性肝炎 / 肝線維化 / 肝内神経線維 … More / 非アルコール性脂肪性肝炎 / 非アルコール性脂肪肝炎 / Epiregulin / 肝再生 / 脂肪肝 Less

Xeno-Freeヒト間葉系幹細胞由来細胞外小胞の凍結乾燥保存法と急性肝不全治療法の開発Principal Investigator
- Principal Investigator
  
  芳賀弘明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Yamagata University
脂肪性肝疾患を背景とした肝線維化過程への肝再生関連増殖因子の関与機構の解明
- Principal Investigator
  
  星川恭子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Yamagata University
Establishment of a Preservation Method for Mesenchymal Stem Cell-Derived Extracellular Vesicles and Development of a Novel Treatment for Acute Liver FailurePrincipal Investigator
- Principal Investigator
  
  Haga Hiroaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Yamagata University
Intrahepatic innervation and pathogenesis of chronic liver disease
- Principal Investigator
  
  Mizuno Kei
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Yamagata University
Novel treatment for acute liver failure by hepatic stem cells derived EVPrincipal Investigator
- Principal Investigator
  
  Haga Hiroaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University

All 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Intrahepatic distribution of nerve fibers and alterations due to fibrosis in diseased liver2021
- Author(s)
  Kei Mizuno, Hiroaki Haga, Kazuo Okumoto, Kyoko Hoshikawa, Tomohiro Katsumi, Taketo Nishina, Takafumi Saito, Hideki Katagiri, Yoshiyuki Ueno
- Journal Title
  
  PLoS One
  
  Volume: 16(4) Issue: 4 Pages: e0249556-e0249556
- DOI
  10.1371/journal.pone.0249556
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08373, KAKENHI-PROJECT-19K10898
[Journal Article] Incidence of development of hepatocellular carcinoma in Japanese patients infected with hepatitis B virus are equivalent between genotype B and C in long term.2019
- Author(s)
  Haga H, Saito T, Okumoto K, Tomita K, Katsumi T, Mizuno K, Nishina T, Watanabe H, Ueno Y.
- Journal Title
  
  Journal of Viral Hepatitis
  
  Volume: 印刷中 Issue: 7 Pages: 866-872
- DOI
  10.1111/jvh.13099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09338
[Journal Article] Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice2017
- Author(s)
  Haga H, Yan IK, Takahashi K, Matsuda A, Patel T
- Journal Title
  
  Stem Cells Translational Medicine
  
  Volume: 6 Pages: 1262-1272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09338
[Journal Article] Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury.2017
- Author(s)
  Haga H, Yan IK, Borrelli DA, Matsuda A, Parasramka M, Shukla N, Lee DD, Patel T
- Journal Title
  
  Liver Transplantation
  
  Volume: 23 Pages: 791-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09338
[Journal Article] Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice.2017
- Author(s)
  Haga H, Yan IK, Takahashi K, Matsuda A, Patel T.
- Journal Title
  
  Stem Cells Transl Med.
  
  Volume: 6 Issue: 4 Pages: 1262-1272
- DOI
  10.1002/sctm.16-0226
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09338
[Journal Article] Circulating Extracellular RNA Markers of Liver Regeneration.2016
- Author(s)
  Yan IK, Wang X, Asmann YW, Haga H, Patel T.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 7 Pages: e0155888-e0155888
- DOI
  10.1371/journal.pone.0155888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09338
[Journal Article] MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cirrhosis2016
- Author(s)
  Katsumi T, Ninomiya M, Nishina T, Mizuno K,　Tomita K, Haga H, Okumoto K, Saito T, Shimosegawa T, Ueno Y
- Journal Title
  
  Lab Invest
  
  Volume: 96 Issue: 11 Pages: 1165-1177
- DOI
  10.1038/labinvest.2016.95
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08983, KAKENHI-PROJECT-16K09338
[Presentation] Stem cell由来Extracellular Vesiclesを用いた急性肝障害に対する治療法の開発2018
- Author(s)
  芳賀弘明上野義之
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] DAA 治療成功例でのC 型肝炎患者の肝線維化改善例および悪化例のメタボローム解析2018
- Author(s)
  芳賀弘明、齋藤貴史、奥本和夫、冨田恭子、水野恵、仁科武人、上野義之
- Organizer
  抗ウイルス療法学会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] Specific Metaboromic Factors Were Involved in Hepatic Fibrosis Progression after Svr Achievement in HCV Infection2018
- Author(s)
  Haga, H, Saito, T, Okumoto, K, Tomita, K, Mizuno, K, Nishina, T, Ueno, Y
- Organizer
  AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] HBV 遺伝子型 Subtype Bj 患者の長期予後の検討＜Subtype Bj 患者の発癌リスクは決して低くない＞2018
- Author(s)
  芳賀弘明、奥本和夫、上野義之
- Organizer
  日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] Artificial Intelligence (AI) Accurately Predicts the Daa-Treatment Outcomes Using Algorithms from Unique Variants of HCV2018
- Author(s)
  Haga, H, Sato, H, Koseki, A, Okumoto, K, Tomita, K, Mizuno, K, Nishina, T, Saito, T, Ueno, Y
- Organizer
  AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] マシーンラーニング（AI）を用いたHCVゲノム解析によるDAA効果予測判定システムの構築2018
- Author(s)
  芳賀弘明、奥本和夫、上野義之
- Organizer
  日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] C型肝炎患者でのDAA治療成功例における肝線維化改善例および悪化例のメタボローム解析2018
- Author(s)
  芳賀弘明, 齋藤貴史, 仁科武人, 水野恵, 冨田恭子, 奥本和夫, 上野義之
- Organizer
  JDDW
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] C型肝炎患者でのDAA治療成功例におけるFIB4-indexの推移とメタボローム解析2018
- Author(s)
  芳賀弘明、奥本和夫、上野義之
- Organizer
  日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] Establishment of Automated Whole Genome Sequencing of Entire HCV Genome and Its Implication for Clinical Outcome of DAA Treatment2018
- Author(s)
  Haga, H, Sato, H, Koseki, A, Okumoto, K, Tomita, K, Mizuno, K, Nishina, T, Saito, T, Ueno, Y
- Organizer
  DDW
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] 間葉系幹細胞由来Extracellular Vesiclesは肝虚血再灌流マウスモデルの肝障害を軽減させる2017
- Author(s)
  芳賀弘明, 上野義之
- Organizer
  日本細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] HBV遺伝子型からみた核酸アナログ治療の発癌および長期予後2017
- Author(s)
  芳賀弘明, 斎藤貴史, 上野義之
- Organizer
  日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] RAV測定を採用した肝炎地域ネットワークにおけるC型肝炎インターフェロンフリー治療の治療成績2017
- Author(s)
  芳賀弘明, 齋藤貴史, 上野義之
- Organizer
  日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] B型慢性肝疾患におけるHBV遺伝子型からみた肝発癌の検討.2017
- Author(s)
  芳賀弘明, 奥本和夫, 勝見智大, 水野恵, 上野義之
- Organizer
  日本消化器病学会東北支部例会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] 放射線照射療法および粒子線照射療法による難治性肝細胞癌の治療効果の検討2017
- Author(s)
  芳賀弘明, 奥本和夫, 仁科武人, 水野恵, 勝見智大, 齋藤貴史, 上野義之
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] 難治性肝細胞癌に対する放射線照射療法および粒子線照射療法の検討2017
- Author(s)
  芳賀弘明, 奥本和夫, 勝見智大, 齋藤貴史, 上野義之
- Organizer
  日本消化器病学会東北支部例会
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] Whole Genome Sequencing (WGS)を用いたHCV全ゲノム塩基解読によるDAA耐性との関連を可視化させる新規技術の開発2017
- Author(s)
  芳賀弘明, 奥本和夫, 上野義之
- Organizer
  JDDW
- Data Source
  KAKENHI-PROJECT-16K09338
[Presentation] Efficacy and magnitude of resistance-associated variants (RAVs) in Daclatasvir/Asnaprevir combination therapy2017
- Author(s)
  Haga H, Saito T, Okumoto K, Katsumi T, Mizuno K, Nishina T, Ueno Y
- Organizer
  APASL
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09338

1. Mizuno Kei (00715394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. 星川恭子 (20613053)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 邵力 (80344787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 勝見智大 (70637355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 斎藤貴史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Haga Hiroaki 芳賀 弘明

Research Projects

Research Products

Co-Researchers

Xeno-Freeヒト間葉系幹細胞由来細胞外小胞の凍結乾燥保存法と急性肝不全治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂肪性肝疾患を背景とした肝線維化過程への肝再生関連増殖因子の関与機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a Preservation Method for Mesenchymal Stem Cell-Derived Extracellular Vesicles and Development of a Novel Treatment for Acute Liver FailurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intrahepatic innervation and pathogenesis of chronic liver disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel treatment for acute liver failure by hepatic stem cells derived EVPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Intrahepatic distribution of nerve fibers and alterations due to fibrosis in diseased liver2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Incidence of development of hepatocellular carcinoma in Japanese patients infected with hepatitis B virus are equivalent between genotype B and C in long term.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice2017

Author(s)

Journal Title

Data Source

[Journal Article] Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury.2017

Author(s)

Journal Title

Data Source

[Journal Article] Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating Extracellular RNA Markers of Liver Regeneration.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cirrhosis2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] Stem cell由来Extracellular Vesiclesを用いた急性肝障害に対する治療法の開発2018

Author(s)

Organizer

Data Source

[Presentation] DAA 治療成功例でのC 型肝炎患者の肝線維化改善例および悪化例のメタボローム解析2018

Author(s)

Organizer

Data Source

[Presentation] Specific Metaboromic Factors Were Involved in Hepatic Fibrosis Progression after Svr Achievement in HCV Infection2018

Author(s)

Organizer

Data Source

[Presentation] HBV 遺伝子型 Subtype Bj 患者の長期予後の検討 ＜Subtype Bj 患者の発癌リスクは決して低くない＞2018

Haga Hiroaki 芳賀弘明

[Presentation] HBV 遺伝子型 Subtype Bj 患者の長期予後の検討＜Subtype Bj 患者の発癌リスクは決して低くない＞2018