Kosaka Tomoyuki 高坂智之

… Alternative Names

KOSAKA Tomouki 高坂智之

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Researcher Number	70500453
Other IDs	https://orcid.org/0000-0002-8181-9127
Affiliation (Current)	2025: 山口大学, 大学研究推進機構 , 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 山口大学, 大学研究推進機構, 准教授 2020: 山口大学, 大学院創成科学研究科, 准教授 2017 – 2018: 山口大学, 大学院創成科学研究科, 助教 2016: 山口大学, 創成科学研究科, 助教 2015: 山口大学, 農学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 38020:Applied microbiology-related / Applied microbiology Except Principal Investigator Basic Section 61030:Intelligent informatics-related / System genome science
Keywords	Principal Investigator コハク酸デヒドロゲナーゼ / プロピオン酸酸化細菌 / コハク酸脱水素酵素 / 酵素成熟化遺伝子 / プロピオン酸代謝 / 補酵素 / 成熟化遺伝子 / 膜タンパク質 / ヒドロゲナーゼ / 異種発現 … More / 大腸菌 / 成熟化因子 / ゲノム情報 / 高温メタン発酵 / コハク酸酸化 / 微生物代謝 / 水素放出 / サブユニット構造 / 大腸菌異種発現 / プロピオン酸酸化 / 膜電位 / 水素生成 / フマル酸還元酵素 / メタン発酵 / 共生的プロピオン酸酸化 … More Except Principal Investigator 生育結合 / 流束均衡解析 / 増殖連動型生産 / 線形計画問題 / 遺伝子削除問題 / 反応削除問題 / 制約モデル / ゲノムスケールモデル / 遺伝子削除 / 微生物 / GPRルール / 遺伝子削除戦略 / 代謝ネットワーク設計 / ゲノムスケール代謝モデル / 混合整数線形計画法 / アルゴリズム / 増殖連動生産 / 有用物質生産 / 代謝ネットワーク / 細胞内ネットワーク / 遺伝的ネットワーク / 二重欠失株 / Chemical Genomics / Multiplex解析 / population変動 / 貞コピー可動型発現プラスミド / deep sequence / 一遺伝子欠失株 / 分子バーコード / 大腸菌 / ケミカルバイオロジー / 長期定常期 / 大腸菌population変動解析 / バーコード解析 / deep sequencing / stationary phase / chemical genomics / population dynamics / deletion collection / bar-code / E. coli Less

Search and functional analysis of maturation genes for syntrophic propionate oxidation using genomic informationPrincipal Investigator
- Principal Investigator
  
  Kosaka Tomoyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Yamaguchi University
Algorithms for metabolic network design for efficient production of valuable substances
- Principal Investigator
  
  田村武幸
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 61030:Intelligent informatics-related
- Research Institution
  Kyoto University
Elucidation of hydrogen production mechanisms from succinate oxidation in a thermophilic propionate oxidizing bacteriumPrincipal Investigator
- Principal Investigator
  
  Kosaka Tomoyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  Yamaguchi University
Strategy of a cell to survive during a long term stationary phase before cell proliferation.
- Principal Investigator
  
  Mori Hirotada
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  System genome science
- Research Institution
  Nara Institute of Science and Technology

All 2024 2023 2022 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Membrane Potential-requiring Succinate Dehydrogenase Constitutes the Key to Propionate Oxidation and Is Unique to Syntrophic Propionate-oxidizing Bacteria2023
- Author(s)
  Kosaka Tomoyuki、Tsushima Yuka、Shiota Yusuke、Ishiguchi Takayuki、Matsushita Kazuo、Matsutani Minenosuke、Yamada Mamoru
- Journal Title
  
  Microbes and Environments
  
  Volume: 38 Issue: 2 Pages: n/a
- DOI
  10.1264/jsme2.ME22111
- ISSN
  1342-6311, 1347-4405
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05343
[Journal Article] Gene Deletion Algorithms for Minimum Reaction Network Design by Mixed-Integer Linear Programming for Metabolite Production in Constraint-Based Models: gDel_minRN2023
- Author(s)
  Tamura Takeyuki、Muto-fujita Ai、Tohsato Yukako、Kosaka Tomoyuki
- Journal Title
  
  Journal of Computational Biology
  
  Volume: 30 Issue: 5 Pages: 553-568
- DOI
  10.1089/cmb.2022.0352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20386
[Journal Article] An aggregation-defective mutant of Methanothermobacter sp. CaT2 reveals a unique protein-dependent aggregation2019
- Author(s)
  Kana Sumikawa, Tomoyuki Kosaka, Noriaki Mayahara, Minenosuke Matsutani, Koichi Udo and Mamoru Yamada
- Journal Title
  
  Microbes and Environments
  
  Volume: ー
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07666
[Journal Article] Flagellum-mediated motility in Pelotomaculum thermopropionicum SI2019
- Author(s)
  Kosaka Tomoyuki、Goda Mutsumi、Inoue Manami、Yakushi Toshiharu、Yamada Mamoru
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: - Issue: 7 Pages: 1-10
- DOI
  10.1080/09168451.2019.1597618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07666
[Presentation] 大腸菌での異種ギ酸トランスポーターのギ酸取り込み能の機能解析法の検討とその適応2024
- Author(s)
  矢原拓弥, 高坂智之
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-21K05343
[Presentation] ゲノム情報解析による遺伝子の機能に関与する遺伝子群の抽出と可視化2023
- Author(s)
  高坂智之, 松谷峰之介
- Organizer
  日本微生物生態学会第36回浜松大会
- Data Source
  KAKENHI-PROJECT-21K05343
[Presentation] 異種発現によるグラム陽性細菌コハク酸脱水素酵素のFAD共有結合機構の解析2023
- Author(s)
  塩田悠介, 高坂智之
- Organizer
  日本微生物生態学会第36回浜松大会
- Data Source
  KAKENHI-PROJECT-21K05343
[Presentation] 大腸菌における異種コハク酸脱水素酵素の発現と機能化の比較2022
- Author(s)
  塩田悠介, 高坂智之
- Organizer
  第74回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-21K05343
[Presentation] Gene deletion algorithms for minimum reaction network design by mixed-integer linear programming for metabolite production in constraint-based models: gDel_minRN2021
- Author(s)
  Takeyuki Tamura, Ai Muto-Fujita, Yukako Tohsato and Tomoyuki Kosaka
- Organizer
  第10回生命医薬情報学連合大会
- Data Source
  KAKENHI-PROJECT-23K20386
[Presentation] 高温性プロピオン酸酸化細菌のプロピオン酸代謝におけるコハク酸脱水素酵素の生理的役割2018
- Author(s)
  津島由佳、石口貴之、高坂智之、山田守
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-16K07666
[Presentation] プロピオン酸酸化細菌のプロピオン酸酸化からの水素生成に関与する因子の探索2017
- Author(s)
  高坂智之、津島由佳、石口貴之、山田守
- Organizer
  日本農芸化学会2017年度(平成29年度)大会
- Place of Presentation
  京都府京都市、京都女子大
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-16K07666
[Presentation] 高温性プロピオン酸酸化細菌のコハク酸酸化に関与する酵素の機能的特徴2017
- Author(s)
  津島由佳、石口貴之、高坂智之、山田守
- Organizer
  日本農芸化学会中四国支部第47回講演会（例会）
- Place of Presentation
  島根県松江市、島根大学
- Year and Date
  2017-01-28
- Data Source
  KAKENHI-PROJECT-16K07666
[Presentation] 大腸菌が耐熱性向上のために獲得した変異の解析2016
- Author(s)
  加藤薫平石井あやな村田正之高坂智之山田守
- Organizer
  日本農芸化学会中四国支部第44回講演会（例会）
- Place of Presentation
  東京工業大学, 東京
- Year and Date
  2016-01-23
- Data Source
  KAKENHI-PROJECT-25250028

1. TOHSATO Yukari (80346171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. TAMURA Takeyuki (00437261)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. Mori Hirotada (90182203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YAMADA Mamoru (30174741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MATSUNO Hiroshi (10181744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MAKI Yasushi (60401733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAHIGASHI Kenji (70322740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAITO Natsumi (50287546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 片岡正和 (90332676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松谷峰之介 (70380558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 武藤愛 (80730506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Kosaka Tomoyuki 高坂 智之

KOSAKA Tomouki 高坂 智之

Research Projects

Research Products

Co-Researchers

Search and functional analysis of maturation genes for syntrophic propionate oxidation using genomic informationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Algorithms for metabolic network design for efficient production of valuable substances

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of hydrogen production mechanisms from succinate oxidation in a thermophilic propionate oxidizing bacteriumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Strategy of a cell to survive during a long term stationary phase before cell proliferation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Membrane Potential-requiring Succinate Dehydrogenase Constitutes the Key to Propionate Oxidation and Is Unique to Syntrophic Propionate-oxidizing Bacteria2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Gene Deletion Algorithms for Minimum Reaction Network Design by Mixed-Integer Linear Programming for Metabolite Production in Constraint-Based Models: gDel_minRN2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An aggregation-defective mutant of Methanothermobacter sp. CaT2 reveals a unique protein-dependent aggregation2019

Author(s)

Journal Title

Data Source

[Journal Article] Flagellum-mediated motility in Pelotomaculum thermopropionicum SI2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 大腸菌での異種ギ酸トランスポーターのギ酸取り込み能の機能解析法の検討とその適応2024

Author(s)

Organizer

Data Source

[Presentation] ゲノム情報解析による遺伝子の機能に関与する遺伝子群の抽出と可視化2023

Author(s)

Organizer

Data Source

[Presentation] 異種発現によるグラム陽性細菌コハク酸脱水素酵素のFAD共有結合機構の解析2023

Author(s)

Organizer

Data Source

[Presentation] 大腸菌における異種コハク酸脱水素酵素の発現と機能化の比較2022

Author(s)

Organizer

Data Source

[Presentation] Gene deletion algorithms for minimum reaction network design by mixed-integer linear programming for metabolite production in constraint-based models: gDel_minRN2021

Author(s)

Organizer

Data Source

[Presentation] 高温性プロピオン酸酸化細菌のプロピオン酸代謝におけるコハク酸脱水素酵素の生理的役割2018

Author(s)

Organizer

Data Source

[Presentation] プロピオン酸酸化細菌のプロピオン酸酸化からの水素生成に関与する因子の探索2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Kosaka Tomoyuki 高坂智之

KOSAKA Tomouki 高坂智之