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Hatakeyama Hiroto  畠山 浩人

… Alternative Names

HATAKEYAMA Hiroto  畠山 浩人

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Researcher Number 70504786
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3899-0508
External Links
Affiliation (Current) 2025: 千葉大学, 大学院薬学研究院, 教授
Affiliation (based on the past Project Information) *help 2022 – 2024: 千葉大学, 大学院薬学研究院, 教授
2019 – 2021: 千葉大学, 大学院薬学研究院, 准教授
2016 – 2018: 千葉大学, 大学院薬学研究院, 助教
2013: 北海道大学, 薬学研究科(研究院), その他
2012: 北海道大学, 薬学研究科(研究院), 特任助教
2009 – 2011: Hokkaido University, 大学院・薬学研究院, 特任助教
2008: Hokkaido University, 大学院・薬学研究院, 助教
Review Section/Research Field
Principal Investigator
Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Transformative Research Areas, Section (II) / Science and Engineering
Except Principal Investigator
Medical pharmacy / Biological Sciences
Keywords
Principal Investigator
免疫チェックポイント阻害剤 / 核酸医薬 / がん治療 / がん / siRNA / 脂質ナノ粒子 / 腹膜播種 / 腹腔内投与 / 温熱療法 / 温熱治療 … More / 抗体医薬 / ドラッグデリバリーシステム / 多機能性エンベロープ型ナノ構造体 / ドラッグデリバリー / 間質 / 細胞外マトリックス / mRNA医薬 / 担癌モデル / アナフィラキシー / 抗薬物抗体 / KPCマウス / がん免疫治療 / DDS / 膵癌 / 腫瘍微小環境 / 代謝 / CTGF / ユビキチン / トランスオミクス / CE-TOFMS / 代謝アダプテーション / 温熱耐性 / 免疫治療 / PD-1 / 薬物動態学 / 癌 / 肝炎 / リポソーム / 癌治療 / anti-miRNA oligo / miRNA / 膜融合性ペプチド / 細胞内動態制御 / 膜融合ペプチド / siRNAデリバリー … More
Except Principal Investigator
数理モデル / PK-PD / モデル基盤メタ・アナリシス / 第 Xa 因子阻害 / 心房細動 / 大出血 / 脳梗塞 / PT-INR / PK/PDモデル / 大規模臨床試験 / PPK/PDモデル / 血栓形成 / 用量最適化 / 血流量 / プロトロンビン時間 / PK-PDモデル / PPK-PDモデル / イベントリスク / モデル基盤メタアナリシス / 第Xa因子阻害剤 / 抗腫瘍効果 / エンドソーム脱出 / PPD / 多機能性エンベロープ型ナノ構造体 / デリバリーシステム / MEND / ワクチン / siRNA / 遺伝子治療 / がん Less
  • Research Projects

    (10 results)
  • Research Products

    (199 results)
  • Co-Researchers

    (13 People)
  •  腹腔内移行経路による腫瘍微小環境編集と難治性腹膜播種治療への展開Principal Investigator

    • Principal Investigator
      畠山 浩人
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Chiba University
  •  Investigation of mechanism for production of anti-drug antibody against immune checkpoint inhibitorsPrincipal Investigator

    • Principal Investigator
      畠山 浩人
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Chiba University
  •  Development of a novel hyperthermic immunotherapy by selective delivery of nano-DDS and therapeutic molecules for pancreas cancer treatmentPrincipal Investigator

    • Principal Investigator
      Hiroto Hatakeyama
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Chiba University
  •  がん細胞および腫瘍微小環境の温熱耐性応答メカニズムの解明Principal Investigator

    • Principal Investigator
      畠山 浩人
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      Chiba University
  •  Model based meta-analysis and establishment of PBPK model for appropriate use of factor Xa inhibitor

    • Principal Investigator
      Sato Hiromi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Chiba University
  •  Evaluation of Pharmacokinetic and efficacy of Anti-PD-1/PD-L1 Antibodies and development of PBPK models.Principal Investigator

    • Principal Investigator
      Hatakeyama Hiroto
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Medical pharmacy
    • Research Institution
      Chiba University
  •  細胞ナノ領域と生体微小環境における核酸送達システムの動態と機能発現解析Principal Investigator

    • Principal Investigator
      畠山 浩人
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      Hokkaido University
  •  Development of a microRNA delivery system for cancer therapyPrincipal Investigator

    • Principal Investigator
      HATAKEYAMA Hiroto
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Hokkaido University
  •  Multifunctional Envelope-type Nano Device as non-viral gene delivery system for cancer therapy

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Development of siRNA delivery system with programmed tumor activationPrincipal Investigator

    • Principal Investigator
      HATAKEYAMA Hiroto
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Medical pharmacy
    • Research Institution
      Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book Patent

  • [Book] Cancer Drug Delivery Systems Based on the Tumor Microenvironment2019

    • Author(s)
      Khalil IA, Hatakeyama H, Nakamura T, Harashima H
    • Total Pages
      319
    • Publisher
      Springer
    • ISBN
      9784431568803
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Book] Cancer Drug Delivery Systems Based on the Tumor Microenvironment2019

    • Author(s)
      Khalil IA, Hatakeyama H, Nakamura T, Harashima H
    • Total Pages
      319
    • Publisher
      Springer
    • ISBN
      9784431568803
    • Data Source
      KAKENHI-PUBLICLY-18H04686
  • [Book] 応用が広がるDDS2013

    • Author(s)
      秋田英万、山田勇磨、畠山浩人、林康弘、原島秀吉
    • Total Pages
      578
    • Publisher
      エヌ・ティー・エス
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Book] ドラッグデリバリーシステムの新展開II -核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術-2012

    • Author(s)
      畠山浩人、秋田英万、原島秀吉
    • Total Pages
      278
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Book] Comprehensive Biomaterials2011

    • Author(s)
      Akita H, Hatakeyama H, Khalil IA, Yamada Y, Harashima H
    • Total Pages
      3750
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Book] Delivery of Nucleic Acids and Gene Delivery2011

    • Author(s)
      Akita H, Hatakeyama H, et al.
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Book] 蛍光イメージング/MRIプローブの開発2011

    • Author(s)
      秋田英万、山田勇磨、中村孝司、畠山浩人、林泰弘、梶本和昭、原島秀吉
    • Total Pages
      196
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Book] Adv Biochem Eng Biotechnol(A Novel Nonviral Gene Delivery System: Multifunctional Envelope-Type Nano Device.)2009

    • Author(s)
      H.Hatakeyama, H.Akita, K.Kogure, H.Harashima
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Book] A Novel Nonviral Gene Delivery System: Multifunctional Envelope-Type Nano Device2009

    • Author(s)
      H. Hatakeyama, H. Akita, K. Kogure, H. Harashima
    • Publisher
      Adv Biochem Eng Biotechnol
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Book] 細胞内動態の制御を可能とする多機能性エンベロープ型ナノ構造体による遺伝子導入(遺伝子医学MOOK別冊「ますます重要になる細胞周辺環境(細胞ニッチ)の最新科学技術」)

    • Author(s)
      畠山浩人, 原島秀吉
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Journal Article] Delivery of aPD-L1 antibody to i.p. tumors via direct penetration by i.p. route: beyond EPR effect.2022

    • Author(s)
      M. Yamamoto, T. Kurino, R. Matsuda, H. S. Jones, Y. Nakamura, T. Kanamori, A. B. Tsuji, A. Sugyo, R. Tsuda, Y. Matsumoto, Y. Sakurai, H. Suzuki, M. Sano, K. Osada, T. Uehara, Y. Ishii, H. Akita, Y. Arano, A. Hisaka, H. Hatakeyama,
    • Journal Title

      Journal of Controlled Release

      Volume: 352 Pages: 328-337

    • DOI

      10.1016/j.jconrel.2022.10.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K19014, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-23K21857, KAKENHI-PROJECT-23K24041
  • [Journal Article] Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor2022

    • Author(s)
      Arai Takahiro、Kokubo Tomomi、Tang Ruiheng、Abo Hirohito、Terui Ayu、Hirakawa Jotaro、Akita Hidetaka、Kawashima Hiroto、Hisaka Akihiro、Hatakeyama Hiroto
    • Journal Title

      Journal for ImmunoTherapy of Cancer

      Volume: 10 Issue: 12 Pages: e005657-e005657

    • DOI

      10.1136/jitc-2022-005657

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-21H05506, KAKENHI-PROJECT-20H03379, KAKENHI-PROJECT-20K15986
  • [Journal Article] Combined nano cancer immunotherapy based on immune status in a tumor microenvironment2022

    • Author(s)
      Nakamura Takashi、Kawakami Kyoko、Nomura Momoka、Sato Yusuke、Hyodo Mamoru、Hatakeyama Hiroto、Hayakawa Yoshihiro、Harashima Hideyoshi
    • Journal Title

      Journal of Controlled Release

      Volume: 345 Pages: 200-213

    • DOI

      10.1016/j.jconrel.2022.03.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03387, KAKENHI-PROJECT-19H01170
  • [Journal Article] Investigation of energy metabolic dynamism in hyperthermia-resistant ovarian and uterine cancer cells under heat stress2021

    • Author(s)
      Kanamori Taisei、Miyazaki Natumi、Aoki Shigeki、Ito Kousei、Hisaka Akihiro、Hatakeyama Hiroto
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 114726-114726

    • DOI

      10.1038/s41598-021-94031-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Journal Article] Pharmaceutics Based Researches of DDS and Antibody Drugs for Cancer Therapy2021

    • Author(s)
      畠山 浩人
    • Journal Title

      Journal of Pharmaceutical Science and Technology, Japan

      Volume: 81 Issue: 1 Pages: 75-80

    • DOI

      10.14843/jpstj.81.75

    • NAID

      130007965646

    • ISSN
      0372-7629, 2188-3149
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Journal Article] 担がんマウスモデルを用いた免疫チェックポイント阻害剤の体内動態研究2020

    • Author(s)
      畠山 浩人
    • Journal Title

      Farumashia

      Volume: 56 Issue: 8 Pages: 760-764

    • DOI

      10.14894/faruawpsj.56.8_760

    • NAID

      130007883706

    • ISSN
      0014-8601, 2189-7026
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Journal Article] 50)Cao Q, Zhou M, Wang W, Shi S, Zhao J, Geng Ku, Huang Q, Wen X, Li F, Hatakeyama H, Xu C, Piwnica-Worms D, Peng W, Zhou D, Sood AK, Li C. Induction of Anti-tumor Immunity in Mice by the Combination of Nanoparticle-Based Photothermolysis and Anti-PD-1 Checkpoint Inhibition2020

    • Author(s)
      Cao Q, Zhou M, Wang W, Shi S, Zhao J, Geng Ku, Huang Q, Wen X, Li F, Hatakeyama H, Xu C, Piwnica-Worms D, Peng W, Zhou D, Sood AK, Li C
    • Journal Title

      Nanomedicine

      Volume: 25 Pages: 102169-102169

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04686
  • [Journal Article] Global Comparison of Changes in the Number of Test-Positive Cases and Deaths by Coronavirus Infection (COVID-19) in the World2020

    • Author(s)
      Hisaka Akihiro、Yoshioka Hideki、Hatakeyama Hiroto、Sato Hiromi、Onouchi Yoshihiro、Anzai Naohiko
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 6 Pages: 1904-1904

    • DOI

      10.3390/jcm9061904

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Journal Article] Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells2020

    • Author(s)
      Tomizawa S, Tamori M, Tanaka A, Utsumi N, Sato H, Hatakeyama H, Hisaka A, Kohama T, Yamagata K, Honda T, Nakamura H, Murayama T
    • Journal Title

      Biochim Biophys Acta Mol Cell Biol Lipids

      Volume: 1865 Issue: 6 Pages: 158675-158675

    • DOI

      10.1016/j.bbalip.2020.158675

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08303, KAKENHI-PROJECT-19H03387
  • [Journal Article] Silencing of VEGFR2 by RGD-Modified Lipid Nanoparticles Enhanced the Efficacy of Anti-PD-1 Antibody by Accelerating Vascular Normalization and Infiltration of T Cells in Tumors2020

    • Author(s)
      Cho Riki、Sakurai Yu、Jones Haleigh Sakura、Akita Hidetaka、Hisaka Akihiro、Hatakeyama Hiroto
    • Journal Title

      Cancers

      Volume: 12 Issue: 12 Pages: 3630-3630

    • DOI

      10.3390/cancers12123630

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20195, KAKENHI-PROJECT-19H03387, KAKENHI-PROJECT-20H00657
  • [Journal Article] Induction of Anti-tumor Immunity in Mice by the Combination of Nanoparticle-Based Photothermolysis and Anti-PD-1 Checkpoint Inhibition2020

    • Author(s)
      Cao Q, Zhou M, Wang W, Shi S, Zhao J, Geng Ku, Huang Q, Wen X, Li F, Hatakeyama H, Xu C, Piwnica-Worms D, Peng W, Zhou D, Sood AK, Li C
    • Journal Title

      Nanomedicine

      Volume: 25 Pages: 102169-102169

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Journal Article] Poor outcome with anti-programmed death-ligand 1 (PD-L1) antibody due to poor pharmacokinetic properties in PD-1/PD-L1 blockade-sensitive mouse models2020

    • Author(s)
      Kurino T, Matsuda R, Terui A, Suzuki H, Kokubo T, Uehara T, Arano Y, Hisaka A, Hatakeyama H
    • Journal Title

      J Immunother Cancer

      Volume: 8(1) Issue: 1 Pages: e000400-e000400

    • DOI

      10.1136/jitc-2019-000400

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Journal Article] Development of a Novel Hyperthermia Cancer Therapy by Targeting a Regulator of Hyperthermia Sensitivity2019

    • Author(s)
      畠山 浩人
    • Journal Title

      Journal of Pharmaceutical Science and Technology, Japan

      Volume: 79 Issue: 2 Pages: 80-83

    • DOI

      10.14843/jpstj.79.80

    • NAID

      130007606125

    • ISSN
      0372-7629, 2188-3149
    • Language
      Japanese
    • Open Access
    • Data Source
      KAKENHI-PUBLICLY-18H04686
  • [Journal Article] Model-based meta-analysis to evaluate optimal doses of direct oral factor Xa inhibitors in atrial fibrillation patients2018

    • Author(s)
      Yoshioka H, Sato H, Hatakeyama H, Hisaka H
    • Journal Title

      Blood Advances

      Volume: 2(10) Issue: 10 Pages: 1066-1075

    • DOI

      10.1182/bloodadvances.2017013805

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08436
  • [Journal Article] Investigation of Metabolomic Changes in Sunitinib-Resistant Human Renal Carcinoma 786-O Cells by Capillary Electrophoresis-Time of Flight Mass Spectrometry2018

    • Author(s)
      Hatakeyama H, Fujiwara T, Sato H, Terui A, Hisaka A.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 4 Pages: 619-627

    • DOI

      10.1248/bpb.b17-00992

    • NAID

      130006602497

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H06671
  • [Journal Article] In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus2014

    • Author(s)
      Watanabe T, Hatakeyama H, Matsuda-Yasui C, Sato Y, Sudoh M, Takagi A, Hirata Y, Ohtsuki T, Arai M, Inoue K, Harashima H, Kohara M
    • Journal Title

      Scientific Reports

      Volume: in press Issue: 1 Pages: 4750-4750

    • DOI

      10.1038/srep04750

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-24390117, KAKENHI-PROJECT-24590988, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25860305, KAKENHI-PROJECT-26893001
  • [Journal Article] The systemic administration of an anti-miRNA oligonucleotide encapsulaed pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice2014

    • Author(s)
      Hiroto Hatakeyama, Manami Murata, Yusuke Sato, Mayumi Takahashi, Noriyuki Minakawa, Akira Matsuda, Hideyoshi Harashima
    • Journal Title

      J. Control. Release

      Volume: 173 Pages: 43-50

    • DOI

      10.1016/j.jconrel.2013.10.023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-23249008, KAKENHI-PUBLICLY-24107502, KAKENHI-PUBLICLY-24107518
  • [Journal Article] Improvement of doxorubicin effect using liposomal anti-polo like kinase 1 siRNA in human renal cell carcinomas2014

    • Author(s)
      Sakurai Y, Hatakeyama H, Akita H, Harashima H.
    • Journal Title

      Molecular Pharmaceutics

      Volume: in press Issue: 8 Pages: 2713-2719

    • DOI

      10.1021/mp500245z

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-25893001
  • [Journal Article] Hepatic Monoacylglycerol 0-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes2014

    • Author(s)
      Yasuhiro Hayashi, Erina Suemitsu, Kazuaki Kajimoto, Yusuke Sato, Afsana Akhter, Yu Sakurai, Hiroto Hatakeyama, Mamoru Hyodo, Noritada Kaji, Yoshinobu Baba, Hideyoshi Harashima
    • Journal Title

      Mol. Ther. Nucleic Acids

      Volume: 3 Pages: e154-e154

    • DOI

      10.1038/mtna.2014.4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502
  • [Journal Article] RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system2014

    • Author(s)
      Yu Sakurai, Hiroto Hatakeyama, Yusuke Sato, Mamoru Hyodo, Hidetaka Akita, Noritaka Ohga, Kyoko Hida, Hideyoshi Harashima
    • Journal Title

      J. Control. Release

      Volume: 173 Pages: 110-118

    • DOI

      10.1016/j.jconrel.2013.10.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-25462909, KAKENHI-PROJECT-25893001, KAKENHI-PROJECT-26830101
  • [Journal Article] The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors2013

    • Author(s)
      Hatakeyama H, Akita H, Harashima H
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 36 Issue: 6 Pages: 892-899

    • DOI

      10.1248/bpb.b13-00059

    • NAID

      130003361446

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Journal Article] In vitro potimization of 2'-Ome-4'-thioribonucleoside-modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle2013

    • Author(s)
      Mayumi Takahashi, Naoki Yamada, Hiroto Hatakeyama, Manami Murata, Yusuke Sato, Noriaki Minakawa, Hideyoshi Harashima, Akira Matsuda
    • Journal Title

      Nucleic Acids Res.

      Volume: 41 Issue: 22 Pages: 10659-10667

    • DOI

      10.1093/nar/gkt823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PUBLICLY-24107502, KAKENHI-PUBLICLY-24107518, KAKENHI-PROJECT-24390027
  • [Journal Article] A neutral envelope-type nanoparticle containing pH-responsive and SS-cleavable lipid like material as a carrier for plasmid DNA2013

    • Author(s)
      秋田英万
    • Journal Title

      Adv. Healthc. Mater.

      Volume: (in press) Issue: 8 Pages: 1120-1125

    • DOI

      10.1002/adhm.201200431

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PUBLICLY-24107502
  • [Journal Article] Gene Silencing via RNAi and siRNA quantification in Tumor Tissue using MEND, a Liposomal siRNA Delivery System2013

    • Author(s)
      Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H, Harashima H
    • Journal Title

      Molecular Therapy

      Volume: (印刷中) Issue: 6 Pages: 1195-203

    • DOI

      10.1038/mt.2013.57

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J02352, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502
  • [Journal Article] Development of an Efficient Short Interference RNA (siRNA) Delivery System with a New pH-Sensitive Cationic Lipid2012

    • Author(s)
      佐藤悠介
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 132 Issue: 12 Pages: 1355-1363

    • DOI

      10.1248/yakushi.12-00234-2

    • NAID

      130002489531

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2012-12-01
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-24350087, KAKENHI-PUBLICLY-24107502
  • [Journal Article] A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in VIVO2012

    • Author(s)
      2. Sato Y, Hatakeyama H, Sakurai Y Hyodo M, Akita H, Harashima H
    • Journal Title

      Journal of Controlled Release

      Volume: 163 Issue: 3 Pages: 267-276

    • DOI

      10.1016/j.jconrel.2012.09.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J02352, KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-23700552, KAKENHI-PROJECT-24350087, KAKENHI-PUBLICLY-24107502
  • [Journal Article] A Multifunctional Envelope-type Nanodevice for Use in Nanomedicine: Concept and Applications2012

    • Author(s)
      Nakamura T, Akita H, Yamada Y, Hatakeyama H, Harashima H
    • Journal Title

      Acc Chem Res

      Volume: 45(7) Issue: 7 Pages: 1113-1121

    • DOI

      10.1021/ar200254s

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PUBLICLY-24107502
  • [Journal Article] Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid2011

    • Author(s)
      Hatakeyama H
    • Journal Title

      Biomaterials

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Journal Article] Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid2011

    • Author(s)
      Hatakeyama H, Akita H, Ito E, Hayashi Y, Oishi M, Nagasaki Y, Danev R, Nagayama K, Kaji N, Kikuchi H, Baba Y, Harashima H
    • Journal Title

      Biomaterials

      Volume: 32 Issue: 8 Pages: 4306-4316

    • DOI

      10.1038/mt.2011.24

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Journal Article] A multifunctional envelope type nano device(MEND) for drug and gene delivery to tumors based on the EPR effect : a strategy for overcoming the PEG dilemma2011

    • Author(s)
      Hatakeyama H, Akita H, Harashima H
    • Journal Title

      Adv. Drug Deliv. Rev.

      Volume: 63 Issue: 3 Pages: 152-160

    • DOI

      10.1016/j.addr.2010.09.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Journal Article] A multifunctional envelope type nano device (MEND) for drug and gene delivery to tumors based on the EPR effect : a strategy for overcoming the PEG dilemma2011

    • Author(s)
      Hatakeyama H
    • Journal Title

      Advanced Drug Delivery Review

      Volume: 63 Pages: 152-160

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Journal Article] Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA2011

    • Author(s)
      櫻井遊
    • Journal Title

      Biomaterials

      Volume: 32 Issue: 24 Pages: 5733-5742

    • DOI

      10.1016/j.biomaterials.2011.04.047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J02352, KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-22790143
  • [Journal Article] siRNAキャリアーとしてのリポソームの現状と将来2011

    • Author(s)
      楠本憲司、畠山浩人、原島秀吉
    • Journal Title

      ファルマシア

      Volume: 47(8) Pages: 719-723

    • NAID

      110009884963

    • Data Source
      KAKENHI-PROJECT-22790143
  • [Journal Article] A Novel Nonviral Gene Delivery System : Multifunctional Envelope-Type Nano Device2010

    • Author(s)
      Hatakeyama H, Akita H, Kogure K, Harashima H.
    • Journal Title

      Adv. Biochem. Eng. Biotechnol.

      Volume: 119 Pages: 197-230

    • DOI

      10.1007/10_2008_40

    • ISBN
      9783642149467, 9783642149474
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Journal Article] Ornithine and tryptophan analogs as efficient polycations for siRNA delivery to tumor cells.2010

    • Author(s)
      Y.Sato, H.Hatakeyama, et al.
    • Journal Title

      Biol.Pharm.Bull. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Journal Article] Ornithine and tryptophan analogs as efficient polycations for siRNA delivery to tumor cells2010

    • Author(s)
      Sato Y, Hatakeyama H, Harashima H
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 33(7) Pages: 1246-1249

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Journal Article] siRNA delivery by multifunctional envelope-type nano device (MEND)2010

    • Author(s)
      秋田英万、畠山浩人、原島秀吉
    • Journal Title

      Drug Delivery System

      Volume: 25 Issue: 6 Pages: 590-597

    • DOI

      10.2745/dds.25.590

    • NAID

      10027642874

    • ISSN
      0913-5006, 1881-2732
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Journal Article] pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009

    • Author(s)
      H.Hatakeyama, et al.
    • Journal Title

      J.Control.Release 139

      Pages: 127-132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Journal Article] Harashima. A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009

    • Author(s)
      H. Hatakeyama, E. Ito, H. Akita, M. Oishi, Y. Nagasaki, S. Futaki, H
    • Journal Title

      J. Control. Release 139

      Pages: 127-132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo2009

    • Author(s)
      Hatakeyama H, et al.
    • Journal Title

      J.Cont.Rel. 139(2)

      Pages: 127-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Efficient siRNA delivery to tumor cells using the combination of octaarginine, GALA and tumor-specific, cleavable PEG system.2009

    • Author(s)
      Y.Sakurai, H.Hatakeyama, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
    • Journal Title

      Biol.Pharm.Bull. 32

      Pages: 928-932

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Oishi, Y. Nagasaki, S. Futaki, H. Harashima. Efficient siRNA delivery to tumor cells using the combination of octaarginine, GALA and tumor-specific, cleavable PEG system2009

    • Author(s)
      Y. Sakurai, H. Hatakeyama, H. Akita, M
    • Journal Title

      Biol. Pharm. Bull. 32

      Pages: 928-932

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Journal Article] Efficient siRNA delivery to tumor cells using the combination of octaarginine, GALA and tumor-specific, cleavable PEG system.2009

    • Author(s)
      Y.Sakurai, H.Hatakeyama, et al.
    • Journal Title

      Biol.Pharm.Bull. 32

      Pages: 127-132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009

    • Author(s)
      H.Hatakeyama, E.Ito, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
    • Journal Title

      J.Control.Release 139

      Pages: 127-132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] 多機能性エンベロープナノ構造体の開発-血管をキーワードとして2008

    • Author(s)
      畠山浩人, Diky Mudhakir, 秋田英万, 原島秀吉.
    • Journal Title

      血管医学(メディカルレビュー社) 9(2)

      Pages: 181-187

    • Data Source
      KAKENHI-PROJECT-20890003
  • [Journal Article] 多機能性エンベロープ型ナノ構造体による人工遺伝子デリバリーシステムの創製2008

    • Author(s)
      畠山浩人, 秋田英万, 小暮健太朗, 原島秀吉
    • Journal Title

      化学工業(化学工業社) 59(4)

      Pages: 263-268

    • Data Source
      KAKENHI-PROJECT-20890003
  • [Journal Article] Ornithine and tryptophan analogs as efficient polycations for siRNA delivery to tumor cells.

    • Author(s)
      Y. Sato, H. Hatakeyama, H. Harashima.
    • Journal Title

      Biol. Pharm. Bull. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Patent] 脂質膜構造体にpH依存性カチオン性を付与する剤、それによりpH依存性カチオン性が付与された脂質膜構造体および脂質膜構造体の製造方法2012

    • Inventor(s)
      原島秀吉、畠山浩人、佐藤悠介、兵藤守、櫻井遊、秋田英万
    • Industrial Property Rights Holder
      バイメッドコア
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-011952
    • Filing Date
      2012-05-25
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Patent] 細胞内動態を改善したカチオン性脂質2012

    • Inventor(s)
      丹下耕太、新井将也、久保和弘、秋田英万、原島秀吉、畠山浩人、他
    • Industrial Property Rights Holder
      日油株式会社、北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-11-09
    • Overseas
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Patent] 機能性ポリペプチド及び当該ポリペプチドで修飾された脂質膜構造体2010

    • Inventor(s)
      原島秀吉, 秋田英万, 畠山浩人, 他
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Number
      2010-039667
    • Filing Date
      2010-02-25
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Patent] 機能性ポリペプチドお呼び当該ポリペプチドで就職された脂質膜構造体2010

    • Inventor(s)
      原島秀吉, 秋田英万、榎戸薫、畠山浩人、桜井遊
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2010-02-25
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Patent] 機能性ポリペプチド及び当該ポリペプチドで修飾された脂質膜構造体2010

    • Inventor(s)
      原島秀吉, 秋田英万, 畠山浩人, 他
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Industrial Property Number
      2010-039667
    • Filing Date
      2010-02-25
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Patent] 腫瘍組織で選択的に分解性を示す血中滞留性素子2008

    • Inventor(s)
      原島秀吉, 畠山浩人, など
    • Industrial Property Rights Holder
      北海道大学, 塩野義製薬(株)
    • Filing Date
      2008-12-12
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Patent] の別:国内名称:腫瘍組織で選択的に分解性を示す血中滞留性素子2008

    • Inventor(s)
      秋田英万, 畠山浩人, 原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Filing Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Patent] 腫瘍組織で選択的に分解性を示す血中滞留性素子2008

    • Inventor(s)
      秋田英万, 畠山浩人, 原島秀吉
    • Industrial Property Rights Holder
      国立大学法人北海道大学
    • Filing Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Presentation] 腹膜播種への効率的な薬物送達を実現する古くて新しい腹腔内投与2024

    • Author(s)
      畠山浩人
    • Organizer
      日本薬学会第144年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] Re-thinking of delivery strategy of biologics and nano DDSto tumor: beyond the EPR effect2023

    • Author(s)
      Hiroto Hatakeyama
    • Organizer
      2023 ICCP/JSSX International Joint Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] Investigation of delivery of immune checkpoint inhibitors after i.p. administration to peritoneal metastasis via direct penetration: Effect on differences in primary lesion2023

    • Author(s)
      Ryota Tsuda, Mayu Yamamoto, Yui Matsumoto, Chongjie Zhang, Yuta Tamemoto, Hiroto Hatakeyama
    • Organizer
      2023 ICCP/JSSX International Joint Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] Elucidation of pharmacokinetic factors affecting the efficacy of immune checkpoint inhibitors.2023

    • Author(s)
      Hiroto Hatakeyama
    • Organizer
      Canadian Society of Pharmaceutical Sciences (CSPS) Annual Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] Elucidation of pharmacokinetic factors affecting the efficacy of immune checkpoint inhibitors.2023

    • Author(s)
      Hiroto Hatakeyama
    • Organizer
      Faculty of Pharmacy and Pharmaceutical Sciences Seminar Series, the University of Alberta
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] 腹腔内投与した抗PD-L1抗体の組織内分布に関するがん種特異性の検討2023

    • Author(s)
      津田涼太、山本麻由、松本唯、張崇傑、畠山浩人
    • Organizer
      第39回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] 抗体・ナノDDSのEPR効果に基づく腫瘍送達戦略について考える2023

    • Author(s)
      畠山浩人
    • Organizer
      第21回遺伝子・デリバリー研究会夏期セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] 免疫チェックポイント阻害剤の腹膜播種への効率的な送達に適切な投与経路とは?2023

    • Author(s)
      畠山浩人
    • Organizer
      第32回日本がん転移学会学術集会・総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] EPR効果に基づく高分子医薬・DDSの腫瘍送達戦略を考える2023

    • Author(s)
      畠山浩人
    • Organizer
      徳島大学研究クラスター「次世代DDS拠点形成」・iTEX合同シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] Elucidation of pharmacokinetic factors affecting the efficacy of immune checkpoint inhibitors2023

    • Author(s)
      Hiroto Hatakeyama
    • Organizer
      JSP/CSPS Joint Symposium, the 143rd Annual Meeting of the Pharmaceutical Society of Japan
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] Tumor-associated neutrophils and macrophages exacerbate anti-drug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor.2023

    • Author(s)
      Ruiheng Tag, Takahiro Arai, Tomomi Kokubo, Hirohito Abo, Hiroto Kawashima, Akihiro Hisaka, Hiroto Hatakeyama
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PUBLICLY-21H05506
  • [Presentation] 免疫チェックポイント阻害剤の腹膜播種への効率的な投与経路を探る―動態研究の立場から2023

    • Author(s)
      畠山浩人
    • Organizer
      第4回腹膜播種研究会シンポジウム・第61回日本癌治療学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] xploring of pharmacokinetic factors affecting the efficacy and adverse events of immune checkpoint inhibitors.2023

    • Author(s)
      Hiroto Hatakeyama
    • Organizer
      2023 ICCP/JSSX International Joint Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] 免疫チェックポイント阻害剤の腹腔内投与による腹腔内腫瘍移行メカニズムの解明2022

    • Author(s)
      山本麻由、松田怜子、栗野泰大、ジョーンズヘイリーさくら、中村快人、辻厚至、須堯綾、松本唯、櫻井遊、鈴木博元、秋田英万、上原知也、樋坂章博、畠山浩人
    • Organizer
      日本薬剤学会第37年会
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] 免疫チェックポイント阻害剤の体内動態が薬効や副作用に及ぼす影響~マウスモデルの解析から見えてくるもの2022

    • Author(s)
      畠山浩人
    • Organizer
      第17回iMeC-WISEセミナー
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-21H05506
  • [Presentation] 腹腔内投与した腹腔内投与した免疫チェックポイント阻害剤の腹腔内腫瘍移行メカニズムの解明および腹膜播種治療効果の検証2022

    • Author(s)
      山本麻由、ジョーンズヘイリーさくら、中村快人、辻厚至、須堯綾、鈴木博元、秋田英万、上原知也、樋坂章博、畠山浩人
    • Organizer
      第38回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] がん病態が増悪する免疫チェックポイント阻害剤に対するアナフィラキシー:マウスモデルの解析から2022

    • Author(s)
      畠山浩人
    • Organizer
      第96回日本薬理学会/第43回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PUBLICLY-21H05506
  • [Presentation] Delivery of an immune checkpoint inhibitor to i.p. tumors via direct penetration by i.p. route: beyond the EPR effect2022

    • Author(s)
      Hatakeyama H, Yamamoto M, Kurino T, Matsuda R, Tsuji A, Suzuki H, Uehara T, Akita H, Hisaka A
    • Organizer
      第37回日本薬物動態学会
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] がん病態が増悪する免疫チェックポイント阻害剤に対するアナフィラキシー:マウスモデルの解析から2022

    • Author(s)
      畠山浩人
    • Organizer
      第29回日本免疫毒性学会学術年会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-21H05506
  • [Presentation] がん病態で増加する骨髄系細胞は抗PD-L1抗体に対するアナフィラキシーを増悪する2022

    • Author(s)
      荒井貴宏、小久保朋美、唐鋭恒、安保博仁、平川城太朗、秋田英万、川島博人、樋坂章博、畠山浩人
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PUBLICLY-21H05506
  • [Presentation] 担癌モデルを用いた免疫チェックポイント阻害剤の薬効に及ぼす体内動態要因の解析2022

    • Author(s)
      畠山浩人
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2022
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] 腹腔内投与した免疫チェックポイント阻害剤の腹腔内腫瘍に対する移行メカニズムの検討2022

    • Author(s)
      山本麻由、松田怜子、栗野泰大、松本唯、鈴木博元、櫻井遊、秋田英万、上原知也、樋坂章博、畠山浩人
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 免疫チェックポイント阻害剤の体内動態が薬効や副作用に及ぼす影響~マウスモデルの解析から見えてくるもの2022

    • Author(s)
      畠山浩人
    • Organizer
      第17回iMeC-WISEセミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] 腹腔内投与した免疫チェックポイント阻害剤の腹腔内腫瘍移行メカニズムの解明2022

    • Author(s)
      山本麻由、松田怜子、栗野泰大、ジョーンズヘイリーさくら、中村快人、辻厚至、須堯綾、松本唯、櫻井遊、鈴木博元、秋田英万、上原知也、樋坂章博、畠山浩人
    • Organizer
      第27回創剤フォーラム若手研究会
    • Data Source
      KAKENHI-PROJECT-23K24041
  • [Presentation] 免疫チェックポイント阻害剤の薬効に影響する動態要因の解析 ~マウスモデルから見えてくるもの2021

    • Author(s)
      畠山浩人
    • Organizer
      薬物動態談話会2021年1月例会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] マウスモデルを用いた抗CTLA4抗体に対する耐性メカニズムの検討2021

    • Author(s)
      ジョーンズヘイリーさくら、栗野泰大、照井亜侑、鈴木博元、上原知也、樋坂章博、畠山浩人
    • Organizer
      第65回日本薬学会関東支部会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 脂質ナノ粒子の腹腔内腫瘍への移行に影響する投与経路の検討2021

    • Author(s)
      松本唯、張俐綺、五味昌樹、櫻井遊、松田怜子、秋田英万、樋坂章博、畠山浩人
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 温熱耐性がん細胞の発見と新たながん温熱治療の開発へ2021

    • Author(s)
      畠山浩人
    • Organizer
      日本薬学会第46回学術講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] Comparison of anti-CTLA-4 antibody therapy-sensitive and resistant murine models to elucidate causes of difference in response2021

    • Author(s)
      Jones HS, Kurino T, Terui A, Matsuda R, Suzuki H, Uehara T, Hisaka A, Hatakeyama H
    • Organizer
      日本薬物動態学会第36回年会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 温熱耐性を有するがん細胞のエネルギー代謝の解析2021

    • Author(s)
      金森大誠、宮崎菜摘、青木重樹、伊藤晃成、樋坂章博、畠山浩人
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 腹腔内投与による免疫チェックポイント阻害剤の腹腔内腫瘍への選択的送達と治療への応用2021

    • Author(s)
      畠山浩人
    • Organizer
      日本薬学会第141年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] Anti-PD-L1 antiobdy shows less efficacy than anti-PD-1 antibody due to poor PK properties in mice models2021

    • Author(s)
      Hatakeyama H, Kurino T, Matsuda R, Terui A, Suzuki H, Kokubo T, Uehara T, Arano Y, Hisaka A
    • Organizer
      24th North American ISSX Meeting
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 熱ストレス下における熱耐性卵巣癌細胞の代謝シフトの解明2021

    • Author(s)
      金森大誠、宮崎菜摘、青木重樹、伊藤晃成、樋坂章博、畠山浩人
    • Organizer
      第65回日本薬学会関東支部会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 投与経路による脂質ナノ粒子の腹腔内腫瘍に対する送達の違い2021

    • Author(s)
      松本唯、張俐綺、五味昌樹、櫻井遊、田中浩揮、松田怜子、秋田英万、樋坂章博、畠山浩人
    • Organizer
      第37回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 温熱耐性を有するがん細胞のエネルギー代謝の解析2021

    • Author(s)
      金森大誠、宮崎菜摘、青木重樹、伊藤晃成、樋坂章博、畠山浩人
    • Organizer
      日本薬剤学会第36年会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 脂質ナノ粒子の腹腔内投与による腹腔内腫瘍への送達に関する検討2021

    • Author(s)
      松本唯、張俐綺、五味昌樹、櫻井遊、松田怜子、秋田英万、樋坂章博、畠山浩人
    • Organizer
      日本薬剤学会第36年会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] がん病態で増加する骨髄系細胞は抗PD-L1抗体に対するアナフィラキシーを増悪する2021

    • Author(s)
      荒井貴宏、小久保朋美、唐鋭恒、安保博仁、平川城太朗、秋田英万、川島博人、樋坂章博、畠山浩人
    • Organizer
      第65回日本薬学会関東支部会
    • Data Source
      KAKENHI-PUBLICLY-21H05506
  • [Presentation] Comparison of anti-CTLA-4 antibody therapy-sensitive and resistant murine models to elucidate causes of difference in response2021

    • Author(s)
      Jones HS, Kurino T, Terui A, Matsuda R, Suzuki H, Uehara T, Hisaka A, Hatakeyama H
    • Organizer
      24th North American ISSX Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 免疫チェックポイント阻害剤の薬効に影響する動態要因の解析 ~マウスモデルから見えてくるもの2021

    • Author(s)
      畠山浩人
    • Organizer
      日本薬物動態学会第36回年会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-21H05506
  • [Presentation] 薬剤学を基盤としたDDS・抗体医薬のがん治療に関する研究2020

    • Author(s)
      畠山浩人
    • Organizer
      日本薬剤学会第35年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] がんが温熱療法に耐性を有する機構のトランスオミクス解析による解明2020

    • Author(s)
      金森大誠、樋坂章博、畠山浩人
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PUBLICLY-18H04686
  • [Presentation] がんが温熱療法に耐性を有する機構のトランスオミクス解析による解明2020

    • Author(s)
      金森大誠、堀川夕維、樋坂章博、畠山浩人
    • Organizer
      日本薬剤学会第35年会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 腹腔内投与による免疫チェックポイント阻害剤の腹腔内腫瘍への選択的送達と治療戦略2020

    • Author(s)
      畠山浩人
    • Organizer
      第36回日本DDS学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] Comparative analysis between anti-PD-1 and anti-PD-L1 antibody in mouse models- Is anti-PD-L1 antibody equivalent to anti-PD-1 antibody in terms of pharmacokinetics and efficacy?2020

    • Author(s)
      Hatakeyama H
    • Organizer
      iPoPS2020
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 免疫チェックポイント阻害剤の薬効に影響する動態要因の解明と難治性がん治療への応用2020

    • Author(s)
      畠山浩人、樋坂章博
    • Organizer
      日本薬学会第140年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] マウス担癌モデルにおける抗CTLA4抗体の作用機序の検討2020

    • Author(s)
      101)ジョーンズ ヘイリーさくら、栗野泰大、照井亜侑、松田怜子、鈴木博元、上原知也、樋坂章博、畠山浩人
    • Organizer
      日本薬剤学会第35年会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 金ナノロッドを用いた局所温熱療法の併用による抗PD-1抗体の抗腫瘍効の検討2019

    • Author(s)
      堀川夕維、畠山浩人、新留琢朗、秋田英万、樋坂章博
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2019
    • Data Source
      KAKENHI-PUBLICLY-18H04686
  • [Presentation] 膵癌発症マウスを用いた 腹腔内及び静脈内投与後の抗PD-L1抗体の組織移行性の比較解析2019

    • Author(s)
      松田怜子、栗野泰大、佐野誠、櫻井遊、鈴木博元、上原知也、秋田英万、伊地知秀明、荒野泰、畠山浩人、樋坂章博
    • Organizer
      第13回次世代を担う若手医療薬科学シンポジウム
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] Poor outcome with anti-PD-L1 antibody due to undesirable pharmacokinetic properties in PD-1/PD-L1 blockade sensitive mouse models2019

    • Author(s)
      Hatakeyama H, Kurino T, Matsuda R, Suzuki H, Terui A, Uehara T, Arano Y, Hisaka A
    • Organizer
      Fifth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] Pharmacokinetic analysis of anti-PD-1 and PD-L1 antibodies and evaluation of their anti-tumor effects2019

    • Author(s)
      Hatakeyama H, Kurino T, Matsuda R, Suzuki H, Terui A, Uehara T, Arano Y, Hisaka A.
    • Organizer
      AACR Annual Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 免疫チェックポイント阻害剤におけるモデルの分類と薬効に影響する因子の探索2019

    • Author(s)
      照井亜侑、畠山浩人、樋坂章博
    • Organizer
      医療薬学フォーラム2019/第27回クリニカルファーマシーシンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 金ナノロッドを用いた局所温熱療法の併用による抗PD-1抗体の抗腫瘍効の検討2019

    • Author(s)
      堀川夕維、畠山浩人、新留琢朗、秋田英万、樋坂章博
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2019
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 母集団薬物動態解析における 機械学習の有用性評価:非線形混合効果モデル(NONMEM)との比較2019

    • Author(s)
      吉岡英樹, 佐藤洋美, 畠山浩人, 樋坂章博
    • Organizer
      第40回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08436
  • [Presentation] CTGF Knockdown Sensitizes Hyperthermia Therapy by NIR and CuS Nanoparticles in Orthotopic Models of Ovarian Cancers2019

    • Author(s)
      Hatakeyama H
    • Organizer
      Liposome Research Days 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04686
  • [Presentation] 動態解析に基づく抗PD-1/PD-L1抗体の比較検討2019

    • Author(s)
      栗野泰大、畠山浩人、松田怜子、鈴木博元、小久保朋美、照井亜侑、上原知也、荒野泰、樋坂章博
    • Organizer
      第23回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 抗PD-1/PD-L1抗体の薬効と体内動態の関連に関する検討2019

    • Author(s)
      畠山浩人、栗野泰大、松田怜子、鈴木博元、小久保朋美、照井亜侑、上原知也、荒野泰、樋坂章博
    • Organizer
      第35回日本DDS学会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 抗PD-1抗体と抗PD-L1抗体は同等か―マウスモデルを用いた動態と薬効の比較解析2019

    • Author(s)
      畠山浩人、栗野泰大、松田怜子、鈴木博元、小久保朋美、照井亜侑、上原知也、荒野泰、樋坂章博
    • Organizer
      医療薬学フォーラム2019/第27回クリニカルファーマシーシンポジウム
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 抗PD-1/PD-L1抗体の体内動態の違いが薬効に及ぼす影響2019

    • Author(s)
      畠山浩人、栗野泰大、松田怜子、鈴木博元、小久保朋美、照井亜侑、上原知也、荒野泰、樋坂章博
    • Organizer
      日本薬剤学会第34年会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] Anti-PD-1 Antibodies is Advantageous Compared to Anti-PD-L1 Antibodies in Terms of PK2019

    • Author(s)
      Kurino T, Hatakeyama H, Matsuda R, Suzuki H, Kokubo T, Terui A, Uehara T, Arano Y, Hisaka A
    • Organizer
      第13回次世代を担う若手医療薬科学シンポジウム
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 膵癌発症マウスを用いた腹腔内及び静脈内投与後の抗PD-L1抗体の組織移行性の比較解析2019

    • Author(s)
      松田怜子、栗野泰大、佐野誠、櫻井遊、鈴木博元、上原知也、秋田英万、伊地知秀明、荒野泰、畠山浩人、樋坂章博
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2019
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 抗PD-1抗体の動態特性は抗PD-L1抗体に比べ優れている2019

    • Author(s)
      栗野大泰、畠山浩人、松田怜子、鈴木博元、小久保朋美、照井亜侑、上原知也、荒野泰、樋坂章博
    • Organizer
      日本薬物動態学会第34回年会
    • Data Source
      KAKENHI-PROJECT-19H03387
  • [Presentation] 温熱耐性卵巣がんの発見と温熱耐性制御分子CTGFの解析2018

    • Author(s)
      畠山浩人、スード アニル
    • Organizer
      第 12 回 次世代を担う若手医療薬科学シンポジウム
    • Data Source
      KAKENHI-PUBLICLY-18H04686
  • [Presentation] TGF Knockdown Sensitizes Hyperthermia Therapy by NIR and CuS Nanoparticles in Orthotopic Models of Ovarian Cancers2018

    • Author(s)
      Hatakeyama H
    • Organizer
      The 2nd Workshop for Korea-Japan Young Scientists on Pharmaceutics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04686
  • [Presentation] 担癌マウスにおける免疫チェックポイント阻害剤の組織内分布の解析とそれらが薬効特性に及ぼす影響2018

    • Author(s)
      栗野泰大、畠山浩人、鈴木博元、小久保朋美、照井亜侑、荒野泰、樋坂章博
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16H06671
  • [Presentation] CTGF Knockdown Sensitizes Hyperthermia Therapy by NIR and CuS Nanopraticles in Orthotopic Ovarian Cancers2018

    • Author(s)
      Hatakeyama H
    • Organizer
      1st International Symposium of Soft Molecular Activation Research Center (SMARC)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04686
  • [Presentation] モデル基盤メタ・アナリシスに基づく第Xa因子阻害剤の至適用量の推定2017

    • Author(s)
      吉岡英樹、畠山浩人、佐藤洋美、樋坂章博
    • Organizer
      第39回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08436
  • [Presentation] Prediction of efficacy of immune checkpoint inhibitors using an immune checkpoints gene signature in non-clinical sensitive and resistant models2017

    • Author(s)
      Hatakeyama H, Terui A, Hisaka A
    • Organizer
      Third CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06671
  • [Presentation] 免疫チェックポイント阻害剤感受性/耐性モデルにおけるPD-L1発現量の相関性に関する検討2017

    • Author(s)
      照井亜侑、畠山浩人、樋坂章博
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      宮城、仙台国際センター
    • Year and Date
      2017-03-26
    • Data Source
      KAKENHI-PROJECT-16H06671
  • [Presentation] 抗PD-1抗体感受性・耐性マウスモデルの探索と感受性に影響を及ぼす因子の解析2017

    • Author(s)
      畠山浩人、照井亜侑、樋坂章博
    • Organizer
      第21回日本がん免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H06671
  • [Presentation] 腫瘍血管内皮細胞へのin vivo siRNA導入法の確立2013

    • Author(s)
      櫻井遊、畠山浩人、佐藤悠介、兵藤守、秋田英万、大賀則孝、樋田京子、原島秀吉
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      千里阪急ホテル(大阪府)
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] 腫瘍血管内皮細胞を標的としたsiRNAデリバリーとがん治療2013

    • Author(s)
      櫻井遊、畠山浩人、秋田英万、原島秀吉
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      ウインクあいち(愛知県)
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] 腫瘍血管内皮細胞へのアクティブターゲティング型siRNAデリバリーシステム2013

    • Author(s)
      櫻井遊、畠山浩人、秋田英万、大賀則孝、樋田京子、原島秀吉
    • Organizer
      第23回アンチセンスシンポジウム
    • Place of Presentation
      大塚講堂(徳島県)
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] 腫瘍血管内皮細胞を標的としたsiRNA送達とがん治療への応用2013

    • Author(s)
      畠山浩人、櫻井遊、秋田英万、原島秀吉
    • Organizer
      第29回日本DDS学会学術集会
    • Place of Presentation
      京都テルサ(京都府)
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] 肝臓miRNA制御を目的とした全身投与型デリバリーシステムの開発2013

    • Author(s)
      畠山浩人、村田真那美、佐藤悠介、原島秀吉
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      ウインクあいち(愛知県)
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] Development of an in vivo Active siRNA Delivery System to Tumor Endothelial Cells using Cyclic RGD-modified Liposomal siRNA2013

    • Author(s)
      Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H, Harashima H
    • Organizer
      9th annual meeting of the Oligonucleotide Therapeutics Society
    • Place of Presentation
      Royal Continetal Hotel (Naples, Italy)
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] Development of a pH-sensitive multifunctional envelope-type nano device (MEND) as an efficient nucleic acids delivery system2013

    • Author(s)
      Hatakeyama H, Sato Y, Sakurai Y, Harashima H
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Hawaii Convention Center (Hawaii, USA)
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] 肝臓を標的とした全身投与型AMOデリバリーシステムの構築2013

    • Author(s)
      村田真那美、畠山浩人、佐藤悠介、高橋真由美、南川典昭、松田彰、原島秀吉
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] siRNA封入pH応答性MENDによるHCV治療2013

    • Author(s)
      佐藤悠介、畠山浩人、渡邊綱正、小原道法、原島秀吉
    • Organizer
      第29回日本DDS学会学術集会
    • Place of Presentation
      京都テルサ(京都府)
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] DNAマイクロアレイとin vivo siRNA送達システムの融合による新規2型糖尿病治療薬創出2013

    • Author(s)
      末光永里奈、林泰弘、梶本和昭、佐藤悠介、Afsana Akhter、櫻井遊、畠山浩人、兵藤守、加地範匡、馬場嘉信、原島秀吉
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      ウインクあいち(愛知県)
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] Development of a systemic anti-miRNA oligonucleotide (AMO) delivery system to liver2013

    • Author(s)
      Murata M, Hatakeyama H, Sato Y, Harashima H
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Hawaii Convention Center (Hawaii, USA)
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] siRNA搭載pH応答性MENDの構築とin vivoへの応用2012

    • Author(s)
      佐藤悠介、畠山浩人、櫻井遊、兵藤守、秋田英万、原島秀吉
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] pH応答性カチオン性脂質を用いた腫瘍組織へのsiRNAでリバリーシステムの構築2012

    • Author(s)
      櫻井遊、畠山浩人、佐藤悠介、兵藤守、秋田英万、原島秀吉
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-06-24
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] An integrated strategy with DNA microarray and non-viral in vivo siRNA delivery to discover novel therapeutic targets for type 2 diabetes.2012

    • Author(s)
      Hayashi Y, Kajimoto K, Sato Y, Suemitsu E, Akhter A, Sakurai Y, Hatakeyama H, Hyodo M, Kaji N, Baba Y, Harashima H
    • Organizer
      10 th Annual Discovery on Target
    • Place of Presentation
      Copley Marriott Hotel (USA)
    • Year and Date
      2012-10-01
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] siRNA搭載pH応答性MENDのin vivoにおける機能評価2012

    • Author(s)
      藤悠介、畠山浩人、兵藤守、秋田英万、原島秀吉
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-06-24
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] siRNA搭載pH応答性MENDの構築とin vivoへの応用2012

    • Author(s)
      佐藤悠介、畠山浩人, 他
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)(招待講演)
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Confirming RNAi-mediated Gene Silencing in tumor by PEGylated siRNA-loaded liposome.2012

    • Author(s)
      Sakurai Y, Sato Y, Hatakeyama H, Akita H, Hyodo M, Harashima H.
    • Organizer
      39th Annual Meeting Exposition of the Controlled Release Society
    • Place of Presentation
      Quebec City Convention Centre (Canada)
    • Year and Date
      2012-07-15
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] 薬物をがん細胞・血管内皮細胞へ送り分けるDDSの開発2012

    • Author(s)
      畠山浩人、原島秀吉
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2012-07-04
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-24107502
  • [Presentation] Endosomal Escape of liposomal siRNA via membrane fusion and in vivo delivery to tumor2011

    • Author(s)
      Sakurai Y, Hatakeyama H, et al
    • Organizer
      7th annual meeting of the Oligonucleotide Therapeutics Society
    • Place of Presentation
      The Black Diamond at The Royal Library Copenhagen (Denmark)
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] In vivo siRNA delivery with pH-sensitive liposome2011

    • Author(s)
      Sato Y, Hatakeyama H, et al
    • Organizer
      7th annual meeting of the Oligonucleotide Therapeutics Society
    • Place of Presentation
      The Black Diamond at The Royal Library Copenhagen (Denmark)
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] 腫瘍選択的siRNAデリバリーシステムの開発2011

    • Author(s)
      畠山浩人, 他
    • Organizer
      薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京)(招待講演)
    • Year and Date
      2011-05-29
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] 腫瘍選択的siRNAデリバリーシステムの開発2011

    • Author(s)
      畠山浩人、秋田英万、原島秀吉
    • Organizer
      薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-05-29
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] 細胞内動態制御に基づくin vivo siRNAデリバリー技術の構築2011

    • Author(s)
      櫻井遊、畠山浩人、秋田英万、原島秀吉
    • Organizer
      薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-05-31
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Endosomal Escape of liposomal siRNA via membrane fusion and in vivo delivery to tumor2011

    • Author(s)
      Sakurai Y, Hatakeyama H, Sato Y, Akita H, Harashima H
    • Organizer
      7th annual meeting of the Oligonucleotide Therapeutics Society
    • Place of Presentation
      The Black Diamond at The Royal Library Copenhagen(Denmark)
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] In vivo siRNA delivery with pH-sensitive liposome2011

    • Author(s)
      Sato Y, Hatakeyama H, Sakurai Y, Hyodo M, Akita H, Harashima H
    • Organizer
      7th annual meeting of the Oligonucleotide Therapeutics Society
    • Place of Presentation
      The Black Diamond at The Royal Library Copenhagen(Denmark)
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] pH応答性膜融合性ペプチドを用いた腫瘍組織へのin vivo siRNAデリバリー技術の構築2011

    • Author(s)
      櫻井遊、畠山浩人、秋田英万、二木史朗、原島秀吉
    • Organizer
      遺伝子デリバリー研究会第11回夏期セミナー
    • Place of Presentation
      三翠園ホテル(高知)
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] pH変化に応答するsiRNA封入MENDの構築2011

    • Author(s)
      佐藤悠介、畠山浩人、秋田英万、兵藤守、原島秀吉
    • Organizer
      薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-05-29
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] 細胞内動態制御に基づくin vivo siRNAデリバリー技術の構築2011

    • Author(s)
      櫻井遊、畠山浩人, 他
    • Organizer
      薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京)(招待講演)
    • Year and Date
      2011-05-31
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] 多機能性エンベロープ型ナノ構造体によるsiRNAの送達制御2010

    • Author(s)
      原島秀吉、秋田英万、畠山浩人
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山国際会議場(富山)
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] siRNA封入MENDのエンドソーム脱出促進とin vivoがんへのデリバリー2010

    • Author(s)
      櫻井遊、畠山浩人、秋田英万、二木史朗、原島秀吉
    • Organizer
      第26回日本DDS学会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2010-06-17
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] 腫瘍を標的とする革新的なin vivo siRNAデリバリーシステムの構築2010

    • Author(s)
      畠山浩人、秋田英万、原島秀吉
    • Organizer
      第26回日本DDS学会
    • Place of Presentation
      大阪、大阪国際交流センター(招待講演)
    • Year and Date
      2010-06-18
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Development of siRNA-containing nanoparticles for in vitro and in vivo gene silencing in tumor by controlling intracellular trafficking2010

    • Author(s)
      Hatakeyama H, et al.
    • Organizer
      12th LIPOSOME RESEARCH DAYS CONFERENCE
    • Place of Presentation
      Marriott Wardman Park Hotel, Washington DC, USA
    • Year and Date
      2010-08-04
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Application of siRNA-containing nanoparticles for in vitro and in vivo gene silencing in tumor by controlling intracellular trafficking2010

    • Author(s)
      Hatakeyama H, et al.
    • Organizer
      The 13th Annual Meeting of the American Society of Gene and Cell Therapy
    • Place of Presentation
      University of British Columbia, Vancouver, Canada.
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] がんへの核酸デリバリーシステムの開発~PEGのジレンマへの挑戦~2010

    • Author(s)
      畠山浩人、秋田英万、原島秀吉
    • Organizer
      薬剤学会第25年会
    • Place of Presentation
      徳島、徳島県郷上文化会館(招待講演)
    • Year and Date
      2010-05-12
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] オルニチン/トリプトファン(Orn/Trp)アナログを用いたがん細胞への効率的なsiRNAデリバリー2010

    • Author(s)
      佐藤悠介、畠山浩人、原島秀吉
    • Organizer
      第26回日本DDS学会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] がんへの核酸デリバリーシステムの開発~PEGのジレンマへの挑戦~2010

    • Author(s)
      畠山浩人、秋田英万、原島秀吉
    • Organizer
      薬剤学会第25年会
    • Place of Presentation
      徳島県郷土文化会館(徳島)
    • Year and Date
      2010-05-12
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Application of siRNA-containing nanoparticles for in vitro and in vivo gene silencing in tumor by controlling intracellular trafficking2010

    • Author(s)
      Hatakeyama H, Ito E, Akita H, Oishi M, Nagasaki Y, Futaki S, Harashima H
    • Organizer
      The 13th Annual Meeting of the American Society of Gene and Cell Therapy
    • Place of Presentation
      Marriott Wardman Park Hotel(USA)
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Application of siRNA-containing nanoparticles for in vitro and in vivo gene silencing in tumor by controlling intracellular trafficking2010

    • Author(s)
      Hatakeyama H, et al.
    • Organizer
      The 13th Annual Meeting of the American Society of Gene and Cell Therapy
    • Place of Presentation
      Marriott Wardman Park Hotel, Washington DC, USA
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] A pH-sensitive fusogenic peptide modified siRNA-encapsulating nanoparticles exerts the gene silencing synergistically with tumor-specific cleavable PEG-lipid2010

    • Author(s)
      Sakurai Y, Hatakeyama H, Akita H, Oishi M, Nagasaki Y, Futaki S, Harashima H
    • Organizer
      The 13th Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      Marriott Wardman Park Hotel(USA)
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Development of systemic siRNA delivery system : manipulation of intracellular trafficking2010

    • Author(s)
      Hatakeyama H
    • Organizer
      13 the JOINT Hokkaido University-Seoul national University SYMPOSIUM
    • Place of Presentation
      Sapporo, Hokkaido University(招待講演)
    • Year and Date
      2010-11-26
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] 腫瘍を標的とする革新的なin vivo siRNAデリバリーシステムの構築2010

    • Author(s)
      畠山浩人、秋田英万、原島秀吉
    • Organizer
      第26回日本DDS学会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2010-06-18
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] 多機能性エンベロープ型ナノ構造体によるsiRNAの送達制御2010

    • Author(s)
      原島秀吉、秋田英万、畠山浩人
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山、富山国際会議場(招待講演)
    • Year and Date
      2010-11-29
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] エンドソーム脱出素子を搭載したsiRNAデリバリーシステムの開発2010

    • Author(s)
      櫻井遊、畠山浩人, 他
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山、富山国際会議場
    • Year and Date
      2010-11-30
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Development of siRNA-containing nanoparticles for in vitro and in vivo gene silencing in tumor by controlling intracellular trafficking2010

    • Author(s)
      Hatakeyama H, Ito E, Akita H, Oishi M, Nagasaki Y, Futaki S, Harashima H
    • Organizer
      12th LIPOSOME RESEARCH DAYS CONFERENCE
    • Place of Presentation
      The University of British Columbia(Canada)
    • Year and Date
      2010-08-04
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Development of Systemic siRNA Delivery System for Tumor with endosomal escape device2010

    • Author(s)
      畠山浩人、秋田英万、原島秀吉
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Development of Systemic siRNA Delivery System for Tumor with endosomal escape device2010

    • Author(s)
      畠山浩人、秋田英万、原島秀吉
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪、大阪国際会議場
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] エンドソーム脱出素子を搭載したsiRNAデリバリーシステムの開発2010

    • Author(s)
      櫻井遊、畠山浩人、秋田英万、二木史朗、原島秀吉
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山国際会議場(富山)
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Development of systemic siRNA delivery system : manipulation of intracellular trafficking2010

    • Author(s)
      Hatakeyama H
    • Organizer
      13 the JOINT Hokkaido University-Seoul national University SYMPOSIUM
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2010-11-26
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] Ornithine and tryptophan as an efficient polycation for siRNA delivery to tumor cells2010

    • Author(s)
      Sato Y, Hatakeyama H, Harashima H
    • Organizer
      The 13th Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      Marriott Wardman Park Hotel(USA)
    • Year and Date
      2010-05-22
    • Data Source
      KAKENHI-PROJECT-22790143
  • [Presentation] 血清耐性MENDを用いたがん選択的siRNAデリバリーシステムの機能評価2009

    • Author(s)
      櫻井遊, 畠山浩人, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都、国立京都国際会館
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] Development of efficient siRNA delivery system to tumor cells by combining octaarginine, GALA and enzymatically-cleavable PEG-lipid.2009

    • Author(s)
      Y. Sakurai, H. Hatakeyama, et al
    • Organizer
      The Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] 血清耐性MENDを用いたがん選択的siRNAデリバリーシステムの機能評価2009

    • Author(s)
      櫻井遊, 畠山浩人, 秋田英万, 大石基, 長崎幸夫, 二木史朗, 原島秀吉
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhanced the gene silencing of siRNA-containing nanoparticles in vitro and in vivo2009

    • Author(s)
      H. Hatakeyama, E. Ito, H. Akita, M. Oishi, Y. Nagasaki, S. Futaki, H. Harashima
    • Organizer
      Joint Symposium of OTS-Antisense 2009
    • Place of Presentation
      Fukuoka, Japan.
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] Development of efficient siRNA delivery system to tumor cells by combining octaarginine, GALA and enzymatically- cleavable PEG-lipid.2009

    • Author(s)
      Y.Sakurai, H.Hatakeyama, et al.
    • Organizer
      The Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Presentation] Development of efficient siRNA delivery system to tumor cells by combining octaarginine, GALA and enzymatically-cleavable PEG-lipid2009

    • Author(s)
      Y.Sakurai, H.Hatakeyama, et al.
    • Organizer
      The Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      Fukuoka, the Centennial Hall Kyushu University.
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhanced the gene silencing of siRNA-containing nanoparticles in vitro and in vivo2009

    • Author(s)
      H.Hatakeyama, et al.
    • Organizer
      Joint Symposium of OTS-Antisense 2009
    • Place of Presentation
      Fukuoka, the Centennial Hall Kyushu University.
    • Year and Date
      2009-11-04
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] 膜融合性ペプチドを用いた腫瘍選択的siRNAデリバリーシステムの開発2009

    • Author(s)
      畠山浩人, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都、国立京都国際会館
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] Systemic siRNA Delivery Using a Maltifunctional Nanodevice with Programmed Tumor Activation.2008

    • Author(s)
      H. Hatakeyama, et al
    • Organizer
      11th LIPOSOME RESEARCH DAYS CONFERENCE
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-07-22
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] 膜融合性ペプチドを用いたsiRNAデリバリーシステムの開発2008

    • Author(s)
      伊東恵里佳, 畠山浩人, 他
    • Organizer
      北海道支部第131回例会
    • Place of Presentation
      北海道、北海道薬科大学
    • Year and Date
      2008-11-29
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] Systemic siRNA Delivery Using a Maltifunctional Nanodevice with Programmed Tumor Activation2008

    • Author(s)
      H. Hatakeyama, et.al.
    • Organizer
      11th LIPOSOME RESEARCH DAYS CONFERENCE
    • Place of Presentation
      神奈川、横浜シンポジア
    • Year and Date
      2008-07-22
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] 腫瘍選択的活性化をプログラムしたsiRNAデリバリーシステムの開発2008

    • Author(s)
      畠山浩人, 他
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      東京、六本木アカデミーヒルズ
    • Year and Date
      2008-06-30
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] Development of systemic siRNA delivery for tumor with specific ally tumor activation system2008

    • Author(s)
      H. Hatakeyama, et.al.
    • Organizer
      The 11th Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      米国、ボストン、Hynes Convention Center
    • Year and Date
      2008-06-01
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] 腫瘍選択的活性化型血清耐性MENDによるsiRNA送達システムの構築2008

    • Author(s)
      櫻井遊, 畠山浩人, 他
    • Organizer
      北海道支部第131回例会
    • Place of Presentation
      北海道、北海道薬科大学
    • Year and Date
      2008-11-29
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] evelopment of systemic siRNA delivery for tumor with specifically tumor activation system2008

    • Author(s)
      H. Hatakeyama, H. Akita, E. Ito, M. Oishi, Y. Nagasaki, H. Harashima
    • Organizer
      he 11th Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      Boston, MA, USA
    • Data Source
      KAKENHI-PROJECT-20890003
  • [Presentation] Systemic siRNA Delivery Using a Maltifunctional Nanodevice with Programmed Tumor Activation.2008

    • Author(s)
      H.Hatakeyama, et al.
    • Organizer
      11th LIPOSOME RESEARCH DAYS CONFERENCE
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-07-22
    • Data Source
      KAKENHI-PROJECT-20015003
  • 1.  佐野 誠 (70339323)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  HARASHIMA Hideyoshi (00183567)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 3.  Sato Hiromi (30506887)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  紙谷 浩之 (10204629)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  山田 勇磨 (60451431)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  馬場 嘉信 (30183916)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  秋田 英万 (80344472)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 8.  樋坂 章博 (80420206)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  新留 琢郎 (20264210)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  NAKAMURA Hiroyukii
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  OSADA Kensuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  櫻井 遊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 13.  中村 孝司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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