Tonami Kazuo 礪波一夫

… Alternative Names

TONAMI Kazuo 礪波一夫

礪波一夫トナミカズオ

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Researcher Number	70511393
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2020: 東京大学, 大学院医学系研究科(医学部), 助教 2015 – 2016: 東京大学, 大学院医学系研究科(医学部), 助教 2014: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員 2011: Tokyo Metropolitan Organization for Medical Research, 研究員 2010: (財)東京都医学総合研究所, 東京都臨床医学総合研究所, 研究員
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 48010:Anatomy-related Except Principal Investigator Functional biochemistry
Keywords	Principal Investigator 細胞骨格 / カルパイン / 低分子量Gタンパク質 / アクチン / 数理モデル / 回転運動 / VE-カドヘリン / 集団的細胞運動 / 血管内皮細胞 / 血管新生 … More / 動脈硬化 / 骨格筋 / 筋分化 / グアニンヌクレオチド交換因子 / 微小管 / 細胞運動 / プロテアーゼ … More Except Principal Investigator 遺伝子改変マウス / 組織特異的発現 / 基質特異性 / 酵素学 / 自己消化 / 胃腸疾患 / 筋ジストロフィー / 質量分析 / プロテオリシス / カルパイン Less

Analysis of molecular mechanisms underlying endothelial cell behaviors as a fundamental process of angiogenesisPrincipal Investigator
- Principal Investigator
  
  Tonami Kazuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  The University of Tokyo
Functional analysis of non-proteolytic calpain to the skeletal muscle development via RhoA activityPrincipal Investigator
- Principal Investigator
  
  Tonami Kazuo
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
Tissue-specific functional studies on calpains
- Principal Investigator
  
  SORIMACHI Hiroyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
カルパインの新しいプロテアーゼ非依存性機能による細胞骨格・運動性の制御機構Principal Investigator
- Principal Investigator
  
  礪波一夫
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Metropolitan Organization for Medical Research

All 2021 2020 2019 2018 2017 2016 2013 2012 2010 Other

All Journal Article Presentation

[Journal Article] 血管内皮細胞の動態モデルの3次元への拡張について2021
- Author(s)
  酒井一馬，林達也，時弘哲治，礪波一夫，栗原裕基
- Journal Title
  
  津田塾大学数学・計算機科学研究所報
  
  Volume: 42 Pages: 141-147
- Data Source
  KAKENHI-PROJECT-18K06817
[Journal Article] Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation2021
- Author(s)
  Arima Yuichiro、Nakagawa Yoshiko、Takeo Toru、Ishida Toshifumi、Yamada Toshihiro、et al.
- Journal Title
  
  Nature Metabolism
  
  Volume: 3 Issue: 2 Pages: 196-210
- DOI
  10.1038/s42255-021-00342-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08110, KAKENHI-PROJECT-19K08520, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-20H04108, KAKENHI-PROJECT-18K06817, KAKENHI-PROJECT-19K22639, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K09008, KAKENHI-PROJECT-19K17403, KAKENHI-PROJECT-19H04446, KAKENHI-PROJECT-21H02686, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-21K19519, KAKENHI-PROJECT-20KK0185, KAKENHI-PROJECT-18H02798, KAKENHI-PROJECT-19H01048
[Journal Article] Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.2016
- Author(s)
  Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A
- Journal Title
  
  J Clin Invest
  
  Volume: 126 Issue: 9 Pages: 3417-3432
- DOI
  10.1172/jci85880
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02389, KAKENHI-PROJECT-26460454, KAKENHI-PROJECT-26461149, KAKENHI-PROJECT-26461368, KAKENHI-PROJECT-15K21367, KAKENHI-PROJECT-26860588, KAKENHI-PROJECT-15K07944, KAKENHI-PROJECT-15K09418, KAKENHI-PROJECT-16K10553, KAKENHI-PROJECT-26450172, KAKENHI-PROJECT-15H02536
[Journal Article] Calpain-6 deficiency promotes skeletal muscle development and regeneration.2013
- Author(s)
  Tonami, K., Hata, S., Ojima, K., Ono, Y., Kurihara, Y., Amano, T., Sato, T., Kawamura, Y., Kurihara, H., Sorimachi, H.
- Journal Title
  
  PLOS Genetics
  
  Volume: 9 Issue: 8 Pages: 1003668-1003668
- DOI
  10.1371/journal.pgen.1003668
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11J02638, KAKENHI-PROJECT-23247021, KAKENHI-PROJECT-23590326, KAKENHI-PROJECT-23780152, KAKENHI-PUBLICLY-24115705, KAKENHI-PROJECT-24249047
[Journal Article] Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1
- Author(s)
  礪波一夫
- Journal Title
  
  Journal of Cell Science
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790272
[Presentation] 血管新生の数理モデル-3次元への拡張-2021
- Author(s)
  酒井一馬，林達也，間田潤，時弘哲治，礪波一夫，栗原裕基
- Organizer
  日本応用数理学会2021年研究部会連合発表会
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] Analysis of molecular mechanisms underlying contact-dependent rotational movement of endothelial cells2021
- Author(s)
  礪波一夫, 林達也, 劉瀟瀟, 牛島俊征, 内島泰信, 栗原由紀子, 時弘哲治, 栗原裕基
- Organizer
  第28回日本血管生物医学会学術集会（CVMW2020）
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] 血管新生に関わる内皮細胞の特徴的回転運動における分子動態の解析2020
- Author(s)
  礪波一夫, 劉瀟瀟, 牛島俊征, 内島泰信, 栗原由紀子, 栗原裕基
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] 血管内皮細胞の動態モデルの3次元への拡張について2020
- Author(s)
  酒井一馬，林達也，時弘哲治，礪波一夫，栗原裕基
- Organizer
  津田塾大学数学・計算機科学研究所オンライン研究集会「非線形波動から可積分系へ」
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] 単一細胞遺伝子発現ネットワークの分析による血管新生調節機構の解析2019
- Author(s)
  内島泰信, 戸澤英人, 岩瀬晃康, 礪波一夫, 田久保直子, 栗原由紀子, 田口明糸, 椎名香織, 小林美佳, 山本尚吾, 仲木竜, 興梠貴英, 油谷浩幸, 和田洋一郎, 栗原裕基
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] 血管新生における内皮細胞のパターン形成機構の解明2019
- Author(s)
  礪波一夫, 林達也, 金井政宏, 由良文孝, 間田潤, 須賀原啓, 劉瀟瀟, 内島泰信, 時弘哲治, 栗原裕基
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] Mathematical modeling for endothelial cell migration during sprouting angiogenesis2019
- Author(s)
  Tatsuya Hayashi, Fumitaka Yura, Yuri Kominami, Jun Mada, Tetsuji Tokihiro, Kazuo Tonami, Hiroki Kurihara
- Organizer
  The 20th International Conference on Systems Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] 血管新生の基盤となる血管内皮細胞に特有な細胞間相互作用の同定とその制御機構の解析2019
- Author(s)
  礪波一夫, 林達也, 金井政宏, 由良文孝, 間田潤, 劉瀟瀟, 須賀原啓, 内島泰信, 時弘哲治, 栗原裕基
- Organizer
  第27回日本血管生物医学会学術集会（心血管代謝週間2019）
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] Analysis of single endothelial cell behaviors as a fundamental process of sprouting angiogenesis2018
- Author(s)
  礪波一夫、金井政宏、牛島俊征、内島泰信、栗原裕基
- Organizer
  Weinstein Cardiovascular Development and Regeneration Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] 血管新生を可能にする内皮細胞の協調動態とその分子基盤の解析2018
- Author(s)
  礪波一夫、金井政宏、牛島俊征、須賀原啓、内島泰信、栗原裕基
- Organizer
  第26回日本血管生物医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] 血管新生における血管内皮細胞の基本動態に関する数理モデル2018
- Author(s)
  林達也、由良文孝、間田潤、時弘哲治、礪波一夫、栗原裕基
- Organizer
  日本応用数理学会2018年年会
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] 血管新生の素過程としての内皮細胞動態とその分子基盤の解析2018
- Author(s)
  礪波一夫、金井政宏、牛島俊征、須賀原啓、内島泰信、栗原裕基
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06817
[Presentation] 細胞の協調動態の観察とモデリング2017
- Author(s)
  礪波　一夫,　金井　政宏,　戸澤　英人,　牛島　俊征,　田久保　直子,　内島　泰信,　時弘哲治, 栗原　裕基
- Organizer
  生命動態合同シンポジウム2017
- Place of Presentation
  理化学研究所　生命システム研究センター（大阪府吹田市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K21367
[Presentation] Disturbance of pre-mRNA splicing by calpain-6 aggravates macrophage cholesterol deposition in atherosclerotic lesions2016
- Author(s)
  Takuro Miyazaki, Kazuo Tonami, Shoji Hata, Toshihiro Aiuchi, Koji Ohnishi, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Motohiro Takeya, Hiroyuki Itabe, Hiroyuki Sorimachi, Hiroki Kurihara and Akira Miyazaki
- Organizer
  第２４回血管生物医学会学術集会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2016-12-09
- Data Source
  KAKENHI-PROJECT-15K21367
[Presentation] Calpain-6 potentiates pro-atherogenic pinocytosis in macrophages2016
- Author(s)
  Takuro Miyazaki, Kazuo Tonami, Shoji Hata, Toshihiro Aiuchi, Koji Ohnishi, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Motohiro Takeya, Hiroyuki Itabe, Hiroyuki Sorimachi, Hiroki Kurihara and Akira Miyazaki
- Organizer
  19th International Vascular Biology Meeting
- Place of Presentation
  ボストン（U.S.A）
- Year and Date
  2016-11-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21367
[Presentation] カルパイン機能不全と疾患 Calpains in health and disease2013
- Author(s)
  反町洋之、秦勝志、礪波一夫、大内史子、小野弥子
- Organizer
  日本薬学会第133回年会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23247021
[Presentation] Towards understanding the enigmatic substrate specificity of calpains2012
- Author(s)
  Sorimachi, H., duVerle, D., Hata, S., Tonami, K., Ouchi, F., Ojima, K., Takigawa, I., Mamitsuka, H. and Ono, Y.
- Organizer
  XIIIth Symposium on Proteases, Inhibitors and Biological Control
- Place of Presentation
  Portoroz, Slovenia
- Invited
- Data Source
  KAKENHI-PROJECT-23247021
[Presentation] 活性中心を欠失した新規カルパインによる細胞骨格・運動性制御機能の解明2010
- Author(s)
  礪波一夫
- Organizer
  BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22790272
[Presentation] Novel function of Calpain 6 in cytoskeletal organization and its implication in cell physiology2010
- Author(s)
  礪波一夫
- Organizer
  FASEB Summer Research Conferences
- Place of Presentation
  Carefree, Arizona, USA(招待講演)
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-22790272
[Presentation] Extended concept for calpain “activity” – non-proteolytic functions of unconventional calpains.
- Author(s)
  Sorimachi, H., Tonami, K., Shinkai-Ouchi, F., Hata, S., Ojima, K., and Ono, Y.
- Organizer
  FASEB Summer Research Conferences – Biology of Calpains in Health & Disease
- Place of Presentation
  Vermont, USA.
- Year and Date
  2013-07-21 – 2013-07-26
- Invited
- Data Source
  KAKENHI-PROJECT-23247021

1. SORIMACHI Hiroyuki (10211327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. ONO Yasuko (20392376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. HATA Shoji (10392375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. MATSUOKA Kunie (40291158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MIYAZAKI Takuro (80398693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Tonami Kazuo 礪波 一夫

TONAMI Kazuo 礪波 一夫

礪波 一夫 トナミ カズオ

Research Projects

Research Products

Co-Researchers

Analysis of molecular mechanisms underlying endothelial cell behaviors as a fundamental process of angiogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of non-proteolytic calpain to the skeletal muscle development via RhoA activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tissue-specific functional studies on calpains

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

カルパインの新しいプロテアーゼ非依存性機能による細胞骨格・運動性の制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 血管内皮細胞の動態モ デルの3次元への拡張について2021

Author(s)

Journal Title

Data Source

[Journal Article] Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calpain-6 deficiency promotes skeletal muscle development and regeneration.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1

Author(s)

Journal Title

Data Source

[Presentation] 血管新生の数理モデル-3次元への拡張-2021

Author(s)

Organizer

Data Source

[Presentation] Analysis of molecular mechanisms underlying contact-dependent rotational movement of endothelial cells2021

Author(s)

Organizer

Data Source

[Presentation] 血管新生に関わる内皮細胞の特徴的回転運動における分子動態の解析2020

Author(s)

Organizer

Data Source

[Presentation] 血管内皮細胞の動態モデルの3次元への拡張について2020

Author(s)

Organizer

Data Source

[Presentation] 単一細胞遺伝子発現ネットワークの分析による血管新生調節機構の解析2019

Author(s)

Organizer

Data Source

[Presentation] 血管新生における内皮細胞のパターン形成機構の解明2019

Author(s)

Organizer

Data Source

[Presentation] Mathematical modeling for endothelial cell migration during sprouting angiogenesis2019

Author(s)

Organizer

Tonami Kazuo 礪波一夫

TONAMI Kazuo 礪波一夫

礪波一夫トナミカズオ

[Journal Article] 血管内皮細胞の動態モデルの3次元への拡張について2021