Uemura Masako 植村雅子

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UEMURA Masako 植村雅子

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Researcher Number	70511997
Affiliation (Current)	2025: 鈴鹿医療科学大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2016 – 2023: 鈴鹿医療科学大学, 薬学部, 助教 2012 – 2015: 鈴鹿医療科学大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy
Keywords	Principal Investigator 抗がん剤 / 大腸がん / 白金錯体 / 細胞輸送 / 耐性がん / 細胞内蓄積 / トランスポーター / 細胞内蓄積量 / オキサリプラチン耐性 / 構造活性相関 … More / 癌 / 薬学 / シスプラチン耐性がん / グルタチオン / がん幹細胞 / 次世代白金制がん剤 … More Except Principal Investigator 金属錯体 / DDS / がん / 核酸 / 白金 / 免疫 / 抗腫瘍効果 / 白金製剤 / 白金錯体 / 創薬 / 薬物耐性 / DNA / 制がん剤 / ナノ粒子 / アルブミン / プロテオミクス / EPR / シスプラチン / 細胞内取込 / 白金制がん剤 / 細胞内蓄積 / 大腸がん / オキサリプラチン / 難治性がん / アゾール / テトラゾール Less

白金二核錯体の免疫賦活作用機序の解明とDDS化
- Principal Investigator
  
  米田誠治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Suzuka University of Medical Science
Study of anticancer platinum dinuclear complex on transport mechanism and in vitro cytotoxicity toward oxaliplatin-resistant colorectal tumorPrincipal Investigator
- Principal Investigator
  
  UEMURA Masako
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Suzuka University of Medical Science
Development of a next-generation platinum-based drug with a markedly high and long-lasting antitumor efficacy
- Principal Investigator
  
  Komeda Seiji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Suzuka University of Medical Science
Screening for cancer stem cell-targeted dinuclear platinum(II) complexPrincipal Investigator
- Principal Investigator
  
  Uemura Masako
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Suzuka University of Medical Science
Drug discovery research based on dinuclear platinum complexes with markedly high antitumor activity
- Principal Investigator
  
  Komeda Seiji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Suzuka University of Medical Science
Development of next-generation anticancer drugs using dinuclear transition metal complexes
- Principal Investigator
  
  KOMEDA Seiji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Suzuka University of Medical Science

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 Other

All Journal Article Presentation Book

[Book] Modern Avenues in Metal-Nucleic Acid Chemistry (Ch. 8: How do cationic Pt(II) complexes modify the higher-order structure of DNA?)2023
- Author(s)
  Seiji Komeda, Masako Uemura, Kenichi Yoshikawa, Yuko Yoshikawa (Ch. 8) Jens Muller, Bernhard Lippert (Eds.)
- Total Pages
  464
- Publisher
  Taylor & Francis Group
- ISBN
  9781032218175
- Data Source
  KAKENHI-PROJECT-19K16340
[Journal Article] Introduction of Fluorine into Antitumor-Active Dinuclear Platinum(II) Complexes Leads to Modulation of In Vivo Antitumor Activity in Mice2022
- Author(s)
  Uemura M., Hiramoto K., Yoneyama H., Harusawa S., Komeda S.
- Journal Title
  
  Inorganic Chemistry
  
  Volume: 61 Issue: 31 Pages: 12155-12164
- DOI
  10.1021/acs.inorgchem.2c01126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16340, KAKENHI-PROJECT-19K07018
[Journal Article] Data on synthesis and structure?activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes2022
- Author(s)
  Komeda Seiji、Yoneyama Hiroki、Uemura Masako、Tsuchiya Takahiro、Hoshiyama Miyuu、Sakazaki Tomoya、Hiramoto Keiichi、Harusawa Shinya
- Journal Title
  
  Data in Brief
  
  Volume: 40 Pages: 107697-107708
- DOI
  10.1016/j.dib.2021.107697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16340, KAKENHI-PROJECT-19K07018
[Journal Article] Synthesis and structure-activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes: A small modification at tetrazole C5 markedly influences the in vivo antitumor efficacy2019
- Author(s)
  Komeda S., Yoneyama H., Uemura M., Tsuchiya T., Hoshiyama M., Sakazaki T., Hiramoto K., Harusawa S.
- Journal Title
  
  Journal of Inorganic Biochemistry
  
  Volume: 192 Pages: 82-86
- DOI
  10.1016/j.jinorgbio.2018.12.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15436
[Journal Article] In Vitro Cytotoxicity and In Vivo Antitumor Efficacy of Tetrazolato-Bridged Dinuclear Platinum(II) Complexes with a Bulky Substituent at Tetrazole C52019
- Author(s)
  Komeda S., Uemura M., Yoneyama H., Harusawa S., Hiramoto K.
- Journal Title
  
  Inorganics
  
  Volume: 7 Issue: 1 Pages: 5-5
- DOI
  10.3390/inorganics7010005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15436
[Journal Article] Specific Conformational Change in Giant DNA Caused by Anticancer2017
- Author(s)
  S. Komeda, H. Yoneyama, M. Uemura, A. Muramatsu, N. Okamoto,
- Journal Title
  
  Inorg. Chem.
  
  Volume: 56 Issue: 2 Pages: 802-811
- DOI
  10.1021/acs.inorgchem.6b02239
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460160, KAKENHI-PROJECT-15K07905, KAKENHI-PLANNED-25103012
[Journal Article] Kinetic analysis of and platinum(II) migration in the reactions of tetrazolato-bridged dinuclear platinum(II) complexes with nucleotides.2017
- Author(s)
  Uemura M., Komeda S.
- Journal Title
  
  J Inorg Biochem.
  
  Volume: 177 Pages: 359-367
- DOI
  10.1016/j.jinorgbio.2017.08.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15436, KAKENHI-PROJECT-15K07905
[Journal Article] Chromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex.2016
- Author(s)
  Imai R, Komeda S, Shimura M, Tamura S, Matsuyama S, Nishimura K, Rogge R, Matsunaga A, Hiratani I, Takata H, Uemura M, Iida Y, Yoshikawa Y, Hansen JC, Yamauchi K, Kanemaki MT, Maeshima K.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 24712-24725
- DOI
  10.1038/srep24712
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07905, KAKENHI-PROJECT-16K15095, KAKENHI-PROJECT-16H04746
[Journal Article] Highly efficient uptake into cisplatin-resistant cells and the isomerization upon coordinative DNA binding of anticancer tetrazolato-bridged dinuclear platinum(II) complexes.2015
- Author(s)
  Uemura M, Hoshiyama M, Furukawa A, Sato T, Higuchi Y, Komeda S.
- Journal Title
  
  Metallomics
  
  Volume: 7 Issue: 11 Pages: 1488-1496
- DOI
  10.1039/c5mt00174a
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07905
[Journal Article] Second- and Higher-order Structural Changes of DNA Induced by Antitumor-Active Tetrazolato-Bridged Dinuclear Platinum(II) 　Complexes with Different Types of 5-Substituent.2013
- Author(s)
  Uemura, M.; Yoshikawa, Y.; Sato, T.; Mino, Y.; Yoshikawa, K.; Chikuma, M.; Komeda, S.
- Journal Title
  
  J Inorg Biochem
  
  Volume: 127 Pages: 169-174
- DOI
  10.1016/j.jinorgbio.2013.05.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590063
[Journal Article] An in vivo highly antitumor-active tetrazolato-bridged dinuclear platinum(ii) complex largely circumvents in vitro cisplatin resistance : two linkage isomers yield the same product upon reaction with 9-ethylguanine but exhibit different cytotoxic profiles2012
- Author(s)
  Uemura M, Suzuki T, Nishio K, Chikuma M, Komeda S.
- Journal Title
  
  Metallomics
  
  Volume: 4(in press) Issue: 7 Pages: 686-692
- DOI
  10.1039/c2mt20026k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790173, KAKENHI-PROJECT-24590063
[Journal Article] A circular cichroism study uncovers a two-step interaction of antitumor azolato-bridged dinuclear platinum(II) complexes with calf thymus DNA2012
- Author(s)
  Masako Uemura
- Journal Title
  
  Metallomics
  
  Volume: 4 Issue: 7 Pages: 641-644
- DOI
  10.1039/c2mt20022h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510123, KAKENHI-PROJECT-24590063
[Presentation] oxaliplatin耐性大腸がん細胞に対する白金(II)二核錯体の細胞毒性評価2024
- Author(s)
  植村雅子、米山弘樹、宇佐美吉英、春沢信哉、米田誠治
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] 抗がん活性を有するアゾラト架橋白金(II)二核錯体とアデノシンにより形成される新奇な8員環キレート錯体2024
- Author(s)
  山田拓磨、植村雅子、箕浦克彦、米田誠治
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06074
[Presentation] DNAのコアセルベートを誘導する白金錯体の探索2024
- Author(s)
  田代竜、山田拓磨、矢野芹佳、荒木礼子、西原大樹、中川萌、植村雅子、米田誠治
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-23K06074
[Presentation] oxaliplatin耐性大腸がん細胞に対する白金(II)二核錯体の細胞毒性評価2024
- Author(s)
  植村雅子、米山弘樹、宇佐美吉英、春沢信哉、米田誠治
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06074
[Presentation] 抗腫瘍活性を有する白金(II)二核錯体の細胞内蓄積量に対するトランスポータの影響2023
- Author(s)
  植村雅子、米田誠治
- Organizer
  第32回金属の関与する生体関連反応シンポジウム（SRM2023）
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] 抗腫瘍活性を有する白金(II)二核錯体の細胞輸送におけるトランスポーターの関与2023
- Author(s)
  植村雅子、米山弘樹、宇佐美吉英、春沢信哉、米田誠治
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] 末端アルキンを導入したテトラゾラト架橋白金(II)二核錯体の合成と細胞毒性2023
- Author(s)
  若山実希、米山弘樹、植村雅子、宇佐美吉英、米田誠治
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] Influence of Transporters on Cellular Accumulation of Antitumor-active Dinuclear Platinum(II) Complex2023
- Author(s)
  植村雅子、米田誠治
- Organizer
  第32回金属の関与する生体関連反応シンポジウム
- Data Source
  KAKENHI-PROJECT-23K06074
[Presentation] 抗腫瘍活性を有する白金(II)二核錯体の細胞輸送におけるトランスポーターの関与2023
- Author(s)
  植村雅子、米田誠治
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] Antitumor and immunostimulatory activities of the tetrazolato-bridged dinuclear Pt(II) complexes2022
- Author(s)
  Komeda Seiji、Hiramoto Keiichi、Uemura Masako、Yoneyama Hiroki、Usami Yoshihide、Harusawa Shinya
- Organizer
  10th Asian Biological Inorganic Chemistry Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] In vitro and in vivo activity of fluoromethyl group-introduced antitumor-active dinuclear platinum(II) complex2022
- Author(s)
  Uemura Masako、Hiramoto Keiichi、Yoneyama Hiroki、Usami Yoshihide、Harusawa Shinya、Komeda Seiji
- Organizer
  The 8th International Symposium on Metallomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] 抗腫瘍活性を有する白金(II)二核錯体のoxaliplatin耐性大腸がんに対するin vitro活性評価2022
- Author(s)
  植村雅子、米田誠治
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] Tetrazolato-bridged dinuclear Pt(II) complexes and their potential applications in cancer chemotherapy2022
- Author(s)
  Komeda Seiji、Uemura Masako、Hiramoto Keiichi
- Organizer
  The 8th International Symposium on Metallomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] 抗腫瘍効果を発揮するテトラゾラト架橋白金(II)二核錯体の開発研究2022
- Author(s)
  植村雅子、米田誠治
- Organizer
  第33回日本微量元素学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] In vivo anticancer efficacy and X-ray crystal structure of the tetrazolato-bridged dinuclear Pt(II) complex2022
- Author(s)
  Yamada Takuma、Hiramoto Keiichi、Uemura Masako、Komeda Seiji
- Organizer
  10th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] 抗腫瘍効果を発揮するテトラゾラト架橋白金(II)二核錯体の開発研究2022
- Author(s)
  植村雅子、米田誠治
- Organizer
  第33回日本微量元素学会学術集会（BRTE33）
- Invited
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] Synthesis and characterization of tetrazolato-bridged dinuclear platinum(II) complexes with terminal alkynes2022
- Author(s)
  若山実希、米山弘樹、植村雅子、宇佐美吉英、春沢信哉、米田誠治
- Organizer
  第31回金属の関与する生体関連反応シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] 抗腫瘍活性を有する白金(II)二核錯体のoxaliplatin耐性大腸がんに対するin vitro活性評価2022
- Author(s)
  植村雅子、米田誠治
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] 末端アルキンを導入したテトラゾラト架橋白金(II)二核錯体の合成と細胞毒性2022
- Author(s)
  若山実希、米山弘樹、植村雅子、宇佐美吉英、春沢信哉、米田誠治
- Organizer
  第68回日本薬学会東海支部大会
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] in vitro/in vivo activity of fluoromethyl group-introduced antitumor-active dinuclear platinum(II) complex2022
- Author(s)
  Masako UEMURA, Keiichi HIRAMOTO, Hiroki YONEYAMA, Yoshihide USAMI, Shinya HARUSAWA, and Seiji KOMEDA
- Organizer
  8th ISM (International Symposium on Metallomics)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] 末端アルキンを導入した新規テトラゾラト架橋白金(II)二核錯体の合成2022
- Author(s)
  若山実希、米山弘樹、植村雅子、宇佐美吉英、米田誠治
- Organizer
  第68回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] Introduction of fluorine into antitumor-active dinuclear platinum(II) complex changes in vitro/in vivo activity2021
- Author(s)
  植村雅子、平本恵一、米山弘樹、宇佐美吉英、春沢信哉、米田誠治
- Organizer
  第30回金属の関与する生体関連反応シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] 抗腫瘍活性を有する白金(II)二核錯体へのフッ素導入によるin vitro/in vivo活性の変化2021
- Author(s)
  植村雅子、平本恵一、米山弘樹、宇佐美吉英、春沢信哉、米田誠治
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] 抗腫瘍活性を有する白金(II)二核錯体へのフッ素導入によるin vitro/in vivo活性の変化2021
- Author(s)
  植村雅子、平本恵一、米山弘樹、宇佐美吉英、春沢信哉、米田誠治
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] 抗腫瘍活性を有する白金(II)二核錯体のin vitro/in vivo活性に対するフッ素導入効果2021
- Author(s)
  植村雅子、平本恵一、米山弘樹、宇佐美吉英、春沢信哉、米田誠治
- Organizer
  第30回金属の関与する生体関連反応シンポジウム（SRM2021）
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] 含フッ素白金(II)二核錯体のマウス大腸がんにおける細胞内蓄積量とin vitroおよびin vivo活性評価2020
- Author(s)
  植村雅子、平本恵一、米山弘樹、春沢信哉、米田誠治
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] 「型破りな」制がん白金錯体のin vivo 抗腫瘍効果2020
- Author(s)
  米田誠治、植村雅子、平本恵一
- Organizer
  生命金属に関する合同年会（ConMetal 2020）
- Invited
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] 含フッ素白金(II)二核錯体のマウス大腸がんにおける細胞内蓄積量とin vitroおよびin vivo活性評価2020
- Author(s)
  植村雅子、平本恵一、米山弘樹、宇佐美吉英、春沢信哉、米田誠治
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] 「型破りな」制がん白金錯体のin vivo 抗腫瘍効果2020
- Author(s)
  植村雅子、平本恵一、米田誠治
- Organizer
  生命金属に関する合同年会　Consortium of Metal Biosciences 2020 プログラム
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] テトラゾール5位にかさ高い置換基を導入したテトラゾラト架橋錯体のin vitro細胞毒性とin vivo抗腫瘍効果2019
- Author(s)
  植村雅子、平本恵一、米山弘樹、春沢信哉、米田誠治
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-17K15436
[Presentation] Development of Next-Generation Platinum-Based Drug with Markedly High and Long-Lasting Antitumor Efficacy2019
- Author(s)
  Seiji Komeda、Masako Uemura、Keiichi Hiramoto
- Organizer
  第29回金属の関与する生体関連反応シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] Development of Next-generation Platinum-based Drug with Markedly High and Long-lasting Antitumor Efficacy2019
- Author(s)
  米田誠治、植村雅子、平本恵一
- Organizer
  第28回金属の関与する生体関連反応シンポジウム（SRM2019）
- Data Source
  KAKENHI-PROJECT-19K16340
[Presentation] In Vitro Cytotoxicity and In Vivo Antitumor Efficacy of Tetrazolato-Bridged Dinuclear Platinum(II) Complexes with a Bulky Substituent at Tetrazole C52019
- Author(s)
  Masako Uemura、Keiichi Hiramoto、Hiroki Yoneyama、Shinya Harusawa、Seiji Komeda
- Organizer
  15th International Symposium on Applied Bioinorganic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07018
[Presentation] メチル基を有するテトラゾラト架橋白金(II)二核錯体のDNAとの相互作用および細胞内取り込みにおけるフッ素導入効果の検討2018
- Author(s)
  植村雅子、米山弘樹、春沢信哉、米田誠治
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-17K15436
[Presentation] DNA interaction and cellular uptake study of highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complexes.2018
- Author(s)
  Uemura, M.; Komeda, S.
- Organizer
  43rd International Conference on Coordination Chemistry (ICCC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15436
[Presentation] メチル基を有するテトラゾラト架橋白金(II)二核錯体のDNAとの相互作用および細胞内取り込みにおけるフッ素導入効果の検討2018
- Author(s)
  植村雅子，米山弘樹，春沢信哉，米田誠治
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] 含フッ素テトラゾラト架橋白金(II)二核錯体のDNAとの相互作用およびがん細胞増殖抑制活性2018
- Author(s)
  植村雅子, 米田誠治
- Organizer
  第63回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K15436
[Presentation] テトラゾラト架橋白金(II)二核錯体の in vitro 細胞毒性と in vivo 抗腫瘍効果2018
- Author(s)
  米田誠治、植村雅子、平本恵一、米山弘樹、春沢信哉
- Organizer
  第27回金属の関与する生体関連反応シンポジウム（SRM2018）
- Data Source
  KAKENHI-PROJECT-17K15436
[Presentation] 顕著な抗腫瘍効果を有する白金(II)二核錯体のユニークな作用機構2017
- Author(s)
  植村雅子、米田誠治、吉川研一、吉川祐子、春沢信哉、米山弘樹
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] DNA interaction and structure-activity telationship of tetrazolato-bridged dinuclear platinum(II) complexes with fluoromethyl group2017
- Author(s)
  植村雅子，米山弘樹，坂﨑智哉，長江紀樹，小井阪あゆみ，春沢信哉，米田誠治
- Organizer
  第27回金属の関与する生体関連反応シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] 制がん白金(II)二核錯体のDNA凝縮能および細胞内取り込みに関する研究2017
- Author(s)
  植村雅子、吉川祐子、吉川研一、米田誠治
- Organizer
  第63回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K15436
[Presentation] DNA Interactions and Structure-Activity Relationship of Tetrazolato-Bridged Dinuclear Platinum(II) Complexes with Methyl and Fluoromethyl Group2017
- Author(s)
  Uemura M., Komeda S.
- Organizer
  12th International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy (ISPCC2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15436
[Presentation] フルオロメチル基を有するテトラゾラト架橋白金(II)二核錯体のDNAとの相互作用および構造活性相関2017
- Author(s)
  植村雅子、米山弘樹、坂﨑智哉、長江紀樹、小井阪あゆみ、春沢信哉、米田誠治
- Organizer
  第26回金属の関与する生体関連反応シンポジウム（SRM2017）
- Data Source
  KAKENHI-PROJECT-17K15436
[Presentation] 制がん白金(II)二核錯体のDNA凝縮能および細胞内取り込みに関する研究2017
- Author(s)
  植村雅子, 米山弘樹, 岡本直人, 村松晃, 福田青郎, 小西宏明, 髙木陽光, 松﨑健, 春沢信哉, 吉川祐子, 今中忠行, 吉川研一，米田誠治
- Organizer
  第63回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] Structure-activity relationships, DNA compaction efficiencies and intracellular accumulations on anticancer-active tetrazolato-bridged dinuclear platinum(II) complexes2017
- Author(s)
  Komeda, S.; Uemura, M.; Hiramoto, K.; Yoshikawa, Y.; Yoshikawa, K.; Yoneyama, H.; Harusawa, S.
- Organizer
  14th International Symposium on Applied Bioinorganic Chemistry
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] DNA interactions and structure-activity relationship of tetrazolato-bridged dinuclear platinum(II) complexes with methyl and fluoromethyl group2017
- Author(s)
  Uemura, M.; Yoneyama, H.; Harusawa, S.; Komeda, S.
- Organizer
  12th International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] Covalent interaction of anticancer azolato-bridged dinuclear platinum(II) complexes with nucleotide and double-helical DNA2016
- Author(s)
  Uemura, M.; Komeda, S.
- Organizer
  金属の関与する生体関連反応シンポジウム (SRM2016)
- Place of Presentation
  札幌市
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] 長短鎖アルキル基を導入した制がんテトラゾラト架橋白金(II)二核錯体の細胞内取込およびDNA凝縮能2016
- Author(s)
  米田誠治, 植村雅子, 米山弘樹, 岡本直人, 村松晃, 福田青郎, 小西宏明, 髙木陽光, 松﨑健, 春沢信哉, 吉川祐子, 今中忠行, 吉川研一
- Organizer
  日本薬学会第136年会横浜市年月日201603-201603
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] Biological efficiency of anticancer tetrazolato-bridged dinuclear platinum(II) complexes with different length of alkyl substituent in relation to the structural effect of DNA2016
- Author(s)
  Komeda, S.; Uemura, M.; Yoneyama, H.; Muramatsu, A.; Okamoto, N.; Harusawa, S.; Yoshikawa, Y.; Yoshikawa, K.
- Organizer
  金属の関与する生体関連反応シンポジウム (SRM2016)
- Place of Presentation
  札幌市
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] Significant effect of dinuclear Pt(II) complexes on the higher-order structure of genomic DNA2016
- Author(s)
  Shimizu, Y.; Yoshikawa, Y.; Uemura, M.; Kenmotsu, T.; Komeda, S.; Yoshikawa, K.
- Organizer
  8th Asian Biological Inorganic Chemistry Conference
- Place of Presentation
  ニュージーランド　オークランド
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] Cellular uptake and DNA compaction of anticancer tetrazolato-bridged dinuclear platinum(II) complexes with various substituents at tetrazole C52015
- Author(s)
  Uemura, M; Yoneyama, H; Yoshikawa, T; Tsuchiya, T; Hoshiyama, M; Sato, T; Yoshikawa, K; Harusawa, S; Komeda, S
- Organizer
  第25回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  長崎市
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] Cellular uptake and DNA compaction of anticancer tetrazolato-bridged dinuclear platinum(II) complexes with various substituents at tetrazole C52015
- Author(s)
  Uemura, M; Yoneyama, H; Yoshikawa, T; Tsuchiya, T; Hoshiyama, M; Sato, T; Yoshikawa, K; Harusawa, S; Komeda, S
- Organizer
  1st International Symposium on Clinical and Experimental Metallodrugs in Medicine: Cancer Chemotherapy
- Place of Presentation
  米国ハワイ州
- Year and Date
  2015-12-13
- Data Source
  KAKENHI-PROJECT-15K07905
[Presentation] 新規制がんテトラゾラト架橋白金(II)二核錯体の合成、細胞毒性およびDNAとの相互作用2013
- Author(s)
  米田誠治，岡本直人，植村雅子，米山弘樹，春沢信哉，小西宏明，高木陽光，松崎健
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] テトラゾール5位にエステル基を導入した制がん白金(II)二核錯体の合成およびin vitro 細胞毒性2013
- Author(s)
  土屋考弘，米山弘樹，春沢信哉，小西宏明，髙木陽光，松﨑健，植村雅子，米田誠治
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2013
- Place of Presentation
  鈴鹿市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] テトラゾール5位に飽和アルキル基を導入した制がん白金(II)二核錯体のDNAとの相互作用2013
- Author(s)
  岡本直人，植村雅子，米山弘樹，春沢信哉，小西宏明，髙木陽光，松﨑健，吉川祐子，今中忠行，吉川研一，米田誠治
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2013
- Place of Presentation
  鈴鹿市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] Second- and higher-order structural changes of DNA induced by antitumor-active 5-alkyl-tetrazolato-bridged dinuclear platinum(II) complexes2013
- Author(s)
  植村雅子，岡本直人，米山弘樹，春沢信哉，吉川研一，吉川祐子，今中忠行，小西宏明，髙木陽光，松﨑健，千熊正彦，米田誠治
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  西東京市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] プロテオミクスを用いた制がん白金錯体5-H-Yによるタンパク質発現変動解析2013
- Author(s)
  佐藤誠泰，古川絢子，植村雅子，樋口善弘，米田誠治
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2013
- Place of Presentation
  鈴鹿市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] A circular dichroism study on the activity of antitumor- active tetrazolato-bridged dinuclear Pt(II) complex derivatives to change secondary structure of DNA2012
- Author(s)
  Uemura, M.; Chikuma, M.; Komeda, S.
- Organizer
  11th European Biological Inorganic Chemistry Conference
- Place of Presentation
  スペイン　グラナダ市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] DNA Conformational Changes Induced by Antitumor Tetrazolato-Bridged Dinuclear Pt(II) Complexes2012
- Author(s)
  植村雅子，藤澤豊，定金豊，飯田靖彦，森井孫俊，千熊正彦，米田誠治
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] 新規テトラゾラト架橋白金（II）二核錯体の合成、細胞毒性およびDNA との相互作用2012
- Author(s)
  岡本直人，植村雅子，米山弘樹，春沢信哉，小西宏明，高木陽光，松崎健，米田誠治
- Organizer
  第3回メタロミクス研究フォーラム
- Place of Presentation
  町田市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] 制がん活性を有するテトラゾラト架橋白金(II)二核錯体によるDNAの濃度および時間依存的二次構造変化2012
- Author(s)
  植村雅子，千熊正彦，米田誠治
- Organizer
  第6回バイオ関連化学シンポジウム
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] Synthesis, biological evaluation and DNA interaction of the series of antitumor azolato-bridged dinuclear platinum(II) complexes2012
- Author(s)
  Komeda, S.; Uemura, M.; Yoshikawa, Y. Chikuma, M.; Yamori, T.
- Organizer
  11th European Biological Inorganic Chemistry Conference
- Place of Presentation
  スペイン　グラナダ市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] In vivo 制がん活性を有するアゾラト架橋白金(II)二核錯体の創薬研究2012
- Author(s)
  米田誠治，植村雅子，吉川祐子，千熊正彦，矢守隆夫
- Organizer
  錯体化学会第62回討論会
- Place of Presentation
  富山市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] In vivo highly antitumor- active tetrazolato-bridged dinuclear platinum(II) complexes2012
- Author(s)
  米田誠治，植村雅子，吉川祐子，千熊正彦，矢守隆夫
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢市
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] 制がん tetrazolato 架橋白金(II)二核錯体の構造活性相関と細胞内取り込み
- Author(s)
  植村雅子，米山弘樹，土屋考弘，星山美有，古川絢子，樋口善博，佐藤卓史，春沢信哉，米田誠治
- Organizer
  第4回メタロミクス研究フォーラム
- Place of Presentation
  西東京市
- Year and Date
  2014-11-07 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] 細胞内取込量および DNA 結合能に基づいた制がん tetrazolato 架橋白金 (II)二核錯体の構造活性相関
- Author(s)
  植村雅子，星山美有，古川絢子，樋口善博，米田誠治
- Organizer
  第24回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都市
- Year and Date
  2014-06-14 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-24590063
[Presentation] テトラゾール 5 位に置換基を導入した制がんテトラゾラト架橋白金(II)二核錯体の細胞内取り込みと構造活性相関
- Author(s)
  植村雅子，米山弘樹，土屋考弘，星山美有，古川絢子，樋口善博，春沢信哉，米田誠治
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590063

1. KOMEDA Seiji (60425056)

# of Collaborated Projects: 5 results

# of Collaborated Products: 61 results
2. HIRAMOTO Keiichi (90251793)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. HARUSAWA Shinya (90167601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
4. YONEYAMA Hiroki (90627001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. YOSHIKAWA Yuko (80291871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. 古川絢子 (10455537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUZUKI Toshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uemura Masako 植村 雅子

UEMURA Masako 植村 雅子

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白金二核錯体の免疫賦活作用機序の解明とDDS化

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Study of anticancer platinum dinuclear complex on transport mechanism and in vitro cytotoxicity toward oxaliplatin-resistant colorectal tumorPrincipal Investigator

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Development of a next-generation platinum-based drug with a markedly high and long-lasting antitumor efficacy

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Screening for cancer stem cell-targeted dinuclear platinum(II) complexPrincipal Investigator

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Drug discovery research based on dinuclear platinum complexes with markedly high antitumor activity

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Development of next-generation anticancer drugs using dinuclear transition metal complexes

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[Book] Modern Avenues in Metal-Nucleic Acid Chemistry (Ch. 8: How do cationic Pt(II) complexes modify the higher-order structure of DNA?)2023

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[Journal Article] Introduction of Fluorine into Antitumor-Active Dinuclear Platinum(II) Complexes Leads to Modulation of In Vivo Antitumor Activity in Mice2022

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[Journal Article] Data on synthesis and structure?activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes2022

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[Journal Article] Synthesis and structure-activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes: A small modification at tetrazole C5 markedly influences the in vivo antitumor efficacy2019

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[Journal Article] In Vitro Cytotoxicity and In Vivo Antitumor Efficacy of Tetrazolato-Bridged Dinuclear Platinum(II) Complexes with a Bulky Substituent at Tetrazole C52019

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[Journal Article] Specific Conformational Change in Giant DNA Caused by Anticancer2017

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[Journal Article] Kinetic analysis of and platinum(II) migration in the reactions of tetrazolato-bridged dinuclear platinum(II) complexes with nucleotides.2017

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[Journal Article] Chromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex.2016

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Uemura Masako 植村雅子

UEMURA Masako 植村雅子

[Journal Article] Second- and Higher-order Structural Changes of DNA Induced by Antitumor-Active Tetrazolato-Bridged Dinuclear Platinum(II) 　Complexes with Different Types of 5-Substituent.2013