FUTAMURA YUSHI 二村友史

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FUTAMURA Yushi 二村友史

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Researcher Number	70525857
Other IDs
Affiliation (Current)	2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 上級研究員 2023: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 2022: 早稲田大学, 理工学術院総合研究所(理工学研究所), 次席研究員(研究院講師) 2021: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 2017 – 2019: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 … More 2013 – 2014: 独立行政法人理化学研究所, 長田抗生物質研究室, 訪問研究員 2012: 独立行政法人理化学研究所, 化学情報・化合物創製チーム, 協力研究員 2011: 独立行政法人理化学研究所, 化学情報・化合物創製チーム, 特別研究員 2010: 独立行政法人理化学研究所, 化学情報・化合物創製チーム, 基礎科学特別研究員 Less
Review Section/Research Field	Principal Investigator Chemical biology / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 37030:Chemical biology-related / Living organism molecular science Except Principal Investigator Medium-sized Section 38:Agricultural chemistry and related fields / Bioorganic chemistry / Living organism molecular science
Keywords	Principal Investigator ケミカルバイオロジー / カンジダ / 銅キレート剤 / 二形性制御 / カンジダアラビカンス / 抗真菌剤 / 二形性 / がん微小環境 / 微小環境 / がん代謝 … More / ポストゲノム創薬 / バイオプローブ / モルフォベース / 微生物代謝産物 / モルフォローム / ハイコンテントスクリーニング / 細胞形態変化 … More Except Principal Investigator ケミカルバイオロジー / 人工知能 / 抗真菌剤 / 二次代謝産物 / 生物活性物質 / エンドサイトーシス / 小分子化合物 / 癌 Less

銅キレート剤を使ったカンジダの出芽機構の解明Principal Investigator
- Principal Investigator
  
  二村友史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Institute of Physical and Chemical Research
Chemical biology for dimorphism in Candida sppPrincipal Investigator
- Principal Investigator
  
  FUTAMURA YUSHI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Physical and Chemical Research
  Waseda University
Exploration of antifungals based on AI-based screening systems
- Principal Investigator
  
  Osada Hiroyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Institute of Physical and Chemical Research
Exploration of small molecules that target cancer specific metabolismPrincipal Investigator
- Principal Investigator
  
  Futamura Yushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Institute of Physical and Chemical Research
Creation of bioactive compounds by activation and engineering of microbial secondary metabolite biosynthetic genes
- Principal Investigator
  
  Osada Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Institute of Physical and Chemical Research
Drug discovery based on MorphoBase, an encyclopedia of cell morphologyPrincipal Investigator
- Principal Investigator
  
  FUTAMURA Yushi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  The Institute of Physical and Chemical Research
Development of anti-cancer agents targeting the endocytic pathway
- Principal Investigator
  
  KAWATANI Makoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research
Development of the cell morphology database for drug and bioprobe discoveryPrincipal Investigator
- Principal Investigator
  
  FUTAMURA Yushi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Concepts and Case Studies in Chemical Biology2014
- Author(s)
  Osada H, Muroi M, Kondoh Y, Futamura Y
- Total Pages
  464
- Publisher
  Wiley-VCH
- Data Source
  KAKENHI-PROJECT-25750396
[Journal Article] Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc2023
- Author(s)
  LIU ZIYU、OKANO AKIKO、SANADA EMIKO、FUTAMURA YUSHI、NOGAWA TOSHIHIKO、ISHIKAWA KOSUKE、SEMBA KENTARO、LI JIANG、LI XIAOMENG、OSADA HIROYUKI、WATANABE NOBUMOTO
- Journal Title
  
  Oncology Research
  
  Volume: 31 Issue: 5 Pages: 655-666
- DOI
  10.32604/or.2023.030248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05319, KAKENHI-PROJECT-21H04720
[Journal Article] cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo2023
- Author(s)
  Kato Naoki、Ebihara Kana、Nogawa Toshihiko、Futamura Yushi、Inaba Kazue、Okano Akiko、Aono Harumi、Fujikawa Yuuta、Inoue Hideshi、Matsuda Kazuhiko、Osada Hiroyuki、Niwa Ryusuke、Takahashi Shunji
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 8 Pages: e0290851-e0290851
- DOI
  10.1371/journal.pone.0290851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-21K05319, KAKENHI-PUBLICLY-23H04564, KAKENHI-PROJECT-23K26843
[Journal Article] Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F0582023
- Author(s)
  Nogawa Toshihiko、Kato Naoki、Shimizu Takeshi、Okano Akiko、Futamura Yushi、Takahashi Shunji、Koshino Hiroyuki、Osada Hiroyuki
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 76 Issue: 6 Pages: 346-350
- DOI
  10.1038/s41429-023-00613-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-20K05872, KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-21K05319, KAKENHI-PUBLICLY-23H04564, KAKENHI-PROJECT-21H04720, KAKENHI-PROJECT-23K26843
[Journal Article] Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities2022
- Author(s)
  Abdelhakim IA, Motoyama Takayuki, Nogawa Toshihiko, Mahmud FB, Futamura Yushi, Takahashi Shunji, Osada Hiroyuki
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: ahead of print Issue: 7 Pages: 361-374
- DOI
  10.1038/s41429-022-00529-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-20K05820, KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-20H00416, KAKENHI-PROJECT-21H04720, KAKENHI-PROJECT-21K19099
[Journal Article] Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-942021
- Author(s)
  A. Abdelhakim Islam、Bin Mahmud Fauze、Motoyama Takayuki、Futamura Yushi、Takahashi Shunji、Osada Hiroyuki
- Journal Title
  
  Journal of Natural Products
  
  Volume: 85 Issue: 1 Pages: 63-69
- DOI
  10.1021/acs.jnatprod.1c00677
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-20K05820, KAKENHI-PROJECT-21K19099, KAKENHI-PROJECT-21H04720, KAKENHI-PROJECT-20H00416, KAKENHI-PLANNED-17H06412
[Journal Article] 2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture2021
- Author(s)
  Lopez Julius Adam V、Nogawa Toshihiko、Yoshida Kazuko、Futamura Yushi、Osada Hiroyuki
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 86 Issue: 1 Pages: 31-36
- DOI
  10.1093/bbb/zbab192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-21H04720, KAKENHI-PLANNED-17H06412
[Journal Article] Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana2020
- Author(s)
  Sako Kaori、Futamura Yushi、Shimizu Takeshi、Matsui Akihiro、Hirano Hiroyuki、Kondoh Yasumitsu、Muroi Makoto、Aono Harumi、Tanaka Maho、Honda Kaori、Shimizu Kenshirou、Kawatani Makoto、Nakano Takeshi、Osada Hiroyuki、Noguchi Ko、Seki Motoaki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 8691-8691
- DOI
  10.1038/s41598-020-65614-9
- NAID
  120006876594
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-18K14441, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H02140, KAKENHI-PROJECT-18K05366
[Journal Article] A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.2019
- Author(s)
  Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H.
- Journal Title
  
  FEBS Lett.
  
  Volume: 593 Issue: 8 Pages: 763-776
- DOI
  10.1002/1873-3468.13361
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-17K07783, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-18K09000, KAKENHI-PUBLICLY-19H05302
[Journal Article] Structure and biological activity of metarhizin C, a new stereoisomer of BR-050 from a fungus Tolypocladium album RK17-F00072019
- Author(s)
  Nogawa T., Kawatani M., Okano A., Futamura Y., Aono H., Shimizu T., Kato N., Kikuchi H., and Osada H.
- Journal Title
  
  J. Antibiot.
  
  Volume: 72 Issue: 12 Pages: 996-1000
- DOI
  10.1038/s41429-019-0229-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04665, KAKENHI-PROJECT-17H01472, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-17K07784
[Journal Article] Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.2019
- Author(s)
  Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, Nogawa T, Osada H.
- Journal Title
  
  Biochim Biophys Acta Proteins Proteom.
  
  Volume: 1867 Issue: 1 Pages: 28-37
- DOI
  10.1016/j.bbapap.2018.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-17K07783, KAKENHI-PROJECT-17K07784, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-16K01941
[Journal Article] YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001.2019
- Author(s)
  Yamamoto K, Futamura Y, Uson-Lopez RA, Aono H, Shimizu T, Osada H.
- Journal Title
  
  J Antibiot
  
  Volume: 72 Issue: 12 Pages: 986-990
- DOI
  10.1038/s41429-019-0239-z
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-17K01970
[Journal Article] Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F0582018
- Author(s)
  Nogawa T, Kato N, Shimizu T, Okano A, Futamura Y, Takahahi S, Osada H
- Journal Title
  
  The Journal of Antibiotica
  
  Volume: 71 Issue: 1 Pages: 123-128
- DOI
  10.1038/ja.2017.103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07784, KAKENHI-PUBLICLY-17H05454, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H04905
[Journal Article] Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I2018
- Author(s)
  Robke Lucas、Futamura Yushi、Konstantinidis Georgios、Wilke Julian、Aono Harumi、Mahmoud Zhwan、Watanabe Nobumoto、Wu Yao-Wen、Osada Hiroyuki、Laraia Luca、Waldmann Herbert
- Journal Title
  
  Chemical Science
  
  Volume: 9 Issue: 11 Pages: 3014-3022
- DOI
  10.1039/c7sc05040b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01970
[Journal Article] Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684.2017
- Author(s)
  Nogawa T, Ogita N, Futamura Y, Negishi S, Watanabe N, Osada H
- Journal Title
  
  J Antibiot
  
  Volume: 70 Issue: 5 Pages: 705-707
- DOI
  10.1038/ja.2016.167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-17K07784
[Journal Article] RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441.2017
- Author(s)
  Jang JP, Takahashi S, Futamura Y, Nogawa T, Jang JH, Ahn JS, Osada H
- Journal Title
  
  J Antibiot
  
  Volume: 70 Issue: 1 Pages: 102-104
- DOI
  10.1038/ja.2016.65
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-17K07784
[Journal Article] Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355.2017
- Author(s)
  Nogawa T, Okano A, Lim CL, Futamura Y, Shimizu T, Takahashi S, Ibrahim D, Osada H
- Journal Title
  
  J Antibiot
  
  Volume: 70 Issue: 2 Pages: 222-225
- DOI
  10.1038/ja.2016.113
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Journal Article] Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum.2017
- Author(s)
  Jang JP, Nogawa T, Futamura Y, Shimizu T, Hashizume D, Takahashi S, Jang JH, Ahn JS, Osada H
- Journal Title
  
  J Nat Prod
  
  Volume: 80 Issue: 1 Pages: 134-140
- DOI
  10.1021/acs.jnatprod.6b00758
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-17K07784, KAKENHI-PROJECT-16H04905
[Journal Article] Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea2017
- Author(s)
  Otaka Junnosuke、Hashizume Daisuke、Masumoto Yui、Muranaka Atsuya、Uchiyama Masanobu、Koshino Hiroyuki、Futamura Yushi、Osada Hiroyuki
- Journal Title
  
  Organic Letters
  
  Volume: 19 Issue: 15 Pages: 4030-4033
- DOI
  10.1021/acs.orglett.7b01784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07724, KAKENHI-PUBLICLY-17H05430, KAKENHI-PROJECT-17H06173, KAKENHI-PROJECT-15H02445
[Journal Article] Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field2016
- Author(s)
  Son S, Ko SK, Kim JW, Lee JK, Jang M, Ryoo IJ, Hwang GJ, Kwon MC, Shin KS, Futamura Y, Hong YS, Oh H, Kim BY, Ueki M, Takahashi S, Osada H, Jang JH, Ahn JS.
- Journal Title
  
  Phytochemistry
  
  Volume: 122 Pages: 154-164
- DOI
  10.1016/j.phytochem.2015.12.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Journal Article] Proteomic profiling reveals that collismycin A is an iron chelator.2016
- Author(s)
  Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 38385-38385
- DOI
  10.1038/srep38385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16H06276
[Journal Article] An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae2016
- Author(s)
  Shinohara Y, Kawatani M, Futamura Y, Osada H, Koyama Y
- Journal Title
  
  J Antibiot
  
  Volume: 69 Issue: 1 Pages: 4-8
- DOI
  10.1038/ja.2015.73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-16K01941
[Journal Article] New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S0062016
- Author(s)
  Son S, Ko SK, Jang M, Kim JW, Kim GS, Lee JK, Jeon ES, Futamura Y, Ryoo IJ, Lee JS, Oh H, Hong YS, Kim BY, Takahashi S, Osada H, Jang JH, Ahn JS.
- Journal Title
  
  Mar Drugs
  
  Volume: 14 Issue: 4 Pages: 72-72
- DOI
  10.3390/md14040072
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Journal Article] Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase2016
- Author(s)
  Muroi M, Futamura Y, Osada H
- Journal Title
  
  Nat Prod Rep
  
  Volume: 33 Issue: 5 Pages: 621-625
- DOI
  10.1039/c5np00106d
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H06276
[Journal Article] Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library2016
- Author(s)
  Lim CL., Nogawa T., Okano A., Futamura Y., Kawatani M., Takahashi S. Ibrahim D., Osada H.
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: AOP Issue: 6 Pages: 456-458
- DOI
  10.1038/ja.2015.124
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16K01941
[Journal Article] High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism.2016
- Author(s)
  Subedi A, Futamura Y, Nishi M, Ryo A, Watanabe N, Osada H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 477 Issue: 4 Pages: 737-742
- DOI
  10.1016/j.bbrc.2016.06.128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02445
[Journal Article] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.2016
- Author(s)
  Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 26521-26521
- DOI
  10.1038/srep26521
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-15K16563, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16H06276
[Journal Article] RK-270A-C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270.2015
- Author(s)
  Jang JP, Nogawa T, Uramoto M, Okano A, Futamura Y, Shimizu T, Takahashi S, Jang JH, Ahn JS, Osada H.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 68 Issue: 4 Pages: 293-295
- DOI
  10.1038/ja.2014.141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24619011, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-15H02445
[Journal Article] Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems.2013
- Author(s)
  Futamura Y, Kawatani M, Muroi M, Aono H, Nogawa T, Osada H,
- Journal Title
  
  ChemBioChem
  
  Volume: 14 Issue: 18 Pages: 2456-2463
- DOI
  10.1002/cbic.201300499
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24102536, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25750396
[Journal Article] Target identification of small molecules based on chemical biology approaches.2013
- Author(s)
  Yushi Futamura、他
- Journal Title
  
  Mol Biosyst
  
  Volume: 9 Issue: 5 Pages: 897-914
- DOI
  10.1039/c2mb25468a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25750396, KAKENHI-PUBLICLY-24102536
[Journal Article] 新たな抗がん剤探索を加速する新スクリーニング技術2013
- Author(s)
  長田裕之、二村友史、他
- Journal Title
  
  細胞工学
  
  Volume: 32 Pages: 655-59
- Data Source
  KAKENHI-PROJECT-25750396
[Journal Article] Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.2012
- Author(s)
  Futamura Y., Kawatani M., Kazami S., Tanaka K., Muroi M., Shimizu T., Tomita K., Watanabe N., and Osada H.
- Journal Title
  
  Chem. Biol.
  
  Volume: 19 Pages: 1620-1630
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR2011
- Author(s)
  Futamura Y
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 14049-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710228
[Journal Article] Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.2011
- Author(s)
  Futamura, Y., et al.
- Journal Title
  
  Chem Biol.
  
  Volume: 19 Issue: 12 Pages: 1620-1630
- DOI
  10.1016/j.chembiol.2012.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19057005, KAKENHI-PROJECT-22681034, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24510320, KAKENHI-PUBLICLY-24102536
[Presentation] Phenotypic screenings, iHOPE and MorphoBase, for antifungal discovery2024
- Author(s)
  Yushi Futamura
- Organizer
  The URICAS2024 conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05319
[Presentation] 抗カンジダ物質TPPBの構造活性相関とタンパク質－化合物間相互作用解析2024
- Author(s)
  青野晴美、二村友史、堀康宏、室井誠、平野弘之、本田香織、西浦正芳、侯召民、木野邦器、長田裕之
- Organizer
  日本農芸化学会 2024年度大会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] 抗カンジダ物質TPPBの構造活性相関とタンパク質－化合物間相互作用解析2024
- Author(s)
  青野晴美、二村友史、堀康宏、室井誠、平野弘之、本田香織、西浦正芳、侯召民、木野邦器、長田裕之
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-21K05319
[Presentation] A novel inhibitor of fungal cell wall synthesis that targets RHO1 small GTPase2023
- Author(s)
  Yushi Futamura, Harumi Aono, Rachael Uson-Lopez, Yasuhiro Hori, Makoto Muroi, Hiroyuki Hirano, Masayoshi Nishiura, Zhaomine Hou, Hiroyuki Osada
- Organizer
  5th KRIBB-RIKEN Chemical Biology Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05319
[Presentation] AI-based screening system for antifungal substances by monitoring morphological changes of Aspergillus oryzae2023
- Author(s)
  Harumi Aono, Yushi Futamura, Hiroyuki Uno, Kuniki Kino, Hiroyuki Osada
- Organizer
  5th KRIBB-RIKEN Chemical Biology Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] 低分子量G タンパク質RHO1 をターゲットとする新規真菌細胞壁合成阻害物質の発見2023
- Author(s)
  二村友史、堀康宏、長田裕之
- Organizer
  第67回日本医真菌学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K05319
[Presentation] 麹菌の細胞形態を学習させたAIモデルによる抗真菌剤の探索2023
- Author(s)
  二村友史、卯野宏幸、木野邦器、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] 低分子量G タンパク質RHO1 をターゲットとする新規真菌細胞壁合成阻害物質の発見2023
- Author(s)
  二村友史、堀康宏、長田裕之
- Organizer
  第67回日本医真菌学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] カンジダの二形性を阻害するSF2768の作用機序解析2023
- Author(s)
  二村友史、青野晴美、山本甲斐、清水猛、ウソン-ロペスレイチェル、堀康宏、木野邦器、長田裕之
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-21K05319
[Presentation] 抗カンジダ物質TPPBの作用機序解析2023
- Author(s)
  青野晴美、二村友史、堀康宏、室井誠、平野弘之、西浦正芳、侯召民、木野邦器、長田裕之
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] 表現型解析で拓く抗真菌剤探索2023
- Author(s)
  二村友史
- Organizer
  理研‐早稲田シンポジウム2023
- Invited
- Data Source
  KAKENHI-PROJECT-21K05319
[Presentation] 抗カンジダ物質TPPBの作用機序解析2023
- Author(s)
  青野晴美、二村友史、堀康宏、室井誠、平野弘之、西浦正芳、侯召民、木野邦器、長田裕之
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-21K05319
[Presentation] Identification of new lucilactaene derivatives with potent antimalarial activity2023
- Author(s)
  Yushi Futamura, Amin Adel Abdelhakim, Takayuki Motoyama, Fauze Bin Mahmud, Harumi Aono, Nobumoto Watanabe, Shunji Takahashi, Kuniki Kino, Hiroyuki Osada
- Organizer
  International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] 麹菌の形態変化を指標とするAI駆動型抗真菌剤スクリーニング系の構築2023
- Author(s)
  卯野宏幸、二村友史、長田裕之、木野邦器
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] 表現型を活用した抗真菌剤の探索研究2023
- Author(s)
  二村友史
- Organizer
  第33回新薬創製談話会
- Invited
- Data Source
  KAKENHI-PROJECT-21K05319
[Presentation] カンジダの二形性を阻害するSF2768の作用機序解析2023
- Author(s)
  二村友史、青野晴美、山本甲斐、清水猛、ウソン-ロペスレイチェル、堀康宏、木野邦器、長田裕之
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] A novel inhibitor of fungal cell wall synthesis that targets RHO1 small GTPase2023
- Author(s)
  Yushi Futamura, Harumi Aono, Rachael Uson-Lopez, Yasuhiro Hori, Makoto Muroi, Hiroyuki Hirano, Masayoshi Nishiura, Zhaomine Hou, Hiroyuki Osada
- Organizer
  5th KRIBB-RIKEN Chemical Biology Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] カンジダの細胞形態変化を指標とした抗真菌剤の探索2022
- Author(s)
  二村友史、ウソン－ロペスレイチェル A.、青野晴美、堀康宏、室井誠、平野弘之、西浦正芳、侯召民、長田裕之
- Organizer
  日本農芸化学会 2022年度大会
- Data Source
  KAKENHI-PROJECT-21K05319
[Presentation] Mode of action study of a potent antimalarial compound, dihydrolucilactaene2022
- Author(s)
  Yushi Futamura, Fauze Bin Mahmud, Harumi Aono, Nobumoto Watanabe, Kuniki Kino, Hiroyuki Osada
- Organizer
  International Union of Microbiological Societies 2022 (IUMS 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] カンジダの細胞形態変化を指標とした抗真菌剤の探索2022
- Author(s)
  二村友史、ウソン－ロペスレイチェル、青野晴美、堀康宏、室井誠、平野弘之、西浦正芳、侯召民、長田裕之
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] カンジダ細胞の表現型変化を指標とした抗真菌剤の探索2021
- Author(s)
  二村友史、ウソン－ロペスレイチェル A. 、青野晴美、堀康宏、渡邉慶子、室井誠、平野弘之、西浦正芳、侯召民、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] カンジダ細胞の表現型変化を指標とした抗真菌剤の探索2021
- Author(s)
  二村友史、ウソン－ロペスレイチェル A.、青野晴美、堀康宏、渡邉慶子、室井誠、平野弘之、西浦正芳、侯召民、長田裕之
- Organizer
  日本ケミカルバイオロジー学会　第15回年会
- Data Source
  KAKENHI-PROJECT-21K05319
[Presentation] A cancer stemness inhibitor induces the activation of the serine biosynthetic pathway upon mitochondrial inhibition2019
- Author(s)
  Watanabe N, Muroi M, Futamura Y, Kawamura T, Aono H, Osada H.
- Organizer
  The 78th Annual Meeting of Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-17K01970
[Presentation] GLUT1欠損がん細胞を用いたエネルギー代謝スイッチ機構の解析2019
- Author(s)
  川谷誠, 青野晴美, 堂前直, 二村友史, 室井誠, 長田裕之
- Organizer
  日本がん分子標的治療学会第23回学術集会
- Data Source
  KAKENHI-PROJECT-17K01970
[Presentation] 神経芽腫NB-1細胞を用いたがん代謝阻害物質の探索2019
- Author(s)
  青野晴美, 二村友史, 長田裕之
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-17K01970
[Presentation] Analysis of metabolic switch mechanisms using GLUT1 knockout cancer cell2019
- Author(s)
  Aono H, Kawatani M, Dohmae N, Futamura Y, Muroi M, Osada H
- Organizer
  The 78th Annual Meeting of Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-17K01970
[Presentation] ミトコンドリアに作用するがん幹細胞特異的阻害剤は細胞内セリン合成経路を活性化する2019
- Author(s)
  渡辺信元, Amit Subedi, 室井誠, 二村友史, 河村達郎, 青野晴美, 長田裕之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K01970
[Presentation] 担子菌類Coprinopsis cinereaからの新規骨格を有する2種のノルセスキテルペノイド2018
- Author(s)
  大髙潤之介、二村友史、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] がん代謝を阻害するプレニルフラボノイドの作用機序解析2018
- Author(s)
  1.二村友史、青野晴美、佐竹華子、室井誠、川谷誠、野川俊彦、井本正哉、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-17K01970
[Presentation] Exploration of small-molecule inhibitors targeting cancer metabolism2018
- Author(s)
  Aono H, Futamura Y, Kawatani M, Muroi M, Osada H.
- Organizer
  The 9th Japan-Korea Chemical Biology Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01970
[Presentation] NPL40330: A novel oxidative phosphorylation inhibitor identified by bioenergetic and proteomic profiling2018
- Author(s)
  Futamura Y, Muroi M, Aono H, Kawatani M, Osada H.
- Organizer
  30th EORTC-NCI-AACR Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01970
[Presentation] がん代謝研究を加速するオミックス解析基盤の構築2018
- Author(s)
  佐竹華子、二村友史、室井誠、野川俊彦、川谷誠、井本正哉、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 新規アントラキノンkinanthraquinoneの同定と生物活性評価2018
- Author(s)
  高木海、野川俊彦、二村友史、長田裕之、高橋俊二
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] がん代謝を阻害するプレニルフラボノイドの作用機序解析2018
- Author(s)
  二村友史、青野晴美、佐竹華子、室井誠、川谷誠、野川俊彦、井本正哉、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] がん代謝阻害剤スクリーニングと呼吸阻害作用解析2018
- Author(s)
  室井誠、二村友史、青野晴美、川谷誠、関根朋美、野川俊彦、林田莉奈、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物wakodecaline Cの構造2018
- Author(s)
  野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Candida albicansに菌糸形態を誘導する化合物RK-276Aのケミカルバイオロジー研究2018
- Author(s)
  山本甲斐、二村友史、清水猛、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] じゃがいもの新規機能性成分探索に向けたフラクションライブラリーの作製2017
- Author(s)
  野川俊彦, 二村友史, 岡野亜紀子, 石原克之, 須藤麻里, 伊藤政喜, 長田裕之
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] グルコース非依存性がん代謝機構を標的とした小分子阻害剤の探索2017
- Author(s)
  川谷誠、青野晴美、二村友史、室井誠、長田裕之
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Exploration of small molecules targeting cancer metabolism2017
- Author(s)
  二村友史、青野晴美、川谷誠、長田裕之
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Artesunate selectively inhibits of cancer stemness through the mitochondrial dysfunction2017
- Author(s)
  Nobumoto Watanabe, Amit Subedi, Yushi Futamura, Akihide Ryo and Hiroyuki Osada
- Organizer
  RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Exploration of small molecules targeting cancer metabolism.2017
- Author(s)
  Futamura Y, Aono H, Kawatani M, Osada H
- Organizer
  The 76th Annual Meeting of Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-17K01970
[Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物の構造2017
- Author(s)
  野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
- Organizer
  第59回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] がん代謝を標的とする小分子阻害剤の探索2017
- Author(s)
  長田裕之、二村友史、室井誠
- Organizer
  第76回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Application of a fraction library for new metabolites search2017
- Author(s)
  Toshihiko Nogawa, Akiko Okano, Yushi Futamura, Takeshi Shimizu, Nobumoto Watanabe, Shunji Takahashi, Hiroyuki Osada
- Organizer
  3rd KRIBB-RIKEN Chemical Biology Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Exploration of novel antifungal substances based on fungal　morphological changes2017
- Author(s)
  Kai Yamamoto, Yushi Futamura, Takeshi Shimizu, Hiroyuki Osada
- Organizer
  3rd KRIBB-RIKEN Chemical Biology Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] エネルギー代謝を標的とした小分子化合物の探索2017
- Author(s)
  二村友史, 青野晴美, 川谷誠, 長田裕之
- Organizer
  日本がん分子標的治療学会第21回学術集会
- Data Source
  KAKENHI-PROJECT-17K01970
[Presentation] エネルギー代謝を標的とした小分子化合物の探索2017
- Author(s)
  二村友史、川谷誠、青野晴美、長田裕之
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] アルテスネイトはミトコンドリア障害を介して幹細胞特異的生存阻害を引き起こす2017
- Author(s)
  渡辺信元、二村友史、長田裕之
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 真菌の形態変化を指標とした抗真菌物質YO15001A、Bの単離2017
- Author(s)
  山本甲斐、二村友史、長田裕之
- Organizer
  第32回日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] ChemProteoBase を用いた化合物のオフターゲット解析2017
- Author(s)
  室井誠、川谷誠、河村達郎、近藤恭光、二村友史、田中美帆、青野晴美、本田香織、長田裕之
- Organizer
  日本ケミカルバイオロジー学会　第12回年会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] じゃがいもフラクションライブラリーを用いた抗糖化活性の検討2017
- Author(s)
  須藤麻里, 吉原潮梨, 石原克之, 野川俊彦, 二村友史, 岡野亜紀子, 長田裕之
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] グルコース非依存性がん代謝機構を標的とした小分子阻害剤の探索2017
- Author(s)
  川谷誠、青野晴美、二村友史、室井誠、長田裕之
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 酸化ヌクレオチド加水分解酵素MTH1阻害剤の作用解析2016
- Author(s)
  川谷誠, 河村達郎, 室井誠, 青野晴美, 二村友史, 田中美帆, 長田裕之
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Identification of MTH1inhibitors by chemical arrays2016
- Author(s)
  Kawamura T, Kawatani M, Kondoh Y, Muroi M, Futamura Y, Aono H, Tanaka M, Honda K, Osada H
- Organizer
  RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
- Place of Presentation
  Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
- Year and Date
  2016-04-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Analysis of MTH1 inhibitors by ChemProteoBase, the drug-target analysis system based on proteomic profiling.2016
- Author(s)
  Muroi M, Kawatani M, Kawamura T, Futamura Y, Osada H
- Organizer
  The 21st JFCR-International Symposium on Cancer Chemotherapy (JFCR-ISCC)
- Place of Presentation
  Miraikan (National Museum of Emerging Science and Innovation) (Tokyo, Japan)
- Year and Date
  2016-12-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Phenotypic screening of small molecules targeting cancer metabolism2016
- Author(s)
  Futamura Y, Kawatani M, Aono H, Muroi M, Tanaka M, Osada H
- Organizer
  The 8th Korea-Japan Chemical Biology symposium
- Place of Presentation
  Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
- Year and Date
  2016-01-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival2016
- Author(s)
  Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanakaa M, Honda K, Osada H
- Organizer
  28th EORTC-NCI-AACR SYMPOSIUM
- Place of Presentation
  ICM - Internationales Congress Center Munich (Munich, Germany)
- Year and Date
  2016-11-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] アルテスネイトはミトコンドリアを標的として、肝細胞特異的にがん細胞生存を阻害する2016
- Author(s)
  渡辺信元, Amit Sbedi, 二村友史, 梁明秀, 長田裕之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Characterization of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival2016
- Author(s)
  河村達郎, 川谷誠, 室井誠, 青野晴美, 二村友史, 長田裕之
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 真菌の形態変化を指標とした抗真菌物質の探索研究2016
- Author(s)
  山本甲斐, 二村友史, 植木雅志, 鈴木龍一郎, 白瀧義明, 長田裕之
- Organizer
  日本農芸化学会 2016年度大会
- Place of Presentation
  札幌コンベンションセンター札幌市産業振興センター（北海道札幌市)
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 微生物フラクションライブラリーより単離した新規ネオアンチマイシン類縁体ウナンチマイシンAの構造2016
- Author(s)
  野川俊彦, リム・チュンリャン, 岡野亜紀子, 二村友史, 川谷誠, 高橋俊二, ダーラ・イブラヒム, 長田裕之
- Organizer
  日本農芸化学会 2016年度大会
- Place of Presentation
  札幌コンベンションセンター札幌市産業振興センター（北海道札幌市)
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Bioactive compounds from Plant Roots2016
- Author(s)
  Otaka J, Futamura Y, Osada H
- Organizer
  The 8th Korea-Japan Chemical Biology symposium
- Place of Presentation
  Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
- Year and Date
  2016-01-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] エネルギー代謝プロファイリングを用いたがん代謝阻害薬の探索研究2016
- Author(s)
  二村友史, 川谷誠, 青野晴美, 室井誠, 田中美帆, 長田裕之
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] 放線菌Streptomyces sp. RK88-1355より単離した新規Opantimycin Aの構造2016
- Author(s)
  野川俊彦, リム・チュンリャン, 岡野亜紀子, 二村友史, 清水猛, 高橋俊二, 長田裕之
- Organizer
  第58回天然有機化合物討論会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] エネルギー代謝プロファイリングを用いたがん代謝阻害剤の探索研究2016
- Author(s)
  二村友史, 青野晴美, 川谷誠, 室井誠, 長田裕之
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] モルフォベースを基盤とした抗がん物質探索：特異な線状構造体を誘導するNPD4152の発見2015
- Author(s)
  二村友史, 川谷誠, 室井誠, 青野晴美, 長田裕之
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル（愛媛県松山市）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] MorphobaseおよびChemProteoBaseを用いたGN.9482の標的同定2015
- Author(s)
  青野晴美, 川谷誠, 二村友史, 室井誠, 峯岸秀充, 中村浩之, 長田裕之
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル（愛媛県松山市）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Discovery and target identification of pyrrolizilactone, a fungal metabolite2015
- Author(s)
  Hiroyuki Osada, Yushi Futamura, Toshihiko Nogawa
- Organizer
  The international chemical congress of pacific basin societies (Pacifichem) 2015
- Place of Presentation
  Hawaii Convention Center 他（Honolulu, Hawaii, USA）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445
[Presentation] Development and utilization of a cell morphology database, MorphoBase, for drug target identification2013
- Author(s)
  Yushi Futamura、他
- Organizer
  AACR-NCI-EORTC International Conference Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Boston, USA (Hynes Convention Center)
- Data Source
  KAKENHI-PROJECT-25750396
[Presentation] モルフォベースを利用した抗がん剤探索：特異な線状構造体を誘導するNPD4152の発見2013
- Author(s)
  二村友史、他
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜（パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-25750396
[Presentation] Proteome- and cell morphology-based target identification for RKB3564F070, a new cytotoxic fungal metabolite2012
- Author(s)
  Makoto Kawatani, Harumi Aono, Toshihiko Nogawa, Makoto Muroi, Yushi Futamura, and Hiroyuki Osada
- Organizer
  The 1st official conference of the international chemical biology society
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Identification of a molecular target for RKB3564F070, a new cytotoxic fungal metabolite2012
- Author(s)
  川谷誠、青野晴美、室井誠、二村友史、長田裕之
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Identification of NPD3483 as a unique cell division inhibitor via the cell morphology-based screen2010
- Author(s)
  Futamura Y., Osada H.
- Organizer
  22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  ベルリン
- Data Source
  KAKENHI-PROJECT-22710228
[Presentation] The cell morphology-based screen revealed NPD3483 to be a unique type of cell division inhibitor2010
- Author(s)
  Futamura Y., Osada H.
- Organizer
  69th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22710228
[Presentation] Identification of NPD3483 as a unique cell division inhibitor via the cell morphology-based screen2010
- Author(s)
  Yushi Futamura, et al
- Organizer
  22^<nd> EROTC-NCI-AACR symposium on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Berlin, Germany
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-22710228
[Presentation] Screening of bioactive compounds through morphology-based screens2010
- Author(s)
  Futamura Y., Osada H.
- Organizer
  Chemical Biology International Symposium
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-22710228
[Presentation] The cell morphology-based screen revealed NPD3483 to be a unique type of cell division inhibitor2010
- Author(s)
  二村友史, 他
- Organizer
  第69回日本癌学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22710228
[Presentation] 細胞形態変化を指標としたがん分子標的治療薬の探索研究2010
- Author(s)
  二村友史、長田裕
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22710228
[Presentation] 細胞形態変化データベース「モルフォベース」の構築とその応用
- Author(s)
  二村友史
- Organizer
  GE Life Sciences Day 2013
- Place of Presentation
  横浜（パシフィコ横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-25750396

1. MUROI Makoto (30261168)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. Osada Hiroyuki (80160836)

# of Collaborated Projects: 2 results

# of Collaborated Products: 62 results
3. KAWATANI Makoto (50391925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. TAKAHASHI Shunji (30311608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. 加藤直樹 (90442946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 木野邦器 (60318764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. KAZAMI Sayaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. HONDA Kaori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NOGAWA Toshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
10. 本山高幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 越野広雪

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUTAMURA YUSHI 二村 友史

FUTAMURA Yushi 二村 友史

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銅キレート剤を使ったカンジダの出芽機構の解明Principal Investigator

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Chemical biology for dimorphism in Candida sppPrincipal Investigator

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Exploration of antifungals based on AI-based screening systems

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Exploration of small molecules that target cancer specific metabolismPrincipal Investigator

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Creation of bioactive compounds by activation and engineering of microbial secondary metabolite biosynthetic genes

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Drug discovery based on MorphoBase, an encyclopedia of cell morphologyPrincipal Investigator

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Development of anti-cancer agents targeting the endocytic pathway

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Development of the cell morphology database for drug and bioprobe discoveryPrincipal Investigator

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[Book] Concepts and Case Studies in Chemical Biology2014

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[Journal Article] Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc2023

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[Journal Article] cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo2023

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[Journal Article] Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F0582023

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[Journal Article] Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities2022

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[Journal Article] Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-942021

Author(s)

FUTAMURA YUSHI 二村友史

FUTAMURA Yushi 二村友史