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Kasuga Kensaku  春日 健作

… Alternative Names

春日 健作  カスガ ケンサク

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Researcher Number 70547546
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-2178-0769
Affiliation (Current) 2025: 国立研究開発法人国立長寿医療研究センター, 研究所 認知症先進医療開発センター, 部長
2025: 新潟大学, 脳研究所, 助教
Affiliation (based on the past Project Information) *help 2017 – 2023: 新潟大学, 脳研究所, 助教
2017: 新潟大学, 脳研究所, 特任助教
2015 – 2016: 新潟大学, 研究推進機構, 助教
2014: 新潟大学, 研究推進機構超域学術院, 助教
2010: Niigata University, 医歯学総合病院, その他
2009: Niigata University, 医歯学総合病院, 特任助教
Review Section/Research Field
Principal Investigator
Neurology / Basic Section 52020:Neurology-related
Except Principal Investigator
Neurology / Studies on the Super-Aging Society
Keywords
Principal Investigator
Aβ / アルツハイマー病 / Alzheimer's disease / アミロイドβ / アミロイド前駆体蛋白 / 神経活動 / biomarker / CSFバイオマーカー / tau / バイオマーカー … More / CSF / 脳脊髄液 / PSP / 進行性核上性麻痺 / ネットワーク / mRNA / APPプロセッシング / neuronal activity / NMDA受容体 / APP processing / neuronal activation / Phosphorylated tau / Amyloid beta / Neuronal activity / タウ蛋白リン酸化 / タウ蛋白 / リン酸化タウ / インスリンシグナル / βアミロイド … More
Except Principal Investigator
認知症 / サル / 若返り / 血漿タンパク / 老化 / アミノ酸 / ネットワーク / シグナル伝達 / 遺伝子発現 Less
  • Research Projects

    (7 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (13 People)
  •  血漿タンパク成分による老齢ザルの若返り法の開発

    • Principal Investigator
      中村 克樹
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Studies on the Super-Aging Society
    • Research Institution
      Kyoto University
  •  Alzheimer's disease related biomarkers in progressive supranuclear palsyPrincipal Investigator

    • Principal Investigator
      Kasuga Kensaku
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Niigata University
  •  Neuronal activity affects AD pathophysiologyPrincipal Investigator

    • Principal Investigator
      Kasuga Kensaku
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  Validation study on insulin resistance occuring in brain of Alzheimer disease

    • Principal Investigator
      Ikeuchi Takeshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  Amino acid profile in plasma of Alzheimer's disease

    • Principal Investigator
      Ikeuchi Takeshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  Neuronal activity promotes tau phosphorylation via enhancement of APP processingPrincipal Investigator

    • Principal Investigator
      Kasuga Kensaku
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  アルツハイマー病・異常リン酸化タウ蓄積におけるインスリンシグナル伝達障害の関与Principal Investigator

    • Principal Investigator
      春日 健作
    • Project Period (FY)
      2009
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Neurology
    • Research Institution
      Niigata University

All 2022 2021 2019 2018 2017 2015 2009 Other

All Journal Article Presentation Book

  • [Book] 非定型パーキンソニズム2022

    • Author(s)
      春日健作
    • Total Pages
      242
    • Publisher
      文光社
    • ISBN
      9784830615474
    • Data Source
      KAKENHI-PROJECT-19K07991
  • [Journal Article] Efects of super-hard rice bread blended with black rice bran on amyloid beta peptide production and abrupt increase in postprandial blood glucose levels in mice2017

    • Author(s)
      S.Nakamura, T.Hara, T.Joh, A.Kobayashi, A.Yamazaki, K.Kasuga, T.Ikeuchi, K.Ohtsubo
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 81 Issue: 2 Pages: 323-334

    • DOI

      10.1080/09168451.2016.1240605

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02891, KAKENHI-PROJECT-15K15335
  • [Journal Article] Serum microRNA miR-501-3p as a potential biomarker related to the progression of Alzheimer’s disease2017

    • Author(s)
      Hara N, Kikuchi M, Miyashita A, Hatsuta H, Saito Y, Kasuga K, Murayama S, Ikuechi T, Kuwano R
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 5 Pages: 10-10

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04839
  • [Journal Article] Reduced CSF water influx in Alzheimer's disease supporting the b-amyloid clearance hypothesis.2015

    • Author(s)
      Suzuki Y, Nakamura Y, Yamada K, Igarashi H, Kasuga K, Yokoyama Y, Ikeuchi T, Nishizawa M, Kwee IL, Nakada T
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 5 Pages: e0123708-e0123708

    • DOI

      10.1371/journal.pone.0123708

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15335, KAKENHI-PROJECT-25461310
  • [Journal Article] Systematic review and meta-analysis of Japanese familial Alzheimer's disease and FTDP-17.2015

    • Author(s)
      Kasuga,et al
    • Journal Title

      Journal of Human Genetics

      Volume: in press Issue: 5 Pages: 1-3

    • DOI

      10.1038/jhg.2015.15

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25893077, KAKENHI-PROJECT-26870209, KAKENHI-PROJECT-15H04839
  • [Journal Article] ApoE-isoform-dependent cellular uptake of amyloid-β is mediated by lipoprotein receptor LR11/SorLA.2015

    • Author(s)
      Yajima,et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 456 Issue: 1 Pages: 482-488

    • DOI

      10.1016/j.bbrc.2014.11.111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25893077, KAKENHI-PROJECT-15H04839
  • [Journal Article] Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer's disease.2009

    • Author(s)
      Kasuga K, Shimohata T, Nishimura A, Shiga A, Mizuguchi T, Tokunaga J, Ohno T, Miyashita A, Kuwano R, Matsumoto N, Onodera O, Nishizawa M, Ikeuchi T
    • Journal Title

      J Neurol Neurosurg Psychiatry 80

      Pages: 1050-1052

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21890078
  • [Journal Article] The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.2009

    • Author(s)
      Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M
    • Journal Title

      EMBO Mol Med 1

      Pages: 223-235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21890078
  • [Journal Article] Depression and psychiatric symptoms preceeding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation.2009

    • Author(s)
      Kasuga K, Ohno T, Ishihara T, Miyashita A, Kuwano R, Onodera O, Nishizawa M, Ikeuchi T
    • Journal Title

      J Neurol 256

      Pages: 1351-1353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21890078
  • [Journal Article] Differential Levels of alpha-Synuclein, beta-Amyloid42, and Tauin Cerebrospinal Fluids between Patients with Dementia with Lewy Bodies and Alzheimer Disease.

    • Author(s)
      Kasuga K, Tokutake T, Ishikawa A, Uchiyama T, Tokuda T, Onodera O, Nishizawa M, Ikeuchi T
    • Journal Title

      J Neurol Neurosurg Psychiatry (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21890078
  • [Presentation] CSF and blood biomarkers for PSP2021

    • Author(s)
      Kensaku Kasuga
    • Organizer
      62nd Annual Meeting of the Japanese Society of Neurology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07991
  • [Presentation] TIME- AND EXTENT- DEPENDENT EFFECT OF NEURONAL ACTIVATION ON Β-AMYLOID PRECURSOR PROTEIN (APP) PROCESSING2019

    • Author(s)
      Ishiguro T, Kasuga K, Saito K, Mezaki N, Miura T, Tokutake T, Onodera O, Ikeuchi T
    • Organizer
      The 14th International Conference on Alzheimer's & Parkinson's Diseases
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09669
  • [Presentation] 神経細胞興奮がβ-amyloid precursor protein(APP)processingへ及ぼす影響2018

    • Author(s)
      石黒敬信、春日健作、斎藤健智、目﨑直実、三浦健、小野寺理、池内健
    • Organizer
      第37回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09669
  • [Presentation] Identification of serum microRNA as a potential biomarker related to the progression of Alzheimer’s disease.2017

    • Author(s)
      Kuwano R, Hara N, Kikuchi M, Miyashita A, Hatsuta H, Saito Y, Kasuga K, Murayama S, Ikeuchi T
    • Organizer
      Alzheimer's Association International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15335
  • [Presentation] THE EFFECT OF NEURONAL ACTIVITY ON Β-AMYLOID PRECURSOR PROTEIN (APP) PROCESSING IN CULTURED CELLS2017

    • Author(s)
      Ishiguro T, Kasuga K, Saito K, Mezaki N, Miura T, Onodera O, Ikeuchi T
    • Organizer
      World Congress of Neurology 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09669
  • [Presentation] 神経細胞興奮がβ-amyloid precursor protein (APP) processingへ及ぼす影響2017

    • Author(s)
      石黒敬信, 春日健作, 斎藤健智, 目﨑直実, 三浦健, 小野寺理, 池内健
    • Organizer
      第36回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09669
  • [Presentation] Systematic review of Japanese familial Alzheimer’s disease and FTDP-172015

    • Author(s)
      Kasuga K, Kikuchi M, Tokutake T, Nakaya A, Tezuka T, Tsukie T, Hara N, Miyashita A, Kuwano R and Ikeuchi T
    • Organizer
      Alzheimer’s Association International Conference 2015
    • Place of Presentation
      Convention Center, Washington DC, USA
    • Year and Date
      2015-07-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870209
  • [Presentation] 本邦における家族アルツハイマー病データベース(Japanese Familial Alzheimer's Disease database, JFADdb)の構築2015

    • Author(s)
      春日健作、菊地正隆、徳武孝允、手塚敏之、月江珠緒、原範和、宮下哲典、中谷明弘、桑野良三、池内健
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26870209
  • [Presentation] Neuronal activity enhances APP processing in cultured neurons2015

    • Author(s)
      Saito K, Kasuga K and Ikeuchi T
    • Organizer
      Neuroscience annual meeting 2015
    • Place of Presentation
      McCormick Place, IL, USA
    • Year and Date
      2015-10-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870209
  • [Presentation] A role of insulin signaling dysfunction in Alzheimer's disease pathogenesis2009

    • Author(s)
      Kasuga K, Tokutake T, Shinozaki M, Kaneko H, Onodera O, Nishizawa M, Ikeuchi T
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      アメリカ合衆国,イリノイ州,シカゴ
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-21890078
  • [Presentation] Aβはインスリンシグナルを障害することでタウの過剰リン酸化を引き起こすか?2009

    • Author(s)
      春日健作, 徳武孝允, 篠崎眞, 西澤正豊, 小野寺理, 池内健
    • Organizer
      第28回日本認知症学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-21890078
  • [Presentation] 認知症性疾患の髄液バイオマーカーとしてのαシヌクレイシの検討2009

    • Author(s)
      春日健作, 池内健, 石川厚, 徳田隆彦, 中川正法, 小野寺理, 西澤正豊
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2009-05-22
    • Data Source
      KAKENHI-PROJECT-21890078
  • [Presentation] ニワトリと卵, 神経活動とAβ放出

    • Author(s)
      春日健作
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-10-29 – 2014-11-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-26870209
  • 1.  Ikeuchi Takeshi (20372469)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  TOKUTAKE Takayoshi (00707838)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  SATO Naoyuki (70372612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  豊島 靖子 (20334675)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  中村 克樹 (70243110)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  今村 公紀 (80567743)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TEZUKA Toshiyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SAITO Kento
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  MIYASHITA Akinori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  HARA Norikazu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  TSUKIE Tamao
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KAWAI Nobuhiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  OHTSUBO Ken-ichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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