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Oshima Nobu  大嶋 野歩

… Alternative Names

OSHIMA NOBU  大嶋 野歩

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Researcher Number 70571454
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-2178-5241
Affiliation (Current) 2025: 京都大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help 2020 – 2023: 京都大学, 医学研究科, 客員研究員
2017: 京都大学, 医学(系)研究科(研究院), 客員研究員
2016 – 2017: 京都大学, 医学研究科, 客員研究員
2015: 京都大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field
Principal Investigator
Basic Section 55020:Digestive surgery-related / Digestive surgery
Keywords
Principal Investigator
大腸癌 / セラノスティクス / がん代謝 / 超偏極13CMRI / 癌代謝 / 3D培養 / 非臨床POC / 社会実装 / DNP-MRI / 胃がん … More / 大腸がん / LDH阻害剤 / 胃癌 / ワールバーグ効果 / 乳酸脱水素酵素 / 代謝阻害療法 / 代謝 / 膵癌 / OxPhos / 解糖系 / LDH阻害 / ピルビン酸代謝 / 超偏極13C-MRI / LDH阻害薬 / LDH / 転写因子ネットワーク / 薬剤排泄能 / 多様性形成 / 大腸癌幹細胞 / 転写因子 / iPS細胞技術 / 幹細胞生物学 / 人工癌幹細胞 / 癌幹細胞 Less
  • Research Projects

    (3 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (7 People)
  •  Establishment of Non-clinical POC using hyperpolarized MRI and 3D cultured cancer tissue for personalized medicine of metabolic inhibitor therapy.Principal Investigator

    • Principal Investigator
      大嶋 野歩
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kyoto University
  •  Dynamic Imaging of LDH Inhibition in Tumors by 13C-MRI to Treat Colon CancerPrincipal Investigator

    • Principal Investigator
      OSHIMA NOBU
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kyoto University
  •  Application of induced colon cancer stem cells to elucidation of the molecular basis of cancer stem cell property in colon cancer stem cellsPrincipal Investigator

    • Principal Investigator
      OSHIMA NOBU
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyoto University

All 2023 2022 2021 2020 2016 2015

All Journal Article Presentation

  • [Journal Article] Timing of real‐time indocyanine green fluorescence visualization for lymph node dissection during laparoscopic colon cancer surgery2023

    • Author(s)
      Hiromitsu Kinoshita, Kenji Kawada, Yoshiro Itatani, Ryosuke Okamura, Nobu Oshima, Tomoaki Okada, Koya Hida, Kazutaka Obama
    • Journal Title

      Langenbeck's Archives of Surgery

      Volume: 408 Issue: 1 Pages: 92-92

    • DOI

      10.1007/s00423-023-02808-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09054, KAKENHI-PROJECT-23K08153
  • [Journal Article] he Impact of KRAS Status on the Required Surgical Margin Width for Colorectal Liver Metastasis Resection2023

    • Author(s)
      Kentaro Iwaki, Satoshi Kaihara, Tatsuya Koyama, Kai Nakao, Shotaro Matsuda, Kan Toriguchi, Koji Kitamura, Nobu Oshima, Masato Kondo, Hiroki Hashida, Hiroyuki Kobayashi Kenji Uryuhara.
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 6 Pages: 2313-2313

    • DOI

      10.3390/jcm12062313

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K08153
  • [Journal Article] Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo2022

    • Author(s)
      Yutaro Saito, Hiroyuki Yatabe, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Keita Hiraga, Akihiro Eguchi, Yoichi Takakusagi, Keisuke Saito, Nobu Oshima, Hiroshi Ishikita, Kazutoshi Yamamoto, Murali C. Krishna, Shinsuke Sando
    • Journal Title

      Science advances

      Volume: 8 Issue: 13

    • DOI

      10.1126/sciadv.abj2667

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15396, KAKENHI-PUBLICLY-20H05090, KAKENHI-PROJECT-19H00919, KAKENHI-PROJECT-19KK0369, KAKENHI-PROJECT-20H03217, KAKENHI-PROJECT-20K09054, KAKENHI-PROJECT-18H01186
  • [Journal Article] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-Time Monitoring of Pyruvate Metabolic Fluxes in Vivo and Targeting Intra-Tumor Metabolic Plasticity with Small Molecules2022

    • Author(s)
      Nobu OSHIMA, et al.
    • Journal Title

      Journal of the American College of Surgeons

      Volume: 235 Issue: 5 Pages: S5-S16

    • DOI

      10.1097/01.xcs.0000893008.02117.d2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Journal Article] Real-Time insight into in vivo redox status utilizing hyperpolarized [1- 13 C] N-acetyl cysteine2021

    • Author(s)
      Yamamoto K, Opina A, Sail D, Blackman B, Saito K, Brender JR, Malinowski RM, Seki T, Oshima N, Crooks DR, Kishimoto S, Saida Y, Otowa Y, Choyke PL, Jan H. Ardenkjr-Larsen, Mitchell JB, Linehan WM, Swenson RE & Krishna MC
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 12155-12155

    • DOI

      10.1038/s41598-021-90921-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Journal Article] Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma2020

    • Author(s)
      Yamamoto Kazutoshi、Brender Jeffrey R.、Seki Tomohiro、Kishimoto Shun、Oshima Nobu、Choudhuri Rajani、Adler Stephen S.、Jagoda Elaine M.、Saito Keita、Devasahayam Nallathamby、Choyke Peter L.、Mitchell James B.、Krishna Murali C.
    • Journal Title

      Cancer Research

      Volume: 80 Issue: 11 Pages: 2087-2093

    • DOI

      10.1158/0008-5472.can-19-0928

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Journal Article] Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy2020

    • Author(s)
      Oshima N, Ishida R, Kishimoto S, Beebe K, Brender J, Yamamoto K, Urban D, Squadrito GL, Crooks D, Jackson J, Joshi A,
    • Journal Title

      Cell Reports

      Volume: 30 Issue: 6 Pages: 1798-1810.e4

    • DOI

      10.1016/j.celrep.2020.01.039

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Journal Article] 超偏極13CMRIを用いた膵癌に対するLDH阻害治療効果の動的な可視化2020

    • Author(s)
      大嶋野歩, 岸本俊, 石田諒, 愛須佑樹, 岡田倫明, 錦織達人, 板谷喜朗, 久森重夫, 角田茂, 肥田侯矢, 河田健二, 兵藤文紀, 松尾政之, 中本裕士, 小濱和貴, Neckers LM, Krishna MC, 坂井義治
    • Journal Title

      胆と膵

      Volume: 41 Pages: 751-6

    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Journal Article] Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties2020

    • Author(s)
      Rai Ganesha、Urban Daniel J.、Jana Somnath、Muttil Pavan、Anderson Tamara、Kunda Nitesh K.、Oshima Nobu、Cherukuri Murali、、Dang Chi V.、Stott Gordon M.、Neckers Leonard
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 63 Issue: 19 Pages: 10984-11011

    • DOI

      10.1021/acs.jmedchem.0c00916

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Journal Article] Laparoscopic left hemicolectomy with regional lymph node navigation and intracorporeal anastomosis for splenic flexure colon cancer2020

    • Author(s)
      Itatani Yoshiro、Kawada Kenji、Hida Koya、Deguchi Yasunori、Oshima Nobu、Mizuno Rei、Wada Toshiaki、Okada Tomoaki、Sakai Yoshiharu
    • Journal Title

      International Cancer Conference Journal

      Volume: 9 Issue: 4 Pages: 170-174

    • DOI

      10.1007/s13691-020-00424-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09054, KAKENHI-PROJECT-20K17612
  • [Journal Article] iPS細胞と大腸がん-人工大腸がん幹細胞の作製2016

    • Author(s)
      大嶋野歩、青井貴之
    • Journal Title

      G.I.Research

      Volume: 24(2) Pages: 81-89

    • Data Source
      KAKENHI-PROJECT-15K10139
  • [Presentation] 超偏極-核磁気共鳴法による生体内ペプチダーゼ活性の検出および可視化を指向した分子プローブの設計と開発2023

    • Author(s)
      谷田部 浩行, 近藤 洋平, 田村 伊織, 石田 諒, 関 智宏, 高草木 洋一, Elhelaly Abdelazim E., 大嶋 野歩, 兵藤 文紀, 松尾 政之, 山本 和俊, Krishna Murali C., 齋藤 雄太朗, 山東 信介
    • Organizer
      日本分子イメージング学会 第 17 回年会 2
    • Data Source
      KAKENHI-PROJECT-23K08153
  • [Presentation] 臨床医からみた、DNP-MRIの臨床応用への期待2023

    • Author(s)
      大嶋 野歩
    • Organizer
      第2回 DNP研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K08153
  • [Presentation] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-time monitoring of pyruvate metabolic fluxes in vivo and targeting intra-tumor metabolic plasticity with small molecules2022

    • Author(s)
      Nobu Oshima, Yuki Aisu, Ryo Ishida, Shun kishimoto, Shigeo Hisamori, Shigeru Tsunoda, Satoshi Kaihara, Kazutaka Obama, Murali C. Krishna, Len Neckers
    • Organizer
      American College of Surgeons: Owen H Wangensteen Scientific Forum 2022, Excellence in reserach
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] Comprehensive monitoring of pyruvate metabolism in cancer cells and tumors reveals vulnerability to metabolic inhibition therapy with small molecules2022

    • Author(s)
      Nobu Oshima, Yuki Aisu, Shigeo Hisamori, Shigeru Tsunoda, Hiroki Hashida, Kenji Uryuhara, Hiroyuki Kobayashi, Masato Kondo, Koji Kitamura, Satoshi Kaihara, Kazutaka Obama, Krishna C. Murali, Len M. Neckers.
    • Organizer
      The AACR Annual Meeting 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] 超偏極13C-MRIによる腫瘍組織内でのピルビン酸代謝の動的観察とセラノスティクスへの展開2022

    • Author(s)
      大嶋 野歩, 愛須 佑樹, 久森 重夫, 角田 茂, 兵藤 文紀, 松尾 政之, 板谷 喜朗, 橋田 裕毅, 貝原 聡, 小濱 和貴
    • Organizer
      第77回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] A newly designed hyperpolarized molecular probe enables the in vivo detection of aminopeptidase N activity from the tumor regions in animals2022

    • Author(s)
      Hiroyuki Yatabe, Yutaro Saito, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Keita Hiraga, Akihiro Eguchi, Yoichi Takakusagi, Keisuke Saito, Nobu Oshima, Hiroshi Ishikita, Kazutoshi Yamamoto, Murali C. Krishna, Shinsuke Sando
    • Organizer
      World Molecular Imaging Congress (WMIC) 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] 外科医からみた超偏極・代謝 MRI イメージング:ユーザーの視点から2022

    • Author(s)
      大嶋野歩
    • Organizer
      日本磁気共鳴医学会:スタディグループミーティング「臨床応用を指向する超偏極・代謝 MRIイメージング」
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-time monitoring of pyruvate metabolic fluxes in vivo and targeting intra-tumor metabolic plasticity with small molecules2022

    • Author(s)
      Nobu Oshima, Yuki Aisu, Ryo Ishida, Shun kishimoto, Shigeo Hisamori, Shigeru Tsunoda, Satoshi Kaihara, Kazutaka Obama, Murali C. Krishna, Len Neckers
    • Organizer
      American College of Surgeons, Clinical Congress 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] 消化器癌でのピルビン酸代謝モニタリングと治療応用2022

    • Author(s)
      愛須佑樹, 大嶋野歩, 花田圭太, 岡田倫明, 板谷喜朗, 久森重夫, 角田茂, 河田健二, 兵藤文紀, 松尾政之, 小濱和貴
    • Organizer
      第77回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] 進行再発大腸癌に対する集学的アプローチの最先端 超偏極13C-MRIによる、大腸癌腫瘍内における代謝反応の動的な可視化2021

    • Author(s)
      大嶋 野歩, 兵藤 文紀, 松尾 政之, 角田 茂, 久森 重夫, 板谷 喜郎, 岡田 倫明, 小林 裕之, 橋田 裕毅, 瓜生原 健嗣, 近藤 正人, 北村 好史, 喜多 亮介, 貝原 聡, 小濱 和貴
    • Organizer
      第121回 日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] 食道癌におけるこだわりの手術手技 臓器鞘コンセプトに基づくロボット支援胸腔鏡下上縦隔リンパ節郭清2021

    • Author(s)
      角田 茂, 久森 重夫, 錦織 達人, 岡村 亮輔, 前川 久継, 大森 敦仁, 板谷 喜朗, 岡田 倫明, 大嶋 野歩, 肥田 侯矢, 河田 健二, 喜安 佳之, 山本 高正, 星野 伸明, 村上 克宏, 樽本 浩司, 小濱 和貴
    • Organizer
      第121回 日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] Monitoring of pyruvate metabolism in tumors: application of 13C-MRSI to a novel treatment of targeting cancer metabolism2021

    • Author(s)
      Nobu Oshima, Hiroki Hashida, Shigeo Hisamori, Shigeru Tsunoda, Kazutaka Obama2, Krishna MC, Neckers LM
    • Organizer
      The 80th Annual Meeting of the Japanese Cancer Association
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] 超偏極13C-MRI用いた,薬剤による腫瘍組織内におけるピルビン酸代謝 変容のモニタリング2021

    • Author(s)
      大嶋野歩, 石田諒, 愛須佑樹, 久森重夫, 板谷喜郎, 兵藤文紀, 松尾政之, 角田茂, 貝原聡, 小濱和貴
    • Organizer
      第76回 日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] 胃癌におけるピルビン酸代謝のモニタリングと代謝阻害療法の開発2021

    • Author(s)
      愛須 佑樹, 大嶋 野歩, 花田 圭太, 岡田 倫明, 板谷 喜朗, 久森 重夫, 角田 茂, 兵藤 文紀, 松尾 政之, 小濱 和貴
    • Organizer
      第76回 日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] Monitoring of a novel LDH inhibitor and mitochondrial inhibitor efficacy in vivo in a glycolytic pancreatic cancer model using hyperpolarized13C MRI2020

    • Author(s)
      Nobu Oshima, Ryo Ishida, Shun Kishimoto, Jeffrey R. Brender, Tomoaki Okada, Kazuataka Obama, Yoshiharu Sakai, Murali C. Krishna and Leonard M. Neckers
    • Organizer
      AACR Annual Meeting 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes γ-Glutamyl Transferase Activities in vivo Tumor Xenografts2020

    • Author(s)
      T. Seki, K. Yamamoto, N. Oshima, M. Itoda, Y. Kondo, Y. Saito, Y. Takakusagi, S. Kishimoto, JR Brender, RM Malinowski, JH A-Larsen, H. Nonaka, MC Krishna, S Sando
    • Organizer
      ISMRM & SMRT Virtual Conference 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] 超偏極13C-MRIを用いた,LDH阻害剤およびメトホルミンの大腸癌組織内薬剤効果の可視化と癌治療への応用2020

    • Author(s)
      大嶋野歩, 岡田 倫明, 板谷 喜朗, 出口 靖記, 肥田 侯矢, 河田 健二, Murali Krishna, Leonard Neckers, 小濱 和貴, 坂井義治
    • Organizer
      第75回日本消化器外科学会
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] MRIを用いた大腸癌におけるセラノスティクスー超偏極13C-MRIを用いた腫瘍内における代謝阻害剤効果のDynamic Monitoring~2020

    • Author(s)
      大嶋 野歩, 小濱 和貴, 河田 健二, 肥田 候矢, 久森 重夫, 出口 靖記, 板谷 喜郎, 水野 礼, 和田 聡朗, 錦織 達人, 奥知 慶久, 岡田 倫明, 我如古 理規, Krishna Murali, Neckers Leonard, 坂井 義治
    • Organizer
      第120回日本外科学会
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] Real-time Monitoring of in vivo free radical scavengers through hyperpolarized [1-13C] N-acetyl cysteine2020

    • Author(s)
      K. Yamamoto, A. Opina, K. Saito, RM Malinowski, T. Seki, N. Oshima, D. Sail, JR Brender, S Kishimoto, N Deva, JH A-Larsen, JB Mitchell, RE Swenson, MC Krishna
    • Organizer
      ISMRM & SMRT Virtual Conference 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09054
  • [Presentation] microRNA-137/DCLK1 axis: A novel mechanism regulating tumorigenicity of colon cancer stem cell2016

    • Author(s)
      Masazumi Sakaguchi, Shigeo Hisamori, Nobu Oshima, Yoshiharu Sakai
    • Organizer
      AACR Annual Meeting 2016
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      2016-04-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10139
  • [Presentation] 大腸癌幹細胞におけるmiR-137/DCLK1 axisの重要性2016

    • Author(s)
      坂口正純、久森 重夫、大嶋 野歩、坂井 義治
    • Organizer
      第14回日本臨床腫瘍学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2016-07-28
    • Data Source
      KAKENHI-PROJECT-15K10139
  • [Presentation] Application of iPS Technology to Cancer Stem Cell Research: Generation of Induced Cancer Stem Cells from Colon Cancer Cells by Introducing OCT3/4, SOX2 and KLF42015

    • Author(s)
      Oshima N, Yamada Y, Sakai Y, Aoi T
    • Organizer
      ISSCR 2015 Annual Meeting
    • Place of Presentation
      Stockholm
    • Year and Date
      2015-06-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10139
  • 1.  久森 重夫 (50534351)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 2.  兵藤 文紀 (10380693)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 3.  AOI Takashi (00546997)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  坂井 義治 (60273455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  板谷 喜朗 (80814029)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 6.  高草木 洋一 (60439916)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  齋藤 雄太朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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