Fujihara Yoshitaka 藤原祥高

… Alternative Names

FUJIHARA Yoshitaka 藤原祥高

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Researcher Number	70578848
Other IDs	https://orcid.org/0000-0001-8332-3507
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人国立循環器病研究センター, 研究所, 部長 2019 – 2021: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2018: 大阪大学, 微生物病研究所, 招へい准教授 2013 – 2017: 大阪大学, 微生物病研究所, 助教 2012: 大阪大学, 微生物病研究所, 特任研究員(常勤) 2010 – 2011: 大阪大学, 微生物病研究所, 特任研究員
Review Section/Research Field	Principal Investigator Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Laboratory animal science / Laboratory animal science / Basic Section 42040:Laboratory animal science-related Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 42030:Animal life science-related / Functional biochemistry / Biological Sciences / Laboratory animal science
Keywords	Principal Investigator 受精 / ゲノム編集 / 遺伝子組換えマウス / 進化 / 小分子化合物 / 哺乳類精子 / 雄性不妊 / 精子膜タンパク質 / CRISPR/Casシステム / ES細胞 … More / 点変異 / CRISPR/Cas9 / 精子受精能 / GPIアンカータンパク質 / 雄性生殖 / CRISPR-Cas9 / 子宮-卵管移行 / 受精障害 / 精子診断マーカー / 診断マーカー / 精子受精能力 / 遺伝子組換え動物 / 生物種間保存 / 機能補完 / 遺伝子保存 / 種特異性 / 受精膜融合 / 透明帯通過 / DNAエンコードライブラリー / 避妊薬 / ゲノム編集マウス / 男性避妊薬 / リコンビナントタンパク質 / ノックイン / マウスES細胞 / CRISPR/Cas9システム / CRISPR/cas9 / 哺乳類生殖細胞 / 生殖細胞 / 遺伝子改変マウス / 精子 / 雄性生殖細胞 / ノックアウトマウス / SPACA1タンパク質 / 巨大円形精子症 / 精子形成 … More Except Principal Investigator 男性不妊 / 精子形成 / 遺伝子組換え / 人工制限酵素 / 不妊 / ノックアウト / 実験動物 / CRISPR/Cas / CRISPR/Cas9 / ノックイン / 点変異 / 遺伝子破壊 / 生殖不全 / ゲノム編集 / 環境要因 / 遺伝的要因 / ヒト疾患モデル動物 / 特発性造精機能障害 / セミノリピッド / 密着結合 / 合胞体 / 減数分裂 / 細胞極性 / 精子形成不全 / セミノリピド / 細胞間架橋 / 血液精巣関門 / 精子幹細胞ニッシェ / CRISPR/CAS9 / ノックアウトマウス / 細胞外マトリックス / 生殖 / 卵子 / 精子 / 胎盤 / 卵子機能 / 精子機能 / 受精 / 男性避妊薬 / ES細胞 Less

Comprehensive Analysis of Evolutionarily Conserved Genes Vital for Mammalian Reproduction using Genetically Modified AnimalsPrincipal Investigator
- Principal Investigator
  
  藤原祥高
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  National Cardiovascular Center Research Institute
遺伝的要因・環境要因の組み合わせ最適化による特発性造精機能障害モデルマウスの開発
- Principal Investigator
  
  高島誠司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Shinshu University
Novel roles of seminolipid in the mouse testis
- Principal Investigator
  
  高島誠司
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Shinshu University
Elucidating the universality and specificity of reproductive mechanisms between species using genetically modified animalsPrincipal Investigator
- Principal Investigator
  
  FUJIHARA YOSHITAKA
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  National Cardiovascular Center Research Institute
Development of new diagnostic markers and reversible fertility inhibitors for mammalian spermatozoaPrincipal Investigator
- Principal Investigator
  
  Fujihara Yoshitaka
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  National Cardiovascular Center Research Institute
Elucidating the molecular mechanisms of fertilization common to vertebrate animal modelsPrincipal Investigator
- Principal Investigator
  
  FUJIHARA YOSHITAKA
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  National Cardiovascular Center Research Institute
Developing male contraceptives targeting sperm membrane proteins using the DEC-Tec library(Fostering Joint International Research)Principal Investigator
- Principal Investigator
  
  Fujihara Yoshitaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Laboratory animal science
- Research Institution
  National Cardiovascular Center Research Institute
  Osaka University
Analysis of mammalian germ cell-specific GPI-anchored proteins using genetically modified animalsPrincipal Investigator
- Principal Investigator
  
  Fujihara Yoshitaka
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
Development of method for CRISPR/Cas9 mediated genome editing in micePrincipal Investigator
- Principal Investigator
  
  Fujihara Yoshitaka
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
Analysis of extracellular matrices that regulate mammalian reproduction
- Principal Investigator
  
  Kiyozumi Daiji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Application of CRISPR/Cas9 system for gene manipulation in mice
- Principal Investigator
  
  IKAWA MASAHITO
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
Functional analysis of fertilization related genes in mice
- Principal Investigator
  
  IKAWA MASAHITO
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Analysis of male germ cell specific GPI-anchored proteins using gene-manipulated micePrincipal Investigator
- Principal Investigator
  
  FUJIHARA Yoshitaka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
Analysis of the molecular mechanism of sperm head formation using gene-manipulated animalsPrincipal Investigator
- Principal Investigator
  
  FUJIHARA Yoshitaka
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University

[Book] 「精子と透明帯の相互作用」、細胞工学2014年4月号2014
- Author(s)
  藤原祥高、伊川正人
- Total Pages
  476
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-24700430
[Book] 「マウスにおけるCRISPR/Cas9を用いた遺伝子改変」、実験医学別冊　最強のステップUPシリーズ　今すぐ始めるゲノム編集2014
- Author(s)
  藤原祥高、伊川正人
- Total Pages
  205
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24700430
[Book] 「疾患モデルマウス:臓器系:生殖細胞」、『疾患モデルマウス表現型解析指南』2011
- Author(s)
  藤原祥高、伊川正人
- Publisher
  株式会社中山書店
- Data Source
  KAKENHI-PROJECT-22800041
[Book] ノックアウトマウスプロジェクト」、『モデル動物利用マニュアル<生物機能モデルと新しいリソース・リサーチツール>』2011
- Author(s)
 森岡裕香、藤原祥高、伊川正人
- Publisher
 株式会社エル・アイ・シー
- Data Source
 KAKENHI-PROJECT-22800041
[Journal Article] Tex46 knockout male mice are sterile secondary to sperm head malformations and failure to penetrate through the zona pellucida2024
- Author(s)
  Fujihara Y、Miyata H、Abbasi F、Larasati T、Nozawa K、Yu Z、Ikawa M、Matzuk MM.
- Journal Title
  
  PNAS Nexus
  
  Volume: 3 Issue: 3 Pages: 108-108
- DOI
  10.1093/pnasnexus/pgae108
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0155, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-21H02397
[Journal Article] Testis-enriched ferlin, FER1L5, is required for Ca 2+ -activated acrosome reaction and male fertility2023
- Author(s)
 Morohoshi Akane、Miyata Haruhiko、Tokuhiro Keizo、Iida-Norita Rie、Noda Taichi、Fujihara Yoshitaka、Ikawa Masahito
- Journal Title
 
 Science Advances
 
 Volume: 9 Issue: 4
- DOI
 10.1126/sciadv.ade7607
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-20K06476, KAKENHI-PROJECT-21K19569, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-20H03172, KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-23K24473, KAKENHI-PROJECT-20KK0155, KAKENHI-PROJECT-21H02397
[Journal Article] PDCL2 is essential for sperm acrosome formation and male fertility in mice2022
- Author(s)
  Fujihara Y、Kobayashi K、Abbasi F、Endo T、Yu Z、Ikawa M、Matzuk MM.
- Journal Title
  
  Andrology
  
  Volume: - Issue: 5 Pages: 789-798
- DOI
  10.1111/andr.13329
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0155, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-21H02397, KAKENHI-PROJECT-21K19198, KAKENHI-PLANNED-19H05750
[Journal Article] The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice2022
- Author(s)
  Nozawa K、Fujihara Y、Devlin DJ、Deras RE、Kent K、Larina IV、Umezu K、Yu Z、Sutton CM、Ye Q、Dean LK、Emori C、Ikawa M、Garcia TX、Matzuk MM.
- Journal Title
  
  BMC Biology
  
  Volume: 20 Issue: 1 Pages: 161-161
- DOI
  10.1186/s12915-022-01368-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0155, KAKENHI-PROJECT-21H02397, KAKENHI-PROJECT-21K19198
[Journal Article] Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish2022
- Author(s)
  Noda Taichi、Blaha Andreas、Fujihara Yoshitaka、Gert Krista R.、Emori Chihiro、Deneke Victoria E.、Oura Seiya、Panser Karin、Lu Yonggang、Berent Sara、Kodani Mayo、Cabrera-Quio Luis Enrique、Pauli Andrea、Ikawa Masahito
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 1-11
- DOI
  10.1038/s42003-022-03289-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735, KAKENHI-PROJECT-22K15103, KAKENHI-PROJECT-20KK0155, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-20H03172, KAKENHI-PROJECT-21H02397, KAKENHI-PROJECT-21K19198, KAKENHI-PLANNED-19H05750
[Journal Article] Advancing ASMS with LC‐MS/MS for the discovery of novel PDCL2 ligands from DNA‐encoded chemical library selections2022
- Author(s)
  Ye Q、Belabed H、Wang Y、Yu Z、Palaniappan M、Li JY、Kalovidouris SA、MacKenzie KR、Teng M、Young DW、Fujihara Y、Matzuk MM.
- Journal Title
  
  Andrology
  
  Volume: - Issue: 5 Pages: 808-815
- DOI
  10.1111/andr.13309
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0155, KAKENHI-PROJECT-21H02397, KAKENHI-PROJECT-21K19198
[Journal Article] CRISPR/Cas9‐mediated disruption of lipocalins , Ly6g5b , and Ly6g5c causes male subfertility in mice2022
- Author(s)
 Sakurai N、Fujihara Y、Kobayashi K、Ikawa M.
- Journal Title
 
 Andrology
 
 Volume: - Issue: 5 Pages: 981-990
- DOI
 10.1111/andr.13350
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-20KK0155, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-21H02397, KAKENHI-PROJECT-21K19198, KAKENHI-PLANNED-19H05750
[Journal Article] CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice2022
- Author(s)
  Oyama Yuki、Miyata Haruhiko、Shimada Keisuke、Fujihara Yoshitaka、Tokuhiro Keizo、Garcia ThomasX、Matzuk MartinM、Ikawa Masahito
- Journal Title
  
  Asian Journal of Andrology
  
  Volume: in press Issue: 3 Pages: 0-0
- DOI
  10.4103/aja.aja_63_21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-21H04753, KAKENHI-PROJECT-21H02397, KAKENHI-PROJECT-20K06476, KAKENHI-PROJECT-21K19198, KAKENHI-PROJECT-20K16107, KAKENHI-PROJECT-20KK0155
[Journal Article] TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility2022
- Author(s)
  Oyama Yuki、Miyata Haruhiko、Shimada Keisuke、Larasati Tamara、Fujihara Yoshitaka、Ikawa Masahito
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 21 Issue: 1 Pages: 1-8
- DOI
  10.1002/rmb2.12467
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19569, KAKENHI-PROJECT-20KK0155, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-21H02397, KAKENHI-PROJECT-21K19198, KAKENHI-PROJECT-20K16107, KAKENHI-PLANNED-19H05750
[Journal Article] 疾患モデル動物を用いた循環器病研究の最前線2021
- Author(s)
  藤原祥高、望月直樹
- Journal Title
  
  国立医療学会誌「医療」
  
  Volume: 75 Pages: 111-116
- NAID
  40022558140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02397
[Journal Article] The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization2021
- Author(s)
  Fujihara Yoshitaka、Herberg Sarah、Blaha Andreas、Panser Karin、Kobayashi Kiyonori、Larasati Tamara、Novatchkova Maria、Theussl Hans-Christian、Olszanska Olga、Ikawa Masahito、Pauli Andrea
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 39
- DOI
  10.1073/pnas.2108777118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-21H04753, KAKENHI-PROJECT-21H02397, KAKENHI-PROJECT-21K19198, KAKENHI-PROJECT-20KK0155
[Journal Article] Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression2021
- Author(s)
  Ito J, Minemura T, Walchli S, Niimi T, Fujihara Y, Kuroda S, Takimoto K, Maturana AD.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 22 Issue: 7 Pages: 3561-3561
- DOI
  10.3390/ijms22073561
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02397
[Journal Article] ゲノム編集技術を応用した精子受精能力の制御メカニズムの解明2021
- Author(s)
  藤原祥高
- Journal Title
  
  ゲノム編集技術を応用した製品開発とその実用化
  
  Volume: 1 Pages: 489-495
- Data Source
  KAKENHI-PROJECT-20KK0155
[Journal Article] Tmprss12 is required for sperm motility and uterotubal junction migration in mice2020
- Author(s)
  §Larasati T., §Noda T., Fujihara Y., Shimada K., Tobita T., Yu Z., Matzuk M.M., Ikawa M.
- Journal Title
  
  Biology of Reproduction
  
  Volume: - Issue: 2 Pages: 254-263
- DOI
  10.1093/biolre/ioaa060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14612, KAKENHI-PROJECT-16KK0180, KAKENHI-PROJECT-20K16107, KAKENHI-PROJECT-20KK0155, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-20H03172
[Journal Article] 遺伝子改変技術を用いた疾患モデル動物開発法の進歩と循環器病研究への貢献2020
- Author(s)
  藤原祥高
- Journal Title
  
  循環器病研究の進歩
  
  Volume: 41 Pages: 67-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0155
[Journal Article] Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice2020
- Author(s)
  Fujihara Yoshitaka、Lu Yonggang、Noda Taichi、Oji Asami、Larasati Tamara、Kojima-Kita Kanako、Yu Zhifeng、Matzuk Ryan M.、Matzuk Martin M.、Ikawa Masahito
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 17 Pages: 9393-9400
- DOI
  10.1073/pnas.1917060117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-18K14612, KAKENHI-PROJECT-16KK0180, KAKENHI-PROJECT-18K16735, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394
[Journal Article] Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm－oocyte fusion in mice2020
- Author(s)
  Taichi Noda, Yonggang Lu, Yoshitaka Fujihara, View ORCID ProfileSeiya Oura, View ORCID ProfileTakayuki Koyano, Sumire Kobayashi, Martin M. Matzuk, and View ORCID ProfileMasahito Ikawa
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 21 Pages: 11493-11502
- DOI
  10.1073/pnas.1922650117
- NAID
  120006957465
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-18K14612, KAKENHI-PROJECT-16KK0180, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-19J21619
[Journal Article] Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets2020
- Author(s)
  Robertson MJ, Kent K, Tharp N, Nozawa K, Dean L, Mathew M, Grimm SL, Yu Z, Legare C, Fujihara Y, Ikawa M, Sullivan R, Coarfa C, Matzuk MM, Garcia TX.
- Journal Title
  
  BMC Biology
  
  Volume: 18 Issue: 1 Pages: 103-103
- DOI
  10.1186/s12915-020-00826-z
- NAID
  120006957462
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0155
[Journal Article] CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity2020
- Author(s)
  Park Soojin、Shimada Keisuke、Fujihara Yoshitaka、Xu Zoulan、Shimada Kentaro、Larasati Tamara、Pratiwi Putri、Matzuk Ryan M、Devlin Darius J、Yu Zhifeng、Garcia Thomas X、Matzuk Martin M、Ikawa Masahito
- Journal Title
  
  Biology of Reproduction
  
  Volume: 103 Issue: 2 Pages: 195-204
- DOI
  10.1093/biolre/ioaa084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16107, KAKENHI-PROJECT-20KK0155, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-20J10363
[Journal Article] Seminal vesicle secretory protein 7, PATE4, is not required for sperm function but for copulatory plug formation to ensure fecundity.2019
- Author(s)
  Noda T, Fujihara Y, Matsumura T, Oura S, Kobayashi S, Ikawa M.
- Journal Title
  
  Biology of reproduction
  
  Volume: 印刷中 Issue: 4 Pages: 1035-1045
- DOI
  10.1093/biolre/ioy247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-17J09669, KAKENHI-PROJECT-18K14612
[Journal Article] Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice2019
- Author(s)
  Fujihara Yoshitaka、Noda Taichi、Kobayashi Kiyonori、Oji Asami、Kobayashi Sumire、Matsumura Takafumi、Larasati Tamara、Oura Seiya、Kojima-Kita Kanako、Yu Zhifeng、Matzuk Martin M.、Ikawa Masahito
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 37 Pages: 18498-18506
- DOI
  10.1073/pnas.1908736116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-18K14612, KAKENHI-PROJECT-16KK0180
[Journal Article] CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†2019
- Author(s)
  Yonggang Lu, Oura Seiya, Matsumura Takafumi, et al.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 101 Issue: 2 Pages: 501-511
- DOI
  10.1093/biolre/ioz103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735, KAKENHI-PUBLICLY-18H04885, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-17H04987, KAKENHI-PROJECT-19J00865, KAKENHI-PROJECT-17K17852, KAKENHI-PROJECT-18K14612, KAKENHI-PROJECT-18K14715, KAKENHI-PROJECT-16KK0180
[Journal Article] mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.2018
- Author(s)
  S. Sakamoto, D. Thumkeo, H. Ohta, Z. Zhang, S.R. Huang, P. Kanchenawong, T. Fuu, S. Watanabe, K. Shimada, Y. Fujihara, S. Yoshida, M. Ikawa, N. Watanabe, M. Saitou and S. Narumiya
- Journal Title
  
  Plos Biology
  
  Volume: 16 Issue: 9 Pages: e2004874-e2004874
- DOI
  10.1371/journal.pbio.2004874
- NAID
  120006531249
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05551, KAKENHI-PROJECT-16H02507, KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-17H06098, KAKENHI-PROJECT-17K08591
[Journal Article] Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a2018
- Author(s)
  Higa M, Oka M, Fujihara Y, Masuda K, Yoneda Y, Kishimoto T.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 6:115(6) Issue: 6
- DOI
  10.1073/pnas.1719921115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25116008, KAKENHI-PROJECT-16K14676, KAKENHI-PROJECT-16H04789, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-17H03679
[Journal Article] Factors controlling sperm migration through the oviduct revealed by gene-modified mouse models2018
- Author(s)
  fujihara Y, Miyata H, Ikawa M.
- Journal Title
  
  Exp. Anim.
  
  Volume: 67 Issue: 2 Pages: 91-104
- DOI
  10.1538/expanim.17-0153
- NAID
  130006733631
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-17H04987, KAKENHI-PROJECT-15H05573
[Journal Article] Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease2018
- Author(s)
  Kurahara Lin Hai、Hiraishi Keizo、Hu Yaopeng、Koga Kaori、Onitsuka Miki、Doi Mayumi、Aoyagi Kunihiko、Takedatsu Hidetoshi、Kojima Daibo、Fujihara Yoshitaka、Jian Yuwen、Inoue Ryuji
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 5 Issue: 3 Pages: 299-318
- DOI
  10.1016/j.jcmgh.2017.12.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15566, KAKENHI-PROJECT-15H04678, KAKENHI-PROJECT-15K08978, KAKENHI-PROJECT-15H05573
[Journal Article] Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice.2018
- Author(s)
  Fujihara Y, Oji A, Kojima-Kita K, Larasati T, Ikawa M.
- Journal Title
  
  Journal of cell science
  
  Volume: 131 Pages: 221481-221481
- DOI
  10.1242/jcs.221481
- NAID
  130007719285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-15H05573
[Journal Article] MARCKSL1 regulates spine formation in the amygdala and controls the hypothalamic-pituitary-adrenal axis and anxiety-like behaviors.2018
- Author(s)
  Tanaka T, Shimizu S, Ueno M, Fujihara Y, Ikawa M, Miyata S.
- Journal Title
  
  EBioMedicine
  
  Volume: 30 Pages: 62-73
- DOI
  10.1016/j.ebiom.2018.03.018
- NAID
  120006957428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19443, KAKENHI-PUBLICLY-17H05556, KAKENHI-WRAPUP-18H05199, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-17H04985, KAKENHI-PROJECT-16K07073
[Journal Article] Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models2017
- Author(s)
  Fujihara Yoshitaka、Oji Asami、Larasati Tamara、Kojima-Kita Kanako、Ikawa Masahito
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 18 Issue: 10 Pages: 2208-2208
- DOI
  10.3390/ijms18102208
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-16H06276
[Journal Article] JunB is essential for IL-23-dependent pathogenicity of Th17 cells.2017
- Author(s)
  Hasan Z, Koizumi SI, Sasaki D, Yamada H, Arakaki N, Fujihara Y, Okitsu S, Shirahata H, Ishikawa H.
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 15628-15628
- DOI
  10.1038/ncomms15628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-16H06866
[Journal Article] A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling.2017
- Author(s)
  Fujitani, M., Zhang, S., Fujiki, R., Fujihara, Y. and Yamashita, T.
- Journal Title
  
  Mol. Psychiatry
  
  Volume: 22 Issue: 3 Pages: 364-374
- DOI
  10.1038/mp.2016.106
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221309, KAKENHI-PROJECT-26462206, KAKENHI-PROJECT-15H05573
[Journal Article] A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.2016
- Author(s)
  Lee GH, Fujita M, Takaoka K, Murakami Y, Fujihara Y, Kanzawa N, Murakami KI, Kajikawa E, Takada Y, Saito K, Ikawa M, Hamada H, Maeda Y, Kinoshita T.
- Journal Title
  
  J Cell Biol
  
  Volume: 215 Issue: 5 Pages: 705-718
- DOI
  10.1083/jcb.201605121
- NAID
  120006957406
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15K08303, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-25112001
[Journal Article] 生殖不全の表現型解析2016
- Author(s)
  藤原祥高，佐藤裕公，伊川正人
- Journal Title
  
  実験医学別冊マウス表現型解析スタンダード
  
  Volume: 1 Pages: 216-227
- Data Source
  KAKENHI-PROJECT-15H05573
[Journal Article] The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and it is essential for reproduction2016
- Author(s)
  Daisuke Yamazaki, Haruhiko Miyata, Yosuke Funato, Yoshitaka Fujihara, Masahito Ikawa, Hiroaki Miki
- Journal Title
  
  Journal of Cell Science
  
  Volume: 未定 Issue: 9 Pages: 1940-1949
- DOI
  10.1242/jcs.182220
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430113, KAKENHI-PROJECT-26460364, KAKENHI-PLANNED-26111007, KAKENHI-PROJECT-26291042, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-16K14723, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-25112001
[Journal Article] Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.2016
- Author(s)
  Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, Ikawa M, Nureki O.
- Journal Title
  
  Nat Commun.
  
  Volume: 7 Issue: 1 Pages: 12198-12198
- DOI
  10.1038/ncomms12059
- NAID
  120006957420
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-16H06148, KAKENHI-PROJECT-25461659, KAKENHI-PROJECT-15K08280, KAKENHI-PROJECT-16K10119, KAKENHI-PROJECT-16K11075, KAKENHI-PROJECT-16K15238, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-16K15239, KAKENHI-PROJECT-26250027
[Journal Article] A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.2016
- Author(s)
  Lee GH, Fujita M, Takaoka K, Murakami Y, Fujihara Y, Kanzawa N, Murakami KI, Kajikawa E, Takada Y, Saito K, Ikawa M, Hamada H, Maeda Y, Kinoshita T.
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 215 Pages: 705-718
- NAID
  120006957406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05573
[Journal Article] Live imaging of X chromosome reactivation dynamics in early mouse development can discriminate naive from primed pluripotent stem cells.2016
- Author(s)
  Kobayashi S, Hosoi Y, Shiura H, Yamagata K, Takahashi S, Fujihara Y, Kohda T, Okabe M, Ishino F.
- Journal Title
  
  Development
  
  Volume: 143 Issue: 16 Pages: 2958-2964
- DOI
  10.1242/dev.136739
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-25712035, KAKENHI-PROJECT-15K18456, KAKENHI-PROJECT-26430087, KAKENHI-PUBLICLY-15H01468
[Journal Article] Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.2016
- Author(s)
  Miyata H, Castaneda JM, Fujihara Y, Yu Z, Archambeault DR, Isotani A, Kiyozumi D, Kriseman ML, Mashiko D, Matsumura T, Matzuk RM, Mori M, Noda T, Oji A, Okabe M, Prunskaite-Hyyrylainen R, Ramirez-Solis R, Satouh Y, Zhang Q, Ikawa M, Matzuk MM.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113 Issue: 28 Pages: 7704-7710
- DOI
  10.1073/pnas.1608458113
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15J04519, KAKENHI-PROJECT-16K15687, KAKENHI-PROJECT-15K18387, KAKENHI-PROJECT-26830056, KAKENHI-PROJECT-15K06999, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-25112001
[Journal Article] CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice.2016
- Author(s)
  Oji A, Noda T, Fujihara Y, Miyata H, Kim YJ, Muto M, Nozawa K, Matsumura T, Isotani A, Ikawa M.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 34666-34666
- DOI
  10.1038/srep31666
- NAID
  120006957419
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15J04519, KAKENHI-PROJECT-16J04613, KAKENHI-PROJECT-26830056, KAKENHI-ORGANIZER-25112001
[Journal Article] Lentiviral Vector Mediated Complementation Restored Fetal Viability but Not Placental hyperplasia in Plac1-Deficient Mice.2016
- Author(s)
  Muto M, Fujihara Y, Tobita T, Kiyozumi D, Ikawa M.
- Journal Title
  
  Biol Reprod.
  
  Volume: 94(1) Issue: 1 Pages: 6-6
- DOI
  10.1095/biolreprod.115.133454
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15K14366, KAKENHI-PROJECT-15K15607
[Journal Article] GPI-AP release in cellular, developmental, and reproductive biology.2016
- Author(s)
  Fujihara Y, Ikawa M.
- Journal Title
  
  J Lipid Res.
  
  Volume: 57 Issue: 4 Pages: 538-545
- DOI
  10.1194/jlr.r063032
- NAID
  120006957424
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-25112001
[Journal Article] Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.2016
- Author(s)
  Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, Ikawa M, Nureki O.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 12198-12198
- DOI
  10.1038/ncomms12198
- NAID
  120006957420
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15J04519, KAKENHI-PROJECT-15J08403, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-16H06294
[Journal Article] マウス個体でのゲノム編集（2）簡便かつ迅速な遺伝子改変マウス作製法について2015
- Author(s)
  藤原祥高、伊川正人
- Journal Title
  
  医学のあゆみ
  
  Volume: 252 Pages: 165-169
- Open Access
- Data Source
  KAKENHI-PROJECT-24700430
[Journal Article] Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes.2015
- Author(s)
  Ono R., Ishii M., Fujihara Y., Kitazawa M., Usami T., Kaneko-Ishino T., Kanno J., Ikawa M., Ishino F.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 12281-12281
- DOI
  10.1038/srep12281
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430183, KAKENHI-PUBLICLY-15H01468, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-26113706, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15K14366, KAKENHI-PROJECT-23221010
[Journal Article] 第II部第3章　マウスでのゲノム編集2015
- Author(s)
  藤原祥高、伊川正人
- Journal Title
  
  ゲノム編集成功の秘訣Q＆A
  
  Volume: 1 Pages: 106-123
- Data Source
  KAKENHI-PROJECT-15H05573
[Journal Article] Induction of DNA Methylation by Artificial piRNA Production in Male Germ Cells2015
- Author(s)
  Itou D, Shiromoto Y, Shin-Ya Y, Ishii C, Nishimura T, Ogonuki N, Ogura A, Hasuwa H, Fujihara Y, Kuramochi-Miyagawa S, Nakano T.
- Journal Title
  
  Current biology
  
  Volume: 25 Issue: 7 Pages: 901-906
- DOI
  10.1016/j.cub.2015.01.060
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24700430, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-26112511, KAKENHI-PROJECT-26430100, KAKENHI-PROJECT-24249018, KAKENHI-PROJECT-24370074
[Journal Article] Calreticulin is required for development of the cumulus oocyte complex and female fertility.2015
- Author(s)
  Tokuhiro K, Satouh Y, Nozawa K, Isotani A, Fujihara Y, Hirashima Y, Matsumura H, Takumi K, Miyano T, Okabe M, Benham AM, Ikawa M.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 14254-14254
- DOI
  10.1038/srep14254
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21737, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15K14366, KAKENHI-PROJECT-26860258, KAKENHI-PROJECT-26292136
[Journal Article] Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive2015
- Author(s)
  Haruhiko Miyata, Yuhkoh Satouh, Daisuke Mashiko, Masanaga Muto, Kaori Nozawa, Kogiku Shiba, Yoshitaka Fujihara, Ayako Isotani, Kazuo Inaba, Masahito Ikawa
- Journal Title
  
  Science
  
  Volume: 350 Issue: 6259 Pages: 442-445
- DOI
  10.1126/science.aad0836
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830056, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15J03876, KAKENHI-PROJECT-15K14366, KAKENHI-PROJECT-26840061
[Journal Article] 第II部第3章　マウスでのゲノム編集2015
- Author(s)
  藤原祥高、伊川正人
- Journal Title
  
  ゲノム編集成功の秘訣Q＆A
  
  Volume: 1 Pages: 106-123
- Data Source
  KAKENHI-PROJECT-15K14366
[Journal Article] CRISPR/Cas9-based genome editing in mice by single plasmid injection2014
- Author(s)
  Fujihara Y, Ikawa M.
- Journal Title
  
  Methods in enzymology
  
  Volume: 546 Pages: 319-336
- DOI
  10.1016/b978-0-12-801185-0.00015-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24700430
[Journal Article] Generation of Precise Point Mutation Mice by Footprintless Genome Modification.2014
- Author(s)
  Morioka, Y., Fujihara, Y., and Okabe, M.
- Journal Title
  
  Genesis
  
  Volume: 52 Issue: 1 Pages: 68-77
- DOI
  10.1002/dvg.22727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24700430, KAKENHI-PUBLICLY-25127709
[Journal Article] Ftx is dispensable for imprinted X-chromosome inactivation in preimplantation mouse embryos.2014
- Author(s)
  Soma, M., Fujihara, Y., Okabe, M., Ishino, F. and Kobayashi, S.
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 5181-5181
- DOI
  10.1038/srep05181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221010, KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24700430, KAKENHI-PROJECT-26430087
[Journal Article] Feasibility for a large scale mouse mutagenesis by injecting CRISPR/Cas plasmid into zygotes2014
- Author(s)
  Mashiko D, Young SA, Muto M, Kato H, Nozawa K, Ogawa M, Noda T, Kim YJ, Satouh Y, Fujihara Y, Ikawa M.
- Journal Title
  
  Development, Growth & Differentiation
  
  Volume: 56 Issue: 1 Pages: 122-129
- DOI
  10.1111/dgd.12113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700430, KAKENHI-PROJECT-24770210, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PUBLICLY-25113714, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-25890013
[Journal Article] マウスのゲノム編集がもたらす可能性2014
- Author(s)
  藤原祥高、伊川正人
- Journal Title
  
  実験医学
  
  Volume: 32 Pages: 1709-1714
- Data Source
  KAKENHI-PROJECT-24700430
[Journal Article] GPI-Anchored Protein Complex, LY6K/TEX101, Is Required for Sperm Migration into the Oviduct and Male Fertility in Mice.2014
- Author(s)
  Fujihara, Y., Okabe, M., and Ikawa, M.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 90 Issue: 3 Pages: 1-6
- DOI
  10.1095/biolreprod.113.112888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24700430, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PUBLICLY-25127709
[Journal Article] CRISPR/Cas9-Based Genome Editing in Mice by Single Plasmid Injection2014
- Author(s)
  Fujihara Y, Ikawa M.
- Journal Title
  
  Methods Enzymol
  
  Volume: 546C Pages: 319-336
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-25112007
[Journal Article] Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa2013
- Author(s)
  FujiharaY, Tokuhiro K, Muro Y, Kondoh G, Araki Y, Ikawa M, Okabe M
- Journal Title
  
  PNAS
  
  Volume: 110(20) Issue: 20 Pages: 8111-6
- DOI
  10.1073/pnas.1222166110
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008, KAKENHI-PROJECT-20670006, KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24592609, KAKENHI-PROJECT-24700430, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25462575, KAKENHI-PUBLICLY-23113510
[Journal Article] Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA.2013
- Author(s)
  Mashiko D, Fujihara Y, Satouh Y, Miyata H, Isotani A, Ikawa M.
- Journal Title
  
  Scientific Reports
  
  Volume: 3: 3355 Issue: 1 Pages: 1-6
- DOI
  10.1038/srep03355
- NAID
  120006957396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500490, KAKENHI-PROJECT-24700430, KAKENHI-PROJECT-24770210, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PUBLICLY-25113714, KAKENHI-PROJECT-25250014
[Journal Article] Identification of an imprinted gene cluster in the X-inactivation center.2013
- Author(s)
  Kobayashi S, Totoki Y, Soma M, Matsumoto K, Fujihara Y, Toyoda A, Sakaki Y, Okabe M, Ishino F.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 8 Pages: e71222-e71222
- DOI
  10.1371/journal.pone.0071222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221010, KAKENHI-PROJECT-24700430
[Journal Article] Production of mouse pups from germline transmission-failed knockout chimeras.2012
- Author(s)
  Fujihara Y., et al.
- Journal Title
  
  Transgenic Res
  
  Volume: 22 Issue: 1 Pages: 195-200
- DOI
  10.1007/s11248-012-9635-x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008, KAKENHI-PROJECT-20670006, KAKENHI-PLANNED-21112006, KAKENHI-PROJECT-23500492, KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24700430, KAKENHI-PUBLICLY-23113510
[Journal Article] SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia2012
- Author(s)
  Fujihara Y, Satouh Y, Inoue N, Isotani A, Ikawa M, Okabe M
- Journal Title
  
  Development
  
  Volume: 139 Issue: 19 Pages: 3583-9
- DOI
  10.1242/dev.081778
- NAID
  120006957401
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008, KAKENHI-PROJECT-20670006, KAKENHI-PLANNED-21112006, KAKENHI-PROJECT-23500492, KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24500490, KAKENHI-PROJECT-24700430, KAKENHI-PROJECT-24770210, KAKENHI-PUBLICLY-23113510, KAKENHI-PUBLICLY-23116704
[Journal Article] Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa2012
- Journal Title
  
  Mol Biol Cell
  
  Volume: 23 Issue: 14 Pages: 2671-9
- DOI
  10.1091/mbc.e11-12-1025
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008, KAKENHI-PROJECT-20670006, KAKENHI-PROJECT-23500492, KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24700430, KAKENHI-PUBLICLY-23113510
[Journal Article] The X-linked imprinted gene family Fthl17 shows predominantly female expression following the two-cell stage in mouse embryos.2010
- Author(s)
  小林慎、藤原祥高, 他5名
- Journal Title
  
  Nucleic acids research
  
  Volume: 38(11) Pages: 3672-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22800041
[Journal Article] Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse.2010
- Author(s)
  藤原祥高, 他6名
- Journal Title
  
  Journal of cell science
  
  Volume: 123(Pt9) Pages: 1531-6
- NAID
  120006957390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22800041
[Journal Article] The X-linked imprinted gene family Fthl17 shows predominantly female expression following the two-cell stage in mouse embryos2010
- Author(s)
  Kobayashi S., Fujihara Y., Mise N., Kaseda K., Abe K., Ishino F., Okabe M.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 38号 Issue: 11 Pages: 3672-81
- DOI
  10.1093/nar/gkq113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22800041
[Journal Article] Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse2010
- Author(s)
  Fujihara Y, Murakami M, Inoue N, Satouh Y, Kaseda K, Ikawa M, Okabe M
- Journal Title
  
  J Cell Sci
  
  Volume: 123(Pt 9) Issue: 9 Pages: 1531-1536
- DOI
  10.1242/jcs.067363
- NAID
  120006957390
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21112006, KAKENHI-PROJECT-21687018, KAKENHI-PROJECT-22800041
[Presentation] Molecular mechanisms of mammalian spermatogenesis and fertilization revealed by genome-edited mice2023
- Author(s)
  Yoshitaka Fujihara
- Organizer
  The Fifth Annual David H. Yawn Commemorative Lecture
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0155
[Presentation] Screening male contraceptive targets using CRISPR/Cas9-mediated KO mice2023
- Author(s)
  Yoshitaka Fujihara
- Organizer
  2023 National Contraception Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02397
[Presentation] Molecular mechanism of mammalian fertilization　revealed by genome-edited mice2023
- Author(s)
  Yoshitaka Fujihara
- Organizer
  The Fibrobesity Visitor Program and Kontinkangas Campus Seminar Series 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0155
[Presentation] PDCL2 is essential for sperm acrosome formation and male fertility in mice2023
- Author(s)
  Haga S, Kobayashi K, Abbasi F, Endo T, Yu Z, Ikawa M, Matzuk MM, and Fujihara Y.
- Organizer
  第70回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-20KK0155
[Presentation] Molecular mechanism of mammalian fertilization　revealed by genome-edited mice2023
- Author(s)
  Yoshitaka Fujihara
- Organizer
  The Fibrobesity Visitor Program and Kontinkangas Campus Seminar Series 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02397
[Presentation] PDCL2 is essential for sperm acrosome formation and male fertility in mice2023
- Author(s)
  Yoshitaka Fujihara
- Organizer
  The 22nd European Testis Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0155
[Presentation] PDCL2 is essential for sperm acrosome formation and male fertility in mice2023
- Author(s)
  Yoshitaka Fujihara
- Organizer
  56th Annual Meeting of the Society for the Study of Reproduction (SSR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0155
[Presentation] PDCL2 is essential for sperm acrosome formation and male fertility in mice2023
- Author(s)
  Yoshitaka Fujihara
- Organizer
  The 22nd European Testis Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02397
[Presentation] PDCL2 is essential for sperm acrosome formation and male fertility in mice2023
- Author(s)
  Yoshitaka Fujihara
- Organizer
  56th Annual Meeting of the Society for the Study of Reproduction (SSR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02397
[Presentation] Screening male contraceptive targets using CRISPR/Cas9-mediated KO mice2023
- Author(s)
  Yoshitaka Fujihara
- Organizer
  2023 National Contraception Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0155
[Presentation] Molecular mechanisms of mammalian spermatogenesis and fertilization revealed by genome-edited mice2023
- Author(s)
  Yoshitaka Fujihara
- Organizer
  The Fifth Annual David H. Yawn Commemorative Lecture
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02397
[Presentation] PDCL2 is essential for sperm acrosome formation and male fertility in mice2023
- Author(s)
  Haga S, Kobayashi K, Abbasi F, Endo T, Yu Z, Ikawa M, Matzuk MM, and Fujihara Y.
- Organizer
  第70回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-21H02397
[Presentation] 生殖細胞の異常が引き起こす血液精巣関門の構造と機能の変容.2022
- Author(s)
  則竹康佑, 中野愛里, 古瀬幹夫, 山下竜幸, 本家考一, 小沢学, 伊川正人, 藤原祥高, 岩森督子, 高島誠司.
- Organizer
  第115回日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-21H02379
[Presentation] Seminolipid is required for the integrity of Blood-Testis Barrier in mice.2022
- Author(s)
  Noritake, K., Nakano, A., Furuse, M., Yamashita, T., Honke, K., Ozawa, M., Ikawa, M., Fujihara, Y., Iwamori, T., and Takashima, S.
- Organizer
  The International Symposium “Totipotency and Germ cell Development.”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02379
[Presentation] セミノリピド欠損マウスにおける雌性不妊および胆嚢拡張症解析2021
- Author(s)
  中野愛里, 上村麻実, 金井克晃, 藤原祥高, 岩森督子, 岩森督子, 藤本空, 根岸淳, 保地眞一, 高島誠司, 高島誠司
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02379
[Presentation] 遺伝子改変マウスを用いた精子膜タンパク質FIMPの機能解析2020
- Author(s)
  藤原祥高、Yonggang Lu、野田大地、大字亜沙美、Tamara Larasati、北加奈子、Zhifeng Yu、Ryan M. Matzuk、Martin M. Matzuk、伊川正人
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20KK0155
[Presentation] Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice2019
- Author(s)
  Yoshitaka Fujihara, Asami Oji, Kanako Kita, Tamara Larasati, and Masahito Ikawa
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16KK0180
[Presentation] Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice2019
- Author(s)
  Yoshitaka Fujihara, Asami Oji, Kanako Kita, Tamara Larasati, and Masahito Ikawa
- Organizer
  The 52th SSR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KK0180
[Presentation] 遺伝子改変マウスを用いた精子GPIアンカータンパク質LYPD4の機能解析2019
- Author(s)
  藤原祥高、大字亜沙美、Tamara Larasati、北加奈子、伊川正人
- Organizer
  第66回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-16KK0180
[Presentation] Sperm GPI-anchored protein LYPD4 is required for sperm migration through the oviduct in mice2019
- Author(s)
  Yoshitaka Fujihara, Asami Oji, Tamara Larasati, Kanako Kita, Zhifeng Yu, Martin M. Matzuk and Masahito Ikawa
- Organizer
  NICHD 2019 Contraceptive Development Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KK0180
[Presentation] Analysis of mouse models of male infertility using genetic modification2019
- Author(s)
  Yoshitaka Fujihara
- Organizer
  Oulu University Kontinkangas Campus Seminar Series
- Invited
- Data Source
  KAKENHI-PROJECT-16KK0180
[Presentation] 精子膜タンパク質CMTM2A及びCMTM2Bの共発現がADAM3の局在と精子受精能に必須である2019
- Author(s)
  藤原祥高、大字亜沙美、Tamara Larasati、北加奈子、伊川正人
- Organizer
  第112回日本日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-16KK0180
[Presentation] Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice2019
- Author(s)
  Yoshitaka Fujihara, Asami Oji, Kanako Kita, Tamara Larasati, and Masahito Ikawa
- Organizer
  The XXV North American Testis Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KK0180
[Presentation] ゲノム編集動物作製法の開発と雄性不妊モデルマウスの機能解析2019
- Author(s)
  藤原祥高
- Organizer
  第19回日本生殖工学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] Human globozoospermia-related gene Spata16 is required for sperm formation revealed by CRISPR/Cas9-mediated mouse models2019
- Author(s)
  Yoshitaka Fujihara, Asami Oji, Tamara Larasati, Kanako Kojima-Kita, and Masahito Ikawa
- Organizer
  66th Annual Meeting of the Society for Reproductive Investigation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] Human globozoospermia-related gene Spata16 is required for sperm formation revealed by CRISPR/Cas9-mediated mouse models2018
- Author(s)
  Yoshitaka Fujihara, Asami Oji, Tamara Larasati, Kanako Kojima-Kita, and Masahito Ikawa
- Organizer
  51st Annual Meeting of the Society for the Study of Reproduction
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] 遺伝子改変マウスを用いた精巣特異的Cmtm遺伝子群の機能解析2018
- Author(s)
  藤原祥高、大字亜沙美、北加奈子、Tamara Larasati、伊川正人
- Organizer
  第65回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] 遺伝子改変技術を用いた雄性不妊モデルマウスの開発と機能解析2017
- Author(s)
  藤原祥高
- Organizer
  第64回日本実験動物学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] Human globozoospermia-related gene Spata16 is essential for spermiogenesis in mice2017
- Author(s)
  Yoshitaka Fujihara, Asami Oji, Tamara Larasati, Kanako Kojima-Kita and Masahito Ikawa
- Organizer
  Fourth World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] Generation of point mutant mouse model responsible for human globozoospermia by CRISPR/Cas9 system2017
- Author(s)
  Yoshitaka Fujihara, Asami Oji, Kanako Kita, and Masahito Ikawa
- Organizer
  第64回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] 遺伝子改変マウスを用いた雄性生殖細胞特異的な膜タンパク質の機能解析2017
- Author(s)
  藤原祥高
- Organizer
  奈良先端科学技術大学院大学バイオサイエンス研究科セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] Human globozoospermia-related gene Spata16 is essential for spermiogenesis in mice2017
- Author(s)
  Yoshitaka Fujihara, Asami Oji, Tamara Larasati, Kanako Kojima-Kita and Masahito Ikawa
- Organizer
  2017年度生命科学系学会合同年次大会（第40回日本分子生物学会年会）
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] 遺伝子改変技術を用いた雄性不妊モデルマウスの開発と機能解析2017
- Author(s)
  藤原祥高
- Organizer
  第14回熊本大学生命資源研究・支援センターシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] GPI-anchored protein complex, TEX101 and LY6K, is required for sperm fertilizing ability in mice2016
- Author(s)
  Yoshitaka Fujihara, Masaru Okabe, Masahito Ikawa
- Organizer
  国際シンポジウム "生殖細胞のエピゲノムダイナミクスとその制御"
- Place of Presentation
  京都大学百周年時計台記念館
- Year and Date
  2016-02-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] GPI-anchored protein complex, TEX101 and LY6K, is required for sperm fertilizing ability in mice2016
- Author(s)
  Yoshitaka Fujihara, Masaru Okabe, Masahito Ikawa
- Organizer
  国際シンポジウム "生殖細胞のエピゲノムダイナミクスとその制御"
- Place of Presentation
  京都大学百周年時計台記念館
- Year and Date
  2016-02-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14366
[Presentation] 雄性生殖細胞特異的な発現を示すGPIアンカータンパク質複合体LY6K/TEX101の精子受精能における役割2015
- Author(s)
  藤原祥高、岡部勝、伊川正人
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-15K14366
[Presentation] CRISPR/Casシステムを使った遺伝子改変マウス作製法の開発2015
- Author(s)
  藤原祥高
- Organizer
  第2回阪大微研x慶応先端生命研合同研究会
- Place of Presentation
  大阪大学微生物病研究所
- Year and Date
  2015-03-05
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] GPI-anchored protein complex, LY6K/TEX101, is required for sperm fertilizing ability in mice2015
- Author(s)
  Yoshitaka Fujihara, Masaru Okabe, Masahito Ikawa
- Organizer
  第10回研究所ネットワーク国際シンポジウム
- Place of Presentation
  北海道大学遺伝子病制御研究所
- Year and Date
  2015-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14366
[Presentation] 雄性生殖細胞特異的 GPI アンカータンパク質の機能解析と新規遺伝子改変マウス作製法の開発2015
- Author(s)
  藤原祥高
- Organizer
  神戸大学重点研究チーム「資源動物のシグナル伝達制御に関する研究」ワークショップ「生殖細胞研究の最先端技術」
- Place of Presentation
  神戸大学農学研究科
- Year and Date
  2015-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] 雄性生殖細胞特異的な発現を示すGPIアンカータンパク質複合体LY6K/TEX101の精子受精能における役割2015
- Author(s)
  藤原祥高、岡部勝、伊川正人
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] 雄性生殖細胞特異的 GPI アンカータンパク質の機能解析と新規遺伝子改変マウス作製法の開発2015
- Author(s)
  藤原祥高、伊川正人
- Organizer
  神戸大学重点研究チーム「資源動物のシグナル伝達制御に関する研究」ワークショップ「生殖細胞研究の最先端技術」
- Place of Presentation
  神戸大学農学研究科
- Year and Date
  2015-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-15K14366
[Presentation] GPI-anchored protein complex, LY6K/TEX101, is required for sperm fertilizing ability in mice2015
- Author(s)
  Yoshitaka Fujihara, Masaru Okabe, Masahito Ikawa
- Organizer
  第10回研究所ネットワーク国際シンポジウム
- Place of Presentation
  北海道大学遺伝子病制御研究所
- Year and Date
  2015-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05573
[Presentation] CRISPR/Casシステムを使った遺伝子改変マウス作製2014
- Author(s)
  藤原祥高
- Organizer
  日本実験動物技術者協会関西支部秋季大会
- Place of Presentation
  サテライトキャンパスひろしま
- Year and Date
  2014-11-29
- Invited
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] CRISPR/Cas9環状プラスミドの前核注入による変異マウス作製2014
- Author(s)
  藤原祥高、増子大輔、西岡佐紀、江崎陽子、伊川正人
- Organizer
  第61回日本実験動物学会総会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-05-15
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] ノックアウトマウス作製の効率化を目指したC57BL/6由来ES細胞の樹立とその応用2013
- Author(s)
  藤原祥高
- Organizer
  第60回日本実験動物学会総会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] 精巣内生殖細胞特異的な発現を示すTtex101ノックアウトマウスの作製と機能解析2011
- Author(s)
  藤原祥高
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22800041
[Presentation] 精子形成におけるIZUMO1およびSPACA1タンパク質の局在変化と機能解析2011
- Author(s)
  藤原祥高
- Organizer
  第58回日本実験動物学会総会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-22800041
[Presentation] 精子形成におけるIZUMO1およびSPACA1タンパク質の局在変化と機能解析2011
- Author(s)
  藤原祥高、佐藤裕公、井上直和、磯谷綾子、伊川正人、岡部勝
- Organizer
  第58回日本実験動物学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-22800041
[Presentation] 精巣内生殖細胞特異的な発現を示すTex101ノックアウトマウスの作製と機能解析2011
- Author(s)
  藤原祥高、徳弘圭造、室悠子、荒木慶彦、伊川正人、岡部勝
- Organizer
  第34回日本分生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22800041
[Presentation] Spacal, sperm acrosome associated 1, is required for acrosome formation in mice2010
- Author(s)
  藤原祥高
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22800041
[Presentation] Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse2010
- Author(s)
  藤原祥高
- Organizer
  International Symposium for Immunology of Reproduction joint meeting in conjunction with The 25th Annual Meating of Japan Society for Immunology of Reproduction
- Place of Presentation
  大阪大学銀杏会館(大阪)
- Year and Date
  2010-08-28
- Data Source
  KAKENHI-PROJECT-22800041
[Presentation] Spacal, Sperm acrosome associated 1, is required for sperm-head shaping2010
- Author(s)
  藤原祥高
- Organizer
  11th International Symposium on Spermatology
- Place of Presentation
  沖縄コンベンションセンター(沖縄)
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-22800041
[Presentation] Spaca1, sperm acrosome associated 1, is required for acrosome formation in mice2010
- Author(s)
  藤原祥高、佐藤裕公、井上直和、磯谷綾子、伊川正人、岡部勝
- Organizer
  BMB2010(第33回日本分生物学会年会、第83回日本生化学会大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22800041
[Presentation] Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse2010
- Author(s)
  Y. Fujihara, M. Murakami, N. Inoue, Y. Satouh, K. Kaseda, M. Ikawa, M. Okabe
- Organizer
  International Symposium for Immunology of Reproduction
- Place of Presentation
  Osaka, Japan
- Year and Date
  2010-08-28
- Data Source
  KAKENHI-PROJECT-22800041
[Presentation] Spaca1, Sperm acrosome associated 1, is required for sperm-head shaping2010
- Author(s)
  Y. Fujihara, Y. Satouh, N. Inoue, A. Isotani, M. Ikawa, M. Okabe
- Organizer
  11th International Symposium on Spermatology
- Place of Presentation
  Okinawa, Japan
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-22800041
[Presentation] ノックアウトマウス作製の効率化を目指したC57/BL6由来ES細胞の樹立とその応用
- Author(s)
  藤原祥高
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] マウス精子頭部に局在するSPESP1欠損マウスの作製と機能解析
- Author(s)
  藤原祥高
- Organizer
  第31回日本アンドロロジー学会学術大会
- Place of Presentation
  神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] Germ cell-specific GPI-anchored proteins are required for sperm fertilizing ability in mice
- Author(s)
  Yoshitaka Fujihara
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] 精巣内生殖細胞特異的な発現を示すTex101欠損マウスの機能解析
- Author(s)
  藤原祥高
- Organizer
  第59回日本実験動物学会総会
- Place of Presentation
  別府国際コンベンションセンター
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia
- Author(s)
  Yoshitaka Fujihara
- Organizer
  第8回研究所ネットワーク国際シンポジウム
- Place of Presentation
  京大医学部芝蘭会館
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] 雄性生殖細胞特異的な発現を示すGPIアンカータンパク質の精子受精能における役割
- Author(s)
  藤原祥高
- Organizer
  第45回精子研究会・神戸大学研究重点チーム学術講演会
- Place of Presentation
  神戸大学統合研究拠点コンベンションホール
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] 精巣内生殖細胞特異的な発現を示すTex101欠損マウスの機能解析
- Author(s)
  藤原祥高
- Organizer
  第105回日本繁殖生物学会大会
- Place of Presentation
  筑波大学大学会館
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] TEX101, testis specific GPI-anchored protein, is required for sperm fertility in mice
- Author(s)
  藤原祥高
- Organizer
  特定領域生殖サイクル若手勉強会2012
- Place of Presentation
  秋保リゾートホテルクレセント
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] CRISPR/Casシステムを用いたマウスゲノム編集
- Author(s)
  藤原祥高
- Organizer
  第３回ゲノム編集研究会
- Place of Presentation
  広島大学理学部
- Data Source
  KAKENHI-PROJECT-24700430
[Presentation] TEX101, testis specific GPI-anchored protein, is required for sperm fertility in mouse
- Author(s)
  藤原祥高
- Organizer
  第2回新学術領域アロ認証国際シンポジウム
- Place of Presentation
  ホテル名古屋ガーデンパレス
- Data Source
  KAKENHI-PROJECT-24700430

1. IKAWA MASAHITO (20304066)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
2. ISOTANI Ayako (20444523)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. MIYATA Haruhiko (50604732)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. SATOUH Yuhkoh (40545571)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. 高島誠司 (40396891)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. Kiyozumi Daiji (70452430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MORI Masashi (00747941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 江森千紘 (10868136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 櫻井伸行 (10808281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 吉田恵一 (90365437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 岩森督子 (10711509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. YAMAZAKI Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. UENO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 岡部勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
15. 野田大地

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 吉田松生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 米田悦啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 岡正啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. Lu Yonggang

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
20. フヤオペン

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 石野史敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 石野知子(金児知子)

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 徳弘圭造

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 小野竜一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 嶋田圭祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 井上直和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 山下俊英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujihara Yoshitaka 藤原 祥高

FUJIHARA Yoshitaka 藤原 祥高

Research Projects

Research Products

Co-Researchers

Comprehensive Analysis of Evolutionarily Conserved Genes Vital for Mammalian Reproduction using Genetically Modified AnimalsPrincipal Investigator

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遺伝的要因・環境要因の組み合わせ最適化による特発性造精機能障害モデルマウスの開発

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Novel roles of seminolipid in the mouse testis

Principal Investigator

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Elucidating the universality and specificity of reproductive mechanisms between species using genetically modified animalsPrincipal Investigator

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Development of new diagnostic markers and reversible fertility inhibitors for mammalian spermatozoaPrincipal Investigator

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Elucidating the molecular mechanisms of fertilization common to vertebrate animal modelsPrincipal Investigator

Principal Investigator

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Developing male contraceptives targeting sperm membrane proteins using the DEC-Tec library(Fostering Joint International Research)Principal Investigator

Principal Investigator

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Analysis of mammalian germ cell-specific GPI-anchored proteins using genetically modified animalsPrincipal Investigator

Principal Investigator

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Development of method for CRISPR/Cas9 mediated genome editing in micePrincipal Investigator

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Analysis of extracellular matrices that regulate mammalian reproduction

Principal Investigator

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Application of CRISPR/Cas9 system for gene manipulation in mice

Principal Investigator

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Functional analysis of fertilization related genes in mice

Principal Investigator

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Review Section

Research Institution

Analysis of male germ cell specific GPI-anchored proteins using gene-manipulated micePrincipal Investigator

Principal Investigator

Project Period (FY)

Fujihara Yoshitaka 藤原祥高

FUJIHARA Yoshitaka 藤原祥高

[Book] 「マウスにおけるCRISPR/Cas9を用いた遺伝子改変」、実験医学別冊　最強のステップUPシリーズ　今すぐ始めるゲノム編集2014