HIGASHI Takaaki 東孝暁

Researcher Number	70594878
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2022: 熊本大学, 大学院生命科学研究部(医), 特定研究員 2020: 熊本大学, 病院, 非常勤診療医師 2019: 熊本大学, 病院, 医員 2016 – 2018: 熊本大学, 医学部附属病院, 非常勤診療医師
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Digestive surgery
Keywords	Principal Investigator スタチン / CXCL12-CXCR4 axis / CXCL12-CXCR4 signaling / signaling / CXCL12-CXCR4 / CAF / Hippo pathway / 膵癌 / 癌微小環境 / 薬剤感受性 … More / Gene Signature / メタボリックシンドローム / 186 gene signature / 発癌予測 / 肝細胞癌 / 非アルコール性脂肪性肝疾患（NAFLD） / 非アルコール性脂肪肝炎（NASH） … More Except Principal Investigator TSP-1 / 免疫学的癌微小環境 / サルコペニア / TNF-α / 腫瘍浸潤マクロファージ / 腫瘍免疫 / PD-L1 / PD-1 / 腫瘍微小環境 / マクロファージ / 膵癌 / 免疫チェックポイント / 腫瘍免疫学 / LSKL peptide / Sorafenib / TGF-β / Hepatectomy / HCC / 肝再生 / 肝切除術 / SB203580 / p38 MAP kinase / sorafenib / Thrombospondin 1 / 肝細胞癌 / 肝中心静脈閉塞症 / bevacizumab / Thrombospondin-1（TSP-1） / oxaliplatin / 肝類洞閉塞症候群 / 大腸癌肝転移 / Glut1 / 癌糖代謝 / 膵臓外科学 / Hippo-pathway / 抗がん剤抵抗性 / Taz / Yap / TAZ / YAP / 癌幹細胞 / Hippo pathway / 消化器癌 / statin（スタチン） / Elk-1 / pAkt / pERK / 薬剤耐性 / 相乗効果 / 併用療法 / BRAF / K-ras / Akt/PKB / MEK/ERK / 大腸癌 / スタチン Less

Interaction between Hippo pathway and cancer microenvironment in pancreatic cancer.Principal Investigator
- Principal Investigator
  
  Higashi Takaaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kumamoto University
TSP-1 expression of hepatocellular carcinoma in recurrence and metastasis after hepatectomy: the mechanism and therapeutic strategy.
- Principal Investigator
  
  Kuroki Hideyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Sarcopenia and immunological tumor microenvironment
- Principal Investigator
  
  Imai Katsunori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Elucidation of anti-tumor effect mechanism of statin in colorectal cancer and development of new treatment
- Principal Investigator
  
  ISHIKAWA Shinji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Biological significance of Hippo-pathway in gastrointestinal cancer
- Principal Investigator
  
  HAYASHI Hiromitsu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Therapeutic development for pancreatic cancer via cancer specific glucose metabolism
- Principal Investigator
  
  HASHIMOTO Daisuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Prediction for HCC development and the effect of statin for NASH patientsPrincipal Investigator
- Principal Investigator
  
  HIGASHI Takaaki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Clarification the molecular mechanism of chemotherapy-related sinusoidal obstructive syndrome and the study for efficacy of anti–vascular endothelial growth factor therapy.
- Principal Investigator
  
  KUROKI Hideyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University

All 2023 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer.2023
- Author(s)
  Liu Z,
- Journal Title
  
  Br J Cancer.
  
  Volume: 128(5) Issue: 5 Pages: 844-856
- DOI
  10.1038/s41416-022-02106-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08757, KAKENHI-PROJECT-20K09059, KAKENHI-PROJECT-20K09081, KAKENHI-PROJECT-21K15534
[Journal Article] In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment.2018
- Author(s)
  Hirschfield H, Bian CB, Higashi T, Nakagawa S, Zeleke TZ, Nair VD, Fuchs BC, Hoshida Y.
- Journal Title
  
  Exp Mol Med.
  
  Volume: 50(1) Issue: 1 Pages: e419-e419
- DOI
  10.1038/emm.2017.164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19940
[Journal Article] Enhancer of zeste homolog 2 (EZH2) regulates tumor angiogenesis and predicts recurrence and prognosis of intrahepatic cholangiocarcinoma2018
- Author(s)
  Nakagawa Shigeki、Okabe Hirohisa、Ouchi Mayuko、Tokunaga Ryuma、Umezaki Naoki、Higashi Takaaki、Kaida Takatoshi、Arima Kota、Kitano Yuki、Kuroki Hideyuki、Mima Kosuke、Nitta Hidetoshi、Imai Katsunori、Hashimoto Daisuke、Yamashita Yo-ichi、Chikamoto Akira、Baba Hideo
- Journal Title
  
  HPB
  
  Volume: 20 Issue: 10 Pages: 939-948
- DOI
  10.1016/j.hpb.2018.03.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10670, KAKENHI-PROJECT-18K16369, KAKENHI-PROJECT-18K16370, KAKENHI-PROJECT-16K19939
[Journal Article] Impact of surgical treatment after sorafenib therapy for advanced hepatocellular carcinoma2018
- Author(s)
  Takeyama Hideaki、Beppu Toru、Higashi Takaaki、Kaida Takayoshi、Arima Kota、Taki Katsunobu、Imai Katsunori、Nitta Hidetoshi、Hayashi Hiromitsu、Nakagawa Shigeki、Okabe Hirohisa、Hashimoto Daisuke、Chikamoto Akira、Ishiko Takatoshi、Tanaka Motohiko、Sasaki Yutaka、Baba Hideo
- Journal Title
  
  Surgery Today
  
  Volume: 48 Issue: 4 Pages: 431-438
- DOI
  10.1007/s00595-017-1603-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10670
[Journal Article] Cell type-specific pharmacological kinase inhibition for cancer chemoprevention.2018
- Author(s)
  Deshmukh M, Nakagawa S, Higashi T, Vincek A, Venkatesh A, Ruiz de Galarreta M, Koh AP, Goossens N, Hirschfield H, Bian CB, Fujiwara N, Ono A, Hoshida H, El-Abtah M, Ahmad NB, Lujambio A, Sanchez R, Fuchs BC, Poelstra K, Prakash J, Hoshida Y.
- Journal Title
  
  Nanomedicine.
  
  Volume: 14(2) Issue: 2 Pages: 317-325
- DOI
  10.1016/j.nano.2017.11.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19940, KAKENHI-PROJECT-16K19939
[Journal Article] Erratum to: Sarcopenia, but not visceral fat amount, is a risk factor of postoperative complications after major hepatectomy.2017
- Author(s)
  Higashi T, Hayashi H, Taki K, Sakamoto K, Kuroki H, Nitta H, Hashimoto D, Chikamoto A, Beppu T, Baba H.
- Journal Title
  
  Int J Clin Oncol.
  
  Volume: 22(5) Issue: 5 Pages: 986-990
- DOI
  10.1007/s10147-017-1163-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10670
[Journal Article] Hepatic stellate cells as key target in liver fibrosis.2017
- Author(s)
  Higashi T, Friedman SL, Hoshida Y
- Journal Title
  
  Adv Drug Deliv Rev.
  
  Volume: 121 Pages: 27-42
- DOI
  10.1016/j.addr.2017.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19940
[Journal Article] Thrombospondin-1 expression may be implicated in liver atrophic mechanism due to obstructed portal venous flow.2016
- Author(s)
  Hayashi H, Kuroki H, Higashi T, Takeyama H, Yokoyama N, Okabe H, Nitta H, Beppu T, Takamori H, Baba H.
- Journal Title
  
  Hepatol Res
  
  Volume: Epub Issue: 8 Pages: 803-812
- DOI
  10.1111/hepr.12792
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462046, KAKENHI-PROJECT-17K10670
[Journal Article] Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma.2016
- Author(s)
  Higashi T, Hayashi H, Kitano Y, Yamamura K, Kaida T, Arima K, Taki K, Nakagawa S, Okabe H, Nitta H, Imai K, Hashimoto D, Chikamoto A, Beppu T, Baba H.
- Journal Title
  
  Med Oncol.
  
  Volume: 33(11) Issue: 11 Pages: 123-123
- DOI
  10.1007/s12032-016-0845-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10191, KAKENHI-PROJECT-16K19939, KAKENHI-PROJECT-16K19940
[Journal Article] Heterogeneity of KRAS Mutations in Pancreatic Ductal Adenocarcinoma2016
- Author(s)
  Hashimoto D, Arima K, Yokoyama N, Chikamoto A, Taki K, Inoue R, Kaida T, Higashi T, Nitta H, Ohmuraya M, Hirota M, Beppu T, Baba H
- Journal Title
  
  Pancreas
  
  Volume: 45 Issue: 8 Pages: 1111-1114
- DOI
  10.1097/mpa.0000000000000624
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-15K10191, KAKENHI-PROJECT-16K10604
[Journal Article] Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition.2016
- Author(s)
  Nakagawa S, Higashi T, Goossens N, Bain G, Lauwers GY, Koh AP, El-Abtah M, Ahmad NB, Hoshida H, Erstad DJ, Gunasekaran G, Lee Y, Yu ML, Chuang WL, Dai CY, Baba H, Mahajan M, Nair VD, Lanuti M, Iavarone M, Colombo M, Llovet JM, Tager AM, Schwarz ME, Chung RT, Tanabe KK, Zhang B, Fuchs BC, Hoshida Y, et al.
- Journal Title
  
  Cancer Cell
  
  Volume: 30(6) Issue: 6 Pages: 879-890
- DOI
  10.1016/j.ccell.2016.11.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19939, KAKENHI-PROJECT-16K19940
[Presentation] 肝細胞癌の分子分類と個別化治療への応用2019
- Author(s)
  東　孝暁、松村　和季、清水　健次、小川　克大、新田　英利、増田　稔郎、赤星　慎一、松本　克孝、生田　義明、沖野　哲也、中川　茂樹、星田　有人、馬場　秀夫、高森　啓史
- Organizer
  第119回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10670
[Presentation] 腫瘍浸潤マクロファージ由来の TNF-αが膵癌におけるPD-L1の発現を増強し、予後不良の原因になる2019
- Author(s)
  塚本雅代、今井克憲、石本崇胤、菰原義弘、山下洋市、中川茂樹、梅崎直紀、山尾宣暢、伊東山瑠美、中尾陽佑、遊佐俊彦、宮田辰徳、岡部弘尚、近本亮、石河隆敏、廣田昌彦、馬場秀夫
- Organizer
  第40回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-17K10704
[Presentation] 腫瘍浸潤マクロファージが膵癌におけるPD-L1の発現を増強する2019
- Author(s)
  塚本雅代、今井克憲、石本崇胤、梅崎直紀、山尾宣暢、伊東山瑠美、中尾陽佑、遊佐俊彦、有馬浩太、宮田辰徳、岡部弘尚、中川茂樹、橋本大輔、山下洋市、近本亮、石河隆敏、馬場秀夫
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10704
[Presentation] 膵癌，胆道癌の腹膜播種に対する審査腹腔鏡の意義と治療戦略2018
- Author(s)
  橋本大輔、伊東山瑠美、中尾陽佑、梅﨑直紀、北野雄希、有馬浩太、中川茂樹、近本　亮、松村富二夫、馬場秀夫
- Organizer
  第73回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10604
[Presentation] 腫瘍浸潤マクロファージが膵癌におけるPD-L1の発現を増強する2017
- Author(s)
  塚本雅代、今井克憲、石本崇胤、梅崎直紀、山尾宣暢、伊東山瑠美、中尾陽佑、遊佐俊彦、北野雄希、有馬浩太、宮田辰徳、山村謙介、岡部弘尚、中川茂樹、橋本大輔、山下洋市、近本　亮、石河隆敏、馬場秀夫
- Organizer
  第28回日本消化器癌発生学会総会・第28回国際消化器癌発生会議
- Data Source
  KAKENHI-PROJECT-17K10704
[Presentation] 肝再生および肝萎縮におけるトロンボスポンディン1の役割解明と臨床応用への探索2017
- Author(s)
  林洋光、黒木秀幸、東孝暁:、武山秀晶、岡部弘尚、今井克憲、山下洋市、高森啓史、馬場秀夫
- Organizer
  第117回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10670
[Presentation] 肝再生および肝萎縮におけるトロンボスポンディン1の役割解明と臨床応用への探索2017
- Author(s)
  林　洋光、黒木秀幸、東孝暁、武山秀晶、岡部弘尚、今井克憲、山下洋市、高森啓史、馬場秀夫
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10578
[Presentation] Hippo-pathwayを介した癌幹細胞性獲得機構の解明と治療への応用2016
- Author(s)
  林洋光、東孝暁、横山奈穂美、甲斐田剛圭、新田英利、橋本大輔、近本　亮、別府　透、高森啓史、馬場秀夫
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場（大阪府）
- Data Source
  KAKENHI-PROJECT-16K10578
[Presentation] 肝切除後の血漿中Thrombospondin-1変化の肝障害の予測因子としての可能性2016
- Author(s)
  黒木秀幸、林洋光、中川茂樹、東孝暁、橋本大輔、新田英利、近本　亮、石河隆敏、別府　透、馬場秀夫
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場（大阪府）
- Data Source
  KAKENHI-PROJECT-15K19898
[Presentation] 膵頭十二指腸切除術後の手術関連死亡ゼロを目指して2016
- Author(s)
  橋本大輔、近本　亮、有馬浩太、甲斐田剛圭、髙城克暢、東孝暁、今井克憲、山下洋市、別府　透、馬場秀夫
- Organizer
  第28回日本肝胆膵外科学会・学術集会
- Place of Presentation
  大阪国際会議場（大阪府）
- Data Source
  KAKENHI-PROJECT-16K10604

1. HAYASHI Hiromitsu (80625773)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
2. NAKAGAWA Shigeki (10594872)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
3. Imai Katsunori (60555746)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
4. KUROKI Hideyuki (50594876)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. 山村謙介 (10816507)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ISHIKAWA Shinji (80419639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HASHIMOTO Daisuke (80508507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 徳永竜馬 (20594881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 宮本裕士 (80551259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 美馬浩介 (00546559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 澤山浩 (40594875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 高森啓史 (90363514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 宮田辰徳 (80594887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. CHIKAMOTO Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. OHMURAYA Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 馬場秀夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 岡部弘尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGASHI Takaaki 東 孝暁

Research Projects

Research Products

Co-Researchers

Interaction between Hippo pathway and cancer microenvironment in pancreatic cancer.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

TSP-1 expression of hepatocellular carcinoma in recurrence and metastasis after hepatectomy: the mechanism and therapeutic strategy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sarcopenia and immunological tumor microenvironment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of anti-tumor effect mechanism of statin in colorectal cancer and development of new treatment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biological significance of Hippo-pathway in gastrointestinal cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic development for pancreatic cancer via cancer specific glucose metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction for HCC development and the effect of statin for NASH patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification the molecular mechanism of chemotherapy-related sinusoidal obstructive syndrome and the study for efficacy of anti&#8211;vascular endothelial growth factor therapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhancer of zeste homolog 2 (EZH2) regulates tumor angiogenesis and predicts recurrence and prognosis of intrahepatic cholangiocarcinoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of surgical treatment after sorafenib therapy for advanced hepatocellular carcinoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell type-specific pharmacological kinase inhibition for cancer chemoprevention.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Erratum to: Sarcopenia, but not visceral fat amount, is a risk factor of postoperative complications after major hepatectomy.2017

Author(s)

Journal Title

HIGASHI Takaaki 東孝暁

Clarification the molecular mechanism of chemotherapy-related sinusoidal obstructive syndrome and the study for efficacy of anti–vascular endothelial growth factor therapy.