SEKINE Shiori 関根史織

… Alternative Names

関根史織セキネシオリ

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Researcher Number	70612654
Affiliation (based on the past Project Information) *help	2019: 東京大学, 薬学研究科(研究院), 助教 2017: 東京大学, 大学院薬学系研究科, 助教 2014 – 2015: 東京大学, 大学院薬学系研究科(薬学部), 助教
Review Section/Research Field	Except Principal Investigator Biological Sciences / Biological pharmacy
Keywords	Except Principal Investigator ストレス / シグナル伝達 / ミトコンドリアストレス / 小胞体ストレス / 浸透圧ストレス / 酸化ストレス / ASKファミリー / ASK1

Signal transduction by redox sensor molecules
- Principal Investigator
  
  Miki Hiroaki
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Homeostasis Regulation via Stress Signaling and its Molecular Basis for Drug Development
- Principal Investigator
  
  ICHIJO Hidenori
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

All 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Structures of PGAM5 provide insight into active site plasticity and multimeric assembly.2017
- Author(s)
  Chaikuad, A., Filippakopoulos, P., Marcsisin, S. R., Picaud, S., Schroder, M., Sekine, S., Ichij, H., Engen, J. R., Takeda, K., Knapp, S.
- Journal Title
  
  Structure 25, 1089-1099 (2017)
  
  Volume: 25 Issue: 7 Pages: 1089-1099
- DOI
  10.1016/j.str.2017.05.020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19768, KAKENHI-PUBLICLY-17H05511, KAKENHI-PROJECT-25221302, KAKENHI-PROJECT-16K15115, KAKENHI-PLANNED-26114009
[Journal Article] The ablation of mitochondrial protein phosphatase pgam5 confers resistance against metabolic stress2016
- Author(s)
  Sekine S., Yao, A., Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K., Ichijo, H
- Journal Title
  
  EBioMedicine
  
  Volume: 6 Pages: 82-92
- DOI
  10.1016/j.ebiom.2016.01.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01388, KAKENHI-PLANNED-26111007, KAKENHI-PUBLICLY-26111519, KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-26293016, KAKENHI-PLANNED-26114009, KAKENHI-PROJECT-25221302
[Journal Article] KLHDC10 deficiency protects mice against TNFα-induced systemic inflammation.2016
- Author(s)
  Yamaguchi, N., Sekine, S., Naguro, I., Sekine, Y. and Ichijo, H.
- Journal Title
  
  PLOS one
  
  Volume: 11 Issue: 9 Pages: e0163118-e0163118
- DOI
  10.1371/journal.pone.0163118
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221302, KAKENHI-PROJECT-16K15115, KAKENHI-PLANNED-26114009
[Journal Article] Apoptosis Signal-regulating Kinase 1(ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for oxidative stress-induced necrosis2015
- Author(s)
  Watanabe T, Sekine S, Naguro I, Sekine Y, Ichijo H.
- Journal Title
  
  J Biol Chem
  
  Volume: in press Issue: 17 Pages: 10791-10803
- DOI
  10.1074/jbc.m114.623280
- NAID
  120007150218
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25650004, KAKENHI-PLANNED-26114009, KAKENHI-PLANNED-26111007, KAKENHI-PROJECT-25221302
[Journal Article] Mitochondrial proteolysis: Its emerging roles in stress responses.2015
- Author(s)
  Sekine, S. and Ichijo, H.
- Journal Title
  
  B.B.A.
  
  Volume: 1850 Issue: 2 Pages: 274-280
- DOI
  10.1016/j.bbagen.2014.10.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25650061, KAKENHI-PLANNED-26111007, KAKENHI-PROJECT-25221302
[Journal Article] The DEAH-Box RNA Helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses2014
- Author(s)
  Mosallanejad, K., Sekine, Y., Ishikura-Kinoshita, S., Kumagai, K., Nagano, T., Matsuzawa, A., Takeda, K., Naguro, I. and Ichijo, H.
- Journal Title
  
  Sci. Signal.
  
  Volume: 7 Issue: 323
- DOI
  10.1126/scisignal.2004841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229004, KAKENHI-PROJECT-25221302, KAKENHI-PROJECT-25650004, KAKENHI-PROJECT-25650061, KAKENHI-PROJECT-26293011, KAKENHI-PROJECT-26293016, KAKENHI-PLANNED-26114009
[Presentation] ミトコンドリアにおけるストレス応答シグナル解析2016
- Author(s)
  関根　史織、一條　秀憲
- Organizer
  第８９回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PLANNED-26111007
[Presentation] ミトコンドリア局在ホスファターゼPGAM5欠損マウスの表現型解析2015
- Author(s)
  関根史織
- Organizer
  Young Mito2015
- Place of Presentation
  千葉
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PLANNED-26111007
[Presentation] ミトコンドリア内膜局在型プロテインホスファターゼPGAM5の個体レベルでの生理機能解析2015
- Author(s)
  関根　史織、一條　秀憲
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PLANNED-26111007
[Presentation] ケルヒリピートタンパク質 KLHDC10 の全身炎症反応症候群 (SIRS) における新規機能の解析2014
- Author(s)
  山口奈美子、関根悠介、関根史織、一條秀憲
- Organizer
  第 23 回日本 Cell Death 学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PLANNED-26111007

1. FUJISAWA Takao (50636644)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. ICHIJO Hidenori (00242206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. NAGURO Isao (80401222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. Miki Hiroaki (80302602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 服部一輝 (40708575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 武田弘資

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SEKINE Shiori 関根 史織

関根 史織 セキネ シオリ

Research Projects

Research Products

Co-Researchers

Signal transduction by redox sensor molecules

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Homeostasis Regulation via Stress Signaling and its Molecular Basis for Drug Development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structures of PGAM5 provide insight into active site plasticity and multimeric assembly.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The ablation of mitochondrial protein phosphatase pgam5 confers resistance against metabolic stress2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KLHDC10 deficiency protects mice against TNFα-induced systemic inflammation.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apoptosis Signal-regulating Kinase 1(ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for oxidative stress-induced necrosis2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Mitochondrial proteolysis: Its emerging roles in stress responses.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The DEAH-Box RNA Helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] ミトコンドリアにおけるストレス応答シグナル解析2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ミトコンドリア局在ホスファターゼPGAM5欠損マウスの表現型解析2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ミトコンドリア内膜局在型プロテインホスファターゼPGAM5の個体レベルでの生理機能解析2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ケルヒリピートタンパク質 KLHDC10 の全身炎症反応症候群 (SIRS) における新規機能の解析2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

SEKINE Shiori 関根史織

関根史織セキネシオリ