LI HENG 李コウ

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LI Heng 李コウ

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Researcher Number	70621994
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所病態生化学研究部, 科研費研究員
Affiliation (based on the past Project Information) *help	2023: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所病態生化学研究部, 科研費研究員 2016 – 2022: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第二部, 科研費研究員 2015: 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所知的障害研究部, 科研費研究員 2015: 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所・知的障害研究部, 流動研究員 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第2部, 科研費研究員 … More 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第二部, 科研費研究員 2013 – 2014: 独立行政法人国立精神・神経医療研究センター, 精神保健研究所知的障害研究部, 科研費研究員 2013: 独立行政法人国立精神・神経医療研究センター, 精神保健研究所知的障害研究部, 流動研究員 2012: 独立行政法人国立精神・神経医療研究センター, その他部局等, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Biomedical engineering/Biological material science Except Principal Investigator Psychiatric science
Keywords	Principal Investigator 大脳白質形成不全症 / Pelizaeus-Merzbacher病 / 小胞体 / カルシウム恒常性 / 髄鞘形成不全 / ペリツェウス・メルツバッハー病 / 神経変性 / 先天性大脳白質形成不全 / ミトコンドリア / ミトコンドリア機能障害 … More / 小胞体カルシウム枯渇 / 細胞病態 / カルシウム / 膜輸送 / ER-Golgi輸送 / カルシウム枯渇 / 細胞内輸送 / 神経障害 / 病態解析 / 胎児低酸素症 / 胎児低酸素血症 / 胎児脳 / 人工赤血球 … More Except Principal Investigator GABA神経系 / 不安 Less

カルシウム恒常性障害に着目した先天性大脳白質形成不全症の新規細胞病態の解明Principal Investigator
- Principal Investigator
  
  李コウ
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center of Neurology and Psychiatry
The study of novel cell pathology of congenital dysplasia of cortical white matter focusing on globally impaired membrane traffickingPrincipal Investigator
- Principal Investigator
  
  Li Heng
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center of Neurology and Psychiatry
The study of neurodegeneration as a prognostic factor in congenital dysplasia of cortical white matterPrincipal Investigator
- Principal Investigator
  
  Li Heng
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  National Center of Neurology and Psychiatry
Identification of anxiety induced gene and therapeutic approach
- Principal Investigator
  
  Inagaki Masumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  National Center of Neurology and Psychiatry
Development of a novel therapy for fetal hypoxia used by artificial oxygen carriers (hemoglobin vesicles)Principal Investigator
- Principal Investigator
  
  LI Heng
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Center of Neurology and Psychiatry

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2013

All Journal Article Presentation

[Journal Article] Abnormality in GABAergic postsynaptic transmission associated with anxiety in Bronx waltzer mice with an Srrm4 mutation2024
- Author(s)
  Shirakawa Yuka, Li Heng, Inoue Yuki, Izumi Hitomi, Kaga Yoshimi, Goto Yu-ichi, Inoue Ken, Inagaki Masumi
- Journal Title
  
  IBRO Neuroscience Reports
  
  Volume: 16 Pages: 67-77
- DOI
  10.1016/j.ibneur.2023.12.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K13967, KAKENHI-PROJECT-22K07900, KAKENHI-PROJECT-21H02886
[Journal Article] POLR1C variants dysregulate splicing and cause hypomyelinating leukodystrophy2020
- Author(s)
  Kashiki Hitoshi、Li Heng、Miyamoto Sachiko、Ueno Hiroe、Tsurusaki Yoshinori、Ikeda Chizuru、Kurata Hirofumi、Okada Takumi、Shimazu Tomoyuki、Imamura Hoseki、Enomoto Yumi、Takanashi Jun-ichi、Kurosawa Kenji、Saitsu Hirotomo、Inoue Ken
- Journal Title
  
  Neurology Genetics
  
  Volume: 6 Issue: 6 Pages: 1-7
- DOI
  10.1212/nxg.0000000000000524
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08237, KAKENHI-PROJECT-19K08358, KAKENHI-PROJECT-20H03641, KAKENHI-PROJECT-19K22606
[Journal Article] Gene suppressing therapy for Pelizaeus-Merzbacher disease using artificial microRNA2019
- Author(s)
  Li Heng、Okada Hironori、Suzuki Sadafumi、Sakai Kazuhisa、Izumi Hitomi、Matsushima Yukiko、Ichinohe Noritaka、Goto Yu-ichi、Okada Takashi、Inoue Ken
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 10 Pages: 125052-125052
- DOI
  10.1172/jci.insight.125052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05361, KAKENHI-PROJECT-16K19679, KAKENHI-PROJECT-19K08358, KAKENHI-PROJECT-17H00892, KAKENHI-PROJECT-19K22606
[Presentation] Mitochondrial dysfunction via calcium homeostasis disruption as a cellular pathogenesis of Pelizaeus-Merzbacher Disease2023
- Author(s)
  Heng Li, Reiko Mishima, Ken Inoue
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07900
[Presentation] Globally impaired ER-Golgi trafficking via ER calcium depletion as a cellular pathogenesis of Pelizaeus-Merzbacher Disease2022
- Author(s)
  Heng Li, Reiko Mishima, Yu-ichi Goto, Ken Inoue
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07900
[Presentation] Impairment ER-Golgi trafficking via ER calcium depletion as a cellular pathogenesis of Pelizaeus-Merzbacher Disease2021
- Author(s)
  Heng Li, Yu-ichi Goto, Ken inoue
- Organizer
  第４４回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K08358
[Presentation] Globally impaired ER-Golgi trafficking as a cellular pathogenesis of Pelizaeus-Merzbacher disease2020
- Author(s)
  Heng Li, Yu-ichi Goto, Ken Inoue
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K08358
[Presentation] Gene suppressing therapy for Pelizaeus Merzbacher disease using artificial miRNA2019
- Author(s)
  Heng Li, Hironori Okada, Sadafumi Suzuki, Kazuhisa Sakai, Hitomi Izumi, Yukiko Matsushima, Noritaka Ichinohe, Yu-ichi Goto, Takashi Okada, and Ken Inoue
- Organizer
  日本神経科学学会　第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08358
[Presentation] Development of AAV enabling oligodendrocyte-specific gene suppression: implication for the treatment of Pelizaeus-Merzbacher disease2018
- Author(s)
  Heng Li, Hironori Okada, Sadafumi Suzuki, Kazuhisa Sakai, Takashi Okada, Noritaka Ichinohe, Yu-ichi Goto, Ken Inoue
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K19679
[Presentation] Globally Impaired ER-Golgi trafficking as a cellular pathogenesis of Pelizaeus-Merzbacher Disease2017
- Author(s)
  李コウ
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16K19679
[Presentation] ER-Golgi transport may serve as a novel drug target for Pelizaeus-Merzbacher disease caused by PLP1 amino acid substitutions2016
- Author(s)
  Ken Inoue, Heng Li, P.R. Mangalika, Yu-ichi Goto
- Organizer
  第13回国際人類遺伝学会
- Place of Presentation
  国立京都国際会館, 京都, 日本
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19679
[Presentation] Impaired ER-Golgi trafficking as a novel therapeutic target for Pelizaeus-Merzbacher disease caused by PLP1 amino acid substitutions.2016
- Author(s)
  Ken Inoue, Heng Li, P.R. Mangalika, Yu-ichiGoto
- Organizer
  The American Society of Human Genetics Annual Meeting 2016
- Place of Presentation
  The Vancouver Convention Center, Vancouver, Canada
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19679
[Presentation] 不安様行動におけるCCKA 、CCKB 受容体の異なる役割2013
- Author(s)
  李コウ，太田英伸，泉仁美，松田芳樹，関美佳，戸田宜子，秋山美沙紀，松島由紀子，加我牧子，稲垣真澄
- Organizer
  神経科学会
- Place of Presentation
  京都　国際会議場
- Data Source
  KAKENHI-PROJECT-25461745

1. INAGAKI Masumi (70203198)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. OHTA Hidenobu (80422103)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. INOUE Ken (30392418)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. SAKAI Hiromi (70318830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KAGA Makiko (20142250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. OSAKABE Hitomi (30625520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUGIURA Yuka (50750402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 高梨潤一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

LI HENG 李 コウ

LI Heng 李 コウ

Research Projects

Research Products

Co-Researchers

カルシウム恒常性障害に着目した先天性大脳白質形成不全症の新規細胞病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study of novel cell pathology of congenital dysplasia of cortical white matter focusing on globally impaired membrane traffickingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study of neurodegeneration as a prognostic factor in congenital dysplasia of cortical white matterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of anxiety induced gene and therapeutic approach

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel therapy for fetal hypoxia used by artificial oxygen carriers (hemoglobin vesicles)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Abnormality in GABAergic postsynaptic transmission associated with anxiety in Bronx waltzer mice with an Srrm4 mutation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] POLR1C variants dysregulate splicing and cause hypomyelinating leukodystrophy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene suppressing therapy for Pelizaeus-Merzbacher disease using artificial microRNA2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Mitochondrial dysfunction via calcium homeostasis disruption as a cellular pathogenesis of Pelizaeus-Merzbacher Disease2023

Author(s)

Organizer

Data Source

[Presentation] Globally impaired ER-Golgi trafficking via ER calcium depletion as a cellular pathogenesis of Pelizaeus-Merzbacher Disease2022

Author(s)

Organizer

Data Source

[Presentation] Impairment ER-Golgi trafficking via ER calcium depletion as a cellular pathogenesis of Pelizaeus-Merzbacher Disease2021

Author(s)

Organizer

Data Source

[Presentation] Globally impaired ER-Golgi trafficking as a cellular pathogenesis of Pelizaeus-Merzbacher disease2020

Author(s)

Organizer

Data Source

[Presentation] Gene suppressing therapy for Pelizaeus Merzbacher disease using artificial miRNA2019

Author(s)

Organizer

Data Source

[Presentation] Development of AAV enabling oligodendrocyte-specific gene suppression: implication for the treatment of Pelizaeus-Merzbacher disease2018

Author(s)

Organizer

Data Source

[Presentation] Globally Impaired ER-Golgi trafficking as a cellular pathogenesis of Pelizaeus-Merzbacher Disease2017

Author(s)

Organizer

Data Source

[Presentation] ER-Golgi transport may serve as a novel drug target for Pelizaeus-Merzbacher disease caused by PLP1 amino acid substitutions2016

Author(s)

LI HENG 李コウ

LI Heng 李コウ