Tamura Kaoru 田村郁

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TAMURA Kaoru 田村郁

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Researcher Number	70629146
Other IDs
Affiliation (Current)	2025: 東京科学大学, 東京科学大学病院, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京医科歯科大学, 東京医科歯科大学病院, 講師 2022 – 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2021: 東京医科歯科大学, 東京医科歯科大学病院, 助教 2020: 東京医科歯科大学, 医学部附属病院, 助教 2013 – 2018: 東京医科歯科大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related / Neurosurgery Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 90120:Biomaterials-related
Keywords	Principal Investigator がん幹細胞 / microRNA / 悪性脳腫瘍 / cancer stem cell / 治療抵抗性 / 脳腫瘍 / 脂質代謝 / ホスホイノシタイド / グリオーマ / 脳神経疾患 … More / 膠芽腫 / バイオマーカー / Glioma / glioma / glioma stem cell / brain tumor / 幹細胞 … More Except Principal Investigator がん細胞 / リン脂質 / 脂質代謝 / 質量分析 / がん / 脳腫瘍 / X線治療 / DDS Less

Size-tunable drug delivery systems for their application to X-ray therapy for brain tumors
- Principal Investigator
  
  内藤瑞
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  The University of Tokyo
新規計測技術による腫瘍制御性リン脂質代謝系の解明
- Principal Investigator
  
  佐々木雄彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tokyo Medical and Dental University
脂質代謝をターゲットとした悪性脳腫瘍の治療抵抗性機序の解明とその克服Principal Investigator
- Principal Investigator
  
  田村郁
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Tokyo Medical and Dental University
Development of novel therapy and biomarkers for malignant brain tumors based on microRNA analysisPrincipal Investigator
- Principal Investigator
  
  Tamura Kaoru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Tokyo Medical and Dental University
New treatment strategy for resistant brain tumors targeting brain tumor stem cellPrincipal Investigator
- Principal Investigator
  
  TAMURA Kaoru
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Tokyo Medical and Dental University
Combination therapy with micro RNA and therapeutic stem cells expressing TRAIL overcomes resistant brain tumorPrincipal Investigator
- Principal Investigator
  
  TAMURA Kaoru
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2020 2018 2017 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Correlation of Intraoperative 5-ALA-Induced Fluorescence Intensity and Preoperative 11C-Methionine PET Uptake in Glioma Surgery2022
- Author(s)
  Shimizu K, Tamura K, Hara S, Inaji M, Tanaka Y, Kobayashi D, Sugawara T, Wakimoto H, Nariai T, Ishii K, Sakuma I, Maehara T
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 6 Pages: 1449-1449
- DOI
  10.3390/cancers14061449
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09321, KAKENHI-PROJECT-20K09341
[Journal Article] Ischemic Stroke with Multiple Cerebral Artery Stenosis in a Patient with an Anaplastic Astrocytoma during Bevacizumab Treatment: A Case Report2022
- Author(s)
  NODA Mariko、INAJI Motoki、KARAKAMA Jun、ARAI Yukika、KUROHA Masae、TAMURA Kaoru、TANAKA Yoji、MAEHARA Taketoshi
- Journal Title
  
  NMC Case Report Journal
  
  Volume: 9 Issue: 0 Pages: 13-17
- DOI
  10.2176/jns-nmc.2021-0297
- NAID
  130008163373
- ISSN
  2188-4226
- Year and Date
  2022-12-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09341, KAKENHI-PROJECT-20K09321
[Journal Article] microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis2018
- Author(s)
  Bhere Deepak、Tamura Kaoru、Wakimoto Hiroaki、Choi Sung Hugh、Purow Benjamin、Debatisse Jeremy、Shah Khalid
- Journal Title
  
  Neuro-Oncology
  
  Volume: 20 Issue: 2 Pages: 215-224
- DOI
  10.1093/neuonc/nox138
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19954
[Journal Article] 症例放射線照射3年6カ月後に発症したradiation-induced meningiomaの1例2018
- Author(s)
  荒井雪花、成相直、前原健寿、壽美田一貴、田村郁、小林大輔、唐鎌淳、伊藤慧、黒羽真砂恵、稲次基希、田中洋次
- Journal Title
  
  Neurological Surgery 脳神経外科
  
  Volume: 46 Issue: 6 Pages: 515-521
- DOI
  10.11477/mf.1436203761
- ISSN
  0301-2603, 1882-1251
- Year and Date
  2018-06-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19954
[Journal Article] Usefulness of <sup>11</sup>C-Methionine Positron Emission Tomography for Monitoring of Treatment Response and Recurrence in a Glioblastoma Patient on Bevacizumab Therapy: A Case Report2018
- Author(s)
  Nakano Tomoyuki、Tamura Kaoru、Tanaka Yoji、Inaji Motoki、Hayashi Shihori、Kobayashi Daisuke、Nariai Tadashi、Toyohara Jun、Ishii Kenji、Maehara Taketoshi
- Journal Title
  
  Case Reports in Oncology
  
  Volume: 11 Issue: 2 Pages: 442-449
- DOI
  10.1159/000490457
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07658, KAKENHI-PROJECT-15K19954
[Journal Article] LAPTM4B-35 is a novel prognostic factor for glioblastoma2017
- Author(s)
  Xiaoshud Dong, Kaoru Tamura, Daisuke Kobayashi, Noboru Ando, Kazutaka Sumita, Taketoshi Maehara
- Journal Title
  
  J Neurooncol
  
  Volume: 132 Issue: 2 Pages: 295-303
- DOI
  10.1007/s11060-017-2369-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19954
[Journal Article] Tumor Resection Recruits Effector T Cells and Boosts Therapeutic Efficacy of Encapsulated Stem Cells Expressing IFNβ in Glioblastomas2017
- Author(s)
  Choi SH, Stuckey DW, Pignatta S, Reinshagen C, Khalsa JK, Roozendaal N, Martinez-Quintanilla J, Tamura K, Keles E, Shah K
- Journal Title
  
  Clin Cancer Res
  
  Volume: 23 Issue: 22 Pages: 7047-7058
- DOI
  10.1158/1078-0432.ccr-17-0077
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19954
[Journal Article] ATRX Status Correlates with 11C-Methionine Uptake in WHO Grade II and III Gliomas with IDH1 Mutations2017
- Author(s)
  Takahiro Ogishima, Kaoru Tamura, Daisuke Kobayashi, Motoki Inaji, Shihori Hayashi, Reina Tamura, Tadashi Nariai, Kenji Ishii, Taketoshi Maehara
- Journal Title
  
  Brain Tumor Pathol
  
  Volume: 34 Issue: 1 Pages: 20-27
- DOI
  10.1007/s10014-017-0280-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19954
[Journal Article] Antiangiogenic variant of TSP-1 targets tumor cells in glioblastomas2015
- Author(s)
  Choi SH, Tamura K, Khajuria RK, Bhere D, Nesterenko I, Lawler J, Shah K
- Journal Title
  
  Molecular Therapy
  
  Volume: 23 Issue: 2 Pages: 235-43
- DOI
  10.1038/mt.2014.214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25861260, KAKENHI-PROJECT-15K19954
[Journal Article] Stem cells and the origin of different glioma subtypes. Response.2014
- Author(s)
  Tamura K, Aoyagi M
- Journal Title
  
  J Neurosurgy
  
  Volume: 120 Pages: 1010-1
- Data Source
  KAKENHI-PROJECT-25861260
[Journal Article] Stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy2014
- Author(s)
  Duebgen M, Martinez-Quintanilla J, Tamura K, Hingtgen S, Redjal N, Wakimoto H, Shah K
- Journal Title
  
  J Natl Cancer Inst
  
  Volume: 106 Issue: 6
- DOI
  10.1093/jnci/dju090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861260
[Journal Article] CD133-positive stem cells. Response.2014
- Author(s)
  Tamura K, Aoyagi M
- Journal Title
  
  J Neurosurgy
  
  Volume: 120 Pages: 1012-1012
- Data Source
  KAKENHI-PROJECT-25861260
[Journal Article] Multimchanistic tumor targeted oncolytic virus overcomes resistance in Brain tumors2013
- Author(s)
  Kaoru Tamura, Hiroaki Wakimoto, Aayush S Agarwal, Samuel D Rabkin, Deepak Bhere, Robert L Martuza, Toshihiko Kuroda, Randa Kasmieh, Khalid Shah
- Journal Title
  
  Molecular Therapy
  
  Volume: 21(1) Issue: 1 Pages: 6-77
- DOI
  10.1038/mt.2012.175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861260
[Journal Article] Expansion of CD133-positive glioma cells in recurrent de novo glioblastomas after radiation and chemotherapy2013
- Author(s)
  Kaoru Tamura, Masaru Aoyagi, Noboru Ando, Takahiro Ogishima , Hiroaki Wakimoto , Masaaki Yamamoto, Kikuo Ohno:
- Journal Title
  
  Journal of Neurosurgery
  
  Volume: 119 Issue: 5 Pages: 1145-1155
- DOI
  10.3171/2013.7.jns122417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861260
[Presentation] Analysis of 11C-methionine PET uptake and prognosis in lower grade gliomas2023
- Author(s)
  Tamura K, Inaji M, Yamamura T, Hara S, Shimizu K, Tanaka Y, Nariai T, Ishii K, Maehara T
- Organizer
  28th Annual Meeting of the Society for Neuro-Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08538
[Presentation] WHO新分類で分類不可能なIDH-wildtype lower grade gliomaのメチオニンPETと予後の検討2023
- Author(s)
  田村郁, 稲次基希,原祥子,山村俊弘、清水一秀,　田中洋次, 成相直, 石井賢二, 前原健寿
- Organizer
  日本脳神経外科学会第82回学術集会
- Data Source
  KAKENHI-PROJECT-23K08538
[Presentation] 当院の小児グリオーマ症例における2021WHO脳腫瘍分類に基づいた統合診断と臨床像2022
- Author(s)
  田村　郁、山村　俊弘、小林　大輔、菅原貴志、稲次　基希、田中　洋次、前原　健寿
- Organizer
  第50回日本小児神経外科学会
- Data Source
  KAKENHI-PROJECT-20K09321
[Presentation] 遺伝子変異で再分類したDiffuse gliomaにおけるMethionine PETの検討2022
- Author(s)
  田村郁、稲次基希、小林大輔、原祥子、唐鎌淳、菅原貴志、田中洋次、成相直、石井賢二
- Organizer
  第51回神経放射線学会
- Data Source
  KAKENHI-PROJECT-20K09321
[Presentation] 分子診断で再分類した神経膠腫におけるMethionine PETと治療経過の検討2021
- Author(s)
  田村郁, 稲次基希, 小林大輔, 原祥子、唐鎌淳、菅原貴志、田中洋次, 成相直, 石井賢二、前原健寿
- Organizer
  日本脳神経外科学会第80回学術総会
- Data Source
  KAKENHI-PROJECT-20K09321
[Presentation] 分子診断で再分類したDiffuse gliomaにおけるMethionine PETと治療経過の検討2021
- Author(s)
  田村郁, 稲次基希, 小林大輔, 原祥子, 唐鎌淳, 菅原貴志, 田中洋次, 成相直, 石井賢二, 前原健寿
- Organizer
  第39回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09321
[Presentation] 分子診断に基づいて再分類したグリオーマにおけるMethionine PETと臨床経過の検討2021
- Author(s)
  田村郁, 稲次基希, 小林大輔, 菅原貴志、田中洋次, 成相直, 石井賢二,前原健寿
- Organizer
  第44回日本脳神経CI学会総会
- Data Source
  KAKENHI-PROJECT-20K09321
[Presentation] 分子診断に基づいて再分類したグリオーマにおけるMethionine PETと臨床経過の検討2021
- Author(s)
  田村郁、稲次基希、小林大輔、菅原貴志、田中洋次、成相直、石井賢二、前原健寿
- Organizer
  第44回日本脳神経ＣＩ学会総会
- Data Source
  KAKENHI-PROJECT-20K09321
[Presentation] Analysis of pediatric gliomas in our institute2020
- Author(s)
  Kaoru Tamura, Mai Fujioka, Masae Kuroha, Motoki Inaji, Yoji Tanaka,Tadashi Nariai, Taketoshi Maehara
- Organizer
  The 19th International symposium on Pediatric Neuro-Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09321
[Presentation] 視床グリオーマにおけるH3K27M変異と11C-methionine-PET集積、臨床経過の検討2018
- Author(s)
  4.田村郁、稲次基希、小林大輔、平　直記、若林光、林志保里、工藤琢巳、壽美田一貴、田中洋次、成相直、石井賢二、前原健
- Organizer
  第36回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-15K19954
[Presentation] TRAIL分泌幹細胞とmicroRNAを用いた治療抵抗性グリオーマに対する新規治療法2018
- Author(s)
  田村郁, Deepak Bhere, Wakimoto Hiroaki, Choi Sung Hugh, Purow Benjamin, Debatisse Jeremy, Shah Khalid, 前原健寿
- Organizer
  第55回ニューロ・オンコロジィの会
- Data Source
  KAKENHI-PROJECT-15K19954
[Presentation] 治療抵抗性グリオーマに対するTRAILとmicroRNAを用いた新規治療法2018
- Author(s)
  田村郁, Deepak Bhere, Wakimoto Hiroaki, Choi Sung Hugh, Purow Benjamin, Debatisse Jeremy, Shah Khalid, 前原健寿
- Organizer
  第77回日本脳神経外科学会学術総会
- Data Source
  KAKENHI-PROJECT-15K19954
[Presentation] 膠芽腫におけるLAPTM4B-35の発現と予後因子としての意義2017
- Author(s)
  田村　郁、董　暁書、小林大輔、安藤登、壽美田一貴、前原健寿
- Organizer
  第35回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-15K19954
[Presentation] WHO2016改定分類に基づいた神経膠腫のintegrated diagnosisと[11C]methionine-PETの関係2017
- Author(s)
  田村郁、稲次基希、林志保里、荻島隆浩、成相直、石井賢二、豊原潤、前原健寿
- Organizer
  日本脳神経外科学会第76回学術総会
- Data Source
  KAKENHI-PROJECT-15K19954
[Presentation] ベバシズマブ投与後の膠芽腫の病理学的変化－初発時と剖検時の比較2015
- Author(s)
  田村郁、稲次基希、武川麻紀、折原あすみ、董暁書、木原淳、裴有安、前原健寿
- Organizer
  第33回日本脳腫瘍病理学会
- Place of Presentation
  JRホテルクレメント高松、高松
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-15K19954
[Presentation] Evaluation of the treatment response of malignant glioma on bevacizumab therapy using 11C-methionine positron emission tomography2015
- Author(s)
  Tamura, K., Inaji, M., Nariai, T., Hayashi, S., Tanaka, Y., Tamaki, M., Hirai, S., Saigusa, K., Ishii, K., Ishiwata, K., Maehara, T.
- Organizer
  20th Annual Scientfic Meeting of the Society for Neuro-Oncology
- Place of Presentation
  Texas, USA,
- Year and Date
  2015-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19954
[Presentation] 治療抵抗性グリオーマに対する幹細胞を用いた新規治療法2015
- Author(s)
  田村郁, Sung Hugh Choi, Rajiv Kumar Khajuria, Deepak Bhere,Irina Nesterenko, Jack Lawler, Khalid Shah, 前原健寿
- Organizer
  第74回日本脳神経外科学会
- Place of Presentation
  ロイトン札幌/さっぽろ芸術文化の館/札幌市教育文化会館、札幌
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-15K19954
[Presentation] 放射線治療後の悪性神経膠腫における腫瘍血管障害と腫瘍幹細胞の増殖2013
- Author(s)
  田村郁、青柳傑、安藤登、荻島隆浩、脇本浩明、山本昌昭、大野喜久郎、前原健寿
- Organizer
  第31回日本脳腫瘍学会学術集会
- Place of Presentation
  宮崎（フェニックス・シーガイア・リゾート）
- Data Source
  KAKENHI-PROJECT-25861260
[Presentation] Tumor vascular damage and glioma stem-like cell expansion after radiotherapy in malignant gliomas2013
- Author(s)
  Kaoru Tamura, Masaru Aoyagi, Noboru Ando, Takahiro Ogishima, Masaaki Yamamoto, Kikuo Ohno, Taketoshi Maehara
- Organizer
  4th Quadrennial meeting of the World Federation of Neuro-Oncology Meeting and the 18th Annual Scientific Meeting of the Society for Neuro-Oncology
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-25861260
[Presentation] Malignant gliomaにおけるBevacizumabの抗腫瘍効果のMethionin-PETによる検討
- Author(s)
  田村　郁、稲次基希、成相直、玉置正史、平井作京、三枝邦康、田中洋次、前原健寿
- Organizer
  第73回日本脳神経外科学会総会　東京
- Place of Presentation
  東京
- Year and Date
  2014-10-09 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-25861260
[Presentation] Monitoring of biological response to bevacizumab in malignant glioma patients based on L-[methyl-11C] methionine-positron emission tomography
- Author(s)
  Tamura K., Inaji M., Nariai T., Tamaki M., Hirai S., Saigusa K., Tanaka Y., Maehara T.
- Organizer
  19th Annual Scientific Meeting of the Society for Neuro-Oncology
- Place of Presentation
  Florida, USA
- Year and Date
  2014-11-13 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25861260

1. 佐々木雄彦 (50333365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 内藤瑞 (50755329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 持田祐希 (60739134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 吉岡耕太郎 (70780641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 中村乃理子 (80910174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHAH Khalid

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. WAKIMOTO Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. FURUHASHI Yaeko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TOYOHARA Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tamura Kaoru 田村 郁

TAMURA Kaoru 田村 郁

Research Projects

Research Products

Co-Researchers

Size-tunable drug delivery systems for their application to X-ray therapy for brain tumors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規計測技術による腫瘍制御性リン脂質代謝系の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂質代謝をターゲットとした悪性脳腫瘍の治療抵抗性機序の解明とその克服Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapy and biomarkers for malignant brain tumors based on microRNA analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New treatment strategy for resistant brain tumors targeting brain tumor stem cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Combination therapy with micro RNA and therapeutic stem cells expressing TRAIL overcomes resistant brain tumorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Correlation of Intraoperative 5-ALA-Induced Fluorescence Intensity and Preoperative 11C-Methionine PET Uptake in Glioma Surgery2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ischemic Stroke with Multiple Cerebral Artery Stenosis in a Patient with an Anaplastic Astrocytoma during Bevacizumab Treatment: A Case Report2022

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 症例 放射線照射3年6カ月後に発症したradiation-induced meningiomaの1例2018

Author(s)

Journal Title

DOI

ISSN

Year and Date

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[Journal Article] Usefulness of <sup>11</sup>C-Methionine Positron Emission Tomography for Monitoring of Treatment Response and Recurrence in a Glioblastoma Patient on Bevacizumab Therapy: A Case Report2018

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[Journal Article] LAPTM4B-35 is a novel prognostic factor for glioblastoma2017

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[Journal Article] Tumor Resection Recruits Effector T Cells and Boosts Therapeutic Efficacy of Encapsulated Stem Cells Expressing IFNβ in Glioblastomas2017

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Tamura Kaoru 田村郁

TAMURA Kaoru 田村郁

[Journal Article] 症例放射線照射3年6カ月後に発症したradiation-induced meningiomaの1例2018

[Presentation] WHO新分類で分類不可能なIDH-wildtype lower grade gliomaのメチオニンPETと予後の検討2023