Nakashima Kenichi 中島健一

… Alternative Names

Nakashima Ken-ichi 中島健一

NAKASHIMA Ken-ichi 中島健一

NAKASHIMA Kenichi 中島健一

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Researcher Number	70635135
Other IDs
Affiliation (Current)	2025: 愛知学院大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2025: 愛知学院大学, 薬学部, 教授 2023: 愛知学院大学, 薬学部, 教授 2020 – 2022: 愛知学院大学, 薬学部, 准教授 2018 – 2019: 愛知学院大学, 薬学部, 講師 2016: 愛知学院大学, 薬学部, 助教 2013: 愛知学院大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related Except Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Natural medicines / Biological pharmacy
Keywords	Principal Investigator 天然物化学 / 植物内生菌 / エンドファイト / 天然物 / mRNAシーケンス / 生理活性天然物 / 核内受容体 / mRNA-seq / 天然有機化合物 / 二次代謝産物 … More / 有用資源探索 / 真菌 / セスキテルペノイド / ポリケタイド … More Except Principal Investigator 天然物 / 生活習慣病 / ベージュ脂肪細胞 / 時計遺伝子 / 皮膚炎 / インスリン抵抗性 / 天然由来アゴニスト / 抗炎症作用 / 天然生理活性物質 / 核内受容体 / レチノイドX受容体 / MexXY(-OprA) / 多剤排出ポンプ / 多剤耐性緑膿菌 Less

NLRP3インフラマソームを標的とした天然由来抗炎症活性成分の探索Principal Investigator
- Principal Investigator
  
  中島健一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Aichi Gakuin University
mRNAシーケンスを用いたエンドファイト由来機能性物質の効率的な探索Principal Investigator
- Principal Investigator
  
  中島健一
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Aichi Gakuin University
Development of natural products based on regulation of biological clock system
- Principal Investigator
  
  Hirai Takao
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Ishikawa Prefectural Nursing University
  Aichi Gakuin University
Elucidation of the ecology of plant endophytic fungi by natural product chemistry and approaches to their utilization as useful resourcesPrincipal Investigator
- Principal Investigator
  
  Nakashima Ken-ichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Aichi Gakuin University
Application of naturally occurring retinoid X receptor agonists to lifestyle-related diseases and inflammatory diseases
- Principal Investigator
  
  INOUE Makoto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Aichi Gakuin University
Metagenomic approach to identify agents to restore anti-pseudomonas drugs against multidrug resistant Pseudomonas aeruginosa (MDRP): use of MDRP mutants lacking multidrug efflux pumps.
- Principal Investigator
  
  MORITA Yuji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Aichi Gakuin University

All 2023 2022 2021 2020 2019 2018 2016 2015 2014 2013

All Journal Article Presentation Patent

[Journal Article] Sulfur-containing spiroketals from <i>Breynia disticha</i> and evaluations of their anti-inflammatory effect2023
- Author(s)
  Nakashima Ken-ichi、Abe Naohito、Oyama Masayoshi、Murata Hiroko、Inoue Makoto
- Journal Title
  
  Beilstein Journal of Organic Chemistry
  
  Volume: 19 Pages: 1604-1614
- DOI
  10.3762/bjoc.19.117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06622
[Journal Article] Two new ?-pyrone derivatives from the endophytic Diaporthe sp. ECN3712022
- Author(s)
  Nakashima Ken-ichi、Higuchi Yuka、Tomida Junko、Kawamura Yoshiaki、Inoue Makoto
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 76 Issue: 2 Pages: 462-467
- DOI
  10.1007/s11418-021-01586-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06622
[Journal Article] Transmembrane G protein-coupled receptor 5 signaling stimulates fibroblast growth factor 21 expression concomitant with up-regulation of the transcription factor nuclear receptor Nr4a12021
- Author(s)
  Kiyama Genki、Nakashima Ken-ichi、Shimada Kazumasa、Murono Naoko、Kakihana Wataru、Imai Hideki、Inoue Makoto、Hirai Takao
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 142 Pages: 112078-112078
- DOI
  10.1016/j.biopha.2021.112078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07154
[Journal Article] A New Chromone Derivative from Endophytic Fungus Xylaria sp. ECN2122021
- Author(s)
  Nakashima Ken-ichi、Tomida Junko、Kawamura Yoshiaki、Inoue Makoto
- Journal Title
  
  Heterocycles
  
  Volume: 102 Issue: 5 Pages: 955-955
- DOI
  10.3987/com-21-14427
- NAID
  40022572830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14939
[Journal Article] Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale2020
- Author(s)
  Nakashima Ken-ichi、Tomida Junko、Tsuboi Tomoe、Kawamura Yoshiaki、Inoue Makoto
- Journal Title
  
  Beilstein Journal of Organic Chemistry
  
  Volume: 16 Pages: 2100-2107
- DOI
  10.3762/bjoc.16.177
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14939
[Journal Article] Absolute configurations of talaromycones A and B, α-diversonolic ester, and aspergillusone B from endophytic Talaromyces sp. ECN2112020
- Author(s)
  Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura, Makoto Inoue
- Journal Title
  
  Beilstein Journal of Organic Chemistry
  
  Volume: 16 Pages: 290-296
- DOI
  10.3762/bjoc.16.28
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14939
[Journal Article] Paraconiothins A-J: Sesquiterpenoids from the Endophytic Fungus Paraconiothyrium brasiliense ECN2582019
- Author(s)
  Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura, Makoto Inoue
- Journal Title
  
  Journal of Natural Products
  
  Volume: 82 Issue: 12 Pages: 3347-3356
- DOI
  10.1021/acs.jnatprod.9b00638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14939
[Journal Article] Sesquiterpenes with new carbon skeletons from the basidiomycete Phlebia tremellosa2019
- Author(s)
  Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura, Makoto Inoue
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 73 Issue: 3 Pages: 480-486
- DOI
  10.1007/s11418-019-01286-8
- NAID
  40021912583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14939
[Journal Article] Berberine stimulates fibroblast growth factor 21 by modulating the molecular clock component brain and muscle Arnt-like 1 in brown adipose tissue.2019
- Author(s)
  Hirai T, Mitani Y, Kurumisawa K, Nomura K, Wang W, Nakashima KI, Inoue M
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 164 Pages: 165-176
- DOI
  10.1016/j.bcp.2019.04.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07154
[Journal Article] Evaluation of Naturally Occurring Compounds Regulating Brown/Beige Adipocyte Differentiation2019
- Author(s)
  Hirai T, Takagi M, Nakashima KI, Inoue M
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 139 Issue: 6 Pages: 861-866
- DOI
  10.1248/yakushi.18-00173-3
- NAID
  130007657089
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2019-06-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07154
[Journal Article] Yuccalides A-C, three new phenolic compounds with spiro-structures from the roots of Yucca gloriosa.2016
- Author(s)
  Ken-ichi Nakashima, Naohito Abe, Masayoshi Oyama, Makoto Inoue.
- Journal Title
  
  Fitoterapia
  
  Volume: 111 Pages: 154-159
- DOI
  10.1016/j.fitote.2016.04.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460134
[Journal Article] Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene.2014
- Author(s)
  Inoue M, Tanabe H, Nakashima K, Ishida Y, Kotani H.
- Journal Title
  
  J Nat Prod.
  
  Volume: 25;77(7) Issue: 7 Pages: 1670-7
- DOI
  10.1021/np5002016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460132, KAKENHI-PROJECT-26460134
[Journal Article] Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis2014
- Author(s)
  Ken-ichi Nakashima, Tohru Murakami, Hiroki Tanabe, Makoto Inoue
- Journal Title
  
  Biochimica et Biophysica Acta-General Subjects
  
  Volume: 1840 Pages: 3034-3041
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460134
[Patent] レチノイドX受容体アゴニスト剤2014
- Inventor(s)
  井上誠，中島健一，田邊宏樹，池野久美子，中村正
- Industrial Property Rights Holder
  井上誠，中島健一，田邊宏樹，池野久美子，中村正
- Industrial Property Rights Type
  特許
- Filing Date
  2014-10-10
- Acquisition Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-26460134
[Patent] 抗菌薬耐性阻害剤2013
- Inventor(s)
  森田雄二、中島健一、富田純子、田邊宏樹、井上誠、河村好章
- Industrial Property Rights Holder
  森田雄二、中島健一、富田純子、田邊宏樹、井上誠、河村好章
- Industrial Property Rights Type
  特許
- Filing Date
  2013-08-01
- Data Source
  KAKENHI-PROJECT-23790106
[Patent] 抗菌薬耐性阻害剤2013
- Inventor(s)
  森田雄二、中島健一、富田純子、田邉宏樹、井上誠、河村好章
- Industrial Property Rights Holder
  森田雄二、中島健一、富田純子、田邉宏樹、井上誠、河村好章
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-160441
- Filing Date
  2013-08-01
- Data Source
  KAKENHI-PROJECT-23790106
[Presentation] ミカン科マツカゼソウの成分に関する研究2023
- Author(s)
  中島健一、仲間雄大、井上誠
- Organizer
  日本生薬学会第69回年会（仙台）
- Data Source
  KAKENHI-PROJECT-21K06622
[Presentation] ヨウシュコバンノキ由来含硫スピロケタール誘導体の抗炎症作用2022
- Author(s)
  中島健一、阿部尚仁、船戸乃吏佳、坪井知恵、邑田裕子、大山雅義、井上誠
- Organizer
  第68回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06622
[Presentation] ヨウシュコバンノキより単離した含硫スピロケタール誘導体の構造解析2022
- Author(s)
  中島健一、阿部尚仁、坪井知恵、邑田裕子、大山雅義、井上誠
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06622
[Presentation] 植物内生真菌Muyocopronon lateraleから単離した新規アザフィロンの構造解析2021
- Author(s)
  中島健一、富田純子、坪井知恵、河村好章、井上誠
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K14939
[Presentation] レンギョウによる代謝調節因子FGF21の発現促進作用に関する研究2020
- Author(s)
  来山元規，平居貴生，嶋田一優，中島健一，井上誠
- Organizer
  第３７回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07154
[Presentation] Fibroblast growth factor 21を制御する天然物の概日時計制御系への影響2019
- Author(s)
  平居貴生、中島健一、井上誠
- Organizer
  第35回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07154
[Presentation] 植物内生真菌Paraconiothyrium brasilienseが産生する新規セスキテルペノイドに関する研究(2)2019
- Author(s)
  中島健一、富田純子、平居貴生、河村好章、井上誠.
- Organizer
  日本生薬学会第66回年会
- Data Source
  KAKENHI-PROJECT-18K14939
[Presentation] 植物内生真菌Paraconiothyrium brasilienseが産生する新規セスキテルペノイドに関する研究(2)2019
- Author(s)
  中島健一、富田純子、平居貴生、河村好章、井上誠
- Organizer
  日本生薬学会第65回年会
- Data Source
  KAKENHI-PROJECT-19K07154
[Presentation] New sesquiterpenoids from an endophytic fungus Paraconiothyrium brasiliense ECN2582019
- Author(s)
  Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura, Makoto Inoue
- Organizer
  67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research
- Data Source
  KAKENHI-PROJECT-19K07154
[Presentation] 植物内生菌Paraconiothyrium sp.が産生する新規セスキテルペン2019
- Author(s)
  中島健一、富田純子、平居貴生、河村好章、井上誠
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K14939
[Presentation] New sesquiterpenoids from an endophytic fungus Paraconiothyrium brasiliense ECN258.2019
- Author(s)
  Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura, Makoto Inoue
- Organizer
  GA2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14939
[Presentation] Xylaria属植物内生真菌が産生する新規セスキテルペンのNF-κB阻害作用2018
- Author(s)
  中島健一、野尻悠斗、富田純子、平居貴生、河村好章、井上誠
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2018
- Data Source
  KAKENHI-PROJECT-18K14939
[Presentation] 植物内生菌Talaromyces sp. ECN211株から単離した新規ポリケタイドに関する研究2018
- Author(s)
  中島健一、富田純子、平居貴生、河村好章、井上誠
- Organizer
  日本生薬学会第65回年会
- Data Source
  KAKENHI-PROJECT-18K14939
[Presentation] サンズコン由来RXRアゴニストのMetallothionein誘導作用に関する研究2016
- Author(s)
  王蔚，中島健一，井上誠
- Organizer
  日本生薬学会第63回年会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2016-09-24
- Data Source
  KAKENHI-PROJECT-26460134
[Presentation] サンズコン由来RXRアゴニストprenylflavanonesの抗炎症作用（２）2016
- Author(s)
  王蔚，中島健一，井上誠
- Organizer
  第62回日本薬学会東海支部総会・大会
- Place of Presentation
  愛知学院大学薬学部（愛知県・名古屋市）
- Year and Date
  2016-07-11
- Data Source
  KAKENHI-PROJECT-26460134
[Presentation] サンズコン由来RXRアゴニストにより誘導される抗炎症作用関連遺伝子の発現解析2015
- Author(s)
  王　蔚、中島健一、田邊宏樹、井上　誠
- Organizer
  日本生薬学会第62回年会
- Place of Presentation
  長良川国際会議場（岐阜市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26460134
[Presentation] Drupanin is naturally occurring retinoid X receptor agonist from Brazilian green propolis2014
- Author(s)
  Ken-ichi Nakashima, Toshiyuki Tanaka, Hiroko Murata, Kouichi Kaburagi, Makoto Inoue
- Organizer
  The American Society of Pharmacognosy 2014 annual meeting
- Place of Presentation
  Mississippi, USA
- Year and Date
  2014-08-04
- Data Source
  KAKENHI-PROJECT-26460134
[Presentation] 生薬由来成分による緑膿菌のマクロライド・リンコマイシン系薬耐性阻害とそのメカニズムについて2014
- Author(s)
  小嶋悠希、森田雄二、中島健一、富田純子、田邉宏樹、井上誠、河村好章
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-23790106
[Presentation] サンズコン由来RXRアゴニストprenylflavanonesの抗炎症作用2014
- Author(s)
  王　蔚、中島健一、田邊宏樹、井上誠
- Organizer
  日本生薬学会第61回年会
- Place of Presentation
  福岡
- Year and Date
  2014-09-14
- Data Source
  KAKENHI-PROJECT-26460134
[Presentation] 多剤耐性緑膿菌の抗菌薬耐性系阻害物質の探索とその解析2014
- Author(s)
  森田雄二、小嶋悠希、中島健一、富田純子、田邉宏樹、井上誠、河村好章
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-23790106
[Presentation] 生薬由来成分による緑膿菌のマクロライド・リンコマイシン系薬耐性阻害とそのメカニズムについて2014
- Author(s)
  小嶋悠希，森田雄二，中島健一，富田純子，田邉宏樹，井上　誠，河村好章
- Organizer
  日本薬学会　第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790106
[Presentation] 多剤耐性緑膿菌の抗菌薬耐性系阻害物質の探索とその解析2014
- Author(s)
  森田雄二，小嶋悠希，中島健一，富田純子，田邉宏樹，井上　誠，河村好章
- Organizer
  日本薬学会　第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790106

1. TANABE Hiroki (10415606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. TOMIDA Junko (10454323)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. INOUE Makoto (50191888)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. MORITA Yuji (00454322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. KAWAMURA Yoshiaki (80262757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Hirai Takao (80389072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. KOJIMA Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. KUSU Akane

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKAGI Michiyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OH I

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. KOTANI Hitoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 川村好章

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Nakashima Kenichi 中島 健一

Nakashima Ken-ichi 中島 健一

NAKASHIMA Ken-ichi 中島 健一

NAKASHIMA Kenichi 中島 健一

Research Projects

Research Products

Co-Researchers

NLRP3インフラマソームを標的とした天然由来抗炎症活性成分の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

mRNAシーケンスを用いたエンドファイト由来機能性物質の効率的な探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of natural products based on regulation of biological clock system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the ecology of plant endophytic fungi by natural product chemistry and approaches to their utilization as useful resourcesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Application of naturally occurring retinoid X receptor agonists to lifestyle-related diseases and inflammatory diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Metagenomic approach to identify agents to restore anti-pseudomonas drugs against multidrug resistant Pseudomonas aeruginosa (MDRP): use of MDRP mutants lacking multidrug efflux pumps.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sulfur-containing spiroketals from <i>Breynia disticha</i> and evaluations of their anti-inflammatory effect2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two new ?-pyrone derivatives from the endophytic Diaporthe sp. ECN3712022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transmembrane G protein-coupled receptor 5 signaling stimulates fibroblast growth factor 21 expression concomitant with up-regulation of the transcription factor nuclear receptor Nr4a12021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A New Chromone Derivative from Endophytic Fungus Xylaria sp. ECN2122021

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NAID

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[Journal Article] Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale2020

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DOI

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[Journal Article] Absolute configurations of talaromycones A and B, α-diversonolic ester, and aspergillusone B from endophytic Talaromyces sp. ECN2112020

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[Journal Article] Paraconiothins A-J: Sesquiterpenoids from the Endophytic Fungus Paraconiothyrium brasiliense ECN2582019

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[Journal Article] Sesquiterpenes with new carbon skeletons from the basidiomycete Phlebia tremellosa2019

Nakashima Kenichi 中島健一

Nakashima Ken-ichi 中島健一

NAKASHIMA Ken-ichi 中島健一

NAKASHIMA Kenichi 中島健一