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Akiyama Yasutoshi  秋山 泰利

… Alternative Names

AKIYAMA Yasutoshi  秋山 泰利

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Researcher Number 70635557
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-0211-7793
Affiliation (Current) 2025: 東北大学, 薬学研究科, 助教
Affiliation (based on the past Project Information) *help 2020 – 2024: 東北大学, 薬学研究科, 助教
2023: 東北大学, 薬学研究科(研究院), 助教
2016: 東北大学, 医学系研究科, 非常勤講師
2015: 東北大学, 医学(系)研究科(研究院), 大学院非常勤講師
2014: 東北大学, 東北メディカル・メガバンク機構, 助教
2013: 東北大学, 東北メディカル・メガバンク機構, 非常勤講師
2012: 東北大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Basic Section 49010:Pathological biochemistry-related / Medical pharmacy
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords
Principal Investigator
iPS細胞 / ミトコンドリア病 / tRNA / 尿毒素 / 糖尿病 / ストレス応答 / tRNAs / LC-MS/MS / 修飾核酸 / MELAS … More / 腸内細菌叢 / 血液透析 / 慢性腎不全 / MA-5 / ミトコンドリア / 腸内細菌 / 尿毒症物質 / インドキシル硫酸 / SLCO4C1 / 慢性腎臓病 / 尿毒症 / トランスポーター … More
Except Principal Investigator
CD73 / がん治療 / 内在化機構 / 低分子化合物 / 免疫制御 / アデノシン / CD39 / CD73 / 免疫抑制 / 化合物ライブラリー / エクソソーム / compound library / inhibitors / CD39 Less
  • Research Projects

    (6 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (4 People)
  •  疾患iPS細胞とストレス応答機構から迫るミトコンドリア病の病態解明Principal Investigator

    • Principal Investigator
      秋山 泰利
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Tohoku University
  •  Study of CD73 internalization mechanism by low-molecular-weight compounds and development of anti-cancer drugs

    • Principal Investigator
      富岡 佳久
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Tohoku University
  •  Profiling of modified nucleosides in mitochondrial tRNAs for diagnosis of mitochondrial diseasesPrincipal Investigator

    • Principal Investigator
      Akiyama Yasutoshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Tohoku University
  •  Search for molecules that control the CD39-CD73-adenosine cascade and expand into drug discovery

    • Principal Investigator
      Tomioka Yoshihisa
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Tohoku University
  •  Kidney transporter and gut microbiota as therapeutic targets for chronic kidney diseasePrincipal Investigator

    • Principal Investigator
      Akiyama Yasutoshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Regulation of SLCO4C1 transporter-mediated excretion of uremic toxins as a therapeutic strategy for Chronic Kidney DiseasePrincipal Investigator

    • Principal Investigator
      AKIYAMA Yasutoshi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University

All 2023 2022 2017 2015 2014 2013 2012 Other

All Journal Article Presentation Book Other

  • [Book] 慢性腎不全の病態トピックス9トランスポーター, 腎不全治療レシピ, 査読なし2013

    • Author(s)
      秋山泰利、阿部高明
    • Publisher
      医学出版
    • Data Source
      KAKENHI-PROJECT-24890013
  • [Book] Annual Review腎臓2013

    • Author(s)
      秋山 泰利
    • Total Pages
      9
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-24890013
  • [Journal Article] tRNA‐derived RNAs: Biogenesis and roles in translational control2023

    • Author(s)
      Akiyama Yasutoshi、Ivanov Pavel
    • Journal Title

      WIREs RNA

      Volume: 14 Issue: 6

    • DOI

      10.1002/wrna.1805

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06865
  • [Journal Article] CD98 regulates the phosphorylation of HER2 and a bispecific anti‐HER2/CD98 antibody inhibits the growth signal of human breast cancer cells2023

    • Author(s)
      Yamasaki Akitaka、Maruyama‐Takahashi Kumiko、Nishida Kento、Okazaki Shogo、Okita Kouki、Akiyama Yasutoshi、Suzuki Hideaki、Endo Yuichi、Masuko Kazue、Masuko Takashi、Tomioka Yoshihisa
    • Journal Title

      Genes to Cells

      Volume: - Issue: 5 Pages: 374-382

    • DOI

      10.1111/gtc.13016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06865, KAKENHI-PROJECT-22K07157, KAKENHI-PLANNED-18H05463
  • [Journal Article] Oxidative Stress, Transfer RNA Metabolism, and Protein Synthesis2023

    • Author(s)
      Akiyama Yasutoshi、Ivanov Pavel
    • Journal Title

      Antioxidants & Redox Signaling

      Volume: - Issue: 10-12 Pages: 715-735

    • DOI

      10.1089/ars.2022.0206

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06865
  • [Journal Article] Dual‐targeting therapy against HER3/MET in human colorectal cancers2023

    • Author(s)
      Yamasaki Akitaka、Miyake Rikuto、Hara Yuta、Okuno Hideki、Imaida Takuya、Okita Kouki、Okazaki Shogo、Akiyama Yasutoshi、Hirotani Kenji、Endo Yuichi、Masuko Kazue、Masuko Takashi、Tomioka Yoshihisa
    • Journal Title

      Cancer Medicine

      Volume: - Issue: 8 Pages: 9684-9696

    • DOI

      10.1002/cam4.5673

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06865, KAKENHI-PROJECT-22K07157, KAKENHI-PLANNED-18H05463
  • [Journal Article] Selective Cleavage at CCA Ends and Anticodon Loops of tRNAs by Stress-Induced RNases2022

    • Author(s)
      Akiyama Yasutoshi、Lyons Shawn M.、Fay Marta M.、Tomioka Yoshihisa、Abe Takaaki、Anderson Paul J.、Ivanov Pavel
    • Journal Title

      Frontiers in Molecular Biosciences

      Volume: 9

    • DOI

      10.3389/fmolb.2022.791094

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06865
  • [Journal Article] RTCB Complex Regulates Stress-Induced tRNA Cleavage2022

    • Author(s)
      Akiyama Yasutoshi、Takenaka Yoshika、Kasahara Tomoko、Abe Takaaki、Tomioka Yoshihisa、Ivanov Pavel
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 21 Pages: 13100-13100

    • DOI

      10.3390/ijms232113100

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06865
  • [Journal Article] RNA biology of angiogenin: Current state and perspectives2017

    • Author(s)
      Shawn M Lyons, Marta M Fay, Yasutoshi Akiyama, Paul J Anderson, and Pavel Ivanov
    • Journal Title

      RNA Biology

      Volume: 14 Issue: 2 Pages: 171-178

    • DOI

      10.1080/15476286.2016.1272746

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26860094
  • [Journal Article] Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases.2015

    • Author(s)
      T Suzuki, H Yamaguchi, M Kikusato, (他11名), Y Akiyama, Y Takeuchi, A Yuri, K Kikuchi, T Toyohara, C Suzuki, M Kohzuki, J Anzai, N Mano, S Kure, T Yanagisawa, Y Tomioka, M Toyomizu, S Ito, H Osaka, K Hayashi, and T Abe
    • Journal Title

      Tohoku J Exp Med

      Volume: 236 Pages: 225-232

    • NAID

      130005083526

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26860094
  • [Journal Article] Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD2014

    • Author(s)
      Eikan Mishima, Shinji Fukuda, Hisato Shima, Akiyoshi Hirayama, Yasutoshi Akiyama, Yoichi Takeuchi, Noriko N Fukuda, Takehiro Suzuki, Chitose Suzuki, Akinori Yuri, Koichi Kikuchi, Yoshihisa Tomioka, Sadayoshi Ito, Tomoyoshi Soga, and Takaaki Abe
    • Journal Title

      J Am Soc Nephrol

      Volume: 26 Issue: 8 Pages: 1-8

    • DOI

      10.1681/asn.2014060530

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26860094, KAKENHI-PROJECT-26860624, KAKENHI-PROJECT-26293031, KAKENHI-PROJECT-26305007
  • [Journal Article] 尿毒素の輸送とCKD2013

    • Author(s)
      2.秋山泰利、阿部高明
    • Journal Title

      腎と骨代謝

      Volume: 26 Pages: 223-229

    • Data Source
      KAKENHI-PROJECT-24890013
  • [Journal Article] Carrier-mediated transport of quercetin conjugates : Involvement of organic anion transporters and organic anion transporting polypeptides2012

    • Author(s)
      Wong C, Akiyama Y, Abe T et al.
    • Journal Title

      Biochem. Pharmacol

      Volume: 84 Issue: 4 Pages: 564-570

    • DOI

      10.1016/j.bcp.2012.05.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890013
  • [Journal Article] A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS).2012

    • Author(s)
      Akiyama Y.
    • Journal Title

      Toxins

      Volume: 4 Issue: 11 Pages: 1309-1322

    • DOI

      10.3390/toxins4111309

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390033, KAKENHI-PROJECT-24390211, KAKENHI-PROJECT-24590177, KAKENHI-PROJECT-24659062, KAKENHI-PROJECT-24890013
  • [Presentation] Cytoplasmic processing of human transfer RNAs2022

    • Author(s)
      秋山泰利、阿部高明、富岡佳久、Pavel Ivanov
    • Organizer
      第23回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-21K06865
  • [Presentation] RTCB ligase complex regulates stress-induced tRNA cleavage2022

    • Author(s)
      竹中慶香、秋山泰利、松本洋太郎、富岡佳久
    • Organizer
      第23回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-21K06865
  • [Presentation] CE-MSによる透析患者に特異的な尿毒素の網羅的探索2015

    • Author(s)
      秋山泰利
    • Organizer
      日本透析医学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2015-06-26
    • Data Source
      KAKENHI-PROJECT-26860094
  • [Presentation] Indole-3-acetate Inhibits Erythropoietin Receptor Expression and Erythropoietin Signaling in vitro2013

    • Author(s)
      秋山 泰利
    • Organizer
      アメリカ腎臓学会
    • Place of Presentation
      アメリカ アトランタ
    • Data Source
      KAKENHI-PROJECT-24890013
  • [Presentation] A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS)2012

    • Author(s)
      秋山泰利
    • Place of Presentation
      アメリカ腎臓学会
    • Data Source
      KAKENHI-PROJECT-24890013
  • [Presentation] Metabolomic approach for clarifying the effect of AST-120 in 5/6 nephrectomized rats by capillary electrophoresis mass spectrometry2012

    • Author(s)
      秋山 泰利
    • Organizer
      アメリカ腎臓学会
    • Place of Presentation
      アメリカ サンディエゴ
    • Data Source
      KAKENHI-PROJECT-24890013
  • [Presentation] CE-MSによる透析患者に特異的な尿毒素の網羅的探索

    • Author(s)
      秋山泰利
    • Organizer
      日本透析医学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-06-26 – 2015-06-28
    • Data Source
      KAKENHI-PROJECT-26860094
  • []

  • []

  • 1.  Tomioka Yoshihisa (00282062)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  塚本 宏樹 (70423605)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  松本 洋太郎 (90420041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  豊原 敬文 (60594182)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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