Akiyama Yasutoshi 秋山泰利

… Alternative Names

AKIYAMA Yasutoshi 秋山泰利

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Researcher Number	70635557
Other IDs	https://orcid.org/0000-0002-0211-7793
Affiliation (Current)	2025: 東北大学, 薬学研究科, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 東北大学, 薬学研究科, 助教 2023: 東北大学, 薬学研究科(研究院), 助教 2016: 東北大学, 医学系研究科, 非常勤講師 2015: 東北大学, 医学(系)研究科(研究院), 大学院非常勤講師 2014: 東北大学, 東北メディカル・メガバンク機構, 助教 2013: 東北大学, 東北メディカル・メガバンク機構, 非常勤講師 2012: 東北大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Medical pharmacy Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator tRNA / iPS細胞 / ミトコンドリア病 / 尿毒素 / 糖尿病 / ストレス応答 / tRNAs / LC-MS/MS / 修飾核酸 / MELAS … More / 腸内細菌叢 / 血液透析 / 慢性腎不全 / MA-5 / ミトコンドリア / 腸内細菌 / 尿毒症物質 / インドキシル硫酸 / SLCO4C1 / 慢性腎臓病 / 尿毒症 / トランスポーター … More Except Principal Investigator CD73 / がん治療 / 内在化機構 / 低分子化合物 / 免疫制御 / アデノシン / ＣＤ３９ / ＣＤ７３ / 免疫抑制 / 化合物ライブラリー / エクソソーム / compound library / inhibitors / CD39 Less

疾患iPS細胞とストレス応答機構から迫るミトコンドリア病の病態解明Principal Investigator
- Principal Investigator
  
  秋山泰利
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tohoku University
Study of CD73 internalization mechanism by low-molecular-weight compounds and development of anti-cancer drugs
- Principal Investigator
  
  富岡佳久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Profiling of modified nucleosides in mitochondrial tRNAs for diagnosis of mitochondrial diseasesPrincipal Investigator
- Principal Investigator
  
  Akiyama Yasutoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tohoku University
Search for molecules that control the CD39-CD73-adenosine cascade and expand into drug discovery
- Principal Investigator
  
  Tomioka Yoshihisa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Kidney transporter and gut microbiota as therapeutic targets for chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Akiyama Yasutoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Regulation of SLCO4C1 transporter-mediated excretion of uremic toxins as a therapeutic strategy for Chronic Kidney DiseasePrincipal Investigator
- Principal Investigator
  
  AKIYAMA Yasutoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University

All 2025 2023 2022 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] 慢性腎不全の病態トピックス9トランスポーター, 腎不全治療レシピ, 査読なし2013
- Author(s)
  秋山泰利、阿部高明
- Publisher
  医学出版
- Data Source
  KAKENHI-PROJECT-24890013
[Book] Annual Review腎臓2013
- Author(s)
  秋山　泰利
- Total Pages
  9
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-24890013
[Journal Article] RNase L Produces tRNA-derived RNAs that Contribute to Translation Inhibition2025
- Author(s)
  Takenaka Y, Yamada A, Tomioka Y, Akiyama Y and Ivanov P.
- Journal Title
  
  RNA
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23KK0290
[Journal Article] tRNA‐derived RNAs: Biogenesis and roles in translational control2023
- Author(s)
  Akiyama Yasutoshi、Ivanov Pavel
- Journal Title
  
  WIREs RNA
  
  Volume: 14 Issue: 6
- DOI
  10.1002/wrna.1805
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06865
[Journal Article] CD98 regulates the phosphorylation of HER2 and a bispecific anti‐HER2/CD98 antibody inhibits the growth signal of human breast cancer cells2023
- Author(s)
  Yamasaki Akitaka、Maruyama‐Takahashi Kumiko、Nishida Kento、Okazaki Shogo、Okita Kouki、Akiyama Yasutoshi、Suzuki Hideaki、Endo Yuichi、Masuko Kazue、Masuko Takashi、Tomioka Yoshihisa
- Journal Title
  
  Genes to Cells
  
  Volume: - Issue: 5 Pages: 374-382
- DOI
  10.1111/gtc.13016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06865, KAKENHI-PROJECT-22K07157, KAKENHI-PLANNED-18H05463
[Journal Article] Oxidative Stress, Transfer RNA Metabolism, and Protein Synthesis2023
- Author(s)
  Akiyama Yasutoshi、Ivanov Pavel
- Journal Title
  
  Antioxidants & Redox Signaling
  
  Volume: - Issue: 10-12 Pages: 715-735
- DOI
  10.1089/ars.2022.0206
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06865
[Journal Article] Dual‐targeting therapy against HER3/MET in human colorectal cancers2023
- Author(s)
  Yamasaki Akitaka、Miyake Rikuto、Hara Yuta、Okuno Hideki、Imaida Takuya、Okita Kouki、Okazaki Shogo、Akiyama Yasutoshi、Hirotani Kenji、Endo Yuichi、Masuko Kazue、Masuko Takashi、Tomioka Yoshihisa
- Journal Title
  
  Cancer Medicine
  
  Volume: - Issue: 8 Pages: 9684-9696
- DOI
  10.1002/cam4.5673
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06865, KAKENHI-PROJECT-22K07157, KAKENHI-PLANNED-18H05463
[Journal Article] Selective Cleavage at CCA Ends and Anticodon Loops of tRNAs by Stress-Induced RNases2022
- Author(s)
  Akiyama Yasutoshi、Lyons Shawn M.、Fay Marta M.、Tomioka Yoshihisa、Abe Takaaki、Anderson Paul J.、Ivanov Pavel
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 9
- DOI
  10.3389/fmolb.2022.791094
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06865
[Journal Article] RTCB Complex Regulates Stress-Induced tRNA Cleavage2022
- Author(s)
  Akiyama Yasutoshi、Takenaka Yoshika、Kasahara Tomoko、Abe Takaaki、Tomioka Yoshihisa、Ivanov Pavel
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 21 Pages: 13100-13100
- DOI
  10.3390/ijms232113100
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06865
[Journal Article] RNA biology of angiogenin: Current state and perspectives2017
- Author(s)
  Shawn M Lyons, Marta M Fay, Yasutoshi Akiyama, Paul J Anderson, and Pavel Ivanov
- Journal Title
  
  RNA Biology
  
  Volume: 14 Issue: 2 Pages: 171-178
- DOI
  10.1080/15476286.2016.1272746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860094
[Journal Article] Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage.2016
- Author(s)
  Suzuki T, Kanno SI, Abe T. et al
- Journal Title
  
  J Am Soc Nephrol.
  
  Volume: 27 Issue: 7 Pages: 1-8
- DOI
  10.1681/asn.2015060623
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26340020, KAKENHI-PROJECT-26460331, KAKENHI-PROJECT-26860094, KAKENHI-PROJECT-15H06367, KAKENHI-PROJECT-16H04678, KAKENHI-PROJECT-16H04710, KAKENHI-PROJECT-26282153, KAKENHI-PROJECT-15K17882, KAKENHI-PROJECT-16K12925, KAKENHI-PROJECT-16K14719, KAKENHI-PROJECT-16H02420, KAKENHI-PROJECT-26293031, KAKENHI-PROJECT-26305007
[Journal Article] Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases.2015
- Author(s)
  T Suzuki, H Yamaguchi, M Kikusato, （他11名）, Y Akiyama, Y Takeuchi, A Yuri, K Kikuchi, T Toyohara, C Suzuki, M Kohzuki, J Anzai, N Mano, S Kure, T Yanagisawa, Y Tomioka, M Toyomizu, S Ito, H Osaka, K Hayashi, and T Abe
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 236 Pages: 225-232
- NAID
  130005083526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860094
[Journal Article] Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD2014
- Author(s)
  Eikan Mishima, Shinji Fukuda, Hisato Shima, Akiyoshi Hirayama, Yasutoshi Akiyama, Yoichi Takeuchi, Noriko N Fukuda, Takehiro Suzuki, Chitose Suzuki, Akinori Yuri, Koichi Kikuchi, Yoshihisa Tomioka, Sadayoshi Ito, Tomoyoshi Soga, and Takaaki Abe
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 26 Issue: 8 Pages: 1-8
- DOI
  10.1681/asn.2014060530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860094, KAKENHI-PROJECT-26860624, KAKENHI-PROJECT-26293031, KAKENHI-PROJECT-26305007
[Journal Article] 尿毒素の輸送とCKD2013
- Author(s)
  2.秋山泰利、阿部高明
- Journal Title
  
  腎と骨代謝
  
  Volume: 26 Pages: 223-229
- Data Source
  KAKENHI-PROJECT-24890013
[Journal Article] Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regul ation of GATA32013
- Author(s)
  Akiyama Y, Kikuchi K, Saigusa D, Suzuki T, Takeuchi Y, Mishima E, Yamamoto Y, Ishida A, Sugawara D, Jinno D, Shima H, Toyohara T, Suzuki C, Souma T, Moriguchi T, Tomioka Y, Ito S, Abe T.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 7 Pages: e66518-e66518
- DOI
  10.1371/journal.pone.0066518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07924, KAKENHI-PROJECT-23390033, KAKENHI-PROJECT-24590177, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24659062, KAKENHI-PROJECT-24890013, KAKENHI-PROJECT-25430135, KAKENHI-PROJECT-25860021
[Journal Article] Carrier-mediated transport of quercetin conjugates : Involvement of organic anion transporters and organic anion transporting polypeptides2012
- Author(s)
  Wong C, Akiyama Y, Abe T et al.
- Journal Title
  
  Biochem. Pharmacol
  
  Volume: 84 Issue: 4 Pages: 564-570
- DOI
  10.1016/j.bcp.2012.05.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890013
[Journal Article] A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS).2012
- Author(s)
  Akiyama Y.
- Journal Title
  
  Toxins
  
  Volume: 4 Issue: 11 Pages: 1309-1322
- DOI
  10.3390/toxins4111309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390033, KAKENHI-PROJECT-24390211, KAKENHI-PROJECT-24590177, KAKENHI-PROJECT-24659062, KAKENHI-PROJECT-24890013
[Presentation] Cytoplasmic processing of human transfer RNAs2022
- Author(s)
  秋山泰利、阿部高明、富岡佳久、Pavel Ivanov
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-21K06865
[Presentation] RTCB ligase complex regulates stress-induced tRNA cleavage2022
- Author(s)
  竹中慶香、秋山泰利、松本洋太郎、富岡佳久
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-21K06865
[Presentation] CE-MSによる透析患者に特異的な尿毒素の網羅的探索2015
- Author(s)
  秋山泰利
- Organizer
  日本透析医学会総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-26860094
[Presentation] Indole-3-acetate Inhibits Erythropoietin Receptor Expression and Erythropoietin Signaling in vitro2013
- Author(s)
  秋山　泰利
- Organizer
  アメリカ腎臓学会
- Place of Presentation
  アメリカ　アトランタ
- Data Source
  KAKENHI-PROJECT-24890013
[Presentation] A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS)2012
- Author(s)
  秋山泰利
- Place of Presentation
  アメリカ腎臓学会
- Data Source
  KAKENHI-PROJECT-24890013
[Presentation] Metabolomic approach for clarifying the effect of AST-120 in 5/6 nephrectomized rats by capillary electrophoresis mass spectrometry2012
- Author(s)
  秋山　泰利
- Organizer
  アメリカ腎臓学会
- Place of Presentation
  アメリカ　サンディエゴ
- Data Source
  KAKENHI-PROJECT-24890013
[Presentation] CE-MSによる透析患者に特異的な尿毒素の網羅的探索
- Author(s)
  秋山泰利
- Organizer
  日本透析医学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-06-26 – 2015-06-28
- Data Source
  KAKENHI-PROJECT-26860094

1. Tomioka Yoshihisa (00282062)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 塚本宏樹 (70423605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 松本洋太郎 (90420041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 豊原敬文 (60594182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KANNO Shinichirou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akiyama Yasutoshi 秋山 泰利

AKIYAMA Yasutoshi 秋山 泰利

Research Projects

Research Products

Co-Researchers

疾患iPS細胞とストレス応答機構から迫るミトコンドリア病の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of CD73 internalization mechanism by low-molecular-weight compounds and development of anti-cancer drugs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Profiling of modified nucleosides in mitochondrial tRNAs for diagnosis of mitochondrial diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for molecules that control the CD39-CD73-adenosine cascade and expand into drug discovery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Kidney transporter and gut microbiota as therapeutic targets for chronic kidney diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of SLCO4C1 transporter-mediated excretion of uremic toxins as a therapeutic strategy for Chronic Kidney DiseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 慢性腎不全の病態トピックス9トランスポーター, 腎不全治療レシピ, 査読なし2013

Author(s)

Publisher

Data Source

[Book] Annual Review腎臓2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] RNase L Produces tRNA-derived RNAs that Contribute to Translation Inhibition2025

Author(s)

Journal Title

Data Source

[Journal Article] tRNA‐derived RNAs: Biogenesis and roles in translational control2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD98 regulates the phosphorylation of HER2 and a bispecific anti‐HER2/CD98 antibody inhibits the growth signal of human breast cancer cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxidative Stress, Transfer RNA Metabolism, and Protein Synthesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual‐targeting therapy against HER3/MET in human colorectal cancers2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selective Cleavage at CCA Ends and Anticodon Loops of tRNAs by Stress-Induced RNases2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RTCB Complex Regulates Stress-Induced tRNA Cleavage2022

Akiyama Yasutoshi 秋山泰利

AKIYAMA Yasutoshi 秋山泰利