SAIJO KEN 西條憲

… Alternative Names

SAIJO Ken 西條憲

Less

Researcher Number	70636729
Other IDs
Affiliation (Current)	2025: 東北大学, 大学病院, 講師
Affiliation (based on the past Project Information) *help	2024: 東北大学, 大学病院, 講師 2013 – 2019: 東北大学, 大学病院, 助教 2014: 東北大学, 病院, 助教 2012: 東北大学, 大学病院, 助手
Review Section/Research Field	Principal Investigator Tumor therapeutics / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Clinical oncology
Keywords	Principal Investigator PI3K / HDAC / 創薬 / 分子標的薬 / EGFR / 薬物療法 / 頭頸部癌 / DNAメチル化 / 分標的治療薬 / lenvatinib … More / 阻害剤ライブラリー / レンバチニブ / 甲状腺未分化癌 / 軟部肉腫 / 悪性末梢神経鞘腫 / 非臨床試験 / PI3K阻害 / HDAC阻害 / がん分子標的治療薬剤 / PI3K阻害剤 / HDAC阻害剤 … More Except Principal Investigator HDAC / PI3K / がん / 創薬 / ＨＤＡＣ阻害薬 / PI3K阻害薬 / 分子標的治療薬 Less

DNAメチル化状態に基づいた頭頸部癌薬物療法のバイオマーカー開発Principal Investigator
- Principal Investigator
  
  西條憲
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
Development of a novel treatment for anaplastic thyroid carcinomaPrincipal Investigator
- Principal Investigator
  
  Saijo Ken
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tohoku University
Development of novel therapeutic agents for malignant peripheral nerve sheath tumorPrincipal Investigator
- Principal Investigator
  
  Saijo Ken
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tohoku University
Development of novel HDAC/PI3K dual inhibitorsPrincipal Investigator
- Principal Investigator
  
  SAIJO KEN
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tohoku University
A search and optimization of the novel cancer molecules target drugs with PI3K/HDAC dual inhibition
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Tohoku University

All 2020 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Patent

[Journal Article] Antitumor activity and pharmacologic characterization of the depsipeptide analog as a novel HDAC/PI3K dual inhibitor.2017
- Author(s)
  Saijo K, Imai H, Chikamatsu S, Narita K, Katoh T, Ishioka C.
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中 Issue: 7 Pages: 1469-1475
- DOI
  10.1111/cas.13255
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18436, KAKENHI-PROJECT-15K07865
[Journal Article] Biochemical, biological and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors.2015
- Author(s)
  2.Saijo, K.，Imamura, J.，Narita, K.，Oda, A.，Shimodaira, H.，Katoh, T.，Ishioka, C.
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Issue: 2 Pages: 208-215
- DOI
  10.1111/cas.12585
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300339, KAKENHI-PROJECT-24590017, KAKENHI-PROJECT-25830110, KAKENHI-PROJECT-26460034, KAKENHI-PROJECT-15K07865
[Journal Article] Predicting the structures of complexes between phosphoinositide 3-kinase (PI3K) and romidepsin-related compounds for the drug design of PI3K/histone deacetylase dual inhibitors using computational docking and the ligand-based drug design approach.2014
- Author(s)
  Oda A, Saijo K, Ishioka C, Narita K, Katoh T, Watanabe Y, Fukuyoshi S, Takahashi O.
- Journal Title
  
  Journal of Molecular Graphics and Modelling
  
  Volume: 54 Pages: 46-53
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25830110
[Journal Article] Predicting the structures of complexes between phosphoinositide 3-kinase (PI3K) and romidepsin-related compounds for the drug design of PI3K/histone deacetylase dual inhibitors using computational docking and the ligand-based drug design approach.2014
- Author(s)
  Oda, A.，Saijo, K.，Ishioka, C.，Narita, K.，Katoh, T.，Watanabe, Y.，Fukuyoshi, S.，Takahashi, O.
- Journal Title
  
  J Mol Graph Model
  
  Volume: 54 Pages: 46-53
- DOI
  10.1016/j.jmgm.2014.08.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300339, KAKENHI-PROJECT-24590017, KAKENHI-PROJECT-26460034
[Journal Article] Romidepsin (FK228) and its analogs directly inhibit PI3K activity and potently induce apoptosis as HDAC/PI3K dual inhibitors2012
- Author(s)
  Ken Saijo, Tadashi Katoh, Hideki Shimodaira, Akifumi Oda, Ohgi Takahashi, Chikashi Ishioka
- Journal Title
  
  Cancer Science
  
  Volume: 103 Issue: 11 Pages: 1994-2001
- DOI
  10.1111/cas.12002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790137, KAKENHI-PROJECT-24300339, KAKENHI-PROJECT-24590017
[Patent] Novel phosphatidylinositol-3-kinase inhibitor and pharmaceutical composition2014
- Inventor(s)
  西條憲、石岡千加史、加藤正
- Industrial Property Rights Holder
  東北大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-05-27
- Overseas
- Data Source
  KAKENHI-PROJECT-24300339
[Patent] 新規ホスファチジルイノシトール3キナーゼ阻害剤及び医薬組成物2012
- Inventor(s)
  西條憲, 石岡千加史, 加藤正
- Industrial Property Rights Holder
  東北大学
- Filing Date
  2012-09-25
- Overseas
- Data Source
  KAKENHI-PROJECT-24300339
[Presentation] 甲状腺未分化癌細胞におけるlenvatinibとIRAK1/4 inhibitor Iの併用効果の検討2020
- Author(s)
  川村佳史、西條憲、今井源、石岡千加史
- Organizer
  日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07211
[Presentation] Evaluation of anti-tumor effects of depsipeptide analogs as HDAC/PI3K dual inhibitors in human soft tissue sarcoma cells2016
- Author(s)
  Ken SAIJO, Koichi NARITA, Tadashi KATOH, and Chikashi ISHIOKA
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18436
[Presentation] Characterization of depsipeptide analogs as PI3K inhibitors2015
- Author(s)
  Ken SAIJO, Koichi NARITA, Tadashi KATOH, and Chikashi ISHIOKA
- Organizer
  日本癌学会学術総会
- Place of Presentation
  名古屋, 名古屋国際会議場
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15K18436
[Presentation] In vivo anti-tumor activity of FK-A11, a depsipeptide analog targeting both histone deacetylase and phosphoinositide 3-kinase2015
- Author(s)
  Ken Saijo, Koichi Narita, Tadashi Katoh, and Chikashi Ishioka
- Organizer
  ESMO Asia
- Place of Presentation
  singapore, Singapore
- Year and Date
  2015-12-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18436
[Presentation] In vitroおよびin vivoにおけるPI3K/HDAC 2重阻害剤としてのFK228類縁体の抗腫瘍効果の評価2014
- Author(s)
  李　仁、西條　憲、下平　秀樹、成田　紘一、加藤　正、石岡　千加史
- Organizer
  日本がん分子標的学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-25830110
[Presentation] In vivo antitumor activity of Romidepsin analogs as novel HDAC/PI3K dual inhibitors.2014
- Author(s)
  Ken SAIJO, Jin LEE, Koichi NARITA, Tadashi KATOH, Hideki SHIMODAIRA, and Chikashi ISHIOKA
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-25830110
[Presentation] 新規HDAC/PI3K 2重阻害剤としてのデプシペプチド類縁体の抗腫瘍活性の検討2014
- Author(s)
  西條憲，李仁，成田紘一，加藤正，下平秀樹，石岡千加史
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-24300339
[Presentation] In vitroおよびin vivoにおけるPI3K/HDAC 2重阻害剤としてのFK228類縁体の抗腫瘍効果の評価2014
- Author(s)
  李仁，西條憲，下平秀樹，成田紘一，加藤正，石岡千加史
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-24300339
[Presentation] 457. HDAC/PI3K dual inhibitorとしてのRomidepsin(FK228)新規類縁体の開発と最適化2013
- Author(s)
  李仁, 西條憲, 下平秀樹, 成田紘一, 加藤正, 石岡千加史
- Organizer
  第17回日本がん分子標的治療学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24300339
[Presentation] Romidepsin(FK228) and its analogs exhibit potent cytotoxicity through HDAC/PI3K dual inhibition in colorectal cancer cell lines.2013
- Author(s)
  Saijo K, et al.
- Organizer
  AACR/JCA Joint Conference
- Place of Presentation
  Maui, Hawai, USA
- Year and Date
  2013-02-24
- Data Source
  KAKENHI-PROJECT-24300339
[Presentation] 新規HDAC/PI3K 2重阻害剤としてのロミデプシン類縁体の同定2012
- Author(s)
  西條憲, ほか
- Organizer
  第16回がん分子標的治療学会学術集会
- Place of Presentation
  北九州市
- Year and Date
  2012-06-27
- Data Source
  KAKENHI-PROJECT-24300339
[Presentation] HDAC/PI3K dual inhibitorとしてのFK228類縁体の同定と開発
- Author(s)
  西條憲、李仁、加藤正、小田章史、下平秀樹、石岡千加史
- Organizer
  部科学省　新学術領域研究　がん研究分野の特性等を踏まえた支援活動
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25830110

1. ISHIOKA Chikashi (60241577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. KATO Tadashi (50382669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 大内康太 (50781291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. LI Jin

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. ODA Akifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAIJO KEN 西條 憲

SAIJO Ken 西條 憲

Research Projects

Research Products

Co-Researchers

DNAメチル化状態に基づいた頭頸部癌薬物療法のバイオマーカー開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel treatment for anaplastic thyroid carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic agents for malignant peripheral nerve sheath tumorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel HDAC/PI3K dual inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A search and optimization of the novel cancer molecules target drugs with PI3K/HDAC dual inhibition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Antitumor activity and pharmacologic characterization of the depsipeptide analog as a novel HDAC/PI3K dual inhibitor.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical, biological and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predicting the structures of complexes between phosphoinositide 3-kinase (PI3K) and romidepsin-related compounds for the drug design of PI3K/histone deacetylase dual inhibitors using computational docking and the ligand-based drug design approach.2014

Author(s)

Journal Title

Data Source

[Journal Article] Predicting the structures of complexes between phosphoinositide 3-kinase (PI3K) and romidepsin-related compounds for the drug design of PI3K/histone deacetylase dual inhibitors using computational docking and the ligand-based drug design approach.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Romidepsin (FK228) and its analogs directly inhibit PI3K activity and potently induce apoptosis as HDAC/PI3K dual inhibitors2012

Author(s)

Journal Title

DOI

Data Source

[Patent] Novel phosphatidylinositol-3-kinase inhibitor and pharmaceutical composition2014

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 新規ホスファチジルイノシトール3キナーゼ阻害剤及び医薬組成物2012

Inventor(s)

Industrial Property Rights Holder

Filing Date

Data Source

[Presentation] 甲状腺未分化癌細胞におけるlenvatinibとIRAK1/4 inhibitor Iの併用効果の検討2020

Author(s)

Organizer

Data Source

[Presentation] Evaluation of anti-tumor effects of depsipeptide analogs as HDAC/PI3K dual inhibitors in human soft tissue sarcoma cells2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

SAIJO KEN 西條憲

SAIJO Ken 西條憲