Kagoya Yuki 籠谷勇紀

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KAGOYA YUKI 籠谷勇紀

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Researcher Number	70706960
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 教授 2025: 愛知県がんセンター(研究所), 腫瘍免疫応答研究分野, 客員研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 慶應義塾大学, 医学部(信濃町), 教授 2022: 愛知県がんセンター(研究所), 腫瘍免疫応答研究分野, 客員研究員 2019 – 2021: 愛知県がんセンター(研究所), 腫瘍免疫応答研究分野, 分野長 2013 – 2014: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Hematology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator キメラ抗原受容体 / メモリーT細胞 / T細胞疲弊 / 養子免疫療法 / エピジェネティクス / 悪性腫瘍 / エピジェネティック因子 / エフェクターT細胞 / 遺伝子改変 / NK細胞 … More / メモリー形成 / ＮＫ細胞 / 自然免疫 / 免疫監視・腫瘍免疫 / 細胞免疫療法 / 薬剤送達 / 抗体薬物複合体 / 抗体医薬品 / 疲弊 / T細胞 / 免疫チェックポイント阻害剤 / 抗体医薬 / 免疫細胞療法 / CRISPR/Cas9 / 転写因子 / T細胞性リンパ腫 / 遺伝子変異 / 抗腫瘍T細胞 / 転写制御因子 / JAK-STAT経路 / PD-1 / 長期生存能 / 免疫チェックポイント分子 / サイトカイン / 鉄過剰 / JAK2V617F / ｐ５３ / JAK2V617F変異 / 活性酸素 / p53 / DNA損傷 / リポカリン-2 / JAK2V617F遺伝子変異 / 急性骨髄性白血病 / 骨髄増殖性腫瘍 … More Except Principal Investigator がんワクチン / 術後再発予防 / T細胞 / 腫瘍抗原 / 肺癌 Less

Balancing memory and effector T cell function through epigenetic modificationPrincipal Investigator
- Principal Investigator
  
  籠谷勇紀
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Keio University
Development of a long-surviving CAR-NK cells through genetic modificationPrincipal Investigator
- Principal Investigator
  
  籠谷勇紀
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
The determination of T-cell fate by different tumor antigens and prevention of post-operative recurrence of lung cancer
- Principal Investigator
  
  松下博和
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Aichi Cancer Center Research Institute
Development of a combinatorial approach of antibody therapeutics and adoptive immunotherapy for cancerPrincipal Investigator
- Principal Investigator
  
  Kagoya Yuki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Aichi Cancer Center Research Institute
Generation of long-surviving antitumor T cells by genetic modification for optimal adoptive immunotherapyPrincipal Investigator
- Principal Investigator
  
  Kagoya Yuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Aichi Cancer Center Research Institute
Development of a chimeric synthetic receptor to suppress T cell exhaustion for use in adoptive cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  Kagoya Yuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Aichi Cancer Center Research Institute
Elucidation of the mechanism of transformation of myeloproliferative neoplasm into acute myelogenous leukemia for novel therapeutic strategy for the disease.Principal Investigator
- Principal Investigator
  
  KAGOYA YUKI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2014 2013 Other

All Journal Article Presentation Other

[Journal Article] Gene editing technology to improve antitumor T-cell functions in adoptive immunotherapy2024
- Author(s)
  Ito Y, Inoue S, Kagoya Y.
- Journal Title
  
  Inflamm Regen .
  
  Volume: 44 Issue: 1 Pages: 13-13
- DOI
  10.1186/s41232-024-00324-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19474, KAKENHI-PROJECT-23K24171, KAKENHI-PROJECT-23K27470
[Journal Article] CD83 expression characterizes precursor exhausted T cell population2023
- Author(s)
  Wu Zhiwen、Yoshikawa Toshiaki、Inoue Satoshi、Ito Yusuke、Kasuya Hitomi、Nakashima Takahiro、Zhang Haosong、Kotaka Saki、Hosoda Waki、Suzuki Shiro、Kagoya Yuki
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 258-258
- DOI
  10.1038/s42003-023-04631-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03543, KAKENHI-PROJECT-23K24171, KAKENHI-PROJECT-23K14554, KAKENHI-PROJECT-22K19474
[Journal Article] Epigenetic profiles guide improved CRISPR/Cas9-mediated gene knockout in human T cells2023
- Author(s)
  Ito Yusuke、Inoue Satoshi、Nakashima Takahiro、Zhang Haosong、Li Yang、Kasuya Hitomi、Matsukawa Tetsuya、Wu Zhiwen、Yoshikawa Toshiaki、Kataoka Mirei、Ishikawa Tetsuo、Kagoya Yuki
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 52 Issue: 1 Pages: 141-153
- DOI
  10.1093/nar/gkad1076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21837, KAKENHI-PROJECT-21K02356, KAKENHI-PROJECT-22K19474, KAKENHI-PROJECT-23K24171, KAKENHI-PROJECT-23K27470
[Journal Article] Cytokine signaling in chimeric antigen receptor T-cell therapy2023
- Author(s)
  Kagoya Yuki
- Journal Title
  
  International Immunology
  
  Volume: 36 Issue: 2 Pages: 49-56
- DOI
  10.1093/intimm/dxad033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27470
[Journal Article] Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy2020
- Author(s)
  Kagoya Yuki、Guo Tingxi、Yeung Brian、Saso Kayoko、Anczurowski Mark、Wang Chung-Hsi、Murata Kenji、Sugata Kenji、Saijo Hiroshi、Matsunaga Yukiko、Ohashi Yota、Butler Marcus O.、Hirano Naoto
- Journal Title
  
  Cancer Immunology Research
  
  Volume: 8 Issue: 7 Pages: 926-936
- DOI
  10.1158/2326-6066.cir-18-0508
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03543, KAKENHI-PROJECT-19K22552
[Journal Article] JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2.2014
- Author(s)
  Kagoya Y, Yoshimi A, Tsuruta-Kishino T, Arai S, Satoh T, Akira S, Kurokawa M.
- Journal Title
  
  Blood
  
  Volume: 124 Issue: 19 Pages: 2996-3006
- DOI
  10.1182/blood-2014-04-570572
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249055, KAKENHI-PROJECT-25893047, KAKENHI-PROJECT-26860474
[Presentation] 次世代型 CAR-T 細胞療法の技術開発2023
- Author(s)
  籠谷　勇紀
- Organizer
  第36回日本バイオセラピィ学会学術集会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27470
[Presentation] 第46回日本造血・免疫細胞療法学会総会2023
- Author(s)
  籠谷　勇紀
- Organizer
  第46回日本造血・免疫細胞療法学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27470
[Presentation] Understanding the mechanisms of resistance to CAR-T cell therapy at the molecular level2023
- Author(s)
  Yuki Kagoya
- Organizer
  第1回日本がん免疫学会国際がん免疫シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27470
[Presentation] Genetic modification of antitumor T cells for optimal adoptive cancer immunotherapy2022
- Author(s)
  Yuki Kagoya
- Organizer
  Franco-Japanese immuno-oncology webinars series
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] エピジェネティクス改変による長期生存型CAR-T細胞の製造2022
- Author(s)
  籠谷勇紀
- Organizer
  第14回日本血液疾患免疫療法学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] エピジェネティック機構の制御による抗腫瘍T細胞の改変2022
- Author(s)
  籠谷勇紀
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19422
[Presentation] CAR-T 細胞療法の適用拡大に向けた研究開発2022
- Author(s)
  籠谷勇紀
- Organizer
  第7回日本がんサポーティブケア学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] エピジェネティクス改変による長期生存型CAR-T細胞の製造2022
- Author(s)
  籠谷勇紀
- Organizer
  第14回日本血液疾患免疫療法学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19422
[Presentation] Synthetic immunology to enhance safety and efficacy in adoptive cancer immunotherapy2022
- Author(s)
  籠谷勇紀
- Organizer
  第51回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Genetic modification of antitumor T cells for optimal adoptive cancer immunotherapy2022
- Author(s)
  Yuki Kagoya
- Organizer
  Franco-Japanese immuno-oncology webinars series
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19422
[Presentation] 次世代型CAR-T細胞療法の開発2022
- Author(s)
  籠谷勇紀
- Organizer
  第6回バイオ医薬EXPO
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Synthetic immunology to enhance safety and efficacy in adoptive cancer immunotherapy2022
- Author(s)
  籠谷勇紀
- Organizer
  第51回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19422
[Presentation] エピジェネティック機構の制御による抗腫瘍T細胞の改変2022
- Author(s)
  籠谷勇紀
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] エピジェネティクス修飾によるCAR-T細胞の改良2022
- Author(s)
  籠谷勇紀
- Organizer
  第3回東京理科大学総合研究院合成生物学研究部門シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] 転写ネットワーク修飾による T細胞機能の改変2021
- Author(s)
  籠谷勇紀
- Organizer
  第94回日本生化学大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Epigenetic modification of antitumor T cells to induce durable clinical response in adoptive immunotherapy2021
- Author(s)
  吉川聡明, 呉智聞, 松下博和, 細田和貴, 鈴木史朗, 籠谷勇紀
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] 転写ネットワーク修飾による T細胞機能の改変2021
- Author(s)
  籠谷　勇紀
- Organizer
  第94回日本生化学大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19422
[Presentation] 次世代CART細胞療法の開発動向2021
- Author(s)
  籠谷勇紀
- Organizer
  BioJapan 2021
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Epigenetic and metabolic modification of CAR-T cells for optimal adoptive immunotherapy2021
- Author(s)
  Yuki Kagoya
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Redefining T cell exhaustion - Understanding T cell states at molecular levels2021
- Author(s)
  籠谷　勇紀
- Organizer
  第50回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19422
[Presentation] Memory Response of Gene Therapy Product; in View of Biodistribution2021
- Author(s)
  Yuki Kagoya
- Organizer
  6th DIA Cell and Gene Therapy Products Symposium in Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Future perspectives of CAR-T cell therapy for cancer2021
- Author(s)
  Yuki Kagoya
- Organizer
  The 25th JFCR-ISCC
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Epigenetic regulation of antitumor T cell functions2021
- Author(s)
  籠谷　勇紀
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19422
[Presentation] 抗腫瘍T細胞の機能評価を行う上でのポイント2021
- Author(s)
  籠谷勇紀
- Organizer
  日本再生医療学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Epigenetic insights into T cell longevity for optimal adoptive immunotherapy2021
- Author(s)
  Yuki Kagoya
- Organizer
  JCA-AACR Precision Cancer Medicine International Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] 抗腫瘍T細胞の機能評価を行う上でのポイント2021
- Author(s)
  籠谷　勇紀
- Organizer
  日本再生医療学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22552
[Presentation] Redefining T cell exhaustion - Understanding T cell states at molecular levels2021
- Author(s)
  籠谷勇紀
- Organizer
  第50回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Epigenetic modification of antitumor T cells for optimal adoptive immunotherapy2021
- Author(s)
  吉川聡明, 呉智聞, 松下博和,細田和貴, 鈴木史朗, 籠谷勇紀
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Epigenetic modification of CAR-T cells for optimal adoptive immunotherapy,2020
- Author(s)
  籠谷勇紀
- Organizer
  第79回日本癌学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] Epigenetic modification of CAR-T cells for optimal adoptive immunotherapy2020
- Author(s)
  籠谷　勇紀
- Organizer
  第79回日本癌学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22552
[Presentation] 免疫工学によるCAR-T細胞の改良開発2020
- Author(s)
  籠谷勇紀
- Organizer
  血液疾患免疫療法学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] 免疫工学によるCAR-T細胞の改良開発2020
- Author(s)
  籠谷　勇紀
- Organizer
  血液疾患免疫療法学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22552
[Presentation] 合成生物学による免疫細胞療法の改良2020
- Author(s)
  籠谷勇紀
- Organizer
  日本輸血・細胞治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03543
[Presentation] 合成生物学による免疫細胞療法の改良2020
- Author(s)
  籠谷　勇紀
- Organizer
  日本輸血・細胞治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22552
[Presentation] Genetic manipulation of antitumor T cells to elicit durable clinical response in adoptive immunotherapy2019
- Author(s)
  Yuki Kagoya
- Organizer
  SITC 2019 World Immunotherapy Council’s 3rd Young Investigator Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22552
[Presentation] JAK2V617F mutation evokes paracrine DNA damage to adjacent cells and drives leukemic transformation.2013
- Author(s)
  籠谷勇紀、吉見昭秀、鶴田貴子、片岡圭亮、荒井俊也、黒川峰夫
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25893047
[Presentation] JAK2V617F mutation evokes paracrine DNA damage to adjacent normal cells via secretion of lipocalin-22013
- Author(s)
  Yuki Kagoya, Shunya Arai, Akihide Yoshimi, Takako Tsuruta-Kishino1, Keisuke Kataoka, Mineo Kurokawa
- Organizer
  55th ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-25893047
[Presentation] JAK2V617F mutation evokes paracrine DNA damage to adjacent cells and drives leukemic transformation.2013
- Author(s)
  籠谷勇紀、吉見昭秀、鶴田貴子、片岡圭亮、荒井俊也、黒川峰夫
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25893047
[]

1. 松下博和 (80597782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 黒田浩章 (20365274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 真砂勝泰 (80338160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山口類 (90380675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 石川哲朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 黒川峰夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 井上聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kagoya Yuki 籠谷 勇紀

KAGOYA YUKI 籠谷 勇紀

Research Projects

Research Products

Co-Researchers

Balancing memory and effector T cell function through epigenetic modificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a long-surviving CAR-NK cells through genetic modificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The determination of T-cell fate by different tumor antigens and prevention of post-operative recurrence of lung cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a combinatorial approach of antibody therapeutics and adoptive immunotherapy for cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of long-surviving antitumor T cells by genetic modification for optimal adoptive immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a chimeric synthetic receptor to suppress T cell exhaustion for use in adoptive cancer immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of transformation of myeloproliferative neoplasm into acute myelogenous leukemia for novel therapeutic strategy for the disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Gene editing technology to improve antitumor T-cell functions in adoptive immunotherapy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD83 expression characterizes precursor exhausted T cell population2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic profiles guide improved CRISPR/Cas9-mediated gene knockout in human T cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytokine signaling in chimeric antigen receptor T-cell therapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] 次世代型 CAR-T 細胞療法の技術開発2023

Author(s)

Organizer

Kagoya Yuki 籠谷勇紀

KAGOYA YUKI 籠谷勇紀

[Presentation] CAR-T 細胞療法の適用拡大に向けた研究開発2022