TAKANARI HIROKI 高成広起

… Alternative Names

Researcher Number	70723253
Other IDs
Affiliation (Current)	2019: 徳島大学, ポストLEDフォトニクス研究所, 特任講師
Affiliation (based on the past Project Information) *help	2019: 徳島大学, ポストLEDフォトニクス研究所, 特任講師 2016 – 2019: 徳島大学, 病院, 特任講師 2014 – 2015: 大分大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Medical Physics and Radiological Technology / Basic Section 90110:Biomedical engineering-related Except Principal Investigator Experimental pathology / Nerve anatomy/Neuropathology / Legal medicine / Pediatrics / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator ラマン散乱光分析 / 心筋ギャップ結合 / Connexin43 / Connexin40 / カルモデュリン / CaMK-II / 脂質負荷 / コネキシン43 / コネキシン40 / カルモデュリン関連タンパクキナーゼ … More Except Principal Investigator 心筋再生 / 細胞質分裂 / 二核化 / プロテオミクス / 細胞周期 / 細胞分裂 / コケイン症候群 / 心嚢破裂 / 生体シミュレーション / 応力 / 心タンポナーデ / コンピューターシミュレーション / 循環器 / シミュレーション工学 / 社会医学 / ダウン症候群 / トリソミー / 染色体工学 / ゲノム編集 / iPS細胞 / CRISPR/Cas / 染色体 / 再生医学 / 遺伝学 / トリソミックレスキュー / アルコール脱水素酵素 Less

Alcohol dehydrogenase in alcohol-related organ disorderOngoing
- Principal Investigator
  
  奥田貴久
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nippon Medical School
Development of magnetic resonance Raman spectrometry for application of optical technology to living bodyPrincipal InvestigatorOngoing
- Principal Investigator
  
  高成広起
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  The University of Tokushima
A new technology for tissue diagnosis with combination of Raman scattering spectrometry and bioimpedance measurementPrincipal Investigator
- Principal Investigator
  
  高成広起
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical Physics and Radiological Technology
- Research Institution
  The University of Tokushima
心肺蘇生時の胸部圧迫に伴う心嚢破裂発生機序の解明Ongoing
- Principal Investigator
  
  奥田貴久
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Nippon Medical School
Proof of concept study of a novel excess chromosome elimination therapy to ameliorate and prevent trisomy 21 associated complications
- Principal Investigator
  
  橋詰令太郎
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
Abnormal transcriptional regulation in Cockayne syndrome and its effect on neuronal differentiation
- Principal Investigator
  
  HASHIMOTO Satoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokushima
  Oita University
Myocardial regeneration research based on cell-cycle progression of the adult myocyte
- Principal Investigator
  
  Hashizume Ryotaro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Mie University
Effects of fetal gene reprogramming on expression, distribution and expression of gap junction in failing heartsPrincipal Investigator
- Principal Investigator
  
  Takanari Hiroki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Oita University

All 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors2019
- Author(s)
  Umeda Ryohei、Takanari Hiroki、Ogata Kazue、Matsumoto Shigekiyo、Kitano Takaaki、Ono Katsushige、Tokumaru Osamu
- Journal Title
  
  J. Clin. Biochem. Nutr.
  
  Volume: 64 Issue: 1 Pages: 20-26
- DOI
  10.3164/jcbn.18-48
- NAID
  130007542260
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11087, KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-15K10515, KAKENHI-PROJECT-16K09964
[Journal Article] Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa , are I Kr blockers with proarrhythmic effects in vitro and in vivo2018
- Author(s)
  Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P, Linder T, Stary-Weinzinger A, van der Heyden MAG, Houtman M, Takanari H, Jonsson M, Beekman JHD, Hamburger M, Vos MA, Hering S.
- Journal Title
  
  Pharmacological Research
  
  Volume: 131 Pages: 150-163
- DOI
  10.1016/j.phrs.2018.02.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-16K09964
[Journal Article] Interleukin 10 Treatment Ameliorates High-Fat Diet?Induced Inflammatory Atrial Remodeling and Fibrillation2018
- Author(s)
  Kondo H, Abe I, Gotoh K, Fukui A, Takanari H, Ishii Y, Ikebe Y, Kira S, Oniki T, Saito S, Aoki K, Tanino T, Mitarai K, Kawano K, Miyoshi M, Fujinami M, Yoshimura S, Ayabe R, Okada N, Nagano Y, Akioka H, Shinohara T, Akiyoshi K, Masaki T, Teshima Y, Yufu K, Nakagawa M, Takahashi N.
- Journal Title
  
  Circulation: Arrhythmia and Electrophysiology
  
  Volume: 11
- DOI
  10.1161/circep.117.006040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-16K09964
[Journal Article] Testosterone-mediated upregulation of delayed rectifier potassium channel in cardiomyocytes causes abbreviation of QT intervals in rats2018
- Author(s)
  Masuda K, Takanari H, Morishima M, Ma F, Wang Y, Takahashi N, Ono K.
- Journal Title
  
  J Physiol Sci.
  
  Volume: Jan 13 Pages: 759-767
- DOI
  10.1007/s12576-017-0590-4
- NAID
  40021720520
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08498, KAKENHI-PROJECT-15KK0313, KAKENHI-PROJECT-15K08179, KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-16K09964
[Journal Article] Response to the letter from Warren et al.2017
- Author(s)
  Takanari H, Fontes MSC, van der Heyden MAG, Vos MA, van Veen TAB.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 113 Pages: 1799-1800
- DOI
  10.1093/cvr/cvx200
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05238
[Journal Article] PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression.2017
- Author(s)
  Ji Y, Veldhuis MG, Zandvoort J, Romunde FL, Houtman MJC, Duran K, van Haaften G, Zangerl-Plessl EM, Takanari H, Stary-Weinzinger A, van der Heyden MAG.
- Journal Title
  
  J Biomed Sci
  
  Volume: 24 Pages: 44-44
- DOI
  10.1186/s12929-017-0352-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05238
[Journal Article] Class III antiarrhythmic drugs amiodarone and dronedarone impair KIR2.1 backward trafficking2017
- Author(s)
  Ji Y, Takanari H, Nalos L, Houtman MJC, Heukers R, van Bergen en Henegouwen PMP, Vos MA, van der Heyden MAG.
- Journal Title
  
  Journal of Cellular and Molecular Medicine
  
  Volume: 印刷中
- DOI
  10.1111/jcmm.13172
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05238
[Journal Article] Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K+ Channel, IK.ACh2017
- Author(s)
 Morishima M, Iwata E, Nakada C, Tsukamoto Y, Takanari H, Miyamoto S, Moriyama M, Ono K
- Journal Title
 
 Circulation Journal
 
 Volume: 80 Issue: 6 Pages: 1346-1355
- DOI
 10.1253/circj.CJ-15-1276
- NAID
 130005153582
- ISSN
 1346-9843, 1347-4820
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
 KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-15K08179, KAKENHI-PROJECT-15K08405, KAKENHI-PROJECT-16K08498
[Journal Article] Calmodulin/CaMKII inhibition improves intercellular communication and impuslse propagation in the heart, and is anti-arrhythmic under conditions when fibrosis is absent2016
- Author(s)
  Takanari H, Bourqonje VJ, Fontes MS, Raaijmakers AJ, Driessen H, Jansen JA, van der Nagel R, Kok B, van Stuijvenberg L, Boulaksil M, Takemoto Y, Yamazaki M, Tsuji Y, Honjo H, Kamiya K. Kodama I, Anderson ME, van der Heyden MA, van Rijen HV, van Veen TA, Vos MA
- Journal Title
  
  Cardiovascular Research
  
  Volume: 111 Pages: 410-421
- DOI
  10.1093/cvr/cvw173
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01801, KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-15K09078
[Journal Article] Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil.2016
- Author(s)
  Ma F, Takanari H, Masuda K, Morishima M, Ono K.
- Journal Title
  
  Heart and Vessels
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860215
[Journal Article] ジギタリスー伝統的薬剤を現代医療でどのように用いるか2016
- Author(s)
  高成広起
- Journal Title
  
  循環器内科
  
  Volume: 80 Pages: 3-9
- Data Source
  KAKENHI-PROJECT-16H05238
[Journal Article] Partial IK1 blockade destabilizes spiral wave rotation center without inducing wave breakup and facilitates termination of reentrant arrhythmias in ventricles2016
- Author(s)
  Kushiyama Y, Honjo H, Niwa R, Takanari H, Yamazaki M, Takemoto Y, Sakuma I, Kodama I, Kamiya K
- Journal Title
  
  American Journal of Physiology - Heart and Circulatory Physiology
  
  Volume: 311
- DOI
  10.1152/ajpheart.00228.2016
- NAID
  120005946586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05238
[Journal Article] A New In Vitro Co-Culture Model Using Magnetic Force-Based Nanotechnology2016
- Author(s)
  Takanari H, Miwa K, Fu X, Nakai J, Ito A, Ino K, Honda H, Tonomura W, Konishi S, Opthof T, van der Heyden MA, Kodama I, Lee JK.
- Journal Title
  
  Journal of cellular physiology
  
  Volume: 未定 Pages: 2249-2256
- DOI
  10.1002/jcp.25342
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860215, KAKENHI-PROJECT-26293188, KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-15H05723
[Journal Article] Atrial fibrillation-mediated up-regulation of miR-30d regulates myocardial electrical remodeling of G-protein-gated K+ channel, IK,ACh.2016
- Author(s)
  Morishima M, Iwata E, Nakada C, Tsukamoto Y, Takanari H, Minamoto S, Moriyama M, Ono K.
- Journal Title
  
  Circulation Journal
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860215
[Journal Article] ATP感受性K+チャネル病の新規症候群ーCantu症候群2016
- Author(s)
  平木洋子、高成広起
- Journal Title
  
  脳と発達
  
  Volume: 48 Pages: 325-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05238
[Journal Article] Pericardial tear as a consequence of cardiopulmonary resuscitation (CPR) involving chest compression: a report of two postmortem cases of acute type A aortic dissection with hemopericardium.2015
- Author(s)
  Okuda T, Takanari H, Shiotani S, Hayakawa H, Ohno Y, Fowler DR.
- Journal Title
  
  Legal Medicine (Tokyo)
  
  Volume: 17 Pages: 201-204
- DOI
  10.1016/j.legalmed.2014.12.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860215
[Journal Article] ATP感受性K+チャネル病の新規症候群ーCantu症候群2015
- Author(s)
  平木洋子、高成広起
- Journal Title
  
  脳と発達
  
  Volume: 97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860215
[Journal Article] A systematic review and pooled analysis of CPR-associated cardiovascular and thoracic injuries.2015
- Author(s)
  Okuda T, Takanari H, Shiotani S,
- Journal Title
  
  Resuscitation
  
  Volume: 97
- DOI
  10.1016/j.resuscitation.2014.12.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860215
[Presentation] The influence of KATP channel abnormality on calcium handling of endoplasmic reticulum.2019
- Author(s)
  Takanari H
- Organizer
  The 9th. Federation of the Asian and Oceanian Physiological Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05238
[Presentation] 皮膚の炎症を定量評価する光技術を用いた計測機器開発2018
- Author(s)
  高成広起
- Organizer
  第6回TR推進合同フォーラム（九州大学ARO主催）
- Data Source
  KAKENHI-PROJECT-16H05238
[Presentation] ラマン散乱光分析を用いた皮膚悪性黒色腫の非侵襲的組織診断機器の開発2016
- Author(s)
  井上高教、橋本悟、高成広起
- Organizer
  第4回　TR推進合同フォーラム　ライフサイエンス技術交流会
- Place of Presentation
  九州大学医学部百年講堂（福岡市、福岡県）
- Data Source
  KAKENHI-PROJECT-16H05238
[Presentation] 不整脈基質におけるギャップ結合と線維化2016
- Author(s)
  高成広起
- Organizer
  第1回　START研究会
- Place of Presentation
  札幌コンベンションセンター（札幌市、北海道）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05238
[Presentation] Structure-based analysis of the function of Kir2.1 channel using a novel IK1 blocker PA-6: Interplay of PA-6, intracellular spermine2016
- Author(s)
  Hiroki Takanari
- Organizer
  第93回日本生理学会大会シンポジウム
- Place of Presentation
  札幌コンベンションセンター、北海道、札幌市
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-26860215
[Presentation] 心筋Gap junctionのリモデリングと興奮伝導時間・Spiral-reentry・不整脈との関連2015
- Author(s)
  高成広起
- Organizer
  第10回 EP Expertsカンファレンス教育講演
- Place of Presentation
  TKP天神シティセンター、福岡県、福岡市
- Year and Date
  2015-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-26860215
[Presentation] 炎症と脂質負荷が心房細動発症に及ぼす影響2014
- Author(s)
  高成広起
- Organizer
  第24回日本循環薬理学会
- Place of Presentation
  山形テルサ（山形県山形市）
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-26860215
[Presentation] カルモデュリン関連蛋白キナーゼ阻害が心筋興奮伝播に及ぼす影響：Connexin43発現分布の制御を介した作用2014
- Author(s)
  高成広起
- Organizer
  第13回九州脳・高血圧・循環制御研究会
- Place of Presentation
  ホテル日航福岡（福岡県福岡市）
- Year and Date
  2014-07-19
- Data Source
  KAKENHI-PROJECT-26860215

1. Hashizume Ryotaro (50456662)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. HASHIMOTO Satoru (60352150)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 井上高教 (40243969)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 奥田貴久 (20620305)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Shimojo Naoshi (70410751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Kuroda Taruho (00391946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Hara Mari (30176383)

# of Collaborated Projects: 1 results

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8. 芦原貴司 (80396259)

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9. 花田克浩 (90581009)

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10. 寺林健 (40452429)

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11. 赤石諭史 (10373010)

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12. 早川秀幸 (10373052)

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13. 秋元正宇 (90287673)

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14. 奥山みなみ (50756781)

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15. 宮川世志幸 (90415604)

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16. 緒方藍歌 (70718311)

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17. 五十嵐勉 (10421190)

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18. 根岸靖幸 (50644580)

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19. 勝山碧 (90803700)

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20. 成尾宗浩 (00772310)

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21. Marcel van der Heyden

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22. Toon van Veen

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Vos Marc

# of Collaborated Projects: 1 results

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24. TOKUMARU Osamu

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# of Collaborated Products: 1 results
25. YAMAZAKI Masatoshi

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26. MIWA Keiko

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27. 松本重清

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28. 北野敬明

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29. 本荘晴朗

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30. 辻幸臣

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31. 小野克重

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32. 森島真幸

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33. 李鍾国

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34. 中井淳一

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35. 守山正胤

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TAKANARI HIROKI 高成 広起

Takanari Hiroki 高成 広起

Research Projects

Research Products

Co-Researchers

Alcohol dehydrogenase in alcohol-related organ disorderOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of magnetic resonance Raman spectrometry for application of optical technology to living bodyPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A new technology for tissue diagnosis with combination of Raman scattering spectrometry and bioimpedance measurementPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

心肺蘇生時の胸部圧迫に伴う心嚢破裂発生機序の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proof of concept study of a novel excess chromosome elimination therapy to ameliorate and prevent trisomy 21 associated complications

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Abnormal transcriptional regulation in Cockayne syndrome and its effect on neuronal differentiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Myocardial regeneration research based on cell-cycle progression of the adult myocyte

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of fetal gene reprogramming on expression, distribution and expression of gap junction in failing heartsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa , are I Kr blockers with proarrhythmic effects in vitro and in vivo2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin 10 Treatment Ameliorates High-Fat Diet?Induced Inflammatory Atrial Remodeling and Fibrillation2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Testosterone-mediated upregulation of delayed rectifier potassium channel in cardiomyocytes causes abbreviation of QT intervals in rats2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Response to the letter from Warren et al.2017

Author(s)

Journal Title

TAKANARI HIROKI 高成広起

Takanari Hiroki 高成広起

[Journal Article] ジギタリスー伝統的薬剤を現代医療でどのように用いるか2016