Nakashima Masahiro 中島正裕

… Alternative Names

NAKASHIMA Masahiro 中島正裕

Less

Researcher Number	70738103
Affiliation (Current)	2025: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 免疫・微生物学, 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 免疫・微生物学, 助教 2016: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 免疫・微生物学, 助教 2014 – 2015: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 助教
Review Section/Research Field	Principal Investigator General pharmacology / Experimental pathology Except Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 52030:Psychiatry-related / Basic Section 49030:Experimental pathology-related / Experimental pathology
Keywords	Principal Investigator 貪食能 / 好中球 / マクロファージ / 細菌 / アセトアミノフェン / Kupffer細胞 / 解糖 / 貪食細胞 / 肝臓 / ピオグリタゾン … More / 肺炎球菌 / 特異的抗体 / anti-PPS antibody / anti-PspA antibody / 肺炎球菌表面タンパク / 莢膜多糖類 / 獲得免疫 / 貪食 / B細胞 … More Except Principal Investigator MPLAプレコンディショニン / MPLAプレコンディショニング / compromised host / LXR / NKT細胞 / 非アルコール性脂肪性肝炎 / 自然免疫 / Kupffer細胞 / 敗血症 / PIICS / ストレスレリジエンス / プレコンディショニング / 熱中症 / 熱傷後感染 / trained innate immunity / MLPAプレコンディショニング / 合成CRP / 薬剤感受性迅速診断 / 細菌活性測定チップ / 重症感染症 / 抑うつ症状 / 炎症 / ミクログリア / アストロサイト / エンドトキシン耐性 / リポ多糖 / マイクログリア / Desmosterol / Compromised hosts / 抗菌活性評価チップ / compromised hosts / 薬剤耐性菌敗血症 / Compromised hostｓ / 抗菌活性測定チップ / 貪食細胞機能強化 / LPSプレコンディショニング / 薬剤耐性菌血症 / 免疫学 / CKD / AKI / NASH / NKT cells / Kupffer cells / コレステロール代謝 / 脂質代謝 / マクロファージ Less

Investigation strategy on the induction of resilience against various kinds of host stresses using safe and effective trained innate immunity
- Principal Investigator
  
  木下学
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Defense Medical College
マウス“重症敗血症救命後の病態モデル“の確立と免疫賦活化策や臓器障害軽減策の探索
- Principal Investigator
  
  加藤梓
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Defense Medical College
Multidimensional therapeutic strategy against severe infection/sepsis, focusing on respiratory activity of bacteria and activation of host phagocytic cells
- Principal Investigator
  
  Kinoshita Manabu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Defense Medical College
Analysis of liver immune cells using novel LXR stimulator
- Principal Investigator
  
  Nakashima Hiroyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Defense Medical College
リポ多糖の前投与がミクログリアを介した抑うつ症状の発症を抑制するメカニズムの研究
- Principal Investigator
  
  古賀農人
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Defense Medical College
Novel therapeutic strategy against drug-resistant bacterial sepsis in compromised hosts focusing on enhancing bactericidal activity of macrophages
- Principal Investigator
  
  Kinoshita Manabu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Defense Medical College
Mechanism of augmented phagocytic activity in liver by pioglitazone treatmentPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Masahiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  National Defense Medical College
The function of Kupffer cells in cholesterol metabolism
- Principal Investigator
  
  Nakashima Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  National Defense Medical College
Immunological properties and functions of phagocytic B cellsPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Masahiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Experimental pathology
- Research Institution
  National Defense Medical College

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] Antimicrobial Immune Response2021
- Author(s)
  Hiroyuki Nakashima, Manabu Kinoshita, Masahiro Nakashima
- Publisher
  Intechopen
- ISBN
  9781839687839
- Data Source
  KAKENHI-PROJECT-20K07438
[Journal Article] <scp>l</scp>-Carnitine pretreatment ameliorates heat stress-induced acute kidney injury by restoring mitochondrial function of tubular cells2024
- Author(s)
  Goto Hiroyasu、Nakashima Hiroyuki、Mori Kazuma、Tanoue Keiko、Ito Seigo、Kearney Bradley M.、Kato Azusa、Nakashima Masahiro、Imakiire Toshihiko、Kumagai Hiroo、Kinoshita Manabu、Oshima Naoki
- Journal Title
  
  American Journal of Physiology-Renal Physiology
  
  Volume: 326 Issue: 3 Pages: F338-F351
- DOI
  10.1152/ajprenal.00196.2023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03038
[Journal Article] Antitumor Immunity Exerted by Natural Killer and Natural Killer T Cells in the Liver2023
- Author(s)
  Nakashima Hiroyuki、Kinoshita Manabu
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 12 Issue: 3 Pages: 866-866
- DOI
  10.3390/jcm12030866
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-21H03038
[Journal Article] In?vitro study on the effect of fibrinogen γ-chain peptide-coated ADP-encapsulated liposomes on postcardiopulmonary bypass coagulopathy using patient blood2023
- Author(s)
  Ishida Osamu、Hagisawa Kohsuke、Yamanaka Nozomu、Nakashima Hiroyuki、Kearney Bradley M.、Tsutsumi Koji、Takeoka Shinji、Kinoshita Manabu
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 23 Issue: 7 Pages: 1934-1942
- DOI
  10.1016/j.jtha.2023.03.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-20K17734, KAKENHI-PROJECT-21H03038, KAKENHI-PROJECT-23K24438
[Journal Article] Early treatment with C-reactive protein-derived peptide reduces septic acute kidney injury in mice via controlled activation of kidney macrophages2023
- Author(s)
  Ito Seigo、Goto Hiroyasu、Tanoue Keiko、Koiwai Kazuki、Ishikiriyama Takuya、Kearney Bradley M、Mori Kazuma、Nakashima Masahiro、Nakashima Hiroyuki、Kumagai Hiroo、Seki Shuhji、Kinoshita Manabu、Oshima Naoki
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 113 Issue: 4 Pages: 400-413
- DOI
  10.1093/jleuko/qiad015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-21H03038
[Journal Article] Novel phenotypical and functional sub‐classification of liver macrophages highlights changes in population dynamics in experimental mouse models2023
- Author(s)
  Nakashima Hiroyuki、Kearney Bradley M.、Kato Azusa、Miyazaki Hiromi、Ito Seigo、Nakashima Masahiro、Kinoshita Manabu
- Journal Title
  
  Cytometry Part A
  
  Volume: 103 Issue: 11 Pages: 902-914
- DOI
  10.1002/cyto.a.24783
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03038
[Journal Article] Pioglitazone Modifies Kupffer Cell Function and Protects against Escherichia coli-Induced Bacteremia in Burned Mice2022
- Author(s)
  Miyazaki Hiromi、Kinoshita Manabu、Nakashima Hiroyuki、Nakamura Shingo、Saitoh Daizoh
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 21 Pages: 12746-12746
- DOI
  10.3390/ijms232112746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03785, KAKENHI-PROJECT-21H03038, KAKENHI-PROJECT-20K07438
[Journal Article] Mouse Liver B Cells Phagocytose <i>Streptococcus pneumoniae</i> and Initiate Immune Responses against Their Antigens2022
- Author(s)
  Nakashima Masahiro、Kinoshita Manabu、Nakashima Hiroyuki、Kato Azusa、Mori Kazuma、Koiwai Kazuki、Shinomiya Nariyoshi、Seki Shuhji
- Journal Title
  
  The Journal of Immunology
  
  Volume: 209 Issue: 1 Pages: 26-37
- DOI
  10.4049/jimmunol.2100520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03038, KAKENHI-PROJECT-20K07438
[Journal Article] Effects of L-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy2022
- Author(s)
  Ito Seigo、Nakashima Masahiro、Ishikiriyama Takuya、Nakashima Hiroyuki、Yamagata Akira、Imakiire Toshihiko、Kinoshita Manabu、Seki Shuhji、Kumagai Hiroo、Oshima Naoki
- Journal Title
  
  Kidney and Blood Pressure Research
  
  Volume: 47 Issue: 4 Pages: 277-290
- DOI
  10.1159/000522013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03038, KAKENHI-PROJECT-20K07438
[Journal Article] Early biomarkers for kidney injury in heat-related illness patients: a prospective observational study at Japanese Self-Defense Force Fuji Hospital2022
- Author(s)
  Goto Hiroyasu、Shoda Shinichi、Nakashima Hiroyuki、Noguchi Midori、Imakiire Toshihiko、Ohshima Naoki、Kinoshita Manabu、Tomimatsu Soichi、Kumagai Hiroo
- Journal Title
  
  Nephrology Dialysis Transplantation
  
  Volume: 38 Issue: 3 Pages: 644-654
- DOI
  10.1093/ndt/gfac166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03038, KAKENHI-PROJECT-20K07438
[Journal Article] Heat acclimation ameliorated heat stress-induced acute kidney injury and prevented changes in kidney macrophages and fibrosis2022
- Author(s)
  Goto Hiroyasu、Nakashima Masahiro、Nakashima Hiroyuki、Noguchi Midori、Imakiire Toshihiko、Oshima Naoki、Kinoshita Manabu、Kumagai Hiroo
- Journal Title
  
  American Journal of Physiology-Renal Physiology
  
  Volume: 323 Issue: 3 Pages: F243-F254
- DOI
  10.1152/ajprenal.00065.2022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03038, KAKENHI-PROJECT-20K07438
[Journal Article] Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation2021
- Author(s)
  Ishikiriyama Takuya、Nakashima Hiroyuki、Endo-Umeda Kaori、Nakashima Masahiro、Ito Seigo、Kinoshita Manabu、Ikarashi Masami、Makishima Makoto、Seki Shuhji
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 7 Pages: e0254886-e0254886
- DOI
  10.1371/journal.pone.0254886
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-21H03038
[Journal Article] Generalized Shwartzman reaction as an experimental endotoxin shock model -role of intermediate T cell receptor-expressing innate T lymphocytes in its pathogenesis-2021
- Author(s)
  Kinoshita M, Nakashima M, Seki S, Nakashima H
- Journal Title
  
  Fungal Genomics & Biology
  
  Volume: 11 Pages: 1-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03038
[Journal Article] Microdevice with integrated Clark-type oxygen electrode for measurement of respiratory activity of cells2021
- Author(s)
  Hsueh AJ, Park S, Satoh T, Shimizu T, Koiwai K, Nakashima M, Morimoto Y, Kinoshita M, Suzuki H
- Journal Title
  
  Analytical Chemistry
  
  Volume: 93 Issue: 13 Pages: 5577-5585
- DOI
  10.1021/acs.analchem.1c00227
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-21H03038
[Journal Article] Hepatic Scavenger Receptor Class B Type 1 Knockdown Reduces Atherosclerosis and Enhances the Antiatherosclerotic Effect of Brown Fat Activation in APOE*3-Leiden.CETP Mice2021
- Author(s)
  Zhou Enchen、Li Zhuang、Nakashima Hiroyuki、Liu Cong、Ying Zhixiong、Foks Amanda C.、Berb?e Jimmy F.P.、van Dijk Ko Willems、Rensen Patrick C.N.、Wang Yanan
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 41 Issue: 4 Pages: 1474-1486
- DOI
  10.1161/atvbaha.121.315882
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07438
[Journal Article] Beneficial effects of brown fat activation on top of PCSK9 inhibition with alirocumab on dyslipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice2021
- Author(s)
  Zhou Enchen、Li Zhuang、Nakashima Hiroyuki、Choukoud Ahlam、Kooijman Sander、Berb?e Jimmy F.P.、Rensen Patrick C.N.、Wang Yanan
- Journal Title
  
  Pharmacological Research
  
  Volume: 167 Pages: 105524-105524
- DOI
  10.1016/j.phrs.2021.105524
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07438
[Journal Article] The role of Kupffer cells in systemic anti-microbial defense2021
- Author(s)
  Nakashima H, Nakashima M, Kinoshita M, Seki S
- Journal Title
  
  IntechOpen, Antimicrobial Immune Response
  
  Volume: 1 Pages: 1-13
- DOI
  10.5772/intechopen.97256
- ISBN
  9781839687822, 9781839687839
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-21H03038
[Journal Article] Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy2021
- Author(s)
  Ito Seigo、Nakashima Hiroyuki、Ishikiriyama Takuya、Nakashima Masahiro、Yamagata Akira、Imakiire Toshihiko、Kinoshita Manabu、Seki Shuhji、Kumagai Hiroo、Oshima Naoki
- Journal Title
  
  American Journal of Physiology-Renal Physiology
  
  Volume: 321 Issue: 6 Pages: F757-F770
- DOI
  10.1152/ajprenal.00191.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-21H03038
[Journal Article] Lipopolysaccharide Preconditioning Augments Phagocytosis of Malaria-Parasitized Red Blood Cells by Bone Marrow-Derived Macrophages in the Liver, Thereby Increasing the Murine Survival after Plasmodium yoelii Infection2021
- Author(s)
  Ono Takeshi、Yamaguchi Yoko、Nakashima Hiroyuki、Nakashima Masahiro、Ishikiriyama Takuya、Seki Shuhji、Kinoshita Manabu
- Journal Title
  
  Infection and Immunity
  
  Volume: 89 Issue: 11
- DOI
  10.1128/iai.00249-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07493, KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-21H03038
[Journal Article] The Efficacy of Posttreatment with Synthetic C-Reactive Protein in Murine Bacterial Peritonitis via Activation of FcγRI-Expressing Kupffer Cells2021
- Author(s)
  Kinoshita Manabu、Ito Seigo、Ishikiriyama Takuya、Sekiguchi Kumiko、Yamaguchi Ryota、Tsuruhara Ryoichi、Matsuda Akihisa、Koiwa Kazuki、Nakashima Masahiro、Nakashima Hiroyuki、Miyashita Masao、Seki Shuhji
- Journal Title
  
  Journal of Innate Immunity
  
  Volume: Online ahead Issue: 5 Pages: 1-13
- DOI
  10.1159/000515333
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-21H03038
[Journal Article] Lipopolysaccharide preconditioning reduces liver metastasis of Colon26 cells by enhancing antitumor activity of natural killer cells and natural killer T cells in murine liver2020
- Author(s)
  Nishikawa Makoto、Kinoshita Manabu、Morimoto Yuji、Ishikiriyama Takuya、Nakashima Masahiro、Nakashima Hiroyuki、Ono Takeshi、Seki Shuhji、Moriya Tomoyuki、Yamamoto Junji、Kishi Yoji
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: Online Issue: 7 Pages: 1889-1898
- DOI
  10.1111/jgh.15375
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K10682
[Journal Article] Immune mechanisms underlying susceptibility to endotoxin shock in aged hosts: implication in age-augmented generalized Shwartzman reaction2019
- Author(s)
  Kinoshita M, Nakashima M, Nakashima H, Seki S
- Journal Title
  
  Int J Mol Sci
  
  Volume: 20 Issue: 13 Pages: 3260-3260
- DOI
  10.3390/ijms20133260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K10682
[Journal Article] Pioglitazone improves phagocytic activity of liver recruited macrophages in elderly mice possibly by promoting glucose catabolism2019
- Author(s)
  Nakashima M, Kinoshita M, Nakashima H, Kotani A, Ishikiriyama T, Kato S, Hiroi S, Seki S
- Journal Title
  
  Innate Immun
  
  Volume: 25 Issue: 6 Pages: 356-368
- DOI
  10.1177/1753425919849620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K08611, KAKENHI-PROJECT-17K10682
[Journal Article] The reduced bactericidal activity of neutrophils as an incisive indicator of water-immersion restraint stress and impaired exercise performance in mice2019
- Author(s)
  Kinoshita M, Nakashima, H, Nakashima M, Koga M, Toda H, Koiwi K, Morimoto Y, Miyazaki H, Saitoh D, Suzuki H, Seki S
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 4662-4662
- DOI
  10.1038/s41598-019-41077-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K08611, KAKENHI-PROJECT-17K10682, KAKENHI-PROJECT-17K11602
[Journal Article] On‐site Rapid Detection of Antibacterial Activity of Neutrophils Using Freeze‐Dried Bacteria2019
- Author(s)
  Tanabe Koji、Kinoshita Manabu、Nakashima Masahiro、Kariya Koki、Yokokawa Masatoshi、Morimoto Yuji、Suzuki Hiroaki
- Journal Title
  
  MEDICAL DEVICES & SENSORS
  
  Volume: 00 Issue: 2
- DOI
  10.1002/mds3.10030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02907
[Journal Article] Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice2018
- Author(s)
  Uchida, T. Nakashima, H. Yamagata, A. Ito, S. Ishikiriyama, T. Nakashima, M. Seki, S. Kumagai, H. Oshima, N.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 8225-8225
- DOI
  10.1038/s41598-018-26470-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08751
[Journal Article] Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice2018
- Author(s)
  Endo-Umeda Kaori、Nakashima Hiroyuki、Umeda Naoki、Seki Shuhji、Makishima Makoto
- Journal Title
  
  Endocrinology
  
  Volume: 159 Issue: 3 Pages: 1419-1432
- DOI
  10.1210/en.2017-03141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08751, KAKENHI-PROJECT-16K19061
[Journal Article] Liver X receptors regulate hepatic F4/802018
- Author(s)
  Endo-Umeda, K. Nakashima, H. Komine-Aizawa, S. Umeda, N. Seki, S. Makishima, M.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 9281-9281
- DOI
  10.1038/s41598-018-27615-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08751
[Journal Article] Activated natural killer T cells in mice induce acute kidney injury with hematuria through possibly common mechanisms shared by human CD562018
- Author(s)
  Uchida, T. Nakashima, H. Ito, S. Ishikiriyama, T. Nakashima, M. Seki, S. Kumagai, H. Oshima, N.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 3 Issue: 3 Pages: F618-F627
- DOI
  10.1152/ajprenal.00160.2018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08751
[Journal Article] In vivo Lipopolysaccharide Tolerance Recruits CD11b<sup>+</sup> Macrophages to the Liver with Enhanced Bactericidal Activity and Low Tumor Necrosis Factor-Releasing Capability, Resulting in Drastic Resistance to Lethal Septicemia2017
- Author(s)
  Kinoshita Manabu、Miyazaki Hiromi、Nakashima Hiroyuki、Nakashima Masahiro、Nishikawa Makoto、Ishikiriyama Takuya、Kato Shoichiro、Iwaya Keiichi、Hiroi Sadayuki、Shinomiya Nariyoshi、Seki Shuhji
- Journal Title
  
  Journal of Innate Immunity
  
  Volume: 9 Issue: 5 Pages: 493-510
- DOI
  10.1159/000475931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08751, KAKENHI-PROJECT-15H04315
[Journal Article] Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice.2016
- Author(s)
  Nakashima H, Nakashima M, Kinoshita M, Ikarashi M, Miyazaki H, Hanaka H, Imaki J, Seki S.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 34466-34466
- DOI
  10.1038/srep34466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462773, KAKENHI-PROJECT-16K08751, KAKENHI-PROJECT-26293295
[Presentation] Early biomarkers for kidney injury in heat-related illness patients: A prospective observational study at Japanese Self-Defense Force Fuji Hospital2023
- Author(s)
  Goto H, Shoda S, Nakashima H, Noguchi M, Imakiire T, Oshima N, Kinoshita M, Tomimatsu S, Kumagai H
- Organizer
  Military Health System Research Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03038
[Presentation] マウス広範囲熱傷モデルにおけるミトコンドリアダイナミクスと品質管理機構2022
- Author(s)
  宮﨑　裕美, 木下　学, 中島　弘幸, 秦　裕樹, 齋藤　大蔵, 中村　伸吾
- Organizer
  第 48 回日本熱傷学会総会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] LPS preconditioning が腎マクロファージに与える影響2022
- Author(s)
  田之上　桂子*, 伊藤　誓悟, 後藤　洋康*, 山城　葵*, 福永　継実*, 森　和真*, 中島　正裕, 中島　弘幸, 今給黎　敏彦, 大島　直紀, 木下　学, 熊谷　裕生
- Organizer
  第 65 回日本腎臓学会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] マウスの熱中症による急性腎障害 (AKI) に対する暑熱順化の予防効果2022
- Author(s)
  後藤　洋康*, 中島　正裕, 森　和真*, 中島　弘幸, 福永　継実*, 田之上　桂子*, 山城　葵*, 今給黎　敏彦, 大島　直紀, 木下　学, 熊谷　裕生
- Organizer
  第 65 回日本腎臓学会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] Advanced classification of liver resident and bone marrow-derived macrophages2022
- Author(s)
  Nakashima Hiroyuki,Kato Azusa,Miyazaki Hiromi,Ito Seigo*,Nakashima Masahiro,Kinoshita Manabu
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] 不安および抑うつ様行動発現に対する抑制効果を示すリポ多糖プレコンディショニングは脳内マクロファージの構成を変化させる2022
- Author(s)
  古賀　農人, 戸田　裕之, 中川　隆一, 長峯　正典, 中島　弘幸, 木下　学, 浅井　史穂*, 佐藤　真有実, 松井　茉莉江*, 三井　由美*, 吉野　相英
- Organizer
  第 41 回躁うつ病の薬理生化学的研究懇話会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] Lipopolysaccharide pre-conditioning upregulates renal macrophage function and ameliorates acute kidney injury associated with Staphylococcus aureus bacteremia2022
- Author(s)
  Tanoue Keiko,Nakashima Hiroyuki,Ito Seigo,Goto Hiroyasu,Mori Kazuma,Koiwai Kazuki,Kato Azusa,Nakashima Masahiro,Oshima Naoki,Kinoshita Manabu
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] Lipopolysaccharide pre-conditioning enhances the bactericidal activity of Kupffer cells in mice2022
- Author(s)
  中島　弘幸, 加藤　梓,Kearny Bradley*, 中島　正裕, 木下　学
- Organizer
  日本細菌学会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] Heat acclimation ameliorated heat stress-induced acute kidney injury by preserving the number of resident macrophages in mice2022
- Author(s)
  Goto Hiroyasu*,Nakashima Hiroyuki,Ito Seigo*,Mori Kazuma*,Tanoue Keiko*,Kato Azusa,Nakashima Masahiro,Oshima Naoki,Kinoshita Manabu
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] Sustained reduction of alveolar macrophages predisposes the post-intensive care syndrome after successful treatment of sever peritonitis in mice2022
- Author(s)
  加藤　梓, 中島　弘幸, 森　和真*, 田之上　桂子*, 後藤　洋康*, 小岩井　和樹*, 中島　正裕, 木下　学
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] 合成 CRP による腎マクロファージ活性化を介した敗血症性急性腎傷害 (Septic AKI) の改善効果2022
- Author(s)
  伊藤　誓悟, 中島　弘幸, 加藤　梓*, 大島　直紀, 木下　学
- Organizer
  第 36 回日本 Shock 学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] Identification of Kupffer cell subsets in mice2021
- Author(s)
  Hiroyuki Nakashima
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] 合成CRP による腎マクロファージ活性化を介した敗血症性急性腎傷害の治療効果2020
- Author(s)
  伊藤誓悟, 木下学, 中島正裕, 中島弘幸
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] 糖尿病性腎症マウスモデルにおける腎限局低線量放射線照射の治療効果2020
- Author(s)
  伊藤誓悟, 木下学, 中島正裕, 中島弘幸
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] Pioglitazone reinforces liver innate immunity against bacterial infection in aged mice.2020
- Author(s)
  Nakashima Masahiro, Kinoshita Manabu, Nakashima Hiroyuki, Seki Shuhji.
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K08611
[Presentation] 糖尿病性腎症マウスモデルにおけるL-カルニチン投与による尿蛋白減少とミトコンドリア機能改善2020
- Author(s)
  山形瑛, 木下学, 中島正裕, 中島弘幸
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-20K07438
[Presentation] Pioglitazone prevents sepsis in old mice by enhancing liver innate immunity2018
- Author(s)
  Nakashima Masahiro
- Organizer
  第47回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K08611
[Presentation] LPS プレコンディショニングによる肝マクロファージの殺菌能増強とグラム陰性陽性両敗血症への救命効果2018
- Author(s)
  木下　学, 宮﨑　裕美, 中島　正裕, 中島　弘幸 , 石切山　拓也, 加藤　章一郎, 四ノ宮　成祥, 関　修司
- Organizer
  日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] LPS preconditioningによる抗腫瘍活性増強効果と外科周術期管理での有用性2018
- Author(s)
  木下学、西川誠、中島正裕、中島弘幸、関修司
- Organizer
  日本エンドトキシン自然免疫研究会
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] LPS preconditioning potently enhances liver antitumor activity in mice despite marked suppression of inflammatory response2018
- Author(s)
  Kinoshita M, Nishikawa M, Nakashima H, Nakashima M, Ishikiriyama T, Kato S, Seki S
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] Liver X Receptor activation exerts the different effects on the function of liver resident Kupffer cells and recruited macrophages2018
- Author(s)
  Takuya Ishikiriyama, Hiroyuki Nakashima, Shoichiro Kato, Kori Endo-Umeda, Masahiro Nakashima, Manabu Kinoshita, Makoto Makishima, Shuhji Seki
- Organizer
  2018年度　日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Pioglitazone prevents sepsis in old mice by enhancing liver innate immunity2018
- Author(s)
  Masahiro Nakashima, Hiroyuki Nakashima, Manabu Kinoshita, Takuya Ishikiriyama, Shoichiro Kato, Shuhji Seki
- Organizer
  2018年度　日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] LPS preconditioning potently enhances liver antitumor activity in mice despite marked suppression of inflammatory response2018
- Author(s)
  Manabu Kinoshita, Hiroyuki Nakashima, Masahiro Nakashima, Takuya Ishikiriyama, Shoichiro Kato, Hiromi Miyazaki
- Organizer
  2018年度　日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] LPS tolerance を用いたグラム陰性陽性両敗血症に対する救命治療戦略の可能性2017
- Author(s)
  木下　学, 宮﨑　裕美, 中島　正裕, 中島　弘幸 , 萩沢　康介, 関　修司
- Organizer
  日本Shock 学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Liver sinusoidal endothelial cells and resident Kupffer cells are involved in cholesterol metabolism in mice2017
- Author(s)
  Nakashima Hiroyuki, Kato Shoichiro, Ishikiriyama Takuya, Nakashima Masahiro, Kinoshita Manabu, Seki Shuhji
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Medical countermeasures using LPS tolerance to address lethal toxic shock and fatal bacterial sepsis2017
- Author(s)
  Manabu Kinoshita, Nariyoshi Shinomiya, Hiromi Miyazaki, Hiroyuki Nakashima , Masahiro Nakashima, ShujiSeki
- Organizer
  Chemical and Biological Defense Science & Technology Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Repeated administrations of α- galactosylceramide slow the progression of lupus nephritis in BWF1 mice2017
- Author(s)
  Nakashima Masahiro, Uchida Takahiro, Ito Seigo, Ishikiriyama Takuya, Nakashima Hiroyuki, Kumagai Hiroo, Seki Shuhji
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] LPS tolerance recruits CD11b+ macrophages to the liver with enhanced bactericidal activity and low TNF-releasing capability, resulting in drastic resistance to lethal septicemia2017
- Author(s)
  Kinoshita Manabu, Miyazaki Hiromi, Nakashima Masahiro, Nakashima Hiroyuki, Ishikiriyama Takuya, Kato Shoichiro, Shinomiya Nariyoshi, Seki Shuhji
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] In vivo LPS tolerance recruits CD11b+ macrophages to the liver with enhanced bactericidal activity and low TNFreleasing capability, resulting in drastic resistance to lethal septicemia2017
- Author(s)
  Kinoshita Manabu, Miyazaki Hiromi, Nakashima Hiroyuki, Nakashima Masahiro, Nishikawa Makoto, Hagisawa Kohsuke, Seki Shuhji
- Organizer
  2017 Shock Society： Shock 47
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Excessive activation of liver natural killer cells and phenotypic alteration and dysfunction of Kupffer cells in diabetic mice with sepsis, and reversal by insulin treatment2016
- Author(s)
  Kinoshita,M. Miyazaki, H. Nakashima, H. Nakashima, M. Seki, S.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice2016
- Author(s)
  Nakashima, H. Nakashima, M. Kinoshita,M. Seki, S.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Activation of PPAR gamma protects against postburn infection by regulating innate immune response2016
- Author(s)
  Miyazaki, H. Kinoshita,M. Nakashima, H. Nakashima, M. Seki, S.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08751

1. Kinoshita Manabu (70531391)

# of Collaborated Projects: 8 results

# of Collaborated Products: 54 results
2. Nakashima Hiroyuki (10574064)

# of Collaborated Projects: 7 results

# of Collaborated Products: 60 results
3. Seki Shuhji (80531392)

# of Collaborated Projects: 5 results

# of Collaborated Products: 29 results
4. 宮崎裕美 (30531636)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. Shinomiya Nariyoshi (40505260)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 鈴木博章 (20282337)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. 小野聡 (30531355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 小野岳史 (20535182)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. Nakanishi Kuniaki (60523115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 石塚俊晶 (30399117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 守本祐司 (10449069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 武岡真司 (20222094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 齋藤大蔵 (90531632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 古賀農人 (70744936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 戸田裕之 (00610677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 佐藤泰司 (10505267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 太田宏之 (20535190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 熊谷裕生 (50170048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
19. 菅谷健 (40381561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 今給黎敏彦 (40971768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. カーニーブラッドリー (80990770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 加藤梓 (10581241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 小山薫 (60186830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 佐藤仁哉 (90801845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nakashima Masahiro 中島 正裕

NAKASHIMA Masahiro 中島 正裕

Research Projects

Research Products

Co-Researchers

Investigation strategy on the induction of resilience against various kinds of host stresses using safe and effective trained innate immunity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マウス“重症敗血症救命後の病態モデル“の確立と免疫賦活化策や臓器障害軽減策の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multidimensional therapeutic strategy against severe infection/sepsis, focusing on respiratory activity of bacteria and activation of host phagocytic cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of liver immune cells using novel LXR stimulator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

リポ多糖の前投与がミクログリアを介した抑うつ症状の発症を抑制するメカニズムの研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapeutic strategy against drug-resistant bacterial sepsis in compromised hosts focusing on enhancing bactericidal activity of macrophages

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of augmented phagocytic activity in liver by pioglitazone treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The function of Kupffer cells in cholesterol metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunological properties and functions of phagocytic B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Antimicrobial Immune Response2021

Author(s)

Publisher

ISBN

Data Source

[Journal Article] <scp>l</scp>-Carnitine pretreatment ameliorates heat stress-induced acute kidney injury by restoring mitochondrial function of tubular cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor Immunity Exerted by Natural Killer and Natural Killer T Cells in the Liver2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In?vitro study on the effect of fibrinogen γ-chain peptide-coated ADP-encapsulated liposomes on postcardiopulmonary bypass coagulopathy using patient blood2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Early treatment with C-reactive protein-derived peptide reduces septic acute kidney injury in mice via controlled activation of kidney macrophages2023

Nakashima Masahiro 中島正裕

NAKASHIMA Masahiro 中島正裕