Ikenaka Kensuke 池中建介

Researcher Number	70774058
Other IDs	https://orcid.org/0000-0002-5559-1966
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 大阪大学, 大学院医学系研究科, 助教 2017 – 2019: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Medium-sized Section 51:Brain sciences and related fields / Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Broad Section D / Basic Section 52020:Neurology-related
Keywords	Principal Investigator αシヌクレイン / バイオマーカー / アルギニンジメチル化 / メチル化蛋白質 / パーキンソン / フィブリル / シヌクレイン / エクソソーム / 伝播 / alpha synuclein / パーキンソン病 … More Except Principal Investigator … More 蛋白質凝集 / αシヌクレイン / 機能的アミロイド / PIP3 / 多系統萎縮症 / パーキンソン病 / 疾患構造多型 / 構造多型 / メタボローム / イメージング / 脳機能ネットワーク / 脳機能攪乱検出法 / シグナル毒性 / 超解像 / 細胞 / 超音波 / 深層学習 / 力学刺激 / 核 / 集束超音波 / メカノバイオロジー / 局所翻訳 / 神経軸索 / 前頭側頭葉変性症 / 筋萎縮性側索硬化症 Less

Deep-learning generation of high-resolution ultrasound images of cultured cells and systematic study of local mechanical stimulation on them by focused ultrasound and their responses
- Principal Investigator
  
  荻博次
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section D
- Research Institution
  The University of Osaka
Creation of a platform for the evaluation of signal toxicity, starting with the development of methods for the detection and diagnosis of brain function disruption.
- Principal Investigator
  
  池中良徳
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Hokkaido University
Two Dimensions of Physiological and Pathological Activities of Synuclein Amyloid Fibrils
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Osaka University
アルギニンジメチル化異常が与えるALS病態の解明と新規病態関連因子の同定Principal Investigator
- Principal Investigator
  
  池中建介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Elucidate the pathomechanisms of alpha synuclein polymorphinsms imparts disease dievrsities
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka University
Elucidation of the pathogenesis and development of the treatment strategy of ALS/FTLD focusing on the local translation in neuronal axons
- Principal Investigator
  
  長野清一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Reveal the mechanisms of aSyn transmission via exosome in PD patientsPrincipal Investigator
- Principal Investigator
  
  Ikenaka Kensuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University

All 2023 2022 2019

All Journal Article Presentation

[Journal Article] A Comparative Genomic and Phylogenetic Investigation of the Xenobiotic Metabolism Enzymes of Cytochrome P450 in Elephants Shows Loss in CYP2E and CYP4A.2023
- Author(s)
  Kanami Watanabe, Mitsuki Kondo, Yoshinori Ikenaka, Shouta M. M. Nakayama, Mayumi Ishizuka.
- Journal Title
  
  Animals
  
  Volume: 13 Issue: 12 Pages: 1939-1939
- DOI
  10.3390/ani13121939
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04919, KAKENHI-PROJECT-23H00512
[Journal Article] Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane2023
- Author(s)
  Ito Naohito、Tsuji Mayumi、Adachi Naoki、Nakamura Shiro、Sarkar Avijite Kumer、Ikenaka Kensuke、Aguirre Cesar、Kimura Atsushi Michael、Kiuchi Yuji、Mochizuki Hideki、Teplow David B.、Ono Kenjiro
- Journal Title
  
  npj Parkinson's Disease
  
  Volume: 9 Issue: 1 Pages: 139-139
- DOI
  10.1038/s41531-023-00583-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18255, KAKENHI-PROJECT-20K19685, KAKENHI-PROJECT-22K07514, KAKENHI-PROJECT-22K09918, KAKENHI-PROJECT-19K07965, KAKENHI-PLANNED-23H03850, KAKENHI-PROJECT-23K24212
[Journal Article] Biological effects related to exposure to polychlorinated biphenyl (PCB) and decabromodiphenyl ether (BDE-209) on cats2023
- Author(s)
  Khidkhan Kraisiri、Mizukawa Hazuki、Ikenaka Yoshinori、Nakayama Shouta M. M.、Nomiyama Kei、Yokoyama Nozomu、Ichii Osamu、Takiguchi Mitsuyoshi、Tanabe Shinsuke、Ishizuka Mayumi
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 1 Pages: e0277689-e0277689
- DOI
  10.1371/journal.pone.0277689
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00512
[Journal Article] Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor2023
- Author(s)
  Zhou Lianjie、Hajiri Touko、Nakajima Kichitaro、Aguirre Cesar、Ikenaka Kensuke、Mochizuki Hideki、Yamaguchi Keiichi、Goto Yuji、Ogi Hirotsugu
- Journal Title
  
  ACS Sensors
  
  Volume: 8 Issue: 7 Pages: 2598-2608
- DOI
  10.1021/acssensors.3c00331
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14013, KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-23K23848, KAKENHI-PROJECT-23K24212
[Journal Article] Sulfotransferases (SULTs), enzymatic and genetic variation in Carnivora: Limited sulfation capacity in pinnipeds2023
- Author(s)
  Kondo Mitsuki、Ikenaka Yoshinori、Nakayama Shouta M.M.、Kawai Yusuke K.、Mizukawa Hazuki、Mitani Yoko、Nomyama Kei、Tanabe Shinsuke、Ishizuka Mayumi
- Journal Title
  
  Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology
  
  Volume: 263 Pages: 109476-109476
- DOI
  10.1016/j.cbpc.2022.109476
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00512
[Journal Article] Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism2023
- Author(s)
  Choong Chi-Jing、Aguirre Cesar、Kakuda Keita、Beck Goichi、Nakanishi Hiroki、Kimura Yasuyoshi、Shimma Shuichi、Nabekura Kei、Hideshima Makoto、Doi Junko、Yamaguchi Keiichi、et al.
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 145 Issue: 5 Pages: 573-595
- DOI
  10.1007/s00401-023-02555-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-23K24212, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K15709, KAKENHI-PROJECT-22K07516, KAKENHI-PROJECT-22K07538, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K23848
[Journal Article] Investigation of dichlorodiphenyltrichloroethane (DDT) on xenobiotic enzyme disruption and metabolomic bile acid biosynthesis in DDT-sprayed areas using wild rats2023
- Author(s)
  MOTOHIRA Kodai、YOHANNES Yared Beyene、IKENAKA Yoshinori、EGUCHI Akifumi、NAKAYAMA Shouta MM、WEPENER Victor、SMIT Nico J、VAN VUREN Johan HJ、ISHIZUKA Mayumi
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 85 Issue: 2 Pages: 236-243
- DOI
  10.1292/jvms.22-0490
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0163, KAKENHI-PROJECT-20J21282, KAKENHI-PROJECT-22K18425, KAKENHI-PROJECT-23H00512
[Journal Article] Effects of Diazinon Exposure on Urinary Shedding of Leptospira interrogans Serogroup Hebdomadis in Mice2023
- Author(s)
  Shinya So、Muthusinghe Devinda S.、Koizumi Nobuo、Yoshimatsu Kumiko、Nakayama Shouta M. M.、Ishizuka Mayumi、Ikenaka Yoshinori
- Journal Title
  
  Toxics
  
  Volume: 11 Issue: 4 Pages: 361-361
- DOI
  10.3390/toxics11040361
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18425, KAKENHI-PROJECT-23H00512
[Journal Article] Surveys of eleven species of wild and zoo birds and feeding experiments in white-tailed eagles reveal differences in the composition of the avian gut microbiome based on dietary habits between and within species2023
- Author(s)
  Kohei Ogasawara, Naoki Yamada, Shouta MM Nakayama, Yukiko Watanabe, Keisuke Saito, Akane Chiba, Yoshitake Uchida, Kaoru Ueda, Yasunori Takenaka, Kentaro Kazama, Mami Kazama, Junya Yamagishi, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 85 Issue: 12 Pages: 1355-1365
- DOI
  10.1292/jvms.23-0138
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04919, KAKENHI-PROJECT-23H00512, KAKENHI-PROJECT-23K25009
[Journal Article] Status Report on Neonicotinoid Pollution in Japan: Emphasis on Human, Animal, and Environmental Health2023
- Author(s)
  NIMAKO Collins、NAKAYAMA Shouta M. M.、YOHANNES Yared Beyene、IKENAKA Yoshinori、ISHIZUKA Mayumi
- Journal Title
  
  Environmental Monitoring and Contaminants Research
  
  Volume: 3 Issue: 0 Pages: 69-91
- DOI
  10.5985/emcr.20230004
- ISSN
  2435-7685
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18425, KAKENHI-PROJECT-22KK0163, KAKENHI-PROJECT-23H00512
[Journal Article] Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles2023
- Author(s)
  Kakuda Keita、Ikenaka Kensuke、Kuma Akiko、Doi Junko、Aguirre Cesar、Wang Nan、Ajiki Takahiro、Choong Chi-Jing、Kimura Yasuyoshi、Badawy Shaymaa Mohamed Mohamed、Shima Takayuki、Nakamura Shuhei、Baba Kousuke、Nagano Seiichi、Nagai Yoshitaka、Yoshimori Tamotsu、Mochizuki Hideki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 1
- DOI
  10.1073/pnas.2312306120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18255, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K15709, KAKENHI-PROJECT-22KJ2105, KAKENHI-PROJECT-22K07516, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PLANNED-21H05145, KAKENHI-PROJECT-22H04982, KAKENHI-PROJECT-21H02428, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K24212
[Journal Article] Association between chronic environmental lead (Pb) exposure and cytokines in males and females of reproductive age from Kabwe, Zambia.2023
- Author(s)
  Andrew Kataba, Yared Beyene Yohannes, Hokuto Nakata, John Yabe, Haruya Toyomaki, Kaampwe Muzandu, Golden Zyambo, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka, Shouta MM Nakayama
- Journal Title
  
  Int. J. Environ. Res. Public Health.
  
  Volume: 20 Issue: 8 Pages: 5596-5596
- DOI
  10.3390/ijerph20085596
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0163, KAKENHI-PROJECT-23H00512, KAKENHI-PROJECT-23K28235
[Journal Article] Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease2022
- Author(s)
  Hideshima Makoto、Kimura Yasuyoshi、Aguirre Cesar、Kakuda Keita、Takeuchi Toshihide、Choong Chi-Jing、Doi Junko、Nabekura Kei、Yamaguchi Keiichi、Nakajima Kichitaro、Baba Kousuke、Nagano Seiichi、Goto Yuji、Nagai Yoshitaka、Mochizuki Hideki、Ikenaka Kensuke
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 351-351
- DOI
  10.1038/s41598-021-04131-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17034, KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-21H02841
[Journal Article] piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis2022
- Author(s)
  Abdelhamid Rehab F.、Ogawa Kotaro、Beck Goichi、Ikenaka Kensuke、Takeuchi Eriko、Yasumizu Yoshiaki、Jinno Jyunki、Kimura Yasuyoshi、Baba Kousuke、Nagai Yoshitaka、Okada Yukinori、Saito Yuko、Murayama Shigeo、Mochizuki Hideki、Nagano Seiichi
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 59 Issue: 3 Pages: 1693-1705
- DOI
  10.1007/s12035-021-02686-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-22K07538, KAKENHI-PROJECT-22K07550, KAKENHI-PROJECT-19K07988, KAKENHI-PROJECT-21H02841, KAKENHI-PROJECT-22H04923
[Journal Article] Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.2022
- Author(s)
  Ikenaka K, Maeda Y, Hotta Y, Nagano S, Yamada S, Ito D, Torii R, Kakuda K, Tatebe H, Atsuta N, Aguirre C, Kimura Y, Baba K, Tokuda T, Katsuno M, Kimura K, Sobue G, Mochizuki H.
- Journal Title
  
  Eur J Neurol.
  
  Volume: 29（5） Issue: 5 Pages: 1410-1416
- DOI
  10.1111/ene.15254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-21H02841
[Journal Article] Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid.2019
- Author(s)
  2. Kakuda K, Ikenaka K, Araki K, So M, Aguirre C, Kajiyama Y, Konaka K, Noi K, Baba K, Tsuda H, Nagano S, Ohmichi T, Nagai Y, Tokuda T, El-Agnaf O, Ogi H, Goto Y, Mochizuki H.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 6001-6001
- DOI
  10.1038/s41598-019-42399-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-17K16122, KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-16K09716, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-18H02718, KAKENHI-PROJECT-18H02741
[Presentation] Evaluation of a highly sensitive analytical method for monoamine neurotransmitters using mass spectrometry ~Evaluation of neurotoxicity of neonicotinoid insecticides~2023
- Author(s)
  Yoshinori Ikenaka, Anri Hirai, Ryo Yamazaki, Atsushi Kobayashi, Takashi Kimura, Kei Nomiyama, Shuuichi Shimma, Shouta M.M. Nakayama, Mayumi Ishizuka
- Organizer
  8th One Health Lecture Series: Enhance Scientific Collaboration for Healthier Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00512
[Presentation] 低濃度DDTが実験ラットの血漿ステロイドホルモンに及ぼす多世代影響の評価2023
- Author(s)
  河田あおい、本平航大、ヤレドベイェネ、中山翔太、池中良徳、石塚真由美
- Organizer
  第２回環境化学物質3学会合同大会
- Data Source
  KAKENHI-PROJECT-23H00512
[Presentation] 多世代曝露試験による低濃度ジクロロジフェニルトリクロロエタンとその代謝物の肝臓への影響評価2023
- Author(s)
  本平航大、ヤレドベイェネ、河田あおい、新坊弦也、水野雄貴、中山翔太、殷熙洙、石塚真由美、池中良徳
- Organizer
  第２回環境化学物質3学会合同大会
- Data Source
  KAKENHI-PROJECT-23H00512
[Presentation] Toxicity assesment of neonicotinoid-exposed mice using mass spectrometry2023
- Author(s)
  Tomoya Koike, Anri Hirai, Kei Nomiyama, Akifumi Eguchi, Nobuhiko Hoshi, Tetsushi Hirano, Collins Nimako, Yared Beyene, Mai Tamba, Shouta M.M. Nakayama , Mayumi Ishizuka, Yoshinori Ikenaka
- Organizer
  7th International Chemical Hazard Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00512
[Presentation] A case of familial ALS with a novel mutation in the ANXA11 gene.2023
- Author(s)
  Nagano S, Ogawa K, Sakurai R, Ozono T, Ikenaka K, Mochizuki H.
- Organizer
  34th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] A case of familial ALS with a novel mutation in the ANXA11 gene.2023
- Author(s)
  Nagano S, Ogawa K, Sakurai R, Ozono T, Ikenaka K, Mochizuki H.
- Organizer
  Pan-Asian Consortium for Treatment and Research in ALS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02841
[Presentation] ネオニコチノイド投与による脳内モノアミンの変動と行動2023
- Author(s)
  平井杏梨、Yared Beyene Yohannes、Collins Nimako、丹場舞、野見山桂、江口哲史、星信彦、平野哲史、中山翔太、石塚真由美、池中良徳
- Organizer
  第２回環境化学物質3学会合同大会
- Data Source
  KAKENHI-PROJECT-23H00512
[Presentation] 北海道大学One Healthリサーチセンターの教育および研究活動の紹介2023
- Author(s)
  池中良徳
- Organizer
  愛媛大学One Healthシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23H00512

1. 望月秀樹 (90230044)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 角田渓太 (20815500)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. AGUIRRE・MARTINEZ CESAR (20865597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 長野清一 (40362727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 永井義隆 (60335354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 荻博次 (90252626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中島吉太郎 (20867337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 池中良徳 (40543509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
9. 星信彦 (10209223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 野見山桂 (30512686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. 杉尾翔太 (30825344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 石塚真由美 (50332474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
13. 戸田知得 (70571199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 江口哲史 (70595826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 平野哲史 (70804590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 中山翔太

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. 別宮豪一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 山口圭一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 熱田直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 祖父江元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ikenaka Kensuke 池中 建介

Research Projects

Research Products

Co-Researchers

Deep-learning generation of high-resolution ultrasound images of cultured cells and systematic study of local mechanical stimulation on them by focused ultrasound and their responses

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creation of a platform for the evaluation of signal toxicity, starting with the development of methods for the detection and diagnosis of brain function disruption.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Two Dimensions of Physiological and Pathological Activities of Synuclein Amyloid Fibrils

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルギニンジメチル化異常が与えるALS病態の解明と新規病態関連因子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidate the pathomechanisms of alpha synuclein polymorphinsms imparts disease dievrsities

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathogenesis and development of the treatment strategy of ALS/FTLD focusing on the local translation in neuronal axons

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Reveal the mechanisms of aSyn transmission via exosome in PD patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Comparative Genomic and Phylogenetic Investigation of the Xenobiotic Metabolism Enzymes of Cytochrome P450 in Elephants Shows Loss in CYP2E and CYP4A.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biological effects related to exposure to polychlorinated biphenyl (PCB) and decabromodiphenyl ether (BDE-209) on cats2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sulfotransferases (SULTs), enzymatic and genetic variation in Carnivora: Limited sulfation capacity in pinnipeds2023

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[Journal Article] Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism2023

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[Journal Article] Investigation of dichlorodiphenyltrichloroethane (DDT) on xenobiotic enzyme disruption and metabolomic bile acid biosynthesis in DDT-sprayed areas using wild rats2023

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Ikenaka Kensuke 池中建介