SHIMIZU Takeshi 清水猛

Researcher Number	80087569
Affiliation (based on the past Project Information) *help	2009: 独立行政法人理化学研究所, 化学情報・化合物創製チーム, 特別嘱託職員 2008: 独立行政法人理化学研究所, 袖岡有機合滅化学研究室, 副主任研究員 2004 – 2007: 独立行政法人理化学研究所, 袖岡有機合成化学研究室, 副主任研究員 2005: RIKEN, Synthetic Organic Chemistry Laboratory, Senior Scientist, 神岡有機合成化学研究室, 副主任研究員 2003: RIKEN (The Institute of Physical and Chemical Research), Synthetic Organic Chemistry Laboratory, Senior Scientist, 有機合成化学研究室, 副主任研究員 … More 2001 – 2002: RIKEN(The Institute of Physical and Chemical Reseach), Synthetic Organic Chemistry Laboratory, Senior Scientist, 有機合成化学研究室, 副主任研究員 1998 – 2000: 理化学研究所, 有機合成化学研究室, 先任研究員 1996: Institute of Physical and Chmical Research, Synthetic Organic Chemistry Laborato, 有機合成化学研究室, 先任研究員 1995: 理化学研究所, 有機合成化学研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Chemical pharmacy / Chemical pharmacy / 医薬分子機能学 Except Principal Investigator 医薬分子機能学
Keywords	Principal Investigator リベロマイシンA / bioprobe / バイオプローブ / reveromycin A / 6,6-スピロアセタール / spirofungin A / スピロファンジンB / スピロファンジンA / 6,6-spiroacetal / 構造活性相関 … More / トリカルボン酸 / asymmetric total synthesis / anti-tumor agent / inhibitor of protein synthesis / inhibitor of eukaryotic cell growth / 6,6-スピロケタール / 不斉全合成 / 抗腫瘍剤 / 上皮増殖因子阻害剤 / structure-activity relationship / osteoclast / isoleucyl-tRNA svnthetase / 6.6-spiroketal / spirofuneinB / reveromvcin A / 抗生物質 / 1,2-ジヒドロリベロマイシン / 破骨細胞 / イソロイシンtRNAシンテターゼ / absolute configuration / antifungal antibiotics / spirofungin B / ワインレブアミド / 6,6-スピロマイシンA / 絶対立体配置 / 抗かび抗生物質 / therapeutic drug for hypercalcemia / tri-carboxylic acids / トルカルボン酸 / 高カルシウム血症治療剤 / タンパク質合成阻害剤 / reaction under high pressure / succinylation / 6, 6-spiroacetal / Julia olefination / 超高圧反応 / サクシニル化 / 蛋白合成阻害剤 / nitrile / carbon-nitrogen bond formation / azide / rearrangement of carbon-carbon bond / invertion of secondary alcohol / monochlate / chloromethanesulfonate / rearrangement-ring expansion of cyclic ether / 炭素-炭素結合の転位反応 / 炭素-窒素結合形成反応 / 二級水酸基の反転反応 / ビシクロオキソニウムイオン / オキセパン / 環状エーテルの転位-環拡大反応 / 炭素-炭素結合形成反応 / テトラヒドロピラン / 環状エーテルの転位ー環拡大反応 / ニトリル / 炭素ー窒素結合形成反応 / アジド / 炭素ー炭素結合の転位反応 / 水酸基の反転反応 / モノクレート / クロロメタンスルフォネート … More Except Principal Investigator antiobesity / antihyperlipidemia / cholestenone / 肥満 / エノン化合物 / トリグリセライド / コレステロール / 血清脂質 / cholest-4-en-3-one / 抗肥満 / 抗高脂血症 / コレステノン / 標的分子 / 結晶構造解析 / 低分子化合物 / ライブラリー / 化合物アレイ / リガンド / 受容体 / 相互作用 / 蛋白質 / バイオプローブ / 構造生物学 / 化学生物学 Less

Synthesis and Biological Evaluation of Spiroketal DerivativesPrincipal Investigator
- Principal Investigator
  
  TAKESHI Shimizu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
Chemical proteomics to reveal interaction between chemicals and proteins at angstrom level
- Principal Investigator
  
  OSADA Hiroyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  The Institute of Physical and Chemical Research
Synthesis and Biological Evaluation of Antifungal Antibiotics, Spirofungin A and BPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  RIKEN
Studies for Structure-Activities Relationships of Reveromycin A : An Inhibitor of Eukaryotic Cell GrowthPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  RIKEN (The Institute of Physical and Chemical Research)
Synthetic Studies of Reveromycin A : An Inhibitor of Eukaryotic Cell GrowthPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  RIKEN (The Institute of Physical and Chemical Reseach)
DEVELOPMENT OF USEFUL REACTIONS USING THE NOVEL LEAVING GROUP, MONOCHLATEPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  RIKEN (The Institute of Physical and Chemical Research)
Antihyperlipidemic and anti-obesity effects of cholesteone
- Principal Investigator
  
  SUZUKI Kunio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Institute of Physical and Chemical Research (RIKEN)

All 2009 2008 2007 2006 2005

All Journal Article Presentation Book

[Book] 化合物アレイを用いた抗がん剤探索系「がん分子標的治療研究実践マニュアル(日本がん分子標的治療学会編)」2009
- Author(s)
  清水史郎, 他
- Total Pages
  340
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-17GS0221
[Book] がんの分子標的治療第III部 25「浸潤と転移-1 タンパク質分解酵素と糖分解酵素」2008
- Author(s)
  清水史郎, 他
- Total Pages
  441
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] 分子細胞学的解析2009
- Author(s)
  清水史郎, 他
- Journal Title
  
  日本臨牀 67
  
  Pages: 143-147
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] 6, 6-スピロケタール天然物reveromycin A, Bおよびspirofungin A, Bの合成と活性2009
- Author(s)
  清水猛
- Journal Title
  
  有機合成化学協会誌 2009
  
  Pages: 51-66
- NAID
  10023983974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] Synthesis and Biological Activities of Reveromycin A and Spirofungin A Derivatives2008
- Author(s)
  Takeshi Shimizu
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590027
[Journal Article] Synthesis and Biological Activities of Reveromycin A and Spirofungin A Derivatives2008
- Author(s)
  Takeshi Shimizu
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18(In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590027
[Journal Article] A new route for the preparation of succinates2008
- Author(s)
  Shimizu, T., et al.
- Journal Title
  
  Synthesis 2008
  
  Pages: 3209-3218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] Synthesis and biological activities of reveromycin A and spirofungin A derivatives2008
- Author(s)
  Shimizu T., et al.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 3756-3760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] Synthesis and biological activities of reveromycin A and spirofungin a derivatives.2008
- Author(s)
  Shimizu, T. (10名中1番目), Usui, T. (10名中2番目), Osada, H. (10名中9番目)
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 3756-3760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] Asymmetric Total Synthesis of (-)-SpirofunginA and (+)-SpirofunginB2006
- Author(s)
  Shimizu, T., Satoh, T., Murakoshi, K., Sodeoka, M.
- Journal Title
  
  Organic Letters 7
  
  Pages: 5573-5576
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590026
[Journal Article] Asymmetric total synthesis of (-)-spirofungin A and (+)-spirofungin B2005
- Author(s)
  Takeshi Shimizu et al.
- Journal Title
  
  Organic Letters 7
  
  Pages: 5573-5576
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590026
[Presentation] Total synthesis of himeic acid A.2009
- Author(s)
  清水史郎
- Organizer
  The 22nd International Congress on Heterocyclic Chemistry(ICHC-22)
- Place of Presentation
  St.John's, NL, Canada
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] 最先端創薬システム:分子標的治療薬開発のためのケミカルバイオロジー2009
- Author(s)
  清水史郎
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島(徳島)
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] 化合物アレイを用いた抗がん剤スクリーニング法の開発2009
- Author(s)
  清水史郎
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島(徳島)
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] A small molecule inhibitor of Pirin that suppresses tumor cell migration2009
- Author(s)
  清水史郎
- Organizer
  2009 AACR-NCI-EORTC International Conference
- Place of Presentation
  Boston, U.S.A
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] Discovery of small-molecule inhibitors by chemical array2009
- Author(s)
  清水史郎, 他
- Organizer
  RIKEN 2009 Joint retreat
- Place of Presentation
  熱海ニューフジヤホテル(熱海)
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] Synthesis and Biological Evaluation of 6, 6-Spiroketal Natural Products2008
- Author(s)
  Shimizu Takeshi
- Organizer
  4th RIKEN Symposium on Chemical Biology
- Place of Presentation
  Atami, Sizuoka
- Year and Date
  2008-02-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590027
[Presentation] 6,6-スピロケタール天然物の合成と活性2008
- Author(s)
  清水猛
- Organizer
  第4回ケミカルバイオロジーシンポジウム
- Place of Presentation
  熱海
- Year and Date
  2008-02-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590027
[Presentation] ヒト線維肉腫細胞株におけるヘパラナーゼ結合タンパク質の探索と同定2008
- Author(s)
  清水史郎, 他
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] ヘパラナーゼ結合タンパク質の探索と活性化機構の解析2008
- Author(s)
  清水史郎, 他
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  学術総合センター(東京)
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] Synthesis and Biological Evaluation of 6, 6-Spiroketal Natural Products2007
- Author(s)
  Shimizu Takeshi
- Organizer
  49th Symposium on the Chemistry of Natural Products
- Place of Presentation
  Sapporo, Hokkaido
- Year and Date
  2007-09-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590027
[Presentation] Synthetic Studies of Reveromycin A : Novel Preparation of the Succinates of Tertiary Alcohols2007
- Author(s)
  Takeshi Shimizu
- Organizer
  21st International Congress for Heterocyclic Chemistry
- Place of Presentation
  Australia, Sydney
- Year and Date
  2007-07-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590027
[Presentation] ヘパラナーゼに存在するシステイン残基の修飾とその役割解析2007
- Author(s)
  清水史郎, 他
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2007-07-05
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] Synthetic Studies of Reveromycin A : Novel Preparation of the Succinates of Tertiary Alcohols2007
- Author(s)
  Shimizu Takeshi
- Organizer
  21st International Congress for Heterocyclic Chemistry
- Place of Presentation
  Sydney, Australia
- Year and Date
  2007-07-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590027
[Presentation] Synthetic Studies of Reveromycin A:Novel Preparation of the Succinates of Tertiary Alcohols2007
- Author(s)
  Takeshi Shimizu
- Organizer
  21^<st> International Congress for Heterocyclic Chemistry
- Place of Presentation
  Australia,Sydney
- Year and Date
  2007-07-19
- Data Source
  KAKENHI-PROJECT-18590027
[Presentation] A novel chemical microarray platform for searching anticancer drugs2007
- Author(s)
  清水史郎, 他
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] 6,6-スピロケタール天然物の合成と活性2007
- Author(s)
  清水猛
- Organizer
  第49回天然有機化合物討論会
- Place of Presentation
  札幌
- Year and Date
  2007-09-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590027

1. USUI Takeo (60281648)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. YOSHIDA Minoru (80191617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. OSADA Hiroyuki (80160836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SAITO Akiko (40415162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHIRO Yoshitsugu (70183051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAKEYA Hideaki (00270596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HAYASHI Yujiro (00198863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOJIMA Soichi (10202061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKAHASHI Shunji (30311608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OKUMURA Hideo (90377903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SUZUKI Kunio (60100054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. IKE Fumio (40183157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SAKAMOTO Yasuharu (60280723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MACHIDA Kiyotaka (30332266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 臼井健朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMIZU Takeshi 清水 猛

Research Projects

Research Products

Co-Researchers

Synthesis and Biological Evaluation of Spiroketal DerivativesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical proteomics to reveal interaction between chemicals and proteins at angstrom level

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Synthesis and Biological Evaluation of Antifungal Antibiotics, Spirofungin A and BPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies for Structure-Activities Relationships of Reveromycin A : An Inhibitor of Eukaryotic Cell GrowthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthetic Studies of Reveromycin A : An Inhibitor of Eukaryotic Cell GrowthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEVELOPMENT OF USEFUL REACTIONS USING THE NOVEL LEAVING GROUP, MONOCHLATEPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Antihyperlipidemic and anti-obesity effects of cholesteone

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 化合物アレイを用いた抗がん剤探索系「がん分子標的治療研究 実践マニュアル(日本がん分子標的治療学会 編)」2009

Author(s)

Total Pages

Publisher

Data Source

[Book] がんの分子標的治療 第III部 25「浸潤と転移-1 タンパク質分解酵素と糖分解酵素」2008

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] 分子細胞学的解析2009

Author(s)

Journal Title

Data Source

[Journal Article] 6, 6-スピロケタール天然物reveromycin A, Bおよびspirofungin A, Bの合成と活性2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Synthesis and Biological Activities of Reveromycin A and Spirofungin A Derivatives2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis and Biological Activities of Reveromycin A and Spirofungin A Derivatives2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] A new route for the preparation of succinates2008

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis and biological activities of reveromycin A and spirofungin A derivatives2008

Author(s)

SHIMIZU Takeshi 清水猛

[Book] 化合物アレイを用いた抗がん剤探索系「がん分子標的治療研究実践マニュアル(日本がん分子標的治療学会編)」2009

[Book] がんの分子標的治療第III部 25「浸潤と転移-1 タンパク質分解酵素と糖分解酵素」2008