ISHIKAWA Naohisa 石川直久

Researcher Number	80109321
Other IDs
Affiliation (based on the past Project Information) *help	2013: 愛知医科大学, 医学部, 教授 1997 – 2006: 愛知医科大学, 医学部, 教授 1998 – 1999: 愛知医科大学, 教授 1986 – 1988: 名古屋大学, 医学部, 助教授 1986: 名大, 医学部, 助教授
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / General pharmacology Except Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies / 応用薬理学・医療系薬学 / General pharmacology / 麻酔学 / Applied pharmacology
Keywords	Principal Investigator peptide YY / neuropeptide Y / pulmonary circulation lung innervation pulmonary edema / bronchopulmonary anastomotic blood flow / sympathetic nervous system / 圧受容反射 / フィブリン / 肺内毛細血管圧 / 肺水腫 / セロトニン … More / 気管支静脈 / 星状神径節 / α-ブロッカー / サブスタンスP / フィブリン肺水腫 / 交感神経系 / 気管支-肺血流量 / 肺循環系 / pulmonary circulation / vascular endothelial cell / cDNA library / lung vascular permeability / cloning / neuropeptide Y Y3-receptor / neuropeptide Y Y_3受容体 / 肺循環 / 血管内皮細胞 / cDNAライブラリー / 肺血管透過性 / クローニング / neuropeptide Y Y3受容体 … More Except Principal Investigator 神経原性肺水腫 / neuropeptide Y / ^<31>P-NMR / neurogenic pulmonary edema / ARDS / MPTP / apoptosis / 迷走神経 / ESR / nitric oxide / 肺水腫 / LVDP / ischemia-reperfused injury / guinea-pig Langendorff hearts / eNOS / 血管透過性亢進 / ML-9 / Abelson tyrosine kinase / Tunel / vagal nerve / pulmonary vascular permeability / NO / Na-H exchange inhibitor / Myocardial mitochondria / EPR / Fluorometry / Ischemia-reperfusion injury / pulmonary edema / vascular permeability / 血管透過性 / ミオシン軽鎖キナーゼ / 肺血管透過性 / 神経原生肺水腫 / 麻酔薬 / NOS / Myosin Light Chain Kinase Inhibitor / Aggregation and Secretion Response of Platelets / Myosin Light Chain Kinase Vascular Smooth Muscle Contraction / Myosin Light Chain Phosphorylation / Intracellular Calcium Requlation / 血小板放出反応 / 平滑筋収縮反応 / カルシウム依存性リン酸化反応 / 分子薬理学 / MLー9 / ミオシン軽鎖キナーゼ阻害剤 / 放出反応 / 血小板凝集 / 血管平滑筋収縮 / ミオシン軽鎖リン酸化反応 / 細胞内カルシウム調節機構 / Sciatic nerves / Fibroblasts / Neurite outgrowth / Dorsal root ganglia / Schwann cells / Carbon Dioxide Concentration / Cardiopulmonary Nerve / Vagus Nerve / Anesthetic Depth / Neurogenic Pulmonary Edema / Pulmonary Edema / PEEP / 人工呼吸 / セロトニン,ケタンセリン / 気管支循環 / 星状神経節 / セロトニン / ヒスタミン / 肺肺潅流標本 / 気管支動脈循環 / 肺血管外水分量 / 二酸化炭素濃度 / 心肺神経 / 麻酔深度 / 中枢性肺水腫 / anesthetic agent / cell culture / pulmonary endothelial cell / ALI / 部分肺還流標本 / Dibutyryl cAMP / 細胞培養 / 肺血管透過性亢進 / 肺血管内皮細胞 / NO-releasing drug. / eNOS. / ESR. / Fluorometry. / Ischemia-reperfusion injury. / NO放出化合物 / Ischemia-reperfused injury / NPYY_3 receptor / vascular endothelial cell proliferation / vascular regeneration / actin polymeration / Ab1 / 低酸素状態 / 細胞増殖 / 血管内皮細胞 / 低酸素暴露 / 大動脈内皮細胞 / ニューロペプタイドY / NPY Ya-受容体 / Abelson tyrosine Kinase / NPY Y_3-受容体 / 内皮細胞増殖 / 血管新生 / Tuner / <31>^P-NMR / free radical / Langendorff hearts / guinea-pig / neuropeptide Y-Y3 receptor / NMDA receptor / fibrin induced pulmonary edema / bNOS / 弧束核 / 迷走神経切断 / neuropeptide Y-Y3受容体 / neuropeptide Y(NPY) / NMDA受容体 / 一酸化窒素(NO) / ラットフィブリン肺水腫 / fibrin-induced pulmonary edema / vagus nerve / フィブリン肺水腫 / No-releasing drug / NO・ラジカル / ミトコンドリア / fluorometry / NMR / 左室内圧(LVDP) / 虚血再灌流 / c(e)NOS / NO-releasing drug / sympathetic nervous system / central nervous system / lung / 肺循環 / neuropepetides / neropeptide Y / 神経伝達物質 / 交感神経系 / 中枢神経系 / 肺 / カルモデュリン / カルシウム結合蛋白質 / サイロキシン / ＡＲＤＳ / 肺移植 / 脳死 / 神経ペプチドY / 肺動脈血管内皮細胞 / 脳死肺移植 / 神経ペプチドＹ / 肺動脈内皮細胞 / 細胞透過性 Less

Clarification of the pathophysiology of brain death-associated lung function impairment and research on the precaution and remedy
- Principal Investigator
  
  NISHIWAKI KIMITOSHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Nagoya University
Mechanisms of increased vascular permeability associated with sympathetic excitability and the development of treatment strategy of ARDS.
- Principal Investigator
  
  SHIMADA Yasuhiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Nagoya University
Cardiomyocyte apoptosis related with mitochondrial PTP in ischemia-reperfusion injury and the development of new cardiac drug.
- Principal Investigator
  
  HOTTA Yoshihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Aichi Medical University
Mechanism of permeability increase induced by neuropeptide Y in neurogenic pulmonary edema
- Principal Investigator
  
  NISHIWAKI Kimitoshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Nagoya University
Cardiomyocyte apoptosis induced in ischemia-reperfusion Langendorff preparation and the development of new cardiac drug.
- Principal Investigator
  
  HOTTA Yoshihiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Aichi Medical University School of Medicine
Study on pathophysiology of central nervous system in neurogenic pulmonary edema (role of vagal nerve and nitric oxide)
- Principal Investigator
  
  NISHIWAKI Kimitoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Nagoya University
Study on the Neural Network relating to Pulmonary Vascular Permeability and Cloning of its Receptor
- Principal Investigator
  
  SHIMADA Yasuhiro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Nagoya University
DETERMINATION OF DNA SEQUENCE OF NEUROPEPTIDE Y Y3-RECEPTORPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Naohisa
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Aichi Medical University
神経原性肺水腫における一酸化窒素(NO)の役割
- Principal Investigator
  
  山下明子
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Nagoya University
Maintenance for the positive inotropic effect in ischemic myocardial mitochondria and the development of new cardiac drug.
- Principal Investigator
  
  HOTTA Yoshihiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Aichi Medical University School of Medicine
Study of the mechanism of lung vascular permeability in pulmonary edema
- Principal Investigator
  
  SHIMADA Yasuhiro
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  NAGOYA UNIVERSITY
癌細胞のカルモデュリン依存性蛋白リン酸化反応に関する分子薬理学的研究
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
Molecular pharmacological approarches of intracellular calcium regulatory mechanisms
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Nagoya University School of Medicine
Mechanism and the Effects of Anesthetics and Anesthetic Depth on the Development of Neurogenic Pulmonary Edema.
- Principal Investigator
  
  SHIMADA Yasuhiro (MIYAMOTO Yoshihiro)
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  麻酔学
- Research Institution
  Nagoya University School of Medicine
Role of central nervous sytem in the changes in pulmonary hemodynamics and vascular permeabilityPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Naohisa
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Department of Pharmacol., Nagoya University School of Medicine

All 2006 2005 2004 Other

All Journal Article Book

[Book] SIRSの病態と治療 I ALI/ARDS 神経原生肺水腫(監修:相川直樹、編集:藤島清太郎)2004
- Author(s)
  西脇公俊, 石川直久, 島田康弘
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-16591532
[Book] シンプル薬理学第3版2004
- Author(s)
  石川直久
- Total Pages
  332
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-16390448
[Journal Article] Different effects of optical isomers of the 5-HT_<1A> receptor antagonist pyrapyridolol against postischemic guinea-pig myocardial dysfunction and apoptosis through the mitochondrial permeability transition pore.2006
- Author(s)
  Lei Huang, Yoshihiro Hotta, Kunihiro Miyazeki, Naohisa Ishikawa, Yasuyoshi Miki, Yumi Sugimoto, Jun Yamada, Akinobu Nakano, Kimitoshi Nishiwaki, Yasuhiro Shimada.
- Journal Title
  
  Eur J Pharmacol 534
  
  Pages: 165-177
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Nicorandil inhibits Ca^<++> overload of an isolated porcine myocardial mitochondria through mitochondrial permeability transition pore.2005
- Author(s)
  Yasushi Wakida, Yoshihiro Hotta, Michio Yajima, Naohisa Ishikawa, Motoyuki Fukuda, Takayuki Itoh.
- Journal Title
  
  Therapeutic Res 26
  
  Pages: 1-5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal cord.2004
- Author(s)
  Naohisa Ishikawa
- Journal Title
  
  Peptides 25
  
  Pages: 1909-1916
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390448
[Journal Article] Differences in the effects of Na^+-H^+ exchange inhibitors on cardiac function and apoptosis in guinea-pig ischemia-reperfused hearts.2004
- Author(s)
  Hotta Y, Nishimaki H, Takeo T, Itoh G, Yajima M, Otsuka-Murakami H, Ishikawa N, Kawai N, Huang L, Yamada K, Yamamoto S, Matsui K, Ohashi N.
- Journal Title
  
  Eur J Pharmacol 503
  
  Pages: 109-122
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal coad.2004
- Author(s)
  ISHIKAWA Naohisa, FENG Gua-Gang, ITO Yoshitake, HOTTA Yoshihiro, WAKIDA Yasushi, MURAKAMI Hidetsugu, YAJIMA Michio, ISHIKAWA Atuko, YOKOCHI Takashi.
- Journal Title
  
  Peptide 251
  
  Pages: 909-1916
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] A role for L-glutamete ionotropic receptors in the developments of rat neurogenic pulmonary edema.2004
- Author(s)
  KONDO H, FENG GG, NISHIWAKI K, ISHIKAWA N, 他
- Journal Title
  
  Eur.J.Pharmacol. 499(3)
  
  Pages: 257-263
- Data Source
  KAKENHI-PROJECT-16591532
[Journal Article] Neuropeptide Y enhances permeability across a rat aortic endothelial cell monolaver.2004
- Author(s)
  NAN YS, FENG GG, HOTTA Y, NISHIWAKI K, SHIMADA Y, ISHIKAWA N 他
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol. 286(3)
- Data Source
  KAKENHI-PROJECT-16591532
[Journal Article] A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal cord2004
- Author(s)
  Ishikawa Naohisa
- Journal Title
  
  Peptides 25
  
  Pages: 1909-1916
- Data Source
  KAKENHI-PROJECT-16390448
[Journal Article] A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal coad2004
- Author(s)
  ISHIKAWA Naohisa et al.
- Journal Title
  
  Peptide 251
  
  Pages: 909-1916
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Protective effects of EGCg or GCg, a green tea catechin epimer, against postischemic myocardial dysfunction in guinea pig hearts.
- Author(s)
  Masaya Hirai, Lei Huang, Yoshihiro Hotta, Naohisa Ishikawa, Yasushi Wakida, Yoshitaka Fukuzawa, Akinobu Nakano.
- Journal Title
  
  Life science. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443
[Journal Article] Positive inotropic effect of purified green tea catechin derivative in guinea pig hearts : the measurements of cellular Ca^<2+> and NO release.
- Author(s)
  Yoshihiro Hotta, Lei Huang, Tatsuya Muto, Michio Yajima, Kunihiro Miyazeki, Naohisa Ishikawa, Yoshitaka Fukuzawa, Yasushi Wakida, Hiromi Tushima, Hiroaki Ando, Tunemasa Nonogaki.
- Journal Title
  
  Eur J Phannacol. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590443

1. SHIMADA Yasuhiro (50028669)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. NISHIWAKI KIMITOSHI (10189326)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. HOTTA Yoshihiro (40109757)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. MURAKAMI Hidetsugu (80131225)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. YAJIMA Michio (50065596)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
6. KAWAI Norio (50095535)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. HIDAKA Hiroyoshi (80100171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SHIGEI Tatsuro (60013786)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. FUJIWARA Yoshihiro (70238640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KIMURA Tomomasa (50161568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ITO Gen (10022823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FURUTA Tatsuji (60135382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KAINUMA Motoshi (90135335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKA Michiko (10093139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TANAKA Toshio (00135443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山下明子 (50293709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 佐藤光晴 (10235343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 竹尾友宏 (90351105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ISHIKAWA Naohisa 石川 直久

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DETERMINATION OF DNA SEQUENCE OF NEUROPEPTIDE Y Y3-RECEPTORPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of central nervous sytem in the changes in pulmonary hemodynamics and vascular permeabilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ISHIKAWA Naohisa 石川直久