Tanaka Toshio 田中利男

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TANAKA Toshio 田中利男

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Researcher Number	00135443
Other IDs
Affiliation (Current)	2023: 三重大学, 医学系研究科, 産学官連携講座大学教員
Affiliation (based on the past Project Information) *help	2021 – 2023: 三重大学, 医学系研究科, 産学官連携講座大学教員 2018: 三重大学, 医学系研究科, 産学官連携講座大学教員 2016 – 2017: 三重大学, 医学系研究科, 教授 2011 – 2016: 三重大学, 医学(系)研究科(研究院), 教授 2014: 三重大学, 大学院医学系研究科, 教授 … More 2012: 三重大学, 大学院・医学系研究科, 教授 1988 – 2004: Mie University School of Medicine, Professor, 医学部, 教授 1986 – 1987: 三重大学, 医学部, 講師 1986: 三重大, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / General pharmacology / Biological Sciences / General pharmacology / Applied pharmacology / Basic Section 48030:Pharmacology-related Except Principal Investigator General pharmacology / 物質生物化学 / Digestive surgery / Biological pharmacy … More / Risk sciences of radiation/Chemicals / Hygiene and public health / 分子遺伝学・分子生理学 / Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies / General pharmacology / Pediatrics / Basic Section 56030:Urology-related Less
Keywords	Principal Investigator S100C / カルシウム結合蛋白質 / 遺伝子発現 / カルシウム / 脳血管攣縮 / カルモデュリン / トランスクリプトーム / S100L / カルポニン / S100蛋白質 … More / 心筋 / 低酸素 / 平滑筋 / カルシウムイオン / アクチン / 分化制御 / 分子生物学 / S100蛋白質ファミリー / cDNAクローニング / ラット / プロテインキナーゼ / カルシウム感受性 / EFハンド / トランスクリプトーム解析 / Heme Oxygenase-1 / 脳血管障害 / cerebral vasospasm / プロテオーム / S100 protein / Calmodulin / PAF / 遺伝子発現変化 / 癌細胞 / Calcium-binding Proteins / Differential Gene Expression / Tumor Cell / mRNA differential display / in situ hybridization / caltractin / 分子薬理学 / gene expression / actin / HSP72 / ゼブラフィッシュ / Sー100 / がん細胞 / メラノーマ / cAMP / cAMP依存性蛋白質リン酸化酵素 / Cキナ-ゼ / cDNAクロ-ニング / プロテインキナ-ゼC / 蛋白質リン酸化反応 / トロポミオシン / 転写因子 / ラフト / リン酸化部位 / 活性ペプチド / 血管平滑筋 / 収縮機構 / カルシウムセンシタイザー / セリン・スレオニンキナーゼ / チロシンキナーゼ / プロテインキナーゼ阻害薬 / マイクロアレイ法 / ディファレンシャル・ディスプレイ法 / ESTデータベース / in silico cDNAクローニング / 悪性腫瘍 / カルシウム結合蛋白 / ハイポキシアレスポンスエレメント / 薬理ゲノム科学 / 疾患関連遺伝子 / 治療関連遺伝子 / 創薬ターゲット / 脳底動脈 / ゲノム創薬科学 / DNAチップ / 脳虚血 / CO / cGMP / hemin / basilar artery / rat / antisense oligodeoxynucleotide / heat shock protein 72 / heat shock protein 27 / DNAマイクロアレイ / 遺伝子クラスター / ゲノム創薬 / マイクロアレイ / ヘムオキシゲナーゼ / 薬理プロテオミクス / 薬理プロテオームデータベース / 遅発性脳血管攣縮 / 病態応答遺伝子クラスター / 病態応答発現蛋白質クラスター / 治療薬ターゲット分子 / 創薬・ゲノム薬理学 / 肥満モデル / オミックス / 治療遺伝子 / 疾患モデル / Zebrafish / cance / xenotransplantation / immunological tolerance / RNA-seq / システムズ薬理学 / 悪性腫瘍免疫寛容 / ヒト慢性骨髄性白血病細胞 / ヒト前立腺癌細胞 / 免疫機構 / 異種細胞免疫寛容機構 / 免疫寛容関連遺伝子 / 阻害薬 / 細胞骨格 / 腎臓 / 心臓 / カルシウム情報伝達 / アフィニティークロマドグラフィー / アフィニティ-クロマトグラフィ- / S100蛋白質ファミリ- / Calcium ion / Calcium binding protein / Inhibitor / Cytoskeleton / Kidney / Beart / 白血球 / 走化性 / 好酸球 / 細胞内情報伝達 / 白血球活性化因子 / Leucocyte / Eosinophil / Chemotaxis / Ca^<2+>-binding protein / Signal transduction / プロプラノロール / 心疾患 / 好酸球走化性因子 / Proplanolol / Heart Disease / Eosinophilic Chemotactic Factor / 遺伝子治療 / ヒト疾患病態 / 乳癌 / two-hybrid system / 薬物治療学 / 螢光ディファレンシャル・ディスプレイ法 / 病態遺伝子 / 薬物治療遺伝子 / キャピラリー電気泳動 / マルチメディアデータベース / gene therapy / human clinical pathology / breast carcinoma / 虚血性心疾患 / genomic gene / Ischemic Heart Disease / Hypoxia / Genomic Gene / S100ファミリー / 病態 / アクチン結合タンパク質 / 種々の病態 / S100 Protein Family / Disease / Gene Expression / calcium / Actin Binding Proteins / Mg-ATPase / Mg-ATPase活性 / 血管収縮 / calcium sensitization / Mg2+-ATPase / hypoxia / 薬理ゲノミクス / 甲状腺疾患 / バセドウ病 / PDE / スプライシング / クローニング / Pharmacogenomics / thyroid disease / Basedow's disease / phosphodiesterase / splicing / 血管リモデリング / ストレス蛋白質 / 肺高血圧症 / プロテオームデータベース / 低酵素 / タウリン / クモ膜下出血 / くも膜下出血 / vascular remodeling / proteome / stress protein / pulmonary hypertension / proteome database / 細胞内カルシウム受容蛋白質 / プロテインキナーゼC / カルシウム依存性プロテアーゼ / カルパイン / ミオシン軽鎖リン酸化酵素 / カルモデュリン阻害剤 / カルシウムチャンネルブロッカー / トロポニンC / パルブアルブミン / カルモデュリン依存性酵素 / Intracellular Calcium-Receptine Protein / Molecular Pharmacology / Protein Kinase C / Calcium-dependent Protease / Calpain / Myosin Light Chain Kinase / ヒトがん幹細胞阻害薬 / ZM-B708 / 悪性腫瘍治療抵抗性 / ヒトがん幹細胞治療薬 / 免疫不全マウス / 蛍光試薬 / がん幹細胞選択性 / ハイスループットスクリーニングシステム / 心毒性防御遺伝子 / 心毒性機構解析 / がん分子標的薬 / ①ハイスループットスクリーニングシステム / ②心毒性防御遺伝子 / ③心毒性機構解析 / ④がん分子標的薬 / ⑤ゼブラフィッシュ … More Except Principal Investigator ゼブラフィッシュ / Cキナーゼ / ミオシン軽鎖キナーゼ / ML-9 / DNAマイクロアレイ / 炎症 / 平滑筋 / 低酸素 / 肺高血圧 / cDNAマイクロアレイ / Myosin light chain kinase / 胆管癌 / 遺伝子発現 / 螢光ディファレンシャル・ディスプレイ / 癌抑制遺伝子 / 癌遺伝子 / 創薬 / 機能ゲノム科学 / 遺伝子発現プロファイル / 遺伝子 / マイクロアレイ / 放射線 / 発達神経毒性 / 行動解析 / 治療薬 / スクリーニング / 放射線影響評価 / 蛍光生体イメージング / 肥満 / 脂質異常症 / バイオインフォマティクス / 薬理 / ゲノム / 環境ストレス / ナノ粒子 / カーボンナノチューブ / 動脈硬化 / ナノ素材 / リスクアセスメント / 環境毒性学 / 衛生学 / 環境衛生 / 安全性 / 心血管毒性 / チロシンキナーゼ / 細胞増殖 / 発癌プロモーター / CDNAクローン / モノクローナル抗体 / 免疫組織化学 / モーター蛋白質 / アクチン / ミオシン / カルシウム / 制御機能 / モ-ティリティー・アッセイ / 核磁気共鳴 / 遠心顕微鏡 / モーティリティー・アッセイ / アイチン / アクトミオシン / カルポニン / カルデスモン / シャジク藻 / 原形質流動 / チュブリン / ダイニン / ATP / Motor protein / Actin / Myosin / Calcium / Regulation / Motility Assay / NMR / Centrifuge Microscope / 肺高気圧 / 低酵素 / hypoxia / pulmonary hypertension / DNA microarray / 肺高血圧症 / Pulmonary Hypertension / Hypoxia / DNA Microarray / 細胞内カルシウム調節機構 / ミオシン軽鎖リン酸化反応 / 血管平滑筋収縮 / 血小板凝集 / 放出反応 / ミオシン軽鎖キナーゼ阻害剤 / MLー9 / 分子薬理学 / カルシウム依存性リン酸化反応 / 平滑筋収縮反応 / 血小板放出反応 / Intracellular Calcium Requlation / Myosin Light Chain Phosphorylation / Myosin Light Chain Kinase Vascular Smooth Muscle Contraction / Aggregation and Secretion Response of Platelets / Myosin Light Chain Kinase Inhibitor / 血小板 / 蛋白質リン酸化反応 / ミオシン軽鎖リン酸化酵素 / Platet / protein phosphorylation / プロテインキナーゼ阻害剤 / アフィニティークロマトグラフ / Aキナーゼ / サイロキシン / Thyroxine / Affinity chromatography / Protein kinase C / 肺動脈性肺高血圧 / 治療 / 病態 / 血管平滑筋 / 動物モデル / エンドセリン / 血管生物学 / 肥大型心筋症 / トランスクリプトーム / オミクス解析 / データベース / ゲノム編集 / 酸化ストレス / ユビキチン・プロテアソーム系 / 公共データベース / オミックス解析 / 心血管・血液 / 膀胱癌 / 異種移植モデル / 薬物療法 / 膀胱がん / 薬剤効果判定 Less

がん分子標的薬のOncocardiology研究Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Mie University
Clinical application of patient-derived xenograft zebrafish model of bladder cancer for evaluating drug efficacy and discovering new seeds of treatment
- Principal Investigator
  
  井上貴博
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Mie University
Systems pharmacology for discovering novel genes related to hypertrophic cardiomyopathy
- Principal Investigator
  
  Nishimura Yuhei
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
New treatment for pulmonary arterial hypertension targeting on inflammation-dedifferentiation pathway
- Principal Investigator
  
  Mitani Yoshihide
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
in vivo Mechanisms of Novel Selective Fluorescent Leukemia Stem Cell InhibitorPrincipal Investigator
- Principal Investigator
  
  Tanaka Toshio
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
Investigation on the effects of environmental stress on the cardiovascular system
- Principal Investigator
  
  ICHIHARA Sahoko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene and public health
- Research Institution
  Mie University
Novel immunological tolerance in zebrafish of human cancer cell xenotransplants and cancer immunotherapy mechanismsPrincipal Investigator
- Principal Investigator
  
  TANAKA TOSHIO
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
Development of zebrafish-based assay to detect developmental neurotoxicity of irradiation and to identify protectants against the neurotoxicity
- Principal Investigator
  
  NISHIMURA Yuhei
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Mie University
エリオシトリンによるメタボリックシンドローム改善作用の網羅的メカニズム解析
- Principal Investigator
  
  島田康人
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
Identification of novel drug targets with Omics-based mechanismsfor obesity treatmentPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
薬理プロテオミクスの創成と展開Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Mie University
脳血管障害におけるゲノム創薬ターゲットの作用機構解析Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Mie University
Transcriptome analysis of hypoxia induced pulmonary hypertension
- Principal Investigator
  
  AMANO Homare
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Mie University
脳血管障害におけるゲノム創薬ターゲット探索法の開発Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Mie University
トランスクリプトーム解析とファルマインフォマティクスの統合ゲノム薬理学Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Mie University
Pharmacoproteomic mechanisms in stress protein expression inductionPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
脳血管障害におけるゲノム創薬科学解析法の開発Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Mie University
脳血管攣縮における一酸化炭素(CO)/cGMPシグナリングの治療的役割Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Mie University
Pharmacogenomics of thyroid disease in molecular target discoveryPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Mie University
Transcriptome analysis of hypoxia-induced pulmonary hypertension
- Principal Investigator
  
  AMANO Homare
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Mie University
トランスクリプトーム解析によるゲノム創薬科学Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Mie University
創薬、医療を目的とした「機能ゲノム科学」の戦略的手法の樹立
- Principal Investigator
  
  内田和彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Tsukuba
シグナル伝達の細胞内局在に関する薬理ゲノム科学的解析Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Mie University
プロテインキナーゼ阻害薬による遺伝子発現制御機構Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Mie University
新しいカルシウムシグナリングの分子機構に関する薬理学的研究Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
Genome pharmacology on novel calcium signaling in diseasesPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Mie University
Clinical Therapeutic Research of Calcium SensitizationPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Mie University
新しいプロティンキナーゼ基質分子のシグナル伝達機構に関する研究Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Mie University
胆管癌の遺伝子発現解析と臨床への応用
- Principal Investigator
  
  林正晃
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Mie University
Molecular cell pharmacology on calcium signaling in diseasesPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Mie University
Molecular cell pharmacology on Novel calcium signalingPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Mie University
Novel Molecular Pharmacological Strategy in Clinical Therapeutic ResearchPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Mie University
心筋細胞の分化機構に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Mie University
心筋細胞の分化制御機構に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Mie University
Molecular Pharmacology of Leucocyte ActivationPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
新しいS100蛋白質ファミリ-の癌細胞における発現とその調節機構Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Mie University
カルポニンを介する平滑筋収縮の調節機構Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Mie University
Role of motor proteins in cell motility
- Principal Investigator
  
  KOHAMA Kazuhiro
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  分子遺伝学・分子生理学
- Research Institution
  Gunma University School of Medicine
Molecular Pharmacology of Calcium Signal TransductionPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University(School of Medicine)
がん細胞における新しいカルシウム結合蛋白質の検索とその機能発現機構の解析Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Mie University
CAMP依存性蛋白質リン酸化反応によるカルシウム情報伝達の制御機構Principal Investigator
- Principal Investigator
  
  田中利男
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Mie University
Cキナーゼ活性の新規化合物による分子制御機構の細胞生物学的解析
- Principal Investigator
  
  日高弘義
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
Molecular pharmacological approarches of intracellular calcium regulatory mechanisms
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Nagoya University School of Medicine
Molcular control of platelets function by protein kinases
- Principal Investigator
  
  NAKA Michiko
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Mie University
Development of analytical method of molecular function in protein kinases by using newly synthesized protein kinase inhibitor - affinity chromatography
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  物質生物化学
- Research Institution
  Nagoya University School of Medicine
  Mie University
発癌機構におけるCキナーゼ及びチロシンキナーゼによる蛋白質リン酸化反応の意義
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Mie University
Molecular Pharmacology of Intracellular Calcium-Receptive Protein SignalingPrincipal Investigator
- Principal Investigator
  
  TANAKA Toshio
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University

All 2021 2018 2017 2016 2015 2014 2013 2012 2011 2004 2003 2002 Other

All Journal Article Presentation Book Patent

[Book] Cancer Cell Signaling Methods and Protocols2014
- Author(s)
  Yasuhito Shimada, Yuhei Nishimura, and Toshio Tanaka
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25670127
[Book] ゲノム研究実験ハンドブック(辻本豪三、田中利男編)2004
- Author(s)
  田中利男
- Total Pages
  6
- Publisher
  羊土社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207003
[Book] ゲノム研究実験ハンドブック(辻本豪三, 田中利男編)2004
- Author(s)
  田中利男
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16659137
[Journal Article] Prognostic Effect of Preoperative Psoas Muscle Hounsfield Unit at Radical Cystectomy for Bladder Cancer2021
- Author(s)
  Sugino Yusuke、Sasaki Takeshi、Kato Manabu、Masui Satoru、Nishikawa Kouhei、Okamoto Takashi、Kajiwara Shinya、Shibahara Takuji、Onishi Takehisa、Tanaka Shiori、Kanda Hideki、Matsuura Hiroshi、Inoue Takahiro
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 22 Pages: 5629-5629
- DOI
  10.3390/cancers13225629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03066
[Journal Article] Tetraploidy in cancer and its possible link to aging.2018
- Author(s)
  Tanaka K, Goto H, Nishimura Y, Kasahara K, Mizoguchi A, Inagaki M.
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 9 Pages: 2632-2640
- DOI
  10.1111/cas.13717
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08269, KAKENHI-PROJECT-15H02398, KAKENHI-PROJECT-18H02434, KAKENHI-PROJECT-16K08547, KAKENHI-PUBLICLY-18H04896
[Journal Article] EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase2018
- Author(s)
  Kasahara K, Aoki H, Kiyono T, Wang S, Kagiwada H, Yuge M, Tanaka T, Nishimura Y, Mizoguchi A, Goshima N, Inagaki M
- Journal Title
  
  Nat Commun
  
  Volume: 9 Issue: 1 Pages: 758-758
- DOI
  10.1038/s41467-018-03117-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08269, KAKENHI-PLANNED-24113005, KAKENHI-PROJECT-15H02398, KAKENHI-PROJECT-16K08547
[Journal Article] New photic stimulating system with white light-emitting diodes to elicit electroretinograms from zebrafish larvae2017
- Author(s)
  Hisashi Matsubara, Yoshitsugu Matsui, Ryohei Miyata, Yuhei Nishimura, Tetsuro Yamamoto, Toshio Tanaka, Mineo Kondo
- Journal Title
  
  Documenta Ophthalmologica
  
  Volume: 135 Issue: 2 Pages: 147-154
- DOI
  10.1007/s10633-017-9602-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08547, KAKENHI-PROJECT-17K19721
[Journal Article] Chemokines protect vascular smooth muscle cells from cell death induced by cyclic mechanical stretch2017
- Author(s)
  Jing Zhao, Yuhei Nishimura, Akihiko Kimura, Kentaro Ozawa, Toshikazu Kondo, Toshio Tanaka, Masanori Yoshizumi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 16128-16128
- DOI
  10.1038/s41598-017-15867-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08547, KAKENHI-PROJECT-26293163, KAKENHI-PROJECT-26461277
[Journal Article] Titanium dioxide particle type and concentration influence the inflammatory response in Caco-2 cells2016
- Author(s)
  Tada-Oikawa S, Ichihara G, Fukatsu H, Shimanuki Y, Tanaka N, Suzuki Y, Murakami M, Izuoka K, Chang J, Wu W, Yamada Y, Ichihara S
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 17 Issue: 4 Pages: 576-576
- DOI
  10.3390/ijms17040576
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15236, KAKENHI-PROJECT-26293149, KAKENHI-PROJECT-25460798, KAKENHI-PROJECT-15H04772, KAKENHI-PROJECT-16H02965, KAKENHI-PROJECT-26305023, KAKENHI-PROJECT-26670329
[Journal Article] Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy2016
- Author(s)
  Shota Sasagawa, Yuhei Nishimura, Shiko Okabe, Soichiro Murakami, Yoshifumi Ashikawa, Mizuki Yuge, Koki Kawaguchi, Reiko Kawase, Ryuji Okamoto, Masaaki Ito and Toshio Tanaka
- Journal Title
  
  Frontiers in pharmacology
  
  Volume: 7 Pages: 162-162
- DOI
  10.3389/fphar.2016.00162
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08547
[Journal Article] DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina2016
- Author(s)
  Shota Sasagawa, Yuhei Nishimura, Tetsuo Kon, Yukiko Yamanaka, Soichiro Murakami, Yoshifumi Ashikawa, Mizuki Yuge, Shiko Okabe, Koki Kawaguchi, Reiko Kawase and Toshio Tanaka
- Journal Title
  
  Front. Pharmacol.
  
  Volume: 7
- DOI
  10.3389/fphar.2016.00057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15051
[Journal Article] Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish.2016
- Author(s)
  Zhang B, Shimada Y, Hirota T, Ariyoshi M, Kuroyanagi J, Nishimura Y, Tanaka T.
- Journal Title
  
  Transl Res.
  
  Volume: 170 Pages: 89-98
- DOI
  10.1016/j.trsl.2015.12.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15051
[Journal Article] Using zebrafish in systems toxicology for developmental toxicity testing.2016
- Author(s)
  Nishimura Y, Inoue A, Sasagawa S, Koiwa J, Kawaguchi K, Kawase R, Maruyama T, Kim S, Tanaka T.
- Journal Title
  
  Congenit Anom (Kyoto).
  
  Volume: 56 Issue: 1 Pages: 18-27
- DOI
  10.1111/cga.12142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15051
[Journal Article] In Vivo Detection of Mitochondrial Dysfunction Induced by Clinical Drugs and Disease-Associated Genes Using a Novel Dye ZMJ214 in Zebrafish.2016
- Author(s)
  Sasagawa S, Nishimura Y, Koiwa J, Nomoto T, Shintou T, Murakami S, Yuge M, Kawaguchi K, Kawase R, Miyazaki T, Tanaka T.
- Journal Title
  
  ACS Chem Biol.
  
  Volume: 11 Issue: 2 Pages: 381-388
- DOI
  10.1021/acschembio.5b00751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15051
[Journal Article] Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs2016
- Author(s)
  Atsuto Inoue, Yuhei Nishimura, Norihito Matsumoto, Noriko Umemoto , Yasuhito Shimada, Toru Maruyama, Kana Kayasuga, Motohiko Morihara, Jun Katagi, Tsutomu Shiroya, Yasushi Hirota, Soonih Kim , Toshio Tanaka
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 3 Pages: 79-87
- NAID
  130005140185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15051
[Journal Article] Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity.2015
- Author(s)
  Nishimura Y, Sasagawa S, Ariyoshi M, Ichikawa S, Shimada Y, Kawaguchi K, Kawase R, Yamamoto R, Uehara T, Yanai T, Takata R, Tanaka T.
- Journal Title
  
  Front Pharmacol.
  
  Volume: 6
- DOI
  10.3389/fphar.2015.00199
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15051
[Journal Article] Zebrafish as a systems toxicology model for developmental neurotoxicity testing.2015
- Author(s)
  Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T.
- Journal Title
  
  Congenit Anom (Kyoto).
  
  Volume: 55 Issue: 1 Pages: 1-16
- DOI
  10.1111/cga.12079
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24510069, KAKENHI-PROJECT-25670127
[Journal Article] In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3)2015
- Author(s)
  Beibei Zhang, Yasuhito Shimada, Junya Kuroyanagi, Michiko Ariyoshi, Tsuyoshi Nomoto, Taichi Shintou, Noriko Umemoto,Yuhei Nishimura, Takeshi Miyazaki, Toshio Tanaka
- Journal Title
  
  Biomaterials
  
  Volume: 52 Pages: 14-25
- DOI
  10.1016/j.biomaterials.2015.02.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670127
[Journal Article] The effects of metal oxide nanoparticles on angiogenesis in transgenic zebrafish.2015
- Author(s)
  Chang J, Ichihara G, Shimada S, Tada-Oikawa S, Suzuki Y, Radwa S, Kato M, Tanaka T, Ichihara S.
- Journal Title
  
  J Nanosci Nanotechnol
  
  Volume: 15 Pages: 2140-2147
- NAID
  130004676483
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293149
[Journal Article] Downregulation of Stanniocalcin 1 is Responsible for Sorafenib-Induced Cardiotoxicity2015
- Author(s)
  Kawabata M, Umemoto N, Shimada Y, Nishimura Y, Zhang B, Kuroyanagi J, Miyabe M, Tanaka T.
- Journal Title
  
  Toxicological　Siences
  
  Volume: 143 Issue: 2 Pages: 374-384
- DOI
  10.1093/toxsci/kfu235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670127
[Journal Article] Copper oxide nanoparticles reduce vasculogenesis in transgenic zebrafish throufg down-regulation of VEGF expression and induction of apoptosis2015
- Author(s)
  J. Chang, G. Ichihara, Y. Shimada, S. Tada-Oikawa, J. Kuroyanagi, B. Zhang, Y. Suzuki, R. Sehsah, M. Kato, T. Tanaka, S. Ichihara
- Journal Title
  
  J Nanosci Nanotechnol
  
  Volume: 15 Issue: 3 Pages: 2140-2147
- DOI
  10.1166/jnn.2015.9762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24108002, KAKENHI-PROJECT-25670127
[Journal Article] Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers2015
- Author(s)
  Nishimura Y, Okabe S, Sasagawa S, Murakami S, Ashikawa Y, Yuge M, Kawaguchi K, Kawase R,Tanaka T.
- Journal Title
  
  Front Pharmacol.
  
  Volume: 6
- DOI
  10.3389/fphar.2015.00257
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15051
[Journal Article] Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors.2014
- Author(s)
  Zhang B, Shimada Y, Kuroyanagi J, Nishimura Y, Umemoto N, Nomoto T, Shintou T, Miyazaki T, Tanaka T.
- Journal Title
  
  Tumour Biology
  
  Volume: 35 Issue: 12 Pages: 11861-11869
- DOI
  10.1007/s13277-014-2417-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670127
[Journal Article] Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression2014
- Author(s)
  Junya Kuroyanagi, Yasuhito Shimada, Beibei Zhang, Michiko Ariyoshi, Noriko Umemoto, Yuhei Nishimura, Toshio Tanaka
- Journal Title
  
  FEBS Letters
  
  Volume: 588 Issue: 18 Pages: 3409-3416
- DOI
  10.1016/j.febslet.2014.07.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670127
[Journal Article] Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis2014
- Author(s)
  Masanori Hiramitsu, Yasuhito Shimada,Junya Kuroyanagi,Takashi Inoue,Takao Katagiri,Liqing Zang,Yuhei Nishimura,Norihiro Nishimura & Toshio Tanaka
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 3708-3708
- DOI
  10.1038/srep03708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670127, KAKENHI-PROJECT-25860294
[Journal Article] In vivo imaging of the mouse neurovascular unit under chronic cerebral hypoperfusion.2014
- Author(s)
  Yata K, Nishimura Y, Unekawa M, Tomita Y, Suzuki N, Tanaka T, Mizoguchi A, Tomimoto H.
- Journal Title
  
  Stroke.
  
  Volume: 45 Issue: 12 Pages: 3698-3703
- DOI
  10.1161/strokeaha.114.005891
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500422, KAKENHI-PROJECT-24510069, KAKENHI-PROJECT-25670127, KAKENHI-PROJECT-26350981
[Journal Article] Quantitative Phenotyping-Based In Vivo Chemical Screening in a Zebrafish Model of Leukemia Stem Cell Xenotransplantation2014
- Author(s)
  Beibei Zhang,Yasuhito Shimada,Junya Kuroyanagi,Noriko Umemoto,Yuhei Nishimura,Toshio Tanaka
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 1 Pages: e85439-e85439
- DOI
  10.1371/journal.pone.0085439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670127
[Journal Article] Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model2014
- Author(s)
  Liqing Zang, Yasuhito Shimada, Jumpei Kawajiria, Toshio Tanaka, Norihiro Nishimura
- Journal Title
  
  Journal of Functional Foods
  
  Volume: 10 Pages: 499-510
- DOI
  10.1016/j.jff.2014.08.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670127, KAKENHI-PROJECT-25860294
[Journal Article] Fluorescent-Based Methods for Gene Knockdown and Functional Cardiac Imaging in Zebrafish.2013
- Author(s)
  Umemoto N, Nishimura Y, Shimada Y, Yamanaka Y, Kishi S, Ito S, Okamori K, Nakamura Y, Kuroyanagi J, Zhang Z, Zang L, Wang Z, Nishimura N, Tanaka T.
- Journal Title
  
  Molecular Biotechnology
  
  Volume: 55 Issue: 2 Pages: 131-142
- DOI
  10.1007/s12033-013-9664-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670127, KAKENHI-PROJECT-25860294
[Journal Article] Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models.2013
- Author(s)
  Nishimura Y, Yata K, Nomoto T, Ogiwara T, Watanabe K, Shintou T, Tsuboyama A, Okano M, Umemoto N, Zhang Z, Kawabata M, Zhang B, Kuroyanagi J, Shimada Y, Miyazaki T, Imamura T, Tomimoto H, Tanaka T.
- Journal Title
  
  ACS Chem Neurosci.
  
  Volume: 4 Issue: 8 Pages: 1183-1193
- DOI
  10.1021/cn400010t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510069, KAKENHI-PROJECT-25670127
[Journal Article] A Novel, Reliable Method for Repeated Blood Collection from Aquarium Fish.2013
- Author(s)
  Zang L, Shimada Y, Nishimura Y, Tanaka T, Nishimura N.
- Journal Title
  
  Zebrafish
  
  Volume: 10 Issue: 3 Pages: 425-432
- DOI
  10.1089/zeb.2012.0862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670127, KAKENHI-PROJECT-25860294
[Journal Article] Downregulation of max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice.2013
- Author(s)
  Shimada Y, Kuroyanagi J, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T.
- Journal Title
  
  International Journal of Obesity (Lond)
  
  Volume: 217 Issue: 8 Pages: 1-8
- DOI
  10.1038/ijo.2013.217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670127
[Journal Article] S-nitrosylation regulates mitochondrial quality control via activation of2013
- Author(s)
  Ozawa K , Komatsubara AT, Nishimura Y, Sawada T, Kawafune H, Tsumoto H, Tsuji Y, Zhao J, Kyotani Y, Tanaka T, Takahashi R, Yoshizumi M
- Journal Title
  
  Scientific Reports
  
  Volume: 3: 2202 Issue: 1 Pages: 1-10
- DOI
  10.1038/srep02202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590306, KAKENHI-PROJECT-25670127
[Journal Article] In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish.2012
- Author(s)
  Watanabe K, Nishimura Y, Nomoto T, Umemoto N, Zhang Z, Zhang B, Kuroyanagi J, Shimada Y, Shintou T, Okano M, Miyazaki T, Imamura T, Tanaka T.
- Journal Title
  
  BMC Neuroscience
  
  Volume: 13 Issue: 1 Pages: 101-101
- DOI
  10.1186/1471-2202-13-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510069
[Journal Article] A High-Throughput Fluorescence-Based Assay System for Appetite-Regulating Gene and Drug Screening2012
- Author(s)
  Shimada Y, Hirano M, Nishimura Y,Tanaka T
- Journal Title
  
  PLoS ONE
  
  Volume: 7(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659136
[Journal Article] A High-Throughput Fluorescence-Based Assay System for Appetite-Regulating Gene and Drug Screening2012
- Author(s)
  Shimada Y, Hirano M, Nishimura Y, Tanaka T
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 12 Pages: e52549-e52549
- DOI
  10.1371/journal.pone.0052549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659136, KAKENHI-PROJECT-24590318
[Journal Article] Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish2012
- Author(s)
  Takahiro Hasumura, Yasuhito Shimada,Junya Kuroyanagi, Yuhei Nishimura,Shinichi Meguro, Yoshinori Takema and Toshio Tanaka
- Journal Title
  
  Nutrition & Metabolism
  
  Volume: 9 Pages: 73-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659136
[Journal Article] Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish2012
- Author(s)
  Takahiro Hasumura, Yasuhito Shimada, Junya Kuroyanagi,Yuhei Nishimura, Shinichi Meguro, Yoshinori Takema and Toshio Tanaka
- Journal Title
  
  Nutrition & Metabolism
  
  Volume: 9 Issue: 1 Pages: 73-73
- DOI
  10.1186/1743-7075-9-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659136
[Journal Article] Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model.2011
- Author(s)
  Tainaka T, Shimada Y, Kuroyanagi J, Zang L, Oka T, Nishimura Y, Nishimura N, Tanaka T.
- Journal Title
  
  Nutrition & metabolism
  
  Volume: 8 Issue: 1 Pages: 88-88
- DOI
  10.1186/1743-7075-8-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659136
[Journal Article] A novel protocol for the oral administration of test chemicals to adultz zebrafish2011
- Author(s)
  Liqing Zang, Daizo Morikane, Yasuhito Shimada, Toshio Tanaka, and Norihiro Nishimura
- Journal Title
  
  Zebrafish December
  
  Volume: 8(4) Pages: 203-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659136
[Journal Article] A novel protocol for the oral administration of test chemicals to adult zebrafish.2011
- Author(s)
  Zang L, Morikane D, Shimada Y, Tanaka T, Nishimura N.
- Journal Title
  
  Zebrafish
  
  Volume: 8 Issue: 4 Pages: 203-220
- DOI
  10.1089/zeb.2011.0726
- NAID
  120005228797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659136
[Journal Article] Changes in Cyclic Nucleotide Phosphodiesterase Activity and Calmodul in Concentration in Heart Muscle of Cardiomyopathic Hamsters.2004
- Author(s)
  Rumi Masunaga, Akio Nagasaka, Yoshikuni Sawai, Nobuki Hayakawa, Akira Nakai, Keiko Hotta, Yasuchika Kato, Hitoshi Hishida, Hisahide Takahashi, Michiko Naka, Yasuhito Shimada, Toshio Tanaka, Hiroyoshi Hidaka, Mitsuyasu Itoh
- Journal Title
  
  J Mol Cell Cardiol. 37(3)
  
  Pages: 767-774
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207003
[Journal Article] Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage.2004
- Author(s)
  Hirofumi Nikaido, Hiroshi Tsunoda, Yuhei Nishimura, Takaaki Kirino, Toshio Tanaka
- Journal Title
  
  Circulation 110(13)
  
  Pages: 1839-1846
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207003
[Journal Article] ファーマコジェノミックスと創薬ターゲットバリデーション2004
- Author(s)
  田中利男
- Journal Title
  
  癌治療と宿主 16・4
  
  Pages: 307-313
- Data Source
  KAKENHI-PROJECT-16659137
[Journal Article] ファーマコゲノミクスとファーマコインフォマティクス2004
- Author(s)
  田中利男
- Journal Title
  
  月刊薬事 46・6
  
  Pages: 37-44
- Data Source
  KAKENHI-PROJECT-16659137
[Journal Article] Target validation in hypoxia-induced vascular remodeling using transcriptome/metabolome analysis.2003
- Author(s)
  H.Amano, K Maruyama, Michiko Naka, T Tanaka
- Journal Title
  
  Pharmacogenomics J 3(3)
  
  Pages: 183-188
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207003
[Journal Article] Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene.2002
- Author(s)
  M.Hayashi, Y.Shimada, Y.Nishimura, T.Hama, T.Tanaka
- Journal Title
  
  Biochem.Biophys.Res.Commun. 297
  
  Pages: 1253-1258
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207003
[Journal Article] Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis.2002
- Author(s)
  Matsumoto Y, Oshida T, Obayashi I, Imai Y, Matsui K, Yoshida NL, Nagata N, Ogawa K, Obayashi M, Kashiwabara T, Gunji S, Nagasu T, Sugita Y, Tanaka T, Tsujimoto G, Katsunuma T, Akasawa A, Saito H.
- Journal Title
  
  Int Arch Allergy Immunol 129(4)
  
  Pages: 327-340
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207003
[Journal Article] Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.2002
- Author(s)
  Imai Y, Nakada A, Hashida R, Sugita Y, Tanaka T, Tsujimoto G, Matsumoto K, Akasawa A, Saito H, Oshida T.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 297
  
  Pages: 1282-1290
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207003
[Patent] 養殖魚類、畜産動物、ペット動物の内臓脂肪蓄積を抑制する素材、及び該素材を用いた動物用飼料2014
- Inventor(s)
  田中　利男,島田　康人,國永　史生,椎名　康彦,高橋　義宜
- Industrial Property Rights Holder
  田中　利男,島田　康人,國永　史生,椎名　康彦,高橋　義宜
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-14
- Data Source
  KAKENHI-PROJECT-25670127
[Patent] イメージング用小魚管理装置及びそれに用いられる小魚用イメージングプレート2014
- Inventor(s)
  田中　利男,島田　康人,梅本　紀子,小幡　勝,橋本　正敏
- Industrial Property Rights Holder
  田中　利男,島田　康人,梅本　紀子,小幡　勝,橋本　正敏
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-150299
- Filing Date
  2014-07-24
- Data Source
  KAKENHI-PROJECT-25670127
[Patent] がん細胞阻害薬、がん幹細胞検出用プローブ2013
- Inventor(s)
  田中利男,島田康人,西村有平,新藤太一,渡邉耕平,野本毅
- Industrial Property Rights Holder
  田中利男,島田康人,西村有平,新藤太一,渡邉耕平,野本毅
- Industrial Property Rights Type
  特許
- Filing Date
  2013-10-25
- Data Source
  KAKENHI-PROJECT-25670127
[Patent] 異種細胞移植モデル動物の作製方法2013
- Inventor(s)
  田中　利男,島田　康人,張　貝貝,黒栁　淳哉
- Industrial Property Rights Holder
  田中　利男,島田　康人,張　貝貝,黒栁　淳哉
- Industrial Property Rights Type
  特許
- Filing Date
  2013-10-18
- Data Source
  KAKENHI-PROJECT-25670127
[Presentation] Prognostic impact of preoperative psoas muscle Hounsfield unit at radical cystectomy for bladder cancer.2021
- Author(s)
  Sugino Yusuke、Sasaki Takeshi、Kato Manabu、Masui Satoru、Nishikawa Kouhei、Okamoto Takashi、Kajiwara Shinya、Shibahara Takuji、Onishi Takehisa、Tanaka Shiori、Kanda Hideki、Matsuura Hiroshi、Inoue Takahiro
- Organizer
  The 37th Korea-Japan Urological Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03066
[Presentation] 新規線毛症モデルゼブラフィッシュの作出2018
- Author(s)
  西村有平、笠原広介、青木啓将、清野透、王淑杰、弓削瑞葵、白水崇、田中利男、溝口明、五島直樹、稲垣昌樹
- Organizer
  第4回ゼブラフィッシュ・メダカ創薬研究会
- Data Source
  KAKENHI-PROJECT-16K08547
[Presentation] 新規嚢胞性腎疾患モデルゼブラフィッシュの開発2018
- Author(s)
  西村有平、笠原広介、青木啓将、清野透、王淑杰、弓削瑞葵、白水崇、田中利男、溝口明、五島直樹、稲垣昌樹
- Organizer
  第28回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-16K08547
[Presentation] トランスクリプトームを利用した肺高血圧の病態解析2018
- Author(s)
  西村有平、澤田博文、田中利男、三谷義英、丸山一男
- Organizer
  第47回日本心脈管作動物質学会年会シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08547
[Presentation] Differentially Expressed Genes in Early and Late Treatment for Occlusive Pulmonary Vasculopathy in Sugen/hypoxia Models: Molecular Basis for Early Treatment2017
- Author(s)
  Yoshihide Mitani, Hirofumi Sawada, Tsutomu Shinohara, Shoichiro Otsuki, Noriko Yodoya, Hiroyuki Ohashi, Taichi Kato, Erquan Zhang, Yuhei Nishimura, Toshio Tanaka, Kazuo Maruyama, Masahiro Hirayama.
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09688
[Presentation] トランスレーショナル薬理学とゼブラフィッシュ創薬2016
- Author(s)
  田中利男
- Organizer
  第89回日本薬理学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K15051
[Presentation] Zebrafish-Based Drug Discovery and Systems Pharmacology2016
- Author(s)
  田中利男
- Organizer
  International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research
- Place of Presentation
  岡崎コンファレンスセンター（愛知県・岡崎市）
- Year and Date
  2016-03-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15051
[Presentation] 肥大型心筋症の新規関連遺伝子GSTK1の発見と機能解析2016
- Author(s)
  西村有平、笹川翔太、岡部志功、村上宗一郎、芦川芳史、弓削瑞葵、川口幸輝、島田康人、岡本隆二、伊藤正明、田中利男
- Organizer
  第26回日本循環薬理学会
- Place of Presentation
  信州大学（長野県・松本市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-16K08547
[Presentation] ゼブラフィッシュ創薬と個別化医療の新展開2015
- Author(s)
  田中利男
- Organizer
  第62回日本実験動物学会
- Place of Presentation
  京都テルサ（京都府・京都市）
- Year and Date
  2015-05-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K15051
[Presentation] ゼブラフィッシュによるシステムズ栄養学のｸﾞﾛｰﾊﾞﾙ展開2015
- Author(s)
  田中利男
- Organizer
  第69回日本栄養・食糧学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2015-05-16
- Invited
- Data Source
  KAKENHI-PROJECT-15K15051
[Presentation] システムズ薬理学とゼブラフィッシュ創薬2015
- Author(s)
  田中利男
- Organizer
  第21回小型魚類研究会
- Place of Presentation
  大阪大学銀杏会館（大阪府・吹田市）
- Year and Date
  2015-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-15K15051
[Presentation] High Throughput Forward and Reverse Screen for Cardiotoxicology of Anticancer Drugs in Zebrafish2015
- Author(s)
  田中利男
- Organizer
  ZDM8
- Place of Presentation
  Boston（アメリカ合衆国）
- Year and Date
  2015-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15051
[Presentation] ゼブラフィッシュ創薬の新しい展開2015
- Author(s)
  田中利男
- Organizer
  第1回ゼブラフィッシュ創薬研究会
- Place of Presentation
  三重大学（三重県・津市）
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-15K15051
[Presentation] 次世代ゼブラフィッシュ創薬の新展開2015
- Author(s)
  田中利男
- Organizer
  第88回日本薬理学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-03-18
- Invited
- Data Source
  KAKENHI-PROJECT-25670127
[Presentation] ゼブラフィッシュを用いた創薬スクリーニング2015
- Author(s)
  西村有平、川瀬玲子、田中利男
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-24510069
[Presentation] ゼブラフィッシュ創薬の国際的展開2015
- Author(s)
  田中利男
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂（石川県・金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-15K15051
[Presentation] Systems Pharmacology for Retinal Diseases2015
- Author(s)
  Nishimura Y, Kawase R, Tanaka T
- Organizer
  The 88th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-03-20
- Invited
- Data Source
  KAKENHI-PROJECT-24510069
[Presentation] 分子標的薬の心毒性に関するシステムズ薬理学2015
- Author(s)
  田中利男
- Organizer
  第2回Onco-Cardiology Meeting
- Place of Presentation
  ソラシティカンファレンスセンター（東京都・千代田区）
- Year and Date
  2015-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-15K15051
[Presentation] 遺伝子改変ゼブラフィッシュを用いたニコチンの発達神経毒性評価2014
- Author(s)
  西村有平、村上宗一郎、芦川芳史、笹川翔太、川端美湖、梅本紀子、有吉美稚子、張貝貝、島田康人、田中利男
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2014-07-03
- Data Source
  KAKENHI-PROJECT-24510069
[Presentation] ゼブラフィッシュを用いたBBB機能イメージング2014
- Author(s)
  西村有平、梅本紀子、田中利男
- Organizer
  第9回トランスポーター研究会年会
- Place of Presentation
  名古屋市立大学
- Year and Date
  2014-06-14
- Invited
- Data Source
  KAKENHI-PROJECT-24510069
[Presentation] ゼブラフィッシュによる医薬品の生殖発生毒性評価2014
- Author(s)
  西村有平、田中利男、島田康人、梅本紀子
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2014-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-24510069
[Presentation] 医薬品の生殖発生毒性評価のためのパラダイムシフト2014
- Author(s)
  田中利男
- Organizer
  第41回日本毒性学会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2014-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-25670127
[Presentation] Biodistribution and effects of SiO2 NPs in mice and in a transgenic model of zebrafish (Danio rerio).2014
- Author(s)
  Sandra Vranic, Sahoko Ichihara, Yasuhito Shimada, Toshio Tanaka, Wenting Wu, Sonja Boland, Lang Tran, Gaku Ichihara
- Organizer
  The 7th International Congress of Nanotoxicology
- Place of Presentation
  The Congress Center in Limra Hotel & Resort, Antalya, Turkey
- Year and Date
  2014-04-23
- Data Source
  KAKENHI-PROJECT-26293149
[Presentation] ターゲットバリデーションとオミックス創薬スクリーニング2011
- Author(s)
  田中　利男
- Organizer
  ゲノム創薬フォーラム　談話会(招待講演)
- Place of Presentation
  日本薬学会館長井記念ホール
- Data Source
  KAKENHI-PROJECT-23659136
[Presentation] オミックス創薬科学におけるターゲットバリデーション2011
- Author(s)
  田中　利男
- Organizer
  第84回日本生化学会大会(招待講演)
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-23659136
[Presentation] 新しい生活習慣病モデルとオミックス医学2011
- Author(s)
  田中　利男
- Organizer
  第134回分泌セミナー(招待講演)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23659136
[Presentation] ターゲットバリテーションとオミックス創薬スクリーニング2011
- Author(s)
  田中利男
- Organizer
  ゲノム創薬フォーラム
- Place of Presentation
  日本薬学会館長井記念ホール
- Year and Date
  2011-11-09
- Data Source
  KAKENHI-PROJECT-23659136
[Presentation] オミックス創薬科学におけるターゲットバリテーション2011
- Author(s)
  田中利男
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23659136
[Presentation] 新しい生活習慣病モデルとオミックス医学2011
- Author(s)
  田中利男
- Organizer
  第134回分泌セミナー
- Place of Presentation
  東京都ノボノルディスクファーマ(株)
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-23659136
[Presentation] ゼブラフィッシュを用いた医薬品の安全性評価
- Author(s)
  田中利男
- Organizer
  第117回基礎研究部会総会
- Place of Presentation
  京都リサーチパーク
- Invited
- Data Source
  KAKENHI-PROJECT-25670127
[Presentation] バルプロ酸による催奇形性のシステムズ薬理学
- Author(s)
  村上宗一郎、西村有平、笹川翔太、芦川芳史、川端美湖、張貝貝、島田康人、梅本紀子、田中利男
- Organizer
  第54回日本先天異常学会学術年会
- Place of Presentation
  麻布大学
- Year and Date
  2014-07-26 – 2014-07-27
- Data Source
  KAKENHI-PROJECT-24510069
[Presentation] ゼブラフィッシュを用いた新しい発達神経毒性評価システム
- Author(s)
  西村有平、島田康人、田中利男
- Organizer
  日本先天異常学会
- Place of Presentation
  千里ライフサイエンスセンター
- Invited
- Data Source
  KAKENHI-PROJECT-24510069
[Presentation] ゼブラフィッシュによる新しい網膜保護機構解析
- Author(s)
  西村有平、梅本紀子、田中利男
- Organizer
  第34回日本眼薬理学会年会
- Place of Presentation
  長良川国際会議場
- Year and Date
  2014-09-13 – 2014-09-15
- Invited
- Data Source
  KAKENHI-PROJECT-24510069
[Presentation] 希少疾患と創薬
- Author(s)
  田中利男
- Organizer
  ゲノム創薬フォーラム第33回談話会
- Place of Presentation
  東大医科研講堂
- Invited
- Data Source
  KAKENHI-PROJECT-25670127
[Presentation] ターゲットバリデ―ションとシステム薬理学
- Author(s)
  田中利男
- Organizer
  Shikoku Synphony研究会
- Place of Presentation
  徳島
- Invited
- Data Source
  KAKENHI-PROJECT-25670127
[Presentation] ゼブラフィッシュによろ定量的システムズ薬理学
- Author(s)
  田中利男
- Organizer
  第46回筑波実験動物研究会
- Place of Presentation
  文科省研究交流センター
- Invited
- Data Source
  KAKENHI-PROJECT-25670127
[Presentation] In vivo fluorescent imaging of blood-brain barrier disruption in zebrafish using a novel dye.
- Author(s)
  Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T.
- Organizer
  DNT4
- Place of Presentation
  The Inn at Penn, Philadelphia, PA
- Year and Date
  2014-05-11 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-24510069
[Presentation] 中枢神経系のゼブラフィッシュ安全性システムズ薬理学
- Author(s)
  田中利男
- Organizer
  第5回日本安全性薬理研究会学術年会
- Place of Presentation
  東京大学弥生講堂一条ホール
- Invited
- Data Source
  KAKENHI-PROJECT-25670127
[Presentation] マウスと遺伝子改変ゼブラフィッシュにおけるシリカナノ粒子の生態分布と影響
- Author(s)
  ブラニッチ　サンドラ、市原佐保子、島田康人、田中利男、呉文亭、ボーランド　ソニア、トラン　ラン、市原学
- Organizer
  第84回日本衛生学会総会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-26293149

1. NAKA Michiko (10093139)

# of Collaborated Projects: 28 results

# of Collaborated Products: 7 results
2. NISHIMURA Yuuhei (30303720)

# of Collaborated Projects: 21 results

# of Collaborated Products: 47 results
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# of Collaborated Products: 28 results
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8. MUKAI Jun (70263019)

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# of Collaborated Projects: 1 results

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17. KOHAMA Kazuhiro (30101116)

# of Collaborated Projects: 1 results

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18. TAKANO-OHMURO Hiromi (00124470)

# of Collaborated Projects: 1 results

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19. ISHIKAWA Ryoki (20212863)

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20. KURODA Hideyo (50064845)

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24. Mitani Yoshihide (60273380)

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27. 斉藤俊行 (90205667)

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# of Collaborated Products: 0 results
32. 市原学 (90252238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
33. 澤田博文 (30362354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
34. 寺見文宏 (50370599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 山田佳代子 (90866948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 山本恭子 (90892480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 杉本和史 (60378370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 為田雅彦 (10626493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 井上貴博 (80511881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
40. 佐々木豪 (20644941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
41. 内田克典 (60362349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 加藤学 (60626117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
43. HAIZMANN C.W.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. ASAHI Yoshihiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. BERCHTOLD M.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. TOMITA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. OZAWA Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 加藤昌志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 田中宏昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 笠原広介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
51. 吉栖正典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tanaka Toshio 田中 利男

TANAKA Toshio 田中 利男

Research Projects

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がん分子標的薬のOncocardiology研究Principal Investigator

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in vivo Mechanisms of Novel Selective Fluorescent Leukemia Stem Cell InhibitorPrincipal Investigator

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Novel immunological tolerance in zebrafish of human cancer cell xenotransplants and cancer immunotherapy mechanismsPrincipal Investigator

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Identification of novel drug targets with Omics-based mechanismsfor obesity treatmentPrincipal Investigator

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薬理プロテオミクスの創成と展開Principal Investigator

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脳血管障害におけるゲノム創薬ターゲットの作用機構解析Principal Investigator

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脳血管障害におけるゲノム創薬ターゲット探索法の開発Principal Investigator

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Tanaka Toshio 田中利男

TANAKA Toshio 田中利男