Akagi Kiwamu 赤木究

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AKAGI Kiwamu 赤木究

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Researcher Number	30244114
Other IDs
Affiliation (Current)	2023: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 病院腫瘍診断・予防科, 科長(兼)診療部長
Affiliation (based on the past Project Information) *help	2021 – 2022: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 病院腫瘍診断・予防科, 科長(兼)部長 2016 – 2020: 埼玉県立がんセンター(臨床腫瘍研究所), 病院腫瘍診断・予防科, 科長(兼)部長 2015: 埼玉県立がんセンター(臨床腫瘍研究所), その他部局等, その他 2000: 埼玉県立がんセンター研究所, 室長 1999 – 2000: 埼玉県立がんセンター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Human genetics Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Biological pharmacy / Biological Sciences
Keywords	Principal Investigator がん関連遺伝子 / ＲＮＡシークエンス / 胚細胞性変異 / 原因遺伝子 / 若年癌 / 分子バーコード / RNAシーケンス / MSI検査 / パネル検査 / 若年性大腸癌 … More / DKC1 / シーケンス / 大腸がん / 若年がん … More Except Principal Investigator リンチ症候群 / ミスマッチ修復遺伝子 / コホート研究 / NK活性 / 遺伝子治療 / トランスジェニックマウス / アンチセンス / 融合遺伝子 / 白血病 / リボザイム / 医療の地域間格差 / 家系単位での遺伝医療 / 遺伝性腫瘍 / 遠隔診療ネットワーク / 遺伝診療 / オンライン診療 / Lynch-like syndrome / 遺伝性腫瘍症候群 / 免疫チェックポイント阻害剤 / 次世代シーケンサー / マイクロサテライト不安定性 / 大腸がん / MSH6 / 大腸癌 / NSG / 胃がん / NGS / MSI検査 / Immunosurveillance / NK activity / Prospective cohort study / 免疫監視 / マイクロアレイ / 遺伝子 / 遺伝子発現プロファイル / 機能ゲノム科学 / 創薬 / 緑茶 / エストロゲンレセプター / がん化学予防 / 発がんリスク / EGCG / hnRNP / エストロゲンレセプターα / H.pylori / 免疫 / H. pylori / 血清α_2-グロブリン / 前がん病変マーカー / hnRNP B1 / Tip(TNF-α inducing protein) / がん予防 / NKG2D / 乳がん / 肺がん / ピロリ菌 / コーホート研究 / 遺伝子多型 Less

Lynch-like syndrome include hereditary cases difficult to diagnose.
- Principal Investigator
  
  山本剛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Research Institute for Clinical Oncology Saitama Cancer Center
オンライン遺伝診療：家系単位での遺伝医療を実現する遠隔診療ネットワークの構築
- Principal Investigator
  
  植野さやか
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Okayama University
マイクロサテライト不安定性検査の定量化はMSI-Hの検出感度を向上させる
- Principal Investigator
  
  山本剛
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Research Institute for Clinical Oncology Saitama Cancer Center
Analysis of responsible genes in early-onset colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Akagi Kiwamu
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center
白血病の原因となる融合遺伝子mRNAを標的とするリボザイムの設計
- Principal Investigator
  
  神津知子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center
がん関連遺伝子発現の個体差と宿主・環境要因に関する研究
- Principal Investigator
  
  NAKACHI Kei
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Radiation Effects Research Foundation
  Research Institute for Clinical Oncology, Saitama Cancer Center
創薬、医療を目的とした「機能ゲノム科学」の戦略的手法の樹立
- Principal Investigator
  
  内田和彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Tsukuba
白血病の原因となる融合遺伝子mRNAを標的とするリボザイムの設計
- Principal Investigator
  
  神津知子
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center
DEVELOPMENT OF BIOLOGICAL MARKERS FOR INDIVIDUAL CANCER RISK AND CANCER PREVENTION ON THE BASIS OF A PROSPECTIVE COHORT STUDY
- Principal Investigator
  
  NAKACHI Kei
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center

All 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Quantitative evaluation of MSI testing using NGS detects the imperceptible microsatellite changed caused by MSH6 deficiency2020
- Author(s)
  Yamamoto Gou、Takenoya Takashi、Takahashi Akemi、Osanai Yukiko、Kakuta Miho、Tachikawa Tetsuhiko、Washio Takanori、Kamiyama Masato、Shiibashi Michio、Yamaguchi Shigeki、Akagi Kiwamu
- Journal Title
  
  Familial Cancer
  
  Volume: 20 Issue: 2 Pages: 137-143
- DOI
  10.1007/s10689-020-00203-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07339
[Journal Article] SVA retrotransposon insertion in exon of MMR genes results in aberrant RNA splicing and causes Lynch syndrome2020
- Author(s)
  Yamamoto Gou、Miyabe Izumi、Tanaka Keisuke、Kakuta Miho、Watanabe Motoko、Kawakami Satoru、Ishida Hideyuki、Akagi Kiwamu
- Journal Title
  
  European Journal of Human Genetics
  
  Volume: 29 Issue: 4 Pages: 680-686
- DOI
  10.1038/s41431-020-00779-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07339
[Journal Article] Development of metachronous rectal cancers in a young man with dyskeratosis congenita: a case report.2019
- Author(s)
  Watanabe M, Yamamoto G, Fujiyoshi K, Akagi Y, Kakuta M, Nishimura Y, Akagi K.
- Journal Title
  
  J Med Case Rep.
  
  Volume: 13 Issue: 1 Pages: 117-122
- DOI
  10.1186/s13256-019-2044-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08335
[Journal Article] Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing2017
- Author(s)
  Gou Yamamoto, Mari Kikuchi, Shiho Kobayashi, Yoshiko Arai, Kenji Fujiyoshi, Tomokazu Wakatsuki, Miho Kakuta, Yuki Yamane, Yoshihito Iijima, Hideaki Mizutani, Yuki Nakajima, Junko Sudo, Hiroyasu Kinoshita, Futoshi Kurimoto, Hirohiko Akiyama, Hidetaka Uramoto, Hiroshi Sakai, Yoshito Akagi, Kiwamu Akagi
- Journal Title
  
  International journal of oncology
  
  Volume: 50 Issue: 5 Pages: 1579-1589
- DOI
  10.3892/ijo.2017.3935
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08335, KAKENHI-PROJECT-17K10803
[Presentation] An update on hereditary tumors Construction of Integrated Database of Clinical and Genetic Information for Lynch syndrome in Japan2018
- Author(s)
  赤木究, 山本剛, 松下一之, 檜井孝夫, 横井左奈, 田中屋宏爾, 松原長秀, 冨田尚裕, 石田秀行
- Organizer
  第77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08335
[Presentation] 多数の大腸腺腫を併発した日本人若年発症直腸癌患者におけるMBD4遺伝子生殖細胞系列病的変異の同定と直腸癌組織における体細胞変異プロファイルの解析2018
- Author(s)
  江口　英孝、田中屋　宏爾、田夛　祐喜、立川　哲彦、平田　智子、神田　将和、井谷　史嗣、赤木　究、岡崎　康司、石田　秀行
- Organizer
  第24回日本家族性腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08335
[Presentation] NGSを用いたCNV検出によるLynch症候群病的バリアントの確定2018
- Author(s)
  山本　剛、宮部　泉、高橋　朱実、須藤　久美子、石川　志帆、新井　吉子、菊地　茉莉、田中　桂輔、若月　智和、立川　哲彦、角田　美穂、横井　左奈、檜井　秀夫、松下　一之、赤木　究
- Organizer
  第24回日本家族性腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08335
[Presentation] Multi-gene panel を用いた遺伝性大腸がんの遺伝子診断2018
- Author(s)
  赤木究、山本剛、宮部泉、角田美穂、若月智和、田中佳輔、中村篤大、山下健太郎、山口達郎、三口真司、須藤剛、永坂岳司、塩澤学、中野雄介、野水整、安田有里、主藤朝也、稲田麻里、賀川義規、富田佳典
- Organizer
  日本人類遺伝学会第63回大会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08335
[Presentation] Analyzing pathogenic variants in Lynch syndrome by DNA and RNA sequencing2018
- Author(s)
  山本剛, 新井吉子, 立川哲彦, 赤木究
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K08335
[Presentation] 遺伝性腫瘍症候群　－治療とがん予防－2017
- Author(s)
  赤木究
- Organizer
  第76回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08335
[Presentation] 遺伝性大腸がん及びポリポーシス症候群：リンチ症候群と家族性大腸腺腫症2017
- Author(s)
  赤木究
- Organizer
  第15回日本臨床腫瘍学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08335
[Presentation] Molecular features of microsatellite instability-high colorectal cancer and mutation spectrum of Lynch syndrome identified by universal tumor screening.2017
- Author(s)
  Kiwamu Akagi, Miho Kakuta, Gou Yamamoto, Kenji Fujiyoshi, Yoji Nishimura, Yoshito Akagi, Hirohiko Sakamoto.
- Organizer
  InSiGHT 7TH BIENNIAL meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08335
[Presentation] リンチ症候群の臨床ゲノムデータベース構築に向けた取り組み2017
- Author(s)
  山本剛，角田美穂，新井冨生，石田秀行，岡﨑康司，隈元謙介，田中屋宏爾，永坂岳司，野水　整，檜井孝夫，三口真司，松原長秀，山口達郎，山下健太郎，赤木究
- Organizer
  第23回家族性腫瘍学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08335
[Presentation] 日本家族性腫瘍学会におけるゲノムデータベース構築2017
- Author(s)
  赤木究
- Organizer
  第23回家族性腫瘍学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08335
[Presentation] Mutation spectrum of Japanese Lynch syndrome patients diagnosed by Universal tumor screening for colorectal cancer2016
- Author(s)
  Kiwamu Akagi
- Organizer
  ICHG
- Place of Presentation
  京都
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08335

1. 山本剛 (80384189)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. 高橋朱実 (40743620)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. NAKACHI Kei (00142117)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. IMAI Kazue (80260230)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 神津知子 (60161874)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 末岡榮三朗 (00270603)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 角田美穂 (60347359)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
8. MATSUYAMA Satoru (90311373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. EGUCHI Hidetaka (00260232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 福山朋房 (10300906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 林慎一 (60144862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 菅沼雅美 (20196695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 三宅智 (00332346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 大倉康男 (30312284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 内田和彦 (90211078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 斉藤俊行 (90205667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田中利男 (00135443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 辻本豪三 (80172013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 村上康文 (90200279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 宮部泉 (20800155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 井内勝哉 (40553847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 植野さやか (80848937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 田村和朗 (20278823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 平沢晃 (90296658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 吉田玲子 (10421166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 植木有紗 (60445319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SHARP G・B

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Akagi Kiwamu 赤木 究

AKAGI Kiwamu 赤木 究

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Analysis of responsible genes in early-onset colorectal cancerPrincipal Investigator

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[Journal Article] Quantitative evaluation of MSI testing using NGS detects the imperceptible microsatellite changed caused by MSH6 deficiency2020

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[Journal Article] SVA retrotransposon insertion in exon of MMR genes results in aberrant RNA splicing and causes Lynch syndrome2020

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[Journal Article] Development of metachronous rectal cancers in a young man with dyskeratosis congenita: a case report.2019

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[Journal Article] Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing2017

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[Presentation] An update on hereditary tumors Construction of Integrated Database of Clinical and Genetic Information for Lynch syndrome in Japan2018

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Data Source

[Presentation] 多数の大腸腺腫を併発した日本人若年発症直腸癌患者におけるMBD4遺伝子生殖細胞系列病的変異の同定と直腸癌組織における体細胞変異プロファイルの解析2018

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[Presentation] NGSを用いたCNV検出によるLynch症候群病的バリアントの確定2018

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Akagi Kiwamu 赤木究

AKAGI Kiwamu 赤木究

[Presentation] 遺伝性腫瘍症候群　－治療とがん予防－2017