• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Saito Naoki  齋藤 直樹

ORCIDConnect your ORCID iD *help
… Alternative Names

SAITO NAOKI  齋藤 直樹

SAITO Naoki  齋藤 直樹

齋藤 直樹  サイトウ ナオキ

斉藤 直樹  サイトウ ナオキ

斎藤 直樹

Less
Researcher Number 80142545
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2015 – 2019: 明治薬科大学, 薬学部, 教授
2011 – 2013: 明治薬科大学, 薬学部, 教授
2005: 明治薬科大学, 薬学部, 教授
2004 – 2005: 明治薬科大学, 助教授
2002 – 2004: 明治薬科大学, 薬学部, 助教授 … More
1998 – 2000: 明治薬科大学, 薬学部, 講師
1991 – 1992: 明治薬科大学, 薬化学教室, 助手
1989: 明治薬科大学, 薬化学教室, 助手
1988 – 1989: 明治薬科大学, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Chemical pharmacy / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Except Principal Investigator
Chemical pharmacy
Keywords
Principal Investigator
レニエラマイシン / 海洋天然物 / 構造活性相関 / 全合成 / 抗腫瘍活性 / 化学変換 / 合成 / 制癌剤 / エクチナサイジン / 構造解析 … More / 開発 / 抗がん剤 / 光変換 / 1,3-ジオキソール / サフラマイシン / 1,2,3,4-テトラヒドロイソキノリン / 光反応 / 反応機構 / ラジカル反応 / 殺細胞活性 / テトラヒドロイソキノリン / Isoquinoline Alkaloid / Chemical Transformation / Structure Activity Relationship / Anticancer Agent / Oxidative Degradation / Jorunnamycin / Renieramycin / Marine Natural Product / 酸化的分解反応 / ジョルマイシン / ウミウシ / 海綿 / アルカロイド / 天然物化学 / 海洋資源 / 創薬 / イソキノリンアルカロイド / 酸化的分解 / ジョルナマイシン / タイ王国 / 国際情報交流 / フィリピン / タイ / 構造決定 / 国際情報交換 / 国際共同研究 / イソキノリン … More
Except Principal Investigator
全合成 / 海洋天然物 / イソキノリン / Isoquinoline / サフラマイシン / アルカロイド / Total Synthesis / Ecteinascidin / Natural Marine Product / 部分合成 / 保護基 / エクチナサイジン / total synthesis / marine natural product / 抗腫瘍活性 / Protective Group / Piperazine-2,5-dione / Piperazine / Partial Synthesis / Saframycin / Antibiotics / 立体化学 / 超電導NMRスペクトル / 立体選択的合成 / レニエラマイシンA / サフラマイシンA / ピペラジン-2.5ジオン / ピペラジン-2、5-ジオン / イソキノリンキノン / ピペラジンー2,5ージオン / ピペラジン / 抗生物質 / Large amount Supply / Structure Elucidation / Anticancer Drug / Renieramy / Alkaloid / 変換反応 / 酸化的分解反応 / ジョルマイシン / 養殖 / 炭素繊維 / エステル化 / 脱N-メチル化 / 制癌剤 / イソキノリンアルカロイド / 大量供給 / 構造解析 / 制がん剤 / レニエラマイシン / Anti-cancer Agent / Regioselective / Protecting Group / Baeyer-Villiger Reaction / 制癌活性 / 位置選択性 / フェノール保護基 / 位置選択的 / バイヤー・ビリガー反応 / polycyclic heteroaromatic compound / alkaloid / pyrroloacridine / 芳香族化合物 / 縮合多環芳香族化合物 / ピロロアクリジン / antitumor activity / opioid / structure elucidation / isoquinoline / indole / Mitragyna spociosa / 化学合成 / オピオイド受容体 / ミトラガイニン / オピオイド / 構造決定 / インドール / ミトラガイナ スペシオーサ / Aromatic alkaloid / Marine natural product / Quinolinequinone / Naphthoquinone / Total synthesis / Diels-Alder reaction / Aza-diene / Iminoquinolinequinone / AMV阻害活性 / キノリノン / DielsーAlder反応 / Diels‐Alder反応 / 芳香族アルカロイド / キノリンキノン / ナフトキノン / Diels-Alder反応 / アザジエン / イミノキノリンキノン Less
  • Research Projects

    (10 results)
  • Research Products

    (141 results)
  • Co-Researchers

    (12 People)
  •  Synthesis of biologically active marine natural products based on a novel photo-chemical transformation to develop medicinal chemistryPrincipal Investigator

    • Principal Investigator
      齋藤 直樹
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Meiji Pharmaceutical University
  •  Preparaion of Novel Anticancer Agents based on Isoquinoline Marine Natural ProductsPrincipal Investigator

    • Principal Investigator
      Saito Naoki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Meiji Pharmaceutical University
  •  Development for medicinal chemistry on antitumor isoquinoline marine natural products as lead compoundPrincipal Investigator

    • Principal Investigator
      SAITO NAOKI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Meiji Pharmaceutical University
  •  Development of practical supply of isoquinoline marine natural products to designate the creation of the new anticancer agentsPrincipal Investigator

    • Principal Investigator
      SAITO Naoki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Meiji Pharmaceutical University
  •  Medicinal chemistry on marine alkaloid as a seed of the development for a new anticancer drug in Malaya area

    • Principal Investigator
      KUBO Akinori
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Faculty of Pharmaceutical Sciences, Meiji Pharmaceutical University
  •  Medicinal Chemistry on Alkaloids from Plants in Malaya Area

    • Principal Investigator
      KUBO Akinori
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Chemical pharmacy
    • Research Institution
      MEIJI PHARMACEUTICAL UNIVERSITY
  •  ピロロ〔2,3,4-kl]アクリジン骨格を有する生理活性天然物の合成

    • Principal Investigator
      KITAHARA Yoshiyasu
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      MEIJI PHARMACEUTICAL UNIVERSITY
  •  Synthetic Approach to the Total Synthesis of Natural Marine Isoquinoline Alkaloid

    • Principal Investigator
      KUBO Akinori
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      MEIJI PHARMACEUTICAL UNIVERSITY
  •  Synthetic Studies on Biological Active Marine Natural Products Possessing Iminoquinolinequinone Structure

    • Principal Investigator
      KUBO Akinori
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Meiji College of Pharmacy
  •  Syntheses of biological active natural products having highly alkylated piperazine ring

    • Principal Investigator
      KUBO Akinori
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Meiji College of Pharmacy

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2005 2004 2003 2000 Other

All Journal Article Presentation Patent

  • [Journal Article] Structure-activity relationships and molecular docking analysis of Mcl-1 targeting renieramycin T analogues in patient-derived lung cancer cells2020

    • Author(s)
      Petsri K., Yokoya M., Tungsukruthai S., Rungrotmongkol T., Nutho B., Vinayanuwattikun C., Saito N., Matsubara T., Sato R, Chanvorachote P.
    • Journal Title

      Cancers

      Volume: 12 (4) Issue: 4 Pages: 875-875

    • DOI

      10.3390/cancers12040875

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06561, KAKENHI-PROJECT-20K06977
  • [Journal Article] Chemistry of renieramycins Part 18. Synthesis of renieramycin M and so-called fennebricin A from (+/-)-jorunnamycin A2020

    • Author(s)
      Yokoya M., Monden K., Sato M., Sirimangkalakitti N., Saito N.
    • Journal Title

      Heterocycles

      Volume: 101 (2) Issue: 2 Pages: 548-558

    • DOI

      10.3987/com-19-s(f)45

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Journal Article] Preparation of tricyclic analog as CDE ring model of renieramycin marine natural product by novel photo-induced transformation of 6-methoxy-1,2,3,4-tetrahydroisoquinoline-8,8-dione2019

    • Author(s)
      Yokoya M., Takahashi S., Saito N.
    • Journal Title

      Heterocycles

      Volume: 99 (2) Pages: 1276-1303

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Journal Article] Asymmetric synthesis and cytotoxicity evaluation of right-half models of antitumor renieramycin marine natural products2019

    • Author(s)
      Matsubara T., Yokoya M., Sirimangkalakitti N., Saito N.
    • Journal Title

      Marine Drugs

      Volume: 17 (1) Issue: 1 Pages: 3-3

    • DOI

      10.3390/md17010003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Journal Article] Synergistic cytotoxicity of renieramycin M (RM) and doxorubicin (DOX) in MCF-7 breast cancer cells2019

    • Author(s)
      Tun J., Salvador-Reyers L., Velarde M., Saito N., Suwanborirux K., Concepcion G.
    • Journal Title

      Marine Drugs

      Volume: 17 (9) Pages: 536-536

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Journal Article] Preparation of tricyclic anakog as CDE ring model of renieramycin marine natural product by novel photo-induced transformation of 6-methoxy-1,2,3,4-tertahydroisoquinoline-5,8-dione2019

    • Author(s)
      Yokoya M., Takahashi S., Saito N.
    • Journal Title

      Heterocycles

      Volume: 99 Issue: 2 Pages: 0000-0000

    • DOI

      10.3987/com-18-s(f)100

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Journal Article] 5-O-Acetylrenieramycin T from blue spnge Xestospongia sp. Induces Lung cncer stem cell apoptosis2019

    • Author(s)
      Chantarawrong W., Chamni S., Suwanborirux K., Saito N., Chanvorachote P.
    • Journal Title

      Marine Drugs

      Volume: 17 Issue: 2 Pages: 17-17

    • DOI

      10.3390/md17020109

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Journal Article] Construction of the pentacyclic core and formal total synthesis of (rac)-renieramycin T2018

    • Author(s)
      Kimura S., Saito N.
    • Journal Title

      ChemistryOpen

      Volume: 7 Issue: 10 Pages: 764-771

    • DOI

      10.1002/open.201800178

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Journal Article] A stereocontrolled total synthesis of (+/-)-saframycin A2018

    • Author(s)
      Kimura S., Saito N.
    • Journal Title

      Tetrahedron

      Volume: 74 Issue: 34 Pages: 4504-4514

    • DOI

      10.1016/j.tet.2018.07.017

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Journal Article] Preparation of Chiral Right-half Models of Antitumor Bistetrahydroisoquinolinequinone Natural Products2018

    • Author(s)
      Senbonmatsu Y.、Kimura S.、Akiba M.、Ando S. Saito N.
    • Journal Title

      HETEROCYCLES

      Volume: 97 Issue: 2 Pages: 1050-1067

    • DOI

      10.3987/com-18-s(t)88

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873, KAKENHI-PROJECT-18K06561
  • [Journal Article] Chemistry of renieramycins. 16. Structure of 7-desmethylrenieramycin O (= 14a-hydroxyrenieramycin S) from blue sponge, Xestospongia sp.2017

    • Author(s)
      Saito N., Hiramatsu A., Hirade H., Kubota M., Toyoshima R., Fujino A., Sirimangkalakitti N., Suwanborirux K., Concepcion G. P..
    • Journal Title

      Heterocycels

      Volume: 95 Issue: 2 Pages: 748-752

    • DOI

      10.3987/com-16-s(s)77

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer's disease2017

    • Author(s)
      Puksasook T., Kimura S., Tadtong S., Jiaranakulwanitch J., Pratungdejkul J., Kitphari W., Suwanborirux K., Saito N. Nukoolkarn V.
    • Journal Title

      J. Nat. Med.

      Volume: 71 Issue: 4 Pages: 665-682

    • DOI

      10.1007/s11418-017-1097-2

    • NAID

      40021337926

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] Chemistry of renieramycins. 17. A new generation of renieramycins: 5-O-monohydroquinone analogues of renieramycin M as potential cytotoxic agents against non-small-cell lung cancer cells2017

    • Author(s)
      Chamni S., Sirimangkalakitti N., Chanvorachote P., Saito N., Suwanborirux K.
    • Journal Title

      J. Nat. Prod.

      Volume: 80 Pages: 1541-1547

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] 天然物をツール・情報源とする低分子医薬品の創薬研究2017

    • Author(s)
      齋藤直樹
    • Journal Title

      ファルマシア

      Volume: 53 Pages: 555-559

    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] Apoptosis-inducing Effect of Hydroquinone 5-O-Cinnamoyl Ester Analog of Renieramycin M on Non-small Cell Lung Cancer Cells2017

    • Author(s)
      Matuthed A., Pinkhien T., Chamni S., Suwanborirux K., Saito N., Petpiroon N., Chanvorachote C.
    • Journal Title

      Anticancer Research

      Volume: 37 Issue: 11 Pages: 6259-6267

    • DOI

      10.21873/anticanres.12077

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] Chemistry of renieramycins. 17. A new generation of renieramycins: Hydroquinone 5-O-monoester analogues of renieramycin M as potential cytotoxicity agents against non-small -cell lung cancer cell2017

    • Author(s)
      Chamni S., Sirimangkalakitti N., Chanvorachote P., Saito N., Suwanborirux k.
    • Journal Title

      J. Nat. Prod.

      Volume: 80 Issue: 5 Pages: 1541-1547

    • DOI

      10.1021/acs.jnatprod.7b00068

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] Chemistry of renieramycins. Part 15. Synthesis of 22-O-ester derivatives of jorunnamycin A and their cytotoxicity against nonsmall lung cancer cells2016

    • Author(s)
      Sirimangkalakitti N., Chamni S., Charupant K., Chanvorachote P., Mori N., Saito N., Suwanborirux K.
    • Journal Title

      J. Nat. Prod.,

      Volume: 79 Issue: 8 Pages: 2089-2093

    • DOI

      10.1021/acs.jnatprod.6b00433

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] Chemistry of ecteinascidins. Part 5. An additional proof of cytotoxicity evaluation of ecteinascidin 770 derivatives2016

    • Author(s)
      Toyoshima R., Mori N., Suzuki T., Lowtangkicharoen W., Suwanborirux K., Saito N.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 65 Pages: 0000-0007

    • NAID

      130005160038

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] Bishydroquinone renieramycin M induced human lung cancer cell apoptosis through mitochondria-dependent pathway2016

    • Author(s)
      Pinkhien T., Maiuthes A., Chamni S., Suwanborirux K., Saito N., Chanvorachote P.
    • Journal Title

      Anticancer Res.

      Volume: 36 Issue: 12 Pages: 6327-6333

    • DOI

      10.21873/anticanres.11229

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] Stereoselective total synthesis of (-)-renieramycin T2016

    • Author(s)
      Yokoya M., Toyoshima R., Suzuki T., Le V. H., Williams R. M., Saito N.
    • Journal Title

      J. Org. Chem.

      Volume: 81 Issue: 10 Pages: 0001-0009

    • DOI

      10.1021/acs.joc.6b00327

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873, KAKENHI-PROJECT-15K08083
  • [Journal Article] Practical synthesis of tricyclic lactam model of antitumor renieramycin-saframycin natural products2016

    • Author(s)
      Yokoya M., Fujino A., Yaguchi A., Yamazaki M., Saito N.
    • Journal Title

      Heterocycles

      Volume: 93 Issue: 2 Pages: 802-802

    • DOI

      10.3987/com-15-s(t)53

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] 抗腫瘍活性レニエラマイシン海洋天然物の化学的研究2015

    • Author(s)
      横屋正志、齋藤直樹
    • Journal Title

      有機合成化学協会誌

      Volume: 73 Pages: 723-736

    • NAID

      130005093745

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] Chemistry of renieramycins. Part 14. Total synthesis of renieramycin I and practical synthesis of cribrostatin 4 (renieramycin H)2015

    • Author(s)
      Yokoya M., Kobayashi K. Sato M., Saito N.
    • Journal Title

      Marine Drugs

      Volume: 13 Issue: 8 Pages: 4915-4933

    • DOI

      10.3390/md13084915

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Journal Article] Isolation, structure characterization, and synthesis of stabilized 1,2,3,4-tetrahydroisoquinline marine natural product from pretreated Thai tunicate Ecteinascidia thrstoni with potassium cyanide2014

    • Author(s)
      Kimura S., Pangkruang W., Yokoya M., Honda A., Puthongking P., Suwanborirux K., Saito N.
    • Journal Title

      Heterocycles

      Volume: 88 (1) Issue: 1 Pages: 363-375

    • DOI

      10.3987/com-13-s(s)32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Preparation of tricyclic lactam model compounds of renieramycin and saframycin anticancer natural products from common intermediate2013

    • Author(s)
      Nakai K., Yokoya M., Saito N.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 61(8) Pages: 853-869

    • NAID

      130003360817

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Ecteinasicin 770, a tetrahydroisoquinoline alkaloid, sensitized human lung cancer celss to anokis2013

    • Author(s)
      Powan P., Saito N., Suwanborirux K., Chanvorachote P.
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 505-512

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Chemistry of Ecteinascidins. Part 4. Preparation of 2'-N-Acyl Ecteinascidin 770 Derivatives with Improved Cytotoxicity Profiles2013

    • Author(s)
      Mitsuhiro Tsujimoto, Witaya Lowtangkitcharoen, Nanae Mori, Waree Pangkruang, Ploenthip Puthongking, Khanit Suwanborirux, Naoki Saito
    • Journal Title

      Chem Pharm. Bull

      Volume: 61 Pages: 1052-1064

    • NAID

      130004137252

    • URL

      https://www.jstage.jst.go.jp/article/cpb/61/10/61_c13-00525/_pdf

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Replacement of a Quinone by 5-O-Acetylhydroquinone Abolishes the Accidental Necrosis Inducing Effect While Preserving theApoptosis-Inducing Effect of Renieramycin M on Lung Cancer Cells2013

    • Author(s)
      Thaniwan Cheun-Arom, Pithi Chanvorachote, Natchanun Sirimangkalakitti, Takushina Chuanasa, Naoki Saito, Ikuo Abe, Khanit Suwanborirux
    • Journal Title

      J. Nat. Prod

      Volume: 76 Pages: 1468-1474

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Preparation of Tricyclic Lactam Model Compounds of Renieramycin and Saframycin Anticancer natural Products from Common Intermediate2013

    • Author(s)
      Keiyo Nakai, Masashi Yokoya, Naoki Saito
    • Journal Title

      Chem. Pharm. Bull

      Volume: 61 Pages: 853-869

    • NAID

      130003360817

    • URL

      https://www.jstage.jst.go.jp/article/cpb/61/8/61_c13-00361/_pdf

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Chemistry of ecteinascidins. Part 4. Preparation of 2'-N-acyl ecteinascidin 770 analogues with improved cytotoxicity profiles2013

    • Author(s)
      Tsujimoto M., Lowtangkitcharoen W., Mori N., Pangkruang W., Puthongking P., Suwanborirux K., Saito N.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 61(10) Pages: 1052-1064

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Ecteinascidin 770, a Tetrahydroisoquinoline Alkaloid, Sensitizees human lung Cancer Cells to Anoikis2013

    • Author(s)
      Phattrakorn Powan, Naoki Saito, Khanit Suwanborirux, Pithi Chanvorachote
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 505-512

    • URL

      http://ar.iiarjournals.org/content/33/2/505.full.pdf+html

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Pepracement of a quinone by a 5-O-acetylhydroquinone abolishes accididental necrosis-inducing effect while preserving apoptosis-inducing effect to renieramycin M in lung cancer cells2013

    • Author(s)
      Cheun-Arom T., Chanvorachote P., Sitimangkalkakitti N., Chuanasa T., Saito N., Abe I., Suwanborirux K.
    • Journal Title

      J. Nat. Prod.

      Volume: 76 Issue: 8 Pages: 1468-1474

    • DOI

      10.1021/np400277m

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Chemistry of Renieramycins. Part 12. An Improved Total Synthesis of (±)-Renieramycin G2012

    • Author(s)
      Masashi Yokoya, Kimiko Shinada-Fujino, Saiko Masahiro Mimura, Yoshida, Hiroki Takada, Naoki Saito
    • Journal Title

      Tetrahedron

      Volume: 68 Issue: 22 Pages: 4166-4181

    • DOI

      10.1016/j.tet.2012.03.105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Chemistry of Renieramycins. Part 10. Structure of Renieramycin V, A Novel Renieramycin Marine Natural Product Having a Sterol Ether at C-14 position2012

    • Author(s)
      Naoki Saito, Miho Yoshino, Kornvika Charupant, Khanit Suwanborirux
    • Journal Title

      Heterocycles

      Volume: 84 Issue: 1 Pages: 309-314

    • DOI

      10.3987/com-11-s(p)28

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article]2012

    • Author(s)
      Mari Tatsukawa, Louvy Lynn C.Punzalan,Hilbert D. S. Magpantay, Irene M. Villasenñr, Gisela P. Concepcion, Khanit Suwanborirux, Masashi Yokoya, Naoki Saito
    • Journal Title

      Tetrahedron

      Volume: 68 Issue: 36 Pages: 7422-7428

    • DOI

      10.1016/j.tet.2012.06.067

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Chemistry of renieramycins. Part 13. Isolation and structure of stabilized renieramycin type derivatives, renieramycins W-Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide2012

    • Author(s)
      Tatsukawa M., Punzalan LL., Magpantay H. D. S., Villasenor I. M., Concepcion G. P., Suwanborirux K., Yokoya M., Saito N.
    • Journal Title

      Tetrahedron

      Volume: 68 Pages: 7422-7428

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Chemistry of renieramycins. Part 12. An inproved total synthesis of (;/-)-renieramycin G2012

    • Author(s)
      Yokoya M., Shinada-Fujino K., Yoshida S., Mimura M., Takada H., Saito N.
    • Journal Title

      Tetrahedron

      Volume: 68 Pages: 4166-4181

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Molecular networkprofiling of U373MG human glioblastomacells following induction of apoptosis bynovel marine-derived anti-cancer1,2,3,4-tetrahydroisoquinoline alkaloids.2012

    • Author(s)
      Tabunoki H, Saito N, Suwanborirux K,Charupant K, Satoh J.
    • Journal Title

      Cancer Cell International

      Volume: 12(1) Issue: 1 Pages: 1-14

    • DOI

      10.1186/1475-2867-12-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500322, KAKENHI-PROJECT-23590019
  • [Journal Article] Selenium oxide oxidation of hexahydro-1,5-imino-3-benzazocine-7,10-dione in aliphatic alcohol for conversion of renieramycin marine natural product2012

    • Author(s)
      Mori M., Daikuhara N., Yamada J., Saito N.
    • Journal Title

      Heterocycles

      Volume: 86 Issue: 1 Pages: 317-330

    • DOI

      10.3987/com-12-s(n)12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Molecular network profiling of U373MG human glioblastoma cells-following induction of apoptosis by novel marine derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids2012

    • Author(s)
      Tabunoki H., Saito N., Suwanborirux K., Charupant K., Satoh J.
    • Journal Title

      Cncer Cell International

      Volume: 12/14 Pages: 1-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Synthesis of Renieramycins. Construction of the Core Ring System of Cribrostatin 4 Trough Modified Pictet-Spengler Cyclization of 3,6-Bisarylpiperazine-2,5-Dione with Diethoxyethyl Benzoate2011

    • Author(s)
      Masashi Yokoya, Hiroshi Ito, Naoki Saito
    • Journal Title

      Chem. Pharm. Bull

      Volume: 59 Pages: 787-792

    • URL

      https://www.jstage.jst.go.jp/article/cpb/59/6/59_6_787/_pdf

    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Synthesis of renieramycins: construction of2011

    • Author(s)
      Yokoya M., Ito H., Saito N.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 59 Pages: 787-792

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Chemistry of Renieramycins. Part 11. Total Synthesis of (±)-Cribrostatin 42011

    • Author(s)
      Masashi Yokoya, Hiroshi Ito, Naoki Saito
    • Journal Title

      Tetrahedron

      Volume: 67 Issue: 47 Pages: 9185-9192

    • DOI

      10.1016/j.tet.2011.09.076

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Chemistry of Ecteinascidins. Part 3. Preparation of 2'-N-Acyl Derivatives of Ecteinascidin 770 and Evaluation of Cytotoxicity2011

    • Author(s)
      Panithi Saktrakulkula, Satoru Toriumi, Masahiro Tsujimoto, Chamunan Patarapanich, Khanit Suwanborirux, Naoki Saito
    • Journal Title

      Bioorg. & Med. Chem

      Volume: 19 Pages: 4421-4436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Chemistry of renieramycins. Part 9: Stereo-2011

    • Author(s)
      Yokoya M., Shinada-Fujino K., Saito N.
    • Journal Title

      Tetrahedron Letters

      Volume: 52 Pages: 2446-2449

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Chemistry of Renieramycins. Part 9. Stereocontrolled Total Synthesis of (±)-Renieramycin G2011

    • Author(s)
      Masashi Yokoya, Kimiko Shinada-Fujino, Naoki Saito
    • Journal Title

      Tetrahedron Lett

      Volume: 52 Pages: 2446-2449

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Journal Article] Structure and chemical property of three new marine alkaloids from the nudibranch Jorunna funebris which lives through in the blue sponge2005

    • Author(s)
      Naoki Saito, et al.
    • Journal Title

      Yakugaku Zasshi 125, Suppl.3

      Pages: 262-265

    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Chemistry of Renieramycins. Part 6. Transformation of Renieramycin M into Jorumycin and Renieramycin J including Oxidative Degradation Products, Mimosamycin, Renierone, and Renierol Acetate2004

    • Author(s)
      Saito, N., Tanaka, C., Koizumi, Y., Suwanborirux, K., Amnuoypol S., Kubo, A.
    • Journal Title

      Tetrahedron 60(17)

      Pages: 3873-3881

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Chemistry of Renieramycins. Part 6 : Transformation of Renieramycin M into Jorumycin J including Oxidative Degradation Products, Mimosamycin, Renierone, and Renierol Acetate2004

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Tetrahedron 60

      Pages: 3873-3881

    • Data Source
      KAKENHI-PROJECT-14370725
  • [Journal Article] Chemistry of Renieramycins. Part 4. Synthesis of a Simple Natural Marine Product, 6-Hydroxy-7-methoxy-isoquinolinemethanol2004

    • Author(s)
      Saito, N., Tanaka, C., Satomi, T., Oyama, C., Kubo, A.
    • Journal Title

      Chem.Pharm.Bull. 52(2)

      Pages: 282-286

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Chemistry oRenieramycins. Part 4. Synthesis of a Simple Natural Marine Product, 6-Hydroxy-7-methoxyisoquinolinemethanol2004

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Chem.Pharm.Bull. 52(2)

      Pages: 282-286

    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Chemistry of Renieramycins. Part 5. Structure Elucidation of Renieramycin Type Derivatives O, Q, R, and S from Thai Marne Sponge Xestospoigia Species Pretreated with Potassium Cyanide2004

    • Author(s)
      Amnuoypol S., Suwanborirux, K., Pummangura, S., Kubo, A., Tanaka, C., Saito, N.
    • Journal Title

      J.Nat.Prod. 67(6)

      Pages: 1023-1028

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Chemistry of Renieramycins. Part 6 : Transformation of Renieramycin M into Jorumycin and Renieramycin J including Oxidative Degradation Products, Mimosamycin, Renierone, and Renierol Acetate2004

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Tetrahedron 60

      Pages: 3873-3881

    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Cheniistry of Renieramycins. Part 4. Synthesis of a simple Natural Marine Product, 6-Hydroxy-7-methoxyisoquinoline methanol2004

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Chem. Pharm. Bull. 52 (2)

      Pages: 282-286

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Chemistry of Renieramycins. Part 6. Transformation of Renieramycin M into Jorumycin and Renieramycin J including Oxidative Degradation Products, Mimosamycin, Renierone, and Renierol Acetate2004

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Tetrahedron 60 (17)

      Pages: 3873-3881

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Synthesis of a Simple Natural Marine Product, 6-Hydroxy-7-methoxyisoquino linemethanol2004

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Chem.Pharm.Bull. 52

      Pages: 282-286

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370725
  • [Journal Article] Synthesis of a Simple Natural Marine Product, 6-Hydroxy-7-methoxyisoquinolinemethanol2004

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Chem.Pharm.Bull. 52

      Pages: 282-286

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370725
  • [Journal Article] Chemistry of Antitumor Isoquinoline Alkaloids : Unexpected Oxidation of Saframycin S to Generate Simple Isoquinoline Alkaloids, Mimosamycin and Momocin2003

    • Author(s)
      Saito, N., Koizumi, Y., Suwanborirux, K., Kubo, A.
    • Journal Title

      Heterocycles 61(1)

      Pages: 79-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Chemistry of Renieramycins. Part 3. Isolation of Stabilized Renieramycin Type Derivatives Possessing Activity from Thai Sponge, Xestospoigia Species Pretreated with Potassium Cyanide2003

    • Author(s)
      Suwanborirux, K., Amnuoypol S., Plubrukarn, A., Pummangura, S., Kubo, A., Saito, N.
    • Journal Title

      J.Nat.Prod. 66(11)

      Pages: 1441-1446

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Synthetic Approaches toward Ecteinascidins. Part 2. Preparation of the ABCDE Ring System of Ecteinascidins having Characteristic Substituents in Both Benzene Rings2003

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Chem.Pharm.Bull. 51

      Pages: 821-831

    • NAID

      110003615402

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370725
  • [Journal Article] Synthetic Approaches toward Ecteinascidins. Part 2. Preparation of the ABCDE Ring System of Ecieinascidins having Characteristic Substituents in Both Benzene Rings2003

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Chem.Pharm.Bull. 51

      Pages: 821-831

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370725
  • [Journal Article] Chemistry of Antitumor Isoquinoline Alkaloids. Unexpected Oxidation of Saframycin S to Generate Simple Isoquinoline Alkaloids, Mimocin and Mimosamycin2003

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Heterocycles 61 (1)

      Pages: 79-86

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] A Practical Synthesis of the ABC Ring of Ecteinascidins2000

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Chem.Pharm.Bull. 48

      Pages: 1549-1557

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370725
  • [Journal Article] A Practical Synthesis of the ABC Ring Model of Ecteinascidins2000

    • Author(s)
      Naoki Saito et al.
    • Journal Title

      Chem.Pharm.Bull. 48

      Pages: 1549-1557

    • NAID

      110003635326

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370725
  • [Journal Article] Jorunnamycins A-C, Novel Cytotoxic Renieramycin Type Bistetrahydroisoquinolines isolate from the Thai Nudibranch Jorunna funebris

    • Author(s)
      Charupant K., Kuwanborirux K., Amnuoypol, S., Saito, E., Kubo, A., Saito, N.
    • Journal Title

      J.Nat.Prod. (submitted)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Journal Article] Renieramycins, their isolation from Xestospongia species, and anticancer agents containing them.

    • Author(s)
      Kubo, A., Saito, N., Pummangura, S., Suwanborirux, K.
    • Journal Title

      Jpn.Kokai Tokkyo Koho, JP 2004231552 A2 20040819(Priority Application : JP 2003-20821

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Patent] 新規レニエラマイシン系化合物、その取得方法およびその用途2003

    • Inventor(s)
      久保陽徳, 齋藤直樹, スニポーン・プマングーラ, カニ・スワンボリラック
    • Industrial Property Rights Holder
      久保陽徳
    • Filing Date
      2003-01-29
    • Acquisition Date
      2004-08-19
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590019
  • [Presentation] アルコキシ-p-キノンに対する光環化反応2019

    • Author(s)
      横屋正志、望月萌、松原健治、Natchanun Sirimangkalakitti、齋藤直樹
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] Ecteinascidin類のE環部構築手段の開発2019

    • Author(s)
      佐藤凌、横屋正志、齋藤直樹
    • Organizer
      第63回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] 新規微量海洋天然物レニエラマイシンYの合成アプローチ2019

    • Author(s)
      小林翔、横屋正志、丸山崚、齋藤直樹
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] Chemistry of antitumor isoquinoline marine natural products and related compounds2019

    • Author(s)
      Saito N
    • Organizer
      35th International Annual Meeting in Thai Pharmaceutical Sciences
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] エクチナサイジン海洋天然物の特徴的なフェノール置換様式の構築2019

    • Author(s)
      佐藤凌、横屋正志、齋藤直樹
    • Organizer
      第45回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] 海洋天然物renieramycin Tの合成研究2019

    • Author(s)
      野田大樹、横屋正志、齋藤直樹
    • Organizer
      第63回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] 抗腫瘍活性イソキノリン海洋天然物および関連化合物の化学的研究2019

    • Author(s)
      齋藤直樹
    • Organizer
      日本薬学会第139年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] Structure-cytotoxicity relationship studies of bis-1,2,3,4-tetrahydroisoquinoline alkaloids as promising anticancer agents2019

    • Author(s)
      Sirimangkalakitti N., Yokoya M., Chamni S., Suwanborirux K., Saito N.
    • Organizer
      20th Tetrahedron Symposium (Received poster-presentation award)
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] Chemistry of antitumor isoquinoline marine natural products and related compounds2019

    • Author(s)
      Saito N.
    • Organizer
      35th International Annual Meeting in Pharmaceutical Sciences
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] 抗腫瘍活性レニエラマイシン海洋天然物の右半部モデルの合成と生物活性に関する研究2019

    • Author(s)
      松原健宏、Sirimangkalakitti Nachanun, 横屋正志、齋藤直樹
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] 抗腫瘍活性レニエラマイシン海洋天然物の右半部モデルの合成と生物活性に関する研究2019

    • Author(s)
      松原健治、Natchanun Sirimangkalakitti、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] アルコキシ-p-キノンに対する光環化反応2019

    • Author(s)
      横屋正志、望月萌、松原健宏、Sirimangukalakitti Natchanun, Suwanborirux Khanot, 齋藤直樹
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] 抗腫瘍活性イソキノリン海洋天然物および関連化合物の化学的研究(2019年度日本薬学会学術貢献賞受賞講演)2019

    • Author(s)
      齋藤直樹
    • Organizer
      日本薬学会第139年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] 抗腫瘍活性を有するテトラヒドロイソキノリン系天然物の合成研究2018

    • Author(s)
      木村真也、齋藤直樹
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 新規極微量海洋天然物レニエラマイシンYの合成アプローチ2018

    • Author(s)
      小林 翔、横屋正志、丸山 崚、齋藤直樹
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] レニエラマイシン海洋アルカロイドの前駆体として想定されるレニエラマイシンYの合成研究2018

    • Author(s)
      小林翔、横屋正志、丸山崚、齋藤直樹
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] 含窒素複素環キノンに対する新規光反応の開発2018

    • Author(s)
      望月 萌、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] A versatile synthesis of renieramycin narine natural products2018

    • Author(s)
      Yokoya M., Sato M., Monden K., Kobayashi K., Saito N.
    • Organizer
      International congress on Pure & Applied Chemistry
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] Renieramycin類の光学活性CDE環モデルの合成2018

    • Author(s)
      松原健治、横屋正志、Nachanun Sirimangkalakitti、齋藤直樹
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 生物活性イソキノリン抗生物質を基軸とする新規認知症改善薬の創製2018

    • Author(s)
      Nachanun Sirimangkalakitti、中井啓陽、山﨑未来、紀嘉浩、佐藤準一,、齋藤直樹
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] Renieramycin類の光学活性CDE環境モデルの合成研究2018

    • Author(s)
      松原健浩、横屋正志、Natchanun Sirimangkalakitti Natchanun, 齋藤直樹
    • Organizer
      第62回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-18K06561
  • [Presentation] 新規極微量海洋天然物7-demethylrenieramycin Oと誘導体の合成研究2018

    • Author(s)
      門傅研人、横屋正志、佐藤充浩、小林恵一郎、齋藤直樹
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 1.3-ジオキサシクロペンタン環を生じる新規光反応前駆体の柔軟な合成法の開発2018

    • Author(s)
      高橋昇平、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 強力な抗腫瘍活性を有するビステロラヒドロイソキノリン天然物の合成研究2017

    • Author(s)
      木村真也、齋藤直樹
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] Renieramycin類の光学活性CDE環モデルの合成2017

    • Author(s)
      松原健治、横屋正志、齋藤直樹
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 生物活性新規イソキノリンアルカロイドFennebricin A及びBの全合成研究2017

    • Author(s)
      門傅 研人、横屋 正志、佐藤 充浩、小林 恵一郎、齋藤 直樹
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] Chemistry of biologically active natural 1,2,3,4-tertahydroisoquinoline: Unpredictable photochemical transformation of renieramycin type p-quinone into ecteinscidin type phenol2017

    • Author(s)
      Saito N., Nakai K., Yamazaki M., Yokoya M.
    • Organizer
      26th International synposium of heterocyclic chemistry (ISHC) congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 相関移動触媒を用いた光学活性チロシン誘導体の合成2017

    • Author(s)
      安齋 凌、横屋正志、齋藤直樹
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 光変換反応を利用した1,3-ジオキサシクロペンタン環の形成2017

    • Author(s)
      高橋 昌平、横屋 正志、山﨑 未来、齋藤 直樹
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 強力な抗腫瘍活性を有するビステトラヒドロイソキノリン系天然物の合成研究2017

    • Author(s)
      木村 真也、齋藤 直樹
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] Succcessful international collaborative medicinal chemistry of biologically active marine natural products based on Thai marine oranagisms2017

    • Author(s)
      Saito N
    • Organizer
      The JSPS-NRCT follow-up seminar 2017 and 33rd international annual meeting in Pharmaceutical Sciences
    • Place of Presentation
      バークレーホテル(バンコク)
    • Year and Date
      2017-03-02
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 抗腫瘍活性イソキノリン系天然物の化学的展開と創薬リードの創製2017

    • Author(s)
      横屋正志、Nachanun Sirimangkalakitti、Supakarn Chamni、望月 萌、鈴木俊宏、齋藤直樹
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 海洋天然物7-デメチルレニエラマイシンOの全合成及びフェネブリシン類の合成2017

    • Author(s)
      門傅研人、佐藤充浩、小林恵一郎、横屋正志、齋藤直樹
    • Organizer
      第74回有機合成化学協会関東支部シンポジウム
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 新規海洋天然物レニエラマイシンYの合成研究2016

    • Author(s)
      丸山 崚、横屋 正志、齋藤 直樹
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      清水市清水文化会館(静岡)
    • Year and Date
      2016-11-06
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] Chemistry of antitumor isoquinoline marine natural products: Total synthesisi of (-)-renieramycin T2016

    • Author(s)
      Saito N.
    • Organizer
      3rd Symposium of Showa Pharmaceutical University (SPU) innovative pharmaceutical analysis of covalent modification in biomolecules
    • Place of Presentation
      昭和薬科大学(東京)
    • Year and Date
      2016-08-31
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 抗腫瘍活性微量天然物レニエラマイシンTの不斉全合成2015

    • Author(s)
      t豊嶋涼子、横屋正志、齋藤直樹、Le. H. V., Williams R. M.
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-26
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] レニエラマイシン系海洋天然物のキラル合成アプローチ2015

    • Author(s)
      豊嶋涼子、横屋正志、齋藤直樹
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] Synthetic studies on a total synthesis of antitumor renieramycin T2015

    • Author(s)
      Yokoya M., Toyoshima R., Saito N., Le V. H., Williams R. M.
    • Organizer
      25th International Symposium of Heterocyclic Chemistry
    • Place of Presentation
      California (USA)
    • Year and Date
      2015-08-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 海洋天然物クリブロスタチン4の改良合成およびレニエラマイシンIの全合成2015

    • Author(s)
      佐藤充浩、小林恵一郎、横屋正志、齋藤直樹
    • Organizer
      第70回記念有機合成化学協会関東支部シンポジウム
    • Place of Presentation
      長岡
    • Year and Date
      2015-11-21
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] 抗腫瘍活性エクチナサイジン海洋天然物の合成と生物活性2015

    • Author(s)
      森ななえ、豊嶋涼子、藤野晃也、鈴木俊宏、横屋正志、齋藤直樹、Khanit Suwanborirux
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-15K07873
  • [Presentation] レニエラマイシンMの右半部モデル化合物の合成と生物活性評価2014

    • Author(s)
      中井啓陽、久保佳司、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 海洋天然物クリブロスタチン4の基本骨格形成反応の機構会計に向けた化学的研究2014

    • Author(s)
      小林恵一郎、伊東裕史、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] レニエラマイシン系海洋天然物の探索研究:期限海洋生物の生息地と二次代謝産物の比較2014

    • Author(s)
      平出裕美、平松亜依、Louvy L. C. Punzalan, Gisela P. Concepcion, Natchanun Sirimankalakitti, Khanit Suwanborirux, 齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] エクチナサイジン海洋天然物の化学修飾と生物活性評価2014

    • Author(s)
      森ななえ、辻本光宏、Witaya Lowtangkitcharoen, Khanit Suwanborirux, 齋藤直樹
    • Organizer
      日本薬学会第134 年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-29
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] エクチナサイジン海洋天然物の化学的研究:天然物の化学修飾と生物活性評価2014

    • Author(s)
      森ななえ、辻本光宏、Witaya Lowtangkitcharoen, Khanit Suwanborirux, 齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] サフラマイシンAの合成(その2)2014

    • Author(s)
      河合慎太郎、東雅之、木村真也、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] レニエラマイシン右半部モデル化合物の合成と生物活性評価2014

    • Author(s)
      中井啓陽、久保圭司、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第134 年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-28
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 新規抗腫瘍活性海洋天然物レニエラマイシンTの全合成研究(22014

    • Author(s)
      木村真也、齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] タイ国に生息する群体ホヤ由来エクチナサイジン海洋天然物の抗腫瘍活性増強を目指した合成研究2013

    • Author(s)
      森ななえ、辻本光宏、ビタヤ・ロタンチャローン、カニ・スワンボリラックス、齋藤直樹
    • Organizer
      第3回CSJ化学フェスタ
    • Place of Presentation
      船堀(東京)
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 抗腫瘍活性天然物レニエラマイシンM の全合成2013

    • Author(s)
      高田裕樹、三村政博、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-29
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] タイの群体ホヤ由来1,2,3,4-テトラヒドロイソキノリン海洋天然物の単利・構造決定および合成2013

    • Author(s)
      木村真也、Waree Pangkruang, 横屋正志、本田遍、Ploenthip Puthongking, Khanit Suwanborirux, 齋藤直樹
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      帝京大学薬学部(東京)
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 1,2,3,4-テトラヒドロイソキノリンのアセチル化に対する挙動2013

    • Author(s)
      中井啓陽、木村真也、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] サフラマイシンAの全合成アプローチ2013

    • Author(s)
      河合慎太郎、東雅之、木村真也、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] Chemistry of Ecteinascidin Marine Natural Products: Preparation of 2'-N-Acyl Derivative of Ecteinascidin 770 and Evaluation of Cytotoxicity2013

    • Author(s)
      Saito N., Tsujimoto M., Mori N., Pangkruang W., Puthongking P., Loutangkitcharoen W., Suwanborirux K.
    • Organizer
      The 9th AFMC International Medicinal Chemistry Symposium (ALMECS13)
    • Place of Presentation
      台湾(中華民国)
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 抗腫瘍活性海洋天然物レニエラマイシンMの全合成2013

    • Author(s)
      高田裕樹、三村政博、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] エクチナサイジン770誘導体の合成と生物活性2013

    • Author(s)
      辻本光宏、森ななえ、齋藤直樹、L. Witaya, K. Suwanborirux
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 海洋生物由来新規テトラハイドロイソキノリンアルカロイドによるヒトグリオーマ細胞に対するアポトーシス誘導機序の分子ネットワーク解析2013

    • Author(s)
      天竺桂弘子、島村悦光、野島陽水、川名夏生、K. Suwanborirux, K. Charupant, 齋藤直樹、佐藤準一
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] タイ国に生息する海洋生物由来アルカロイドを創薬リードとする化学的研究2013

    • Author(s)
      齋藤直樹
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] タイ国に生息する海洋生物由来アルカロイドを創薬リードとする化学的研究2013

    • Author(s)
      齋藤直樹
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      帝京大学薬学部(東京)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 抗腫瘍活性テトラヒドロイソキノリン天然物の合成―共通中間体から左半部モデル化合物の合成2013

    • Author(s)
      中井啓陽、久保圭司、中山梨乃、横屋正志、齋藤直樹
    • Organizer
      第39回反応と合成の進歩シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2013-11-05
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 新規微量海洋天然物レニエラマイシンTの全合成研究:基本骨格の構築2013

    • Author(s)
      木村真也、齋藤直樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] Chemistry of Ecteinascidin Marine Natural Products. Preparation of 2'-N-Acyl Derivatives of Ecteinascidin 770 and Evaluation of Cytotoxicity2013

    • Author(s)
      Naoki Saito, Mitsuhiko Tsujimoto, Nanae Mori, Waree Pangkruang, Proenthip Puthongking, Witaya Lowtangkitcharoen, Khanit Suwanborirux
    • Organizer
      The 9^<th> FMC International Chemistry Symposium (AIMECS13)
    • Place of Presentation
      Taipei (Taiwan)
    • Year and Date
      2013-10-17
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 抗腫瘍活性テトラヒドロイソキノリン天然物の合成ー共通中間体から左半部モデル化合物の合成2013

    • Author(s)
      中井啓陽、久保佳司、中山梨乃、横屋正志、齋藤直樹
    • Organizer
      第39回反応と合成の進歩シンポジウム
    • Place of Presentation
      九州大学(博多)
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] Chemistry of Renieramycin Antitumor Marine Natural Products. An Improved Total Synthesis of (±)-Renieramycin G2012

    • Author(s)
      Naoki Saito, Kimiko Shinada-Fujuno, Masashi Yokoya
    • Organizer
      15^<th> tetrahedron Symposium
    • Place of Presentation
      Amsterdam (the Netherlands)
    • Year and Date
      2012-06-27
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] Chemistry of renieramycin antitumor marine natural products. An improved total synthesis of (+/-)-renieramycin G2012

    • Author(s)
      Saito N., Shinada-Fujino K., Yokoya M.
    • Organizer
      13th Tetrahedron Symposium
    • Place of Presentation
      アムステルダム
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] フィリピンに生息する青色海綿由来天然物の構造2012

    • Author(s)
      辰川真理、平出裕美、齋藤直樹、Hirbert D. S. Magpantay, Louvy L. C. Punzalan, Gisela P. Concepcion
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 青色海綿由来イソキノリン海洋天然物の全合成研究2012

    • Author(s)
      横屋正志、伊藤裕史、齋藤直樹
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2012-11-07
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] 海洋天然物エクチナサイジンを新規制がん剤の創薬シードとする化学的研究2012

    • Author(s)
      鳥海悟、辻本光宏、Panithi Saktrakulkla, Chamnan Patarapanich, Khanit Suwanborirux, 齋藤直樹
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] レニエラマイシンGの改良合成:工程数の短縮2012

    • Author(s)
      高田裕樹、横屋正志、三村正博、齋藤直樹
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] レニエラマイシン海洋天然物の化学的研究:右半部モデルの二酸化セレン酸化による5位への酸素官能基の立体選択的導入2012

    • Author(s)
      森麻悠子、大工原直美、齋藤直樹
    • Organizer
      第38回反応と合成の進歩シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] レニエラマイシン海洋天然物の化学的研究:右半部モデルの二酸化セレン酸化による5位への酸素官能基の立体選択的導入2012

    • Author(s)
      森麻悠子、大工原直美、齋藤直樹
    • Organizer
      第38回反応と合成の進歩シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-11-05
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] フィルピンに生息する青色海綿が生産する新規レニエラマイシン海洋天然物の構造2012

    • Author(s)
      辰川真理、平出裕美、横屋正志、Louvy L. C. Punzalan, Hirbert D. S. Magpantay, Gisela P. Concepcion, 齋藤直樹
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] Chemistry of Ecteinascidin Marine Natural Products: Synthesis of 6'-O- and 2'-N-Acyl Derivatives of Ecteinascidin 770 for Evaluation of Cytotoxicity2011

    • Author(s)
      Naoki Saito, Satoru Toriumu, Mitsuhiro Tsujimoto, Panithi Saktrakulkla, Khanit Suwanborirux
    • Organizer
      8^<th> FMC International Chemistry Symposium (AIMECS11)
    • Place of Presentation
      Tokyo (Japan)
    • Year and Date
      2011-12-02
    • Data Source
      KAKENHI-PROJECT-23590019
  • [Presentation] Chemistry of Ecteinascidin Marine Natural2011

    • Author(s)
      Saito N.
    • Organizer
      8th AFMC Internat. Med. Chem. Sympo.
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-23590019
  • 1.  KUBO Akinori (60097201)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  KITAHARA Yoshiyasu (70114460)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  NAKAHARA Akinori (60180337)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  木村 真也 (10632739)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 5.  YOKOYA Masashi (50338539)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 28 results
  • 6.  TAKAYAMA Hiromitu (90171561)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  AIMI Norio (30009170)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MIKAMI Yuzuru (40092100)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NAKAI Tatuya (80217645)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  坂井 進一郎 (20009161)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  佐藤 準一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  天竺桂 弘子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi