ISHIMI Yukio 石見幸男

Researcher Number	80159772
Other IDs
Affiliation (based on the past Project Information) *help	2018: 茨城大学, 理工学研究科(理学野), 教授 2011 – 2017: 茨城大学, 理学部, 教授 2005 – 2009: 茨城大学, 理学部, 教授
Review Section/Research Field	Principal Investigator Molecular biology Except Principal Investigator Eating habits / Biological Sciences
Keywords	Principal Investigator DNAヘリカーゼ / タンパク質相互作用 / DNA複製フォーク / タンパク質リン酸化 / 細胞周期 / MCMタンパク質 / DNA複製 / タンパク質集合 / ヘリカーゼ / MCM2-7機能発現制御 … More / HIF-１A / MCM4/6/7複合体 / 細胞がん化 / MCM4変異 / CDKによるリン酸化 / DNA複製制御 / MCM2-7複合体 / MCMヘリカーゼ活性 / ゲノム / 酵素 / タンパク質 / MCMヘリカーゼ / サイクリン依存性キナーゼ / 分子生物学 / 一本鎖DNA結合活性 / タンパク質ドメイン / 一本鎖DNA結合 / ATP分解 / DNA複製阻害 / チェックポイント / 抗生物質 … More Except Principal Investigator 脂肪細胞 / 細胞分化 / 細胞増殖 / 乳がん細胞 / 大豆イソフラボン / DNA複製 / 細胞周期 / オートファジー / 骨芽細胞 / 自食作用 / 植物性エストロゲン / ＤＮＡ二本鎖切断 / DNA二本鎖切断 / 血管内皮細胞 / エクオール / 血流 / 体脂肪 / 骨密度 / 有効性評価 / 安全性評価 / フィトケミカル / 微生物 / 蛋白質 / ゲノム / 核酸 / 遺伝学 / 複製チェッポイント / クロマチン構造 / 複製チェックポイント / 複製開始点 / リン酸化制御 / ヘテロクロマチン / 複製開始複合体 / 分裂酵母 / MCMヘリカーゼ / テロメア / セントロメア / クロマチン / 染色体 Less

Role of autophagy on cell growth and differenciation by phytoestorogens
- Principal Investigator
  
  ISHIMI YOSHIKO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Mechanisms of assembly and inhibition of DNA replication factors including MCM proteinsPrincipal Investigator
- Principal Investigator
  
  Ishimi Yukio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Ibaraki University
Assessment of efficacy and safety of isoflavone metabolite
- Principal Investigator
  
  Ishimi Yoshiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
  National Institute of Health and Nutrition
Protein assembly at DNA replication fork and role of replication DNA helicasePrincipal Investigator
- Principal Investigator
  
  ISHIMI Yukio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Ibaraki University
Studies on molecular assembly of replication proteins and regulation of their functions in initiation of chromosome DNA replication
- Principal Investigator
  
  MASUKATA Hisao
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Elucidation of mechanisms of MCM helicase functionPrincipal Investigator
- Principal Investigator
  
  ISHIMI Yukio
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Ibaraki University

[Book] すべての診療科で役立つ栄養学と食事・栄養療法2019
- Author(s)
  石見佳子
- Total Pages
  247
- Publisher
  羊土社
- ISBN
  9784758108980
- Data Source
  KAKENHI-PROJECT-16K00902
[Book] 食品機能性成分の吸収・代謝・作用機序2018
- Author(s)
  石見佳子
- Total Pages
  316
- Publisher
  シーエムシー出版
- ISBN
  9784781313276
- Data Source
  KAKENHI-PROJECT-16K00902
[Book] 食と微生物の事典2017
- Author(s)
  石見佳子他
- Total Pages
  490
- Publisher
  朝倉書店
- ISBN
  9784254431216
- Data Source
  KAKENHI-PROJECT-16K00902
[Book] 大豆イソフラボンの有用性と安全性2015
- Author(s)
  石見佳子
- Total Pages
  26
- Publisher
  建帛社
- Data Source
  KAKENHI-PROJECT-25350178
[Book] Association between exercise and diet on maintaining bone health in postmenopausal women and female athletes2015
- Author(s)
  Ishimi Y, Yanaka K, Higuchi M
- Total Pages
  18
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25350178
[Book] Binding of human MCM-BP with MCM2-7 proteins. in DNA replication-current advances2011
- Author(s)
  Kon, R., Kusunoki, S., Nozaki, N. and Ishimi, Y.
- Publisher
  In Tech.
- Data Source
  KAKENHI-PROJECT-23570204
[Book] 染色体サイクル(複製開始と進行におけるMCMタンパク質複合体)2009
- Author(s)
  石見幸男
- Total Pages
  6
- Publisher
  蛋白質核酸酵素(共立出版)
- Data Source
  KAKENHI-PROJECT-17370059
[Book] 複製開始と進行におけるMCMタンパク質複合体(染色体サイクル(正井、升方、釣本、仁木、篠原編)蛋白質核酸酵素2009
- Author(s)
  石見幸男
- Data Source
  KAKENHI-PROJECT-17370059
[Book] 細胞周期集中マスター(DNA複製開始とその制御機構)(北川雅俊編)2006
- Author(s)
  石見幸男
- Total Pages
  154
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17080003
[Book] DNA複製開始とその制御機構(細胞周期集中マスター(北川雅敏編))2006
- Author(s)
  石見幸男
- Total Pages
  12
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17370059
[Book] DNA複製開始とその制御機構(細胞周期集中マスター(北川編)実験医学2006
- Author(s)
  石見幸男
- Data Source
  KAKENHI-PROJECT-17370059
[Book] MCMタンパク質複合体の機能制御(細胞周期の最前線(中山編)実験医学2005
- Author(s)
  石見幸男
- Data Source
  KAKENHI-PROJECT-17370059
[Book] 細胞周期の最前線(実験医学増刊、中山敬一編)2005
- Author(s)
  石見幸男
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17370059
[Journal Article] Resistant starch attenuates bone Loss in ovariectomised mice by regulating the intestinal microbiota and bone-marrow inflammation.2019
- Author(s)
  Tousen Y, Matsumoto Y, Nagahata Y, Kobayashi I, Inoue M, Ishimi Y.
- Journal Title
  
  Nutrients.
  
  Volume: 11(2) Issue: 2 Pages: 297-297
- DOI
  10.3390/nu11020297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00901, KAKENHI-PROJECT-16K00902, KAKENHI-PROJECT-19K11786
[Journal Article] Comparison of Nutrient Reference Values for Food Labeling in Japan with CODEX Recommendations, Based on DRIs and Nutrient Intake in Japan2019
- Author(s)
  Tsuboyama-Kasaoka N, Takimoto H, Ishimi Y.
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: 65 Issue: 1 Pages: 102-105
- DOI
  10.3177/jnsv.65.102
- NAID
  130007604899
- ISSN
  0301-4800, 1881-7742
- Year and Date
  2019-02-28
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K00902
[Journal Article] β-Carotene prevents bone loss in hind limb unloading mice2018
- Author(s)
  Matsumoto Yu, Tousen Y and Ishimi Y.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 63 Issue: 1 Pages: 42-49
- DOI
  10.3164/jcbn.17-86
- NAID
  130007387114
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00901, KAKENHI-PROJECT-16K00902
[Journal Article] Isoflavones and green kiwifruit: A pilot study assessing the effects on equol production, bone turnover and gut microflora in healthy postmenopausal New Zealand women.2018
- Author(s)
  Kruger MC, Middlemiss C, Katsumata S, Tousen Y, Ishimi Y
- Journal Title
  
  Asia Pac J Clin Nutr
  
  Volume: 27 Pages: 347-358
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00902
[Journal Article] Effect of daidzein and equol on DNA replication in MCF-7 cells2018
- Author(s)
  Tsuji Mako、Tanaka Tomoki、Nagashima Ryosuke、Sagisaka Yuka、Tousen Yuko、Nishide Yoriko、Ishimi Yoshiko、Ishimi Yukio
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 163 Issue: 5 Pages: 371-380
- DOI
  10.1093/jb/mvy006
- NAID
  40021555315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K00902, KAKENHI-PROJECT-16K00901
[Journal Article] An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation2017
- Author(s)
  Tatsumi, R. and Ishimi, Y.
- Journal Title
  
  J. Biochem.
  
  Volume: 161 Pages: 259-268
- DOI
  10.1093/jb/mvw065
- NAID
  40021162046
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440002
[Journal Article] Combined effects of soy isoflavones and milk basic protein on bone mineral density in hind-limb unloaded mice2016
- Author(s)
  Matsumoto Y, Tousen Y, Nishide Y, Tadashi M, Kato K, Ishimi Y
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 58 Issue: 2 Pages: 141-145
- DOI
  10.3164/jcbn.14-137
- NAID
  130005132518
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350178, KAKENHI-PROJECT-26750062, KAKENHI-PROJECT-16K00901, KAKENHI-PROJECT-16K00902
[Journal Article] Combined Effects of Soy Isoflavones and Docosahexaenoic Acid on Osteoclast Formation.2016
- Author(s)
  Katsumata S、Plimmer G、Tadaishi M、Tousen Y、Ishimi Y、Kruger MC
- Journal Title
  
  Journal of Food and Nutrition Research
  
  Volume: 4 Pages: 429-435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K00902
[Journal Article] Binding of MCM-interacting proteins to ATP-binding site in MCM62016
- Author(s)
  Hosoi A., Sakairi T. and Ishimi Y.
- Journal Title
  
  Research and Reports in Biology
  
  Volume: 7 Pages: 31-40
- DOI
  10.2147/rrb.s96215
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440002
[Journal Article] The combined effects of soya isoflavones and resistant starch on equol production and trabecular bone loss in ovariectomised mice.2016
- Author(s)
  Tousen Y, Matsumoto Y, Matsumoto C, Nishide Y, Nagahata Y, Kobayashi I, Ishimi Y
- Journal Title
  
  Br J Nutr.
  
  Volume: 116(2) Issue: 2 Pages: 247-57
- DOI
  10.1017/s0007114516001537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K00901, KAKENHI-PROJECT-16K00902
[Journal Article] Assessment of safety and efficacy of perinatal or lifelong exposure to daidzein on bone development in rats2015
- Author(s)
  Tousen Y, Ishiwata H, Takeda K, Ishimi Y.
- Journal Title
  
  Toxicology Rep
  
  Volume: Epub ahead of print
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25350178
[Journal Article] Osteoporosis and Lifestyle2015
- Author(s)
  Ishimi Y
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: 61 Issue: Supplement Pages: S139-S141
- DOI
  10.3177/jnsv.61.S139
- NAID
  130005109885
- ISSN
  0301-4800, 1881-7742
- Language
  English
- Data Source
  KAKENHI-PROJECT-25350178
[Journal Article] G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex2015
- Author(s)
  Ishimi, Y. and Irie, D.
- Journal Title
  
  J. Biochem.
  
  Volume: 未定 Issue: 6 Pages: 561-569
- DOI
  10.1093/jb/mvv015
- NAID
  40020489288
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440002
[Journal Article] Equol, a metabolite of daidzein, is more efficient than daidzein for bone formation in growing female rats2015
- Author(s)
  Tousen Y, Ishiwata H, Ishimi Y, Ikegami S
- Journal Title
  
  Phytotherapy Research
  
  Volume: 29(9) Issue: 9 Pages: 1349-1354
- DOI
  10.1002/ptr.5387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350178, KAKENHI-PROJECT-26750062
[Journal Article] Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-72014
- Author(s)
  Kusunoki, S. and Ishimi, Y.
- Journal Title
  
  F EBS J.
  
  Volume: 281 Pages: 1057-1067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570204
[Journal Article] 食品中の大豆イソフラボン組成と生体利用性2014
- Author(s)
  石見佳子
- Journal Title
  
  食品と開発
  
  Volume: 49 Pages: 70-72
- NAID
  40020115270
- Data Source
  KAKENHI-PROJECT-25350178
[Journal Article] Distribution of 24-h urinary equol excretion as an indicator of the physiological range in healthy Japanese equol excreator.2014
- Author(s)
  Ueno T, Abiru Y, Uchiyama S, Ishimi Y.
- Journal Title
  
  J Funct Foods
  
  Volume: 7 Pages: 129-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350178
[Journal Article] Ｉｎｔｅｒａｃｔｉｏｎ　ｏｆ　human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-72014
- Author(s)
  Kusunoki, S. and Ishimi, Y.
- Journal Title
  
  FEBS J.
  
  Volume: 281 Issue: 4 Pages: 1057-1067
- DOI
  10.1111/febs.12668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570204, KAKENHI-PROJECT-26440002
[Journal Article] Translocation and stability of replicative DNA helicases upon encountering DNA-protein cross-links2013
- Author(s)
  Nakano, T., Miyamoto-Matsubara, M., Shoulkamy, M.I., Salem, A.M., Pack, S.P., Ishimi, Y. and Ide, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Pages: 4649-4658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570204
[Journal Article] Protein interaction and cellular localization of human CDC452013
- Author(s)
  Takaya, J., Kusunoki, S. and Ishimi, Y.
- Journal Title
  
  J. Biochem.
  
  Volume: 153 Pages: 381-388
- NAID
  40019622745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570204
[Journal Article] Possible role of <i>S</i>-equol on bone loss via amelioration of inflammatory indices in ovariectomized mice2013
- Author(s)
  Nishide Y, Tousen Y, Inada M, Miyaura C, Ishimi Y
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 53 Issue: 1 Pages: 41-48
- DOI
  10.3164/jcbn.12-123
- NAID
  130004879339
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350178
[Journal Article] Inhibition of DNA binding of MCM2-7 complex by phosphorylation with cyclin-dependent kinases2013
- Author(s)
  Moritani, M. and Ishimi, Y.
- Journal Title
  
  J. Biochem.
  
  Volume: 154 Pages: 363-372
- NAID
  40019817570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570204
[Journal Article] Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase2012
- Author(s)
  Sugiyama, T., Chino, M., Tsurimoto, T., Nozaki, N. and Ishimi, Y.
- Journal Title
  
  J. Biochem.
  
  Volume: 151 Pages: 129-137
- NAID
  10031166051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570204
[Journal Article] Effect of an MCM4 mutation that causes tumours in mouse on human MCM4/6/7 complex formation2012
- Author(s)
  Watanabe, E., Ohara, R. and Ishimi, Y.
- Journal Title
  
  J. Biochem.
  
  Volume: 152 Pages: 191-198
- NAID
  10031166128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570204
[Journal Article] Interaction of human MCM2-7 proteins with TIM, TIPIN and Rb.2010
- Author(s)
  Numata Y, Ishihara S, Hasegawa N, Nozaki N, Ishimi Y
- Journal Title
  
  J.Biochem. 147
  
  Pages: 917-927
- NAID
  10027876760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] DNA helicase activity in purified human RECQL4 protein.2009
- Author(s)
  Suzuki, T., Ishimi, Y., et.al.
- Journal Title
  
  J.Biochem.
  
  Volume: 146 Pages: 327-335
- NAID
  10026303147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] 複製開始と進行におけるMCM蛋白質複合体.質核酸酵素-増刊号2009
- Author(s)
  石見幸男
- Journal Title
  
  染色体サイクル(共立出版) 54巻4号
  
  Pages: 364-369
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] 複製開始と進行における酸CM蛋白質複合体2009
- Author(s)
  石見幸男
- Journal Title
  
  蛋白質核酸酵素 27(10)
  
  Pages: 364-369
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase.2009
- Author(s)
  Ishimi Y, Sugiyama T, Nakaya R, Kanamori M, Kohno T, Enomoto T, Chino M
- Journal Title
  
  FEBS J. 276
  
  Pages: 3382-3391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] DNA helicase activity in purified human RECQL4 protein2009
- Author(s)
  Suzuki, T., Kohno, T. & Ishimi, Y
- Journal Title
  
  J. Biochem in press
- NAID
  10026303147
- Data Source
  KAKENHI-PROJECT-17370059
[Journal Article] Effect of heliquinomycin on the activity of human MCM4/6/7 helicase2009
- Author(s)
  Ishimi, Y., Sugiyama, T., Nakaya, R., Kanamori, M., Kohno, T., Enomoto, T. & Chino, M
- Journal Title
  
  FEBS J in press
- Data Source
  KAKENHI-PROJECT-17370059
[Journal Article] Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase.2009
- Author(s)
  Ishimi, Y., et.al.
- Journal Title
  
  FEBS J.
  
  Volume: 276 Pages: 3382-3391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] 複製開始と進行におけるMCM蛋白質複合体2009
- Author(s)
  石見幸男
- Journal Title
  
  蛋白質核酸酵素
  
  Volume: 27(10) Pages: 364-369
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] DNA helicase activity in purified human RECQL4 protein.2009
- Author(s)
  Suzuki T, Kohno T, Ishimi Y
- Journal Title
  
  J.Biochem. 146
  
  Pages: 327-335
- NAID
  10026303147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] Proteosome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells2008
- Author(s)
  Takezawa, J., Ishimi, Y. and Yamada, K
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 863-871
- Data Source
  KAKENHI-PROJECT-17370059
[Journal Article] Biochemical characterization of fragmented human MCM22008
- Author(s)
  Komamura-Kohno, Y., Tanaka, R., Omori, A., Kohno, T. and Ishimi, Y
- Journal Title
  
  FEBS J. 275
  
  Pages: 727-738
- Data Source
  KAKENHI-PROJECT-17370059
[Journal Article] Biochemical characterization of fragmented human MCM2.2008
- Author(s)
  Komamura-Kohno Y, Tanaka R, Omori A, Kohno T, IshimiY
- Journal Title
  
  FEBS J. 275
  
  Pages: 727-738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells2006
- Author(s)
  Komamura-Kohno, Y., Karasawa-Shimizu, K., Saitoh, T., Sato, M., Hanaoka, F., Tanaka, S. and Ishimi, Y
- Journal Title
  
  FEBS J. 273
  
  Pages: 1224-1239
- Data Source
  KAKENHI-PROJECT-17370059
[Journal Article] Phosphorylation of MCM4 at sites inactivating DNA helicase activity of the MCM4-MCM6-MCM7 complex during Epstein-Barr virus productive replication.2006
- Author(s)
  Kudoh A, Daikoku T, Ishimi Y, Kawaguchi Y, Shirata N, Iwahori S, Isomura H, Tsurumi T
- Journal Title
  
  J.Virol 80
  
  Pages: 10064-10072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] Phosphorylation of MCM4 at sites inactivating DNA helicase activity of the MCM4-MCM6-MCM7 complex during Epstein-Barr virus productive replication2006
- Author(s)
  Kudoh, A., Daikoku, T., Ishimi, Y. Kawaguchi, Y., Shirata,N. Iwahori, S., Isomura H. & Tsurumi, T
- Journal Title
  
  J. Virol. 80
  
  Pages: 10064-10072
- Data Source
  KAKENHI-PROJECT-17370059
[Journal Article] Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells.2006
- Author(s)
  Komamura-Kohno Y, Karasawa-Shimizu K, Saitoh T, Sato M, Hanaoka F, Tanaka S, Ishimi Y
- Journal Title
  
  FEBS J. 273
  
  Pages: 1224-1239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] Human CDK2 inhibition modifies the dynamics of chromatin-bound minichromosome maintenance complex and replication protein A.2005
- Author(s)
  Zhu Y, Ishimi Y, Tanudji M, Lees E
- Journal Title
  
  Cell Cycle 4
  
  Pages: 1254-1263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17080003
[Journal Article] Human CDK2 inhibition modifies the dynamics of chromatin-bound minichromosome maintenance complex and replication protein A2005
- Author(s)
  Zhu, Y., Ishimi, Y., Tanudji, M. and Lees, E
- Journal Title
  
  Cell cycle 4
  
  Pages: 1254-1263
- Data Source
  KAKENHI-PROJECT-17370059
[Journal Article] Effect of heliquinomycin on the activity of human MCM4/6/7 helicase
- Author(s)
  Ishimi Y. et.al.
- Journal Title
  
  FEES J (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17370059
[Journal Article] Binding of human MCM-BP with MCM2-7 proteins
- Author(s)
  Kon, R., Kusunoki, S., Nozaki, N. and Ishimi, Y.
- Journal Title
  
  In DNA replication-Current advances
  
  Volume: (In Tech) Pages: 545-564
- Data Source
  KAKENHI-PROJECT-23570204
[Presentation] Assessment of safety and efficacy of phytoestrogen, isoflavone, on bone metabolism in animal models.2018
- Author(s)
  Ishimi Y、Tousen Y
- Organizer
  8th Annual World Congress of Molecular & Cell Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00902
[Presentation] 非荷重モデルマウスの骨密度低下に対するβ-カロテン摂取の影響2018
- Author(s)
  東泉裕子、松本雄宇、石見佳子
- Organizer
  第65回日本栄養改善学会学術総会
- Data Source
  KAKENHI-PROJECT-16K00902
[Presentation] HIF-1αとMCM2-7との相互作用－オートファジーとの関係2018
- Author(s)
  宮本優眞、山崎美穂、石見幸男
- Organizer
  2018年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-16K00902
[Presentation] カンゾウ由来健康食品の安全性・有効性評価2018
- Author(s)
  石見佳子、竹林純、東泉裕子、山内淳、渕野裕之、河野徳昭、乾貴幸、吉松嘉代、川原信夫
- Organizer
  第72回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-16K00902
[Presentation] 閉経後モデルマウスにおける葛の花由来イソフラボン抽出物の安全性・有効性評価－大豆イソフラボンとの比較－2018
- Author(s)
  東泉裕子、西出依子、竹林純、梅垣敬三、渕野裕之、河野徳昭、乾貴幸、吉松嘉代、川原信夫、石見佳子
- Organizer
  第72回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-16K00902
[Presentation] The effects of resistant starch on bone loss via intestinal microbiota and inflammation in ovariectomised mice.2017
- Author(s)
  Tousen Y、Matsumoto Y、Nagahata Y、Ishimi Y
- Organizer
  IUNS 21st International Congress of Nutrition 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00902
[Presentation] MCMヘリカーゼの保存性と多様性2016
- Author(s)
  石見幸男
- Organizer
  日本進化学会第１８回東京大会
- Place of Presentation
  東京
- Year and Date
  2016-08-25
- Invited
- Data Source
  KAKENHI-PROJECT-26440002
[Presentation] 大豆イソフラボン代謝産物が骨粗鬆症モデルラットの血流および骨密度に及ぼす影響2016
- Author(s)
  東泉裕子、松本雄宇、小池理絵、平田成美、上野友美、内山成人、石見佳子
- Organizer
  第70回日本栄養・食糧学会大会
- Place of Presentation
  武庫川女子大学（兵庫県西宮市）
- Year and Date
  2016-05-14
- Data Source
  KAKENHI-PROJECT-25350178
[Presentation] MCM相互作用因子はMCM6のATP結合部位に結合する2016
- Author(s)
  細井淳駿、酒入拓、石見幸男
- Organizer
  第３９回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26440002
[Presentation] 大豆イソフラボンによる乳がん由来MCF-7細胞DNA複製の促進2016
- Author(s)
  石見幸男、匂坂有花、田中智紀、石見佳子
- Organizer
  平成２８年度日本生化学会関東支部例会、
- Place of Presentation
  自治医科大学
- Data Source
  KAKENHI-PROJECT-16K00902
[Presentation] Soy isoflavones metabolite, S-equol, relieves endothelial dysfunction and bone loss in ovariectomised rats.2015
- Author(s)
  Yuko Tousen, Michiko Kato, Yoriko Nishide, Tomomi Ueno, Shigeto Uchiyama, Yoshiko Ishimi
- Organizer
  12th Asian Congress of Nutrition 2015
- Place of Presentation
  Pacfico Yokohama（神奈川県横浜市ｊ）
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350178
[Presentation] 大豆イソフラボンとレジスタントスターチの併用摂取が骨粗鬆症モデルマウスの骨密度低下に及ぼす影響2015
- Author(s)
  東泉裕子、松本雄宇、長畑雄也、小林功、石見佳子
- Organizer
  第62回日本栄養改善学会学術総会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-25350178
[Presentation] 健康食品素材の有効性評価及び健康影響評価に関する研究2015
- Author(s)
  石見佳子
- Organizer
  第62回日本栄養改善学会学術総会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-25350178
[Presentation] Isoflavones and green kiwifruit:A pilot study assessing the effects on equol production and bone turnover in healthy postmenopausal New Zealand women2015
- Author(s)
  Marlena C Kruger, Catherine Middlemiss, Shinichi Katsumata, Yuko Tousen, Yoshiko Ishimi
- Organizer
  ISNAO 2015 9th International Symposium on Nutritional Aspects of Osteoporosis
- Place of Presentation
  Montreal,Canada
- Year and Date
  2015-06-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350178
[Presentation] The effects of isoflavones and resistant starch on inhibition of bone loss and increase in fat mass in ovariectomised mice.2015
- Author(s)
  Matsumoto Y, Tousen Y, Ono R, Nagahata Y, Kobayashi I, Ishimi Y
- Organizer
  12th Asian Congress of Nutrition 2015
- Place of Presentation
  Pacfico Yokohama（神奈川県横浜市ｊ）
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350178
[Presentation] 大豆イソフラボン代謝産物エクオールのDNA複製への影響2015
- Author(s)
  田中智紀、永島崚甫、東泉裕子、石見佳子、石見幸男
- Organizer
  平成27年度日本生化学会関東支部例会
- Place of Presentation
  新潟グランドホテル（新潟県新潟市）
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-25350178
[Presentation] CDK2/サイクリンAによるMCM2-7複合体のDNA結合阻害2013
- Author(s)
  石見幸男, 守谷真梨子
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Year and Date
  2013-09-12
- Data Source
  KAKENHI-PROJECT-23570204
[Presentation] 大豆イソフラボン代謝産物エクオールが閉経後骨粗鬆症モデルマウスの骨髄細胞中の遺伝子発現に及ぼす影響2013
- Author(s)
  西出　依子、只石　幹、小堀　真珠子、東泉裕子、加藤美智子、稲田　全規、宮浦千里、石見佳子
- Organizer
  日本栄養・食糧学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25350178
[Presentation] CDK2/サイクリンAによるMCM2-7複合体のDNA結合阻害2013
- Author(s)
  石見幸男, 守谷真梨子
- Organizer
  日本生化学会関東支部例会
- Place of Presentation
  山梨
- Year and Date
  2013-06-15
- Data Source
  KAKENHI-PROJECT-23570204
[Presentation] MCM-BPとMCM2-7の相互作用2013
- Author(s)
  楠俊輔, 石見幸男
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-23570204
[Presentation] ヒトCDC45のタンパク質相互作用と細胞内局在2012
- Author(s)
  高屋潤一郎, 野崎直仁, 石見幸男
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-23570204
[Presentation] Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase2011
- Author(s)
  Sugiyama, T., Chino, M., Tsurimoto, T., Nozaki, N. and Ishimi, Y.
- Organizer
  第３４回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23570204
[Presentation] ヘリキノマイシンと一本鎖DNAとの相互作用によるMCM4/6/7ヘリカーゼの阻害2011
- Author(s)
  杉山隆史, 千野信, 釣本俊樹, 野崎直仁, 石見幸男
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23570204
[Presentation] Effect of heliquinomycin on human MCM4/6/7 helicase.2009
- Author(s)
  Y.Ishimi
- Organizer
  Eukaryotic DNA replication and genome maintenance
- Place of Presentation
  Cold Spring Harbor, NY, USA
- Data Source
  KAKENHI-PROJECT-17080003
[Presentation] 乳がんを引き起こすMCM4タンパク質変異の解析2009
- Author(s)
  渡辺瑛美、石見幸男
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜(パシフィコ横浜、神奈川県)
- Data Source
  KAKENHI-PROJECT-17080003
[Presentation] ヒトMCM-BPタンパク質の機能解析2009
- Author(s)
  昆良子、石見幸男
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜(パシフィコ横浜、神奈川県)
- Data Source
  KAKENHI-PROJECT-17080003
[Presentation] Effect of heliquinomycin on human MCM4/6/7 helicase.2009
- Author(s)
  Y.Ishimi
- Organizer
  Eukaryotic DNA replication and genome maintenance.
- Place of Presentation
  Cold Spring Harbor, NY,USA.
- Data Source
  KAKENHI-PROJECT-17080003
[Presentation] ヒトRPAに直接的に相互作用するタンパク質の同定2009
- Author(s)
  中谷亮、石見幸男
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜(パシフィコ横浜、神奈川県)
- Data Source
  KAKENHI-PROJECT-17080003
[Presentation] 抗生物質合リキノマイシンのMCM4/6/7ヘリカーゼに対する効果2008
- Author(s)
  石見幸男
- Organizer
  第31回日本分子生物学会年会/第81回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-17080003
[Presentation] MCM2-7とMCM相互作用因子との結合2008
- Author(s)
  沼田祐樹、石原将太、長谷川直子、石見幸男
- Organizer
  日本分子生物学会/日本生化学会合同大会
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] ヒトRECQL4のヘリカーゼ活性2008
- Author(s)
  鈴木雄大、石見幸男
- Organizer
  日本分子生物学会/日本生化学会合同大会
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] RPAとDNA複製関連タンパク質との結合2008
- Author(s)
  中谷亮、石見幸男
- Organizer
  日本分子生物学会/日本生化学会合同大会
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] 抗生物質ヘリキノマイシンのMCM4/6/7ヘリカーゼに対する効果2008
- Author(s)
  石見幸男、杉山隆史、鈴木雄大、河野俊之、千野信
- Organizer
  日本分子生物学会/日本生化学会合同大会
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] 抗生物質ヘリキノマイシンのMCM4/6/7ヘリカーゼに対する効果2008
- Author(s)
  石見幸男
- Organizer
  第31回日本分子生物学会/第81回日本生化学会年会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] DNA複製に機能するDNAヘリカーゼの活性, 文部科学省特定領域研究(染色体サイクルの制御ネットワーク)2008
- Author(s)
  石見幸男
- Organizer
  第一回公開領域会議
- Year and Date
  2008-01-07
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] MCM2タンパク質のヒストンシャペロン活性2007
- Author(s)
  石見幸男
- Organizer
  第30回日本分子生物学会年会/第80回日本生化学会年会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] MCM2タンパク質のヒストンシャペロン活性2007
- Author(s)
  石見幸男、河野有紀、田中利好、河野俊之
- Organizer
  日本分子生物学会年会/日本生化学会年会合同大会
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] ヒトRECQL4のヘリカーゼ活性の解析2007
- Author(s)
  鈴木雄大、石見幸男
- Organizer
  第30回日本分子生物学会年会/第80回日本生化学会年会合同大会
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] Molecular dissection of human MCM2 protein2007
- Author(s)
  Komamura-Kohno, Y., Tanaka, S., Omori, A. and Ishimi Y
- Organizer
  Cold Spring Harbor Meeting on Eukaryotic DNA replication
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] Site-specific phosphorylation of MCM4 in human cells2005
- Author(s)
  Ishimi, Y., Komamura-Kohno, Y., Tanaka, S. Saitoh, T., Sato, M., Kato, C., Song, S.-Y., Okayasu, I. and Yamada.K
- Organizer
  Cold Spring Harbor Meeting on Eukaryotic DNA replication
- Data Source
  KAKENHI-PROJECT-17370059
[Presentation] CDK2/サイクリンAによるMCM2-7複合体のDNA結合阻害
- Author(s)
  石見幸男、守谷真梨子
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23570204
[Presentation] 大豆イソフラボン代謝産物エクオールのDNA複製への影響
- Author(s)
  田中知紀、永島峻甫、東泉裕子、石見幸男、石見佳子
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25350178
[Presentation] MCM-BPとMCM2-7の相互作用
- Author(s)
  楠俊輔、石見幸男
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23570204
[Presentation] ヒトがん組織細胞由来MCM4点変異の性質
- Author(s)
  石見幸男、入江大輝
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26440002
[Presentation] Protein interaction and cellular localization of human CDC45
- Author(s)
  Takaya, J ., Nozaki, N. and Ishimi, Y.
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23570204

1. Ishimi Yoshiko (50154159)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
2. TOUSEN Yuko (20360092)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
3. MASUKATA Hisao (00199689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TAKIZAWA Haruhiko (60154944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ISHIMI Yukio 石見 幸男

Research Projects

Research Products

Co-Researchers

Role of autophagy on cell growth and differenciation by phytoestorogens

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Mechanisms of assembly and inhibition of DNA replication factors including MCM proteinsPrincipal Investigator

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Assessment of efficacy and safety of isoflavone metabolite

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Protein assembly at DNA replication fork and role of replication DNA helicasePrincipal Investigator

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Studies on molecular assembly of replication proteins and regulation of their functions in initiation of chromosome DNA replication

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Elucidation of mechanisms of MCM helicase functionPrincipal Investigator

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[Book] すべての診療科で役立つ栄養学と食事・栄養療法2019

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[Book] 食品機能性成分の吸収・代謝・作用機序2018

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[Book] 食と微生物の事典2017

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[Book] 大豆イソフラボンの有用性と安全性2015

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[Book] Association between exercise and diet on maintaining bone health in postmenopausal women and female athletes2015

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[Book] Binding of human MCM-BP with MCM2-7 proteins. in DNA replication-current advances2011

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[Book] 染色体サイクル(複製開始と進行におけるMCMタンパク質複合体)2009

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[Book] 複製開始と進行におけるMCMタンパク質複合体(染色体サイクル(正井、升方、釣本、仁木、篠原編)蛋白質核酸酵素2009

Author(s)

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ISHIMI Yukio 石見幸男