HIROI Takachika 廣井隆親

Researcher Number	80228824
External Links
Affiliation (based on the past Project Information) *help	2020 – 2021: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 室長 2018 – 2019: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, プロジェクトリーダー 2010: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 副参事研究員 2008 – 2010: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 副参事研究員 2004 – 2005: 東京大学, 医科学研究所, 助手 1995 – 2001: 大阪大学, 微生物病研究所, 助手
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49070:Immunology-related / Virology Except Principal Investigator Immunology
Keywords	Principal Investigator IgA / 粘膜免疫 / TGF-β / IL-15 / Th2 / アレルギー / スギ花粉症 / 舌下免疫療法 / 作用機序 / 苦味レセプター … More / 花粉症 / 苦味受容体 / Regulatory T cells / Dendritic cells / Eosinophil / Oral tolerance / Intestinal lamina propria / Mucosal immunology / TGF-b / MHC-class II / 抑制性T細胞 / 樹状細胞 / 好酸球 / 経口免疫寛容 / 粘膜固有層 / Th1 / NALT / Mucosal Immunity / Vaccine / B-1 cell / Nasal Immunization / CMIS / B-2細胞 / IL-5R / IL-5 / IL-15R / 鼻粘膜固有層 / 鼻粘膜関連リンパ組織 / ワクチン / B-1細胞 / 経鼻免疫 / OVA / IL-4 / 舌下減感作療法 / 脱顆粒 / 抗原提示細胞 / T細胞 / 免疫寛容 / IgE … More Except Principal Investigator IgA / 粘膜免疫 / 粘膜アジュバント / 粘膜免疫調節因子 / 粘膜ワクチン / Mucosal immune system / 経口ワクチン / IL-12 / 経口免疫 / Th2型細胞 / 粘膜免疫機構 / Mucosal cytokine / mutant CT / Mucosal adjuvant / Secretory IgA / Mucosal vaccine / 粘膜アジュバンド / 経鼻ワクチン / 無毒化変異型CT / 粘膜免疫システム / B-2 cells / B-1 / Peyer's patch / Mucosal T cells / Epithelial cell / Mucosal intranet / 上皮細胞 / γδT細胞 / IL-7R / IL-7 / コレラ毒素 / 上皮細胞間リンパ球 / IL-10 / TCRδ遺伝子欠損マウス / 粘膜系γδT細胞 / 経口免疫寛容 / 粘膜誘導型寛容 / 粘膜細胞間イントラネット / 粘膜細胞間インターネット / 粘膜細胞イントラネット / CMIS独立型 / IL-15 / IL-5 / B-1細胞 / CMIS / パイエル板 / Mucosal Th2 / Mucosal Th1 / Mucosal Adjuvant / Mucosal Modulator / Mucosal Intranet / Mucosal Vaccine / Mucosal Immune System / レベル2 Th2型 / Th2型応答 / Th1型 / IFN-γ遺伝子欠損マウス / 無毒化リコンビナントサルモネラ菌 / Th1型細胞 / AIDSと粘膜免疫 / Th2型 / 粘膜系Th1型 / LT / HIV / 分泌型IgA / 粘膜系Th1 Less

Effects of bitter taste receptors expressed in CD4+ T cells and regulatory T cells on sublingual immunotherapyPrincipal Investigator
- Principal Investigator
  
  HIROI Takachika
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Molecular mechanisms of sublingual immunotherapyPrincipal Investigator
- Principal Investigator
  
  HIROI Takachika
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Induction of oral tolerance by plasmacytoid dendritic cells in the intestinal lamina propriaPrincipal Investigator
- Principal Investigator
  
  HIROI Takachika
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Mucosal Vaccine in Next Generation: Mechanisms of Nasal VaccinePrincipal Investigator
- Principal Investigator
  
  HIROI Takachika
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Osaka Universrty
Characterization of Novel Mucosal Modulator for IgA
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Characterization of mucosal intranet formed by γδ/αβ T cells and epithelial cells
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Immunology
- Research Institution
  Osaka University
AIDS粘膜ワクチン:Th1/Th2型細胞によるHIV特異的粘膜免疫の誘導
- Principal Investigator
  
  清野宏
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Mucosal Vaccines : Vectors and Adjuvants for Novel Th1 and Th2 cells
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Immunology
- Research Institution
  Osaka University
AIDS粘膜ワクチン:Th1/Th2型細胞によるHIV特異的粘膜免疫の誘導
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University

All 2021 2020 2019 2018 2011 2010 2009 2008 2005 2004

All Journal Article Presentation Book Patent

[Book] 舌下免疫療法の治療効果を予測するシステムを構築2010
- Author(s)
  廣井隆親
- Publisher
  Medical Tribune special Issue
- Data Source
  KAKENHI-PROJECT-20590502
[Book] 免疫療法:スギ花粉症舌下免疫療法の治療効果に関わるバイオマーカーの検索2010
- Author(s)
  渡邊伸昌、神沼修、廣井隆親
- Publisher
  アレルギー免疫
- Data Source
  KAKENHI-PROJECT-20590502
[Book] Recent advances in Otitis media2005
- Author(s)
  Fukuyama, S., Hiroi, T., et al.
- Total Pages
  150
- Publisher
  BC Decker, Lewiston, NY
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Suppressive effect of dexamethasone on murine Th9 cell-mediated nasal eosinophilic inflammation.2021
- Author(s)
  Koyama T, Miura K, Yamasaki N, Ogata S, Ito D, Saeki M, Hiroi T, Mori A, Kaminuma O
- Journal Title
  
  Asia Pac Allergy.
  
  Volume: 11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07190
[Journal Article] L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation.2021
- Author(s)
  Ito D, Miura K, Saeki M, Yamasaki N, Ogata S, Koyama T, Hiroi T, Mori A, Endou H, Hayashi K, Kaminuma O
- Journal Title
  
  Asia Pac Allergy.
  
  Volume: 11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07190
[Journal Article] A new mechanism of bronchial hyperresponsiveness revealed by murine Th9 cell-transferred asthma model.2020
- Author(s)
  Saeki M, Kaminuma O, Hiroi T.
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 155 Pages: 375-380
- NAID
  130007933869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07190
[Journal Article] Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production.2020
- Author(s)
  Tachibana M, Watanabe N, Koda Y, Oya Y, Kaminuma O, Katayama K, Fan Z, Sakurai F, Kawabata K, Hiroi T and Mizuguchi H
- Journal Title
  
  Int Immunol.
  
  Volume: 32 Issue: 3 Pages: 187-201
- DOI
  10.1093/intimm/dxz076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07190
[Journal Article] T cell-mediated nasal hyperresponsiveness in allergic rhinitis.2020
- Author(s)
  Kaminuma O, Nishimura T, Saeki M, Mori A, Hiroi T.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 43 Pages: 36-40
- NAID
  130007779207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07190
[Journal Article] Epicutaneous allergen administration without antigen delivery device induces local T cell response and alleviates food allergic enteropathy.2020
- Author(s)
  Morinaga M, Nakajima-Adachi H, Hiraide E, Kitamura N, Kaminuma O, Hiroi T, Ohashi-Doi K, Hachimura S.
- Journal Title
  
  Allergology International
  
  Volume: 69 Pages: 622-625
- NAID
  130007926236
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07190
[Journal Article] Mechanisms of allergen immunotherapy elucidated through integrated comparative analysis2019
- Author(s)
  Kaminuma O, Gotoh M, Okubo K, Nakaya A, Hiroi T.
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 154 Issue: 1 Pages: 23-27
- DOI
  10.1254/fpj.154.23
- NAID
  130007678408
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07190
[Journal Article] Involvement of taste receptoer in the effectiveness of subligual immunotherapy2019
- Author(s)
  Gotoh Minoru、Kaminuma Osamu、Nakaya Akihiro、Katayama Kazufumi、Akihiroi Nakaya、Watanabe Nobumasa、Saeki Mayumi、Nishimura Tomoe、Kitamura Noriko、Okubo Kimihiro、Hiroi Takachika
- Journal Title
  
  Allegology international
  
  Volume: 67 Pages: 421-424
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07190
[Journal Article] Potential mechanisms of T cell-mediated and eosinophil-independent bronchial hyperresponsiveness.2019
- Author(s)
  Saeki M, Kaminuma O, Nishimura T, Kitamura N, Mori A, Hiroi T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 12 Pages: 2980-2981
- DOI
  10.3390/ijms20122980
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06713, KAKENHI-PROJECT-18K07190, KAKENHI-PROJECT-18K08422, KAKENHI-PROJECT-18K19561
[Journal Article] Development of Rice-Seed-Based Oral Allergy Vaccines Containing Hypoallergenic Japanese Cedar Pollen Allergen Derivatives for Immunotherapy.2019
- Author(s)
  Takaiwa F, Yang L, Takagi H, Maruyama N, Wakasa Y, Ozawa K, Hiroi T.
- Journal Title
  
  J Agric Food Chem.
  
  Volume: 67 Issue: 47 Pages: 13127-13138
- DOI
  10.1021/acs.jafc.9b05421
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07190
[Journal Article] Thrombospondin 1-mediated suppression of mast cell degranulation is involved in the efficacy of sublingual immunotherapy2019
- Author(s)
  Kaminuma O, Kitamura N, Gotoh M, Shindo M, Watanabe N, Saeki M, Nishimura T, Mori A, Nemoto S, Tatsumi H, Okubo K, Hiroi T.
- Journal Title
  
  Allergol. Int.
  
  Volume: 68 Issue: Supplement.1 Pages: S9-S10
- DOI
  10.1016/j.alit.2019.03.007
- NAID
  130007709743
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07190, KAKENHI-PROJECT-18K08422, KAKENHI-PROJECT-19K09901
[Journal Article] Serum interactions are implicated in the mechanism of action of sublingual immunotherapy for Japanese ceder pollinosis2018
- Author(s)
  Kenichi Shimada、Minoru Gotoh、Kimihiro Okubo、Takachika Hiroi、Osamu Kaminuma、Akihiroi Nakaya
- Journal Title
  
  J Nippon Med Sch
  
  Volume: 85 Pages: 250-258
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07190
[Journal Article] Prevention of allergic asthma by vaccination with transgenic rice-seed expressing mite allergen : induction of allergen-specific oral tolerance without bystander suppression.2011
- Author(s)
  Suzuki, K., Kaminuma, O., Yang, L., Takai, T., Mori, A., Umezu-Goto, M., Ohtomo, T., Ohmachi, Y., Noda, Y., Hirose, S., Okumura, K., Ogawa, H., Takada, K., Hirasawa, M., Hiroi, T., Takaiwa, F.
- Journal Title
  
  Plant Biothecnol J.
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] Selective down-regulation of Th2 cytokines by C-terminal binding protein 2 in human T cells.2010
- Author(s)
  Kitamura, F., Kitamura, N., Mori, A., Tatsumi, H., Nemoto, S., Miyoshi, H., Miyatake, S., Hiroi, T., Kaminuma, O.
- Journal Title
  
  Int Arch Allergy Imunol.
  
  Volume: 152 Pages: 18-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] Rice seed ER-derived protein body as an efficient delivery vehicle for oral tolerogenic peptides.2010
- Author(s)
  Takagi, H., Hiroi, T., Hirose, S., Yang, L., Takaiwa, F.
- Journal Title
  
  Peptides.
  
  Volume: 31 Pages: 1421-1425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] Antibody-mediated blockade of IL-15 signaling reverses autoimmune intestinal damage in a mouse model of celiac disease2009
- Author(s)
  Yokoyama S., Watanabe N., Sato N., Filkoski L., Tanaka T., Miyasaka M. , Waldmann T.A., Hiroi T., Perera, P.L.
- Journal Title
  
  Proc. Natl Acad Sci USA 106
  
  Pages: 15849-54
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] Suppressive role of C-terminal binding protein 1 in IL-4 synthesis in human T cells2009
- Author(s)
  Kitamura N., Motoi Y., Mori A., Tatsumi H., Nemoto S., Miyoshi H., Kitamura F., Miyatake S., Hiroi T., Kaminuma O.
- Journal Title
  
  Biochem Biophys Res Commun 382
  
  Pages: 326-330
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] T. T-box 21 transcription factor is responsible for distorted TH2 differentiation in human peripheral CD4+ T cells2009
- Author(s)
  Kaminuma O., Kitamura F., Miyatake S., Yamaoka K., Miyoshi H, Inokuma S, Tatsumi H, Nemoto S, Kitamura N, Mori A, Hiroi
- Journal Title
  
  J Allergy Clin Immunol 123
  
  Pages: 813-823
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] T-box 21 transcription factor is responsible for distorted TH2 differentiation in human peripheral CD4^+ T cells2009
- Author(s)
  Kaminuma, O., Kitamura, F., Miyatake, S., Yamaoka, K., Miyoshi H, Inokuma S, Tatsumi H, Nemoto S, Kitamura N, Mori A, Hiroi, T.
- Journal Title
  
  J Allergy Clin Immunol 123
  
  Pages: 813-823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] Antibody-mediated blockade of IL-15 signaling reverses autoimmune intestinal damage in transgenic mouse model of celiac disease2009
- Author(s)
  Yokoyama, S., Watanabe, N., Sato, N., Filkoski, L., Tanaka, T., Miyasaka, M., Waldmann, TA., Hiroi, T. (corresponding author), Perera, LP.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] T-bet is responsible for incomplete Th2 differentiation in human peripheral CD4+ T cells2009
- Author(s)
  Kaminuma, O., Kitamura, F., Miyatake, S., Miyoshi, H., Miyawaki, A., Inokuma, S., Tatsumi, H., Kitamura, N., Mori, A., Hiroi, T.
- Journal Title
  
  J Allergy Clin Immunol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] Antibody-mediated blockade of IL-15 signaling reverses autoimmune intestinal damage in a mouse model of celiac disease2009
- Author(s)
  Yokoyama, S., Watanabe, N., Sato, N., Filkoski, L., Tanaka, T., Miyasaka, M., Waldmann, T.A., Hiroi, T., Perera, P.L.
- Journal Title
  
  Proc.Natl Acad Sci USA 106
  
  Pages: 15849-15854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] Development of transgenic rice expressing mite antigen for a new concept of immunotherapy2009
- Author(s)
  Suzuki, K., Kaminuma, O., Yang, L., Motoi, Y., Takai, T., Ichikawa, S., Okumura, K., Ogawa, H., Mori, A., Takaiwa, F., Hiroi, T.
- Journal Title
  
  Int Arch Allergy Immunol 149
  
  Pages: 21-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] Efficient induction of oral tolerance by fusing cholera toxin B subunit with allergen-specific T-cell epitopes accumulated in rice seed2008
- Author(s)
  Takagi, H., Hiroi, H., Yang, L., Takamura, K., Ishimitsu, R., Kawauchi, H., Takaiwa, F.
- Journal Title
  
  Vaccine 26
  
  Pages: 6027-6030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590502
[Journal Article] 粘膜免疫におけるIgAクラススイッチ2005
- Author(s)
  廣井隆親他
- Journal Title
  
  免疫2006 42
  
  Pages: 342-351
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] CCR7 is critically important for migration of immunomodulatory dendritic cells in intestinal lamina propria to mesenteric lymph nodes.2005
- Author(s)
  Jang, M.H., Hiroi, T., et al.
- Journal Title
  
  Journal of immunology 印刷中
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] 経口免疫寛容における粘膜固有層樹状細胞の役割2005
- Author(s)
  廣井隆親, 他
- Journal Title
  
  臨床免疫 44
  
  Pages: 104-108
- NAID
  40006859397
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] 経口免疫寛容における粘膜固有層樹状細胞の役割2005
- Author(s)
  廣井隆親他
- Journal Title
  
  臨床免疫 44
  
  Pages: 104-108
- NAID
  40006859397
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Prenatal Blockage of Lymphotoxin {beta} Receptor and TNF Receptor p55 Signaling Cascade Resulted in the Acceleration of Tissue Genesis for Isolated Lymphoid Follicles in the Large Intestine.2005
- Author(s)
  Kweon, M.N., Hiroi, T., et al.
- Journal Title
  
  Journal of immunology 174
  
  Pages: 4365-4372
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Differences in integrin-dependent phagocytosis among three hemocyte subpopulation of the Pacific oyster Crassostrea gigas.2005
- Author(s)
  Terahara, K., Hiroi, T., et al.
- Journal Title
  
  Dev.Comp.Immunol. 印刷中
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Absence of common cytokine receptor γ chain results in the development of colitis by IL-6-producing pathogenic CD4^+ T cells crγ^<-/Y> mice.2005
- Author(s)
  Kai, Y., Takahashi, I., Ishikawa, H., Hiroi, T., Mizushima, T., Kishi, D., Hamada, H., Tamagawa, H., Ito, T., Yoshizaki, K., Kishimoto, T., Matsuda, H., Kiyono, H.
- Journal Title
  
  Gastroentelogy (印刷中)
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4^+ T cells.2005
- Author(s)
  Kai, Y., Hiroi, T., et al.
- Journal Title
  
  Gastroenterology 128
  
  Pages: 922-934
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] IgA class switch in mucosal immunology2005
- Author(s)
  Hiroi, T. et al.
- Journal Title
  
  Immunology 2006 (Japanese) 42
  
  Pages: 342-351
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Prenatal blockage of LTβR and TNFRp55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine.2005
- Author(s)
  Kweon, M.N., Yamamoto, M., Rennert, P.D., Park, E.J., Hiroi, T., Kiyono, H.
- Journal Title
  
  Journal of Immunology (印刷中)
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] 腸管系樹状細胞の特性とその生物学的機能2005
- Author(s)
  廣井隆親他
- Journal Title
  
  BIO Clinica 20
  
  Pages: 43-49
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses.2005
- Author(s)
  Takagi, H., Hiroi, T., et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 102
  
  Pages: 17525-17530
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] 腸管系樹状細胞の特性とその生物学的機能2005
- Author(s)
  廣井隆親, 他
- Journal Title
  
  BIO Clinica 20
  
  Pages: 43-49
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] 粘膜免疫におけるIgAクラススイッチ2005
- Author(s)
  廣井隆親, 他
- Journal Title
  
  免疫2006 42
  
  Pages: 342-351
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Induction of oral tolerance by antigen presenting cells in the intestinal lamina propria2005
- Author(s)
  Hiroi, T. et al.
- Journal Title
  
  Clinical Immunology (Japanese) 44
  
  Pages: 104-108
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] 口腔内疾患と粘膜ワクチン2004
- Author(s)
  廣井隆親他
- Journal Title
  
  アニテックス 16
  
  Pages: 102-116
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] IgA isotype class switching occurs in the organized mucosal lymphoid tissue, but not in the diffused lamina propria of nasal and intestinal tissues.2004
- Author(s)
  Shikina, T., Hiroi, T., Iwatani, K., Jang M-N., Fukuyama, S., Tamura, M., Kubo, T., Ishikawa, H., Kiyono, H.
- Journal Title
  
  Journal of Immunology 172
  
  Pages: 6259-6264
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Biological functions of intestinal dendritic cells2004
- Author(s)
  Hiroi, T. et al.
- Journal Title
  
  BIO Clinica. 20
  
  Pages: 43-49
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Role of Gut-Associated Lymphoreticular Tissues in Antigen-Specific Intestinal IgA Immunity.2004
- Author(s)
  Yamamoto, M., Kweon, M.N., Rennert, P.D., Hiroi, T., Fujihashi, K., McGhee, J.R., Kiyono, H.
- Journal Title
  
  Journal of Immunology 173
  
  Pages: 762-769
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Intestinal villous M cells : An antigen entry site in the mucosal epithelium.2004
- Author(s)
  Jang, M-N., Kweon, M-N., Iwatani, K., Yamamoto, M., Terahara, K., Sasakawa, C., Suzuki, T., Nochi, T., Yokota, Y., Rennert, P.D., Hiroi, T., Tamagawa, H., Iijima, H., Kunisawa, J., Yuki, Y., Kiyono, H.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 93
  
  Pages: 3613-3618
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Intracellularly Expressed TLR2s and TLR4s Contribution to an Immuno-Silent Environment at the Ocular Mucosal Epithelium.2004
- Author(s)
  Ueta, M., Nochi, T., Jang, M-H., Kawasaki, S., Park, E-J., Igarashi, O., Hino, A., Kawasaki, S., Shikina, T., Hiroi, T., Kinoshita, S., Kiyono, H.
- Journal Title
  
  Journal of Immunology 173
  
  Pages: 3337-3347
- Data Source
  KAKENHI-PROJECT-16590399
[Journal Article] Oral disease and mucosal vaccine2004
- Author(s)
  Hiroi, T. et al.
- Journal Title
  
  Anitex. (Japanese) 16
  
  Pages: 102-116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590399
[Patent] 減感作療法における治療効果を予測するバイオマーカー2010
- Inventor(s)
  廣井隆親
- Industrial Property Rights Holder
  財団法人東京都医学研究機構
- Filing Date
  2010-10-25
- Overseas
- Data Source
  KAKENHI-PROJECT-20590502
[Patent] 減感作療法における治療効果を予測するバイオマーカー2010
- Inventor(s)
  廣井隆親、大久保公裕
- Industrial Property Rights Holder
  東京都医学研究機構
- Filing Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-20590502
[Patent] 減感作療法における治療効果を予測するバイオマーカー2009
- Inventor(s)
  廣井隆親
- Industrial Property Rights Holder
  財団法人東京都医学研究機構
- Filing Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] Calcineurin / NFATシグナルのダイバーシティを生む分子メカニズム.2020
- Author(s)
  神沼修,北村紀子,宮武昌一郎,森晶夫,廣井隆親.
- Organizer
  第93回日本生化学会大会.
- Data Source
  KAKENHI-PROJECT-18K07190
[Presentation] 花粉症患者CD4陽性T細胞におけるカフェインの効果について.2020
- Author(s)
  北村紀子,佐伯真弓,神沼修,廣井隆親,後藤穣.
- Organizer
  第4回アレルギー学会関東地方会.
- Data Source
  KAKENHI-PROJECT-18K07190
[Presentation] 経口免疫療法用デバイスとしての米蛋白顆粒の有用性.2019
- Author(s)
  佐伯真弓、西村友枝、神沼修、高木英典、森晶夫、高岩文雄、廣井隆親.
- Organizer
  アレルギー・好酸球研究会2019.
- Data Source
  KAKENHI-PROJECT-18K07190
[Presentation] アレルゲン免疫療法の効果発現に関わる好塩基球およびマスト細胞関連メディエーター2019
- Author(s)
  神沼修、後藤穣、中谷明弘、北村紀子、西村友枝、佐伯真弓、廣井隆親、森晶夫、大久保公裕.
- Organizer
  アレルギー・好酸球研究会2019.
- Data Source
  KAKENHI-PROJECT-18K07190
[Presentation] Differential mechanisms of Th2- and Th9-mediated bronchial hyperresponsiveness in mice.2019
- Author(s)
  Kaminuma O, Saeki M, Nishimura T, Kitamura N, Mori A, Hiroi T.
- Organizer
  第68回日本アレルギー学会学術大会.
- Invited
- Data Source
  KAKENHI-PROJECT-18K07190
[Presentation] アレルゲン発現米による制御性T細胞の誘導を介さない免疫寛容誘導.2019
- Author(s)
  佐伯真弓、西村友枝、神沼修、高木英典、森晶夫、高岩文雄、廣井隆親.
- Organizer
  第68回日本アレルギー学会学術大会.
- Data Source
  KAKENHI-PROJECT-18K07190
[Presentation] 舌下免疫療法における味覚受容体を介した奏功メカニズム.2019
- Author(s)
  佐伯真弓、後藤穣、大久保公裕、中谷明弘、北村紀子、西村友枝、神沼修、廣井隆親.
- Organizer
  第1回日本アレルギー学会関東地方会.
- Data Source
  KAKENHI-PROJECT-18K07190
[Presentation] 花粉症舌下免疫療法の効果発現機序の探索.2019
- Author(s)
  北村紀子、後藤穣、湯田厚司、佐伯真弓、神沼修、廣井隆親.
- Organizer
  第1回日本アレルギー学会関東地方会.
- Data Source
  KAKENHI-PROJECT-18K07190
[Presentation] スギ花粉症舌下免疫療法の個別化医療を目指した基礎研究2018
- Author(s)
  廣井隆親
- Organizer
  東京都福祉保健医療学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07190
[Presentation] スギ花粉症舌下免疫療法における治療効果を予測するバイオマーカーの検索2011
- Author(s)
  廣井隆親
- Organizer
  日本耳鼻科学会免疫アレルギー
- Place of Presentation
  大分(招待講演)
- Year and Date
  2011-02-12
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] Differential contribution of CCR4 expressed on Th2 and Th17 cells to antigen-induced airway inflammation2010
- Author(s)
  Kaminuma O, Kitamura F, Motoi Y, Suzuki K, Katayama K, Hiroi T, Ohtomo T, Mori A, Nagakubo D, Hieshima K, Yoshie O.
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] ZFPM1/CtBP1コンプレックスはGATA-3によるTh2分化を抑制する2010
- Author(s)
  神沼修,北村紀子,森晶夫,巽英樹,根本荘一,廣井隆親
- Organizer
  第60回日本アレルギー学会総会
- Place of Presentation
  東京
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] ヒトT細胞のIL-4産生に対するC-terminal binding proteinの役割2009
- Author(s)
  神沼修、北村紀子、本井祐二、北村ふじ子、宮武昌一郎、三好浩之、巽英樹、根本荘一、森晶夫、廣井隆親
- Organizer
  アレルギー・好酸球研究会2009
- Place of Presentation
  東京
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] マウスを用いた舌下免疫療法モデル実験系の開発2009
- Author(s)
  鈴木一矢、神沼修、森晶夫、廣井隆親
- Organizer
  アレルギー・好酸球研究会2009
- Place of Presentation
  東京
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] Hyperexpression of T-bet is responsible for incomplete human Th2 differentiation2009
- Author(s)
  Kaminuma, O., Kitamura, N., Mori, A., Tatsumi, H., Nemoto, S., Inokuma, S., Miyoshi, H., Kitamura, F., Miyatake, S., Yamaoka, K., Hiroi, T
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪府・大阪国際会議場
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] Hyperexpression of T-bet is responsible for incomplete human Th2 differentiation2009
- Author(s)
  Kaminuma O., Kitamura N., Mori A., Tatsumi H., Nemoto S., Inokuma S., Miyoshi H., Kitamura F., Miyatake S., Yamaoka K., Hiroi T.
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] T細胞依存性の好酸球性気道炎症に対するCCR4拮抗薬の作用2009
- Author(s)
  神沼修、大友隆之、森晶夫、長久保大輔、稗島州雄、義江修、鈴木一矢、廣井隆親
- Organizer
  第59回日本アレルギー学会秋季学術大会
- Place of Presentation
  秋田
- Year and Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] Prevention of allergen-induced airway inflammation by Der p 1 expressed transgenic rice2008
- Author(s)
  Suzuki, K., Lijun, Y., Takai, T., Ichikawa, S., Hirose, S., Mori, A., Umezu-Goto, M., Ohmachi, Y., Noda, Y., Okumura, K., Ogawa, H., Takada, K., Hirasawa, M., Kaminuma, O., Takaiwa, F., Hiroi, T.
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] T細胞依存性のアレルギー性炎症発症におけるCD44の役割2008
- Author(s)
  神沼修, 加藤茂樹, 大友隆之, 森晶夫, 廣井隆親
- Organizer
  第58回日本アレルギー学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590502
[Presentation] C-terminal transactivation domain is required for NFAT-mediated TNF-alpha synthesis by T cells2008
- Author(s)
  Kaminuma, O., Kitamura, F., Kitamura, N., Miyatake, S., Hiroi T
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590502

1. KIYONO Hiroshi (10271032)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. TAKAHASHI Ichiro (20206791)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. YAMAMOTO Masafumi (80210558)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 島岡要 (40281133)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. FUJIHASHI Kuhtaro

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MCGHEE Jerry

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KWEON Mi-na (80324846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 奥田研爾 (40124862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. VANCOTT John

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 佐伯真弓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIROI Takachika 廣井 隆親

Research Projects

Research Products

Co-Researchers

Effects of bitter taste receptors expressed in CD4+ T cells and regulatory T cells on sublingual immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Molecular mechanisms of sublingual immunotherapyPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Induction of oral tolerance by plasmacytoid dendritic cells in the intestinal lamina propriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mucosal Vaccine in Next Generation: Mechanisms of Nasal VaccinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of Novel Mucosal Modulator for IgA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of mucosal intranet formed by γδ/αβ T cells and epithelial cells

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

AIDS粘膜ワクチン:Th1/Th2型細胞によるHIV特異的粘膜免疫の誘導

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Mucosal Vaccines : Vectors and Adjuvants for Novel Th1 and Th2 cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

AIDS粘膜ワクチン:Th1/Th2型細胞によるHIV特異的粘膜免疫の誘導

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] 舌下免疫療法の治療効果を予測するシステムを構築2010

Author(s)

Publisher

Data Source

[Book] 免疫療法:スギ花粉症舌下免疫療法の治療効果に関わるバイオマーカーの検索2010

Author(s)

Publisher

Data Source

[Book] Recent advances in Otitis media2005

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Suppressive effect of dexamethasone on murine Th9 cell-mediated nasal eosinophilic inflammation.2021

Author(s)

Journal Title

Data Source

[Journal Article] L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation.2021

Author(s)

Journal Title

Data Source

[Journal Article] A new mechanism of bronchial hyperresponsiveness revealed by murine Th9 cell-transferred asthma model.2020

Author(s)

Journal Title

HIROI Takachika 廣井隆親