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TAKAYANAGI Atsushi  高柳 淳

ORCIDConnect your ORCID iD *help
… Alternative Names

高柳 淳  タカヤナギ アツシ

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Researcher Number 80245464
Other IDs
Affiliation (based on the past Project Information) *help 2016: 慶應義塾大学, 医学部(信濃町), 共同研究員
2005 – 2016: 慶應義塾大学, 医学部, 講師
2010: 慶応義塾大学, 医学部, 講師
1996 – 2002: 慶應義塾大学, 医学部, 助手
1998: School of Medicine,KEIO University Instructor, 医学部, 助手 … More
1995: 慶応義塾大学, 医学部, 助手
1994: 慶應義塾大学, 医学部, 助手
1992: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Tumor diagnosis / General surgery / Biological Sciences
Except Principal Investigator
膠原病・アレルギー・感染症内科学 / Ophthalmology / General surgery / Digestive surgery / Obstetrics and gynecology / Functional biochemistry … More / Digestive surgery / Endocrinology / Dermatology / Laboratory animal science / General fisheries / Molecular biology Less
Keywords
Principal Investigator
抗体 / 遺伝子導入 / イムノジーン / 一本鎖抗体 / 遺伝子治療 / EGFレセプター / ヒト型化 / EGFR / 扁平上皮癌 / リン酸化 … More / アポトーシス / IGFレセプター / 抗体ライブラリー / ライブラリー / 酵母 / ポリエチレンイミン / ヒト型化抗体 / 自殺遺伝子 / 組換えイムノジーン / scFv / 人工抗体 / 細胞特異的 … More
Except Principal Investigator
遺伝子導入 / 遺伝子治療 / HMGB1 / ゼブラフィッシュ / 自己免疫疾患 / 急性肝不全 / RNA修飾 / 肝移植 / 劇症肝不全 / イムノジーン / downregulation / CBP / AIRE / APS-1 / APECED / Autoimmune disease / 肝細胞移植 / sRAGE / snoRNA / リボソームRNA / 抗RNA抗体 / リボソーム / 体外循環 / サイトカイン / ノンコーディングRNA / 人工抗体 / 肝臓外科学 / モノクローナル抗体 / エンドサイトーシス / EGFレセプター / マイクロRNA / パピローマウイルス / 子宮頸がん / ヒトパピローマウイルス / ワクチン / 子宮頸癌 / cervical cancer / vaccine / human papillomavirus / Anti-tumor erowth / cancer molecular thera / single chain antibody / Anti-IGF-I receptor / Phage display法 / ヒト単鎖抗体 / 抗IGF-I 受容体 / 抗がん効果 / ダウンレギュレーション / がん分子標的治療法 / 単鎖抗体 / 抗IGF-I受容体 / liver transplantation / ischemia-reperfusion injury / genetransfer / antisence / NFкB / IкB / 肝虚血再灌流傷害 / NFkB / IkB / 肝虚血再灌流障害 / アンチセンス / NFκB / IκB / human amine oxidase / idebenone / Leber's disease / mause amine oxidase / promotor / retinal ganglion cell / ベクター / ヒトアミンオキシダーゼ / イデベノン / レーベル病 / マウスアミンオキシダーゼ / プロモーター / 網膜神経節細胞 / Dendritic cells / Antigen presenting cells / Thymus / 転写調節因子 / RelB / 免疫応答 / トランスジェニックマウス / SV40T抗原 / 樹状細胞 / 抗原提示細胞 / 胸腺 / immunogene / artificial antibody / monoclonal antibody / gene therapy / intra ocular tumor / melanoma / 人工一本鎖抗体 / 眼内腫瘍 / 悪性黒色腫 / Cell adhesion / Desmoglein / Cadherin / Recombinant toxin / Disease-specific therapy / B cell / Pemphigus / 細胞接着 / デスモグレイン / カドヘリン / 組換え毒素 / 疾患特異的治療法 / B細胞 / 天疱瘡 / 自己免疫性疾患 / RAGE / 可溶性受容体 / ゼブラフィッシュモデル / ディスケリン / rRNA / scaRNA / snRNA / 自己免疫 / sTLR / ホメオボックス遺伝子 / Tursiops / iPS細胞 / 不死化 / ゲノム解析 / 後肢 / 形態 / イルカ / 遺伝・育種 / バイオリアクター / 遺伝子 / ウィルス / 移植・再生医療 / 肝虚血再灌流障害モデル / 肝虚血再灌流 / 人工抗体ライブラリー / RNA抗体 / 疾患モデル / リボソーム病 / p53 / 核小体 / 発がん / 造血異常 / 翻訳 / 吸着治療 / 治療 / 人工肝臓 / アデノウィルス / 人工杭体 / ファージディスプレイ / モルフォリノアンチセンスオリゴ / SLE / 生体肝移植 / 抗サイトカイン療法 / HMGB-1 / ターゲッティング / 一本鎖抗体 / ジフテリア毒素 / イムノポーター / 抗体 / 部位特異的変異導入法 / 遺伝子解析 / Bacurovirus / 改変型MTプロモーター / 80K蛋白質 / アンチセンス発現ベクター / 細胞増殖シグナル伝達 Less
  • Research Projects

    (25 results)
  • Research Products

    (57 results)
  • Co-Researchers

    (32 People)
  •  Treatment for fulminant hepatitis focusing on soluble receptor for HMGB1 (sRAGE)

    • Principal Investigator
      Shinoda Masahiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Keio University
  •  Elucidation of molecular mechanism of cervical cancer and its clinical application

    • Principal Investigator
      Fujii Takuma
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Fujita Health University
  •  Developments of A New Antibody Library and Antibody ChipsPrincipal Investigator

    • Principal Investigator
      TAKAYANAGI Atsushi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor diagnosis
    • Research Institution
      Keio University
  •  Development of a new effective therapy of fulminant hepatitis to focus on sTLR.

    • Principal Investigator
      TANABE Minoru
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Keio University
  •  Loss of RNA modification and autoimmune diseases: a novel mechanism of the SLE pathogenesis

    • Principal Investigator
      KENMOCHI Naoya
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      University of Miyazaki
  •  Development of a new effective therapy of ischemia reperfusion injury of liver and small intestine.

    • Principal Investigator
      SINODA Masahiro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Keio University
  •  Ribosomal abnormalities and human diseases: Molecular pathogenesis of ribosomopathies

    • Principal Investigator
      KENMOCHI Naoya
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Molecular biology
    • Research Institution
      University of Miyazaki
  •  RNA modification and self-discrimination : A possible link to the pathogenesis of autoimmune disease

    • Principal Investigator
      KENMOCHI Naoya
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      University of Miyazaki
  •  Molelucar Biological Analysis for the mechanism of the hind limb formation of the dolphin with fin-shaped hind limbs

    • Principal Investigator
      YOSHIOKA Motoi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General fisheries
    • Research Institution
      Mie University
  •  Investigation of the treatment of fulminant hepatitis by inhibition of HMGB1

    • Principal Investigator
      TANABE Minoru
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Keio University
  •  Autoimmune diseases and RNA modifications: Molecular mechanism of pathogenesis of systemic lupus erythematosus.

    • Principal Investigator
      UECHI Tamayo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      University of Miyazaki
  •  Establishment of an effective therapy for fulminant hepatic failure focusing on IL-18 inhibition

    • Principal Investigator
      TANABE Minoru
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Keio University
  •  Insulin-like growth factor-I receptor-targeted cancer therapy

    • Principal Investigator
      FUJITA Yoko
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokai University
  •  抗体を利用した遺伝子導入法「ヒト型イムノジーン法」の開発Principal Investigator

    • Principal Investigator
      高柳 淳
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General surgery
    • Research Institution
      Keio University
  •  Prevention of hepatic ischemia-reperfusion injury by gene transfer of IкB antisense and its application to liver transplantation

    • Principal Investigator
      SHIMAZU Motohide
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Keio University
  •  抗体を利用した遺伝子導入法「組換えイムノジーン法」の改良Principal Investigator

    • Principal Investigator
      高柳 淳
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
  •  Study of theretinal ganglion cell specific gene, optic atrophy, and gene threrapy

    • Principal Investigator
      MASHIMA Yukihiko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  Roles of the Autoimmune Regulator (AIRE) Gene in Immune Response

    • Principal Investigator
      SHIMIZU Nobuyoshi
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Endocrinology
    • Research Institution
      Keio University
  •  ヒト型人工抗体を用いた細胞特異的生体内遺伝子導入法の開発Principal Investigator

    • Principal Investigator
      高柳 淳
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Keio University
  •  Development of antigen-specific B cell elimination by recombinant toxins in autoimmune diseases

    • Principal Investigator
      AMAGAI Masayuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Gene Therapy for Melanoma Using Artificial Antibody/DNA Complex

    • Principal Investigator
      OHTAKE Yuichiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      KEIO University
  •  ヒトEGFレセプターを標的とする人工抗体を用いた生体内遺伝子導入法の開発Principal Investigator

    • Principal Investigator
      高柳 淳
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Keio University
  •  モノクローナル抗体や一本鎖人工抗体を用いた遺伝子導入法による癌の遺伝子治療

    • Principal Investigator
      清水 信義
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Keio University
  •  抗体を利用した生体内遺伝子ターゲッティング法の開発と癌遺伝子治療への応用

    • Principal Investigator
      清水 信義
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Keio University
  •  細胞増殖シグナル伝達に関わる80K蛋白遺伝子の構造解析と転写制御

    • Principal Investigator
      SHIMIZU Nobuyoshi
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Keio University

All 2016 2014 2013 2012 2011 2010 2008 2007 2006 2005

All Journal Article Presentation Patent

  • [Journal Article] Therapeutic Potential of Transgenic Mesenchymal Stem Cells Engineered to Mediate Anti-HMGB1 Activity: Targeting of Colon Cancer2014

    • Author(s)
      Kikuchi, H., Yagi, H., Hasegawa, H., Ishii, Y., Okabayashi, K., Tsuruta, M., Hoshino, G., Takayanagi, A., Kitagawa, Y.
    • Journal Title

      Journal of Surgical Research

      Volume: S0022-4804 Issue: 1 Pages: 00188-00197

    • DOI

      10.1016/j.jss.2014.02.047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501343
  • [Journal Article] Recombinant Human IgG Antibodies Recognizing Distinct Extracellular Domains of EGF Receptor Exhibit Different Degrees of Growth Inhibitory Effects On Human A431 Cancer Cells.2013

    • Author(s)
      Chang, C., Takayanagi, A., Yoshida, T., Shimizu, N.
    • Journal Title

      Experimental Cell Research

      Volume: 319 Issue: 8 Pages: 1146-1155

    • DOI

      10.1016/j.yexcr.2013.03.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501343
  • [Journal Article] Screening of scFv-displaying phages recognizing distinct extracellular domains of EGF receptor by target-guided proximity labeling method2011

    • Author(s)
      Chang, C., Takayanagi, A., Yoshida, T. and Shimizu, N.
    • Journal Title

      J. Immunol. Methods

      Volume: 372 Pages: 127-136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659186
  • [Journal Article] Screening of scFv-displaying phages recognizing distinct extracellular domains of EGF receptor by target-guided proximity labeling method.2011

    • Author(s)
      Chang C, Takayanagi A, Yoshida T, Shimizu N.
    • Journal Title

      J Immunol Methods

      Volume: 372 Pages: 127-136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200070
  • [Journal Article] Construction and characterization of single-chain antibodies against human insulin-like growth factor-I receptor from hybridomas producing 1H7 or 3B7 monoclonal antibody2008

    • Author(s)
      Kusada Y, Morizono T, Matsumoto-Takasaki A, Sakai K, Sato S, Asanuma H, Takayanagi A, Fujita-Yamaguchi Y.
    • Journal Title

      J Biochem

      Volume: 143 Pages: 9-19

    • NAID

      10024907273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200070
  • [Journal Article] Construction and characterization of single-chain antibodies against human insulin-like growth factor-1 Receptor from hybridomas producing 1H7 and 3B7 monoclonal antibody2008

    • Author(s)
      Kusada, Y, Morizono, T., Matsumoto-Takasaki, A., Sakai, K., Sato, S., Asanuma, H., Takayanagi, A., and Fujita-Yamaguchi, Y.
    • Journal Title

      J.Biochem. 143

      Pages: 9-19

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17570120
  • [Journal Article] Construction and characterization of single-chain antibodies against human insulin-like growth factor-1 Receptor from hybridomas producing 1H7 and 3B7 monoclonal antibody2008

    • Author(s)
      Kusada, Y, Morizono, T., Matsumoto-Takasaki, A., Sakai, K., Sato, S., Asanuma, H., Takayanagi, A., Fujita-Yamaguchi, Y
    • Journal Title

      J. Biochem 143

      Pages: 9-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17570120
  • [Patent] Antibody and Use Thereof2012

    • Inventor(s)
      清水信義、高柳淳、吉田徹彦
    • Industrial Property Rights Holder
      慶應義塾大学、東亞合成株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-12-04
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24501343
  • [Patent] 抗RNA抗体のスクリーニング方法及びRNA抗体の製造方法2011

    • Inventor(s)
      剣持直哉、吉浜麻生、高柳淳、清水信義
    • Industrial Property Rights Holder
      剣持直哉、吉浜麻生、高柳淳、清水信義
    • Industrial Property Number
      2011-098698
    • Filing Date
      2011-04-26
    • Data Source
      KAKENHI-PROJECT-22370065
  • [Patent] 抗RNA抗体のスクリーニング方法及びRNA抗体の製造方法2011

    • Inventor(s)
      剣持直哉、吉浜麻生、高柳淳、清水信義
    • Industrial Property Rights Holder
      宮崎大学、慶應義塾
    • Filing Date
      2011-04-26
    • Data Source
      KAKENHI-PROJECT-22659186
  • [Patent] 抗RNA抗体のスクリーニング方法及びRNA抗体の製造方法2011

    • Inventor(s)
      剣持直哉,吉浜麻生,高柳淳,清水信義
    • Industrial Property Rights Holder
      宮崎大学,慶慮義塾大学
    • Industrial Property Number
      2011-098698
    • Filing Date
      2011-04-26
    • Data Source
      KAKENHI-PROJECT-22370065
  • [Patent] 抗RNA抗体のスクリーニング方法2011

    • Inventor(s)
      剣持直哉, 吉浜麻生, 高柳淳, 清水信義.
    • Industrial Property Rights Holder
      宮崎大学, 慶應義塾
    • Filing Date
      2011-04-26
    • Data Source
      KAKENHI-PROJECT-20200070
  • [Patent] 抗RNA抗体のスクリーニング方法2011

    • Inventor(s)
      剣持直哉、吉浜麻生、高柳淳、清水信義
    • Industrial Property Rights Holder
      宮崎大学、慶應義塾
    • Industrial Property Number
      2011-098698
    • Filing Date
      2011-04-26
    • Data Source
      KAKENHI-PROJECT-20200070
  • [Patent] 抗RNA抗体のスクリーニング方法及びRNA抗体の製造方法2011

    • Inventor(s)
      剣持直哉、吉浜麻生、高柳淳、清水信義
    • Industrial Property Rights Holder
      剣持直哉、吉浜麻生、高柳淳、清水信義
    • Industrial Property Number
      2011-098698
    • Filing Date
      2011-04-26
    • Data Source
      KAKENHI-PROJECT-22659186
  • [Presentation] HMGB1 targeting therapy for acute liver failure.2016

    • Author(s)
      篠田昌宏、溝田高聖, 雨宮隆介, 西山亮, 高柳淳, 島田薫, 海老沼浩利, 尾原秀明, 板野理, 北川雄光
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      アスティ徳島(徳島県徳島市)
    • Year and Date
      2016-07-14
    • Data Source
      KAKENHI-PROJECT-26430093
  • [Presentation] HMGB1に着目した急性肝不全の病態理解と治療法の開発2013

    • Author(s)
      篠田昌宏, 田中真之, 西山亮, 大島剛, 高野公徳, 海老沼浩利, 高柳淳, 山田晋吾, 宮庄拓, 須田康一, 林田哲, 八木洋, 阿部雄太, 日比泰造, 北郷実, 尾原秀明, 竹内裕也, 板野理, 丸山征郎, 田邉稔, 北川雄光
    • Organizer
      第39回日本急性肝不全研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591888
  • [Presentation] HMGB1に着目した急性肝不全の病態理解と体外循環吸着療法の可能性2013

    • Author(s)
      田中真之, 篠田昌宏, 西山亮, 高野公徳, 高柳淳, 丸山征郎, 田邉稔, 北川雄光
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24591888
  • [Presentation] ラット急性肝不全モデルにおけるHMGB1 A box遺伝子導入の効果2013

    • Author(s)
      雨宮隆介, 篠田昌宏, 田中真之, 高柳淳, 西山亮, 大島剛, 山田晋吾, 宮庄拓, 須田康一, 八木洋, 林田哲, 阿部雄太, 日比泰造, 北郷実, 尾原秀明, 竹内裕也, 板野理, 丸山征郎, 田邉稔, 北川雄光
    • Organizer
      第20回外科侵襲とサイトカイン研究会
    • Place of Presentation
      渋川
    • Data Source
      KAKENHI-PROJECT-24591888
  • [Presentation] HMGB1制御による急性肝不全に対する新治療の開発2013

    • Author(s)
      篠田昌宏,田邉稔,田中真之,西山亮,大島剛,高野公徳,海老沼浩利,高柳淳,山田晋吾,宮庄拓,須田康一,林田哲,八木洋,阿部雄太,日比泰造,北郷実,田中克典,尾原秀明,竹内裕也,板野理,丸山征郎,北川雄光
    • Organizer
      第40回日本集中治療医学会学術集会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-23591875
  • [Presentation] HMGB1に着目した急性肝不全の病態理解と治療法の開発2013

    • Author(s)
      篠田昌宏,田中真之,西山亮,大島剛,高野公徳,海老沼浩利,高柳淳,山田晋吾,宮庄拓,須田康一,林田哲,八木洋,阿部雄太,日比泰造,北郷実,尾原秀明,竹内裕也,板野理,丸山征郎,田邉稔,北川雄光
    • Organizer
      第39回日本急性肝不全研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591875
  • [Presentation] HMGB1 A box domainの遺伝子導入方法の確立2013

    • Author(s)
      田中真之, 篠田昌宏, 高柳淳, 西山亮, 大島剛, 高野公徳, 山田晋吾, 宮庄拓, 須田康一, 林田哲, 八木洋, 阿部雄太, 日比泰造, 北郷実, 尾原秀明, 竹内裕也, 板野理, 丸山征郎, 田邉稔, 北川雄光
    • Organizer
      第40回日本臓器保存生物医学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591875
  • [Presentation] HMGB1 A box domainの遺伝子導入方法の確立2013

    • Author(s)
      田中真之, 篠田昌宏, 高柳淳, 西山亮, 大島剛, 高野公徳, 山田晋吾, 宮庄拓, 須田康一, 林田哲, 八木洋, 阿部雄太, 日比泰造, 北郷実, 尾原秀明, 竹内裕也, 板野理, 丸山征郎, 田邉稔, 北川雄光
    • Organizer
      第40回日本臓器保存生物医学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591888
  • [Presentation] ラット急性肝不全モデルにおけるHMGB1 A box遺伝子導入の効果2013

    • Author(s)
      雨宮隆介, 篠田昌宏, 田中真之, 高柳淳, 西山亮, 大島剛, 山田晋吾, 宮庄拓, 須田康一, 八木洋, 林田哲, 阿部雄太, 日比泰造, 北郷実, 尾原秀明, 竹内裕也, 板野理, 丸山征郎, 田邉稔, 北川雄光
    • Organizer
      第20回外科侵襲とサイトカイン研究会
    • Place of Presentation
      渋川
    • Data Source
      KAKENHI-PROJECT-23591875
  • [Presentation] HMGB1に着目した急性肝不全の病態理解と体外循環吸着療法の可能性2013

    • Author(s)
      田中真之, 篠田昌宏, 西山亮, 高野公徳, 高柳淳, 丸山征郎, 田邉稔, 北川雄光
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23591875
  • [Presentation] 急性肝不全患者におけるHMGB1動態と動物モデルにおけるHMGB1制御の効果2012

    • Author(s)
      篠田昌宏,田邉稔,高野公徳,大島剛,西山亮,海老沼浩利,高柳淳,山田晋吾,宮庄拓,松原健太郎,須田康一,林田哲,八木洋,尾原秀明,竹内裕也,板野理,河地茂行,斉藤英胤,日比紀文,丸山征郎,北川雄光
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張
    • Data Source
      KAKENHI-PROJECT-23591875
  • [Presentation] A New Periplasmic Chaperon Vector for Improvement of Phage-Displayed Antibody Library2012

    • Author(s)
      Atsushi Takayanagi, Tetsuhiko Yoshida, Nobuyoshi Shimizu
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Data Source
      KAKENHI-PROJECT-24501343
  • [Presentation] HMGB1阻害タンパクA boxの遺伝子導入ベクタ-の確立とラット急性肝不全モデルにおける予後改善効果2012

    • Author(s)
      篠田昌宏,田邉稔,西山亮,高柳淳,大島剛,田中真之,山田晋吾,宮庄拓,須田康一,福永興壱,八木洋,林田哲,松原健太郎,北郷実,尾原秀明,竹内裕也,板野理,河地茂行,丸山征朗,北川雄光
    • Organizer
      第48回日本腹部救急医学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23591875
  • [Presentation] HMGB1 A box遺伝子導入ベクタ-の樹立とラット急性肝不全モデルにおける予後改善効果2012

    • Author(s)
      篠田昌宏,田邉稔,西山亮,高柳淳,大島剛,田中真之,山田晋吾,宮庄拓,須田康一,松原健太郎,八木洋,林田哲,北郷実,尾原秀明,竹内裕也,板野理,福永興壱,河地茂行,丸山征朗,北川雄光
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591875
  • [Presentation] HMGB1阻害タンパクA boxの遺伝子導入ベクターの確立とラット急性肝不全モデルにおける予後改善効果2012

    • Author(s)
      篠田昌宏, 田邉稔, 西山亮, 高柳淳, 大島剛, 田中真之, 山田晋吾, 宮庄拓, 須田康一, 福永興壱, 八木洋, 林田哲, 松原健太郎, 北郷実, 尾原秀明, 竹内裕也, 板野理, 河地茂行, 丸山征朗, 北川雄光
    • Organizer
      第48回日本腹部救急医学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Gene transfer of a box domain from high mobility group box 1 in rat acute liver failure model2011

    • Author(s)
      Shinoda M, Tanabe M, Takayanagi A, Nishiyama R, Oshima G, Yagi H, Maruyama I, Kitagawa Y
    • Organizer
      International Surgical Week ISW 2011
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] HMGB1制御による急性肝不全に対する新治療の開発.2011

    • Author(s)
      篠田昌宏, 田邉稔, 高野公徳, 大島剛, 西山亮, 海老沼浩利, 高柳淳, 山田晋吾, 宮庄拓, 福永興壱, 松原健太郎, 須田康一, 林田哲, 八木洋, 尾原秀明, 竹内裕也, 板野理, 河地茂行, 斎藤英胤, 日比紀文, 丸山征郎, 北川雄光
    • Organizer
      第1回HMGB1シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2011-02-26
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Gene Transfer of the A box domain of HMGB1 into the Liver in rat acute liver failure model2011

    • Author(s)
      Shinoda M, Tanabe M, Nishiyama R, Takayanagi A, Oshima G, Takano K, Yagi H, Kawachi S, Maruyama I, Kitagawa Y
    • Organizer
      97th American College of Surgeons Clinical Congre
    • Place of Presentation
      San Francisco
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Establishment of rat hepatocyte producing high mobility group box 1 inhibitor2011

    • Author(s)
      Shinoda M, Nishiyama R, Tanabe M, Takayanagi A, Oshima G, Takano K, Sanuki N, Nagarekawa T, Miyasho T, Yamada S, Fukunaga K, Suda K, Matsubara K, Obara H, Takeuchi H, Itano O, Kawachi S, Maruyama I, Kitagawa Y
    • Organizer
      XXXVIII Congress of the European Society for Artificial Organs(ESAO 2011) and IV Biennial Congress of the International Federation on Artificial Organs(IFAO 2011)
    • Place of Presentation
      Portugal
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Gene Transfer of the High Mobility Group Box 1 Inhibitor in Rat Acute Liver Failure Model.2011

    • Author(s)
      Shinoda M, Tanabe M, Takayanagi A, et al.
    • Organizer
      The 2011 Joint International Congress of ILTS, ELITA, & LICAGE
    • Place of Presentation
      Valencia
    • Data Source
      KAKENHI-PROJECT-23591875
  • [Presentation] Efficient Production of Recombinant Antibodies in Mammalian Cells by Transient Transfection of Expression Vectors with 2.5K "PEI-MAX"2011

    • Author(s)
      高柳淳, 吉田徹彦, 清水信義
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22659186
  • [Presentation] Gene Transfer of the High Mobility Group Box 1 Inhibitor in Rat Acute Liver Failure Model2011

    • Author(s)
      Shinoda M, Tanabe M, Takayanagi A, Nishiyama R, Oshima G, Takano K, Yagi H, Suda K, Takeuchi H, Hayashida T, Yamada S, Miyasho T, Fukunaga K, Obara H, Itano O, Kawachi S, Maruyama I, Kitagawa Y
    • Organizer
      The 2011 Joint International Congress of ILTS
    • Place of Presentation
      ELITA, & LICAGE, Valencia
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Gene Transfer of the A box domain of HMGB1 into the Liver in rat acute liver failure model2011

    • Author(s)
      Shinoda M, Tanabe M, Nishiyama R, Takayanagi A, Oshima G, Takano K, Yagi H, Kawachi S, Maruyama I, Kitagawa Y
    • Organizer
      97th American College of Surgeons Clinical Congress
    • Place of Presentation
      San Francisco
    • Data Source
      KAKENHI-PROJECT-23591875
  • [Presentation] Gene Transfer of the High Mobility Group Box 1 Inhibitor in Rat Acute Liver Failure Model2011

    • Author(s)
      Shinoda M, Tanabe M, Takayanagi A, et al
    • Organizer
      The 2011 Joint International Congress of ILTS, ELITA, & LICAGE
    • Place of Presentation
      Valencia, Spain
    • Year and Date
      2011-06-22
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] ラット急性肝不全モデルにおけるHMGB1阻害タンパク遺伝子導入による治療効果の検討2011

    • Author(s)
      西山亮, 篠田昌宏, 田邉稔, 高柳淳, 大島剛, 八木洋, 竹内裕也, 河地茂行, 丸山征郎, 北川雄光
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] HMGB1阻害タンパクA boxの遺伝子導入ベクターの確立とラット急性肝不全モデルにおける予後改善効果2011

    • Author(s)
      田中真之, 篠田昌宏, 田邉稔, 西山亮, 高柳淳, 大島剛, 山田晋吾, 宮庄拓, 須田康一, 松原健太郎, 八木洋, 林田哲, 北郷実, 尾原秀明, 竹内裕也, 板野理, 河地茂行, 丸山征郎, 北川雄光
    • Organizer
      第18回外科侵襲とサイトカイン研究会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Gene transfer of a box domain from high mobility group box 1 in rat acute liver failure model2011

    • Author(s)
      Shinoda M, Tanabe M, Takayanagi A, et al
    • Organizer
      International Surgical Week ISW 2011
    • Place of Presentation
      Pacifico Yokohama, Japan
    • Year and Date
      2011-08-31
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Serum level of high mobility group box 1 in patients with fulminant hepatic failure and its blockade in rat model.2010

    • Author(s)
      Oshima G, Shinoda M, Tanabe M, Takayanagi A, Miyasho T, Yamada S, Ebinuma H, Takano K, Hibi T, Suda K, Obara H, Takeuchi H, Kawachi S, Fukunaga K, Hibi T, Maruyama I, Kitagawa Y.
    • Organizer
      ILTS 16th Annual International Congress
    • Place of Presentation
      Hong Kong
    • Year and Date
      2010-06-18
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Serum high-mobility group box 1 level in the patients with fulminant hepatic failure and its blockade effect in rat model2010

    • Author(s)
      Oshima G, Shinoda M, Tanabe M, Takayanagi A, Miyasho T, Yamada S, Ebinuma H, Takano K, Hibi T, Suda K, Obara H, Takeuchi H, Kawachi S, Fukunaga K, Hibi T, Maruyama I, Kitagawa Y
    • Organizer
      45th Annual Meeting of the European Association for the Study of the Liver(EASL)-The International Liver Congress 2010-
    • Place of Presentation
      Vienna
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Serum level of high mobility group box 1 in patients with fulminant hepatic failure and its blockade in rat model2010

    • Author(s)
      Oshima G, Shinoda M, Tanabe M, Takayanagi A, Miyasho T, Yamada S, Ebinuma H, Takano K, Hibi T, Suda K, Obara H, Takeuchi H, Kawachi S, Fukunaga K, Hibi T, Maruyama I, Kitagawa Y
    • Organizer
      ILTS 16th Annual International Congress
    • Place of Presentation
      Hong Kong
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Serum high-mobility group box 1 level in the patients with fulminant hepatic failure and its blockade effect in rat model.2010

    • Author(s)
      Oshima G, Shinoda M, Tanabe M, Takayanagi A, Miyasho T, Yamada S, Ebinuma H, Takano K, Hibi T, Suda K, Obara H, Takeuchi H, Kawachi S, Fukunaga K, Hibi T, Maruyama I, Kitagawa Y.
    • Organizer
      45th Annual Meeting of the European Association for the Study of the Liver (EASL) -The International Liver Congress 2010-
    • Place of Presentation
      Vienna
    • Year and Date
      2010-04-17
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Serum high mobility group box 1 level in the patients with fulminant hepatic failure and its blockade in rat model2010

    • Author(s)
      Shinoda M, Tanabe M, Oshima G, Takayanagi A, Miyasho T, Yamada S, Ebinuma H, Takano K, Hibi T, Suda K, Obara H, Takeuchi H, Kawachi S, Fukunaga K, Saito H, Hibi T, Maruyama I, Kitagawa Y
    • Organizer
      The 4th International HMGB1 Symposium
    • Place of Presentation
      Helsinki
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] ヒトゲノム情報と人工抗体ライブラリーを活用したプロテオーム解析の新戦略2010

    • Author(s)
      高柳淳
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22659186
  • [Presentation] Serum high mobility group box 1 level in the patients with fulminant hepatic failure and its blockade in rat model.2010

    • Author(s)
      Shinoda M, Tanabe M, Oshima G, Takayanagi A, Miyasho T, Yamada S, Ebinuma H, Takano K, Hibi T, Suda K, Obara H, Takeuchi H, Kawachi S, Fukunaga K, Saito H, Hibi T, Maruyama I, Kitagawa Y.
    • Organizer
      The 4th International HMGB1 Symposium
    • Place of Presentation
      Helsinki
    • Year and Date
      2010-06-22
    • Data Source
      KAKENHI-PROJECT-21591762
  • [Presentation] Comparison of monoclonal antibodies against human IGF-I receptor prepared from mice to those prepared by phage-display technology in votro2007

    • Author(s)
      Kusada, Y., Sekine, K., Sato, S., Asanuma, H., Takayanagi, A., Shimizu, N., and Fujita-Yamaguchi, Y.
    • Organizer
      WIRC
    • Place of Presentation
      Davos,Switzerland
    • Data Source
      KAKENHI-PROJECT-17570120
  • [Presentation] Comparison of monoclonal antibodies against human IGF-I receptor prepared from mice to those prepared by phage-display technology in vitro2007

    • Author(s)
      Kusada, Y., Sekine, K., Sato, S., Asanuma, H., Takayanagi, A., Shimizu, N., Fujita-Yamaguchi, Y
    • Place of Presentation
      WIRC, Davos, Switzerland
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17570120
  • [Presentation] Isolation and characterization of human single-chain antibodies against insulin receptor isoform A by phage-display techniques2007

    • Author(s)
      Kusada, Y., Sekine, K., Takayanagi, A., Shimizu, N., and Fujita-Yamaguchi, Y.
    • Organizer
      11th Annual Meeting of Japanese Society for Molecular Targeted Therapy for Cancer
    • Place of Presentation
      Osaka,Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17570120
  • [Presentation] Isolation and characterization of human single-chain antibodies against insulin receptor isoform A by phage-display techniques2007

    • Author(s)
      Kusada, Y, Sekine, K, Takayanagi, A., Shimizu, N., Fujita-Yamaguchi, Y
    • Organizer
      11th Annual Meeting of Japanese Society for Molecular Targeted Therapy for Cancer
    • Place of Presentation
      Osaka, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17570120
  • [Presentation] Comparison of monoclonal antibodies against human IGF-I receptor prepared from mice to those prepared by phage-display technology in vitro2007

    • Author(s)
      Kusada, Y., Sekine, K., Sato, S., Asanuma, H., Takayanagi, A., Shimizu, N., and Fujita-Yamaguchi, Y.
    • Organizer
      WIRC
    • Place of Presentation
      Davos,Switzerland
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17570120
  • [Presentation] Isolation and characterization of single-chain antibodies(scFvs)against insulin-like growth factor-I receptor(IGF-IR)and/or insulin receptor isoform A(IR-A)2006

    • Author(s)
      Kusada, Y., Sekine, H., Ohtani, M., Sakai, K., Yajima, Y., Takayanagi, A., Shimizu, N., and Fujita-Yamaguchi, Y.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto,Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17570120
  • [Presentation] Isolation and characterization of single-chain antibodies(scFvs) against insulin-like growth factor-I receptor(IGF-IR) and/or insulin receptor isoform A(IR-A)2006

    • Author(s)
      Kusada, Y., Sekine, H., Ohtani, M., Sakai, K., Yajima, Y., Takayanagi, A., Shimizu, N., Fujita-Yamaguchi, Y
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17570120
  • [Presentation] Isolation and characterization of human single-chain antibodies(scFv)against insulin-like growth factor I receptor(IGF-IR)2005

    • Author(s)
      Kusada, Y., Morizono, T., Sakai, K., Takayanagi, A., Shimizu, N., and Fujita-Yamaguchi, Y.
    • Organizer
      78th Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Kobe,Japan.
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17570120
  • [Presentation] Isolation and characterization of human single-chain antibodies(scFv) against insulin-like growth factor I receptor(IGF-IR)2005

    • Author(s)
      Kusada, Y., Morizono, T., Sakai, K., Takayanagi, A., Shimizu, N., Fujita-Yamaguchi, Y
    • Organizer
      78th Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Kobe, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17570120
  • 1.  SHINODA Masahiro (50286499)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 31 results
  • 2.  SHIMIZU Nobuyoshi (50162706)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  TANABE Minoru (50197513)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 30 results
  • 4.  KENMOCHI Naoya (00133124)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  蒲生 忍 (90122308)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  OHTAKE Yuichiro (30233159)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  MASHIMA Yukihiro (40157186)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  NISHIYAMA Ryo (70528322)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 22 results
  • 9.  ASAKAWA Shuichi (30231872)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  KUDOH Jun (80178003)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  陳 嘉竝 (10296725)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  UECHI Tamayo (10381104)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TAKAMI Yasunari (80236356)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  HIGA Sayomi (20381105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SUZUKI Tsutomu (20292782)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YOSHIOKA Motoi (30262992)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  KATO Hidehiro (30371917)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KOIZUMI Kenji (40053342)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  TANAKA Masayuki (30573414)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 20.  AMAGAI Masayuki (90212563)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  SHIMIZU Hiroshi (00146672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  NISHIKAWA Takeji (50051579)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  MINOSHIMA Shinsei (90181966)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  NAGAFUCHI Seiho (00150441)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  SAKAGUCHI Shimon (30280770)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  KUROSAKA Daijirou (20215099)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  SHIMAZU Motohide (70124948)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  FUJITA Yoko (10328106)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 29.  Fujii Takuma (10218969)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  雨宮 隆介 (60626696)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 31.  岩田 卓 (30296652)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  IWATA Takeshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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