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Asao Hironobu  浅尾 裕信

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ASAO Hironobu  浅尾 裕信

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Researcher Number 80250744
Other IDs
Affiliation (Current) 2025: 山形大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2014 – 2023: 山形大学, 医学部, 教授
2010 – 2012: 山形大学, 医学部, 教授
2003 – 2006: Yamagata University, Fuculty of Medicine, Professor, 医学部, 教授
1999 – 2002: Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授
2001: 東北大学, 大学院・医学系研究所, 助教授
1994 – 1996: 東北大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Biological Sciences / Immunology / Immunology / Basic Section 50010:Tumor biology-related / Basic Section 49070:Immunology-related / 寄生虫学(含医用動物学)
Except Principal Investigator
Immunology / Basic Section 56030:Urology-related / Virology / Immunology … More / Basic Section 49010:Pathological biochemistry-related / Urology / Tumor biology / Pediatrics Less
Keywords
Principal Investigator
サイトカイン / IL-21 / サイトカイン情報伝達 / TNF-α / Grf40 / Smad / Hrs / Hgs / アポトーシス / STAM … More / アロマターゼ / 乳癌 / 抗腫瘍免疫 / ADAM / ADAM17 / IL-12 / hepatic granuloma / neutrophil / S.Mansoni / サイトカイン産生 / 肝肉芽腫瘍手形成 / 好中球枯渇 / cマウス / BALB / 肝肉芽腫 / 好中球 / マンソン住血吸虫 / signal transduction / Grb2 family / TCR / Gads / Gbr2 / LAT / SLP76 / T細胞受容体情報伝達 / 炎症性腸疾患 / 炎症性発癌 / AID / インターロイキン21 / 炎症性発がん / TH17 / 炎症性腸炎 / Ape1/Ref-1 / 自己免疫疾患 / エピジェネティクス / EGF受容体 / SMAD / HGS / T細胞特異的遺伝子欠損マウス / 2 / STAM1 / アクチビン / AMSH / 細胞内シグナル伝達 / サイトカイン受容体共通γ鎖 / IL-2受容体 / チロシンキナーゼ … More
Except Principal Investigator
OX40リガンド / 好中球 / 抗腫瘍活性 / 炎症 / 抗原提示細胞 / IL-2 / サイトカイン / 制御性T細胞 / 免疫チェックポイント阻害剤治療 / 免疫抑制活性 / 腎癌 / 膀胱癌 / MDSCs / MDSCs / BCG / CD4陽性T細胞 / OX40L / OX40 / OX40L欠損マウス / apoptosis / 慢性関節リウマチ / ヒト・パルボウイルス / 胎児水腫 / アポトーシス / シグナル伝達 / XSCID / IL-2 receptor / γ鎖 / IL-2受容体 / 免疫抑制 / 免疫寛容 / T細胞 / 末梢血 / 腎がん / 免疫チェックポイント阻害剤 / 脂肪組織 / LPS / マクロファージ / 加齢 / 活性酸素種 / リポポリサッカライド / 炎症性サイトカイン / 自然免疫 / 5-アミノレブリン酸 / メタボリックシンドローム / 慢性炎症 / インスリン抵抗性 / 糖尿病 / 腫瘍学 / 膀胱がん / 免疫学 / 癌 / マイクロアレイ解析 / マウス / IL-21 / インターロイキン(IL-)21 / 樹状細胞 / インターロイキン21 / G-band / 全ゲノムシークエンス / 5'RACE / FISH / A2M-ALK / ALK関連腫瘍 / FLIT / 新生児間質性肺腫瘍 / ALK転座 / T-cell costimulatory signals / regulatory T cells / Antigen presenting cell / CD4^+ T cell / Immunological tolerance / 自己免疫疾患 / T細胞補助刺激 / Inflammation / CD4 T cell / T cell costimulatory signal / vesicle trafficking / Cytokine / TCR / IL-7 / STAM / 自己免疫 / 蛋白分解 / 小胞輸送 / Hrs / STAMs / γc鎖 / 抗原提示 / 炎症反応 / T細胞補助シグナル / 細胞内小胞輸送 / Inflammatory bowel disease / Interstitial pneumonia / CD4^+ T cells / OX40L-transgenic mice / 自己免疫病 / 抗DNA抗体 / IBD / 間質性肺炎 / OX40L導入マウス / G2 arrest / non-immune hydrops fetalis / NS1 / transgenic mice / Human parvovirus B19 / 細胞周期制御 / NS1非構造蛋白分子 / Experimental autoimmune encephalomyelitis (EAE) / OX40L-deficient mice / OX40 ligand / Leishmania Major感染症 / 実験的自己免疫性脳脊髄炎 / hydrops fetalis / rheumatoid arthritis / parvovirus / 非免疫性胎児水腫 / 伝染性紅斑 / 転写活性化因子 / リウマチ / パルボウイルス / knockout mice / tyrosine kinase / T cell differntiation and growth / cytokine / interleukin 2 (IL-2) / JAK1,3 / γ鎖ノックアウトマウス / サイイトカイン / インターロイキン2 (IL-2) / ノックアウトマウス / チロシンキナーゼ / T細胞分化増殖 / インターロイキン2(IL-2) / Transplantation immunity / Monoclonal antibody / Immune suppression / 増殖シグナル / 可溶化型 / 免疫制御 / 移植免疫 / 単クロン抗体 / gene targetting mouse / SARA / Hgs / Smad / TGF-β Less
  • Research Projects

    (29 results)
  • Research Products

    (45 results)
  • Co-Researchers

    (24 People)
  •  インターロイキン21によるエストロゲン産生と乳がん発生機構の解明Principal Investigator

    • Principal Investigator
      浅尾 裕信
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Yamagata University
  •  Clinical application of cancer immunity-induced neutrophils and immunosuppressive neutrophils

    • Principal Investigator
      武田 裕司
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Yamagata University
  •  Search for TPO for immunotherapy using immunosuppressive neutrophils and cancer immune-promoting neutrophils

    • Principal Investigator
      Takeda Yuji
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Yamagata University
  •  A novel model of the non-obese diabetes and investigation of immune abnormality

    • Principal Investigator
      Saitoh Shinichi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Yamagata University
  •  Enhancement of anti-tumor immunity with membrane-bound interleukin 12 (IL-12)Principal Investigator

    • Principal Investigator
      ASAO Hironobu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Yamagata University
  •  Enhancement of antitumor effect of IL-21 by improving cancer microenvironment

    • Principal Investigator
      Nara Hidetoshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Ishinomaki Senshu University
      Yamagata University
  •  Establishment of separation method for immunosuppressive neutrophils and antitumor neutrophils in renal cancer and bladder cancer

    • Principal Investigator
      Takeda Yuji
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Yamagata University
  •  Identification of novel ALK rearrangements in neonates with fetal lung interstitial tumor

    • Principal Investigator
      Onoda Tadashi
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Yamagata University
  •  IL-21-induced colitis-associated colorectal cancerPrincipal Investigator

    • Principal Investigator
      Asao Hironobu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Yamagata University
  •  TH17 cell induction through IL-21-Ape1/Ref-1 pathwayPrincipal Investigator

    • Principal Investigator
      ASAO Hironobu
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Yamagata University
  •  インターロイキン21とその受容体発現に対するエピジェネティックな制御系の解析Principal Investigator

    • Principal Investigator
      浅尾 裕信
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Immunology
    • Research Institution
      Yamagata University
  •  T細胞補助刺激分子を介した調節性T細胞機能制御

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Immunological tolerance regulated by the interaction between T cell and antigen-presenting cell

    • Principal Investigator
      ISHII Naoto
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Smads活性化因子Hgs/Hrsの細胞増殖・がん化における役割Principal Investigator

    • Principal Investigator
      浅尾 裕信
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Signal transducing pathways in immune cells and immunological disorders caused by their dysfunctions

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      2002 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Functional analysis of neutrophils that infiltrated in the S.mansoni-induced hepatic granulomaPrincipal Investigator

    • Principal Investigator
      ASAO Hironobu, 渡邊 正
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      Yamagata University
  •  STAM1・STAM2二重欠損マウスにおけるT細胞分化異常の研究Principal Investigator

    • Principal Investigator
      浅尾 裕信
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Smads活性化因子Hgs/Hrsの細胞増殖がん化における役割Principal Investigator

    • Principal Investigator
      浅尾 裕信
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  新規シグナル分子"AMSH"の遺伝子欠損による脳神経特異的なアポトーシス誘導Principal Investigator

    • Principal Investigator
      浅尾 裕信
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University
  •  Smads活性化に関わるチロシンリン酸化分子Hgsの細胞増殖がん化における役割Principal Investigator

    • Principal Investigator
      浅尾 裕信
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Analysis of transgenic mice expressing human parvovirus non-stractual (NS1) protein

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Tohoku University
  •  Regulation of autoimmune diseases by OX40-OX40L interact

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Smads活性化に関わるチロシンリン酸化分子Hrsの細胞増殖がん化における役割

    • Principal Investigator
      竹下 敏一
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University
  •  Grf40, A Novel Grb2 Family Member, Is Involved in T Cell SignalingPrincipal Investigator

    • Principal Investigator
      ASAO Hironobu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Immune regulation by OX40/OX40 ligand system

    • Principal Investigator
      ISHII Naoto
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Establishment of Model Mice of Rheumatoid Arthritis by using nonstructural protein 1 (NS1) of parvovirus B19

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Tohoku University
  •  インターロイキン2受容体γ鎖欠損マウスの解析Principal Investigator

    • Principal Investigator
      浅尾 裕信
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Study of mechanism of X-licombined immunodeficiency caused by mutations of the IL-2 receptor gamma chain

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Development of immunosuppressant drugs based on inhibition of IL-2 function

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      TOHOKU UNIVERSITY

All 2024 2023 2022 2021 2019 2018 2017 2016 2013 2012 2011 2010 2005 2003

All Journal Article Presentation Book

  • [Book] Mehods in Molecular Biology 1916, Pre-Clinical Models2019

    • Author(s)
      Takeda Y, Asao H, Wakabayashi I.
    • Total Pages
      343
    • Publisher
      Springer
    • ISBN
      9781493989935
    • Data Source
      KAKENHI-PROJECT-17K11122
  • [Book] IL-21レセプターからのシグナル伝達分子2013

    • Author(s)
      浅尾裕信
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-22590432
  • [Journal Article] Initial Myeloid Cell Status Is Associated with Clinical Outcomes of Renal Cell Carcinoma2023

    • Author(s)
      Saima Sabrina, Yuji Takeda, Tomoyuki Kato, Sei Naito, Hiromi Ito, Yuki Takai, Masaki Ushijima, Takafumi Narisawa, Hidenori Kanno, Toshihiko Sakurai, Shinichi Saitoh, Akemi Araki, Norihiko Tsuchiya and Hironobu Asao
    • Journal Title

      Biomedicines

      Volume: 11 Issue: 5 Pages: 1296-1296

    • DOI

      10.3390/biomedicines11051296

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09554, KAKENHI-PROJECT-22K09440, KAKENHI-PROJECT-23K08751
  • [Journal Article] Five Patterns of Cell Signaling Associated with Cell Behavior2022

    • Author(s)
      akeda Yuji, Kawano Kazuharu, Ma Rui, Saitoh Shinichi, Asao Hironobu
    • Journal Title

      山形大学紀要. 医学 : 山形医学 = Bulletin of the Yamagata University. Medical science : Yamagata medical journal

      Volume: 40 Issue: 1 Pages: 1-20

    • DOI

      10.15022/00005304

    • NAID

      120007193319

    • URL

      https://yamagata.repo.nii.ac.jp/records/5379

    • Year and Date
      2022-02-22
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09554
  • [Journal Article] GPI-80 Augments NF-κB Activation in Tumor Cells2021

    • Author(s)
      Takeda Yuji、Kurota Yuta、Kato Tomoyuki、Ito Hiromi、Araki Akemi、Nara Hidetoshi、Saitoh Shinichi、Tanaka Nobuyuki、Tsuchiya Norihiko、Asao Hironobu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 21 Pages: 12027-12027

    • DOI

      10.3390/ijms222112027

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07380, KAKENHI-PROJECT-19K09704, KAKENHI-PROJECT-20K08580, KAKENHI-PROJECT-20K09554
  • [Journal Article] IL-21 Enhances the Development of Colitis-Associated Colon Cancer: Possible Involvement of Activation-Induced Cytidine Deaminase Expression2019

    • Author(s)
      Araki Akemi、Jin Lianjin、Nara Hidetoshi、Takeda Yuji、Nemoto Nobuhito、Gazi Md Yeashin、Asao Hironobu
    • Journal Title

      The Journal of Immunology

      Volume: 202 Issue: 11 Pages: 3326-3333

    • DOI

      10.4049/jimmunol.1800550

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07153
  • [Journal Article] GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma2019

    • Author(s)
      Tomoyuki Kato, Yuji Takeda, Hiromi Ito, Yuta Kurota, Atsushi Yamagishi, Toshihiko Sakurai, Sei Naito, Akemi Araki, Hidetoshi Nara, Hironobu Asao, Norihiko Tsuchiya
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 249 Issue: 3 Pages: 203-212

    • DOI

      10.1620/tjem.249.203

    • NAID

      130007751389

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09704, KAKENHI-PROJECT-17K11122
  • [Journal Article] Augmentation of the expression of the eotaxin receptor on duodenal neutrophils by IL-212018

    • Author(s)
      Takeda Yuji、Kato Tomoyuki、Nemoto Nobuhito、Araki Akemi、Gazi Mohammad Yeashin、Nara Hidetoshi、Asao Hironobu
    • Journal Title

      Cytokine

      Volume: 110 Pages: 194-203

    • DOI

      10.1016/j.cyto.2018.05.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07153, KAKENHI-PROJECT-17K11122
  • [Journal Article] nterleukin-21 attenuates FITC-induced contact hypersensitivity response via regulation of dendritic cell function2018

    • Author(s)
      Nara H, Komatsu M, TekedaY, Araki A, Akhter N, Asao H
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 印刷中 Issue: 10 Pages: 2174-2184

    • DOI

      10.1016/j.jid.2018.03.1508

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07153
  • [Journal Article] Systemic neutrophil migration and rapid consumption of neutrophils in the spleen2018

    • Author(s)
      Takeda Yuji、Kato Tomoyuki、Nemoto Nobuhito、Araki Akemi、Gazi Mohammad Yeashin、Nara Hidetoshi、Asao Hironobu
    • Journal Title

      Data in Brief

      Volume: 20 Pages: 680-682

    • DOI

      10.1016/j.dib.2018.08.090

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07153
  • [Journal Article] Analysis of signal transducers using flow cytometry is useful for detection of contractive and fluctuating signals2017

    • Author(s)
      Takeda Y, Nara H, Asao H.
    • Journal Title

      Bulletin of the Yamagata University. Medical science : Yamagata medical journal

      Volume: 35 Pages: 21-32

    • NAID

      120006334923

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11122
  • [Journal Article] Role of Interleukin-21 isoform in dextran sulfate sodium (DSS)-inducedcolitis2013

    • Author(s)
      Araki A, Nara H, Rahman M, Onoda T, Li J, Juliana FM, Jin L, Murata K, Takeda Y and Asao H
    • Journal Title

      Cytokine

      Volume: 62 Issue: 2 Pages: 262-271

    • DOI

      10.1016/j.cyto.2013.03.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590432
  • [Journal Article] IL-21 isoform is a membrane-bound ligand and activatesdirectly interacted cells2013

    • Author(s)
      Nara H, Rahman M, Araki A, Jin L, Takeda Y and Asao H
    • Journal Title

      Cytokine

      Volume: 61 Issue: 2 Pages: 656-663

    • DOI

      10.1016/j.cyto.2012.12.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590432
  • [Journal Article] Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway2012

    • Author(s)
      Juliana FM, Nara H, Onoda T, Rahman M, Araki A, Jin L, Fujii H, Tanaka N, Hoshino T and Asao H
    • Journal Title

      Biochem. Biophys. Res.Commun

      Volume: 420 Issue: 3 Pages: 628-634

    • DOI

      10.1016/j.bbrc.2012.03.051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590432, KAKENHI-PUBLICLY-23114707, KAKENHI-PROJECT-23590569
  • [Journal Article] WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor2011

    • Author(s)
      Nara H, Onoda T, Rahman M, Araki A, Juliana FM, Tanaka N and Asao H
    • Journal Title

      Cell Immunol

      Volume: 269 Issue: 1 Pages: 54-59

    • DOI

      10.1016/j.cellimm.2011.03.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590432, KAKENHI-PROJECT-22591925
  • [Journal Article] Regulation of interleukin-21 receptor expression and its signal transduction by WSB-22010

    • Author(s)
      Nara H, Onoda T, Rahman M, Araki A, Juliana FM, Tanaka N and Asao H
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 392 Issue: 2 Pages: 171-177

    • DOI

      10.1016/j.bbrc.2010.01.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590432
  • [Journal Article] Hrs, a mammalian master molecule in vesicular transport and protein-sorting, suppresses the degradation of ESCRT proteins STAM1 and STAM2.2005

    • Author(s)
      Kobayashi, H., Tanaka, N., Asao, H., Miura, S., Kyuuma, M., Semura, K., Ishii, N., Sugamura K.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 10468-10477

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif.2003

    • Author(s)
      Kikuchi, K., Ishii, N., Asao, H., Sugamura, K.
    • Journal Title

      Biochem.Biophys.Res.Commun. 306

      Pages: 637-643

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.2003

    • Author(s)
      Kanazawa, C., Morita, E., Yamada, M., Ishii, N., Miura, S., Asao, H., Yoshimori, T., Sugamura, K.
    • Journal Title

      Biochem.Biophys.Res.Commun. 309

      Pages: 848-856

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Presentation] IL-21 isoform transgenic mice spontaneously develop mammary tumors2024

    • Author(s)
      Akemi Araki, Shinichi Saitoh, Yuji Takeda, Saima Sabrina, Risako Yamaguchi, Mikako Nagashima, Yusuke Nouchi, Hironobu Asao
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-23K06606
  • [Presentation] Initial myeloid cell status is associated with clinical outcomes of renal cell carcinoma2024

    • Author(s)
      Saima Sabrina, Yuji Takeda, Tomoyuki Kato, Shinichi Saitoh, Akemi Araki, Mikako Nagashima, Hidetoshi Nara, and Hironobu Asao
    • Organizer
      The 52th Annual Meeting of the Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-23K08751
  • [Presentation] IL-21 isoform transgenic mice spontaneously develop breast cancer2024

    • Author(s)
      Akemi Araki, Shinichi Saitoh, Yuji Takeda, Naing Ye Aung, Masahiro Yamamoto, Saima Sabrina, Risako Yamaguchi, Mikako Nagashima, Yusuke Nouchi, Mitsuru Futakuchi, Hironobu Asao
    • Organizer
      The 52th Annual Meeting of the Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-23K08751
  • [Presentation] 好中球の活性化パターンは、シグナル伝達分子の変動係数と関連する:シミュレーションによる細胞挙動の検証2023

    • Author(s)
      武田裕司、大和田真帆、Sabrina Saima、野内雄介、永嶋美華子、荒木明美、斉藤真一、浅尾裕信
    • Organizer
      第34回日本生体防御学会
    • Data Source
      KAKENHI-PROJECT-23K08751
  • [Presentation] 5-アミノレブリン酸生合成不全マウスは炎症反応性が低下する2022

    • Author(s)
      斉藤真一、武田裕司、Koen van Wijk、岡野聡、中島修、浅尾裕信
    • Organizer
      第10回ポルフィリン-ALA学会年会
    • Data Source
      KAKENHI-PROJECT-19K07380
  • [Presentation] MDSCs function analysis as a prediction of therapeutic effect for patients with advanced renal cell carcinoma2022

    • Author(s)
      Saima S, Kato T, Takeda Y, Naito S, Ito H, Takai Y, Ushijima M, Ozawa M, Narisawa T, Kanno H, Sakurai T, Tsuchiya N, and Asao H
    • Organizer
      第81回日本癌学会
    • Data Source
      KAKENHI-PROJECT-20K09554
  • [Presentation] The role of GPI-80 as a predicting marker of the therapeutic efficacy during immune checkpoint inhibition therapy in advanced renal cell carcinoma patients2022

    • Author(s)
      Sabrina S, Takeda Y, Kato T, Naito S, Ito H, Takai Y, Narisawa T, Kanno H, Sakurai T, Shinichi S, Akemi A, Tsuchiya N, and Asao H
    • Organizer
      第74回 日本細菌学会東北支部会 学術集会
    • Data Source
      KAKENHI-PROJECT-20K09554
  • [Presentation] Anti-tumor response during intravesical immunotherapy with BCG for non-muscle invasive bladder cancer2021

    • Author(s)
      Takeda Y, Kato T, Shinichi S, Akemi A, Asao H
    • Organizer
      第50回日本免疫学会
    • Data Source
      KAKENHI-PROJECT-20K09554
  • [Presentation] 5-aminolevulinic acid (5-ALA) synthesis deficient mice display an immune abnormality and reduced cytokine release2021

    • Author(s)
      Saitoh S, Takeda Y, van Wijk K, Nakajima O, Asao H.
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K07380
  • [Presentation] Heterogeneity of neutrophils in renal cell and urothelial carcinoma patients during immune checkpoint inhibition therapy2021

    • Author(s)
      Saima S, Kato T, Takeda Y, Naito S, Ito H, Takai Y, Ushijima M, Ozawa M, Narisawa T, Kanno H,Sakurai T, Tsuchiya N, Asao H
    • Organizer
      第80回日本癌学会
    • Data Source
      KAKENHI-PROJECT-20K09554
  • [Presentation] 5-アミノレブリン酸(5-ALA)生合成不全マウスにおける非肥満型インスリン抵抗性の発症と免疫応答・サイトカイン産生能の低下2021

    • Author(s)
      斉藤真一、武田裕司、Koen van Wijk、中島修、浅尾裕信
    • Organizer
      第85回日本インターフェロン・サイトカイン学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07380
  • [Presentation] 膀胱癌BCG膀胱内注入治療時に出現する抗腫瘍型好中球の同定2021

    • Author(s)
      武田裕司, 加藤智幸, Sabrina Saima, 内藤整, 伊藤裕美, 牛島正毅, 成澤貴史, 黒田悠太, 菅野秀典, 斉藤真一, 土谷順彦, 浅尾裕信
    • Organizer
      山形大学医学部実験動物セミナー・第32回研究成果発表会
    • Data Source
      KAKENHI-PROJECT-20K09554
  • [Presentation] Function of GPI-80 on prostate cancer cell line, PC3 cells2019

    • Author(s)
      Takeda Yuji, Kurota Yuta, Kato Tomoyuki, Araki Akemi, Saitoh Shinichi, and Asao Hironobu:
    • Organizer
      第48回日本免疫学会
    • Data Source
      KAKENHI-PROJECT-17K11122
  • [Presentation] Immune abnormality in 5-aminolevulinic acid (ALA) synthesis deficient mice, which is a novel model of the non-obese diabetes2019

    • Author(s)
      Saitoh Shinichi, Takeda Yuji, Wijk Koen van, Kimura Tomohiro, Okano Satoshi, Nakajima Osamu, and Hironobu Asao
    • Organizer
      The 7th International ALA and Porphyrin Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07380
  • [Presentation] Myeloid cell heterogeneity indicating appearance of myeloid derived suppressor cells (MDSCs)in peripheral blood of metastatic renal cell carcinoma (mRCC)2019

    • Author(s)
      Tomoyuki Kato, Yuji Takeda, Yuta Kurota, Sei Naito, Hiromi Ito, Akemi Araki, Hironobu Asao, Norihiko Tsuchiya
    • Organizer
      ASCO GU-Genitourinary Cancers Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11122
  • [Presentation] 5-ALA生合成不全マウスにおける非肥満型糖尿病モデルの検討と免疫異常の解析2019

    • Author(s)
      斉藤真一、荒木明美、武田裕司、Koen van Wijk、木村朋寛、岡野聡、中島修、浅尾裕信
    • Organizer
      第42回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-19K07380
  • [Presentation] IL-21isoform過剰発現マウスにおける高脂肪食性肥満の抑制と脂肪組織異常2019

    • Author(s)
      斉藤真一、荒木明美、武田裕司、浅尾裕信
    • Organizer
      第73回日本細菌学会東北支部総会
    • Data Source
      KAKENHI-PROJECT-19K07380
  • [Presentation] ALA生合成不全マウ糖代謝異常の分子機構解析2019

    • Author(s)
      斉藤真一、武田裕司、Koen van Wijk、木村朋寛、岡野聡、尾崎司、浅尾裕信、中島修
    • Organizer
      第9回ポルフィリン-ALA学会年会
    • Data Source
      KAKENHI-PROJECT-19K07380
  • [Presentation] Increased Development of Colitis-Associated Colon Cancer in IL-21-isoform transgenic mice: Possible Involvement of Activation-Induced Cytidine Deaminase Expression2019

    • Author(s)
      Araki Akemi, Jin Lianjin, Nara Hidetoshi, Takeda Yuji, Saitoh Shinichi, Nemoto Nobuhito, Md Yeashin Gazi, and Asao Hironobu
    • Organizer
      第48回日本免疫学会
    • Data Source
      KAKENHI-PROJECT-19K07380
  • [Presentation] Analysis of urinary leukocytes during intravesical immunotherapy with BCG for non-muscle invasive bladder cancer2018

    • Author(s)
      Takeda Yuji, Kato Tomoyuki, Kurota Yuta, Ito Hiromi, Akemi Araki, Tsuchiya Norihiko, and Asao Hironobu
    • Organizer
      第77回日本癌学会
    • Data Source
      KAKENHI-PROJECT-17K11122
  • [Presentation] Interleukin21 arrests bone marrow derived dendritic cells PD-L1 high immunosuppressive state2017

    • Author(s)
      Nara H, TAKEDA Y, Md. GAZI Y, NEMOTO N, ARAKI A, ASAO H.
    • Organizer
      第46回 日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K07153
  • [Presentation] GPI-80, a useful marker of MDSC in mRCC patients, is a reference for the search for new MDSC markers2017

    • Author(s)
      Tomoyuki Kato, Yuji Takeda, Hitomi Ito, Yuta Kurota, Mayu Yagi, Toshihiko Sakurai, Sei Naito, Hisashi Kawazoe, Osamu Ichiyanagi, Norihiko Tsuchiya, Hironobu Asao
    • Organizer
      第76回日本癌学会
    • Data Source
      KAKENHI-PROJECT-17K11122
  • [Presentation] 転移性腎細胞癌患者における末梢血中GPI-80発現は予後因子となりうる2017

    • Author(s)
      加藤智幸,武田裕司,伊藤裕美,黒田悠太,奈良英利,櫻井俊彦,西田隼人,内藤整,川添久,荒木明美,一柳統,浅尾裕信,土谷順彦
    • Organizer
      第55回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K11122
  • [Presentation] 慢性炎症から発がんへのメカニズム解析 -大腸がん誘導マウスを用いて-2016

    • Author(s)
      荒木明美, 金蓮今, 奈良英利, 武田裕司, 浅尾裕信
    • Organizer
      日本細菌学会東北支部総会
    • Place of Presentation
      北里大学獣医学部、十和田市
    • Year and Date
      2016-08-19
    • Data Source
      KAKENHI-PROJECT-26460568
  • [Presentation] Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction throughERK1/2pathway2011

    • Author(s)
      Hironobu Asao
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      千葉幕張メッセ
    • Year and Date
      2011-11-29
    • Data Source
      KAKENHI-PROJECT-22590432
  • [Presentation] Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway2011

    • Author(s)
      Hironobu Asao, et al.
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      千葉幕張メッセ
    • Year and Date
      2011-11-29
    • Data Source
      KAKENHI-PROJECT-22590432
  • 1.  ISHII Naoto (60291267)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 3 results
  • 2.  NARA Hidetoshi (00375338)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 14 results
  • 3.  Takeda Yuji (90302299)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 31 results
  • 4.  SUGAMURA Kazuo (20117360)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 5.  Saitoh Shinichi (90536674)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 15 results
  • 6.  ASAO Naoki (60241519)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 7.  TANAKA Nobuyuki (60280872)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  竹下 敏一 (60212023)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  加藤 智幸 (40396560)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 10.  SATOMI Susumu (00154120)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  SASAKI Takeshi (50110656)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KASAI Noriyuki (60001947)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KONNO Tasuke (00004846)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Onoda Tadashi (10582562)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  仁木 賢 (60241626)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  大保 和之 (70250751)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  森田 英嗣 (70344653)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  渡邊 正 (60113990)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  荒木 慶彦 (70250933)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  黒田 悠太 (00594326)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 21.  土谷 順彦 (70282176)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 22.  中島 修 (80312841)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 23.  内藤 整 (00431643)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  ARAKI AKEMI
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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