Ohnishi Kazunori 大西一功

… Alternative Names

OHNISHI Kazunori 大西一功

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Researcher Number	80252170
Other IDs
External Links
Affiliation (Current)	2025: 修文大学, 医療科学部, 教授
Affiliation (based on the past Project Information) *help	2014: 浜松医科大学, 医学部付属病院, 教授 2005 – 2014: 浜松医科大学, 医学部附属病院, 教授 2010: 浜松医科大学, 医学部付属病院, 教授 2008: 浜松医科大学, 医学部・附属病院, 教授 2007: 浜松医科大学, 医学部付属病院, 教授 … More 2004: Hamamatsu Univ.Sch.Med., Faculty of Med, Associate Professor, 医学部, 助教授 2001 – 2004: School of Medicine, Hamamatsu University School of Medicine Associate professor, 医学部, 助教授 1999 – 2000: Hamamatsu University School of Medicine III, the Attached Hospital, Assistant Professor, 医学部・附属病院, 講師 1998: 浜松医科大学, 医学部附属病院, 講師 1996: Hamamatsu University School of Medicine, Assistant Professor, 医学部附属病院, 講師 1995 – 1996: 浜松医科大学, 医学部・附属病院, 講師 1994 – 1995: 浜松医科大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Hematology / Hematology / Biological Sciences Except Principal Investigator Laboratory medicine / Hematology / Tumor diagnosis / Hematology / Cerebral neurosurgery / Biological Sciences
Keywords	Principal Investigator 急性骨髄性白血病 / Bcr-Abl gene / PI3K inhibitor / colony assay / Chronic myelogenous leukemia / Abl kinase inhibitor / 医療・福祉 / シグナル伝達 / 遺伝子 / 薬剤反応性 … More / 癌 / Bcr-Abl遺伝子 / Ablキナーゼ阻害剤 / Bcr-Ab1遺伝子 / PI3K阻害剤 / コロニーアッセイ / 慢性骨髄性白血病 / Ab1キナーゼ阻害剤 / SH-PTP1 / granulocytic differentiation / retroviral vector / granulocyte colony-stimulating factor receptor / gene therapy / myelodysplastic syndrome / トロンポボエチン受容体遺伝子 / エリスロポエチン受容体遺伝子 / チロシンリン酸化酵素 / 遺伝子導入 / 分化誘導 / 情報伝達経路 / レトロウイルスベクター / 顆粒球コロニー刺激因子受容体遺伝子 / 遺伝子治療 / 骨髄異形成症候群 / Antisense nucleotide / myeloid differentiation / Acute myeloid leukemia / Homeobox Box gene / 骨髄性白血病 / ホメオボックス遺伝子 / 急性骨髄性白血病細胞株 / アンチセンス核酸 / レチノイン酸 / 細胞分化 / ホメオボックスB遺伝子 / 代謝阻害剤 / 嫌気性代謝 / 白血病幹細胞 / 代謝酵素阻害剤 / 白血病幹/前駆細胞 / 代謝制御 / メタボローム解析 / 白血病 / ヒト化抗CD33抗体 / ATRA耐性 / 亜砒酸 / 急性前骨髄球性白血病 / タミバロテン / 多剤耐性 / CMA676 … More Except Principal Investigator CD34 / 急性前骨髄球性白血病 / 薬剤耐性 / CD33 / mpl / NB4 / IIIa / CD38 / thrombopoietin receptor / erythropoietin receptor / MDS / acute promyelocytic leukemia / 急性白血病 / Am-80 / As_2O_3 / all-trans retinoic acid / 受容体 / 糖鎖 / フローサイトメトリー / ホルモン / P糖蛋白質 / carbohydrate chain / flow cytometry / thyrotropin / hormone / receptor / cytokine / 造血因子 / フローサトメトリー / 甲状腺刺激ホルモン / サイトカイン / P glycoprotein / drug resistance / target oriented therapy / monoclonal antibody / minimal residual disease / acute myeloid leukemia / 耐性克服剤 / P糖タンパク / 分子標的療法 / モノクーローナル抗体 / 微小残存病変 / 急性骨髄性白血病 / P-glycoprotein / All-trans Retinoic Acid (ATRA)-Resistance / Acute Promyelocytic Leukemia / 全トランス型レチノイン酸 / P糖蛋白 / 全トランス型レチノイン酸耐性 / glycoprotein IIb / glycophorin A / Glycophorin-A / エリスロポイエチンレセプター / Glycoprotein IIb / Glycophorin A / 骨髄異形成症候群 / cytoplasmic retinoic acid binding protein / retinoid / apoptosis / PML / Vitamin A / RAR遺伝子 / PML遺伝子 / 分子生物学 / レチノイン酸 / アポトーシス / 癌瘍1号-713 / PML-RARαキメラ遺伝子 / 分化誘導療法 / 蛍光標識 / 細胞分離 / 蛍光染色 / がん幹細胞 / 核酸 / 薬効評価と予測 / 薬物評価と予測 / 腫瘍診断学 / チロシンキナーゼ阻害剤 / BCR-ABL1遺伝子点突然変異 / BCR-ABL1点突然変異解析 / イマチニブ / PCR-インベーダー法 / BCR-ABL1点突然変異 / 慢性骨髄性白血病 / 肝細胞 / Kras / bcr-abl / 白血病細胞 / 癌細胞 / KRAS / FRET法 / 幹細胞 / 白血病 / mRNA / cell sorter / エネルギー移行 / ビオチン化 / TSH / 蛋白質 / 薬理学 / 糖化合物 / シグナル伝達 / 癌 / mesenchvmal stem cell / glioma / bystander effect / brain tumor / mesenchymal stem cell / neural stem cell / ganciclovir / herpes simplex virus-thymidine kinase / gene therapy / 脳腫瘍学 / 抗体療法 Less

BCR-ABL1 mutations in patients with imatinib-resistant chronic myelogenous leukemia
- Principal Investigator
  
  ONO TAKAAKI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnosis
- Research Institution
  Hamamatsu University School of Medicine
Isolation of cancer stem cells by the staining nucleic acid and analyses of their molecular specificities
- Principal Investigator
  
  TAKESHITA Akihiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Hamamatsu University School of Medicine
The metabolome analysis of leukemic stem cellPrincipal Investigator
- Principal Investigator
  
  OHNISI Kazunori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine
A functional quantitative receptor assay using flluoscein labeled hormones with a carbohydrate chain for the evaluation of the hormonal replacement therapy
- Principal Investigator
  
  ONO Takaaki, TAKESHITA Kaori (新庄香)
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Hamamatsu University School of Medicine
Utility of separation technique of live cancer stem cells with using an energy transfer fluorescence probes
- Principal Investigator
  
  TAKESHITA Akihiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Hamamatsu University School of Medicine
Development of phosphor sugar derivatives for hematological malignancy therapy
- Principal Investigator
  
  NAKAMURA Satoki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine
Use of mesenchymal stem cells as a vector for glioma gene therapy
- Principal Investigator
  
  NAMBA Hiroki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hamamatsu University School of Medicine
Anon-isotopic quantitative receptor assay using biotinylation of ligands and hormones with a carbohydrate chain
- Principal Investigator
  
  TAKESHITA Kaori
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Hamamatsu University School of Medicine
Research for eradication of CML stem/progenitor cells which resisted Abl kinase inhibitorsPrincipal Investigator
- Principal Investigator
  
  OHNISHI Kazunori
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine
Enhancement of purging for minimal residual disease by anti-CD33 monoclonal antibody and multidrug resistant modifiers
- Principal Investigator
  
  TAJKESHITA Akihiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine
急性前骨髄球性白血病の薬剤耐性例に対する砒素標識ヒト化抗体の有効性と砒素毒性の軽減
- Principal Investigator
  
  竹下明裕
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
白血病における分子標的療法の至適臨床応用と併用による効果増強に関する研究Principal Investigator
- Principal Investigator
  
  大西一功
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
Retrovirus-mediated gene transfer of hematopoietic stimulating factor receptor cDNA into MDS cells and gene therapyPrincipal Investigator
- Principal Investigator
  
  OHNISHI Kazunori
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine
Study of Resistance Mechanisms of All-trans Retinoic Acid in Acute Promyelocytic Leukemia
- Principal Investigator
  
  TAKESHITA Akihiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine
Cytokine receptor expression and gene in myelodysplastic syndromes.
- Principal Investigator
  
  OHNO Ryuzo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine
Homeobox B genes expression in human leukemia cell lines during myelomonocytic differentiationPrincipal Investigator
- Principal Investigator
  
  OHNISHI Kazunori
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine
Differentiation therapy of acute promylocytic leukemia.
- Principal Investigator
  
  OHNO Ryuzo, 大野龍三
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Hamamatsu Univ.

All 2014 2013 2012 2011 2010 2009 2004 2003 2002 Other

All Journal Article Presentation Book

[Book] 癌と化学療法慢性骨髄性白血病に対するイマチニブ治療-10年を振り返り-2011
- Author(s)
  大西一功
- Total Pages
  3
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-21590621
[Book] 癌と化学療法慢性骨髄性白血病に対するイマチニブ治療-10年を振り返り-2011
- Author(s)
  大西一功
- Total Pages
  3
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-21590621
[Book] 癌と化学療法高齢者のがん薬物療法-血液-2011
- Author(s)
  大西一功
- Total Pages
  5
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-21590621
[Book] 癌と化学療法高齢者のがん薬物療法-血液-2011
- Author(s)
  大西一功
- Total Pages
  5
- Publisher
  癌と化学療法社
- Data Source
  KAKENHI-PROJECT-21590621
[Journal Article] Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA ligase IV transcription of daunorubicin-resistant leukemia cell lines.2014
- Author(s)
  Nishida Y, Mizutani N, Inoue M, Omori Y, Tamiya-Koizumi K, Takagi A, Kojima T, Suzuki M, Nozawa Y, Minami Y, Ohnishi K, Naoe T, Murate T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1839 Issue: 4 Pages: 265-274
- DOI
  10.1016/j.bbagrm.2014.02.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591379, KAKENHI-PROJECT-25461412, KAKENHI-PROJECT-26290051, KAKENHI-PROJECT-26670625
[Journal Article] Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients.2014
- Author(s)
  Tashiro M, Naito T, Ohnishi K, Kagawa Y, Kawakami J.
- Journal Title
  
  Clin Chim Acta.
  
  Volume: 429 Pages: 175-180
- DOI
  10.1016/j.cca.2013.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591379, KAKENHI-PROJECT-23790181, KAKENHI-PROJECT-25460215
[Journal Article] The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts.2013
- Author(s)
  Ohnishi K
- Journal Title
  
  Blood
  
  Volume: 121 Issue: 22 Pages: 4439-42
- DOI
  10.1182/blood-2013-03-490003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591379, KAKENHI-PUBLICLY-25130712
[Journal Article] Cancer cachexia raises the plasma concentration of oxymorphone through the reduction of CYP3A but not CYP2D6 in oxycodone-treated patients.2013
- Author(s)
  Naito T, Tashiro M, Ishida T, Ohnishi K, Kawakami J.
- Journal Title
  
  J Clin Pharmacol.
  
  Volume: 53 Issue: 8 Pages: 812-818
- DOI
  10.1002/jcph.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591379
[Journal Article] Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97.2013
- Author(s)
  Fujita H, Asou N, Iwanaga M, Hyo R, Nomura S, Kiyoi H, Okada M, Inaguma Y, Matsuda M, Yamauchi T, Ohtake S, Izumi T, Nakaseko C, Ishigatsubo Y, Shinagawa K, Takeshita A, Miyazaki Y, Ohnishi K, Miyawaki S, Naoe T; Japan Adult Leukemia Study Group.
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Issue: 10 Pages: 1339-1345
- DOI
  10.1111/cas.12230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501307, KAKENHI-PROJECT-23590694, KAKENHI-PROJECT-23591379, KAKENHI-PROJECT-23591396, KAKENHI-PROJECT-24590688, KAKENHI-PROJECT-24591387
[Journal Article] Long-term outcome of imatinib therapy, with assessment of its dosage and blood levels, for chronic myelogenous leukemia2012
- Author(s)
  Ohnishi K., et al
- Journal Title
  
  Cancer Science
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621
[Journal Article] Long-term outcome of imatinib therapy, with assessment of its dosage and blood levels, for chronic myelogenous leukemia2012
- Author(s)
  Ohnishi K, et al
- Journal Title
  
  Cancer Science
  
  Volume: (In press) Issue: 6 Pages: 1071-1078
- DOI
  10.1111/j.1349-7006.2012.02253.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621, KAKENHI-PROJECT-21591198, KAKENHI-PROJECT-24591387
[Journal Article] Recovery of Kidney Function by Rituximab-based Therapy in a Patient with Waldenström's Macroglobulinemia-related Nephropathy Presenting Cast Nephropathy and Interstitial Lymphocytic Infiltration2012
- Author(s)
  Miwa M, Sakao Y, Ishigaki S, Ono M, Fujikura T, Yasuda H, Suzuki H, Kato A, Nagata Y, Shigeno K, Nakamura S, Ohnishi K, Fujigaki Y
- Journal Title
  
  Intern. Med.
  
  Volume: 51 Issue: 13 Pages: 1725-1730
- DOI
  10.2169/internalmedicine.51.7207
- NAID
  130002062195
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591379
[Journal Article] Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression2012
- Author(s)
  Nakamura S, Yokota D, Tan L, Nagata Y, Takemura T, Hirano I, Shigeno K, Shibata K, Fujisawa S, Ohnishi K
- Journal Title
  
  Int J Cancer
  
  Volume: 130(5) Issue: 5 Pages: 1046-1059
- DOI
  10.1002/ijc.26065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591379
[Journal Article] Phase I trial of gemtuzumab ozogamicin in intensive combination chemotherapy for relapsed or refractory adult acute myeloid leukemia(AML): Japan Adult Leukemia Study Group(JALSG)-AML206 study2011
- Author(s)
  Usui N, Ohnishi K., et al
- Journal Title
  
  Cancer Science
  
  Volume: 102(7) Pages: 1358-65
- NAID
  10029295449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621
[Journal Article] for the Japan Adult Leukemia Study Group. Phase I trial of gemtuzumab ozogamicin in intensive combination chemotherapy for relapsed or refractory adult acute myeloid leukemia(AML): Japan Adult Leukemia Study Group(JALSG)-AML206 study2011
- Author(s)
  Usui N, Takeshita A, Nakaseko C, Dobashi N, Fujita H, Kiyoi H, Kobayashi Y, Sakura T, Yahagi Y, Shigeno K, Ohwada C, Miyazaki Y, Ohtake S, Miyawaki S, Naoe T, Ohnishi K
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 1358-1365
- Data Source
  KAKENHI-PROJECT-21590622
[Journal Article] JmjC-domain containing histone demethylase 1B-mediated p15(Ink4b) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia2011
- Author(s)
  Nakamura S, Ohnishi K., et al
- Journal Title
  
  Molecular Carcinogenesis
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621
[Journal Article] Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia2011
- Author(s)
  Nakamura S, Ohnishi K, et al
- Journal Title
  
  PLoS One
  
  Volume: 6(11) Issue: 11 Pages: e28011-e28011
- DOI
  10.1371/journal.pone.0028011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621, KAKENHI-PROJECT-21650108, KAKENHI-PROJECT-23591379
[Journal Article] Nilotinib as frontline therapy for patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase : results from the Japanese subgroup of ENESTnd2011
- Author(s)
  Nakamae H, Shibayama H, Kurokawa M, Fukuda T, Nakaseko C, Kanda Y, Nagai T, Ohnishi K, Maeda Y, Matsuda A, Amagasaki T, Yanada M
- Journal Title
  
  International Journal of Hematology
  
  Volume: 93 Issue: 5 Pages: 624-632
- DOI
  10.1007/s12185-011-0841-8
- NAID
  10029535125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679004, KAKENHI-PROJECT-21590621
[Journal Article] Phase I trial of gemtuzumab ozogamicin in intensive combination chemotherapy for relapsed or refractory adult acute myeloid leukemia (AML) : Japan Adult Leukemia study Group (JALSG)-AML206 study2011
- Author(s)
  Usui N, Ohnishi K, et al
- Journal Title
  
  Cancer Science
  
  Volume: 102(7) Issue: 7 Pages: 1358-65
- DOI
  10.1111/j.1349-7006.2011.01957.x
- NAID
  10029295449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621, KAKENHI-PROJECT-21590622, KAKENHI-PROJECT-21591198
[Journal Article] JmjC-domain containing histone demethylase 1B-mediated P15(Ink4b) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia2011
- Author(s)
  Nakamura S, Ohnishi K, et al
- Journal Title
  
  Molecular Carcinogenesis
  
  Volume: (In press) Issue: 1 Pages: 57-69
- DOI
  10.1002/mc.20878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621, KAKENHI-PROJECT-23591379, KAKENHI-PROJECT-25460384
[Journal Article] Nilotinib as frontline therapy for patients with newly diagnosed Ph+chronic myeloid leukemia in chronic phase : results from the Japanese subgroup of ENESTnd2011
- Author(s)
  Nakamae H, Ohnishi K., et al
- Journal Title
  
  International journal of hematology
  
  Volume: 93(5) Pages: 624-632
- NAID
  10029535125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621
[Journal Article] Bcr-Abl-mediated Raf kinase inhibitor protein suppression promotes chronic myeloid leukemia progenitor cells proliferation2011
- Author(s)
  Nakamura S, Yagyu T, Takemura T, Tan L, Nagata Y, Yokota D, Hirano I, Shibata K, Fujie M, Fujisawa S, Ohnishi K
- Journal Title
  
  SCD
  
  Volume: 1(3) Issue: 03 Pages: 54-66
- DOI
  10.4236/scd.2011.13006
- ISSN
  2161-6760, 2161-6787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591379
[Journal Article] Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells2011
- Author(s)
  Nakamura S, Takemura T, Tan L, Nagata Y, Yokota D, Hirano I, Shigeno K, Shibata K, Fujie M, Fujisawa S, Ohnishi K.
- Journal Title
  
  Carcinogenesis
  
  Volume: 32(12) Issue: 12 Pages: 1758-1772
- DOI
  10.1093/carcin/bgr205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591379
[Journal Article] Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia2011
- Author(s)
  Nakamura S, Ohnishi K., et al
- Journal Title
  
  PLoS One
  
  Volume: 6(11)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621
[Journal Article] Phase I and II study of azacitidine in Japanese patients with myelodysplastic syndromes2011
- Author(s)
  Uchida T, Ohnishi K., et al
- Journal Title
  
  Cancer Science
  
  Volume: 102(9) Pages: 1680-6
- NAID
  10030243114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621
[Journal Article] Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells2011
- Author(s)
  Nakamura S, Ohnishi K., et al
- Journal Title
  
  Carcinogenesis
  
  Volume: 32(12) Pages: 1758-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590621
[Journal Article] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity.2010
- Author(s)
  Nakamura S, Yamashita M, Yokota D, Hirano I, Ono T, Fujie M, Shibata K, Niimi T, Suyama T, Maddali K, Asai K, Yamashita J, Iguchi Y, Ohnishi K.
- Journal Title
  
  Investigational New Drugs 28(4)
  
  Pages: 381-391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591115
[Journal Article] Preparation and characterization of novel 4-bromo-3, 4-dimethyl-1-phenyl-2-phospholene 1-oxide and the analogous phosphorus heterocycles or phospha sugars.2010
- Author(s)
  Yamada M, Yamashita M, Suyama T, Yamashita J, Asai K, Niimi T, Ozaki N, Fujie M, Maddali K, Nakamura S, Ohnishi K.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters. 20(19)
  
  Pages: 5943-5946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591115
[Journal Article] Research and development of phospha sugar anti-cancer agents with anti-leukemic activity.2010
- Author(s)
  Yamashita J, Suyama T, Asai K, Yamada M, Niimi T, Fujie M, Nakamura S, Ohnishi K, Yamashita M.
- Journal Title
  
  Heterocyclic communications. 2
  
  Pages: 89-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591115
[Journal Article] The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia.2010
- Author(s)
  Nakamura S, Hirano I, Okinaka K, Takemura T, Yokota D, Ono T, Shigeno K, Shibata K, Fujisawa S, Ohnishi K.
- Journal Title
  
  Carcinogenesis. 31
  
  Pages: 2012-2021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591115
[Journal Article] CMC-544(inotuzumab ozogamicin), an anti-CD22immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells2009
- Author(s)
  Takeshita A, Yamakage N, Shinjo K, Ono T, Hirano I, Nakamura S, Shigeno K, Tobita T, Maekawa M, Kiyoi H, Naoe T, Ohnishi K, Sugimoto Y, Ohno R
- Journal Title
  
  Leukemia
  
  Volume: 23(7) Pages: 1329-36
- Data Source
  KAKENHI-PROJECT-21590622
[Journal Article] CMC-544(inotuzumab ozogamicin) shows less effect on multidrug resistant cells : analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma2009
- Author(s)
  Takeshita A, Shinjo K, Yamakage N, Ono T, Hirano I, Matsui H, Shigeno K, Nakamura S, Tobita T, Maekawa M, Ohnishi K, Sugimoto Y, Kiyoi H, Naoe T, Ohno R
- Journal Title
  
  Br J Haematol
  
  Volume: 146(1) Pages: 34-43
- Data Source
  KAKENHI-PROJECT-21590622
[Journal Article] Phenylarsine oxide (PAO) more intensely induces apoptosis in acute promyelocytic leukaemia (APL) and As_2O_3-resistant APL cell lines than As_2O_3 by activating the mitochondrial pathway.2004
- Author(s)
  Sahara N, Takeshita A, Shigeno K, Fujisawa S, Takeshita K, Naito K, Ihara M, Ono T, Tamashima S, Nara K, Ohnishi K, Ohno R.
- Journal Title
  
  Leukemia and Lymphoma. 45
  
  Pages: 987-995
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570972
[Journal Article] Impairment of heart rate variability control during arsenic trioxide treatment for acute promyelocytic leukemia.2004
- Author(s)
  Takeshita A, Uehara A, Shinjo K, Naito K, Sahara N, Yamazaki K, Katoh H, Kamikawa T, Ohnishi K, Maekawa M, Hayashi H, Ohno.
- Journal Title
  
  Leukemia 18
  
  Pages: 647-648
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570972
[Journal Article] del(6p23) and der(11p15) including NUP98 translocation in a case of secondary myeloproliferative disorder which eventually underwent clonal evolution and transformed to acute myeloid leukemia.2004
- Author(s)
  Takeshita A, Naito K, Shinjo K, Nakamura S, Sahara N, Matui H, Ohnishi K, Beppu H, Ohtsubo K, Hisatomi H, Horii T, Maekawa M, Inaba T, Ryuzo Ohno.
- Journal Title
  
  Cancer Genet Cytogenet 152
  
  Pages: 56-60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570972
[Journal Article] Disease-related potential of mutations in transcriptional cofactors CREB-binding protein and p300 in leukemias.2004
- Author(s)
  Shigeno K, Yoshida H, Pan L, Luo JM, Fujisawa S, Naito K, Nakamura S, Shinjo K, Takeshita A, Ohno R, Ohnishi K.
- Journal Title
  
  Cancer Lett. 213
  
  Pages: 11-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570972
[Journal Article] P-glycoprotein (P-gp) can be induced by arsenic trioxide (As_2O_3) therapy, but is not the main mechanism of As_2O_3-resistance in acute promyelocytic leukemia cells : analysis of P-gp and intracellular concentration of As_2O_3.2003
- Author(s)
  Takeshita A, Shinjo K, Naito K, Fujisawa S, Shigeno K, Horii T, Maekawa M, Izumi M, Kitamura K, Ohnishi K, Naoe T, Ohno R.
- Journal Title
  
  Leukemia 17
  
  Pages: 648-650
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570972
[Journal Article] Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug-resistance modifiers.2002
- Author(s)
  Matsui H, Takeshita A, Naito K, Shinjo K, Shigeno K, Maekawa M, Yamakawa Y, Tanimoto M, Kobayashi M, Ohnishi K, Ohno R.
- Journal Title
  
  Leukemia 16
  
  Pages: 813-819
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570972
[Journal Article] Efficacy of gemtuzumab ozogamicin on ATRA-and arsenic-resistant acute promyelocytic leukemia (APL) cells.
- Author(s)
  Takeshita A, Shinjo K, Naito K, Matsui H, Sahara N, Shigeno K, Horii T, Shirai N, Maekawa M, Ohnishi K, Naoe T, Ohno R.
- Journal Title
  
  Leukemia (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570972
[Presentation] CD56 expression is one of the unfavorable prognostic factors for acute promyelocytic leukemia patients: Long-term follow-up results of the Japan Adult Leukenia Study Group.2013
- Author(s)
  Takeshita A, Ono T, Ohnishi K, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Emi N, Fujita H, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Kimura Y, Iwanaga M, Asou N, Miyawaki S, Miyazaki Y, Naoe T.
- Organizer
  Promyelocytic Leukemia Symposium
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-24590688
[Presentation] Inhibition of JHDM1B expression suppresses the proliferation of leukemia cells through the cell cycle arrest2011
- Author(s)
  Lin Tan, Satoki Nakamura, Aya Asahina, Tomonari Takemura, Yasuyuki Nagata, Daisuke Yokota, Takaaki Ono, Kazuyuki Shigeno, Shinya Fujisawa, Kazunori Ohnishi
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591379
[Presentation] The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia2011
- Author(s)
  Satoki Nakamura, Tomonari Takemura, Daisuke Yokota, Isao Hirano, Takaaki Ono, Kazuyuki Shigeno, Kiyoshi Shibata, Shinya Fujisawa, Kazunori Ohnishi
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591379
[Presentation] Role of hematopoietic stem cell transplantation as salvage treatment of acute promyelocytic leukemia initially treated with all-trans retinoic acid : a retrospective analysis of the Japan Adult Leukemia Study Group(JALSG) APL97Study2011
- Author(s)
  Fujita H, Asou N, Iwanaga M, Hyo R, Nomura S, Kiyoi H, Okada M, Tsuzuki M, Matsuda M, Yamauchi T, Ohtake S, Izumi T, Nakaseko C, Mitani K, Shinagawa K, Takeshita A, Miyazaki Y, Ohnishi K, Miyawaki S, Naoe T
- Organizer
  53rd Annual Meeting of American Society of Hematology San Diego
- Place of Presentation
  CA, USA
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21590622
[Presentation] Induction of IER5 inhibits leukemia cell proliferation through modulation of cell cycle progression2011
- Author(s)
  中村悟己、竹村兼成、横田大輔、平野功、小野孝明、重野一幸、藤澤紳哉、大西一功
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591379
[Presentation] Clinical features and prognostic impact of CD56expression in acute promyelocytic leukemia : Long term follow up data from the Japan Adult Leukemia Study Group(JALSG) APL972011
- Author(s)
  Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Yagasaki F, Kimura Y, Fujita H, Iwanaga M, Asou N, Ohnishi K, Naoe T
- Organizer
  53rd Annual Meeting of American Society of Hematology San Diego
- Place of Presentation
  CA, USA
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21590622
[Presentation] Roles of RAB45-mediated p38 activation in apoptosis of CML progenitor cells2011
- Author(s)
  竹村兼成、中村悟己、横田大輔、平野功、小野孝明、重野一幸、藤澤紳哉、大西一功
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591379
[Presentation] The analysis of BCR-ABL1 mutations in imatinib-resistant Philadelphia Chromosome-positive leukemia2010
- Author(s)
  Ono T, Ohnishi K, et al
- Organizer
  72^<nd> Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-21590621
[Presentation] BCR-ABL1 mutations in Japanese patients with Ph-positive leukemia resistant to imatinib2010
- Author(s)
  Ono T, Ohnishi K, et al
- Organizer
  8^<th> Annual Meeting of Japanese Society of Medical Oncology
- Place of Presentation
  Tokyo Japan
- Year and Date
  2010-03-20
- Data Source
  KAKENHI-PROJECT-21590621
[Presentation] Internalization speed may be one of the factors in the efficacy of CMC-544(inotuzumab ozogamicin), the newly developed calicheamicin-conjugated antibody2009
- Author(s)
  Takeshita A, Shinjo K, Watanabe Y, Maekawa M, Ohnishi K, Sugimoto Y, Ohno R
- Organizer
  68th Annual Meeting of Japanese Cancer Society
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-21590622
[Presentation] Hematological malignancies : recent advances and future directions Treatment of CML in the era of molecular targeted therapy2009
- Author(s)
  Ohnishi K, et al
- Organizer
  68^<th> Annual Meeting of the Japanese Cancer Assosiation
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21590621
[Presentation] CMC-544, an anti-CD22immunoconjugate of calicheamicin, decreases the level of compliment inhibitory factors on malignant B-cell lymphoma cells2009
- Author(s)
  Takeshita A, Yamakage N, Shinjo K, Hirano I, Ono T, Fujihara H, Watanabe H, Iino K, Hashimoto D, Maekawa M, Ohnishi K, Ohno R
- Organizer
  14nd Congress of European Society of Hematology
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-21590622
[Presentation] Downregulation of THAP11 by Bcr-Abl Promotes c-Myc-Mediated CML Cell Proliferation2009
- Author(s)
  Yokota D, Ono T, Ohnishi K et al
- Organizer
  51st ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans, U. S. A
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-21590621
[Presentation] Depletion of PHLPP1, 2 by Bcr-Abl promotesCML cell proliferation through the continuousphosphorylation of Akt isoforms2009
- Author(s)
  Nakamura S, Ohnishi K, et al
- Organizer
  68^<th> Annual Meeting of the Japanese Cancer Assosiation
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21590621
[Presentation] A Phase I/II Trial of Gemtuzumab Ozogamicin in Combination with Cytarabine and Anthracyclines(Daunorubicin or Idarubicin) for CD33-Positive Refractory or Relapsed AML Patients Younger Than65Years. Results of Phase I Parts of the JALSG-AML206Study2009
- Author(s)
  Usui N, Takeshita A, Nakaseko C, Dobashi N, Fujita H, Kiyoi H, Kobayashi Y, Fujisawa S, Yagasaki F, Nishii K, Kiguchi T, Miyazaki Y, Ohtake S, Miyawaki S, Ohno R, Naoe T, Ohnishi K
- Organizer
  51st Annual Meeting of the American Society of Hematology
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-21590622
[Presentation] Depletion of PHLPP1 and 2 by Bcr-Abl Promotes CML Cell Proliferation through the Continuous Phosphorylation of Akt2009
- Author(s)
  Hirano I, Ono T, Ohnishi K et al
- Organizer
  51st ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans, U. S. A
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-21590621
[Presentation] Prognostic Impact of Chromosomal Variation in Patients with Acute Promyelocytic Leukemia (APL); Analysis of 775 Cases Enrolled in the Japan Adult Leukemia Study Group APL Studies.
- Author(s)
  Adachi M, Takeshita A, Taki T, Ohtake S, Shinagawa K, Kiyoi H, Matsuda M, Takahashi M, Emi N, Kobayashi Y, Miyamura K, Fujita H, Sakura T, Iwanaga M, Usui N, Miyawaki S, Asou N, Ohnishi K, Miyazaki Y, Naoe T.
- Organizer
  Annual Meeting of the American Society of Hematology
- Place of Presentation
  San Francisco
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-24590688

1. TAKESHITA Akihiro (00242769)

# of Collaborated Projects: 12 results

# of Collaborated Products: 17 results
2. OHNO Ryuzo (70093002)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. NAKAMURA Satoki (20377740)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
4. ONO Takaaki (40402276)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
5. TAKESHITA Kaori (30397393)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
6. YOSHIDA Hitoshi (30303548)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. FUJIE Michio (90397373)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
8. MAEKAWA Masato (20190291)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
9. TOBITA Tadasu

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. NAMBA Hiroki (60198405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TOKUYAMA Tsutomu (90313957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YOKOTA Naoki (00273186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SHIBATA Kiyoshi (80397372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. NAOE Tomoki (50217634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAITO Kensuke (40334990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
16. SHIGENO Kazuyuki (50402251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SHOU Dong

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. CHEN Sai-juan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. CHEN Zhu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. WANG Zen-yi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. YANAGI Mitsuaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 大野龍三

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. CHUO Dong

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 新庄香

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. YAMAUCHI Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 黒川峰夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohnishi Kazunori 大西 一功

OHNISHI Kazunori 大西 一功

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The metabolome analysis of leukemic stem cellPrincipal Investigator

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Research for eradication of CML stem/progenitor cells which resisted Abl kinase inhibitorsPrincipal Investigator

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白血病における分子標的療法の至適臨床応用と併用による効果増強に関する研究Principal Investigator

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Retrovirus-mediated gene transfer of hematopoietic stimulating factor receptor cDNA into MDS cells and gene therapyPrincipal Investigator

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Ohnishi Kazunori 大西一功

OHNISHI Kazunori 大西一功

[Book] 癌と化学療法慢性骨髄性白血病に対するイマチニブ治療-10年を振り返り-2011

[Book] 癌と化学療法高齢者のがん薬物療法-血液-2011