KAWAMURA Kiyoko 川村希代子

Researcher Number	80260248
Other IDs
Affiliation (based on the past Project Information) *help	2011: 千葉県がんセンター(研究所), がん治療開発グループ, 上席研究員 2009 – 2010: Chiba Cancer Center (Research Institute), がん治療開発グループ, 主席研究員 2003 – 2008: 千葉県がんセンター(研究所), 病理研究部, 主席研究員 2002: Chiba Cancer Center Research Institute Division of Pathology Research Fellow, 病理研究部, 主席研究員 2001: 千葉県がんセンター, 病理研究部, 上席研究員 1999 – 2000: 千葉県がんセンター, 研究局・病理研究部, 主任研究員
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator HSV-TK / Tumor promoter / 腫瘍プロモーター / 遺伝子治療 / CD46 / アデノウイルス / 膵がん / 転写調節 / E1 / NF-1 … More / CAR / E1A / 腫瘍融解性ウイルス / Midkine / Survivin / c-erbB-2 / ミッドカイン / サバイビン / Transcriptional regulation / Gene therapy / IL-18 / IL-15 / IL-12 / 抗がん剤 / がん治療 / Pancreatic cancer / Adenovirus / 細胞受容体 / E3ファイバー領域 / シャトルベクター / ウイルス増殖 / CD45 / SCID mouse / Oncolytic virus / Transcription regulatory region / Gene Therapy / SCIDマウス / 転写調節領域 / Reporter assay / c-erb-B-2 / レポーターアッセイ / Suicide gene / Cyotokine / レトロウイルス / 転写制御 / 自殺遺伝子 / サイトカイン遺伝子 / Geldanamycin / ペメトレキセド / 塩酸ゲムシタビン / 細胞周期 / G2/M期 / アデノイルス / p53 / cytopathic effect / オートファジー / アポトーシス / 遺伝子医薬 / 細胞死 / 膵臓癌 / EIA遺伝子 / MDA-7 / インターロイキン24 / ファイバー・ノブ領域 / MDM-7 / E1A遺伝子 / 細胞傷害活性 / ウイルス / 膵臓がん Less

Anti-tumor effects for solid tumors in digestive tracts were produced by a chimeric type of oncolytic adenoviruses and the carrier cellsPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Kiyoko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba Cancer Center (Research Institute)
Therapeutic strategies with chimeric oncolytic adenoviruses and a cell-mediated delivery system for gastrointestinal solid tumorsPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Kiyoko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba Cancer Center (Research Institute)
Gene therapy for gastrointestinal tumors with adenovirus in which the fiber-knob region was replacedPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Kiyoko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba Cancer Center Research Institute
Gene therapy for intractable gastrointestinal tumors with tumor promoter-mediated oncolyitc adenovirusesPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Kiyoko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba Cancer Center Research Institute
Suicide gene therapy for intractable gastrointestinal cancer with tumor specific promotersPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Kiyoko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba Cancer Center Research Institute
Therapeutic effects of cytokine gene therapy and suicide gene therapy for gastrointestinal tumorsPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Kiyoko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba Cancer Center Research Institute

All 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed2012
- Author(s)
  Li, Q., Kawamura, K., Okamoto, S., Yamanaka, M., Yang, S., Yamauchi, S., Fukamachi, T., Kobayashi, H., Tada, Y., Takiguchi, Y., Tatsumi, K., Shimada, H., Hiroshima, K. and Tagawa, M.
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 19 Issue: 3 Pages: 218-228
- DOI
  10.1038/cgt.2011.86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590879, KAKENHI-PROJECT-22590850, KAKENHI-PROJECT-22591416, KAKENHI-PROJECT-23591136, KAKENHI-PROJECT-23591951, KAKENHI-PROJECT-24591185
[Journal Article] Adenoviruses-mediated transduction of human esophageal carcinoma cells with the interferon-lambda genes produced anti-tumor effects2011
- Author(s)
  Li, Q., Kawamura, K., Okamoto, S., Fujie, H., Numasaki, M., Namba, M., Nagata, M., Shimada, H., Kobayashi, H. and Tagawa, M.
- Journal Title
  
  Br. J. Cancer
  
  Volume: 105 Issue: 9 Pages: 1302-1312
- DOI
  10.1038/bjc.2011.379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590879, KAKENHI-PROJECT-22590869, KAKENHI-PROJECT-23591951
[Journal Article] A possible anti-cancer agent, type III interferon, activates cell death pathways and produces anti-tumor effects2011
- Author(s)
  Tagawa, M., Kawamura, K., Li, Q., Tada, Y., Hiroshima, K. and Shimada, H.
- Journal Title
  
  Clin. Dev. Immunol
  
  Volume: 2011 Pages: 1-6
- DOI
  10.1155/2011/479013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590879, KAKENHI-PROJECT-23591951
[Journal Article] Combinatory cytotoxic effects produced by E1B-55kDa-deleted adenoviruses and chemotherapeutic agents are dependent on the agents in esophageal carcinoma2010
- Author(s)
  Ma, G., Kawamura, K., Li, Q., Okamoto, S., Suzuki, N., Kobayashi, H., Liang, M., Tada, Y., Tatsumi, K., Hiroshima, K., Shimada, H. and Tagawa, M.
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 17 Issue: 11 Pages: 803-813
- DOI
  10.1038/cgt.2010.37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590879
[Journal Article] Cytotoxicity of adenoviruses expressing the wild-type p53 gene to esophageal carcinoma cells is linked with the CAR expression level and indirectly with the endogenous p53 status2009
- Author(s)
  Ma, G., Kawamura, K., Li, Q., Suzuki, N., Liang, M., Namba, M., Shimada, H. and Tagawa, M.
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 16 Issue: 11 Pages: 832-840
- DOI
  10.1038/cgt.2009.21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590879
[Journal Article] Cancer therapy with local oncolysis and topical cytokine secretion2008
- Author(s)
  Tagawa, M., Kawamura, K., Ueyama, T., Nakamura, M., Tada, Y., Ma, G., Li, Q., Suzuki, N., Shimada, H., Kuriyama, T. and Ochiai, T
- Journal Title
  
  Front. Biosci 13
  
  Pages: 2578-2587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590798
[Journal Article] The effects of FasL on inflammation and tumor survival are dependent on its2007
- Author(s)
  Wada A., Tada Y, Kawamura K., Takiguchi Y, Tatsumi K., Kuriyama T., Takenouchi T., O-Wang J., Tagawa M.
- Journal Title
  
  Cancer Gene Ther.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Adenovirus type 5 substituted with type 11 or type 35 fiber structure increases its infectivity to huma cells and enable dualgene transfer in CD46-dependent and -independent manners2007
- Author(s)
  Yu, L., Shimozato, O., Li, Q., Kawamura, K., Ma, G., Namba, M., Ogawa, T., Kaiho, I. And Tagawa, M
- Journal Title
  
  Antican
- Data Source
  KAKENHI-PROJECT-19590798
[Journal Article] Transcriptional regulatory regions of the survivin gene activate an exogenous suicide gene human tumors and enhance the sensitivity to a prodrug.2007
- Author(s)
  Kawamura, K
- Journal Title
  
  Anticancer Res. 27
  
  Pages: 89-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590798
[Journal Article] Transcriptional regulatory regions of the survivin gene activate an exogenous suicide gene human tumors and enhance the sensitivity to a prodrug.2007
- Author(s)
  Kawamura, K
- Journal Title
  
  Anticancer Res. 27
  
  Pages: 89-94
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Transcriptional regulatory regions of the survivin gene activate an exogenous suicide gene in human tumors and enhance the sensitivity to a prodrug2007
- Author(s)
  Kawamura, K., Yu, L., Tomizawa, M., Shimozato, O., Ma, G., Li, Q., Sato, A., Yang, Y., Suzuki, T., Abdel-Azizi, N. M., Tagawa, M
- Journal Title
  
  Anticancer Res 27
  
  Pages: 89-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590798
[Journal Article] Transcriptional regulatory regions of the survivin gene activate an exogenous suicide gene human tumors and enhance the sensitivity to a prodrug.2007
- Author(s)
  Kawamura K., Yu L., Tomizawa M., Shimozato 0., Ma G., Li Q., Sato A., Yang Y., Suzuki T., Abdel-Azizi N.M., Tagawa M.
- Journal Title
  
  Anticancer Res.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Transcriptional regulatory regions of the survivin gene activate an exogenous suicide gene human tumors and enhance the sensitivity to a prodrug2007
- Author(s)
  Kawamura, K
- Journal Title
  
  anticancer Res. 27
  
  Pages: 89-94
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Role of DNA polymerase θ in tolerance of endogenous and exogenous DNA damage in mouse B cells.2006
- Author(s)
  Ukai A., Maruyama T., Mochizuki S., Ouchida R., Masuda K., Kawamura K., Tagawa M., Kinoshita K., Sakamoto A., Tokuhisa T., O-Wang J.
- Journal Title
  
  Genes to Cells
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Role of DNA polymerase θ in tolerance of endogenous and exogenous DNA damage in mouse B cells.2006
- Author(s)
  Ukai A, Kawamura K et al.
- Journal Title
  
  Gene to Cells 11
  
  Pages: 111-121
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis.2006
- Author(s)
  Kawamura, K
- Journal Title
  
  anticancer Res. 26
  
  Pages: 4647-4652
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis.2006
- Author(s)
  Kawamura, K
- Journal Title
  
  Anticancer Res. 26
  
  Pages: 4647-4652
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Virology-and immunology-based gene therapy for cancer.2006
- Author(s)
  Tagawa M., Kawamura K., Shimozato 0., Ma G., Li Q., Suzuki N., Shimada H., Ochiai T.
- Journal Title
  
  Cancer Immunol. Immunother.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis.2006
- Author(s)
  Kawamura K., Takiguchi N., Wada A., Takenobu H., Kimura H., Soda H., Nagata M., Asano T., Tagawa M
- Journal Title
  
  Anticancer Res.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] DNA polymerase θ contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.2005
- Author(s)
  Masuda K, Kawamura K et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA, 102
  
  Pages: 13986-13991
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Increased infectivity of adenovirus type 5 bearing type 11 or type 35 fibers to human esophageal and oral carcinoma cells.2005
- Author(s)
  Yu L, Kawamura K et al.
- Journal Title
  
  Oncol.Rep. 14
  
  Pages: 831-835
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals.2005
- Author(s)
  Chiyo M, Kawamura K et al.
- Journal Title
  
  Int.J.Cancer 115
  
  Pages: 437-442
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] The secretion form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumor effects.2005
- Author(s)
  Shimozato O, Kawamura K et al.
- Journal Title
  
  Immunology 117
  
  Pages: 22-28
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals.2005
- Author(s)
  Chiyo M., Shimozato 0., Yu L., Kawamura K., Iizasa T., Fujisawa T., Tagawa M.
- Journal Title
  
  Int. J. Cancer
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] DNA polymerase θ contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.2005
- Author(s)
  Masuda K., Ouchida R., Takeuchi A., Saito T., Koseki H., Kawamura K., Tagawa M., Tokuhisa T., Azuma T., O-Wang J.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] Increased infectivity of adenovirus type 5 bearing type 11 or type 35 fibers to human esophageal and oral carcinoma cells.2005
- Author(s)
  Yu L., Takenobu H., Shimozato 0., Kawamura K., Nimura Y., Seki N., Uzawa K., Tanzawa H., Shimada H., Ochiai T., Tagawa M.
- Journal Title
  
  Oncol. Rep.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590692
[Journal Article] DNA polymerase θ is preferentially expressed in lymphoid tissues and upregulated in human cancers.2004
- Author(s)
  Kawamura Kiyoko
- Journal Title
  
  Int.J.Cancer 109
  
  Pages: 9-16
- Data Source
  KAKENHI-PROJECT-15590706
[Journal Article] Elevated expression of DNA polymerase κ expression in human lung cancer is associated with p53 inactivation : Negative regulation of POLK promoter activity by p53.2004
- Author(s)
  Wang, Y.Q., Seimiya, M., Kawamura, K., Yu, L., Ogi, T., Takenaga, K., Shishikura, T., Nakagawara, A., Sakiyama, S., Tagawa, M., O-Wang, J.
- Journal Title
  
  Int.J.Oncol. 25
  
  Pages: 161-165
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590706
[Journal Article] DNA polymerase θ is preferentially expressed in lymphoid tissues and upregulated in human cancers.2004
- Author(s)
  Kiyoko Kawamura
- Journal Title
  
  Int.J.Cancer 109
  
  Pages: 9-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590706
[Journal Article] DNA polymerase θ is preferentially expressed in lymphoid tissues and upregulated in human cancers.2004
- Author(s)
  Kawamura, K., Bahar, R., Seimiya, M., Chiyo, M., Wada, A., Okada, S., Hatano, M., Tokuhisa, T., Kimura, H., Watanabe, S., Honda, I., Sakiyama, S., Tagawa, M., O-Wang, J.
- Journal Title
  
  Int.J.Cancer 109
  
  Pages: 9-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590706
[Journal Article] Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts.2003
- Author(s)
  Ugai, S., Shimozato, O., Kawamura, K., Wang, Y-Q., Yamaguchi, T., Saisho, H., Sakiyama, S, Tagawa, M.
- Journal Title
  
  Cancer Gene Ther. 10
  
  Pages: 187-192
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590706
[Journal Article] Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation : elevated expression in human B lymphomas.2003
- Author(s)
  Seimiya, M., O-Wang, J., Bahar, R., Kawamura, K., Wang, Y., Saisho, H., Tagawa, M.
- Journal Title
  
  Int.J.Oncol. 22
  
  Pages: 301-304
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590706
[Journal Article] Cytotoxicity of adenoviruses expressing the wild-type p53 gene to esophageal carcinoma cells is linked with the CAR expression level and indirectly with the endogenous
- Author(s)
  Ma, G., Kawamura, K., Li, Q., Suzuki, N., Liang, M., Namba, M., Shimada, H. and Tagawa, M
- Journal Title
  
  Cancer Gene Ther (in press)
  
  Pages: 53-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590798
[Presentation] 制限増殖型アデノウイルスは、膵がん細胞においてアポトーシス、オートファジー非依存的な細胞死を誘導する2011
- Author(s)
  山内駿、川村希代子, その他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590879
[Presentation] 制限増殖型アデノウイルスは、膵がん細胞においてアポトーシス、オートファジー非依存的な細胞死を誘導する2011
- Author(s)
  山内駿、川村希代子、岡本慎也、楊珊、江媛媛、深町利彦、小林弘、多田裕司、巽浩一郎、島田英昭、廣島健三、田川雅敏
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590879
[Presentation] 悪性中皮腫における細胞融解性アデノウイルス感受性の検討2010
- Author(s)
  川村希代子、岡本慎也、深町利彦、小林弘、楊珊、久保秀司、山中満佳子、多田裕司、巽浩一郎、島田英昭、廣島健三、田川雅敏
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪市
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21590879
[Presentation] Cytotoxicity of Ad bearing the wt p53 to esophageal cancer is linked with the endogenous p53 status and CAR expression2009
- Author(s)
  馬光宇、川村希代子、李全海、鈴木健夫、佐藤彩子、張正茂、鈴木信夫、島田英昭、落合武徳
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2009-10-04
- Data Source
  KAKENHI-PROJECT-19590798
[Presentation] 制限増殖型アデノウイルスに対する腫瘍細胞の感受性を決定する因子の検討2009
- Author(s)
  川村希代子、李全海、武井優輝、山口直人、藤森浩中、多田裕司、山中満佳子、滝口裕一、巽浩一郎、廣島健三、島田英昭、田川雅敏
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590879
[Presentation] Replication-competent adenoviruses-medated tumor cell death is influenced by host-derived factors2008
- Author(s)
  Kawamura, K., Ma, G., Li, Q., Ueyama, T., Takei, Y., Tada, Y., Takiguchi, Y., Tatsumi, T., Suzuki, N., Yamaguchi, N., Hiroshima, K., Shimada
- Organizer
  International Society for Cell and Gene Therapy of Cancer 2008
- Place of Presentation
  Shijarzhuang, China
- Year and Date
  2008-09-21
- Data Source
  KAKENHI-PROJECT-19590798
[Presentation] Replication-competent adenoviruses-mediated tumor cell death is influenced by host-derived factors2008
- Author(s)
  川村希代子
- Organizer
  International Society for Cell and Gene Therapy of Cancer 2008
- Place of Presentation
  石家庄市、中国
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19590798
[Presentation] アデノウイルスによる腫瘍細胞死に対して影響を与える細胞因子の検討2008
- Author(s)
  川村希代子、馬光宇、李全海、植山太郎、廣島健三、島田英昭、多田裕司、滝口裕一、巽浩一郎,栗山喬之、田川雅敏
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19590798

1. TAGAWA Masatoshi (20171572)

# of Collaborated Projects: 6 results

# of Collaborated Products: 25 results
2. SAISHO Hiromitsu (10092058)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. YAMAGUCHI Taketo (00241969)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results

KAWAMURA Kiyoko 川村 希代子

Research Projects

Research Products

Co-Researchers

Anti-tumor effects for solid tumors in digestive tracts were produced by a chimeric type of oncolytic adenoviruses and the carrier cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic strategies with chimeric oncolytic adenoviruses and a cell-mediated delivery system for gastrointestinal solid tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene therapy for gastrointestinal tumors with adenovirus in which the fiber-knob region was replacedPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene therapy for intractable gastrointestinal tumors with tumor promoter-mediated oncolyitc adenovirusesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suicide gene therapy for intractable gastrointestinal cancer with tumor specific promotersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic effects of cytokine gene therapy and suicide gene therapy for gastrointestinal tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adenoviruses-mediated transduction of human esophageal carcinoma cells with the interferon-lambda genes produced anti-tumor effects2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A possible anti-cancer agent, type III interferon, activates cell death pathways and produces anti-tumor effects2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combinatory cytotoxic effects produced by E1B-55kDa-deleted adenoviruses and chemotherapeutic agents are dependent on the agents in esophageal carcinoma2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytotoxicity of adenoviruses expressing the wild-type p53 gene to esophageal carcinoma cells is linked with the CAR expression level and indirectly with the endogenous p53 status2009

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cancer therapy with local oncolysis and topical cytokine secretion2008

Author(s)

Journal Title

Data Source

[Journal Article] The effects of FasL on inflammation and tumor survival are dependent on its2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Adenovirus type 5 substituted with type 11 or type 35 fiber structure increases its infectivity to huma cells and enable dualgene transfer in CD46-dependent and -independent manners2007

Author(s)

Journal Title

Data Source

[Journal Article] Transcriptional regulatory regions of the survivin gene activate an exogenous suicide gene human tumors and enhance the sensitivity to a prodrug.2007

Author(s)

KAWAMURA Kiyoko 川村希代子