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Doi Shozaburo  土井 庄三郎

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DOI Shouzaburoh  土井 庄三郎

DOI Shouzaburou  土井 庄三郎

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Researcher Number 80262195
Other IDs
Affiliation (Current) 2025: 独立行政法人国立病院機構災害医療センター(臨床研究部), 臨床研究部, 院長
2025: 東京科学大学, その他の部局等, 非常勤講師
Affiliation (based on the past Project Information) *help 2019: 東京医科歯科大学, 医学部附属病院, 非常勤講師
2019: 東京医科歯科大学, 小児科, 非常勤講師
2016 – 2018: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授
2016: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 … More
2008: Tokyo Medical and Dental University, 医学部・附属病院, 講師
2007 – 2008: Tokyo Medical and Dental University, 医学部附属病院, 講師
2004: University Hospital, Faculty of Medicine, Department of Pediatrics, Lecturer, 医学部附属病院, 講師
2004: University Hospital, Faculty of Medicine, Assistant Professor, 医学部・附属病院, 講師
2002 – 2004: 東京医科歯科大学, 医学部附属病院, 講師 Less
Review Section/Research Field
Principal Investigator
Pediatrics
Except Principal Investigator
Pediatrics / Embryonic/Neonatal medicine / 応用薬理学・医療系薬学
Keywords
Principal Investigator
arginase / 肺高血圧 / 右心不全 / 右室肥大 / モノクロタリン / 肺小動脈リモデリング / βarrestin / アポトーシス / 平滑筋細胞増殖 / IL-6 … More / NF-kB / βアレスチン / 肺動脈リモデリング / 肺高血圧症 / インターロイキン6 / 線維芽細胞増殖因子2 / 肺動脈平滑筋細胞増殖 / デクスメデトミジン / 肺動脈性肺高血圧症 / dimenthylarginine dimethylaminohydrolase (DDAH) / L-arginine / ornithine decarboxylase (ODC) / endogenos NOS inhibitors / nitric oxide synthase (NOS) / pulmonary vascular remodeling / pulmonary hypertension (PH) / DDAH / ODC / 内因性NO合成酵素阻害物質 / eNOS / ジメチルアルギニン・ジメチルアミノハイドロラーゼ(DDAH) / L-アルギニン / オルニチン・デカルボキシラーゼ(ODC) / 内因性NO合成酵素阻害物質(NOS inhibitors) / アルギナーゼ / 一酸化窒素合成酵素(NOS) / 肺血管リモデリング / 肺高血圧(PH) / 新生内膜増殖性病変 / 肺動脈性高血圧 / PAHモデルラット / 肺小動脈理モデリング / 血管内皮細胞増殖因子受容体阻害剤 / 精巣・卵巣摘出 / 性ステロイド / 性差 / 血管内皮細胞増殖因子受容体阻害剤SU-5416 / 肺細小動脈新生内膜増殖性変化 / 肺動脈性肺高血圧 … More
Except Principal Investigator
Ornithine aminotransferase / Ornithine decarboxylase / Aldose reductase / Polyamines / Endogenous NOS inhibitors / Enhanced arginase activity / Hyperglycemia / 小児気管支喘息 / RSウイルス感染症 / 小児科学 / 新生児学 / 炎症 / 新生児慢性肺疾患 / 生理学 / 免疫学 / 呼吸器病学 / 集中治療医学 / 新生児医学 / DPP-4阻害薬 / GLP-1受容体作動薬 / 肺高血圧症の改善 / prolonged QT / monocrotaline induced pulmonary artery hypertension model rats / in vivo electrophysiological studies / 心臓電気生理学的検査 / 病理的心筋リモデリング / 電気的心筋リモデリング / 肺高血圧ラット / QT延長 / モノクロタリン誘発肺高血圧ラット / 臨床心臓電気生理学的検査 / Endogenous arginase inhibitor / Acceleration of intimal hyperplasia / Vascular remodeling / Proline / Nitric oxide / Nitric oxide synthase / L-Arginine / Polyamine / OAT / ODC / Ornithine / DDAH / Arginase / NO synthase / omithine decarboxvlase (ODC) / putrescine / N^G-hydroxy-L-arginine / arginase活性亢進 / 内膜肥厚増悪 / 高血糖 / Accelerated intimal hyperplasia Less
  • Research Projects

    (7 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (14 People)
  •  New therapeutic tool of Dexmedetomidine for pulmonary arterial hypertensionPrincipal Investigator

    • Principal Investigator
      Doi Shozaburo
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Medical and Dental University
  •  肺高血圧症の病態に、インスリン分泌促進ホルモン、およびその分解酵素は関与するか?

    • Principal Investigator
      細川 奨
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Medical and Dental University
  •  The role and kinetics of inflammation in neonatal chronic lung disease

    • Principal Investigator
      Wakabayashi Kenji
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Effects of sex steroids on pulmonary hypertension-From the standpoint of sex difference in idiopathic pulmonary arterial hypertension-Principal Investigator

    • Principal Investigator
      DOI Shouzaburou
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Medical and Dental University
  •  Research for the clarification of the modulating mechanisms of pulmonary vascular remodeling associated with pulmonary hypertensionPrincipal Investigator

    • Principal Investigator
      DOI Shozaburo
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Medical and Dental University
  •  Interaction Between Electrical and Pathological Myocardial Remodeling Induced by Right and Left Ventricular Pressure Overload

    • Principal Investigator
      WAKIMOTO Hiroko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Medical and Dental University
  •  Acceleration of intinul hyperplasia by the enhanced arginase activity due to hyperglycemia

    • Principal Investigator
      AZUMA Hiroshi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical and Dental University

All 2019 2015 2005

All Journal Article Presentation

  • [Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the Rat.2005

    • Author(s)
      Sasaki A, Doi S, Wakimoto H, Takahashi R, Azuma H.
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine 171(7)

    • Data Source
      KAKENHI-PROJECT-15591090
  • [Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the rat.2005

    • Author(s)
      Sasaki A, Doi S, Wakimoto H, Takahashi R, Azuma H.
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine Vol 2

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591090
  • [Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the rat2005

    • Author(s)
      Sasaki A, Doi S, Wakimoto H, Takahashi R, Azuma H
    • Journal Title

      American Thoracic Society 2005 San Diego International Conference Abstracts Issue Volume 2

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591090
  • [Presentation] 肺高血圧症進展過程におけるデクスメデトミジンの効果2019

    • Author(s)
      山口洋平, 細川奨, 土井庄三郎他4名
    • Organizer
      第26回日本小児肺循環研究会
    • Data Source
      KAKENHI-PROJECT-16K10061
  • [Presentation] Dexmedetomidine Ameliorates Monocrotaline Induced Pulmonary Arterial Hypertension in Rats2015

    • Author(s)
      Kajikawa Y, Hosokawa S, Wakabayashi K, Maejima Y, Isobe M, Doi S
    • Organizer
      American Heart Association Scientific Sessions 2015
    • Place of Presentation
      Orange County Convention Center, Orland USA
    • Year and Date
      2015-11-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860843
  • [Presentation] Dexmedetomidine ameliorates monocrotaline induced pulmonary arterial hypertension in rats2015

    • Author(s)
      梶川 優介、細川 奨、若林 健二、 前嶋 康浩、磯部 光章、土井 庄三郎
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-04-27
    • Data Source
      KAKENHI-PROJECT-26860843
  • [Presentation] 肺高血圧症の進展におけるデクスメデトミジンの役割2015

    • Author(s)
      梶川優介 、若林健二 、細川奨 、土井庄三郎、前嶋康浩、磯部光章
    • Organizer
      第21回日本小児肺循環研究会
    • Place of Presentation
      笹川記念会館
    • Year and Date
      2015-01-31
    • Data Source
      KAKENHI-PROJECT-26860843
  • [Presentation] The synergistic effects of Incretin-related drugs for the treatment of pulmonary arterial hypertension.2015

    • Author(s)
      Hosokawa S, Haraguchi G, Maejima Y, Doi S, Isobe M.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-04-25
    • Data Source
      KAKENHI-PROJECT-15K09684
  • [Presentation] Dexmedetomidine ameliorates monocrotaline induced pulmonary arterial hypertension in rats2015

    • Author(s)
      梶川優介, 若林健二, 細川奨, 前嶋康浩, 磯部光章, 土井庄三郎
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪府大阪市
    • Year and Date
      2015-04-24
    • Data Source
      KAKENHI-PROJECT-26860843
  • 1.  AZUMA Hiroshi (20134736)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 2.  WAKIMOTO Hiroko (60345296)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  OBAYASHI Satoshi (10262180)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  FURUKAWA Tetsushi (80251552)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  Wakabayashi Kenji (20723795)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 6.  TAKI Atsuko (20614481)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  UCHIDA Tokujiro (40262183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  今村 公俊 (40422472)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  佐々木 章人 (20328454)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  増田 均 (60323680)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  細川 奨 (00737025)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  前嶋 康浩 (40401393)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  磯部 光章 (80176263)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  TAKATA Masao
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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