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hara takahiko  原 孝彦

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HARA Takahiko  原 孝彦

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Researcher Number 80280949
Other IDs
External Links
Affiliation (Current) 2025: 公益財団法人東京都医学総合研究所, 基盤技術支援センター, 参事研究員
Affiliation (based on the past Project Information) *help 2024: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 分野長
2020 – 2022: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 分野長
2017 – 2019: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 分野長
2016 – 2017: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 参事研究員
2013 – 2014: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, プロジェクトリーダー(参事研究員) … More
2012: 公共財団法人東京都医学総合研究所, 生体分子先端研究分野, 副参事研究員
2012: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 副参事研究員
2011: (財)東京都医学総合研究所, 生体分子先端研究分野, 副参事研究員
2011: 財団法人東京都医学総合研究所, 生体分子先端研究分野, 幹細胞プロジェクトリーダー
2008: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 副参事研究員
2007 – 2008: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 副参事研究員
2004 – 2006: Tokyo Metropolitan Organization for Medical Research, The Tokyo Metropolitan Institute of Medical Science, laboratory head, 東京都臨床医学総合研究所, 副参事研究員
2003 – 2004: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 副参事研究員
2003: The Tokyo Metropolitan Institute of Medical Science, Senior Researcher, 東京都臨床医学総合研究所, 副参事研究員
2001 – 2003: 東京都医学研究機構, 東京都臨床医学総合研究所, 副参事研究員
2001 – 2002: 財団法人 東京都医学研究機構, 東京都臨床医学総合研究所, 副参事研究員
2001: 財団法人 東京都医学研究機構, 東京都臨床医学総合研究所, 研究員
2001: Tokyo Metropolitan Organization For Medical Research, The Tokyo Metropolitan Institute of Medical Science, Department of Tumor Biochemistry, Head, 東京都臨床医学総合研究所, 副参事研究員
2000 – 2001: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員
1999: 財団法人 東京都医学研究機構, 東京都臨床医学総合研究所, 研究員
1997 – 1999: Institute of Molecular and Cellular Biosciences, The University of Tokyo, ASSOCI, 分子細胞生物学研究所, 助教授
1996: 東京大学, 分子細胞生物学研究所, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Hematology / Basic Section 54010:Hematology and medical oncology-related / Basic Section 53050:Dermatology-related / Medical genome science / Hematology / Cell biology / General medical chemistry / Endocrinology / Obstetrics and gynecology … More / Urology / Plastic surgery / Urology / Functional biochemistry … More
Except Principal Investigator
広領域 / Drug development chemistry / Obstetrics and gynecology / Experimental pathology / Immunology Less
Keywords
Principal Investigator
造血幹細胞 / CXCL14 / セルトリ細胞 / 精巣 / 精原細胞 / 分化転換 / 造血発生 / AGM領域 / LIF / サイトカイン … More / オンコスタチンM / AGM region / c-myb / PCLP1 / ケモカイン / マクロファージ / ES細胞 / 遺伝子 / 幹細胞 / 骨髄幹細胞 / 血管内皮細胞 / 発生可塑性 / ヘマンジオブラスト / サイトカイン受容体 / 始原生殖細胞 / FADS2 / 低分子化合物 / 抗がん剤 / 白血病 / T-ALL / 自然免疫 / CpG DNA / TLR9 / 転写因子 / iPS細胞 / Gene / Hematopoietic development / Blood cells / Bone marrow stem cells / Transdifferentiation / Hematopoietic stem cells / 発生 / 血液細胞 / stem cell plasticity / endothelial cells / hematopoietic stem cells / AML1 / hemangioblast / Runix-1 / Runx-1 / signal transduction / cytokine receptor / cytokine / oncostatinM / IL-6 / シグナル伝達 / タンパク質品質管理 / アンチエイジング / ユビキチン化 / 老化 / ハダカデバネズミ / プロテアソーム / 摂食行動 / 粘膜組織 / CXCR4 / 内分泌学 / 急性骨髄性白血病 / Lhx2 / CMG-1 / CXCL12 / ES細胞分化 / ニッチ / 骨髄ニッチ / 卵巣 / 子宮 / リポカリン2 / サイクリンD2 / 精子 / アポトーシス / 損傷治癒 / 筋再生 / BRAK / FRP2 / マイクロアレイ / c-Kit / 遺伝子発現 / c-KIt / 24p3 / 転写制御 / 血管新生 / 固形癌 / 骨髄 / 神経ガイダンス … More
Except Principal Investigator
RAS / STAT / 細胞死 / 細胞増殖 / サイトカイン受容体 / シグナル伝達 / アポトーシス / サイトカイン / signal transduction / 細胞分化 / 造血 / 造血因子 / mac25 / Wv / W / JSD / RDA / 生殖細胞 / apoptosis / hematopoiesis / cytokine receptors / cytokine / JAK / 発生 / 血管内皮 / 分化 / 遺伝子発現 / キナーゼ / Ras / 配列特異的反応 / タンパク質ヒドラジド / タンパク質チオエステル / プロテアーゼ / タンパク質半合成 / タンパク性医薬品 / カルボキシペプチダーゼ / 配列選択的反応 / タンパク質化学合成 / インテイン / チオエステル / タンパク質修飾 / タンパク性医薬 / Endometrium / Implantation / 子宮内膜 / 着床 / FACS / in situ hybridization / Lipocalin / spermatogonia / cDNA microarry / ホモロジー検索 / ノーザンブロット / 遺伝子変化 / サブトラクション / マウス精巣 / 癌 / cDNARDA / 癌抑制遺伝子 / リポカリン / cDNAマイクロアレイ / 精原細胞 / development / endothelial cells / germ cells / 白血病 / 始原生殖細胞 / セルトリ細胞 / オンコスタチンM / 血管内皮細胞 / cell death / cell differentiation / cell proliferation / hematopoietic growth factors / cytokines / 転写因子 / JAKキナーゼ / レトロウイルス / differentiation / 増殖 / 造血細胞 / 幹細胞 / 誘導遺伝子 / サイトカン受容体 / サイトカン / Caspase Less
  • Research Projects

    (26 results)
  • Research Products

    (164 results)
  • Co-Researchers

    (33 People)
  •  Action mechanism of the chemical compounds which specifically kills human T-ALL cellsPrincipal Investigator

    • Principal Investigator
      原 孝彦
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Mechanism of CXCL14-mediated skin immunosurveillancePrincipal Investigator

    • Principal Investigator
      HARA Takahiko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Development of methods for modification of proteins with its application to protein drugs

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokushima
  •  Investigation of developmental regulators for human hematopoietic stem cells and downstream road-blocker(s) of Lhx2Principal Investigator

    • Principal Investigator
      HARA Takahiko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical genome science
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Molecular analysis of protein quality control system of the extraordinarily long-lived rodentPrincipal Investigator

    • Principal Investigator
      HARA Takahiko
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Characterization and exploration of bone marrow niche regulators for hematopoietic stem cellsPrincipal Investigator

    • Principal Investigator
      HARA Takahiko
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Role of CXCL14 as a sensor for behavior-stimulating substancePrincipal Investigator

    • Principal Investigator
      HARA Takahiko
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Endocrinology
    • Research Institution
      公共財団法人東京都医学総合研究所
      Tokyo Metropolitan Organization for Medical Research
  •  子宮・卵巣に高発現するケモカインCXCL14の生理的役割の解析Principal Investigator

    • Principal Investigator
      原 孝彦
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Identification and functional analyses of proteins which are involved in the sterility and sperm production in testisPrincipal Investigator

    • Principal Investigator
      HARA Takahiko
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Urology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  損傷臓器の治癒再生を促進する分泌性タンパク質の解析Principal Investigator

    • Principal Investigator
      原 孝彦
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Plastic surgery
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  組織幹細胞の系統決定を支配する遺伝子プログラムPrincipal Investigator

    • Principal Investigator
      原 孝彦
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Identification of genes which are involved in the development and transdifferentiation of hematopoietic stem cellsPrincipal Investigator

    • Principal Investigator
      HARA Takahiko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH
  •  精巣の分化成熟を支配する精原細胞因子の解明Principal Investigator

    • Principal Investigator
      原 孝彦
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Urology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  造血幹細胞の発生万能性の検証と分子基盤Principal Investigator

    • Principal Investigator
      原 孝彦
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  腫瘍特異的な血管新生因子の探索Principal Investigator

    • Principal Investigator
      原 孝彦
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Physiological role of implantation-associated factor Mac25 and the molecular mechanisms of implantation

    • Principal Investigator
      KOGO Hiroshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Isolation of genes involved in carcinogenesis of spermat ogonial stem cells

    • Principal Investigator
      TANAKA Kiyoko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo Metropolitan Organization For Medical Research The Tokyo Metropolitan Institute of Medical Science
  •  Attempt to induce hematoopoietic stem cells from hemangioblastsPrincipal Investigator

    • Principal Investigator
      HARA Takahiko
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Metropolitan Organization For Medical Research, The Tokyo Metropolitan Institute of Medical Science
  •  ニューロン伸展と血球発生の共通細胞機能Principal Investigator

    • Principal Investigator
      原 孝彦
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo
  •  生殖始原細胞の増殖分化に作用する新規サイトカインの探索Principal Investigator

    • Principal Investigator
      原 孝彦
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  サイトカインによる細胞の増殖分化と細胞死のシグナル伝達

    • Principal Investigator
      MIYAJIMA Atsushi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Immunology
    • Research Institution
      Institute of Molecular and Cellular Biosciences, The University of Tokyo
  •  生殖始原細胞の増殖分化に作用する新規サイトカインの探索Principal Investigator

    • Principal Investigator
      原 孝彦
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Molecular Mechanism and physiological role of growth suppression by oncostatinMPrincipal Investigator

    • Principal Investigator
      HARA Takahiko
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      The University of Tokyo
  •  サイトカインによる造血細胞の増殖制御機構

    • Principal Investigator
      MIYAJIMA Atsushi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  サイトカインによるシグナル伝達機構の解析

    • Principal Investigator
      MIYAJIMA Atsushi
    • Project Period (FY)
      1995 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      広領域
    • Research Institution
      Institute of Molecular and Cellular Biosciencesa, The University of Tokyo
  •  Control of cytokine function by modified signaling molecules

    • Principal Investigator
      MIYAJIMA Atsushi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      広領域
    • Research Institution
      Institute of Molecular and Cellular Biosciences, The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] 発生における細胞増殖制御-造血幹細胞分化と増殖制御2004

    • Author(s)
      原 孝彦
    • Publisher
      シュプリンガー・フェアラーク東京
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390308
  • [Journal Article] Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity2022

    • Author(s)
      Tsujihana Kojiro、Tanegashima Kosuke、Santo Yasuko、Yamada Hiroyuki、Akazawa Sota、Nakao Ryuta、Tominaga Keiko、Saito Risa、Nishito Yasumasa、Hata Ryu-Ichiro、Nakamura Tomonori、Murai Iori、Kono Yuka、Sugawa Maho、Tanioka Miki、Egawa Gyohei、Doi Masao、Isa Tadashi、Kabashima Kenji、Hara Takahiko、Okamura Hitoshi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 25 Pages: 25-25

    • DOI

      10.1073/pnas.2116027119

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07208, KAKENHI-PROJECT-22K18384, KAKENHI-PROJECT-20K20864, KAKENHI-ORGANIZER-20H05760, KAKENHI-ORGANIZER-20H05782, KAKENHI-PLANNED-20H05783, KAKENHI-PROJECT-22H04987, KAKENHI-PROJECT-20K08702, KAKENHI-PROJECT-20K21426, KAKENHI-PROJECT-18H04015, KAKENHI-PROJECT-20H05697, KAKENHI-PROJECT-22H04992, KAKENHI-PROJECT-22H00441
  • [Journal Article] Identification of functional domains of CXCL14 involved in high-affinity binding and intracellular transport of CpG DNA2021

    • Author(s)
      R. Iwase, N. Naruse, M. Nakagawa, R. Saito, A. Shigenaga, A. Otaka, T. Hara, and K. Tanegashima
    • Journal Title

      J. Immunol.

      Volume: 207 Issue: 2 Pages: 459-469

    • DOI

      10.4049/jimmunol.2100030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08702, KAKENHI-PROJECT-21K07208
  • [Journal Article] A Photo-Activatable Peptide Mimicking Functions of Apolipoprotein A-I2019

    • Author(s)
      Haruka Kawahara, Naoki Miyashita, Kohki Tachibana, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 6 Pages: 1019-1024

    • DOI

      10.1248/bpb.b19-00114

    • NAID

      130007657697

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-06-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16K08236
  • [Journal Article] Latrophilin2 is involved in neural crest cell migration and placode patterning in Xenopus laevis.2019

    • Author(s)
      Yokote N., Suzuki-Kosaka Y. M., Michiue T., Hara T., Tanegashima K.
    • Journal Title

      International Journal of Developmental Biology

      Volume: 63 Issue: 1-2 Pages: 29-35

    • DOI

      10.1387/ijdb.180184kt

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07313, KAKENHI-PROJECT-16H04728, KAKENHI-PROJECT-17KT0049, KAKENHI-PROJECT-18K06244, KAKENHI-PUBLICLY-18H04967, KAKENHI-PUBLICLY-19H04948
  • [Journal Article] Inhibitory action of an ERK1/2 inhibitor on primitive endoderm cell differentiation from mouse embryonic stem cells.2019

    • Author(s)
      H. Tabata, T. Hara, and K. Kitajima.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 512 Issue: 2 Pages: 399-404

    • DOI

      10.1016/j.bbrc.2019.03.081

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H04728, KAKENHI-PROJECT-17K09911
  • [Journal Article] Domain-specific biological functions of the transcription factor Gata2 on hematopoietic differentiation of mouse embryonic stem cells2018

    • Author(s)
      Kitajima Kenji、Kanokoda Mai、Nakajima Marino、Hara Takahiko
    • Journal Title

      Genes to Cells

      Volume: 23 Issue: 9 Pages: 753-766

    • DOI

      10.1111/gtc.12628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09911, KAKENHI-PROJECT-16H04728
  • [Journal Article] DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene.2018

    • Author(s)
      K. Tanaka, N. Ikeda, K. Miyashita, H. Nuriya, and T. Hara.
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 8 Pages: 2479-2489

    • DOI

      10.1111/cas.13661

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Journal Article] Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels2018

    • Author(s)
      Miyashita Kazuya、Kitajima Kenji、Goyama Susumu、Kitamura Toshio、Hara Takahiko
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Issue: 3 Pages: 2310-2316

    • DOI

      10.1016/j.bbrc.2017.12.135

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09911, KAKENHI-PROJECT-16H04728
  • [Journal Article] CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity2017

    • Author(s)
      Tanegashima Kosuke、Takahashi Rena、Nuriya Hideko、Iwase Rina、Naruse Naoto、Tsuji Kohei、Shigenaga Akira、Otaka Akira、Hara Takahiko
    • Journal Title

      EBioMedicine

      Volume: 24 Pages: 247-256

    • DOI

      10.1016/j.ebiom.2017.09.012

    • NAID

      120006941113

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16H04728, KAKENHI-PROJECT-17J03475
  • [Journal Article] Epigenetic regulation of the glucose transporter gene Slc2a1 by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice.2017

    • Author(s)
      Tanegashima, Y. Sato-Miyata, M. Funakoshi, Y. Nishito, T. Aigaki, and T. Hara.
    • Journal Title

      Genes to Cells

      Volume: 22 Issue: 1 Pages: 71-83

    • DOI

      10.1111/gtc.12456

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Journal Article] Stapled BIG3 helical peptide ERAP potentiates antitumour activity for breast cancer therapeutics.2017

    • Author(s)
      Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T
    • Journal Title

      Scientific Reports

      Volume: 印刷中 Issue: 1 Pages: 1821-1821

    • DOI

      10.1038/s41598-017-01951-6

    • NAID

      120006535017

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-17K19492, KAKENHI-PUBLICLY-16H01575, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16H05153
  • [Journal Article] Cysteine-Free Intramolecular Ligation of N-Sulfanylethylanilide Peptide Using 4-Mercaptobenzylphosphonic Acid: Synthesis of Cyclic Peptide Trichamide2017

    • Author(s)
      Otaka Akira、Aihara Keisuke、Inokuma Tsubasa、Jichu Takahisa、Lin Zhenjian、Fu Feixue、Yamaoka Kosuke、Shigenaga Akira、Hutchins David、Schmidt Eric
    • Journal Title

      Synlett

      Volume: 28 Issue: 15 Pages: 1944-1949

    • DOI

      10.1055/s-0036-1589055

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Journal Article] Transfer of a mouse artificial chromosome into spermatogonial stem cells genetates transchromosomic mice,2017

    • Author(s)
      Shinohara T, Kazuki K, Ogonuki N, Morimoto H, Matoba S, Hiramatsu K, Honma K, Suzuki T, Hara T, Ogura A, Oshimura M, Kanatsu-Shinohara M, Kazuki Y.
    • Journal Title

      Stem Cell Reports.

      Volume: 9(4) Issue: 4 Pages: 1180-1191

    • DOI

      10.1016/j.stemcr.2017.08.012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08136, KAKENHI-PUBLICLY-17H05639, KAKENHI-PLANNED-25112003, KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-16H04728, KAKENHI-PROJECT-16H06146, KAKENHI-PROJECT-15K14362, KAKENHI-PROJECT-15K15013
  • [Journal Article] Highly Efficient Transfer of Chromosomes to a Broad Range of Target Cells Using Chinese Hamster Ovary Cells Expressing Murine Leukemia Virus-Derived Envelope Proteins.2016

    • Author(s)
      Suzuki T, Kazuki Y, Oshimura M, Hara T.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 6 Pages: e0157187-e0157187

    • DOI

      10.1371/journal.pone.0157187

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25221308, KAKENHI-PROJECT-15H04285, KAKENHI-PROJECT-16H04728
  • [Journal Article] Facile Preparation of Peptides with C-Terminal <i>N</i>-Alkylamide <i>via</i> Radical-Initiated Dethiocarboxylation2016

    • Author(s)
      Shimizu, T.; Miyajima, R.; Naruse, N.; Yamaoka, K.; Aihara, K.; Shigenaga, A.*; Otaka, A.*
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 4 Pages: 375-378

    • DOI

      10.1248/cpb.c15-01025

    • NAID

      130005141024

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K14979
  • [Journal Article] One-pot/sequential native chemical ligation using photo-caged crypto-thioester2016

    • Author(s)
      Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka
    • Journal Title

      Organic Letters

      Volume: 18 Issue: 3 Pages: 596-599

    • DOI

      10.1021/acs.orglett.5b03661

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K07858
  • [Journal Article] Development of an intein-inspired amide cleavage chemical device2016

    • Author(s)
      Komiya, C.; Aihara, K.; Morishita, K.; Ding, H.; Inokuma, T.; Shigenaga, A.; Otaka, A.*
    • Journal Title

      J. Org. Chem.

      Volume: 81 Issue: 2 Pages: 699-707

    • DOI

      10.1021/acs.joc.5b02399

    • NAID

      120006493349

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-16H02611
  • [Journal Article] Efficient production of platelets from mouse embryonic stem cells by enforced expression of Gata2 in late hemogenic endothelial cells.2016

    • Author(s)
      M. Kawaguchi, K. Kitajima, M. Kanokoda, H. Suzuki, K. Miyashita, M. Nakajima, H. Nuriya, K. Kasahara, and T. Hara.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 474 Issue: 3 Pages: 462-468

    • DOI

      10.1016/j.bbrc.2016.04.140

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Journal Article] CXCL14 antagonizes the CXCL12-CXCR4 signaling axis2014

    • Author(s)
      T. Hara and K. Tanegashima
    • Journal Title

      BioMol. Concepts

      Volume: 5 Pages: 167-173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] CXCL14 antagonizes the CXCL12-CXCR4 signaling axis.2014

    • Author(s)
      T. Hara and K. Tanegashima
    • Journal Title

      BioMol. Concepts

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis2013

    • Author(s)
      K. Tanegashima, K. Suzuki, Y. Nakayama, K. Tsuji, A. Shigenaga, A. Otaka, and T. Hara
    • Journal Title

      FEBS Letters

      Volume: 587 Pages: 1731-1735

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic progenitor cells derived from mouse embryonic stem cells2013

    • Author(s)
      K. Kitajima, M. Kawaguchi, M. Iacovino, M. Kyba, and T. Hara
    • Journal Title

      Stem Cells

      Volume: 31 Pages: 2680-2689

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] Dimeric peptides of the C-terminal region of CXCL14 function as CXCL12 inhibitors2013

    • Author(s)
      K. Tanegashima, K. Tsuji, K. Suzuki, A. Shigenaga, A. Otaka, and T. Hara
    • Journal Title

      FEBS Letters

      Volume: 587 Pages: 3770-3775

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] Dimeric peptides of the C-terminal region of CXCL14 function as CXCL12 inhibitors2013

    • Author(s)
      K. Tanegashima, K. Tsuji, K. Su zuki, A. Shigenaga, A. Otaka, and T. Hara
    • Journal Title

      FEBS Letters

      Volume: 587 Issue: 23 Pages: 3770-3775

    • DOI

      10.1016/j.febslet.2013.10.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J08863, KAKENHI-PROJECT-23390256, KAKENHI-PROJECT-25860304
  • [Journal Article] Synthesis of antagonistic peptide for putative CXCL14 receptor protein and their identification2013

    • Author(s)
      K. Tsuji, K. Tanegashima, A. Shigenaga, K. Aihara, M. Denda, H. Ding, T. Hara, and A. Otaka
    • Journal Title

      Peptide Science

      Pages: 31-32

    • NAID

      10031161538

    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic progenitor cells derived from mouse embryonic stem cells.2013

    • Author(s)
      K. Kitajima, M. Kawaguchi, M. Iacovino, M. Kyba, and T. Hara
    • Journal Title

      Stem Cells

      Volume: 31 Issue: 12 Pages: 2680-2689

    • DOI

      10.1002/stem.1500

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390256, KAKENHI-PROJECT-24591415
  • [Journal Article] CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis2013

    • Author(s)
      K. Tanegashima, K. Suzukia, Y. Nakayama, K. Tsuji, A. Shigenaga, A. Otaka, and T. tiara
    • Journal Title

      FEBS Letters

      Volume: 587 Issue: 12 Pages: 1731-1735

    • DOI

      10.1016/j.febslet.2013.04.046

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J08863, KAKENHI-PROJECT-22791043, KAKENHI-PROJECT-23390256, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-23659481, KAKENHI-PROJECT-25860304, KAKENHI-PUBLICLY-23126528
  • [Journal Article] ES細胞・iPS細胞から機能的な血液細胞を作り出す方法2012

    • Author(s)
      原 孝彦, 北島健二
    • Journal Title

      実験医学

      Volume: 30(増刊号) Pages: 1671-1676

    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] Pleiotropic functions of the CXC-type chemokine CXCL14 in mammals.2012

    • Author(s)
      T. Hara and K. Tanegashima
    • Journal Title

      J. Biochem.

      Volume: 151 Issue: 5 Pages: 469-476

    • DOI

      10.1093/jb/mvs030

    • NAID

      10031166086

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390256, KAKENHI-PROJECT-23659481
  • [Journal Article] ES細胞・iPS細胞から機能的な血液細胞を作り出す方法2012

    • Author(s)
      原孝彦, 北島健二
    • Journal Title

      実験医学(増刊号)

      Volume: 30 Pages: 1671-1676

    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] CXCL142012

    • Author(s)
      種子島幸祐, 原 孝彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 57 Pages: 330-335

    • Data Source
      KAKENHI-PROJECT-23659481
  • [Journal Article] Pleiotropic functions of the CXC-type chemokine CXCL14 in mammals2012

    • Author(s)
      T. Hara and K. Tanegashima
    • Journal Title

      J. Biochem

      Volume: 151 Pages: 469-476

    • NAID

      10031166086

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] Directing migration of endothelial progenitor cells with applied DC electric fields2012

    • Author(s)
      Z.Zhao, L.Oin, B.Reid, J.Pu, T.Hara, M.Zhao
    • Journal Title

      Stem Cell Research

      Volume: 8 Issue: 1 Pages: 38-48

    • DOI

      10.1016/j.scr.2011.08.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx22011

    • Author(s)
      K.Kitajima, K.Minehata, K.Sakimura, T.Nakano, T.Hara
    • Journal Title

      Blood

      Volume: 117 Issue: 14 Pages: 3748-3758

    • DOI

      10.1182/blood-2010-07-298596

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] Application of N-C-or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation2011

    • Author(s)
      Tsuji, K.; Shigenaga, A.; Sumikawa, Y.; Tanegashima, K.; Sato, K.; Aihara, K.; Hara, T.; Otaka, A
    • Journal Title

      Bioorg. Med. Chem

      Volume: 19 Issue: 13 Pages: 4014-4020

    • DOI

      10.1016/j.bmc.2011.05.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-23659481
  • [Journal Article] iPS細胞から造血幹細胞への分化誘導2011

    • Author(s)
      北島健二、原孝彦
    • Journal Title

      医学のあゆみ(増刊号)

      Volume: 239 Pages: 1397-1401

    • Data Source
      KAKENHI-PROJECT-23390256
  • [Journal Article] DDX1 is required for testicular tumorigenesis, partially through the transcriptional activation of 12p stem cell genes2009

    • Author(s)
      K. Tanaka, S. Okamoto, Y. Ishikawa, H. Tamura, T. Hara
    • Journal Title

      Oncogene (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] CXCL14 and insulin action2009

    • Author(s)
      T. Hara, Y. Nakayama
    • Journal Title

      Vitamins and Hormones 80

      Pages: 107-123

    • Data Source
      KAKENHI-PROJECT-19659430
  • [Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells2009

    • Author(s)
      S. Ohata, M. Nawa, 8 authors, T. Hara, S. Terai, I. Sakaida, T. Katada, H. Nishina
    • Journal Title

      Biochem. Biophys. Res. Commun. 379

      Pages: 817-823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] DDX1 is required for testicular tumorigenesis, partially through the transcriptional activation of 12p stem cell genes.2009

    • Author(s)
      K. Tanaka, S. Okamoto, Y. Ishikawa, H. Tamura, and T. Hara.
    • Journal Title

      Oncogene, advance online publication April 27

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells.2009

    • Author(s)
      S. Ohata, M. Nawa, T. Kasama, T. Yamasaki, K. Sawanoboria, S. Hata, T. Nakamura, Y. Asaoka, T. Watanabe, H. Okamoto, T. Hara, S. Terai, I. Sakaida, T. Katada, and H. Nishina.
    • Journal Title

      Biochem. Biophys. Res. Commun. 379

      Pages: 817-823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] 肥満と糖代謝におけるケモカインCXCL14の新たな役割2008

    • Author(s)
      原孝彦
    • Journal Title

      生化学 80

      Pages: 1133-1136

    • NAID

      10024915541

    • Data Source
      KAKENHI-PROJECT-19659430
  • [Journal Article] Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells.2008

    • Author(s)
      T. Hara, M. Schwieger, R. Kazama, S. Okamoto, K. Minehata, M. Ziegler, J. Lohler, and C. Stocking.
    • Journal Title

      Oncogene 27

      Pages: 3865-3869

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Circulating IGF-binding protein 7 (IGFBP7) levels are elevated in patients with endometriosis or undergoing diabetic hemodialysis2008

    • Author(s)
      M. Kutsukake, R. Ishihara, K. Momose, K. Isaka, O. Itokazu, C. Higuma, T. Matsutani, A. Matsuda, A. Sasajima, T. Hara., K. Tamura
    • Journal Title

      Reprod. Biol. Endocrinol 6

      Pages: 54-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659430
  • [Journal Article] Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells2008

    • Author(s)
      T. Hara, M. Schwieger, R. Kazama, S. Okamoto, K. Minehata, M. Ziegler, J. Lohler, C. Stocking
    • Journal Title

      Oncogene 27

      Pages: 3865-3869

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Acceleration of chronic myeloproliferation by enforced expression of Meisl or Meis3 in Icsbp-deficient bone marrow cells.2008

    • Author(s)
      T. Hara, M. Schwieger, et. al.
    • Journal Title

      Oncogene (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] ヒトES細胞は上胚盤葉由来幹細胞EpiSCsに相当する2007

    • Author(s)
      原 孝彦
    • Journal Title

      実験医学 25

      Pages: 2166-2167

    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Mitochondrial bottleneck occurs without reduction of mtDNA content in mouse female germ cells2007

    • Author(s)
      L.Cao, H.Shitara, (4 authors), T.Hara, J.Hayashi, H.Yonekawa
    • Journal Title

      Nature Genetics 39

      Pages: 386-390

    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Mitochondrial bottleneck occurs without reduction of mtDNA content in mouse female germ cells.2007

    • Author(s)
      L. Cao, H. Shitara, T. Horii, Y. Nagao, H. Imai, K. Abe, T. Hara, J. Hayashi, and H. Yonekawa.
    • Journal Title

      Nat. Genet. 39

      Pages: 386-390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] 制御性T細胞のアナジーはレプチンに依存する2007

    • Author(s)
      原 孝彦
    • Journal Title

      実験医学 25

      Pages: 1208-1209

    • Data Source
      KAKENHI-PROJECT-19659430
  • [Journal Article] Involvement of stathmin in the proliferation and differentiation of immortalized human endometrial stromal cells2007

    • Author(s)
      K.Tamura, M.Yoshie, T.Hara, K.Isaka, H.Kogo
    • Journal Title

      Journal of Reproduction and Development (in press)

    • NAID

      130000053896

    • Data Source
      KAKENHI-PROJECT-17659565
  • [Journal Article] Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development.2006

    • Author(s)
      T. Suzuki, Y. Kanai, T. Hara, J. Sasaki, T. Sasaki, M. Kohara, T. Maehama, C. Taya, H. Shitara, H. Yonekawa, M. A. Frohman, T. Yokozeki, and Y. Kanaho.
    • Journal Title

      Mol. Cell Biol. 26

      Pages: 6149-6156

    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Expression of stathmin family genes in the murine uterus during early pregnancy.2006

    • Author(s)
      M.Yoshie, K.Tamura, T.Hara, H.Kogo.
    • Journal Title

      Molecular Reproduction and Development 73

      Pages: 164-172

    • Data Source
      KAKENHI-PROJECT-17659565
  • [Journal Article] Spermatogonial cell-mediated activation of an IκBζ-independent NF-κB pathway in Sertoli cells induces transcription o the lipocalin-2 gene.2006

    • Author(s)
      R.Fujino, K.Tanaka, M.Morimatsu, K.Tamura, H.Kogo, T.Hara.
    • Journal Title

      Molecular Endocrinology (In press)

    • Data Source
      KAKENHI-PROJECT-17659565
  • [Journal Article] Expression of stathmin in human uterus and decidualizing endometrial stromal cells2006

    • Author(s)
      K.Tamura, M.Yoshie, (3 authors), T.Hara, H.Kogo.
    • Journal Title

      Reproduction 132

      Pages: 625-635

    • Data Source
      KAKENHI-PROJECT-17659565
  • [Journal Article] Spermatogonial cell-mediated activation of an IκBζ-independent NF-κB pathway in Sertoli cells induces transcription of the lipocalin-2 gene2006

    • Author(s)
      R.Fujino, K.Tanaka, (3 authors), T.Hara
    • Journal Title

      Molecular Endocrinology 20

      Pages: 904-915

    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Expression of stathmin family genes in the murine uterus during early pregnancy2006

    • Author(s)
      M.Yoshie, K.Tamura, T.Hara, H.Kogo
    • Journal Title

      Molecular Reproduction and Development 73

      Pages: 164-172

    • Data Source
      KAKENHI-PROJECT-17659565
  • [Journal Article] Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development2006

    • Author(s)
      T.Suzuki, Y.Kanai, T.Hara, (9 authors), Y.Kanaho
    • Journal Title

      Molecular and Cellular Biology 26

      Pages: 6149-6156

    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Spermatogonial cell-mediated activation of an IκBζ-independent NF-кB pathway in Sertoli cells induces transcription of the lipocalin-2 gene.2006

    • Author(s)
      R. Fujino, K. Tanaka, M. Morimatsu, K. Tamura, H. Kogo, and T. Hara.
    • Journal Title

      Mol. Endocrinol. 20

      Pages: 904-915

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells2006

    • Author(s)
      R.Fujino, Y.Ishikawa, (5 authors), T.Hara
    • Journal Title

      Molecular Reproduction and Development 72

      Pages: 955-966

    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells.2006

    • Author(s)
      R. Fujino, Y. Ishikawa, K. Tanaka, M. Kanatsu-Shinohara, K. Tamura, H. Kogo, T. Shinohara and T. Hara.
    • Journal Title

      Mol. Reprod. Dev. 73

      Pages: 955-966

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Journal Article] Capollary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells.2006

    • Author(s)
      R.Fujino, Y.Ishikawa, K.Tanaka, M.Kanatsu-Shinohara, K.Tamura, H.Kogo, T.Shinohara, T.Hara.
    • Journal Title

      Molecular Reproduction and Development (In press)

    • Data Source
      KAKENHI-PROJECT-17659565
  • [Journal Article] 骨格筋の再生医学2005

    • Author(s)
      原 孝彦, 中山由紀, 奈良典子
    • Journal Title

      臨床神経学 45

      Pages: 880-882

    • NAID

      10016918571

    • Data Source
      KAKENHI-PROJECT-17659565
  • [Journal Article] Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells.2005

    • Author(s)
      R.Doyonnas, J.S.Nielsen, S.Chelliah, E.Drew, T.Hara, A.Miyajima, K.M.McNagny.
    • Journal Title

      Blood 105

      Pages: 4170-4178

    • Data Source
      KAKENHI-PROJECT-17659565
  • [Journal Article] Expression and the biological activities of insulin-like growth factor-binding protein related protein 1 in rat uterus during the periimplantation period.2004

    • Author(s)
      K.Tamura, T.Hara et al.
    • Journal Title

      Endocrinology 145

      Pages: 5243-5251

    • Data Source
      KAKENHI-PROJECT-14657412
  • [Journal Article] Expression an dthe biological activities of insulin-like growth factor-binding protein related protein 1 in rat uterus during the periimplant ation period.2004

    • Author(s)
      K.Tamura, T.Hara et al.
    • Journal Title

      Endocrinology 145

      Pages: 5243-5251

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390308
  • [Journal Article] Expression and the biological activities of insulin-like growth factor-binding protein related protein 1 in rat uterus during the periimplantation period.2004

    • Author(s)
      K.Tamura, T.Hara et al.
    • Journal Title

      Endocrinology 145

      Pages: 5243-5251

    • Data Source
      KAKENHI-PROJECT-15039237
  • [Journal Article] Expression and the biological activities of insulin-like growth factor-binding protein related protein 1 in rat uterus during the periimplantation period.2004

    • Author(s)
      K.Tamura, T.Hara et al.
    • Journal Title

      Endocrinol., 145

      Pages: 5243-5251

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390308
  • [Journal Article] Expression and the biological activities of insulin-like growth factor-binding protein related protein 1 in rat uterus during the periimplantation period.2004

    • Author(s)
      K.Tamura, T.Hara et al.
    • Journal Title

      Endocrinology 145

      Pages: 5243-5251

    • Data Source
      KAKENHI-PROJECT-15390308
  • [Journal Article] Enhanced expression of uterine stathmin during the process of implantation and decidualization in rats.2003

    • Author(s)
      K.Tamura, T.Hara et al.
    • Journal Title

      Endocrinol., 144

      Pages: 1464-1473

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390308
  • [Journal Article] Enhanced expression of uterine stathmin during the process of implantation and decidualization in rats.2003

    • Author(s)
      K.Tamura, T.Hara et al.
    • Journal Title

      Endocrinology 144

      Pages: 1464-1473

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390308
  • [Patent] 白血病治療用医薬組成物2018

    • Inventor(s)
      原 孝彦, 宮下和也, 牧 昌次郎, 他4名
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Patent] ケモカインCXCL14を利用した自然免疫活性化アジュバント2017

    • Inventor(s)
      種子島幸祐, 原 孝彦, 重永 章, 大高 章, 高橋伶奈.
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Patent] ケモカインCXCL14を利用した自然免疫活性化アジュバント2016

    • Inventor(s)
      種子島幸祐, 高橋伶奈, 原孝彦, 辻耕平, 重永章, 大高章
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-28
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Patent] CXCR4活性阻害ペプチド及びその用途2011

    • Inventor(s)
      大高 章、原 孝彦、重永 章、種子島幸祐
    • Industrial Property Rights Holder
      大高 章、原 孝彦、重永 章、種子島幸祐
    • Filing Date
      2011
    • Data Source
      KAKENHI-PROJECT-23659481
  • [Patent] CXCR4活性阻害ペプチド及びその用途2011

    • Inventor(s)
      原 孝彦, 大高 章, 重永 章, 種子島幸祐
    • Industrial Property Rights Holder
      原 孝彦, 大高 章, 重永 章, 種子島幸祐
    • Filing Date
      2011-11-17
    • Data Source
      KAKENHI-PROJECT-23659481
  • [Patent] BRAKノックアウト非ヒト動物2006

    • Inventor(s)
      原 孝彦, 奈良典子, 他4名
    • Filing Date
      2006-12-05
    • Data Source
      KAKENHI-PROJECT-17659565
  • [Patent] 筋ジストロフィーで発現低下する筋再生関連プロテアーゼRAMPをコードするマウスおよびヒトcDNAのクローニング2003

    • Inventor(s)
      原 孝彦, 中山由紀
    • Filing Date
      2003-08-29
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390308
  • [Presentation] ケモカインCXCL14とIg superfamily タンパクによるオリゴデオキシヌクレオチドの細胞内送達機構の解析2022

    • Author(s)
      種子島幸祐, 斎藤理佐, 原 孝彦
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K08702
  • [Presentation] Innate immune responses triggered by CpG DNA-CXCL14 complex is mediated by Immunogloblin superfamily proteins.2022

    • Author(s)
      斎藤理佐, 種子島幸祐, 原 孝彦
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K08702
  • [Presentation] Ig superfamily膜タンパク質はCpG DNA/CXCL14複合体に結合する2021

    • Author(s)
      斎藤理佐, 種子島幸祐, 成瀬公人, 重永章, 大髙 章, 原 孝彦
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K08702
  • [Presentation] 乳がん細胞におけるBIG3-PHB2相互作用を標的とした高持続性架橋ペプチドの開発2020

    • Author(s)
      安養寺 啓太央, 粟飯原 圭佑, 吉丸 哲郎, 西川 祐輔, 小松 正人, 重永 章, 片桐 豊雅, 大髙 章
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] CXCケモカインのCpG ODN細胞内送達活性の分子メカニズム2020

    • Author(s)
      種子島幸祐, 岩瀬璃奈, 中川美帆, 斎藤理佐, 成瀬公人, 重永 章, 大髙 章, 原 孝彦
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K08702
  • [Presentation] 安定なα-イミノリン酸エステルの開発とキラルα-アミノリン酸の触媒的不斉合成への応用2020

    • Author(s)
      榊原 拓哉, 猪熊 翼, 増井 香奈, 重永 章, 大髙 章, 山田 健一
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] CpG DNAと CXCL14による自然免疫系の協調的な調節メカニズム2019

    • Author(s)
      種子島 幸祐, 三井 貴洋, 岩瀬 璃奈, 成瀬 公人, 重永 章, 大髙 章, 原 孝彦
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 天然マクロライドの全合成が拓く新規多発性骨髄腫治療薬2019

    • Author(s)
      浜田 麻衣, 森崎 巧也, 中山 淳, 寺町 順平, 辻 大輔, 重永 章, 山本 武範, 篠原 康雄, 大髙 章, 伊藤 孝司, 安部 正博, 難波 康祐
    • Organizer
      創薬懇話会2019 in 秋保
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 安定なα-イミノリン酸エステルへの触媒的不斉付加を用いるキラルα-アミノリン酸の合成2019

    • Author(s)
      榊原 拓哉, 猪熊 翼, 増井 香奈, 重永 章, 大髙 章, 山田 健一
    • Organizer
      第45回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] がん抑制因子PHB2の部分配列を基盤とした乳がん阻害ペプチドの開発2019

    • Author(s)
      安養寺 啓太央, 粟飯原 圭佑, 吉丸 哲郎, 重永 章, 片桐 豊雅, 大髙 章
    • Organizer
      創薬懇話会2019 in 秋保
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] ケモカイン CXCL14の脳内ミクログリアに対する働き2019

    • Author(s)
      中川 美帆, 種子島 幸祐, 三井 貴洋, 成瀬 公人, 重永 章, 大髙 章, 佐久間 啓, 原 孝彦
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 急性赤白血病細胞の増殖を抑制する低分子化合物の創出.2018

    • Author(s)
      吉田千紘, 武智あづさ, 鉢呂佳史,八木拓哉, 原 孝彦, 牧 昌次郎.
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] 転写因子Gata4によるマウスES細胞から原始内胚葉系細胞への分化誘導メカニズム.2018

    • Author(s)
      田畑陽美, 北島健二, 原 孝彦.
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] 寿命死直前のショウジョウバエで発現変動する遺伝子群の同定.2018

    • Author(s)
      武智あづさ, 大沼康平, 種子島幸祐, 相垣敏郎, 西藤泰昌, 原 孝彦.
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] DDX1の欠損はp53経路を介してマウス胚性幹細胞の増殖を抑制する.2018

    • Author(s)
      鈴木輝彦, 原 孝彦.
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] CpG DNA/CXCL14複合体に対する候補受容体の発現クローニング2018

    • Author(s)
      三井 貴洋、種子島 幸祐、成瀬 公人、重永 章、大髙 章、原 孝彦
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Development of anti-cancer peptide based on prohibitin 2.2018

    • Author(s)
      Anyohji, K.; Aihara, K.; Yoshimaru, T.; Shigenaga, A.; Katagiri, T.; Otaka,A.
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] CXCL14とCpG DNAの相互作用によるTLR9活性化の特異性と責任領域の解析2018

    • Author(s)
      岩瀬 璃奈、成瀬 公人、種子島 幸祐、重永 章、大髙 章、原 孝彦
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 急性Tリンパ芽球性白血病細胞の増殖を特異的に抑える低分子化合物の創出.2018

    • Author(s)
      鉢呂佳史, 吉田千紘, 宮下和也, 八木拓哉, 武智あづさ, 原 孝彦, 牧 昌次郎.
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] 急性Tリンパ芽球性白血病細胞の増殖を特異的に抑える化合物の標的分子探索.2018

    • Author(s)
      八木拓哉, 鉢呂佳史, 吉田千紘, 西藤泰昌, 武智あづさ, 宮下和也, 牧 昌次郎, 原 孝彦.
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] CpG DNA/CXCL14複合体に対する候補受容体の発現クローニング.2018

    • Author(s)
      三井貴洋, 種子島幸祐, 成瀬公人, 重永 章, 大髙 章, 原 孝彦.
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] CXCL14とCpG DNAの相互作用によるTLR9活性化の特異性と責任領域の解析.2018

    • Author(s)
      岩瀬璃奈, 成瀬公人, 種子島幸祐, 重永 章, 大髙 章, 原 孝彦.
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] 転写因子Gata2の赤血球巨核球誘導ドメインの同定.2018

    • Author(s)
      北島健二, 原 孝彦.
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] Multiple functions of CXCL14 in the CpG DNA transport into dendritic cells/macrophages for modulating Toll-like receptor 9 signaling.2018

    • Author(s)
      Takahiko Hara.
    • Organizer
      第47回日本免疫学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] チオエステル等価体ユニットを利用した環状ペプチド効率的合成法の開発2017

    • Author(s)
      寺中孝久、粟飯原圭佑、山岡浩輔、猪熊 翼、重永 章、大髙 章
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] ハダカデバネズミ皮膚線維芽細胞株の樹立とゲノム編集.2017

    • Author(s)
      中曽根茉季, 鈴木輝彦, 三浦恭子, 原 孝彦.
    • Organizer
      第40回日本分子生物学会年会ConBio2017
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] Development of long-lasting stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells2017

    • Author(s)
      Akira Otaka, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga and Toyomasa Katagiri
    • Organizer
      The 6th Pharmaceutical Sciences World Congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] マウスES細胞から血液細胞への分化における転写因子Gata2のドメイン特異的な機能.2017

    • Author(s)
      北島健二, 鹿子田 真衣, 原 孝彦.
    • Organizer
      第40回日本分子生物学会年会ConBio2017
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] 新しいゲノム編集技術によるDdx1遺伝子のコンディショナルノックアウト.2017

    • Author(s)
      鈴木 輝彦, 田中貴代子, 原 孝彦.
    • Organizer
      第40回日本分子生物学会年会ConBio2017
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] 急性Tリンパ芽球性白血病T-ALLに対する新しい治療薬の開発研究.2017

    • Author(s)
      原 孝彦
    • Organizer
      老年者造血器疾患研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] DDX1過剰発現とPTPN23欠損による精巣腫瘍発症モデル.2017

    • Author(s)
      池田成海, 田中貴代子, 原 孝彦.
    • Organizer
      第40回日本分子生物学会年会ConBio2017
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] 光応答性アポリポタンパク質の開発2017

    • Author(s)
      川原遥華、 奥平桂一郎、 宮下直樹、 津田雄介、 森本恭平、 辻 耕平、 重永 章、 大髙 章、 石田竜弘
    • Organizer
      日本薬剤学会第32年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] ヒトiPS細胞の血液細胞分化に対するLIMホメオドメイン転写因子Lhx2の機能.2017

    • Author(s)
      高橋佑奈, 北島健二, 原 孝彦.
    • Organizer
      第40回日本分子生物学会年会ConBio2017
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] 急性Tリンパ芽球性白血病を標的としたリード化合物の探索.2016

    • Author(s)
      宮下和也, 加賀谷紀貴, 泉川美穂, 稲本恭子, 名島悠峰, 土岐典子, 小林 武, 垣花和彦,合山 進, 北村俊雄, 大橋一輝, 新家一男, 原 孝彦.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] CXCケモカインCXCL14はCpG DNAに結合し、Toll-like receptor 9シグナルを活性化する.2016

    • Author(s)
      種子島幸祐, 髙橋伶奈, 塗屋秀子, 成瀬公人, 辻耕平, 重永 章, 大髙 章, 原 孝彦.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] Growth Suppressing Activity of Lhx2 in Human T Cell Acute Lymphoblastic Leukemia (T-ALL)-derived Cells and Large-scale Screening of Lead Compounds Targeting T-ALL.2016

    • Author(s)
      K. Miyashita, N. Kagaya, M. Izumikawa, K. Kitajima, K. Watakabe-Inamoto, Y. Najima, N. Doki, T. Kobayashi, K. Kakihana, S. Goyama, T. Kitamura, K. Ohashi, K. Shin-ya, and T. Hara.
    • Organizer
      58th ASH (American Society of Hematology) Annual Meeting and Exposition
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] Intein-inspired Amide Bond Processing Device.2016

    • Author(s)
      Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka
    • Organizer
      34th European Peptide Symposium 2016 & 8th International Peptide Symposium
    • Place of Presentation
      Leipzig (Germany)
    • Year and Date
      2016-09-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究2016

    • Author(s)
      山岡浩輔、粟飯原圭佑、 成瀬公人、 猪熊 翼、 重永 章、 大髙 章
    • Organizer
      創薬懇話会2016 in 蓼科
    • Place of Presentation
      エクシブ蓼科(長野県茅野市)
    • Year and Date
      2016-06-30
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] A Novel Function of a CXC-type Chemokine CXCL14 as a Specific Carrier of CpG DNA into Dendritic Cells for Activating Toll-like Receptor 9-mediated Adaptive Immunity.2016

    • Author(s)
      T. Hara, K. Tanegashima, R. Takahashi, H. Nuriya, N. Naruse, K. Tsuji, A. Shigenaga, and A. Otaka.
    • Organizer
      58th ASH (American Society of Hematology) Annual Meeting and Exposition
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04728
  • [Presentation] In vitro induction of HSC-like cells from mouse ESCs/iPSCs by a transcription factor Lhx22013

    • Author(s)
      *K. Kitajima, M. Kawaguchi, K. Miyashita, and T. Hara
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] CXCL12-CXCR4軸を介した幹細胞誘引の調節因子2013

    • Author(s)
      *原孝彦, 種子島幸祐, 鈴木健司, 辻耕平, 重永章, 長澤丘司, 大高章
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] 転写制御因子 Lhx2 は急性 T リンパ芽球性白血病細胞の増殖を抑制する.2013

    • Author(s)
      宮下和也, 北島健二, 原 孝彦
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Gata2 はhemogenic endothelial cells からの血液細胞出芽を促進する2013

    • Author(s)
      川口真実, 北島健二, 原孝彦
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] ケモカインCXCL14は, CXCL12-CXCR4シグナル経路を阻害する2013

    • Author(s)
      種子島幸祐, 鈴木健司, 辻耕平, 重永章, 大高章, 原孝彦
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Identification of The CXCL14 Receptor: CXCL14 is a Natural Inhibitor of The CXCL12/CXCR4 Axis.2013

    • Author(s)
      K. Tanegashima, K. Suzuki, T. Nagasawa, and T. Hara
    • Organizer
      第11回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Molecular mechanisms of the Lhx2-mediated generation of hematopoietic stem cell-like cells from murine ES/iPS cells2013

    • Author(s)
      K. Kitajima, M. Kawaguchi, K. Miyashita, M. Iacovino, M. Kyba, and *T. Hara
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] CXCL12-CXCR4軸を介した幹細胞誘引の調節因子2013

    • Author(s)
      原 孝彦, 種子島幸祐, 鈴木健司, 辻耕平, 重永章, 長澤丘司, 大高章
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659481
  • [Presentation] Identification of The CXCL14 Receptor : CXCL14 is a Natural Inhibitor of The CXCL12/CXCR4 Axis2013

    • Author(s)
      K. Tanegashima, K. Suzuki, T. Nagasawa, and T. Hara
    • Organizer
      第11回幹細胞シンポジウム
    • Place of Presentation
      本郷
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Lhx2 は筋脱分化因子 Msx1, Msx2 の発現を制御する.2013

    • Author(s)
      小高悠作, 田中貴代子, 北島健二, 松田良一, 原 孝彦
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic stem-like cell differentiation from mouse embryonic stem cells.2013

    • Author(s)
      ○K. Kitajima, M. Kawaguchi, M. Iacovino, M. Kyba, and T. Hara
    • Organizer
      第11回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Gata2 は hemogenic endothelial cells からの血液細胞出芽を促進する.2013

    • Author(s)
      川口真実, 北島健二, 原 孝彦
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic stem-like cell differentiation from mouse embryonic stem cells2013

    • Author(s)
      *K. Kitajima, M. Kawaguchi, M. Iacovino, M. Kyba, and T. Hara
    • Organizer
      第11回幹細胞シンポジウム
    • Place of Presentation
      本郷
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] ケモカインCXCL14は、CXCL12-CXCR4シグナル経路を阻害する.2013

    • Author(s)
      種子島幸祐, 鈴木健司, 辻 耕平, 重永 章, 大高 章, 原 孝彦
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Molecular mechanisms of the Lhx2-mediated generation of HSC-like cells from embryonic stem cells2013

    • Author(s)
      K. Kitajima, M. Kawaguchi, K. Miyashita, M. Iacovino, M. Kyba, and *T. Hara
    • Organizer
      2nd IGAKUKEN International Symposium on Hematopoietic Stem Cell Development
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-02-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Molecular mechanisms of the Lhx2-mediated generation of hematopoietic stem cell-like cells from murine ES/iPS cells.2013

    • Author(s)
      K. Kitajima, M. Kawaguchi, K. Miyashita, M. Iacovino, M. Kyba, ○T. Hara
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] CXCL12-CXCR4軸を介した幹細胞誘引の調節因子.2013

    • Author(s)
      原 孝彦, 種子島幸祐, 鈴木健司, 辻耕平, 重永 章, 長澤丘司, 大高 章
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23659481
  • [Presentation] 転写制御因子Lhx2は急性Tリンパ芽球性白血病細胞の増殖を抑制する2013

    • Author(s)
      宮下和也, 北島健二, 原孝彦
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] CXCL14 acts as a natural inhibitor for CXCL12/CXCR4 signaling2012

    • Author(s)
      *T. Hara, K. Tanegashima, K. Tsuji, K. Suzuki, Y. Nakayama, A. Shigenaga, T. Nagasawa, M. Mori, and A. Otaka
    • Organizer
      Gordon Research Conference "Chemotactic Cytokines"
    • Place of Presentation
      Ciocco, Italy
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] ケモカインCXCL14 とその受容体を介した 脂肪蓄積制御2012

    • Author(s)
      種子島幸祐, 鈴木健司,原 孝彦
    • Organizer
      第33回 日本肥満学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23659481
  • [Presentation] CXCL14 acts as a natural inhibitor for CXCL12/CXCR4 signaling. Gordon Research Conference2012

    • Author(s)
      T. Hara, K. Tanegashima, K. Tsuji, K. Suzuki, Y.Nakayama, A. Shigenaga, T. Nagasawa, M. Mori, and A. Otaka
    • Organizer
      Chemotactic Cytokines
    • Place of Presentation
      Il Ciocco, Italy
    • Data Source
      KAKENHI-PROJECT-23659481
  • [Presentation] CXCL14 acts as a natural inhibitor for CXCL12/CXCR4 signaling.2012

    • Author(s)
      T. Hara, K. Tanegashima, K. Tsuji, K. Suzuki, Y. Nakayama, A. Shigenaga, T. Nagasawa, M. Mori, and A. Otaka
    • Organizer
      Gordon Research Conference “Chemotactic Cytokines”
    • Place of Presentation
      Il Ciocco, Italy
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659481
  • [Presentation] Underlying mechanisms of the in vitro induction of hematopoietic stem cell-like cells from mouse embryonic stem cells by Lim-homeobox transcription factor, Lhx22012

    • Author(s)
      K. Kitajima, M. Kyba, and T. Hara
    • Organizer
      10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Identification of G protein coupled receptors which constitute the functional CXCL14 receptors2012

    • Author(s)
      鈴木健司, 種子島幸祐, 中山由紀, 重永章, 長澤丘司, 大高章, 森正明, 原孝彦
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] 転写因子Lhx2によるマウス多能性幹細胞から造血幹細胞への分化誘導2012

    • Author(s)
      北島健二, 川口真実, 籾山和沙, Michael Kyba, 原 孝彦
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] 転写因子Lhx2の強制発現はマウスES細胞からの原始造血前駆細胞分化を促進する2012

    • Author(s)
      川口真実, 北島健二, M. Kyba, 原孝彦
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] ケモカインCXCL14とその受容体を介した脂肪蓄積制御2012

    • Author(s)
      種子島幸祐, 鈴木健司,原 孝彦
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23659481
  • [Presentation] Induction of hematopoietic stem-like cells from mouse pluripotent stem cells by LIM-homeobox transcription factor Lhx22012

    • Author(s)
      *北島健二, 川口真実, 籾山和沙, M. Kyba, 原孝彦
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Underlying mechanisms of the in vitro induction of hematopoietic stem cell-like cells from mouse embryonic stem cells by Lim-homeobox transcription factor, Lhx2.2012

    • Author(s)
      K. Kitajima, M. Kyba, and T. Hara
    • Organizer
      10th Annual Meeting of International Society for Stem Cell Research
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Effects of ectopic expression of LIM-homeobox transcription factor lhx2 on in vitro differentiation of ESCs/iPSCs2011

    • Author(s)
      北島健二, 原孝彦
    • Organizer
      第44回日本発生生物学会年会
    • Place of Presentation
      宜野湾
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] Identification of G protein coupled receptors which constitute the functional CXCL14 receptors.2011

    • Author(s)
      鈴木健司, 種子島幸祐, 中山由紀, 重永 章, 大高 章, 長澤丘司, 森 正明, 原 孝彦
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23659481
  • [Presentation] In vivo analyses of mouse iPSC-derived HSC-like cells generated by enforced expression of LIM-homeobox transcription factor Lhx22011

    • Author(s)
      K.Kitajima, T.Hara
    • Organizer
      第9回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] FoxO1 is required for hemangioblast development in mice2011

    • Author(s)
      K.Minehata, K.Kitajima, M.Kyba, T.Hara
    • Organizer
      第9回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] In vivo analyses of mouse iPSC-derived HSC-like cells generated by enforced expression of LIM-homeobox transcription factor Lhx22011

    • Author(s)
      K. Kitajima and T. Hara
    • Organizer
      第9回幹細胞シンポジウム
    • Place of Presentation
      六本木
    • Data Source
      KAKENHI-PROJECT-23390256
  • [Presentation] CXCL14 is required for body weight gain in female mice2009

    • Author(s)
      T. Hara, Y. Nakayama, K. Tanegashima
    • Organizer
      Keystone Symposia“Obesity : Novel Aspects of the regulation of Body Weight
    • Place of Presentation
      Banff, Canada
    • Data Source
      KAKENHI-PROJECT-19659430
  • [Presentation] DDX1遺伝子の過剰発現が精巣腫瘍形成を促進する2008

    • Author(s)
      田中貴代子, 原孝彦
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Presentation] CMG-1は精母細胞のCyclin-D2および接着関連遺伝子の転写を制御する2008

    • Author(s)
      大林謙一郎, 田中貴代子, 藤野隆介, 田村和広, 原孝彦
    • Organizer
      第6回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Presentation] 精巣腫瘍形成におけるDDX1の役割2008

    • Author(s)
      田中貴代子, 原孝彦
    • Organizer
      第6回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Presentation] Ddx1遺伝子の精巣形成過程における発現と機能解析2007

    • Author(s)
      大林謙一郎、田中貴代子、藤野隆介、田村和広、向後博司、原孝彦
    • Organizer
      第30回日本分子生物学会年会BMB2007
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Presentation] Pre-leukemic amplification of granulocytes by enforced expression of Meis1 or Meis3 in hematopoietic stem cells of ICSBP-deficient mice.2007

    • Author(s)
      T. Hara, M. Schwieger, R. Kazama, S. Okamoto, and C. Stocking.
    • Organizer
      5th Annual Meeting of International Society for Stem Cell Research (ISSCR)
    • Place of Presentation
      Cairns, Australia
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Presentation] Ddx1遺伝子の精巣形成過程における発現と機能解析2007

    • Author(s)
      田中 貴代子、中山 由紀、原 孝彦
    • Organizer
      第30回日本分子生物学会年会-BMB2007
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Presentation] Meis1/3遺伝子はICSBP欠損マウスの顆粒球分化を促進する2007

    • Author(s)
      原孝彦、Maike Schwieger、風間律子、岡本士毅、Carol Stocking
    • Organizer
      第5回幹細胞シンポジウム
    • Place of Presentation
      淡路島
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Presentation] A spermatogonial stem cell-derived factor induces the transcription of lipocalin-2/24p3 gene in Sertoli cells by an IкBκζ-independent NF-κB pathway.2006

    • Author(s)
      T. Hara, R. Fujino, K. Tanaka, M. Morimatsu, K. Tamura, and H. Kogo.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Presentation] Physiological function of the small G protein ARF6 in hepatic cord formation and liver development.2006

    • Author(s)
      T. Suzuki, Y. Kanai,Y, T. Hara, J. Sasaki, T. Sasaki, M. Kohara, T. Maehama, T. Yokozeki, and Y. Kanaho.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-18
    • Data Source
      KAKENHI-PROJECT-18390441
  • [Presentation] ハダカデバネズミ線維芽細胞における26Sプロテアソーム活性の亢進

    • Author(s)
      杉本貴彦, 鈴木輝彦, 三浦恭子, 蔭山俊, 吉原英人, 海保愛, 佐伯泰, 田中啓二, 原 孝彦
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-25670153
  • [Presentation] Identification of G protein coupled receptors which constitute the functional CXCL14 receptors.

    • Author(s)
      鈴木健司、種子島幸祐、中山由紀、重長 章、大高 章、長澤丘司、森 正明、原 孝彦
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23659481
  • 1.  MIYAJIMA Atsushi (50135232)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  NAKAYAMA Yuki (30332381)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 3.  KINOSHITA Taisei (40301113)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  若尾 宏 (10280950)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  TANAKA Kiyoko (40124474)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KITAJIMA Kenji (10346132)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 35 results
  • 7.  KIYONO Mari (60376621)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SUZUKI Teruhiko (70621027)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  KOGO Hiroshi (10057341)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TAMURA Kazuhiro (70281409)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  OKAMOTO Shiki (40342919)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  OTAKA Akira (20201973)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 20 results
  • 13.  岩槻 健 (50332375)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  伊藤 孝司 (00184656)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  真板 宣夫 (00404046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  広川 貴次 (20357867)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  COPELAND Neal
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  JENKINS Nancy
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  DAAR Ira
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  DONOVAN Peter
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  Takahashi yuna
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 22.  NEAL Copelan
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  NANCY Jenkin
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  IRA Daar
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  PETER Donova
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  TANEGASHIMA Kosuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 27.  SHIGENAGA Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 28.  INOKUMA Tsubasa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  YOSHIMARU Tetsuro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  押村 光雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  三好 康雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  片桐 豊雅
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  森本 裕子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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